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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <name>A0AAE0J0F9_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
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        <location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3334648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J6G8_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Magnesium transporter NIPA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_304854</name>
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    <organism evidence="7 8">
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Mg_trans_NIPA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3337822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="801" mass="86806" checksum="D755FF29F07AF278" modified="2024-05-29" version="1">MDQAVQILEVAHHVYARADSTADLDHATRPPSYKIIGILLAVGSGFFIGSSFVVKKMGLLKANEKYNEAAGEGYGYLKNAWWWAGMTLMLIGEVLNFAAYMFVDAILVTPLGALSVVIATVGSAIVLKERLSMIGKVSCFLCIVGSVVIVLNAPQESAVANIQQFQEFVITPSFLSYAGVIVLGAAIAAWYAGPRWGNKNMLVYISICSWIGGLSVVSTQGLGSAIVAQAGGEPQFKGWFIYVVIVFFIASLLTELIYLNKALNLFNAAMVTPTYYVYFTSTTIITSAVLFKGFKGTAVSIVTVVFGFLTICSGVVLLQLSKSAKDVPDAAVLSGDLDQFRTVAEQEQPETEPKADALRGAAAIVRRLSSAKQQKMEMEELKRLHQEKMMETLETVGEDGPVYEWDGLRRRRTTLGSNSGSRRSRAATSATFQLPPPTIHPPLGWSHFPTDEELAAADRPASPALSSIVGTIRNRARSVLLPGHPNFRPNSASNKVQSPMHPVQLTEIAVPAQNFDEETGYYPQGSAAGPSKGYLYDRPGSRGSISSSGRRVQFSTEANHPSSSTLAPPLAPPPPRTPPGATRQFSFQSVFKRGDRHSQHAHTQSDGANSQLSSHSSDKQDRDRLTTHRGFSTPHIIRGASEEETLGLVRGDSRDSRTTPHTSKQYDDDDDDECSEEFEDVGRYIDEKQSRYGPSITHSPTRAPGVTGGGQRGEQQYPGGEEEDVKKEYTEHVESGGQGQGQGQGQGQQQRSARDDPSSYRERLRRLREHERGQNSGSGSGPSPPSKSNSSRGDGGGFHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J753</accession>
    <name>A0AAE0J753_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Autophagy-related protein 33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_313391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677603.1">
        <property type="nucleotide sequence ID" value="XM_062823329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J753"/>
    <dbReference type="GeneID" id="87860483"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3338152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23347" checksum="B466D1DAC8526A35" modified="2024-05-29" version="1">MTTRGVSVLKFVGTVSLGLLTGVSFTLSTLTIPALLTLPSANDAARALESLSTSAKKHLRTLSTVSGSAFALAYYLSPRAYRHPYLIYTSLLVFGSRFITSGFFGPYFSFITPAVPASFSSGMSSVSFVTARSSQQKKKTSTPRGLEASYEVLGDPSHSESGSEDVEEELANVNGEEVRANVEVFLKKNIVQSAVAGVAFLMSVVGIWGDGLGQRTIVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J767</accession>
    <name>A0AAE0J767_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_446084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677639.1">
        <property type="nucleotide sequence ID" value="XM_062825785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J767"/>
    <dbReference type="GeneID" id="87862939"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="237" mass="25933" checksum="7E07F3A937213EA0" modified="2024-05-29" version="1">MDEWMLAVSRFGPQVLLPQSLNATLTAHTSVVRCVKVKRHTPYAFGWRGVLVLVLVLGDNADTVECGCPVVFLCTFADPCLKNRANNQTSIELYVCTLTYSTHVVVAMGFMFHCMFQCQVQRLHAGESSGWAADICESQLQCSTALTELWQLCPDTYPLTSSSGAPESGSRELKVYGSIESNEFEDGNVEGGVESNDIESSNIKSIGVESSNVEDSIESDDIEDNDIEDNDIKDGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7M8</accession>
    <name>A0AAE0J7M8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_582265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677820.1">
        <property type="nucleotide sequence ID" value="XM_062830848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7M8"/>
    <dbReference type="GeneID" id="87868002"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000077">
        <property type="entry name" value="Probable chitin synthase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="762"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3338369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="884" mass="99647" checksum="6F7758F9AE0B3F43" modified="2024-05-29" version="1">MTINYLGEDEWPVEEIVYTAIVGLVMLAACLEWFLWIAAFMYCLWKVFVKAEHWTVRVLSVIIGIAFMLLRCIFLPIMIVTLPLPSQVVKVWPTAMVSFLQWFAFYSFAGLLTIPWLFCVYQIVTHQLGRTKRIKQVLDEVSAPKVVIVMPCYKEDPEVLVTAIDSVVDCDYPPSCIHVFLSFDGDQEDELYLNTIEKLGVPLTLESYPKSIDVAYKNARITVSRFPHGGKRHCQKMTFKLIDRVYREYLKRNDNLFILFIDSDCILDKVCLQNFVYDMELSPGNRRDMLAMTGVITSTTQKHSLITLLQDMEYIHGQLFERTVESGCGAVTCLPGALTMLRFSAFRRMAKYYFADKAENCEDLFDYAKSHLGEDRWLTHLFMIGAKKRHQIQMCTSAFCKTEAVQTMGSLIKQRRRWFLGFITNEVCMLTDWRLWKRYPILILVRFMQNTIRTTALLFFIMVLALITTTKKIDDLPVGFIAISLGLNWLMMIYFGAKLRRFKIWLYPMMFVLNPFFNWYYMIYGIFTAGQRTWGGPRADAAAADSTTTAQEAIEIAEKTGDDLNIVPESFIPAAQERKGIFAGSAEDKGFTTGTSTGGLGRSKSILQPPDKLVGKFAAPERSANGLYQHFDDSMASVSLFAHAGGSSLMLPTVAGSATTSKRHHQQYQHQYQHQHQLQYRDSFDSTFSAHTTGGNSMSVYMPRRVESIMGEEDRRKYELAQASSGHLVGNPTRVLGQQQQPPPGQVYEFSESELRRAGFYTDSAPEYGRPALPSPSPPHRRLASSDSFDSVGRPAASPTPYQDYGYGQEGYGQRQQGGGSLSVPMPPTPSGTGHQQQRTGRSPLGRASWVRTSTMDQVESEIEASHGGTGGFSDAPGHGRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7Y4</accession>
    <name>A0AAE0J7Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase catalytic core-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_280801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678053.1">
        <property type="nucleotide sequence ID" value="XM_062822873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7Y4"/>
    <dbReference type="GeneID" id="87860027"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000207">
        <property type="entry name" value="Glycoside hydrolase family 128 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042064982" evidence="1">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="326" mass="35697" checksum="73AAA136C0C3E3CD" modified="2024-05-29" version="1">MLTRAIAVAAALLVTSASANSKRGLVFTPNSTFPHDAYIWTAPPTDLTWYYNYKPLPSQIYSNLSQSDFEFVPMLWGAPSDINDKSFYNTIKTLIDERGVNITHILTFNEPDGPGEYGGSDIDPEVAAQVWVNNIVPLQEDYKALRVGLPACTGAPAGLEWSKKFLEACSGLISEDAKTKNCTFDFVPIHWYGNFEGLASHMGEYSAAFPNKSMWVTEYNLANANLQETQAFYKTSAEYLDRLDFVERYSLFGAFRADVSNVGPNAAMLNRDGELTDIGAWYLGRQATGIDPNSGKGGKDSGAVRVPTPGLLTLLLVSLLGLVNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7Z8</accession>
    <name>A0AAE0J7Z8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_315321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677666.1">
        <property type="nucleotide sequence ID" value="XM_062823360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7Z8"/>
    <dbReference type="GeneID" id="87860514"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="252"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3338215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="640" mass="70246" checksum="97F73F991C7B01B7" modified="2024-05-29" version="1">MAVGLINGRLAADEEARAEVDVLNSRLEKTSQLTKKIQASLGRLDATGKSVRDVAGPLSGETRKLQVLGNNIDAVIAAIEKLRSPADNKDDEEQIMRMGPEKAGLSNYLASVKRLNKALNDMKASNLRSTQQTVADLQRLVKTGNSQLESSFDKLLRSETPRAIEPLHYLTKNMPFPVLSQEKITKLGLMNSYLAGVHKQNTGAGSSQESPVIKIYAEVRSQYLLSTLGNLATASTNTAKKKTPEAVYRAGTNGMGTYAQAMEGLFLAEYDNICSIFMREDWGPVFQATCQPALVELGRTLRELSSHIKSHITTDCFLAYEIVEIISGLSNNLESRTGELKSSLAAALKPIRETAKSSLVDLLEETKRQVNGLQSLPADGAPTQLASQTMQRLQSMVDFLRPISSIMISIGDGGWKSAAASKGGATDTIPSLASFDVGADGQEIFAHYCADTIETLLSSLDARARVLLQQKKAVIGVFLANNVTIIERMINESGLATLLQSRLQVLDVWRKKATALYTETCKEISIHLFDTVHTSRTARPGSGQGMVSSASIMKGLSSKDKEKIKGMFTAFNSGFEEMVARHKQFAMEKEVRQMLAQDVQHMLEPLYNRFWDRYHEIDKGKGKYVKYDKGSIAAVFRSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8C5</accession>
    <name>A0AAE0J8C5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_552879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677866.1">
        <property type="nucleotide sequence ID" value="XM_062829925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8C5"/>
    <dbReference type="GeneID" id="87867079"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="391"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3338415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="608" mass="66086" checksum="92D5ED15D2D6056A" modified="2024-05-29" version="1">MASPGRPQRHLDATTGREVVYCYGCENEWYRDDYPHLDLECPRCHNDFVQIVEPDNDPRPGVQQQGPRSDSDPDEDDIEEFLERGPGSFFMRRSVYHSPESPFQSPFNRPSGNGVEDLDSSPDRPRARPDDSGEAVLSRFADMFAELGGARPGQQGGNAFGTQPRIQRTTFTRSGDGMASFTFTTTTTTGGAAGDGPEVPAFDTYVRSRHGNPGIRRHTIIVVTNGRANSNGDGSLFRGLFGNIPSPGAEDPGGGPGQGGGPRGPPLGFAAGLQEFIATLLNPQAAVHGDAVYTQEALDRIITTLMEANPQSNAAPPATQSAIEKLPKKILDEQMVGPEGKAECTICIDEMYKGEEATVLPCKHWFHGECVTLWLKEHNTCPICRMPIEGNNQTGSNSNRNNNSQPSASRQEASTSSSSAFASSTAPGRNPFESLNPFGPQGQLATERLRRSEQEREERLERIRNVAGVRRTDSQSEGISRRTSHSPPSRENSSFNMRSRVRDPSPPRDRGTSTAWQNSSSNSQSNISSRYSGGLGNLWGRTNSNSGQGSSRDRDGQREGGGQQQQNQQQQQQSSSSGNGALGWLRDHFGRGSSGSGSGSDRDRERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8E8</accession>
    <name>A0AAE0J8E8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_285055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678293.1">
        <property type="nucleotide sequence ID" value="XM_062822930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8E8"/>
    <dbReference type="GeneID" id="87860084"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF100">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041972246" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3338933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="654" mass="70580" checksum="318AC2B298CC26B3" modified="2024-05-29" version="1">MILRRLLGLALAAAPLASAVELTGYEYIVVGSGAGGGPLAARLAMAGHKTLLIEAGDDQGNNVNVTVPAYNARSTEDEKMSWDFYVRHYPDDDRQARDWKTSYRLPDGSIYTGLSPPEGAEMLGTLYPRAGVLGGCTAHNALIAVYPHQSDFQYLADLTGDQGWSPENMRKHFVSMEDKNYVNGLYSGHGRDGWLSTEVTPLTIPLKDPQLLSLTLGGAFALGNITQSPINLATVLAADLNADTLARDKTPAYYEVPISSRNGARSGSRDFVVAVRDARNPDGSKKYPLDVRLNCHVTKITFNTTSGSEPVATGVEFLDGAHLYRASPLSPNRASQIRPNGTPGSAKASREVIISGGTYNSPQILKLSGIGPRVELSRFGIPVLVDLPGVGGNLQDHYEIGVNVKVPNNWAALKGCTFQLYGNTSDPCLDRWLNPNVLGDRGTYASSGLAVAMLYKSSVTTDDSYDVFTFGGPVNFAGYYPGYSVDITAEHDWWTWAVLKAHPRNRAGSVTLRSSDPLDTPSIVYNYFDFGSGDYQADLTAMREAIGLARDALKRQAVRTQEVRPGADKQSDGEIEQYIKDGAWGHHASSTCPIGPDGDPMAVLDSKFRVRGVKGLRVVDASVYPRIPGTFTAVSTYLAAEKAAFDILEGLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8J0</accession>
    <name>A0AAE0J8J0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_399456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678255.1">
        <property type="nucleotide sequence ID" value="XM_062823778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8J0"/>
    <dbReference type="GeneID" id="87860932"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="52" mass="5922" checksum="B29C6A368A0E71A9" modified="2024-05-29" version="1" fragment="single">LINIHQGDEFCLVCDPCRTEGRYFIKADIRGNGNNMQLVLEIALVANPYRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J901</accession>
    <name>A0AAE0J901_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_582459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677887.1">
        <property type="nucleotide sequence ID" value="XM_062830850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J901"/>
    <dbReference type="GeneID" id="87868004"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="124" mass="13621" checksum="3D89B16004DBC323" modified="2024-05-29" version="1">MDLTSPVSHPAPHIQYPRVDSSSLPSDRRPPPMTNTEGEDTVPDQEPAWPGVGPRKWCKDYTWIDETSDRSPLLKDCLQIVKNHAAGKNHGGTGSSWPVNTESSRERAFTRSGCRLGGNVARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9T4</accession>
    <name>A0AAE0J9T4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="7" type="ORF">B0H65DRAFT_247002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9T4"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="614"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="813"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="832"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="873" mass="98568" checksum="60BFF4145BD85B91" modified="2024-05-29" version="1">MSRFFRGGDDSSTDSSSEEEEVYTSEEEEEKVQAEDESSSEEESDEEESDEESSSDEEEGAKKKGASRFLQSDDEESEEEEDEQSDDEATTKVKSAKDKRFDELESTISQIQNGQKINDWSLIATEFDKLNRQVVKLQDGSKAPKSYIKAIADLEDYMNETLAKQKVTPKKMNATNARGLNAVKQRIRKNNKDYQTQIDAYRKDSDAFMESDDEVAAPKVVSKVRFEAPVVSAEQQEEDDKGFSTVDSRGKVVQYTPESILKHLRAIIESRGKKNTDRLEQIKVMETLNKVVPITPYQKIRVLQTLISARFDLGAGGAAQMPLDQWKAAERDLASLLEILEKEKDHVVVEGAEEWDDDDHLPTIPEGEKYLKVPGSVVSLIERLDDELTRSLQAIDPHTSEYIDRLTDEGSLYNIIFRGLLYYEHLRKDASLEVPQESLNRIIQRRLDHVYYKPAQVVKILEENAWKQVSAEADSEITPRSQSGDAGKLINILSNYLFENSEGIIRARAMLCQIYFLALHDEYYKSRDLMLTSHLQETIANFDIATQILYNRTLVQVGLCAFRKGLVYDAQNTLQEICGSGRQKELLAQGVMIQRYSQVTPEQERLEKQRQLPFHMHINLELLECVYLTCSMLLEIPLLAQTGSSPDVKKRIISKTYRRMLEYHERQIFTGPPENTRDHVMQASKALAAGEWKKATDFIHSIKIWDLMPNTEDIKTMLAKQIQEEGLRTYLFTYAPFYDTLAIATLSSMFELDSRKVSAVVSKMISHEELAAALDQVTETVIFRKGVELSRLQSLALTLSDKASSLIETNERTLEQKTQGSANAFSRKDNRGGGQRGGGQRGGRGGARTGGNPQRQAGGTQFTGGALGNAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA01</accession>
    <name>A0AAE0JA01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="5" type="ORF">B0H65DRAFT_577577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA01"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="477" mass="51997" checksum="0C2698B7C7995193" modified="2024-05-29" version="1">MMASTSPPPTTSPAMSSTTTTATTKPCVKCRSNPGTLDSRGQLVCRLCFQKFISAKCIKQIGLLNKDVRSSSSSALSDYHSTQKNAGPPQASSRRYLLGLSLGPSSAALLELLNENVEFQVGRGRNAPFELGVVHVSGAGLEGDGKGREREKVEEVVRRLGRRYPRFEFRVVYLEEVVGLETVDWEGLGLGLGLGGFVTEQKDETEVTTTTKAERLRQLFDNLPSSTTSRTDLLRLFTRHLLIAEARKSQCHALLLGSSTTALAELTLSETAKGRGFSLPWQINDGVLGVPSFSPNSSSSLKTDETGILIYHPLRDALRKELVTFTKLSGEPTPIADLLPETDLTTTAAVVSHKDLSIEEVMVRYFADVEENYPSIVANVARTTGKLMRLFGGGGAGADGDEGVRSKTEGEDENEEEDDDDEERLCGLCSMPLDEFGDQRWKGELGEDNYRDVVVGGEGEKKTKQRICYGCERSIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA57</accession>
    <name>A0AAE0JA57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA binding protein Jsn1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_577840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679212.1">
        <property type="nucleotide sequence ID" value="XM_062830710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA57"/>
    <dbReference type="GeneID" id="87867864"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000167">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000339">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="448"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="594"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="658"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="694"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="731"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="946"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="948"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1219" mass="131799" checksum="6471CD2963572972" modified="2024-05-29" version="1">MSNQRPGDHMSLGFPPQSVSLQTRTGSPTSTSPNDPTSAGAIRSPFGLSSGLGQSSKMAGASRSGNGSPSHDMASSGRLFSKRAREIQAQEGISGLPVNPWGGPPTSGNSTPLRENIPESPTDGFPDFTQLPTPDSLPQTRRARAGTVPSRFPAGAGVNGMLNIPALASKTSRPSPSHTPFKSPSPGIEQAEGSASTLLSRLRAGSMPQRSPFAQVPGTSSPFGVSIFSSWTPTGRERGNTLASIASVPSNNPSSPTQSHFSREGAGENDVHMRTLDYLGLAETPQPPRAQLATPYMPTYVDFTKAANRFRSYSVNNKDKYADEEDDYDEDPLTIMENQYAQLQDQLAATNAAIQQHNLAVQAFQAARPRARTAGVLDTPASRILRNYIPTPSRLDASITAADIQLPEERQYEDLPQAVAAMTLGRSNSRNNNGLLSAEEPNMEGPTSALWLGSIPTSTTTSTLTEMFKSYGPILSARVLTHKNCGFVNFERVDSAINAKANMNGKEIFPGAGPIRINFAKPPSASNTPGHDGAFPSPSPDPFAKGQENGQNGSTGASGDASPTPLAGNAIPTVAPLSEMTVDILNIVQQFGATEEDKYKISANLQNAIQFDNFIDEIPPIKEPAHTRVHDAPKLRDIRKRIDNQTLSQQEIENIAIEMLPEIAELASDYLGNTVVQKLFEHCSDSVRDQMLAEIAPHMAEIGVHKNGTWAAQKIIDVCKTPQQLNLIVENLRPYTIPLFLDQYGNYVLQGCLKFGPPYNDFIFETMLSKMWEVSQGRYGARAMRACLESHHATKDQQRMLAAAIALHSVQLATNANGALLLTWFLDTCTFPQRRTVLSPQLVPYLLHLCTHKVAYLTVLKVINQKAEADARDTILKALFFTQNDQVLEAILSDHACGATLIFKVLTTPFFDETIRTQVVENVKNVLIRIKAQPGQGYKRLMDEVGLSTRSGGSNSNNGNNTREHTNNNSNNTNNSERQRPTSRQTPQHQQQNQQQQQQPQPAQQAQQQQPGQFTPGPGQYYNPLNVGAPNYNDMAFGIPRSEGLEIPQQFPAFVPQGQMYGGAATPMAPATALQQMQYQQSMMARGAPPMNNYYPAGMPAGFGGFQTPSPSIDQYRGTQAAMSNGSPIQPPPGAPQMPNMPPGGPQGPYGAAPGFGMNMGMPTPGYGYGAGPAPMGGAGMPPQQQNVGYMQEQGNNNNTSRRGRVSQEFYLCSRMMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB13</accession>
    <name>A0AAE0JB13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_497914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679318.1">
        <property type="nucleotide sequence ID" value="XM_062827804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB13"/>
    <dbReference type="GeneID" id="87864958"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="145"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="257"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="531"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="824" mass="90631" checksum="46C7DD5735EBA380" modified="2024-05-29" version="1">MAPDPNPDHAEHKKKVNLMYASGAEHKAEDDTATAILKKKKKPNQLMVTDAVNDDNSIIALSNNTMEQLQLFRGDTVLVRGKKRKDTVLIVLADDDLDDGSARLNRVVRHNLRVKHGDIITIHPCPDIKYAKRIAVLPIADTVEGITGSLFDVFLAPYFREAYRPVRQGDLFIVRGGMRQVEFKVVEVDPPEYGIVAQDTVIHCEGEPIQRDEEENNLNEVGYDDIGGCRKQMAQIREMVELPLRHPQLFKSIGIKPPRGVLLYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKRDKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILQIHTKNMKLGDDVDLEQIAAETHGYVGSDIAALCSEAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTQENFRFALGVSNPSALREVAVVEVPNVRWEDIGGLETVKQELRESVQYPVDHPEKFLKFGLSPSRGVLFYGPPGTGKTMLAKAVANECAANFISVKGPELLSMWFGESESNIRDIFDKARAAAPCVVFLDELDSIAKARGGSVGDAGGASDRVVNQLLTEMDGMTSKKNVFVIGATNRPEQLDPALCRPGRLDSLIYVPLPDEEGRLGILKAQLRKTPVAADVDLKYIASKTHGFSGADLGFITQRAVKIAIKESITADIQRTKEREAAGEDVEMEDEVEDPVPELTKRHFEEAMSMARRSVSDVEIRRYEAFSQQMKNAGPGAFFKFPEGGVESSGNGGAGNSFGDAGNDDDLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCM2</accession>
    <name>A0AAE0JCM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_467984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680141.1">
        <property type="nucleotide sequence ID" value="XM_062826937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCM2"/>
    <dbReference type="GeneID" id="87864091"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="72139" checksum="C1DD36E51E0217AD" modified="2024-05-29" version="1">MYWLSSTRPRLYHYMIPINHYFMRTKRTVWGVLTLSVATSAFFYFRFTTTTIDLRKYNNIFSWGQAQAHAQLEAGKMACHSAASDEVPQTRDALSREPHFCFYVGTPDLLERRSNEKASHIMTFKEQQQQNSSSSSSSSKVLVLLDGFDKTRTFSPDVNDTLGVQFHWRDPTSDLPFVSPPRIYFVFDLCESSRQRFLPSLMSLLGLALGPQTVPSQLDYDDFDNFLATLNAIDADPTGKGDLAASFASLASELPPHLSPLHPGADSAVIREFLLVLADRTVWSLDMGGQVNSSATKQFFELVKMLASSGGPPPPPPPPETNSNNSTEPDKPSSYMTWYRDWMPKSWGSERPPPHDVEAALIRSRWRSPRHFGPRLLGTGHEMPPLKTMLDAFKEAGYLDTPEGKVETLLSLVQGQGRVTSQPRESRPREVGLVVEAIRYALALSSLSSGSSESGSGSGSGFVADNSTTTTTPTTTPPPPSLRDALTKLDRLKLLPAAARQKGNKELLAWLLDDADKQGGLGGGNLREALNTANYIKGPSPTDRRKTVWLRKGYVLHLAVREGDVDMVKLLLERGAKMLRDDEGRTPLVIARDVLGMNRPGRKEKVEVLEAWLRERGLDSEYWDEPEEYALDASKGEGAFEIPNLKGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCM8</accession>
    <name>A0AAE0JCM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Alkali metal cation/H+ antiporter Nha1 C terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_273914</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679807.1">
        <property type="nucleotide sequence ID" value="XM_062822781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCM8"/>
    <dbReference type="GeneID" id="87859935"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="26"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="460"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="749"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="883"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="961"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3340865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1014" mass="112425" checksum="991647343C974956" modified="2024-05-29" version="1">MAWDKLSITRPHLVYIILGGFTSLFMLCSSIIKERMYIGEATVATLCGLIFGPHAAGLIDPIEWGNIDIVTIEFSRLVLVVQCFAVGVELPKFYMEKHWRSVTFLLIPVMLWGWLITGLFVWWLIPPLNWLESLVVAACVTATDPVLASSVVGKGKFAKRVPKHLRDLLSAESGCNDGMAFPFIYLSLYLILDHREAREVSFHWIVFTILYECVFGAIYGFMVGYIARHGIKYAERHELIDRESFLVFYFVLALFCAGSGSILGVDDLLVGFAAGVGFSNDGWFTNKTEESHVSNVIDLLINLAYFVYLGTIIPWEQFNNFEIGLGAWRLVVLAIMVILFRRIPIMMALKPLIPDIKTWREALFAGHFGPIGVGAIFVAILARAELEHEDPVPLADISSINPNNPHFHLIRLVWPIVTFLVVSSIIVHGSSVAVFTLGKHINTLTITMSYTQANEDGPSWMNRLPRITSVSRSQARNMSDTEDDMKMPEFPPGTLPPTGLPGTFLRRQKEEDKDTGRRERSSSANGRRRRKRWDDGIGPGGPISQSAIFPQRRSQSEQAIASPHDEMSPEPSDTTRLSPSDALTTCRSARKSEKERSSDETASPYEPSPTSGQRDQELEYYDEGDHVIVEDREGNVLAVEPPATGEGENPVEALKEKLEAEAGPSGWSYDALKKKIQNWREEEMAKRKEKEKSTRRSEPARAYQFGTTIIVENEDGEVLKKYELPSGKPENDFVSQGLKYMGIKAGDKSAVAGSAAGGEGSASRPAKPTKRPTWASAVVGGGDASKKKNAVEEQEEDDRHIRFTIGGVGQRMNKEDFIREMQKLDKSTRKEVVDQSNASSAVKNLAKADLTPKQPQQPQQQQPQQPQPAQRRGSPAGSVKSSHSKDSLRSTRQGRPEKLEVMSGGSNPERSESPSRSRSRSPSLLTAEGASAAPSRDVPETAAERRRRLAVLQSVGDDGEGEHGETPAERRRREAALGMSSGAAEDEDSEDDDTPRIPPPRRGIRFAEPTRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCP1</accession>
    <name>A0AAE0JCP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_526580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680378.1">
        <property type="nucleotide sequence ID" value="XM_062828858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCP1"/>
    <dbReference type="GeneID" id="87866012"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="94"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3342585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="433" mass="46241" checksum="0CD56B64B527EDDC" modified="2024-05-29" version="1">MTMTAATTQRALAPLARHQQRLLTSTTSSSTSARSLSALSSTRRPRALLPASTTSPSSAASFHTTPNNAIPSGGFGGAGGIPTYFQKPSLPANTIIRFVPQQTAWIVERMGKFNRILQPGLAILIPFIDRIAYVKSLKEVAHEIPSQSAITADNVTLELDGVLYTRVFDAYKASYGVEDAEYAISQLAQTTMRSEIGRLTLDHVLKERTALNTNITAAINEAAQAWGVTCLRYEIRDIHAPKPVVEAMHRQVTAERSKRAEILESEGQRQSAINIAEGKKQSVILASEAMKAEQINRASGEAEAIRLKAVATAGGIEAVARAIAEGEGAAQNAISLRVAEKYVDAFGKLAKEGTAVVVPGNVGDIGGMIATALSVYGKVGDTQAKAMAKQLLEKQQGEQHEAEKQKALPAGVAKQESPVDDIVKGFDQATEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCP4</accession>
    <name>A0AAE0JCP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_432103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679837.1">
        <property type="nucleotide sequence ID" value="XM_062824981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCP4"/>
    <dbReference type="SMR" id="A0AAE0JCP4"/>
    <dbReference type="GeneID" id="87862135"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="131" mass="14965" checksum="E02E0DAD63C7C867" modified="2024-05-29" version="1">MVAAKKHVPIVKKRSKGFMRHQSDRFMRVDSAWRKPKGIDNRVRRRFRGTLAMPSIGYGSNKKTRHMMPSGHKAFLVSNVKDVELLLMHNKTYAAEIAHNVSSRKRIEIIARAKQLSVKVTNAKAKVTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCX0</accession>
    <name>A0AAE0JCX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_469046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680498.1">
        <property type="nucleotide sequence ID" value="XM_062826993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCX0"/>
    <dbReference type="GeneID" id="87864147"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="11">
        <location>
            <begin position="430"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3342705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="501" mass="55630" checksum="43695ABEAA631300" modified="2024-05-29" version="1">MSLGGQQLLEYLEKLPGTAFRRLYQSPATALAIFRRMLSYHAKVIVRGLLYMPDPFPLTSLDIWFPPEADGKIHRDRTIAALRSLHILQVSPPGKDRTQEIQITTSFKKGLQLAFEGGGEDGSFGVPSSLPVDPTIDIAYLDKYARKKWDDILHYVVNSLGVHGSSEGVSGPKASVKELLLAGRLVERRPDTRTGIGITQAGFTFLLQESNAQVWTLLLLWLEAADHTADSGMDSIDMLSFLFMLSSLELGTAYDTSALTETRRNMLPSLVDFGLIYFPRDTRQFFPTRLATTLTSTASALRTVSSAFTAATANPSGEPGTTTSTSGGPAATPDKTQTTAKGIIIETNYRIYAYTTSPLQIAVLALFCQLNMRFPNMVSGRLTRDSIRQAIGFGITADQIISYLHAHAHQQMVREATVTGKPVLPPTVVDQIRLWQLENERMQTTAGFLFKDFESTEEYAALSRYAEEIGVLVWKNDKRQLFFASKHEQLRDYLKSRKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD66</accession>
    <name>A0AAE0JD66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_550069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680679.1">
        <property type="nucleotide sequence ID" value="XM_062829706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD66"/>
    <dbReference type="GeneID" id="87866860"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="227" mass="24962" checksum="0F9B9BED077A6CBE" modified="2024-05-29" version="1">MSHAFFHYLDGEYDQLWEQIREYGAITPSPPAVQQPVRPSNPTNGRNNSSAHYAREYNPFEDQFGQVLKANSPRYSGAPTPFRTPAVTPAGSPPATRVVIPAATAAVSPAVIPATTPAGPSQQLSRSNTRNIRRRQGLWRLYSSFATVFAETEDSQPRREAWARSLINVREILSIDDTPDPQQNSGEASGSSSQDATSGNSRDGRVTRSLLTPDEEEDELRFPQYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD93</accession>
    <name>A0AAE0JD93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_411503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680152.1">
        <property type="nucleotide sequence ID" value="XM_062823839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD93"/>
    <dbReference type="GeneID" id="87860993"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="274" mass="28603" checksum="FBCCA404C9791EE2" modified="2024-05-29" version="1" fragment="single">MSTPSPPGAPKPSPPAMMPVTPLPDTLCVPPPPPKTAQSAKRARTADEEVRHAHASTASPAASGPLTSLAGTLISEALAKAEVYRSFAAFLDTELARLSVVSPAHAREADHLARTITTALQKSSASSLLSLTPDSTAPAGKKVSTSSAPTSKGKGPISFAEAAARGADSTPASRSTSRSHSSPTRKATLPQSDGRVFLRLDRDSPFANNDAFAIRKEVQSLLRLAPTDIPGCHKVPSGFALVPKDDAVRQTLLAHKDEIGARFGCVQVEVPKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDJ6</accession>
    <name>A0AAE0JDJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_470724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680999.1">
        <property type="nucleotide sequence ID" value="XM_062827052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDJ6"/>
    <dbReference type="GeneID" id="87864206"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3343206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="94" mass="11038" checksum="B475E30A83ECD674" modified="2024-05-29" version="1">MTALVKATYGIFFLGTPHKGPWVEDMASMLNKVDPNHPRLDLVEQLRCNSRALEDQIADFKNICHKYKIVSFYETQQTRRLHWGRSCSELQKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE69</accession>
    <name>A0AAE0JE69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1-like ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_231876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680647.1">
        <property type="nucleotide sequence ID" value="XM_062822198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE69"/>
    <dbReference type="GeneID" id="87859352"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3342854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="701" mass="79070" checksum="31BE2662E3457F1A" modified="2024-05-29" version="1">MTLVLFESDIIGAVKFHPLNPLLTLTVTRTSSASLYQISTPYKQKLYVRLKDYTPSQEYQSRLQQITKALDSARKEDVEDEETQLAVRSHPIRRNPLFAKFFSKPEDRDTLALTRVLTSHQAALHIDSPKGLFLSGEVGTGKSMLLDLLAEGLPTHRKKRWHFNTFMLYALSRLEQFRKSRSQLSMGDQEYSLLWLAKEMVEKSPILFLDEFQLPDRAASKIMNNLFIAFFQLGGVLIASSNRMPEELEKATGGYYHPPTTGGLIKQVFGFGKRQGELFGQTSDFAAFLEVLKARCDFWHMEGARDWRRRESQQIGVTGKSVDKVTTASGAASFQPVFGLSSSTEPQKTTTSEETITEQGLQKPSMYFLPSDPEETWTAAVNQLVGSNSTGQQWTPTSLIVYGRKVHVPRHHNDVTYWDFSELVSSHGPADYLTMASTFHTFIIDQVPVLSLAMKNEARRFITLLDALYESKCKLLIRAEAGPDDLFFPEMRPAKPVTTSTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTSTGNGTEQVAGVVEGDATYSETIAEVFQDSIAPFRPNISEYDPDQDSDFGKEQQVSLTRKVDFNQTVSAFTGQDERFAYKRATSRLWQLCSRQWHARTDEGWWQPLPKEARHWEGKEVSKPLESPLVRLRMGPSEKDKTEIVMGESTVLEEPVGLERFRVREMKEGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE88</accession>
    <name>A0AAE0JE88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine Rich Repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_183751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681340.1">
        <property type="nucleotide sequence ID" value="XM_062821538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE88"/>
    <dbReference type="GeneID" id="87858692"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="73885" checksum="5256A2D08E53123E" modified="2024-05-29" version="1">MVILHHLNTFAAMDHIQTPSPPITPPAHQERLFPAPPSPDECNNMIMGEAQNRQPSPDRASRSSFSSIRENENTLTQTFTHSKVSHLDVDEEVVDDRTPEVTPGPSTLNKIHAFNMIQTQFRPPVTQPNSRLRGYVAPADSFQGWKGIQVKGKLASRSFGDLTILNNVWGSPPKAPRNVTIRPGEAAIERLPAEILSAIINLLVLDVPPNGVTRRNIDLMSLLLTSKTLHFATLSTLYSQITIPHSRIFHKFLTHIAEHQTLGTIVRRLDFCHFNPSQLFSTAAERSQARNLTSETLLRCLELTPNLQEFLVQEHIDQDLSADVLRKLFLGLERMEALDFCGCTSTFFKDSFTAIVTPDWPAQLSIRRLSLHKCLTLPSTVFETILPRLTRLTHLDVAGTRITDAALMSIPYSARITQLNIAKCKLLSARGVIDFLANHPAAQDIVYLSLATDARSHQLFDVEDISKLLPILPTTLKSLSLKGSKMDPSHIDLLRPLTKHLEELSIGRSLLLEDVNRLFVPDETEDVEKQLEWVPHTLKFLDLSDFWGNELDLVYLFNSRCAIMKPFSAPLEVVELAEDVFRRVVKSSATLQRMGWRTSEVGSRGWMVRQKSQDPSVPHDDGSRGWKMGAEAWGMRKIPVARAEVGGMYGSFMFGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JED4</accession>
    <name>A0AAE0JED4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_470765</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681026.1">
        <property type="nucleotide sequence ID" value="XM_062827055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JED4"/>
    <dbReference type="GeneID" id="87864209"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="233"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3343233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="517" mass="57882" checksum="7D04EF2D1268E5B8" modified="2024-05-29" version="1">MAPPTNTTASSEDLATDILAALDKSQPLLSSDAFPSATFVDLKAALDRLASREMVKYDTIERQEALLEPEAEQIAANGSHEARVFEALRQAVEGLSVKELEEAIGDKNVVKIGQGKAFKEKWISKTKDGKFTAVADKINDTTQEQIKIVQQTKTHPDAKILADLKKRKLIRTQNIFSFKIHKGPKFALKIPEEATDLTADMIASGAWKTATFKPYNFKALGATQNGGALHPLNKVRQELRNIFFEMGFEEMPTDKFVESGFWNFDALFVPQQHPARDLQDTFYISDPKAADFPRADSPDDTKDYQAYWDNVKAVHQDGKYGSIGYRYPWSGDESLRLVLRTHTTAISANMLHKLAATRGPDGRPLPARYFSIDRVFRNETVDATHLAEFHQVEGVIADYGLTLGGLMEFMEIFFGKMGLHDLQFKPAYNPYTEPSMEIFAYHKGLGKLVEIGNSGMFRAEMLESMGLPKDMRVFGWGLSLERPTMIKYGISNIRELLGHKVDLEFVQGSPAVLLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEJ7</accession>
    <name>A0AAE0JEJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_187853</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681490.1">
        <property type="nucleotide sequence ID" value="XM_062821600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEJ7"/>
    <dbReference type="GeneID" id="87858754"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF3">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042218762" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3344877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="231" mass="24777" checksum="B7210964DB4AB122" modified="2024-05-29" version="1">MLPSISLLLAAALGTSAHYTFPKVRANSGTTADWQYVRRADNWQNNGFVDNVNSQQIRCFQSSHSPAQSTLSVAAGTTITYGSAPNVFHPGPMQFYLARVPDGQAINSWTGEGAVWFKIYHEQPTFGSQLTWASNGKSSFPVKIPSCIKSGNYLLRAEHIALHVAQSSGAAQFYISCAQLSITGGGSTEPGSNYKVSFPGAYKASDPGILININYPVPTSYKNPGPSVFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG03</accession>
    <name>A0AAE0JG03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_549026</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681916.1">
        <property type="nucleotide sequence ID" value="XM_062829624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG03"/>
    <dbReference type="SMR" id="A0AAE0JG03"/>
    <dbReference type="GeneID" id="87866778"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000010">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3345303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="136" mass="15392" checksum="9AF51E808E698349" modified="2024-05-29" version="1">MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVESYLVSLFEDTNLCAIHAKRVTIQSKDIQLARRLRGERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG18</accession>
    <name>A0AAE0JG18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_425687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681622.1">
        <property type="nucleotide sequence ID" value="XM_062824593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG18"/>
    <dbReference type="GeneID" id="87861747"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="196" mass="20515" checksum="E53AE46ED5E1311A" modified="2024-05-29" version="1">MPTPTMPTMPTMVGRRSRSGSGVSLHGSVGGGGGGGLRRRAGSGASRVSATSAGGRRSRAGSVASGGGRRSRAGSVAGTSVGSSGSDDNCCGLMDNEKNKKNKGKITIPVGRRKRSRSVVKGKMKQQQGGSAGGGSSSEGAKEREEKVRKSGGSHHQFHRLKLLLERESVQRKLMLEREMSLQRKIDANPDFSYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGQ3</accession>
    <name>A0AAE0JGQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_146652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682418.1">
        <property type="nucleotide sequence ID" value="XM_062821016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGQ3"/>
    <dbReference type="GeneID" id="87858170"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
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    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042170723" evidence="10">
        <location>
            <begin position="21"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="249"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3347336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="719" mass="79136" checksum="6B4D6BA5DC66019A" modified="2024-05-29" version="1">MVLLHIPAFILGLLTLGATAAPFPENHVRHLDTRQVPGTHALHERAMPHWRRKWEKRGRVPPNTLLPMRIGLKQANLDVGHDLLMDISDPKSRNYGQHLSRKDVLEMFSPTSETVEAVKKWITSSGIPQDRISRSENNQWVQFDANATEAEDLLYTTYHIYEHLPSGSKTIACDQYHVPHHVRDHVDYITPGIKLRPDPARVRASKRSQRRAPSVRTQERRGFRPTHHGLIRAGFDTLPPLNESVCYKYVTPECVRAQYGIPEGTTATPGNELGIFEGLNDHYVKEDLDAYFSSIYPKIPNGTYPIEKLIDGAIGAARTSDEYGAESNLDFQAAWPLIWPQKTVLFQTDDQYYETNQTEQDTPFKGFWNTFFDALDGSYCTYSAFNETGDCKDPACLDPIYPNPFANSSIPASDKYEGPRQCGIYDPTPVISISYGGGEGDLPASYLQRQCSEIMKLGLQGITVVMASGDYGVGSYPGDDGHKNGCAGEGDMEGRVFYPDSDASCPYVLAVGATEWVQPVPANASNSTANHPGGPLMERATSRFASGGGFSNIFPSPFYQVSAVTSYFAKVASQLNFTGYDIPEPVATNFTISNDTDLGSGVYNRAGRGYPDVSAIGDYYLFRFAGSWHEIGGTSLAAPVWGAVLTLVIEERVKVGRKGRLGFVNPLFYAHPEIFNDVTVGSNPACNSSGFPAAEGWDPVTGLGTPNFPKLLDLLMSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH03</accession>
    <name>A0AAE0JH03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cellobionic acid phosphorylase</fullName>
            <ecNumber evidence="11">2.4.1.321</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">4-O-beta-D-glucopyranosyl-D-gluconate:phosphate alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_153553</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible phosphorolysis of cellobionic acid (4-O-beta-D-glucopyranosyl-D-gluconate), a probable step in cellulose degradation. May be part of a metabolic pathway where cellobionic acid is converted into alpha-D-glucose 1-phosphate and D-gluconic acid to enter glycolysis and the pentose phosphate pathway, respectively. Produces 4-O-beta-D-glucopyranosyl-D-glucuronate from alpha-D-glucose 1-phosphate and D-glucuronate with low activity in the synthetic direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = D-gluconate + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11564"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:76825"/>
            <dbReference type="EC" id="2.4.1.321"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 94 family. Cellobionic acid phosphorylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.321" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682784.1">
        <property type="nucleotide sequence ID" value="XM_062821113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH03"/>
    <dbReference type="GeneID" id="87858267"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11748">
        <property type="entry name" value="GH94N_NdvB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000046">
        <property type="entry name" value="Cellobionic acid phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.40:FF:000006">
        <property type="entry name" value="Cellobionic acid phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH94_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052047">
        <property type="entry name" value="GH94_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037814">
        <property type="entry name" value="GH94N_CBAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94_b-supersand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469:SF2">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="GH94_b-supersand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase 94 supersandwich" evidence="14">
        <location>
            <begin position="81"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase 94 catalytic" evidence="15">
        <location>
            <begin position="319"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3347702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="791" mass="89750" checksum="B3A27AE614E4302A" modified="2024-05-29" version="1">MTRKIQTLIRPTHGGERYELTNPTAMPKAAGFLWNQKMMIQITCRGFATAQFMQPEPAKYAYAPNIEAKTFMQPEPNYYAHHPGRFVYIKDEETGQLFSAPYEPVRAPQDRFVFSAGKTDVSWVVESMGVRVEMTMGLPTHDVAELWTIKVKNLSSRPRKLSVTPYFPIGYMSWMNQSAEWNNDLNGIVASCVTPYQKAADYFKNKYLKDKTYFLCEIPPDSWEASQQAFEGEGGLHNPSALQDRNLSGSDARYETPTAAVQYRIALDTDEQQEYRFLFGPAYDEAEIGAMRSKYLSKEGFEQTAADYAAYMARGRGCLRVETPDKDLDNFINNWLPRQVYYHGDVNRLTTDPQTRNYLQDNMGMNYIKPEVSRRAFLTAIAQQEATGAMPDGILLVEGAELKYINQVPHTDHCVWLPVTLEAYLNETGDYSLLKESVRSANGDEFTVFERFCRAMDWLLKSRDHRGLSYIAQGDWCDPMNMVGYRGKGVSGWLTLATAFSLNIWAKVCDHEGEVDLANRFREGADACNAAANEHLWDGEWFARGITDDNVVFGIKEDKEGRIWLNPQSWSILSGAASPEQIDKMLPHIDSHLNTPYGIQMFGPPYTKMREDVGRVTQKAIGSAENAAVYNHAGIFFIHSLYELGAQQDRAFTLLRQMLPGPTDADYIQRGQLPIYIPNYYRGAWKEFPRTAGRSSQLFNTGTISWVYRCIIEGLCGLRGDSEGLLIRPQLPSSWNNMKVTREFRGATFNVNIRRGNVKKVTVKNGDKVLPEPHIKDIKPGQTYNLTVVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH76</accession>
    <name>A0AAE0JH76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_441221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682693.1">
        <property type="nucleotide sequence ID" value="XM_062825511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH76"/>
    <dbReference type="GeneID" id="87862665"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="216"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3347611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="334" mass="35308" checksum="3CAB6127D7859AA6" modified="2024-05-29" version="1">MAAPATSVKEVIQKKPEGLDLYARFALAGALGCSVTHGAFTPVDVIKTRIQLDPATYNRGMIGGFRQVIKNEGIGALATGFGPTFTGYFVQGAFKFGGYEFFKKQSIDLIGIEKARQNRTAVYSVSAASAEFFASVALCPLEATRIRLVSTPGYAKGLVDGFTKILTTEGVGAFYAGFGPILFKQVPYTVTKFVVYEKVAENILAQFDKSKLSGSALTGINLGSGLIAGFAAAIVSQPADTMLSKINKTKGLPGESTVSRLAKIARELGVRGSFAGLPTRLFMVGGLTAGQFAIYGDIKKALGMFMSCPRICPQQYQTANLVITGATNGVEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHE4</accession>
    <name>A0AAE0JHE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_558522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682327.1">
        <property type="nucleotide sequence ID" value="XM_062830104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHE4"/>
    <dbReference type="GeneID" id="87867258"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="93" mass="10946" checksum="E246DC23B68989D8" modified="2024-05-29" version="1">MPLLSPKKPRRHTLQRGCLEVTSTELFKCGRCGHTTNHRGNHLEHLRIKRPCPEMEKPTMYECKYHGPTSLDREEHITHLKDSSSHRQVYDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHL3</accession>
    <name>A0AAE0JHL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Quinate repressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_162194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683082.1">
        <property type="nucleotide sequence ID" value="XM_062821259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHL3"/>
    <dbReference type="GeneID" id="87858413"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000019">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003173">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="9">
        <location>
            <begin position="576"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="8">
        <location>
            <begin position="715"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="10">
        <location>
            <begin position="863"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="898"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3348000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="917" mass="100668" checksum="57576FB2E1426537" modified="2024-05-29" version="1">MNTIPTRHVGDIATRDPLPLPPISSSSGMKRSFATMAMLYANDSDTGNSDDANANANARRPPRPLSNSPSTSNYRVGSWSAPNSPPRRRALPHHPITANFAPDASIVIAGIRGAGKSTLAIMASSAMKRKIVDLESEFHHLTGLSSSNYKKRHGPADYGRRQITILQNILKLHRTRAILVCSWLERDVQAMLQDFSTSNPVIYVLRDAKAIEAHLKGYDKSKVGALLDATSAVLRRCTRFEFFNVSEENLDTHSGSASPPAVPDQRHTAPYLTLKRAERHFLKFLSLILPKGTIPFLESAFPLASVPVEQRRFTYALALPISAFLDKGVDIQELEAGVDAIEIIVDHLATSESGPTGPLDLAPHRASEISRVVGEIRRDTVIPIILHVVFPERALYEEALLALYMAYLSHALRLAPDYLAVDLRLDSGLLGQLTAVKGITKVIGNKQLAQVNSPLWRDSSWLQAYQKAQNTGCDLVRMTRPASSSRDNTDIRQLQVAVEAAGGPKLPLIAYNTGRLGRTSMSFNEILTPVTPESFKEDALGLQDSAHRHLQPPLTALEATQALYSAFVHDPMKLYVFGANVGYSLSPAMHNAALKACGIPHHYRPLSTNNIGTLREVISDPQFAGASVGLPFKVEIISLTHSLSRHAKAIGAVNTLIPARHLTVDGGIPDEVSMFNNISQAGPVKALYGENTDWIGIRACLRRGLSPANAVRSTSTGLVIGAGGMARAAVYAMLQLGVKKILIFNRTFANAERLVLHFENLLARDALPLLSTGPRSHDNTCFHIIRSRDEPLPENFKNPTMIVSCIPTHTVDNTPDPEFTVPLHWLDNPTGGIVLELDYKCLTSPLLEQTRREAHRGWVAMDGLDLLPEQGFAQFELFTGRRAPRRLMRREVLRAYPDDQEQSHTAPRLNRIATQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHP4</accession>
    <name>A0AAE0JHP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_386221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682771.1">
        <property type="nucleotide sequence ID" value="XM_062823712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHP4"/>
    <dbReference type="GeneID" id="87860866"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="121" mass="13274" checksum="FBB3D2ED6F147326" modified="2024-05-29" version="1" fragment="single">GGPPKRHQLVNLDREDIDPQRIEEACQARMAILDRDLAGNKISQAAHDLDRTDVDKFRVLMEKSNPQAVKGAVSEAKNLQDTKRKLEAAYASELEIPSLVDRARYAGLLDGDPVANALGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHU0</accession>
    <name>A0AAE0JHU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_460643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682582.1">
        <property type="nucleotide sequence ID" value="XM_062826545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHU0"/>
    <dbReference type="GeneID" id="87863699"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="92" mass="10366" checksum="6F6D8C26E4DCF8F3" modified="2024-05-29" version="1">MDSSNPLSDREKAFENKYIHDKECVPSLHHTSSFEPIADKRVCRRQMAKDRANKKTQTESSSKDSSSTPREQEEGSGSTYKDVITELSAMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JHV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_570378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682597.1">
        <property type="nucleotide sequence ID" value="XM_062830449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHV7"/>
    <dbReference type="GeneID" id="87867603"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="254" mass="28208" checksum="5843B8964439B1FE" modified="2024-05-29" version="1">MEPTSTSKFATEMAHGMQALSITPNQSAIKSPKSGHNVAVRSALSDPGPSTMHSQSSPLRPSTQTTEPTMPGPSSSPAGPKVNITFIHPSRAQEAEHFPHICQHPHPFPGHYKTHRHRPISQSARDRPCEKHTAAQHHMRNRHSTLMAMGGNMDHPLPKHCIRNRMKLEHMREQRRDLIAKLRAHINVRVDTLNQELTLCSLSSLSLTEEPKKTLSAPEDDLEHLLAGIRERTGLMREDASVGGSGEDEDVMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI06</accession>
    <name>A0AAE0JI06_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA-like thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_170684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683340.1">
        <property type="nucleotide sequence ID" value="XM_062821362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI06"/>
    <dbReference type="GeneID" id="87858516"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="233" mass="25339" checksum="A084911383F9817B" modified="2024-05-29" version="1">MTHFQIKVVSDIICPWCYVGKARLERAIKLYKDAIPGGANDTFTVTWHPFYLDPSLPKTGGVDTKAYLGKKLGSPERLAMMHARLKAIGEGEGIKFSLNGRIGNTRNAHRLIQLAKTKSNEMENKTAAALFQLHHEEDGDASSNDMLIAAGKRAGLDGAEVESWLDSDAGGDEVDREVAEAQRKGIHGVPNFTINGRSELSGAQDPETFVQEFLRVKAATSDVSERPSDGPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JII4</accession>
    <name>A0AAE0JII4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_442000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683577.1">
        <property type="nucleotide sequence ID" value="XM_062825556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JII4"/>
    <dbReference type="GeneID" id="87862710"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="236"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3348495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="437" mass="48106" checksum="29943CF66C596BA7" modified="2024-05-29" version="1">MSVDAEGQGESSSLGSVVMVAVEVHSRPNTPDAARIASSQHVGASESVDTAPKCQKIPRRSTSFGSSAELEEEDVPVRTRPTTVGSPQHHSPFKSGHDTRTQRSLHGKHKVQTNNWPESSPKSAEAATSPGQDPSQGNGLEEQREDKYHHIWQDMRKELYQQNLVKLISRQRPGALGYIDKMSGLATGRKESLMSANFGYRIHFGDLQRIHIQYLHSKLVNLAVSAHLHDSEWRSGGKAEQIGQVMKEYIQAVKDHEYMGKYANASDDPFIATSQRLYDKIFLESAMTAEGYKMPEDFLAPPPKHKPRPQHETPAQLANLLTQHATSTGPWERDNTNKPAAALISTRTRAWKRAYWTRIGAALIGGAFLIAPMWILALQRNLFIHLGVATACITAFGFSISLYLEAVDGVFAATLAYAAVIMVFVGIVIEETGAKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIR2</accession>
    <name>A0AAE0JIR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_555511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683697.1">
        <property type="nucleotide sequence ID" value="XM_062830031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIR2"/>
    <dbReference type="GeneID" id="87867185"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="867"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="871"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3350402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="888" mass="94956" checksum="830B61C74BA4EDDB" modified="2024-05-29" version="1">MNMSSPPTPGSGHGHGTEGIGRPGSRPEKRTCITCRARKVKCDGRPDKCTNCERLGFTCSYDPNTIVTTSIDAGVGPSHSITSHEAFSIDRLVPTETEGSVSTSTTTTAPVVGLRRIRARQACQSCHVKKAKCSGIINKSGPGGSGSGGYRGCERCRALGIACVLRKGKRGLALPGMNNSSLGDAGEMILDDGGNGMHLDDPRDLDDDMNHNGSITGGRSTASPAPIPSNNPDASGRIDLSQPDDPIVKRAFDNYFRHVHHVPMFSFLHRASLMERYDAGLLDRALLLAIVGIAALLTDLGPSVSVADPELFSNRCIDEAASICTSELENRSITRLEALVIVVKHRILSKRFSAAFMLHALTSRFANVLRLNVENPALCFLAQESRRRLMWSIYMIDAWFANGQTDLALWPDPERQIRVQLPCNERNFDFDLPEVTEPLRQPPPSPSGQPVQLPDAVGFTALHIRMHWLRTRILQLSLRVVGANPDPNELMQLPLRCAEFKAELDSFEARLPPSFRWSESNLRLRSYSSRLAIFFTTHVWWRQCHLDLYRLFLPGLKEALSGSSLAQLAGSTVGSPAAQGQGQWQGQQGQNGQRQGLVEWARQECYKHARAMADMFAQVLALGESSVPLADVDLPGCALQCGRVLYHSFQTRDGGQSPAPSAEGVREMVSVCLRVARLACPGPASRAIQSDIEKLLAEGLPISQVQVTGQTPRPNDLLTPTPGPAPFSPGPPGAFSMSNVPLPGPIPLINDPHELGPPQNLLPAMAPPVPSQHAQQAPQMLPPVSNSGPAPVGVGVGVGAGLGPGPGVAPSQASQITTGSNAFEEILNVNGINFGGGGLGMNEFFAPDAWGLGLSPFPMGLTGGEWTVQGQGQGQGGGQQGGFHGDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ12</accession>
    <name>A0AAE0JJ12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_462521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683227.1">
        <property type="nucleotide sequence ID" value="XM_062826646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ12"/>
    <dbReference type="GeneID" id="87863800"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042252117" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="11134" checksum="DD8E60E6BD9B4FA6" modified="2024-05-29" version="1">MRFFIFFLSLLSMPTSSTYLYYTLPETKFMFRRGSRYFVKLAFILRTTTEAMISFRRNHIHHLSYHQNLVHRPSPRFIQDIMIQRPKNQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJB7</accession>
    <name>A0AAE0JJB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">B0H65DRAFT_97202</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="31">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="31">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684009.1">
        <property type="nucleotide sequence ID" value="XM_062831629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJB7"/>
    <dbReference type="GeneID" id="87868783"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 31" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="106"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KAK3350714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="365" mass="40361" checksum="AB2E778F3A58A55D" modified="2024-05-29" version="1">MCPSAPPERNGRQAPASPKQKFAIINKTTAQPNPSATNLSPDTNRTFNPRDPLENYSTRLMDTSPQSPPTKKRKMATSTSTAAAASSEQEQEHQFPLPPILTHPSAAPPTLITQGAEGRLYKTTFFSPDIPCALKYRPPKPYRHPILDARLTKARLAFEAKVLERCRREGVPVPAVYAQNAAAGWIAVEWIEGAPVRVKINEWLGQRPKNEEEEKAALEKDQGPLVELMKRIGSAIAGLHRTGVVHGDLTTSNMMLRPPPVKTTTTTEEGETNGVSSEEAQEKAKLLEGDVVIIDFGLANQSQSDEDRATDLYVLERAFASTHPRAENLFEHLLESYKQSFKKGASVLHKLEDVRMRGRKRSMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJQ3</accession>
    <name>A0AAE0JJQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_439944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684285.1">
        <property type="nucleotide sequence ID" value="XM_062825454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJQ3"/>
    <dbReference type="GeneID" id="87862608"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="34"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="129"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="312"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3350990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="373" mass="41063" checksum="A98FAB152BA57582" modified="2024-05-29" version="1">MVKVLAVLYDGGKHAEEVPELLGTIQNELGIRKWLEDQGHTLVTTCDKDGENSTFDKELEDAEIIITTPFHPGYLTAERLARAKKLKLAVTAGIGSDHVDLNVANKTNGGITVAEVTGSNVVSVAEHVIMTMLVLVRNFVPAHEQIQEGRWDVAEAAKNEYDLEGKVVGTVAVGRIGERVLRRLKAFDCKELLYYDYQPLSPEKEAEIGCRRVLDLEEMLAQCDVVTINCPLHEKTQGLFNKELISKMKKGSWLVNTARGAIVVKEDVAEALKSGHLRGYGGDVWFPQPAPEDHPLRYAKNPFGGGNAMVPHMSGTSLDAQKRYAEGTKAIIESYLSGKHDYRPEDLIVYNGDYATKSYGERERAKAAAAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK03</accession>
    <name>A0AAE0JK03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_389409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684450.1">
        <property type="nucleotide sequence ID" value="XM_062823735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK03"/>
    <dbReference type="GeneID" id="87860889"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="81" mass="8306" checksum="A40F17D10B75DF35" modified="2024-05-29" version="1" fragment="single">MAGPAPSLPATMQALRITSFGAPYTLTTIPVPSPSTLRPHDLLVKVAVASHCHTDTIIRLGAIPSIPLPLTGSHEGSGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK77</accession>
    <name>A0AAE0JK77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_537323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684444.1">
        <property type="nucleotide sequence ID" value="XM_062829071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK77"/>
    <dbReference type="GeneID" id="87866225"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="239"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="4">
        <location>
            <begin position="382"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="468" mass="51295" checksum="18804D3073A22F39" modified="2024-05-29" version="1">MSATTIAQKGIDALAKGDYATAITNLDKALESSNSPVWLLARSKAHQKAKNLEAALHDAELAYHAAAERGSGTSRSHMIQAQYRRAVIYYQLERFADADCCAKWSMLLAEGRPAREDDGVEKRVDSEGNYTVTYEEYLADKDNQPKPKTGNALAAAEKGPYATDWNMAFSWRSQALGRLKKLPKDHPGWKVNVTKIPPKPEQKKVKSPEPAESTSEDEVQEQKAPKKEAPAPGSVPDEKMKLRVDFYQTNQTVTVSLFVKDVKKEDLKVEFGKHQSTQVRISPILREAAPYVKPGDREATSTFVLAGEIDPSASKWSASPRKIELVLQKAAPGIKWGRWGDEKIGTVESDDQEPATTAASSSAASTAKPATSSASTPAKLPAYPTSSKSGPKNWDSLPVDDDDKEDGQDINGFFKTLYKGSTPEQQRAMMKSFLESNGTTLSTNWEEVKDKVVPTVPPEGVEPKPWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK91</accession>
    <name>A0AAE0JK91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_109661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684474.1">
        <property type="nucleotide sequence ID" value="XM_062820555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK91"/>
    <dbReference type="GeneID" id="87857709"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3351179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="556" mass="60583" checksum="03DDC731190A816B" modified="2024-05-29" version="1">MANTPLPDHMQPAYVDRIFKPLESRISELLDEFCPANQGTERLNDVKKLVVNYVVLQILTQTFDPNLCVTPRPKDLAHAEAWVENYCHDSSIHLGGEPPQITGLAGHGKEFYSTISHILADIVPALNSQALSSRYYGFVTGGVHPVAQAADNVVTALDQNVQVHMPSTHSISTVVEHHALSMLRSLLVLDGFQGKTFTTGATASNIMGLACGREAVISARVPDYAKTGGVGELGLLGACMAAGVKEVQILTSKGHSSFYKAASIVGLGRAAVKDFGVPDTSWVLDLKAVERELKREGVASIIVVSAGEVNTGQFGTTGETMKELRKLADRYKAWIHVDGAFGIFARALPKVDRFAKLRERTAGLELADSIAADGHKLLNVPYDNGIFFCSKPEVMTQVFQNPNAAYLAPVASTSRSGTNTEIQSPLHVGLENSRRFRALPVYALLLHLGRENMGEMLARMVDLARKIAAFIRDSDKYDLLPDEATADIECTHIIVLFKAKNPDLNEVLVEKINETRRMYVSPTKWNGENAVRIAVGSWKVDVEEDLAAVRSVLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKJ7</accession>
    <name>A0AAE0JKJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_457568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684629.1">
        <property type="nucleotide sequence ID" value="XM_062826359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKJ7"/>
    <dbReference type="GeneID" id="87863513"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="261" mass="29018" checksum="FBB6F0DA2E0EB816" modified="2024-05-29" version="1">MSSELMAAYWQAPPMARTLATAILVTSITAHFGLLPIDWIYFDESRLFKLPPEIWRLVTSFLLSSPQLGIVLDPYFAYQYLSQLETTNPKFQRKEDILWYLITVGGFIITVNRIFLGGYFFLQGLIVALCYTAVQDARGAKANFFFFTVPAQLIPYCMLLSSLLMNPMAIPLQVTGILAAHWHDFMTRLWAEFGGGSSLLPTPAFLSRFVETPRVFRREYGTAIRPGPGAPSTGSTTGASTGSVLPDSWRTRGSGHRLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKM0</accession>
    <name>A0AAE0JKM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_116467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684684.1">
        <property type="nucleotide sequence ID" value="XM_062820661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKM0"/>
    <dbReference type="GeneID" id="87857815"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042062439" description="agmatinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="392" mass="42017" checksum="2DE1014D549EAFF2" modified="2024-05-29" version="1">MLRSSFIASCLAAAVAAHGDHSQKVVAGPHQGLWYNTLPGDGGTQADSVFSGISTFGRLPYLPCLASKDINYDIAFIGAPFDTGTSYRPGARFGPSGIRQGSRRLNLYGGYNVPLATNPFNSWATVIDCGDIPVTSYDNTFALSQIEQGHHSILSRAPTTDSHQPGPSLSGKTLPRVITLGGDHTITLPLLRSINRSYGPVSVIHFDSHLDTWRPKVFGGSPSEVASINHGTYFYHAAQEGLLRNDSNIHAGIRTTLSGPSDYENDGYCGFEIVEAREIDTIGTEGIINKIRARVGTERPVYLSLDIDTLDPAFAPATGTPETGGWSTRELRTILRGLEGINIIAADIVEVAPAYDTNAEHTTMAAADALYEIMSVMVKRGPLSVTSAPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKQ0</accession>
    <name>A0AAE0JKQ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_110394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684491.1">
        <property type="nucleotide sequence ID" value="XM_062820565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKQ0"/>
    <dbReference type="GeneID" id="87857719"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041769754" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="455" mass="48954" checksum="E90C2DF3DAF44754" modified="2024-05-29" version="1">MKSVSLMSALASIASLSAASPTPTEQEQPHKRADLPAVTVSGNAFWKGKERFYIRGIDYQPGGSSGMTDPLADLDTCKRDVAEFKKMGVNTVRVYMVDNSKKHDDCMNLLADAGIYVVIDANSPLYSLNRFDPHQSYNDKYLQSVFATIDAFAKFDNTLAFFSGNEVINDVVNSTLAAKYVKATTRDMRQYIGNRGYRKIPVGYSAADVSQNRMQLANYMNCGTEDERSDFFAFNDYSWCSSDFVSSGWDQKVKNFTGYGIPIFLSEYGCITNTRDFGEMGALMSDKMTSVYSGGLMYEYALEANGYGIAKLGPGSKVEEKPEFANFVKALSKYPAPTGDGGFTSTTKAAACPTKDSNWMVDSTLLPAIPEGAKKFMKDGAGTGPGLKGEGSQQAQGTSTGDAQPGSGSSTNTASPSSSQSENAGSTRGIGPVDKAPFVVTGLVMFFTLTGTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKR6</accession>
    <name>A0AAE0JKR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RFX DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_546569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684840.1">
        <property type="nucleotide sequence ID" value="XM_062829453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKR6"/>
    <dbReference type="GeneID" id="87866607"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="198"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="797" mass="89244" checksum="2FA8AD44780A7F5E" modified="2024-05-29" version="1">MLTACTDPLALTKAKKRPRSQGSTASIHSAATQPNLDHAFTDVPEVYQSQWIPNDHSRTRDLGHPTAQMTQDDMVLASQLHTSREFAMDSQVNASMQNVQYHGSHSMSRQSLSADSFAGNTSFVEDSQMVDHDGNNDHGSYVGMTSQSKGGSRSSANNEVEMRQLYVANRHRNLQEVAEELHGNERGPNSERTRQVFAMLWISQVCSKGKGSVPRGRVYANYASRCATERITVLNPASFGKLVRVLFPGLKTRRLGVRGESKYHYVNFQLREDQPDVRDVSTQPQVSPTEEQSFSQTFNTAPDNTMTTERPVLPTPDLGQQPETRVRRPHEYVHRLYNQVQVANIDQLSTTVTKTVQRLCFAAETEETFQQSDPLVLPRIEPFLPKNTDPDAAKSLAALYRSHCTSLVECIRYCKEKTFFHLYTSFQGTLTMPVQKLFSNPAVAPWIEECDFVLYQRMMRIVSSLVLQVVPKTVLDTLRNIADKLVPHIRDSFQGQPPHVLKAKEAPATLFAGLLDRVLRVNLTAHAAANMLSNPANRDLMYVEWINIINLRKVAESVPSRGMDDVVNLLLKEMRDLLDPVNIPWEIEGLTLHGEMAMRNGRQSQAGNPEESTASNVLDRWVSFLRSLPSHFPYASHTDIVWCVQRLGTAVMRDITLGQGKSFGSWWVTKCFIDEMILFLAEYGGFLKQKSTHEYTLLVSQQQGASNEASNEASRYRSGSDDSSASRMSESQPDRARFPVAASTATQPSVHDDSGIGIRTPDEDSPIQKFGFQTTTANSQDIFAGTELQDEDHLADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL33</accession>
    <name>A0AAE0JL33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_420244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684718.1">
        <property type="nucleotide sequence ID" value="XM_062824265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL33"/>
    <dbReference type="GeneID" id="87861419"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="936"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117951" checksum="42A4ABD789BF27A7" modified="2024-05-29" version="1">MGVKPVSFVTNMTMSSYSTLPSLQEQATMMDTTVLHAAYGMAWLEQAAPPFTTGDYALMPFSPENTTSHYRPNENLTAVTDMYTVEVDCWQAAMSKLAPRNSYMLDNGHGCAVNVSLFQTNPFQNDTSLILYVGYYESAILDYYLEGPHCSTNSTNQFLTFYAYRSKDEQGMNYETNITASFCEASFYKQPVTATVSAESGRPLNDSVVAAGPKERLSENEFNSTAFGYITSVGMPPITPTRDYPAATTFEPWGSLSGENIAGPTMPMVNLALGLSDDPAIEFQHAAVMERAFTTAYKTIFSAAISQLTSKARDPQQMTGKTTYALYGVVVSRTISAIVEGLLVLLVFLMGGTLYTSVRTKSKLVSDPATIGFALRSVKTSRAVRNRLAMEDCSDAATLQRSLVAERFFLEQGITGNSLEMESKSHETSTFEGRRRSIEYTPVRPKELSPLTGCLLVCLLLSGAGVLIYFKKKEQSLGGLPRPSENFEVLQLLENYIPTILTTLLEPFLVLLTRLFCILQPFNALRNGKCNPERTLEAKYTSLPPQLVLWRAIRSRHFLLTILCVMALLVNVLTVALGGTFNELPVKIQYPTTFSQVRAPELSRDTILNTTYMYNRVYQDHYYAASTNFSHNTTLPPWVTTKYTFLPVEEKETVQQAGSSNLFRSTLRGFGAEAKCEPLSTSLSDPKAYANVSELLNGFHTDGSPGSTFNFLRENGTWQSCYPMELIWGANATGLSAREVVSPLSIEYGNIGNKAYEDHFCEDRFVVGWLRVNSEDPNNTFRSTFLQCQAVLKTAMFDVDFDKAGHILAYTRNGDFDDITQFMSLNMSQTLVRQANRLTNDSSRPFNYFGWHNVSMVVDWWNYLLKSYLQSSDLVDPTLDVPKPEYAAPAVEELYQRLFAILLGQNFDMFKEASEKTDVPGVVIVTETRIFLDDTAFMLSVVILCLNAAVLVWFYAAQSEAYLPRLPSTLGSLLAYTAASRAVTEYGNGNDSDKESGHRKALPGTFSFGRYLGVDGNVHVGIEMDPFVTPIDGTMLRRRSTARSWFQKKVGKSPSQVSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM91</accession>
    <name>A0AAE0JM91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_126724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684892.1">
        <property type="nucleotide sequence ID" value="XM_062820751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM91"/>
    <dbReference type="GeneID" id="87857905"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31781" checksum="DA872BB7D06081B1" modified="2024-05-29" version="1">MWWWLTALSGSITPLFLVLSPILSYGDQVHSMHKAKSSAGFSLDIPLIMLVASLLRIFYYPGAKYDTALFIQSLIMVGVQVVLLKVALDHRPVPSSRGGDAAVPFAKAQDEEYQRPYNFWQWKSPKPYWQFVFYLFAGLVACQILLSPFESLYMSYSSLIGYIGLSIEATLPIPQILVNHKSRSSKGLRVSVLAMWLAGDAMKMFWFFTSSSEIPWSFKGCGIFQACCDSYLGVQYLMYGSGEGVSGAFKDYPLENYPVPGSHSVVTGREGVAARRTSNADKRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM96</accession>
    <name>A0AAE0JM96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_4941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685605.1">
        <property type="nucleotide sequence ID" value="XM_062827773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM96"/>
    <dbReference type="GeneID" id="87864927"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="205" mass="22335" checksum="FAA24770483D2E0B" modified="2024-05-29" version="1">MDNLSAAIASSSYVLKLGCHMVPISDEDSGPRLFTHSRSATKIEIILAVNQTRRLPCTCLSPELEFPSPLQLLGGTLHQFPLKVAFKRAVLLPNGIWCADNGSLGRETLLPSGTSASPRNMVVRQSDIPRAVPQRKDLEKDNEPHAPPGDKVLEAGDGLMMDTSQPEELQAWPAIISNLHGRLVEGQIWPATLSPSRRLVSFSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN69</accession>
    <name>A0AAE0JN69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_535518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686085.1">
        <property type="nucleotide sequence ID" value="XM_062829028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN69"/>
    <dbReference type="GeneID" id="87866182"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF14">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="137"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="714" mass="80319" checksum="C23CC55A2FA113BA" modified="2024-05-29" version="1">MEFMLSGYDSASVGAADDDNDNLLEVRALGRPFTGFAHSLGRSITGTPFQTLDPAEDEIIGDTSINRPRSLFSGRERPVIIDPDLPRRWLRSCLEDHKDICPLNRRQNRTASTFRLIDTSTKAVVEFRGHRLGDIQYVALSCIWGNGHKITPRHDTVTQLQLTGSLPVAGPQTVLDAIKFTSDMGIRYLWVDAFCIIQDDENDKAAQLQLMAEIYQYALFTIVAAAGNNAQAGLPGISIPREAVQQKVLVKKAESPELAPIWLISTLAPRDKMREYAWSTRGWTLQEKVLSRRVLTFTDKRLLWRCRQCKKWEEIDTETASDLSCSLRYEGTGGRSLDLDPFMEPNPSRIGQAEITASPWQNLSSLISEFARRDLIVQGDAHDAASAILREYTIQTGVQFLWGLPADARFELALCWHYTTKPSELDPHAGKPLRRRQEYTTLPTTSLQQRRSRAGRGWGGEGRLICRIWIIPKCWFHQADSQNTRPEDIETPIVAYVLKNTPLELVRTSTLTPEADTHAPTSHKQNDDPDASLVTLDMIVTELPDLTFDRLSLIPDDQILFFWAETAHFFLSPLSKSNHSSDRGRPIYDEKGEYCGDVGPLPGAVGAVDDDADEEDDFGRDSSSARDAKGTSTSTSNNNQRAEFIALRRFTYICLVLQVERREGIVYRRPNSVICSPLLFMLHTRLFHLGVWIESMNKRHSKLLDAAPGGMQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN77</accession>
    <name>A0AAE0JN77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_547057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685372.1">
        <property type="nucleotide sequence ID" value="XM_062829484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN77"/>
    <dbReference type="GeneID" id="87866638"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="284"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="744" mass="84577" checksum="F3B7B84BF406EEC2" modified="2024-05-29" version="1">MASQDFRLCIFCRELEPASTACPLVKKSQAETNQADFLGSEDQFNELSPLSPSDERLLKQLQDKPSSLCKRCTDYNPLRAFELAEPLPSGLLPEDDDGFRDYFLRLKASELDLGELGSLTLSASCPFCRLIYRIMPTKGIRPDTKGMRLTPYRAYVRHTGWEYLPEKTRAQSAIFLGLRHLSHIVHGIQVPLLFSDGEPGVRSPEMTGPAICLATEDTFPGRQEYNGRLVEPFVDFEFAKSGLDVCWKNHKEYCISTKPEELFTTKMIDVFERKVVPYPEGCEYVALSYIWGRVMPEEGALEKRTLPQTIEDSITVTRKLGKQYLWVDALCINQKPWKTLSVQEQAEKTQQLAMMDLIYQCAAVTLIALSGQDSNAGLCGVTRPREMQLQETINGRKLFTIPAVVEDEMAASTWDTRAWTFQEGMLSKRSLFFSDKQLGISCQRSGAPDAYDPSCYSHLSNRPMDSFRQLMNGFNLTDTNISVTNPQRILLYTGLIMDYTRRQMSRSSDSLNACLGLLSALQRRLFPSGFEWGLPLRELPLTLGWSHDWAFPEPKRLQKDSPPWDIARPQRREGFPSWSWCGWEGHVTFGQTSLQDGSLVTVGRGRGGREVTSDMVPEFVGCEGKRLTVNGYVCKFYIRTEPFSEAFLTKPGNEGEKPFGIVSERNFPHPYTLKTGEYEGLVVERLRHTQDGKFVKDTVYMIVLDWVQSQDGRGEVAERRTFVRVQSDVEFEKVKPVKRVVHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPE7</accession>
    <name>A0AAE0JPE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_563846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686624.1">
        <property type="nucleotide sequence ID" value="XM_062830240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPE7"/>
    <dbReference type="GeneID" id="87867394"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3355246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="610" mass="65606" checksum="0CEF3505CA98F0F5" modified="2024-05-29" version="1" fragment="single">MASYRDFEEEGLVLGQQRASSPSSFSTNESTPLLQSPVPELSYAVIDINPRITYTARGRADTIATSSTDTAVDSNANNAYDADQEQYNSLLEARRKHLKPKIIPLCLGAMFLLELSVALSVPPTNAVEESIICRNLHPDVVSGFANNTASLLLSDNPVCKEEDVQSYLAMLQGWQATFDCIPSILMTVPFGILSDKWGRRPVLALAMSGAMLQMFALATIRSIGLKKQTSSSNSSQQTRIGGGGGIIAAMLYTFISDIVPIAERATLFFQMHATYLTARMISGPIAGSLMVKSPWIPLLLSLGLITLAAATSLVFPETQHLKAQASSTKRIDNDDNVPTRFPTDDEEIDKPMIPSSSPSPPSPLSQPQQQPITITTLIQRLTTSLLSFSHFLTINKKICILTLALGLVVIGKYAQALLLQYATKRFHYSWSEASYLLTIPHFTSLITLLVILPFVSSLLLGTSARTTRFRRLTPLRKDLHLARASSLLLTSGCLLIALASTRLSLTAGMILFALGSGLGSTLRSLLNALVDEEHMGLVNSVVGWLEMVGIMVAGPVLAEGMSEGLRRGGGWVGLPFWMAGGLLAGASGLVWVVRVGDGKGDGKGDGRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPH3</accession>
    <name>A0AAE0JPH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_451499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686679.1">
        <property type="nucleotide sequence ID" value="XM_062826056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPH3"/>
    <dbReference type="GeneID" id="87863210"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="349" mass="38867" checksum="C87D2049923D8423" modified="2024-05-29" version="1">MGPPQDHSYKRRRIDADETPSSGRQPSSLSAASAKPARFKPTAARDWTISVAVPTSVITDCVTREQRTTWAGRIARACAVFSVDEIVIYDDSPVESRPASTDHEGYTGDVDPAHFLEHLLNYLETPPFMRKLLFPMHPNLRSQGLLPNLDMPHHPYKGEWMPYREGLTLEAQPKGGKGTVVDIGLEDTVTIDEELPPKTRVTLKMPVGEYGSPEPVHPAVPRTEGGYFWGYTVRKAATLSDVFTQSPYEEGYDLSIGTSERGQSLHRAFPEHKEANFTHLIVAFGGPRGLEYAAMNDPELSKIGIHGPRTKELFEHWVNVLPNQGSRGIRTDEAMLIALTGLRRLWDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPJ0</accession>
    <name>A0AAE0JPJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_36407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686488.1">
        <property type="nucleotide sequence ID" value="XM_062823680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPJ0"/>
    <dbReference type="GeneID" id="87860834"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="119" mass="12908" checksum="74B56C45FAF3FABB" modified="2024-05-29" version="1">MMVSMAADSSMAVGWHVIDTLNDPPGGVSTANIPRPKVSSEPMRGGHSTSKEQRHHLHRFQSPTVVLGKAGEALWTPGARAISPGSPLSRHELSKVRRQSSPCVEFLLIWFSCLLPLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPJ8</accession>
    <name>A0AAE0JPJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_44857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686725.1">
        <property type="nucleotide sequence ID" value="XM_062825907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPJ8"/>
    <dbReference type="GeneID" id="87863061"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="178"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="327"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="475" mass="53371" checksum="51088C2ACE6B8C2A" modified="2024-05-29" version="1">MDFNSSLPHPAGVISFLDTDLYKLTMQCAVLKYFKDVPVTYSFTNRTPEKKLSREAFVWLEEQVMKLGNISLSPEELQYLKTHCPYLTEEYLEYLSEFRLRPREQVAVSFRPTDDSNLGDIHYDIKGTWAETILYEIPLLALTSEAYFKFMDTDWEYEGQEEKAFEKGMRLLEAGCVFSEFGTRRRRDYHTQALVFRGLTKAAKEAEKRGLTGKLSGTSNVHLAMRFNIPPVGTVAHEWFMGNAAILGDYTSATEEALSRWVGCYGPGVLGIALTDTFGTPEFLRAFSKPISASGEPVPQPKHRKVSMADTFISAAKEIIKDLHPGKTYAEVFTGVRQDSGDPKEFVKVMRKFYDEQGIKDKKVIVFSDSLDIDRCLEYKQVAEEAGFQPTFGVGTFFTNDFVHKSTGKKSTPLNIVIKLSSAAGNPAVKISDNAGKNTGDKATVEKVKRELGYIEKDWSEGDESARWGHEGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ47</accession>
    <name>A0AAE0JQ47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_450330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686362.1">
        <property type="nucleotide sequence ID" value="XM_062825996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ47"/>
    <dbReference type="GeneID" id="87863150"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="182" mass="19709" checksum="058826368A596DEA" modified="2024-05-29" version="1">MCLESTETTISTGQCRPVCSHMQRQSVSRDLIRDITSSALGGENRPVTYRGARCVAANGSSKQSQWTPQNTIDPYPHTSSHSPSTPNRSDGKIDQDRPEAGETSLSIGVGTTTNASNGRALKETKTEWDALAKSTVRALICQRCALCVMTSFLDPIIVQAPNRPGPRDNERYVGRGNCDVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJM6</accession>
    <name>A0AAE0MJM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_446899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676791.1">
        <property type="nucleotide sequence ID" value="XM_062825828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJM6"/>
    <dbReference type="GeneID" id="87862982"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="154" mass="16476" checksum="7EE563BCC2F7ADC3" modified="2024-05-29" version="1">MSVTPEDLLPSKGPLSPSRGLLSNHQFGQSDWEESVGVELEESFFRNDLGFADKPVLPERPLSPGVDLEEDFPDQSNYLTGPNGYYGQFPSASTEAQQIQPPQTAAVVEPPQEAVVVEPPQAAAVVEAPQTATNSTAPQGPSIKRSQESNRMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MK24</accession>
    <name>A0AAE0MK24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Succinate/fumarate mitochondrial transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_76833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676744.1">
        <property type="nucleotide sequence ID" value="XM_062831387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MK24"/>
    <dbReference type="GeneID" id="87868541"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="219"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3334578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="327" mass="35477" checksum="5DB6260EEAB9D703" modified="2024-05-29" version="1">MATKVNQDPKKRTSAATNLIAGGGAGMMEALVCHPLDTIKVRMQLSKRGRVPGQAKRGFIRTGVEIVKKETALGLYKGLGAVLTGIVPKMAIRFTSFEWYKQLLADKQTGIVSGQATFFAGLAAGVTEAVAVVTPMEVIKIRLQAQHHSMADPLDVPKYRNAGHALFTVVKEEGFGALYRGVSLTALRQGSNQAVNFTAYSYFKKWLYEFQPEYVGQNLPSYQTTLIGLVSGAMGPLSNAPIDTIKTRLQKSVAQPGESAIQRITKIAGEMFKQEGFHAFYKGITPRIMRVAPGQAVTFTVYEYLKQKIERTGPAALTGGSTAEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNE6</accession>
    <name>A0AAE0MNE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_502606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677961.1">
        <property type="nucleotide sequence ID" value="XM_062827857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNE6"/>
    <dbReference type="GeneID" id="87865011"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052969">
        <property type="entry name" value="Thr-specific_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763:SF4">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="112"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="9">
        <location>
            <begin position="425"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="89746" checksum="172393A435937AD4" modified="2024-05-29" version="1">MATKSSRPPPTTIYRTRTTRAEIKSAADLMLHNAVAQAAAPSPAPALAPGTTFSTASTVISSPNDLPDPFKPFSRSDASTLLQELNIDERKASAAAPRRSTAGMFQAVVSTDLLFLIDTTRSMGSYIEAAKQQVRSIVDEIGKTFFNEAEIRMAVVSYKDHEFNPNIQFLDFTTSVDQVHSFLAGLSIAPRYGDRPEDVLGGIQQAVNASWKNPTRCIIHIGDAPSHGRNLHDMGDRADRFPTPGTEPHRLTYGPLLSQMISKRINYVFLRINNTTDRMVFTFSNEYAATLADTTLLKTNKYYSTLSTNIKRNPSGALLFREVELGITLSALHRLVVNAVTASATRTATRTASRIRKPGNDSSPGSKLPGVGEEEEDDEDDQEDANDPSALPTEIVSPQWEESDWFEETLRMQGFSLNVKHGANTLNEMMERDSNDGLSVLLLTVHKRRLPFAKGILRMASYARTVSSTNPYVAKSFIKKAPQIAYLVEDMRCQALCKAFALEFNALLADSPRHSIDFIVTACFKGKSELKSGDELISIEPYIGLDYVKYNTNAGWVNDSKDLSNEAAQAFSHFTFERSRGAFLVSDLQGVNGLLTDPAIHTRDEDRFPLSKANLGDDGFKFFFATHECNDICRKLGLKSNRLMIVSGNYDFRSDWPSLPDTLCCSNKLCGKILRRADTRVSDKYPEYQWCEMCFPQLESTTEMEVCRADAPYHKFELSRFFHESQGQKVPRMCPEHDNEQNMFGMFMAMPATPELLGGWAGAGAGTGGDFSMFSSMAAPAKPAASKFTQADASLVALWGKLKSATVNLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPH0</accession>
    <name>A0AAE0MPH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_472983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679547.1">
        <property type="nucleotide sequence ID" value="XM_062827170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPH0"/>
    <dbReference type="GeneID" id="87864324"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="770" mass="83484" checksum="36ACA5EAAF9FF8B2" modified="2024-05-29" version="1">MQLKREGTTQSAHPVFASVNLTFSTFNSTRQSSLSIRSLVHTTPSHSFSASCSCVFCHHHFVQQHRIRVHSADINEFAAREIRFVRLATVMATASSSRQTPATWNWSATTLKTTRSRPHLLVLLTLLIIPSFLSAGTASAQCGADFGFPTEKLRVFSLDTINVTYTSTFNKPSLACWCGTSTEKEKKFTVDHATPGNGTTSFPLSFSSTYPCWFELQADSGDCRAESPKFFIFAKDRDPDSRPPATIGPSATIIATQSAIGTATEQPNLGTLPPFADVSSTASPGPPQHPDDHFALGARIALGVGITLACIGVGAMAGFLYFRRRKKQQQAELANAIAEHEYRQGRRGPEKKIFGGFSSSSKTSSDDPLYDTVQPVFDGYPGSTGYDDVRSNGSSDVYGHSPVMPHSPSWSYNQGFLGHDAATGAARERSTERGGLGVGLGVTENLSITGRELEAARAKTVQPIPTSYGPNPVTPTPTLTPRASSRGDLNARAAADSISLDSRLGVPPMPPMPQLPAASAAPLGGYYPDYNNYEQYTIPPPTEAPTPTPVLPLIPVPTTFPHPNPTTSQSQRPGPPLIVSYGPNRVTPTPAVFSPTVPPDESMIEKPPRGVELQAEPASPIERRHPWEDIDLPSASNNGPLPPYASTEEYAAMESGAIRKLEEPRAHAELPPTKDGYYHSTYDIVEHELPGNGYQRDPLYLQGGPSASGRGRDIDEQKFLLDDVEMAHLKAQKERIRAEMKKKQKQKETYQHDQGQDQDLPVASASFSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPZ2</accession>
    <name>A0AAE0MPZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_475847</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678605.1">
        <property type="nucleotide sequence ID" value="XM_062827333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPZ2"/>
    <dbReference type="GeneID" id="87864487"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="130"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="347"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="613"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="832"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="662"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="862"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3339245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="932" mass="103542" checksum="AF74F4473EA87B98" modified="2024-05-29" version="1">MPRRAASPTPSENEVDIAGALFNDDSDFEDNSSKHHTKKGAVTNSGLELDFNDLLGNGDDGLPSFNGEGDDDEAFIASLTRSSQRKSSNIQGKSVKKGGGFQAMGLNAHLLRAITRKGFSVPTPIQRKAIPLVLERKDVVGMARTGSGKTAAFVIPMIERLKGHSPRVGARALIMSPSRELALQTLKVVKELGRGTDLKTVLLVGGDSLEEQFGMMASNPDIIIATPGRFLHLKVEMNLSLASIKYVVFDEADRLFEMGFATELSEILHALPPSRQTLLFSATLPSSLVEFARAGLQEPSLVRLDAETKVSPDLESAFFAVKGGEKEGALLHILHDVIKIPLGPPEGTKEESDELQSRKRKREYRPNPKEKPTEYSTIVFTATKHHVEYIVNLLKLAGFAVSYVYGSLDQTARLIQVDNFRRGRTHILVVTDVAARGIDMPALANVINYDFPSQPKIFVHRVGRTARAGQRGWAYGLVRQSDLPYLLDLQLFLGRKLIIGHDQKNPSFAADVVVGTLKRDGVDVSIEWVEKTLKESADLNALKGVAAKAEKLYMKTRNSASSQSAKRAREVAQSRGWTQLHPLFGEEAAEAQAARDDLLSRINRFKPQETIFELGPKGKSSRNKAAEVVRNMRSRFKERKTTNDEDDEDVDMEDAEGKPDGEETNAFEDFEDEEEAEEAEDKEEDKEDPYADDSDSEMEVTVSSSMHTKKKGGPVNFQDPEIFMSYTPRTTSLAEEKAYGVHSGGYSGNSFVEAARDVTMDLTNDESAKNFGVPTKSKMRWDKRHSKYVAVANDEDGSKGAKMIRGESGVKIAASFKSGRFDRWRKDNRLGKLPTIGETEKSQLIRNFGGQPGQPRYKHKMEKAPKDADKFRDDYHVRKKRVAEAKEKRIGKYKDGEGSKRELKTATDIRKARAVAEKKREKNARPAKRQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPZ8</accession>
    <name>A0AAE0MPZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_578520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679626.1">
        <property type="nucleotide sequence ID" value="XM_062830731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPZ8"/>
    <dbReference type="GeneID" id="87867885"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="263"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3340684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="425" mass="46147" checksum="92A903480558A851" modified="2024-05-29" version="1">MPSPALPILPYLSSSGGTTSALARKFGPETANYFSGSPLNRLSWLRSDHLFLRAAFSHHSAKFVLLNSLGPMVESKEDGSRLGFAGPEDVRGLLGGAEEVFKSEEEVVGGFDSERAAGERVVVFLGVDLLDAAPGEEKDVFEWKQFRGQPYFAVDVTPREGDAGPEGKKAKAEELIRKMEEEKGHAFLSASPRGMALEAGHAAMYAQARSLIDWNARNPFCAQCGQRTVSVHSGTKRVCPPTDKSKDRAPCATRGTLSNLSFPRTDPTVIMAIVSADGTKVLLGRNRRWPQYWYSTLAGFQEQGESIEEAVRREVWEESGVTVGRVVLHSSQPWPFPASLMIGAIGQALPGDGEKIFLGHDAELEDAKWFPLEEAKEALLTGASALGDPAPEGYVEGALRLPPQTAIANRLINAVVEGWWTMPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ07</accession>
    <name>A0AAE0MQ07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_467792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680072.1">
        <property type="nucleotide sequence ID" value="XM_062826923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ07"/>
    <dbReference type="GeneID" id="87864077"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08621">
        <property type="entry name" value="PI-PLCXDc_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041908730" evidence="1">
        <location>
            <begin position="21"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="589" mass="63639" checksum="179BAD162633659F" modified="2024-05-29" version="1">MIIFKTLVTALALTTSNVQAAPLFDSVTTFLTHLTNPPSAQHLDISTPGSDPTGLNTLSTLSSSAKAALQKNQAYLLLINATPFTLRKTGGHSYQMPVWDNSFPDVVQPGSSVRVKIEAKTHKDDAAEMSYVVDELKSEGGGGEVEFQYRGRDGPVLQVEWKSLAAMNNPVGSVRRLDWHQGNNMPFVLSAAPSAMSQVSGGSGANAKFDPAQELMASPGLPTGWMKQAYGRMHCLKLREISLPGTHNSGMSLLTGGTPLVKARPESVQCHSSQMTVGKQLEAGARWFDVRPVIAGGKWATGHYTFFDGIKLPSGLDKVPGLGDLAKEIGKLGGGDKEKVLDGWQGGNGQLVADIVREVNEFTEKNPGELVVINLSHGLNTDTFSGNPKAHLTQQEWENLMTQLLAVKNRATHITTPNTDLTYLKLSDLLPPSDPSKPNDASRAATVLFVVDDITSDNKHVDLSKFANQGFFFRGQLAIFDSYANTNNLNNMITDQFSKLQTHRTKADDAMFLLSWTLTQPVETMITGSIVKYGVDANRALGEKLWAQGEMNGQRYPNVVSVDAFDGDGEVAGLVAGINWWLAGECPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ74</accession>
    <name>A0AAE0MQ74_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_276525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679881.1">
        <property type="nucleotide sequence ID" value="XM_062822817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ74"/>
    <dbReference type="GeneID" id="87859971"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="115"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="510"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3340939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="578" mass="64591" checksum="C97D8FEEBD67412B" modified="2024-05-29" version="1">MASTSRALGRLSAPSMGVARLQTQAVSRLLSSAPRRALISESRQVAVTQQIRCAHTETTPALPEPPKERRRFRTLRWLWKAPLLASLAGIAYVGWGVYEERNPGPQVEPDPSKKTLVVLGTGWGSVSLLKKLDTEHYNVIVISPRNYFLFTPLLPSCTTGLIEHRSIMEPIRTILRHTKANVKFYEAEASSVDPERKVVRVLDTSEIRGDVIETEIPYDMLVVGVGAENATFGIPGVREHTCFLKEIGDAQRIRKKIMDCVETAAFKGQSQEEIDRLLHMVVVGGGPTGVEFAGELQDFFEEDIKKLIPDIADRFRVTLIEALPNVLPSFSKQLIEYTESTFKEEKIDIMTKTMVKKVTEKTVEAEINKPDGTREKITLPYGLLVWATGNAVRPVVKDLMDRIPAQKDSRRGLAVNEYLVVQGTRDIWAVGDCAVAGYAPTAQVAAQEGNFLAGLFNNMARTEVLEQRVRELSGSLNLEPGNAADISKEIEEHERQLRRIKDIKPFHYSHQGSLAYIGSEKAVADVSWFNGNFASGGSLTFLFWRSAYLSMCFSTRNRLLVINDWVKSKLFGRDVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ77</accession>
    <name>A0AAE0MQ77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_542187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678830.1">
        <property type="nucleotide sequence ID" value="XM_062829201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ77"/>
    <dbReference type="GeneID" id="87866355"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF1">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="166"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3339470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="331" mass="36284" checksum="616CE1FA66AB66F5" modified="2024-05-29" version="1">MASPKYNSRDSNIPQIPPQSPESEAFGVESIIYKSDRPSNIPIPTTNAGVNTNHGNRAPSNPNRPPSRPFSTSTAPHMNNTGNTSTFVANKNGQQPSASSPPSPISTPFRTSIHPKLRFLTPSEWARIAHSIGGIADPSCESNTVVHPTCWYWPPRGMPEGLYRDVIYQRTRYMYSYHIFSIMRWFLMILQIVLGAVLTALGAWGGSEGVGTGTPITILAAINTTVAGLLALMHNSGLPDRLRMNKIEFEQVADHLKELLDTGIVEVGQGVDDVLKNCFSRFHTAKATVWANMPDAYTSSSAASRDKPQLICPDPTIHLLVKHEQEAAERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQN8</accession>
    <name>A0AAE0MQN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_444979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679999.1">
        <property type="nucleotide sequence ID" value="XM_062825710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQN8"/>
    <dbReference type="GeneID" id="87862864"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3341057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="208" mass="23474" checksum="E2A62F0EC78C7EB4" modified="2024-05-29" version="1">MNLPRSQSSDFNPSTARLMLATDAPLFATHHFQQCLDVRNTDAMRMNALFIGSNFSSAFSSCRRTYFKSDTFQDHVPDKPKIMDCSDAATSARCRPDSLLRDALVPNFRPVMQINNCPVQSRRGRFTADLTDRDPWRAHRRGASQRTQHRGTWNPSGLTKAVDTAMCMTSKRIDVMPFQKHGGVGIIVSMWFTDIDETLQDNSQPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQP1</accession>
    <name>A0AAE0MQP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_256241</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679295.1">
        <property type="nucleotide sequence ID" value="XM_062822558.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859712"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04461">
        <property type="entry name" value="S1_Rrp5_repeat_hs8_sc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05706">
        <property type="entry name" value="S1_Rrp5_repeat_sc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000467">
        <property type="entry name" value="Putative rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000266">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000278">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000279">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="157"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="463"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="555"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="649"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="737"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="833"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="935"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1130"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1224"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1311"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1383"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1754"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1388"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1428"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1754"/>
            <end position="1766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3340353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1797" mass="196064" checksum="FCCB054F6B703087" modified="2024-05-29" version="1">MGAQKRKEGPGGAPVNKSTQPASESRPSKRPKSNDAGNKAGAKTGKQGNKPVPKSDKPAPPAPSAPANSTLLKEEEPMFPRGGASVLTPLEYKQIQVQAKSDALFEEQSAKAATKKTEKEGKQKKSKKRSKGDDTPAKPDEDAVKVESLNFKRLVKGSLVLGSVCAINPLDIAVALPNNIIGHVPITAISAPLTKRLEASAGNDDAEESDDENDNDVDLESIFQIGQYVRAYVVSTVDEASTHTPGKAKRHIELSLQPSLANTGMAEQDVVVNSTVMAAIASVEDHGYVMDIEIADSKLQGFLARKQVDKSIPQEALQPGAVLLCIVTKNAKGKVVQLSTLGETIGNVENVPSAATTIDTFLPGTAADVLVSEVSNHGIVGKIMGSLDVTADLVHSGAGPDGVDLEDTYKIGDRLKARVICNFPTAKNPKLGISVLKHVTSLKPKTASKDDQPVVPLQALPHSTIVEKCTVKQVEPEIGLYVDVGVEGVSGFVHISRVKDGKVDALFENSGPYKVGSVHAGRVVGYNAFDGMYLISLEKTVLEQPFLRIEDIPVGAVVSGVVEKMVVNAAGVGGLIVKIADGISGLVPEMHFADVHLQNPEKKFREGLKVKARVLSTDAASRQIRLTLKKTLVNSDLPAIQSYEQIAVGQQALGTIINVLQHGAIVQFYGRLRGFLPVSEMSEAYIHDPKEHFRVGQTVSIYVISFDPDAAKLIVSCKDPSAFGLEKQLALKKLQIGDVVSAKVTQKTDDDVFVELADSSLKAILPVAHLTDKSVSKTQSALKKIHVNQTLAELVILEKNEARRSIILSQKPSLVKASKEGKFLTTLDGARVGDEVSGYVRNITATAVFVQFGGKLTALLPKSMIPKEDQDKPDFGMFKSQSITVKITSVNNELNRLVVAIPGAAEQVKKVETKGEKLANPVDESITSLDDISIGKLTKARIVSVKDTQVNVQLADNIQGRIDVSQVYDNWEQIKDTKQPLKKFQPKQVVPVRVLGVHDARNHRFLPISHRSSHSVLELSAKPSDVKEGAASEPLSFDNLKVGSSYVGFVNNVGQGHLWVNLSPTVRGRVNAMEASDDVSLLTNLAKNFPIGSALRVRVVSLDAESKRLDLSARSPGSEDELTWDKIAQDVILVGKVTKIDERQVIVKLSESLAGPVHKVDLADDYEEANPAKFAKNEIVRVAVVEVDKSNKRIRLSTRPSRILNSSLPVKDKEITQNTKLEVGEIVRGFVKNVSDKGLFVTLGGNVTAFVQIKNLSDAYLKYWKEQFQVDQLVKGRIISVANGRIEISLKPSVVDKDYVPLTTISDLKEGQTITGRVRKVEEFGAFIDIDGSANLSGLCHRSEMSDKSVKDARKLYEEGDKVKAKVLKVDVTAKRINLGLKPSYFGEQDDEDEMDVDEEAAEDSEDNDSDEEMSDADGAVQITGTDNVEDDSEDEDEASDVEMADADVKGLEAGGFDWSASLDADEKADASAADLEALAKKKKARREPQITVDKTASLDVNGPQTASDYERLLLGQPDSSQLWIAYMAFQMQVSDLATARQVAERAIKTINIKEEIEKLNVWIAYLNLEVAYGNEETVDEVFKRACTYNDKQEVYERLATIYIQSGKRKEADDLFEKIVKEFGYKSPEVWVNYAHFLHTTAHSPDRARALLKRATQVLGKETHLYLALLPKFAALEFRSPNGDKEQGRTLFENLLATYPKKFDLWNQFIDLETSAADADKGVVRDLFDRGSKAKGLKPRQAKAWFKRWAQWEEKNGDKKSRERVSAKAQEWARTAAERKKTAAASAAQEEESEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQY3</accession>
    <name>A0AAE0MQY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_470752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681018.1">
        <property type="nucleotide sequence ID" value="XM_062827054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQY3"/>
    <dbReference type="GeneID" id="87864208"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="257" mass="29568" checksum="1496CA102764CE37" modified="2024-05-29" version="1" fragment="single">MAPPAAPKMEEIPQADSFSKYLAEGAQDLPRSSDLFESRHAWSYRVRDELEDELERECRDANKHRSDRSKKSHPSAGVEDEHQEPKIVYGQRRKREDDSEEEEAAAERFTKRRNVNVDPEKRPSQPLSTSYQSHALPQANPQAATQAPTQTTARPVHPHKFALTDNGPWYQAIYNEVYKKVYSEIYDEAYSKAYNLAYNDAFKDGYEHGNADGCHDGNNRGFEDGYRHGYKESYRICYGEGQENARDMMSSDDDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRB5</accession>
    <name>A0AAE0MRB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Neutral protease 2</fullName>
            <ecNumber evidence="13">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_244427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="13"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681051.1">
        <property type="nucleotide sequence ID" value="XM_062822365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRB5"/>
    <dbReference type="GeneID" id="87859519"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF2">
        <property type="entry name" value="NEUTRAL PROTEASE 2 HOMOLOG SNOG_02177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041777066" description="Neutral protease 2" evidence="13">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3343258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="351" mass="36581" checksum="B5D3EF79F00D98A8" modified="2024-05-29" version="1">MKFLAGLSLIASVASAMSVDLTQRGGPLDVKIEVVGNTNVKASITNTGKDPLKVLKTGSILDTAAVEKTQIFSSSGPVAFDGLRFRVATSDLPEDAFQLIAPGETVSTSWDPAEVHDLSQGGSYDVKVSGALQYADPDSTELKGTIPFSSNIVTASVDGAAASQARRSFHEKRSAVQSDCTGTKGTATRTAMTNCRALALAASQVAASGSASKMTEYFKSSSSSTRSTVAGVFARVASECGSTTSGYAKYYCSDVYGACSSGVLAYTLPSSSFMVNCPLYFSALSALSRTCHAQDQATTTLHETTHLSQIKGTTDQNGCYGYSCVKSLSASQNLNHADTYALFANSIYVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRC3</accession>
    <name>A0AAE0MRC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_187513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681468.1">
        <property type="nucleotide sequence ID" value="XM_062821595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRC3"/>
    <dbReference type="GeneID" id="87858749"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="79"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3344855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="468" mass="52615" checksum="30C20EB38B8FA0BE" modified="2024-05-29" version="1">MSGLLLPVIRRPSSLISTGSVVRNLKSPQQLVQSQSHHLHYSSRLMSAKLKPAARVAGNRQDVWTIVNEAAAASPRQPIVNMGQGFFGYNPPEFILNAAKKALDRVECNQYSPTRGRPRLRKALSKAYAPHWGRELDPETEITITTGANEGMLSAFMAFIEPGDEVIVFEPFFDQYISNIEMPGGKIVYVPMHPPKDGHIKTLSASEWTIDFDELERAVSPRTKMLVINTPHNPVGKVFSRAELERIADLCVKNQIIILSDEVYDRLFYTPFTRMATLSPEVEKITLTVGSAGKNFYATGWRVGWLMGPADLIQYVAAAHTRICYSSVSPLQEACAIGFEEADQQGFWTQCIDDMQSKMSRFNAIWDELGLPYSIPEGGYFVMANLNKVEIPEGYPFPPHVAERPRDFKLAYFLIQELGVAAIPPSEFYTEANAHIVEDWLRFAVCKPDEVLEDAKERLRGLKKFIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRP7</accession>
    <name>A0AAE0MRP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_425885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681812.1">
        <property type="nucleotide sequence ID" value="XM_062824602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRP7"/>
    <dbReference type="GeneID" id="87861756"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="4">
        <location>
            <begin position="451"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="3">
        <location>
            <begin position="729"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="938"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3345199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1053" mass="122478" checksum="7DCC04F93F18CDDD" modified="2024-05-29" version="1">MPVFDNHEYLTEEEKRLKEDRNRTKYWKKWGPYVAERQWATGKSSHALREDYSADGDAWSHFPHEHARSRTYRWGEDGIAGVCDTHGFQNIAFSFWNEKDAFLKERLFGLSNPQGNHGESIKEAHFHVDNTPHSYMKYLYKYPQAEFPYEDLIKENARRGRTDKEYQILDTGVFEDNRYWDIFIETAKEDDDPDELLFRVTAWNRGPDPAPLHIIPQMWFRNTWAWGREPESNKPSLQAVGENLVKSQHHKLGERYLLLSPSPGVGPSGEDVHPKLIFTENDTNTELLYKVPNEQPYVKDAFHRHIVDGEKEAVNPAQTGTKSAAWFTFNEDGGVAPGECAVVRFRLSKKNTDYLDEEEFDDLMDKKKEEADDFYYRISPLPMADDLRNIQRQAFAGMMWCKQHYLFIWDEWANGDPAQPPPPPERKNIRNQTWKHLHCDDILSMPDSWEYPFFAAWDTSFHCITLAMIDPEFAKKQLDLFTREWYCHPNGQLPAYEWNFSDVNPPVHAWATFRVFKIERKLYGRQDLDFLERVFQKLLINFTWWVNRKDVDGKNVFEGGFLGLDNIGLFNRSEPLPTGGTLEQADSTGWMAFYCLNMLNMALELAKHRRIYEDIASKFFEHFILISDAMTFRMGQKDEKSLWNDEDGFYYDAISWGGPWIQQLPVRSLVGLIPLYATLTLEPELINRLPSFKKRVEWFMQNREDVAERTMFSIRKRGKGNRILLSLVNEERLTKILQRMLDEDEFLSEHGIRSLSKYHKEHPFSMDVNGQTFKVGYVPGDSDTGLFGGNSNWRGPIWLCVNFLLVESLQRFYLFFGQSLQVECPVGSGEYMHLGHVAEEIQHRLQHLFARDDNGRRSINGGNDVLDFDENWRDYLWFYEFFDGDSGRGLGATHQCGWTGLIARMIHDTGVSCRLPHTPRTPRIGMAHYFDDIFHRHAGGAQTPKTPRSPHHLRRNSTTRSIAARSDFEFNGMDDDKELTDDEAASPEDRRRSVSNSVVGLSNGSAREREETDQRLQNYISSQLERLKQERSEGEADGYVVPGGEEFEASATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRW5</accession>
    <name>A0AAE0MRW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_193097</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681651.1">
        <property type="nucleotide sequence ID" value="XM_062821677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRW5"/>
    <dbReference type="GeneID" id="87858831"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="19">
        <location>
            <begin position="47"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3345038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="669" mass="72491" checksum="799585A246F26437" modified="2024-05-29" version="1">MPSATTASTNGANGASASPAPAPSANDNIRRFAAPSRPLSPLPAHALFNEKTRCFVYGLQPRAVQGMLDFDFICKRSTPSVAGIIYTFGGQFVSKMYWGTSETLLPVYQEVPKAVAKHPDVDVVVNFASSRSVYSSTMELMEYPQIKTIAIIAEGVPERRAREIAYVAKQKGITIIGPATVGGIKPGCFKIGNTGGMMDNIVASKLYRKGSVGYVSKSGGMSNELNNIISQTTDGVYEGVAIGGDRYPGTTFIDHLLRYQADPACKILVLLGEVGGVEEYKVIDAVKQGIITKPIVAWAIGTCASMFKTEVQFGHAGAFANSQLETAATKNKSMREAGFYVPDTFEDMPALLKQVYDKLVADGTIVPAPEPVVPKIPIDYSWAQELGLIRKPAAFISTISDDRGQELLYAGMPISDVFREEIGIGGVMSLLWFRRRLPDYAAKFLEMVLMLTADHGPAVSGAMNTIITTRAGKDLISSLVAGLLTIGSRFGGALDGAAEEFTKAFDKGLSPREFVDTMRKQNKLIPGIGHRVKSRNNPDLRVELVKEYVKAKFPSTKLLDYALAVESVTTSKKDNLILNVDGCIAVCFVDLLRNCGAFSPEEAEDYLSMGVLNGLFVLGRSIGLIAHYLDQKRLRTGLYRHPWDDITYLLPSLQQPGPPGTEGRVEVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSL0</accession>
    <name>A0AAE0MSL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UBA/TS-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_426860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682356.1">
        <property type="nucleotide sequence ID" value="XM_062824656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861810"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="151"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="302"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="335"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="12">
        <location>
            <begin position="1257"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="374"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="797"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="924"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="956"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1215"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1228"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3345743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1298" mass="135841" checksum="641B95431B8C8963" modified="2024-05-29" version="1">MASDPDAGVPNLNLTPEEKRVYGQLFRAADTDAVGVITGEVAVKFFERTKLDSRVLGEIWQIADKENRGFLTPAGFGVVLRLIGHAQAGREPSPELALSQGPIPRFDGFTPTPAPAPVPGPAPSPAMPAAMVSPQATGSGPIRIPPLTPEKVSQYSALFERQPLQGNMLPGEQAKQIFEKSGLSNEILGRIWMLADTEQRGALVLTEFVIAMHLLTSMKTGALRGLPTILPAALYEAATRRAPVGGIPPPGRSPTTATPPLPPAARHLTGPAQLTQTRTGSPLGRPPLPAQPTGDWLINPADKARFDLLYEELDKQKKGFITGEEAVLFFSQSNLNEDVLAQIWDLADINSAGRLTRDEFAVAMYLIREQRTKPGQVPLPTTLPPNLIPPSMRAPQGRPQTATGGFQPPRPQPPAPKPSALEDLFGLDDPQPPAAAPAPVQVPIATGGSVDPFGNSASPIAPSSPIRPVATGSNFRPFVPSSSFGRGLTTQVTGGSNSSAPAGSVRASPLPPTVEDDLLGDADPEVNNKLSNETTELANLSNQIGSLTKQVQDVQTQRTNTQNDLSQASQQKKNFEQRLTQLRALYEKEAQDVRALETQLNTAKAETKKLQTEFAMIEASYLELQNQHRTVVAGLQADQQENASLKEKIRTVNGEIAQLKPLVEKLKSEARQQKGMVAINKKQLSTVEGEKGKLQNEVEGLNKEKEELARQAELARQASPVQQVTSPALSTASGNNPFFRRTGSADISAAFASRSMSGQSFDDVFGPSLNAPIQSPTPPPAAVSPVPQVAAFKAQNTGTSTGSFGSGSFATPGSTSPTISRQPTITAESAAAPGGAFSPFGEPSGSGSRAPSRHGSQDQTPAAAALPIEPVQTGQSATSNRPMSPASTTSQSKAPAAPVEADPFAVNTDAKAKEDFESAFASFKNSNAKPAAAAETAKAGGFSKFDSEFPPISELERDDESDSESEAGEAKGGFGFDDDFAPASPPVKPPVSAEAGQAEAVAAPAAAEPVASETSSFTTAPVSSPASPAPLEVSNNENNSTSAAAASNADLDDIWGTRSPAPAAAPVPTSTTTVTVPATAQPPATAVPATAQPPAATSQSSKGAFDDLDDEFADLEDAKEGSSADDVEDFANISRSGFGDDGFGSGSQFGSPPPSQSKSDFDFIPSHQATQSQGSFAAPKADAHDWDAIFAGLDEGSQAQQGGQSPFESLETPRPGSSANPQAQTGGEQKEGEGKEQKKEGGEERPAPGRALTESGEHDDPIVKNLTSMGYSRQDAVKALEKYDYNLERAANYLASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSR1</accession>
    <name>A0AAE0MSR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_155559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682862.1">
        <property type="nucleotide sequence ID" value="XM_062821150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSR1"/>
    <dbReference type="GeneID" id="87858304"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="163" mass="18200" checksum="E5C25DEF04C13336" modified="2024-05-29" version="1">MAPTKTLASLASLFIRQDPPTATVTVVQQADDGNGNGGGNDHLSTGAIVGIVIGVIVGLILLWWIFKSLSRDKNSRMAPAPDRQAYDPDMPPAAMYRSRSSRSRSAHRSRSRGHHHHHHRHSSRSRSRPVVYDDKMYVATPVQPAAVYTYPDRRSRSRSRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MST6</accession>
    <name>A0AAE0MST6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_190751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681575.1">
        <property type="nucleotide sequence ID" value="XM_062821634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MST6"/>
    <dbReference type="GeneID" id="87858788"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="212" mass="23788" checksum="799425AA9984F585" modified="2024-05-29" version="1">MPPKANQDIAGQMNFLLTCIKHSTNGKINWTEVAEELSIVSKAAAAKRYERLLKSHDIQPPKNYGSLTDDVGASGASSPVKAKTPRAPRTTKRKRATATVNYNEDSGNENGSADNREPFTYKAEPEDSDDEEKKRPLKKEKTTPDVQTKQEEDEDGESDYFSCFSDDVDLLVVEDIEAEYTRYRCEGKGYDVLMDVVGRIEGEDNYKYEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSV2</accession>
    <name>A0AAE0MSV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_460730</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682626.1">
        <property type="nucleotide sequence ID" value="XM_062826555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSV2"/>
    <dbReference type="GeneID" id="87863709"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000054">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="11">
        <location>
            <begin position="235"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="13">
        <location>
            <begin position="862"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="815"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="908"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="824"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3347544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1064" mass="115238" checksum="3BCE7EA1855DC6E0" modified="2024-05-29" version="1">MASNSWQFAGADDESDDDNFNPAPADMSDEENNENDEEHTHNHRPAGKTVRQASSPVPDEEEEEEEEHDEEEDARPAKRSRRDHHDDDEDEEQDEEENEEIDEEEEEEEEEDEDDEDDVHGGNRRKRRNKDRRAAFFDIEAEVDDEDEGEDEVGDGEEIEDFIDNAHPDDIADSGRLNDDRRHRELDRRREMEASLDAEKQAEILRERYGKRAPARGYGDMAIVPRRLLLPSVEDPSIWAVRCKEGKEREVIFSIMRRIEERMGTKNEVPITAAFERGGVNSVMKGYIYVEAQRQNDILVALDGILNVYPRSNMHLVEIKDMPDLLRVIKTPNLEPGAWVRLKKPAKHAGDLAQVIDVTENGLEARVRFIPRLDYGVRDDPVFQADGKRKRPGVPGPRPPQRLFSEAEARKRHLRHLQGNPQTNSWNYNGDDFENGFQVKDIKIQQLEVKNVNPTLEEVTKFASGAEDGTENLDLKALAATLKDSAKSVAYVPGDIIEVYEGEQQGVIGKATNVQGDIVTLQVTVGDLAGRTIDVPNKGLRKRFRIGDHVKVIGGSRFRDEVGMVVKIVDDRVTLLTDQTNTEITVFSKDLREASDIGGQGSLGQYSLLDLVQLDATTVGCIVKVDRESVVVLDQNGDTKQVQPSQITNKLPKRKFAVAADRDGSEIRLDDVVREHGGQQRQGKIIHIHRSYIFLHTTTTNENAGVFVTRANSVTTVAAKGGRNTATAGPDLSSMNPALKRNPAANGKQMPAPRTFGPDRAINQTVVIRRGGHKGLLGIVKDTTDTHARVELHSRGKIITIPKADLSFKDKTTGKTIDINQRGGSRGGFGGGGRGGGEFGSRTPMASGGSDRTPAWGSSRSTARTPAWNRDAGGSRTPAWNDGSRTVNPYDGSRTPYGGATAYGGIGSRTPAWHSGSRTPAPDGFGHGSKTPAWSAGSDSWGSKTPGYGASAPTPGASGDAWGVNSSSAYDAPTPGGGLSAPTPGAALNAPTPGAYSAPTPAAVSAPTPGAWQGGWGSGGDAVSAPTPGALGAPTPAAYYSAPTPAYGGAAETPGGAPGYADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTD2</accession>
    <name>A0AAE0MTD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_454599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683673.1">
        <property type="nucleotide sequence ID" value="XM_062826202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTD2"/>
    <dbReference type="GeneID" id="87863356"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="89" mass="10259" checksum="86E79B27A5C5EEFF" modified="2024-05-29" version="1">MQRLFPGVCRPVRYVRGPIEVKVKIPDGYRIQLEALEELFNLHNEDPEKQPPYFGNIELERSCPRAALDVWEGPSGLEPKRFITHNGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTP1</accession>
    <name>A0AAE0MTP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT-NTPase sigma domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_455765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684033.1">
        <property type="nucleotide sequence ID" value="XM_062826253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTP1"/>
    <dbReference type="GeneID" id="87863407"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031353">
        <property type="entry name" value="NACHT_sigma"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17106">
        <property type="entry name" value="NACHT_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase sigma" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="61" mass="6746" checksum="1253CD10218227B6" modified="2024-05-29" version="1">MSYHQPSVFRNYGTGTQNIHSGRGNQNINSGQGPRRISYPTQKSSVITCLRSRGYTGMNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTT3</accession>
    <name>A0AAE0MTT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_570286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682550.1">
        <property type="nucleotide sequence ID" value="XM_062830443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTT3"/>
    <dbReference type="GeneID" id="87867597"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="229" mass="25696" checksum="055781F2D7C45024" modified="2024-05-29" version="1">MMVLVSRQYQAPGLRFSELQALMKNGWKPWMGPLSAATPIHPIISNRNSIVNFKTLMRACVNLNAQTHKREANGHPTRRGIEQQSIAGKASSFEGSRPVASQLTFVPCIKNTKDTRTLTPPCIRAQDISNKQKQRTLNTPTPTTTQGTKGNSNPQSPFQYRSSLAKKVLSEVPHSETCAIGRRRHRPAADPPTSRQVPRQSQAKIFYFHFQHLAFWRLGTGPTEKSQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTZ1</accession>
    <name>A0AAE0MTZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_102786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684197.1">
        <property type="nucleotide sequence ID" value="XM_062820459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTZ1"/>
    <dbReference type="GeneID" id="87857613"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="670"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="767" mass="85180" checksum="CE04A28F566BDFD5" modified="2024-05-29" version="1">MSSSPELGHSPQLSSLSSDMIAISAMNGTAIDTSQRPKRARTSKPKVKTGCSNCKLRRIKCDEKRPACSNCVRSRKECTGYPPPPRSARPFEEIRIAPKPLLAAATPLPGRDAPIRLVPRRVVKYQRRLNTPPETPPQESAATAVILHRAPTANVPFTDREGLYFQLFREHTANELSGFFDSGFWSRTVLQECHSEPTIRHAVVALGALYKTLEKTCESPPGSPASDRDPTDLAMTHFRMALEKYHEAIRSLLNTADPMSNRTRLMASVLLACFDSFVGDHKQAIFQIQTGLQLLEKLRAERRRAFITQPGEPVEDELIQMFTRLAIQAKSYDMAFHFPQPYVVRLTPTEQDPSSPASDASSPGSQFQEPIPDRFASVIEARVAWDKLCERIFKFTETMFKHVPNGPMGLLPPNLKRYGLSFKQDLDAWSEAFEPILQSRTAPGVTSQEKAAIAVLKMSQIMALVLFLMTFNASEMQFDNFNSYFKAIVDLALEVVGDEERRAAAKRCPDPDFCRHGHGHNNSYALARDIFGGHEYAARHIKPSFSADLGIVPPLFVVATKCRDPVIRRQAIQLLRSSARREAMWDSELTARIGMWITEIEESDDFSMIVTPGSSPVASYSQMSMSMSMSMGMGMGAMDEAAVVVENMDGGAAASESGVVRSDSNGSMNGRNSTRWGRRTGSSSSSTSTTTTTAGRSSSTHYIWPTQQQQQQLAPPPPKVIIPEERRVMVRAVQFDLHKRTATVQLGTRGLRNGQMDLKTRTTSITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTZ5</accession>
    <name>A0AAE0MTZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_419231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684212.1">
        <property type="nucleotide sequence ID" value="XM_062824196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTZ5"/>
    <dbReference type="GeneID" id="87861350"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004454">
        <property type="term" value="F:ketohexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01939">
        <property type="entry name" value="Ketohexokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034093">
        <property type="entry name" value="KHK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="4">
        <location>
            <begin position="330"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3350917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="423" mass="45264" checksum="9A2FDBF42F53AD3A" modified="2024-05-29" version="1">MKHLILVGACYLDTILTYHSVLIVCSVPQFPEEDSKLRATALQVRRGGNCPNTVEVLQQLLLSGRGLASSSTQNQQDSAADIVAVTPPPSQQQQQLTLHLVSILPDVGSSATRKILSSFAAPPAPQPSPSYDSESMSESVTGATSATATSVDFSHCLYRKGHDETASSYIIRSGATGSRTIVNYSDLPDMTTDEFVNIVHDFVALQHKHSDDGSLRGFLGEDCWWHFEVLPGSTVSVEVEKPGREGLAELAAESDVVFYSKSWAESRGYTEPEACLRGELSNCKKASLMLCTWGSQGAGALFPSPAGASGGNNEQTAEVADPEYLHCSPSEVSETQTITVVDTIGAGDTFIAGILYGLLMAEPDATAASASTSATATTTTSHDRFWTQSWSQKEKKKQLLAFAVRLATKKVQMEGFAGILKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUH9</accession>
    <name>A0AAE0MUH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_546529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684797.1">
        <property type="nucleotide sequence ID" value="XM_062829449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUH9"/>
    <dbReference type="GeneID" id="87866603"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000030">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="417" mass="45025" checksum="B99036F1C9F1B0E5" modified="2024-05-29" version="1">MPRDPLIGLVGKPSAGKSSTLNSLTDASSKVGGFTTIDPQRAIGYLQIDCACARYGVSERCKPNYGSCVNGKRSVPIELLDVAGLVPGAHEGKGLGNKFLDDLRHADALIHVVDASGTTDAEGKVTRGYDPSVDIAWLRSEIVAWIKGNLWEKWGSIKRRHIAVKATAVETLQAQFSGYGSTAAVVARTLDKLGLKEPLEEWSEETVDRVVNAFTDEKFPTVIALNKIDHPDADKNIAKIAKMQDPNSIVLCSAISEIFLRKMAKQGYIKYTEGSEFVDTREDLIADGDPDGGGLKELDEKNRNRIENLKDMVLYRFGSTGVNQVLSKAAEILGLVPVFPVRNTTTFTSGANESANKAVFRDCVLVKKNSTVADVARKIMGDAPIAYVEGAGGIRVAEDQIVTVGKNDILSFKVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUM7</accession>
    <name>A0AAE0MUM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_391625</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684229.1">
        <property type="nucleotide sequence ID" value="XM_062823749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUM7"/>
    <dbReference type="GeneID" id="87860903"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3350934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="73" mass="8161" checksum="2869B8BB382951C6" modified="2024-05-29" version="1" fragment="single">CYRSGGMCIGSIGSNANQPDYVENVVFENVELHDSSNAAWIKTYPGRGGYVRNVTFRNIHFENVNQPIYVTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV72</accession>
    <name>A0AAE0MV72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LRG1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_1953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685533.1">
        <property type="nucleotide sequence ID" value="XM_062821707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV72"/>
    <dbReference type="GeneID" id="87858861"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09393">
        <property type="entry name" value="LIM3_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04397">
        <property type="entry name" value="RhoGAP_fLRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000112">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="468"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="828"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1174"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1190"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1201"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1245"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1279" mass="138927" checksum="84F69359AA9450D4" modified="2024-05-29" version="1">MASSDYGGGPVGDREFTHGHPQGHPQGEAAHPREDEHLDITQTISQQNGAPTNAHLARIPGSPALSAADATDLESRRSGEKNRPKPKGSRIASGQVRVCKKCGEPLTGQFVRALDGTFHLDCFKCRDCGQIVASKFFPADDNNGEGQYPLCETDYFRRLGLLCYQCGGALRGSYITALDRKYHVDHFTCSLCPTVFGAQDSYYEHDGHVYCHYHYSTQYAQRCSGCQTAILKQFVEIFRNGQNQHWHPECYMIHKFWNVRLNPPQKALGPVPDDPAGRELVRDEEERMEEKVYRIWSVLSTFEESSAACISDMLLHVSNGAYVDGVMVAKKFIWHVDILFHSADRLDATMARLDMTGLMYGREAKLLCKKIVAFFSLLSKTQDKGSRKLGVTQELLTLVTGLAHYLKLLIRICLQGALRIEKERDTADGLDAFLDELNDLEALKTEDNSTTTLQLTSGMARLSASDSDSCTLCKKPIEDECAKSGDKRWHITCVNCSRCQRELGRSLQDARLNLYDSKIFCNNCESYSSDKAPPFERVSKLQQYMFLLQVALARLLEILRMHGALPSAAEARGHNGNDAGDGRPSLDGRQRGFPGGDQSQHHRESSYESALNDVKRLKSTRLDKHLSSSFRKARTSRIMDGPESSSAQPGSGPGSGVDGGPANGRRMRIEEDMGPGDDHDMMLPNQDALTLADIPRIVAAEQAREQRTGPPSRHELLRSPATEPSFGGASSGSGHKRSYSDSKGGDARAAGEPSPQRVGRRYFSELSALEYFIIRHLAVVTMAPMVEGEFTLVELIGLIETRKTPNFWKNIGKAFQKDGRKKKGVFGVPLEAIIERDGAESTDGVGPGTLRIPAVVDDILALMRQMDLSVEGVFRKNGNIKKLGELVEKIDKEGNVDLSGNNVVQVAALLKRYLRELPDPLMTQKLYRLWLAAAKISDEDKKRQCLHLICCLMPKCHRDSMEILFCFLKWAGSFHQVDEESGSKMDVKNLATVIAPNVLFDRTATSTLGSDPMYAIEAVEILIANIEEMCLVPDELVQYISDPAFLDAELTTKEILKRYSERNTGGFGSRQYADVVEIVGRHENPSRPPPRRVESDPTSWQQETSVRTVTENAAYLGPGPVGGGSGNNGGMVDRMGGPGGAVSPQKRGGPGGMGPHPLSQSHGDGGPGGFSNHPPGPPGGPQQPIPYGPAPEHAAAAAAAAGGGPGGPGGPGGPGVGPGGNAIGGGGDGAASGGDYNRNGGPPSGQHNHNGGQQQQGPRKEWRNSGWGRPNNGVTTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVM4</accession>
    <name>A0AAE0MVM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_109379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684470.1">
        <property type="nucleotide sequence ID" value="XM_062820552.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857706"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000016">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000868">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="623"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="866"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1390" mass="153803" checksum="2788F6DFB852FEE1" modified="2024-05-29" version="1">MAKKGTKSSAPAPAAASSSAASQPASKSKKDSKKAAGPSEGDFIVFSNSDKEPKGKRGGAKAGPSKPAEELDAGPPKPTIKQIIGGHSWTGKLPVNLLSEHCQKQKWERPDYNTIKTKDGFSVFVTLSAKNPKTQEVTTLPPFKLPPSHVHLAYKPTALEAKHFAATYALYRVCSMKNMHMTLPPDYRSLWKEFEALKKQDVKEGKAWMYEADPFQALREREEAKAAAEKKRAQLQAAKEKAANEPGVSLAFRGSGSGGGGGGGAHNVMRGWANVPKIEMGNKTRSQLEDLLRRETVWNPNGVVMAAPQKAAIVKEFKDLGFRQSHIEEAVEECKDREEALEWLLVHIPEDDLPRWALPEKYSAGVTVAATDLKREGAITRLAQSGYSIDLCRKLLALHNGDEAKAAEDLQKLLLASGSESVDNSSADADGLDTWRDADECWEEEMATLEACFGEKFSKTSPEVCEIKLEGVKNGTQTNVDACVQFRKSEQYPTQVILAMVAALPSYIKLSVIKQALAYALTLEGEEMKIFYVASWVQENINDIIEKPGRIREVAAVASAASEEPKRVVKRARRTPRYPKPINWTPDARSTEEWRARTETPSYKKMLYARQNLPAWQVQDYLVQTVSENQVTIISGETGSGKSTQSVQFILDDLYSKGLGKSANIIVTQPRRISALGLADRVSDERCSQVGQEVGYSIRGESKTSPNTRITFVTTGVLLRRLQTSGGRVEDVVASLADVSHVVVDEVHERSLDTDFLLAIIRDVLYKRRDLKLILMSATLDAASFKDYFTVDGKNVSVGLVEISGRTYPVQDYYLDDVIHMTGFSIGNNREYYYDDNAGSRSKEDPNDDPINKIIQRMGSRINYDLLVETVCAIDSDLAETQKAGGILIFLPGVAEINRACNALRAVPSLHVLPLHASLETKEQKRVFAAAPPGKRKVVIATNVAETSITIDDIVAVIDSGRVKETSFDPQNNMRKLEETWASRAACKQRRGRAGRVQAGKCYKLFTRNLEMQMAERPDPEIRRVPLEQLCLAVRAMGIKDVSHFLSRAPTPPEATAVEASITMLRRMGALDGEELTALGQQLAMIPADLRCGKLMVYGSIFGCLDDCVTIAAILSTKSPFVSPQEKREEAKEARKRFSQGDGDLLTDLRAFQEWNDQMHERMGQSRVRAWCGDNFLNYQTLSDIASTRSQYYSALKEMGIIPYNYSEYNNQQTKSMALLRALTASAFSPQIARIQFPDKKFAASMTGAVELDPEAKTIKFFSQENGRVFIHPSSTLFDSQGFTGNASFMSYFTKIATSKIFIRDLTPFNAYTLLLFSGAIDLDTQGRGLVVDGWLRLRGWARIGVLVSRLRGLIDKLITMKVENPALDVEKNDIIKTVVKLVELDGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVS9</accession>
    <name>A0AAE0MVS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_417093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686207.1">
        <property type="nucleotide sequence ID" value="XM_062824067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVS9"/>
    <dbReference type="GeneID" id="87861221"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="291"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="679" mass="78009" checksum="0856E2B57C9864CA" modified="2024-05-29" version="1">MSTAGATQSPEAQMRRRCGGYLPIENYGLIGNMRTCALVGMDGSVDFMCWPEFDSPSVFCRLLDKDKGGYFIIHPAAHLGCTTKQQYLPSSNILQTRYIHEDGVVDLVDFFPRPRTTQTVIKGLKTSAYREMTSVQEELKKWLVRRVECIRGKFSLEVEIFPAFEYATAPHTTTILQEENVSFATESKTVTFHSKDVKLQLDVSIDRGEEEYHSYPTVHFKKVKKPGMLGEGVVASIDLLEGQAVSFILRNDIPNHVTEQITNLVLDTQQHGTQTYWYNWISKCKYKGRWREVVQRSFMILKLMTYEPTGAIIAAPTFSIPEDIGGVRNWDYRFSWVRDASFTIYILLRLGFTEEADAYMKFISDQFCRSRVADGGLPIMFTIRGETDIPERELTHLDGYRGSKPVRVGNGAASHQQFDIYGELMDGIYLYNKYGKPIHWDLWCSIREMLDYVLTILSDPDMSIWEVRNNKQHFTYSKIMLWVAFDRGLRLSEKRNFPCPNRAKWLVARDSLYEEIMEKSYNKEMKCFVQSYENQTILDSSILIAPLVFFIAPNDPRFLNTMDRIMLPPDKGGLTSTGLVYRYDTEQSEDGVGGREGAFSMCTFWLVEALTRASVYEPKYLVRAINLFENMLSFSNHLMMFSEEISRSGEQLGNTPQAFSHLALISAAFNLDRVSEFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW72</accession>
    <name>A0AAE0MW72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_15260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685879.1">
        <property type="nucleotide sequence ID" value="XM_062821099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW72"/>
    <dbReference type="GeneID" id="87858253"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="7">
        <location>
            <begin position="166"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="54669" checksum="D4877CD2AA6017FD" modified="2024-05-29" version="1">MKQGDEVAFLPSIVEAAESSPAAAAECARLIRKYLQRDYWSKPSLQYNAIMLIRILADNPGATFTRNMDKKFVDTTKELLRSGKDGNVRQMLMETLDAFESTKGYDENLQLLIEMWKKEKEKAYRVYGHRFSSPPPQQYSPYLSHQQSLPNQQEYFQRTHHTPRLPDPVELANRLEEARTSAKLLEQVVACTPPQEILSNDLIKEFADRCTSASRSIQEYMSATDPAPDNDTMESLIDTNEQLQQSLNHHQRAVLNAKKQLGIGSPGSESVSRPGSVAPGVNEQSRPPPAVAGTSYNSRNEGVQDWLASSSAAAAGGSGSGQGASGAGASSSSRGKGKAVATSSDDNWGLSDYKYEPISASGAAAGPSRSHTGTPYRDEEDPFRDPFQPDSSASSMRRVVQPSTLNTTNVGNNDERLSFEPYHPGFGGGSNNNNNLNSTSAGKSNNDNYSYNSSSAYDYRGNGGGSGSGAGAGAGAGNASNSIPEPVTPVSDDGLYGSGDVHRSTGVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWA4</accession>
    <name>A0AAE0MWA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_42133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686658.1">
        <property type="nucleotide sequence ID" value="XM_062824335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWA4"/>
    <dbReference type="GeneID" id="87861489"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42807" checksum="40300966296DAD00" modified="2024-05-29" version="1">MSSEGDRTGKAGIVVAPEDVGGVDKLAYSVVDDLLYNILHDLVLKVHQDEKTARMRTAAIKVEKLAMENSDLSTPDARPEIVVETDAALYKDGHVTLKGNPLKTTKEILCPRCQLPRLLHPTDGKGAQKPDPNVTYCKRHPYIEKPGFDIYGQTWVQPGPGRGKKKKDMEKKMDPNDPAAVAAMEGSAKDRPPHVLSFPSATCSKCKRCILVTRLNNHMGSCIGNSGRNASRAAAQKISNGGSNGGSQNNDNTPPASQKGTPVPTSRATSPRKRDGDEFDEDGDEADPISAKKKKLKPTALPKKVILKTKSTPPLKKDKIKTSSMLSVEQSVDDDDIKNSTVQVVPKKTTPAKGASPVKKLKIGLGTKPQLNAPGKKLGKKEKDHETGSTGTMSPPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWX3</accession>
    <name>A0AAE0MWX3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_505740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687288.1">
        <property type="nucleotide sequence ID" value="XM_062828009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWX3"/>
    <dbReference type="GeneID" id="87865163"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="254"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="629" mass="69731" checksum="7759268B165AAA12" modified="2024-05-29" version="1">MGSATFQQPSYYRTPPLNVDTSCHGREFFDDDEILDDDILNQSTLNSALEMSPPLTDSRRDSFAVSATTLFSPKSDDSWPPVEMQSVPSNNPFFGQHNNNPFMQMDQNQQSTYQNHWGMMSSGAATPLQSFDGLPQAEYESSTVPLFRPATVQAQTPFSNPNNQAVMFQQLGHHGIPAVPASPPKEHWINQELKNQAMAKRNRPTTPLIRSHNELRRGDGIRKKNARFDIPAERNLSNIDQLIAQSTDEQEIKELKQQKRLLRNRQAALDSRQRKKQHTERLEDEKKHFTEVITNMEEQMNALQREMEQLLREKQSYEAYISELKNEKEEIIREHTIETGDLRKKVNVLTNHVQALESAAMSTPPAGPNVSGFPGAYGEMEGMAMDGSWDNMPIFGEFTMEQQPSEVKQELQIVPTKKSEVSLSTESEKSPSQGGLLFMLFLVGAFVLSNRSPPSIPRVSEDIRVASATLLDNVLKDAGLPQAASGLEAMAPQPSGSSWAQNTGSSLPVAASGMDGVAPSMLGEMADALTQPTEQQTNEQLFGLTAAQYNGISSQDFLQNAPAERSTSKGRRNLAEALASMRAAANKDSAAEVYTRSLLWDKIPRDVVRDFAKMVAESQQVAASNEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX23</accession>
    <name>A0AAE0MX23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_544769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686901.1">
        <property type="nucleotide sequence ID" value="XM_062829324.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87866478"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11148" checksum="C7D775445C5BAFA4" modified="2024-05-29" version="1">MESGPLLSYSPRDSTSEDQERIRRIFWSCYILESDYLAELSNLPLSGIARIESSVPLPGAGYSTHSTAQEEEQSSLETGASLDDKRFPGIVKELDHQLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXB4</accession>
    <name>A0AAE0MXB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_438198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686285.1">
        <property type="nucleotide sequence ID" value="XM_062825356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXB4"/>
    <dbReference type="GeneID" id="87862510"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="709" mass="77944" checksum="EA600C366437B625" modified="2024-05-29" version="1">MDTTTTDPSTNTYSLLCRNFSFLCPCALHRQQRTLPLRSATATPASDDASPTPSSQRTLRRTPRFQGARSPSPTPSPSRSSRRIHLEAASVGIAPQPIFATAGPPGLGQPPQPHESFRQRLSQDSSDDLNEDTFPPQPSFIPERTSSLSHSNPLRLSRHTKSAILWALEEALRQPYSFSSDLDEENASMADLLSGGVGPATSNGHAVPSSRPTVPSQTGSPQQVIRGPRMIMRERAEREARQKAEREQMERARAEEEARMLEETRRQNAERRNAAAGAAPGGNVATDPATQRRQKRAQEAQGGPQVQPGNPPQADAPQSLRPARTGQPNQAPQGFTPAAGTGGTAPGQPAEPSALNAGTRVKNSFPHAFERWEALSAHWEGMTSFWIRKLQENTDEFDRNPISAQLSRQVSDLSAAGANLFHAVVELQRLRASSERKFQRWFFETRSDIERLQETNAMLENALEEERRSRAETARQAQEQERENAKTQKLLAEMRKELLISKDEARRAWEELGRREQEERDRTLSLQQGHPTIVGGVQVVPMTQGVPNRQASTRDHQRTQSDTSDYVAGQNPQYPQYTQGSAAQPNTTAAGQPSGGYYQQQPGTSTQQPGDYGAGSEAGYDEAPRPEEAHQSDQAAEDFETPTSNPATNYPPSSSQYGGTYPESSGYGGQGYAAPGWETMPRHHHPTRLSDVLEEDERSRTSASRVSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXF2</accession>
    <name>A0AAE0MXF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_62494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687276.1">
        <property type="nucleotide sequence ID" value="XM_062831175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXF2"/>
    <dbReference type="GeneID" id="87868329"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042295306" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10258" checksum="C4540595B343FE3F" modified="2024-05-29" version="1">MCSLPLLFYVPFLHLQSLGGVLSPQAHPQYGWVVRSKWYLQSSDMVHWERGCRSKMRNSNIPQQLASFVLCVFRCWADIPLCVVVSLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXN7</accession>
    <name>A0AAE0MXN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_439284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687500.1">
        <property type="nucleotide sequence ID" value="XM_062825403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXN7"/>
    <dbReference type="GeneID" id="87862557"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="193"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="302"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3356123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="713" mass="79746" checksum="B7014241E364F367" modified="2024-05-29" version="1">MLRRLICALLQGSADDNDSFKKPRRSERLSSQRIDDSAEPKQKTPVNTTKQLPSPVTHDTDDYPQDAKEPTATPPAGRPSQLSQISPRPETQYSQSQVLNDTQAFSQLPDIDRPLSDDVEDEVKEGVWGYLFPLDPRHGGRCVVLRRRAACPLPHTVSQAVGSKRGKRGQKALIKEEHELDKTKVKGLPSGGYLIGRHPECGWFTCTIPGVLHHTNGTLDIQIEDPIVSNRHCIIFTENKGNDTVAVLEDLSSNGTFVNEAIVGRNRQRELQELDEIAVLDKARFIFRYPKSRHTSAFRQQYTMLQKLGKGHFAEVYLCVEKSTGSQYAVKVFSKTPGREERSKNEGLQQEIAVLMGVSHPNVLCLKDTFNEPNAVYLVLELAPGGELFNYIVKKTKLSENECRKLFTQLFQGIKYLHDRNIVHRDIKPENILLVDDDLHVKLADFGLAKIIGEESFTTTLCGTPSYVAPEILTDTRHRKYTKAVDVWSLGVVLYICLCGFPPFSDELTSPDFPYSLSDQIRQGKFDYPSPYWDPVDDLALDLIDSMLVVDPEKRFTVDECLSHPWMTEKKPGVNDSTNGLVNGIAGLDVTRRGVLRERTLLSSINTVQIADKIPLGDNKPELKIYKKNPTVAADGPSQHEFVGAQAGPSRQKEARPDDNRDPNEFMNMGGKGDEVLFAEDPKSNYPTAREDAKDIVEAAKTNDKGKGKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXV5</accession>
    <name>A0AAE0MXV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_516386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686855.1">
        <property type="nucleotide sequence ID" value="XM_062828666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXV5"/>
    <dbReference type="GeneID" id="87865820"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="253" mass="29055" checksum="8B4AFB6676F70AA3" modified="2024-05-29" version="1">MDVERGPRSLSRYDAGPGLVFKLSQILSRFLALIYEAGILAVMGWWYHGWKGNPNARVDLIFPCFFPLGVAVIVNAYEIVSFSCLDRRRPINVIAVCFDILICAGSTFCFLLLGLIDNDQVQDRLRTDSTRERWKKDQSKAMIFMIVFCFLHALFVIMASVGCVYSGVMKNRARRQRRIVRNRAQMVRFAEERRRRMEVEKAQVEAPVEDVGQSEERIPERNPRGTESTGSTELEDNERKTRKRFSGGTEVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MY28</accession>
    <name>A0AAE0MY28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nineteen complex-related protein 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_452901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687110.1">
        <property type="nucleotide sequence ID" value="XM_062826127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MY28"/>
    <dbReference type="GeneID" id="87863281"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="578" mass="61412" checksum="412DF8CAA130FBA2" modified="2024-05-29" version="1">MSSFGKRKPRIIQTFDDEDGDLPTLLGGEEPKREQPVPQGPIKFGRSKPVKSSSLRRTIKINDDNDDDAQDTNGDAAKPISTSTSAAPDEAEGDEDTGVPLVVRPGFGRSASSKKKRVSKLSFGASEGDTEDGGNDTTTTASSDVVSAPSKKSLSQRVAEKNALRKSALTARFGTFGADEEKPRYSKEYLEELQTSTPATPQNLASLSIIDDDDDDSLKAHSAPPPEPPAATGATDDAMDLDPSELDGAMIVQSRDLPVARTGDAGPSAAAHILTEAEIRERKERRARLAKEHDFISLDDNSDSDDDDRKRVTLSLNKKSKKSESRLIAEDEDLGEGYDEFVTDGSLALGRKAEREAAKRHRQEMAEMIQAAEAGSDAESDDSEAERRAAYEAAQRRAGMDGLQKPEDDMMEIDEEGGGGVNQIPKMKPLPELGEVLARMRGLVQGLEDEVSRRKARIESLEKEKGEILSRETEVQEILNQAGAKYQAVMGGAGAAGATAAGAGAAGAAATAATSAAAATGATTPGDALKFVTQSPLRPLPPGFAVDLAATPKERGLENFGTPTQEKGPNDMDTEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J056</accession>
    <name>A0AAE0J056_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_73930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676630.1">
        <property type="nucleotide sequence ID" value="XM_062831347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J056"/>
    <dbReference type="GeneID" id="87868501"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042142218" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="46221" checksum="E35C9FE6DEFC01CE" modified="2024-05-29" version="1">MRFHLLAGLIAFGSGLGVHAAGLAVAAVQPSAAVTALPTDARPTDTGPLQPTITNTFLTSSISDTESGSTLTIPWPISPIPSSSFSVITLSPSASATPVSCPRDNNTFWTDHATNNVYQLQCGIDHYDGAANWNFNEGMRHSWEDCAKWCAEYDQCLGFSYIGGIPLQPNCWLKNSLRGQTLNWNSWAGMLVTGGNAVAGHGDGGKSAAANTVAGLVKETTTFLAVAVDTTTMIVEGTAVTTAVTTVVTTELVKPIAPATTLSVARTGSALPNPTAIAVSCNNETWWADERASWRAIEYFCKGGHDGTFGGHASDKMMHGENSIAAAYWPYNGTTVITSVVSKAGCTVTLDKNLCIQRFRAPMYGCDSDERYQKRGGSVSDGCSDWTIHMQSWPSVGLCQDPDQDMASAGLCATWSTGYSSESAAGDGLKIDWFPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0E8</accession>
    <name>A0AAE0J0E8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_77861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676839.1">
        <property type="nucleotide sequence ID" value="XM_062831403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0E8"/>
    <dbReference type="GeneID" id="87868557"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF11">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN_GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041988004" evidence="3">
        <location>
            <begin position="35"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="324" mass="34578" checksum="4C42BCFF2EEA6F92" modified="2024-05-29" version="1">MAALTFQPRPRLSVLARLAVLLAVGLWGQTTAGAYDTTVCGRTAYTIPSNNMTFNADAWNPDVKGFQCISVQDSPPAFAATWSWSSNPGMVHSYPHVKLMAPGLPTPLSNISALVLSAQWSMGPGPTPRPALVVDHDGLANHGTSANVAFDLFLDRNVANARSEQTAETEVMIWVGRFGYAEPLGFDANMEKTCFTQTVGDAEFVLYQGQNERGTDVLSWVATANHTNFAAEVSPLLQFLWRKGLVSAGSHLGLVEFGSEAYHSDGIVTFAASEFDMHLVTGAAPNLAVGDLPAECSRAASTNPPQWLLSSASVVSATLLYLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0V8</accession>
    <name>A0AAE0J0V8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_334872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677022.1">
        <property type="nucleotide sequence ID" value="XM_062823553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0V8"/>
    <dbReference type="GeneID" id="87860707"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3334856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="645" mass="69703" checksum="64C5BAFC7E448ED6" modified="2024-05-29" version="1">MDPELLKYYQQQYYPGMGFAGPQHTQHHGPQYQVWNPNSYQWTVLQQQRAAMMVGPGSLHPSKQTEPKPRLAKDEVELLEREFAKNSKPNTSLKRELAEQMGVEVPRINNWFQNRRAKEKQMRKTAEFEAQQARERAESESKPSDDQDQGAVTEFYGLSNRHQPLGLSTASIGNEDGANNDQSDRQRPNLEQSDLVLAGNASATQSSASPSGSDSDGFASADYDTPHSSGSRGYGLVSLATPTTVSNSYGSASNHMAYPQPAPFPYGLNEPPRPVGGLPVATMPQHDGLLSEANQFGSFSERSMFMHPSDGSFSSQMGGQDGTGNGTAEHPTVRMSIEGAINPENMSPSSGTGSSPVVADLRLRSPPPPSDIASRRNLRRPPPLGPLSLRTDCTGNGPKTGIDVAPRRIENARTIRRISSATGSLTGRIQKSMTLNSGGPRSPFTIDRKKSALLQSIQSVQSPIMASLNSAMSPMTNGSDDEQAYTFGSLGAVSEMSMPPFKSEAGIKTPPGTPGLGVHFRDPFAYPVPADNAWNYVSPDEPLPTPGLCSNGGSELDYSMAPQLSGYVTSQPVTPSFAPAIGPTYNNVFGTNGGSHLARNTEYTFPESYRPESSSRCSPVGQLRAKQQFQFAQNVTPQNFNNHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J152</accession>
    <name>A0AAE0J152_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_338592</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677115.1">
        <property type="nucleotide sequence ID" value="XM_062823603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J152"/>
    <dbReference type="GeneID" id="87860757"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="353"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="225"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3334949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="645" mass="72898" checksum="12F11348CA131F77" modified="2024-05-29" version="1">MADENCANSLLLGWVKEWWDTARERNTKGAPTYKKAYNSLKSCPLTFQHPSELKVLKGFGDGITSRLTDKLKQYCEENGLPMPKHPKRKRTLELETALAEAGAGQDEQPSPPKRARKARPYVPKLNSGAYALLMALSDPGPSGYMDKTALIAKAQPYSEHSFTVPSMANKSYTAWDSMKTLDDKELVYIRGRPTKKYSLTDEGWEVVKRMKEARNLVDGVGGSAITSGNAIASGSGTSNANRSENVNPNRPDSGVKRESRYTPLDLKPFVSATTTQERPPQPKPRTAISESYVLIDSDDEDFKYDEEDRKPIIRETTNHEYIDLVADGDSVPDESSLPHFVPIRLAPGSFTVELVLDTREVQAKNNRDHIQEELSKLGVRPIMRSLELGDVLWIAKCKQPGWLNRLGAEGDEVVLDYIVERKRLDDLIGSIKDGRFREQKYRLRRSGMKNVIYVIENFNIDQDNRTKYQDAMDTAMASIQVVNGYFLKKTDAIAESIKYLAAVTYMLKEIYESKPLFVIPTNVLTAKNYLPLVKHLREKEPSKGYYISYPAFASLVSKSEMMTLRDVFLKMLMCIRRLSGEKAIEIQKVWKTPYQLVKAFEECGTDENGKKKQRALVASMLSRLVDRRSVDKGLSEKIADVWGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1A8</accession>
    <name>A0AAE0J1A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_341374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677247.1">
        <property type="nucleotide sequence ID" value="XM_062823651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1A8"/>
    <dbReference type="GeneID" id="87860805"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3335081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="31848" checksum="80A46948D55A9036" modified="2024-05-29" version="1">MVDTHSLQASKLFNVDGWACLVTGGGTGIGLMCTQALAANGARVYITGRRFEVLENAAKEHSPKEGNGKIIPIGPCDVTDKDSLQSLVDKLSSLEKHLNLLVCCAGISGPKADPGVSSSAKDIAQELWSKESFSDWSSVFTTNVSSVYFTTVAFLPLLQACSKSHPQGHSHMSGNVIVISSMSGIMRNAQKHFSYNASKGATVHLTKLMSTEFEKTGVRVNSIAPGYFPSEMTTGESDEKNKSELSDEKVKGHGHKVPAERAGHDEEMAMAVLFLARDRYVNGSVICVDGGVLGVVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6T0</accession>
    <name>A0AAE0J6T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4238 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_309012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677425.1">
        <property type="nucleotide sequence ID" value="XM_062823262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6T0"/>
    <dbReference type="GeneID" id="87860416"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3337974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="91807" checksum="58045BF670638239" modified="2024-05-29" version="1">MSHPKPNNMAPAASNGQYQHFVPQFLLKNFAHRVPKAPKAPKGTPKPKYEKGMFPGDLVISSLDMTQDAAAFTEKPVSRILGQINMYDDFITKPDKERRHVEKLLSRLEAQAAQIVTKVTKALEAKEPAVRLMWDERSLLRKFLFLMRYRNIVFYKRFHHENSTEYSDQDREQLREYMAENPQFKTPIDVWLNNIKTIVELEIDPEFKWAREIGKHMYPDDAQWFLYNLQCNTMAFCVPSNPEEEFILTDNSYTVSDEVQVFARNVRSDRIETLARAPFHEFVPVSPKLMIVLRSQYLSEPLEDNCPEVKARREAHRSLAFAGFGPVQSVLEDLPIGKPHNSHVKVVNGRLCLRDGEDGCQRRDHSYLFHFFSVESRHVNTINSILLDKCVHCTSLIFNSKDAFGKTLEWYLTAPLEYGKTLIGENADLREKILMKLEVISRSFGSKKETKWTRVNKCHVAADHEYSRLVDQQVRRDFNRLLSGKTDKKPLWIDGIRAAIDEGVEQPESSHEGTSPGFTPTPQYRMLGGSVHTVEKDKEQTLLMMTLRIKIDYWSRGVDEKIRQRNRDLLIAEYLRMPARRLWGYMRIVRYMYLSDSFFIPIRLKPEQPEDAVIYAKDLIEPNSLTYLIYKAVQFDIELRKRPHVDIWGELSPDSESMALMTELAFRVQGTESILNCGIPIIENLAASLVSQTPFAGMALGIWSRNPRNPNYHPSPSPDFESNLEASLSLFNILHRTELALRVICRTRFLGIMESERSKHNLHPQTLQDLKKVFFTAVYPTPPDDWRYRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J855</accession>
    <name>A0AAE0J855_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_434859</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677773.1">
        <property type="nucleotide sequence ID" value="XM_062825159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J855"/>
    <dbReference type="GeneID" id="87862313"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="716"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="765"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3338322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110050" checksum="29C5CC528202E964" modified="2024-05-29" version="1">MSKFSQYLGDPPAIDGKSTIDPIVNHGHQDLVQAVAFNSYGDRCATGSVDGKIRVFNRHKDGKWRVCDSWSAHGGEILELQWLPPTIYPNLLASLGIEGRFKLWAENPSAAPGRRFGVNLTGHGGGHGASTLSSRRDVGGGLSSLSSGDSKPTPAFDYRNPKSPIRSFSLKHNDDTRHTYLALLSVDGTLEVLENETPENITEFSRIDQFTVCPKPSRGEEASFRVRFDPNPEVCYTALRAGVPTDALGLVVAAMDSVKVYRTRDTVSASLGVATAAREFYLAAEISGKDPNAGHRGLVRDVAWAPGNIRGYDIVATACQDGYVRVFGLSTPAPQTQTQGMEGTRGWGVGEMRRHQEGRREEGGGGAAARALAGSAAMGHGGGQDTHLKSGIRAGLADQSRMSGAAGDRMRAGGQQQPGQVRHVVTEVARLDSHRTPVWRVGFDDDGQILGSVGDEGNFENIPLTDTPNTPVKTDKTPKQNEDTPRRPTPARLIIGDGLVPSHDFKQTSEESKASTFLHRMFSFESPPGLPELTLMPNKGGAEIRTSLDAESIFNQFFPVRSTSSSYPSEGVKSPELTVSPPMTFGRRILSSLETYGFSNSSFLRSSDESAGSNQRHRLNPVAVEGALRDLYREQEAAKNNEVIECGTQPSVTGDDRSIKITERELTKPEVEHIENIEHRKMPSLNGSNPDEVIADISAVNTESIISLAIAALHRGKSNSSTLPRQRPRSSGPSGTGATPFPSLDLAPRDRAPVSSKAALLSEEAPSNLSTQCLPRVSTNPPRLSTESPTTLEKRYLKPKSRAALPFPFGSPTKKRSVVVAPIVAPVTDISNVPLLNGSQGGAVRKPLGPYPRQQSKKKSSILRLLRYIFRRPVKAKKWVVRKFRAKRKAISKRFRAKTKARKERKKIVFESSKVEGTTVPPVTSEEVESVIVPVTVLEEPAVATVAAVTEVDAVKAELGEVERIASDEHVAVTKQELTIKAVVEKKIGSDVGSVEEVEDVTAEIVEIHVVDASTCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8D0</accession>
    <name>A0AAE0J8D0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_432377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678314.1">
        <property type="nucleotide sequence ID" value="XM_062825000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8D0"/>
    <dbReference type="GeneID" id="87862154"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="64" mass="7081" checksum="F7AB2763B62DF01C" modified="2024-05-29" version="1">MSFQYQIGDVVCIRGASLRYKVIAVTGSMITIIVVNPQPDGQYLPFTSTSLQSVDESRIEKVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8K7</accession>
    <name>A0AAE0J8K7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_326121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677998.1">
        <property type="nucleotide sequence ID" value="XM_062823470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8K7"/>
    <dbReference type="GeneID" id="87860624"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="199" mass="22753" checksum="A9A13E14F915C1B2" modified="2024-05-29" version="1">MVTSGDDRDPGKTVPVVFVFSNDQNCDFMGKQRTMDDTVTGQSREQAWIDIWPLEDQVREVGKIWLTRRELDVFLSQTFEGSLLLPTVWAQDTRQFTYKTRGQPFRNASWNPTAFLGLTQHRGCCWTEFGQYCLETSPCLLLHGDFNVRLTTTSSIRCQQRIDTPLSCEKYYHTGGLYVLASKATESSSCLKRGASRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8N3</accession>
    <name>A0AAE0J8N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_288817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678413.1">
        <property type="nucleotide sequence ID" value="XM_062822981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8N3"/>
    <dbReference type="GeneID" id="87860135"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="267" mass="28971" checksum="259886011242956D" modified="2024-05-29" version="1">MASQTTATDPTPTTGTGNARFNTDAANWDSNPSIQLATSLAFESYLSRLPPPSELSSFNVLEIGCGTGLLSLLLAPHVRSLTAVDAAEGMIDVLTHKLSSVGSHAQIKNVRPVACLLEDPEDPIIKIDPVTGEAWDGNMKFDLVISHLVLHHVADLSALFKTIYGTLKPSSTHGHQKGGGRVITTDFENFGPEARRFHPEAKMEGVERHGITKEEMEGVLKGVGFEEVKVERGFVMQKRVESEPGKGDMERGPVVEFPFLVCEGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J8Q1_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_281374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678076.1">
        <property type="nucleotide sequence ID" value="XM_062822881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8Q1"/>
    <dbReference type="GeneID" id="87860035"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="726" mass="76506" checksum="5587C91B9DDEC6F8" modified="2024-05-29" version="1">MRATAPNLRRRNFARAEATRAWVEATKRQALDTSDDSLSDANSLNSLSDNSLNSLSDDNSLDSDSDAGRQPPPQTTNPPQLTGAAKTRQRLTAGSRGRVTRRSLEQRQVINTSDDNSVDSLDNSLASADSSADEARPLPTSTRRPNLSSKTRARLAAKHRRALDARQALDSDSADSVNDSLDSGAESSADEARPLRRPTRTQKTRARRAIDARQALDSSADDNSLDSLSDNSLNSQNSLDSGLSDGNSLDSNSLDSASDSDAARPLPTNPPNITSKAPKRLGAGSRLNRREILGTHHDLVASAEAAAEAEVPTIAPRDLTNAPAKSAESEEEEEEYDAYSVSSVSSDEEDEKDEKKEKETGTGTANPTATATDGAAATTVGGTATATITSGPPTTSEPADALAPVNSDDATALPTLTLAPEHSTASPSSVLGAIDGQPQADTQGQQTLVPVPKKMSAGATAGIVLGVLGFIALCTGFFFLFMKWRARRRPSSVFGTRLADDEKGGDNRDMPGGNVPPVRITFTRPSWPIQEPNQNQGGQNDTFQAQAQRYSKTNSEMINDLMRAAYATENGGAGGNNMAAAYGHADHYIDEKAYAMLAGQPPTPSVAGTEKRGVSKWLADVMTPRQSSISQRWPYPVDPPESLPSPVAQGRGMSGYGNNGTTTSTKQKRLTPPRLPLKPVMPASLRPGGGAGPVGGVGLPPGSNVNPRMTVVSQTTNTTSSTARWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8T8</accession>
    <name>A0AAE0J8T8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_580152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678489.1">
        <property type="nucleotide sequence ID" value="XM_062830786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8T8"/>
    <dbReference type="GeneID" id="87867940"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="343" mass="38892" checksum="FDF58B8BEA93EA34" modified="2024-05-29" version="1">MESTESSFVIVSPENSLFIGSPERSFVIESTESSLVIIHDYFDRPPPLTPGEYCGSREWEILNSSSKGATTSQLVDALDIVTDILDKKNIPYAVMGGFSLQLRGMQGVRQNVDLAVPLSILNTDASAWLTIFKDELRILRPSVFLSGVKDTTHKTIFVQVGDPDSDDNTTHWVRVDLRFFGHEHSSDTNLGQSLLPVLEEFENERDLVSSPLSLEKQYHCLNVGYVLHDKLCMIRRSSTERDIADVTYILSGHLVEVGDVSWIDMKLRTNFLGCYDALSPNDLMTDYFARALSLEGDYLWDRWTTIQKSEGSKPVPENKEWFWTRFFRRWSTPSKSSSQKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8V4</accession>
    <name>A0AAE0J8V4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_475496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678503.1">
        <property type="nucleotide sequence ID" value="XM_062827312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8V4"/>
    <dbReference type="GeneID" id="87864466"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="142" mass="16267" checksum="8E1E30572B574A0F" modified="2024-05-29" version="1">MKRPALPHVVIPFSPTLRALVCHQRIFPNAPCLIQSFSSFESSRGVTTVTELPPFLYLKFPFGNAFLKTVQMLSPCVFCVPVILWRLPSTSSSHLNESKRVSDMPDENVRYIWMVQITSKGWCQTSILRLDGLLCRLFFIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J937</accession>
    <name>A0AAE0J937_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_582592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677947.1">
        <property type="nucleotide sequence ID" value="XM_062830861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J937"/>
    <dbReference type="GeneID" id="87868015"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="336" mass="38196" checksum="29B734E56C3C8F26" modified="2024-05-29" version="1">MFCGLPKAVRSRMGHGANTKEARERNKLQKKQKKVQPTSNHQWKRQGETLECSTTTEIVSNQTPPTTSMDTRTTPLTQNRQITPENDPRRFHATVEDASDEGEPQPYRSAAATETESQQPTEATNSNNTETPNTSESNEHNDARPHSDQSQMQAPPSRHAAVVTEHMEAKNDIDTAISRVSSSASSTSESYSCSTCTHRTRRSVGSFIYPAFPAFPVWESSPSLRARGMRDKNEHKNKHENETKNGTKNRLRTIVSRITLALEERLVSFKEKRKEKRAQKEKAKQEWKEEVARRYTSGCPWTYNDNFTTFSEQFDDEIIFASILDYLDPATGHPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA07</accession>
    <name>A0AAE0JA07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_476482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678791.1">
        <property type="nucleotide sequence ID" value="XM_062827366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA07"/>
    <dbReference type="GeneID" id="87864520"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3339431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="125" mass="14127" checksum="63D5F2C90E207D5D" modified="2024-05-29" version="1">MGRRWLGRRASVATMPFDVGKTRTQVYRDTGTATQAAIVAMEKSAARPEERNMARLLWHIFSTEGVAGLFRGWIPRTLKMAPACAIMISSYEVGKRAFRGVNERAAMKEREELAQQQQHDLSKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA47</accession>
    <name>A0AAE0JA47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calponin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_431597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679088.1">
        <property type="nucleotide sequence ID" value="XM_062824953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA47"/>
    <dbReference type="GeneID" id="87862107"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="718" mass="80848" checksum="D2A5512F0EEE10A5" modified="2024-05-29" version="1">MAFAEQQQWITVQQKTFTKWLNTKIEVRGLEVKDLVKDLSDAVMLIHLLECLSGDSLGRYAAKPKLRVQRFENANLALNFIKSRGIQMTNIGAEDIVDGNRKIILGLIWTLILRFTINDINEEGMTAKEGLLLWCQRKTACYDEVDVRDFSGSWNDGLAFCALLDIHRPDLIDYDALDKSDHRGNMQLAFDIAHAEIGIPKLLDVEDVCDVAKPDERSLMTYIAYWFHAFSQMEKVENAGRRVEKFFNNMQGAWEMQSAYERRMAALLKTIQEQIVSWQGATFDGTYADAKAQAFQFASYKKGKKREWVAEKSDLATLLGNIKTKLATYRLRPYEPPTHLKMERLDEQWSNLSKAEMSRGQLINETIRDIKDALRKSFADKANDFALALNTMQLAISGLEGDVEDQLHHVRKLSENLPPLDAYLKTIEAVDLKCQEANIEENDFTTYSYDELCYELSLVKSSVSKKLAFLENQMVARNMTNLTPIQLEEFESVFRHFDRDDTNSLSELEFSAALASLGLVFSEDEMHEYFLATSNGRDRVTFEQFIRFMVDVTEDQNSADQVFQSFREVADGKPYVTEMDLRHSLVPDEVIEKLIEIIPKHTGPDMQSDRGMEQYDYIAFMEKLISEQEGRAASASSRRSSRASGVASGAAAPGQMPNHNHTASVGGGGASHSRHNSHASVGGKSVLGGDKSNGLMKSPKSPGTPGTPGTNNKPNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAE1</accession>
    <name>A0AAE0JAE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_246774</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678973.1">
        <property type="nucleotide sequence ID" value="XM_062822409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAE1"/>
    <dbReference type="GeneID" id="87859563"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="72"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3340031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="500" mass="56432" checksum="B114D406CE21BC1A" modified="2024-05-29" version="1">MSKSTDSDVVTKGDLQGPSSSPKSFSHEYNSDSQSTELVQEQPKRSWRSYVWDTLDKSPEERRFLFKLDAVILTLASLGYFIKYLDQVNITNAFVSGMKEDLKLFGNELNYMQTCWTVGYVIGEIPSNLLLTRIRPSIWIPACEVVWAIMTILLAKCKTTTQVYVLRFFIGLAESVFYPGMQYIIGSWYRKDELAKRSCIFHASGAIGTMFSGYLMAAVHKNLAGAGGFKGWQWLFIIDTVISLPIAISGFFLMPDLPEITKAWYFSADEIALAKERMRLEGRAPRAPYTKAKFKKIFSSWHIYLLTALYIFFNNGNGASSQPAFQLWLKSKGRSITEVNTYPTITAAITVITTLIYAWTSDTVFRGARWPPIVFSGLVNIVIYSSLAAWNIPDGWKWACFLLAGFGGGISGLTFAWAHEICGDDNEERALVTGTMNEMAYVIQAWLPLLIWQQVEAPVYHKGYMTSIFIAVAMIVTAFLIRFLHHKERANKLLAEEQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAN4</accession>
    <name>A0AAE0JAN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_444480</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679420.1">
        <property type="nucleotide sequence ID" value="XM_062825685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAN4"/>
    <dbReference type="GeneID" id="87862839"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="17">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="16">
        <location>
            <begin position="376"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="18">
        <location>
            <begin position="606"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3340478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="668" mass="73862" checksum="F17B7FFAE4F2BAC6" modified="2024-05-29" version="1">MAQNGKDPSRRVTRTLQRASTSIAMGSSVAPQGPVHQLRPKLFQHLKATSDEESMTVNTTDRLVALRSLMKERNVDIYVVPSEDSHASEYIATCDARRAFISGFTGSAGTAVVTLDKAALATDGRYFNQASKQLDENWHLLKTGLQDVPTWQEWTADESAGGKTVGIDPTLISPAVADKLNGDIKKHGGAGLKAITENLVDLVWGDSRPPRPSEPVFLLGAKYSGKGSAEKLTDLRKELEKKKAAAFVVSTLDEIAWLFNLRGNDIPYNPVFFSYAIVTKDSATLYVDESKLNDEVKQYLAENGTEIKPYTDLFKDTEVLANAAKSTSESDKPTKYLVSNKASWALKLALGGEKHVDEVRSPIGDAKAIKNETELEGMRRCHIRDGAALIKFFAWLEDQLINKKAKLDEVEAADQLEKFRSEQSDFVGLSFDTISSTGPNGAIIHYKPERGSCSVIDPNAIYLCDSGAQFYDGTTDVTRTLHFGQPTDAERKSYTLVLKGNMALDTAVFPKGTSGFALDALARQFLWKYGLDYRHGTGHGVGSFLNVHEGPIGIGTRKAYIDVPLAPGNVLSIEPGYYEDGNYGIRIENLAIVREVKTEHQFGDKPYLGFEHVTMVPYCRKLIDESLLTQEEKDWLNKSNEEIRKNMAGYFDGDQLTTEWLLRETSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB53</accession>
    <name>A0AAE0JB53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_258347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3340409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062822585.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="80" mass="9028" checksum="60A4CE0A2A3EAFB4" modified="2024-05-29" version="1">MYGISTYGPHKQPSSSAKANGFLQWKLVILSRLGPDTFLTLQPCQSQRVPCSSDQSTAQVERVDLWEFLGSIHPRRVRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBH7</accession>
    <name>A0AAE0JBH7_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_510442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062828402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBH7"/>
    <dbReference type="GeneID" id="87865556"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
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            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="466"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
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            <begin position="520"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
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        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBL8</accession>
    <name>A0AAE0JBL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor hoxa13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_474421</name>
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    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679994.1">
        <property type="nucleotide sequence ID" value="XM_062827244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87864398"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="568"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3341052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1310" mass="138536" checksum="1D95D158C225FCE9" modified="2024-05-29" version="1">MKDTNGSMNGGPKGPVPTLDGLSSINGYSKKGVNSINGINGINGPIKPTLSHSASPRVTPRQRPRSRPGVIARTFNVVARLVTWYTILTILFRCPASLKDCDKSSPRICKTYFEVKQTVLPHVEPYYTAYAAPYVNRYYHVVDQKAIAPALAYAQPRIQKAQAYTKTHWQKTLQPQLVKYQKLAKTRYEQSVGPHVKQLSTAAGPYYEIARTNALQTYHDVVVPSYHFVEPYAHKGYKAASAFAASTVLPSTRWAWNKTNLFLDGTVMPHLRVIYSENVEPQLLKIGQRLGRHTTSNKKSVPKPPVDLSSSSKTSTFSKPTPATTAASTPSSHAESSIKAAAAEEQKVLNSESTEHNVPENRIPPPEVDEQLEKEDPARRSARETVAADLQDWQERYSKAADQGASEISARIYEITKKMIRRNAKVTGKALLDELQTTTVSELVQLRRKIMQIIGAVNKETASVDEGRDQIAAVVRQAGMSIKERAQEVRTWRENYEAEMQSAITNAAEAHFTILGDIRDLALQKLGMKWAWMDGVTYKDWAKYHELKSRFEDWNNDLKNLIVTHPGLEAAQNEAAAVEEEAMNTAASAAKELARLKQVAVRKLEAGDDSDEFESTVAQQAAEHVEYAQDAAASVVSQASDSASAAGEKVSEVVGDGVSRAAEVVSEVTEAVVGAKDSATDKMEELADEDTSPVVEAASSASESVESATDVAKESATTVLSEASEVVVGSSTETETVESASVASEEVADDVESASEAASIVESRPDLASTEILEETPVMVGNTTKAEKEGPAPVELPVEEEAEEESDIIVSETPEPPATTVKSAWLGAAAQSVPSRQPIIDEDTYDDVSEAMEKMRNDVKSVYSSAMSRANNQYSEALSLISAQIRGTPEPAHQQMLASVTQAYSNAMASASVRLDKALKLASKQVYKSTPTEAFKILPTAVPVPNIPSVDWERIQSIAAQRLEQGRSWAEEQYESAKIAAGLATPTPSTPSEHVQKALENARHNYYAGLGVAHARYSEFLAAASSAFNSLTATPTPTDFVGTASSVASVATESAASAASVVTDNAAYAASIASESAASAASAAAASAASVASAVTDGAASAASIVGENASSVVYAAGDKASSAASVVSENVAGAASVVSENVADAASAVSESWDSVLARISIEVYGAPTPTPWYQTVISAASAASSSAISVANQYGGAASDAAADNAASITSAAGAGASAAGEYAAAGTDAAAQQYSVVSSIVSELLVGKEPTFSESVVSRLRGVYATSIPEVVVGAYESVSSLASEAKETVVSVASQASEAVVGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBU2</accession>
    <name>A0AAE0JBU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_551427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679974.1">
        <property type="nucleotide sequence ID" value="XM_062829807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBU2"/>
    <dbReference type="GeneID" id="87866961"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3341032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="737" mass="83505" checksum="23E02A479AC8CCB4" modified="2024-05-29" version="1">MEMDDHTSELIDISRYDTHGFCPGYTLRRHKAETLANAGCYEARKDWIQYIGPVEEFGNCNPVNGNFTAVVLPLTKPERLRLVAYILEYAFLHDNVVEVTKDDASTTTAFSLGDMETSHQNAKLGRKQIQAKMMLQLTQTDPVCAKRVLDVWQTMLETTTKDKSKSFANVEEYLEFRIIDAGAPFVESVMLFGMGETLTKEEDALLAPIIRPCYASLALANDYFSFDREWAESLSSPDAPKPLNAVWLYMQWQSVDMATAKWLVREATNQFEVEFLEGCRKFRESSGKSNDRLERYLRGLQYQVSGNVVWSLNCPRYHPDWRYEANEGLEDGLTVEWRGSPLLHVAAAAEQVEDVSVSDLMEATAKRLSITSWGSRESESDVSTTSSLWEDRAASSRSSSVSAMPSDDERHDGMEEFKNAEREKESLDSLVPREEKLGMEIVNAPFEYTRSLPSKNVRATFIDALNLWAGLPEEVLVQIKEVVDDLQTASLMFDDVEDGSELRRGNPAAHAVFGVPQTINAASLAIVEAVRKAKGLPIPGAVDIALEQLRDLHVGQSYDLYWTRHMSCPSESEYLEMVAKKTGGLFLLLSRLMSEHMPKEVRSLVNHLVTQVGIYFQIRDDYHNISSDEYTAQKGFCEDLDEGKLSFTLVHYLNTEGQSSSSQQVREVLQERQQRGSLSMPLKLLTLQRLKSSNSLEYTRDTLKRLERGVDRTIEELERLTGRKNWVLRMCMAKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBX4</accession>
    <name>A0AAE0JBX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_498857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679771.1">
        <property type="nucleotide sequence ID" value="XM_062827820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBX4"/>
    <dbReference type="GeneID" id="87864974"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="38"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="475"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="595" mass="66764" checksum="D99954F07D216D66" modified="2024-05-29" version="1" fragment="single">MSRGHIRLLQLLPSKNEDAAIHCQLFCTALDSKGTRPYEALSYVWGSEDKPCSIFIDGCNLAVGKNLYAALLHLRDHSIQRTIWIDAICINQGDNEEKGHQVQSMAKIYAKASRVIVWLGEEAAGSDQALEEIRIAAELSTRRLDNKAGILPLLQRPWFQRIWVLQEVAAARHILIKCGSAEVDGFAFCSGLNALNLSNELPADLQARILSVTYLIRGAIFRPKYATSQSDNFSLDIRPLGELIEMYHTREATDRRDKVYALLGMSSDNPTAAGLFADYKISWKQLFNKLIHFFLSELVSVVGLSDDKENAVIEGKGCILGEVSSVKRNATWEDRQDVAITWSNVLSYICVKEAWGSCWTLPTTVKSVQKGDVVCLLQGASRPTILRSYNDHWAVIMIAVSPAGDSQATTGDIKWSELLQPITVFPHNFRLIWDWDINANKQQDKNNYDYFASIPEHSKTELEGCRNVATRIRNVRLALQEVKQYEVAVKNLREETAVLERALRSMSNLKKTCVGSEDSEQEDAKETMVNQLIEDKGQWTLLCLAAGNGHETVVKLLLNTGKVNLHREELRTARWFAAQKGYKAIVKLLLDTGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC77</accession>
    <name>A0AAE0JC77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_473072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679582.1">
        <property type="nucleotide sequence ID" value="XM_062827178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC77"/>
    <dbReference type="GeneID" id="87864332"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="174" mass="19323" checksum="27C7062FB4FCCB6E" modified="2024-05-29" version="1">MASDKQAPAGAAATNQPQGSAFSLPLLYRLFFLLIEPLSALLGAYYAYFDKKAYLELTHAASAPETIPLGTSIVLSQLANLYFFFAINEALVLRSTSDIRVWKTVLFCLLIGDIGHLYTVRELGLNIYWSPSTWNAIDWGNIPFVYLGASMRIAFLADMGLYKSGKRLQKKRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCF3</accession>
    <name>A0AAE0JCF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_509451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680098.1">
        <property type="nucleotide sequence ID" value="XM_062828314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCF3"/>
    <dbReference type="GeneID" id="87865468"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3342305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="627" mass="69228" checksum="8DC0FCDDE9C4324A" modified="2024-05-29" version="1">MHLPTPCSSCLDWARLLQSILHLGPSVLHLSERVTVYIRTKTTLLTSIVTGLIRVMYPFNIGPATFLAGALTLTQVVTATPFPQPQQKQIGTADSAASPHAVSNQERRDAVKQAFQISWDGYYKYAFPHDSLLPVSNSYDDDRNGWGASAIDAFSTALVMRDWSVVSQILSYVPKIDFTTTSSEISLFETTIRYLGGLISAYDLLTSKPLASDPAFNYTSSQTDAILSQAVRLADQLSVAFNTPLGIPDNQLIFDPLTGPRRTGSQTNGIATIGTLVLEWTRLSDLTGNPKYAQLAQRAESFLLNPQPANVAEPFPGLLGSNVDIATGLFVDSSGGWGGGTDSFYEYLIKMYLYDPDRFGLYRDRWVLAADSSIQYVASHPSTRPDLTFLGGWKGTTLRFSSGHLDCFDGGNFILGGLTLSSQKYLDFGLELVKSCAETYSSTATGIGPELFSWQDSRTPLNASNNPGPSTAEQKAFYAKNGFWITNGQYVLRPEVIESMYYAWRATKDEKYREWAWAAFQAINATTRAGSGYSAVENVNKAGGGSKTNFQESFWFAEVLKYCWLIFQDDDDPWQVKSDKTNQFVYNTECHPIRLAKGKETEPSSSSYQQGGGKEKRDRRFAGPRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD29</accession>
    <name>A0AAE0JD29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_469708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680700.1">
        <property type="nucleotide sequence ID" value="XM_062827024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD29"/>
    <dbReference type="GeneID" id="87864178"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3342907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="310" mass="33620" checksum="31EFFD3E779C3288" modified="2024-05-29" version="1">MENLPTTYDGPVHIAVIGGTGLSKLDGYVPVAALNPVTPWGSPSSPLMIFEHNGHAVAFLARHGLYHQLAPHEVPARANIAALRSIGVRTIIAFSAVGSLREEIKPMDFVIPDQIIDRTKGIRPFTFYEGGVVGHVGFADPFDAGLAAVVEKCASAMKGDGVVLHNKGTIICMEGPAFSTRAESHMYRSWGGSVINMSALPEAKLAREAELAYQMICMATDYDCWRGESGEDVDVAMVMKYMAANGENAKHLVGAVLDELLKQDNSDLVLAKKWQGSAQGAVKFMTKPEGRDPEAMKRVEFLFPGFWEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD35</accession>
    <name>A0AAE0JD35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_230924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680603.1">
        <property type="nucleotide sequence ID" value="XM_062822177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD35"/>
    <dbReference type="GeneID" id="87859331"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="213" mass="23407" checksum="B40589F3E5A6BCB0" modified="2024-05-29" version="1">MHALPCHLDIPGGTVIRTWATPSPDRVSRVNYGSTTGQLWIFLTTQNRETGGRRRRPPMAHGRPCPEGLKRTRTPLPITIRRVETPPGCRHRLPASLTNCAKRRALKSFTATGLRTVRTWLKWGFGAGQRVSGGGARLSETMLTELTPFDRRGDRGAIFSQAGSKLISPARAVIETRKIRTHGNMEYGQDGGYIGGDGIPSDLDGRHGSREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD48</accession>
    <name>A0AAE0JD48_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_235679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680774.1">
        <property type="nucleotide sequence ID" value="XM_062822259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD48"/>
    <dbReference type="GeneID" id="87859413"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="286" mass="32866" checksum="582E655DECBFBDA7" modified="2024-05-29" version="1">MVEVLYSTPTLLQGSGLPFTREDHRRKEMSLMRSGKRVPRRSQTFQEYHIPQPPLFTLHTIQQLPEEDVAKQPVVSVKERSQPKPTEEKVTVLRRPALGPPRRSYSVTDRLPLPMPSAGKLLLDLPPELHMAIFDFLDPIDSTCLGLTNKHFYAIHRRMHGTVPLRTRREGPNELEWAWHLAGTVRKSAPCSPVEEKSEEESKKSLSLSQLRVRGQAYCRKCGVTRCQLHKHIQEWMGDNMEYCSIREKYGPIAPEGAKSYCYMSKPGDKTRCGRHFVRKSKVVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDB9</accession>
    <name>A0AAE0JDB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_240269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680890.1">
        <property type="nucleotide sequence ID" value="XM_062822309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDB9"/>
    <dbReference type="GeneID" id="87859463"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000534">
        <property type="entry name" value="Xyloglucanase Xgh74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042186318" description="CBM1 domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="9">
        <location>
            <begin position="819"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3343097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="855" mass="88588" checksum="AD88E4B3DB5F8F72" modified="2024-05-29" version="1">MKSFSVIQLLLAAAAAPVRAAASWKNVNIGGGGGFVPGFVFHPTEKGVAYARTDIGGLYRLNADDSWTAITDSITTDAKWNNWGIDAVALDPQDPNKVYAATGMYTNSWDNNGAIIRSSDRGATWSTTELPFKVGGNMPGRGMGERLAVDPKNSKIIYFGARSGNGLYKSTDGGVTFSKVSSFTAVGDYIVDPSDTTGLNSDKQGIAFVTFDSTSATTNGATSRIFVGSATNSTSSVWVSNDAGATWSAVAGQPGTYFPHKCKLQPTEKALYLTYSDGMGPYDGTAGGVYRYDITNGTWKNITPVSGSDLNYGFGGLGVDMQKPGTLVVASLNSWWPDAQIFRSTDSGTTWSPIWEWSGYPNQNFYYGLTTPNAPWIEAGFISQDSKRLGWMIESLEINPLDSDHWLYATGLTVYGGHDLTKWDTVHNVSISSLAVGIEEMAVLGLASAPGGSELLAAVGDDCGFTFKTSADLGTSPKTPWMTPMWATSTDVDYAGNKPANVVRIGNGSGSQQVAVSSDGGASWTIHNGTDTTKNSGTVAYSADADTIVWSSGNAGVVRSQHQGTFTAVASLPSGAVIASDKRNNTVIYAGSTNGTFYRSTDIGATFTAVSGALGSAKAVRDIVAHPTVAGELYVSTDVGVFRSTNFGVSFTQLSGVTNTQSISLGVGSASGSWNLYAFGTGASGNKLYASADAGATWTDVQGSQGFGSISSNKVVGSGNVAGQVYVGTNGRGVLYAQVSVSGTAPATTSSAVKTTSTSAAAPVSTTSTTSKATTTLVTSTVKTTSSISSVKTRGISTTAKASSTTSSTSSAAAPTGTNLAQHWGQCGGVGWTGPTACVAPYTCQKQNDYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDX9</accession>
    <name>A0AAE0JDX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoD-like phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_463781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681165.1">
        <property type="nucleotide sequence ID" value="XM_062826721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDX9"/>
    <dbReference type="GeneID" id="87863875"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF8">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042228628" evidence="2">
        <location>
            <begin position="46"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="3">
        <location>
            <begin position="202"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="442" mass="50288" checksum="C4849740CFCA4174" modified="2024-05-29" version="1">MIKPITTHVKPVSSSRSSHRGPRFTMHSNLGSLLGLAALLPLASASFQGNLNYHPPSARSSQINLGLSLPLVTSRTLKRSSVAYQPSELNFTHRVASGDPYHNSVILWTRVAPTAESDRSNVTVAGTVDLYSHEREKYIKADANSICVEWKVWGLQKGYNGTVKGPVISNGKAYTTSDIDFTVKVEAQGLKPWTVYSYQFNVAKGFFNVYGNAARKDKHDYVVHLGDYIYEDASGGPRAHKPANKLFTLYDYRTRHGQYRTDNDLQLLAQNYAWIPTWDDHEFANNGYRNGFSALNNTEASFRNDGPSISVDTRKINAVRAYFEWMPIRQVDLDDNLRIWRNFRMGKLLDLIIIDTRNYDRSITSTGTNDEYIELIRDDPLRTLMGGRQEKWFFRQLSESKQRAATWRVVGNQIVFSRILDSQGVLTGTDNWSVVRWPKCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE39</accession>
    <name>A0AAE0JE39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UbiA prenyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_243079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680983.1">
        <property type="nucleotide sequence ID" value="XM_062822351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE39"/>
    <dbReference type="GeneID" id="87859505"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3343190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="370" mass="41027" checksum="2BCE164951B76F23" modified="2024-05-29" version="1">MSTTTTLHNKPVPALRRLWSMFGTESWDRSTSTPKPKSDDDGRGSRSSESLTQQPLLPAGSLKGNVSAVISIVWAFTKNDIFTFSLPCVIFGAALSLAKDARTAPEPPTFNQVLSRLLGSSMFQFISLLLFDVDNQRDPTSVAEDRINKPWRPIPSGMITSDQSRRLVLFLVPLTMALGYALGVWNEALLVVIAAWVYDHLGGGDEPIVREVVLGISYAVFQIASLRIALGSGEYHAQTQTDMVADVISPSGYAWTAITGTLIATTIPIQDMKDQEGDRLRPIRKTLPLFIGDTATRYYLAVTIPVWSVVGTVFWRTPGWYAVPIMVYGGYIAWRLLAKRNRVADEASWRNWSRWLMLVYALPAVNALMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEP4</accession>
    <name>A0AAE0JEP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation protein SH3-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_548400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681221.1">
        <property type="nucleotide sequence ID" value="XM_062829579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEP4"/>
    <dbReference type="GeneID" id="87866733"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3344608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="136" mass="15347" checksum="4D1D2976DC09CBFF" modified="2024-05-29" version="1">MVKVNNSVSSSRRKSRKAHFSAPSSVRRNIMSAPLSKELREKYNVRSIPIRKDDEVTIVRGSNKDKEGKVTSVYRLKYVIHVERVTRDKATGASVPVGIHPSNVVITKLKLDKDREAILERIKRGRELAKPTKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF82</accession>
    <name>A0AAE0JF82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_424994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681804.1">
        <property type="nucleotide sequence ID" value="XM_062824544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF82"/>
    <dbReference type="GeneID" id="87861698"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="639"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="895" mass="95806" checksum="553D65FAE721E47B" modified="2024-05-29" version="1">MSSGTGKPALQAKAGQGNFAAGMPSTQAILLDKLNRGSTPDSEALASSDDEVDPLRQEPPPTSTQAPKQPVRRASWLNDTSQPPPPPRQRKESFASTSMSPTTSHPSTPAVDSGVGAWGTHPAASAVHGRSHAGPGPFSTTWGAGIWTNERNNPPSRLAEVLPSPTSGVPPGSSGGSFFDNALAQQSAGSRDAVPNPQIPFPIPLHPTPKTYRSQSYSVGQLDPETSLPSVATSAVLGGRSRPLGHPGLQHRPSRPSMLSEMANDGSMLGKVNEDDDDDSTGSLQGAGQQQSAQAKAIESLMRENAMLRQQNQYQSSRLRPRASTSNVFGLGNAYLQEAVPEESDFAVDELDEANDGSDFGRRNMARRMSEFGVGPYRTPYMADNRKVENVNLKRALWQTSLGFGGLGDIPQSRRHSFADVPVRQNSIASIGEGIAPHETGLHDSVPDYTSPGYPDAMALANAAQVQNYFAGGSSHALAQSAYGNQFSSPYSMLPNAYANRPNSPHRNMYGAAQPRHDQPLYIVLFKCARADVFYIQEGTGLTVKPGDLVIVEADRGTDLGTVAKDNVDWKTAKELKEHYAEEQYRWLMMYSQNAGMAQDGVGAGLMAASNLQGSAVGGMGPAGQHHIQEPNSGELKPKLIKRLAQAHEIHALREKEGNEAKAKRVCMQKVKEHGLNMEILDAEFQMDWKKLTFYYFADSYINFNSLVTDLFKIYKTRIWMSAINPASFASPTLGLQAPSGIGPGAVGVSRASAAAERRQNTQQQDQQSVYTAAGQTGRNIQGAFPGAFTPDRAMVPGSGYSLQTYPWNSYVPFGAASRPGPGLGGLSYAVPGMMPNSDTYTAGGFPPAVDYSARPRYPTPQASSGQHEQIGSAQGTQADWATAFQGLSLNSNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFB5</accession>
    <name>A0AAE0JFB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_539122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681232.1">
        <property type="nucleotide sequence ID" value="XM_062829109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFB5"/>
    <dbReference type="GeneID" id="87866263"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="636" mass="70590" checksum="B2B817E8E71CB1A2" modified="2024-05-29" version="1">MPRQYVLFGRPLPRLGSRHLSLLLVSVSLFAIFSLLFTLPSAIPTGPSLQIADHKLSIPDSIKNPWNKVNPFKQPAHAPPRQKNDTYGQSSWYANWKWLSYPFSSSVTLDESRSLLPELGQRPPIYVYYDNTIEREKATKEVESDILLSWRRAWWAQGFKPIILSPAEAMNNPMYEELQHRSEGMDASLKTDIMRWLAWENMGGGLLAHYFLFPMGAYDDPLLVYLRRGEFPGLTRWKDLGDGLFVGPKADVAKAIKLALASPNLKTAKNFLEATSASKEEGPFTIDDTEPSSLAFYSASALKLYPKVAETIGGDRVAGLKSLNELINAHLHQTWQNLFSEGIAVVKPLPQHTTHMIAPSYSVALRLASCPANNPLPSSCPPNRPKCVPCSTSAHLIKISTPAHYKNSSALYTIGTVPHPYTIQSLSSMREQITVPWIRRDSVRDAWVGDLMTDLFKGKAVPAGARVLRFKEALAGEYGSARSLWLTAERDTPEGILDWHFGFDLPALPSSSSTSTSGSPKEKEGGGEHKHDDATEKIESEIHKPKDTSILPPIHDEKEGPVPSEQDLKLEPNLLSLAKTIVSSASDEAENKNKKIHNNLNNKHKYGMVLVVTMLSMNTALQVKSFKDLKSGATHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFE2</accession>
    <name>A0AAE0JFE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_196659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681773.1">
        <property type="nucleotide sequence ID" value="XM_062821727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFE2"/>
    <dbReference type="GeneID" id="87858881"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000046">
        <property type="entry name" value="Nudix/MutT family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="164" mass="18969" checksum="A4BFDA3F72A3B474" modified="2024-05-29" version="1">MAASNTSSGNRSMESRTGRTKQRYNTKGERLVAGVVPLTADKYYVMLIQSTRRKGWVLPKGGWELDEECHEAAAREAWEEAGIVVQINYDLGDIQDTRPPKKNPTKEKERALYRFFEATVTSEEPEWPEKDKRERKWYTYAEATELLKERPELQAALDLSTIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGF7</accession>
    <name>A0AAE0JGF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_423799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682452.1">
        <property type="nucleotide sequence ID" value="XM_062824479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGF7"/>
    <dbReference type="GeneID" id="87861633"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3347370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="163" mass="18984" checksum="E33A1B4FCA0CC53A" modified="2024-05-29" version="1">MSVTTQVPKDFDAENADNFEDIEKQFAVKAVQQMATYWAILEKVPGSKLRLTKMDDDIFEHLKKDFPEFDPAVPIDEDEMKSKTGKDRWRTFMMAYDKKIDDYNFGTLLRASPKTEYGEKETIFVPRMQFYAVEIARNRAGLNDWIYEEAEKERQKAKGSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGI5</accession>
    <name>A0AAE0JGI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UbiA prenyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_574638</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682186.1">
        <property type="nucleotide sequence ID" value="XM_062830589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGI5"/>
    <dbReference type="GeneID" id="87867743"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3345573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="315" mass="33881" checksum="9D2F32D980BF5640" modified="2024-05-29" version="1">MSQTISTTKTALLARGNNDSASNKEKQPLPKSQLSQQYGGHHAGGWVDLFPTSWLSRLSPPTAFFMVFAPHLFGAIHAAATHHLPLSSVARVGSYLLSGSFFFSNAAHAWNDLVDAPIDAQIARTKTRPIPRGAISPKAAFLFTCVQAACAAVFLLPLPWDATLAAVATIVGTTYYPFAKRHTHFAQFVLGLCLKWGVMVGSAGMGVPAPWRDPSTATLVAASVVWMVIFDTIYADQDLADDLRVGVKSTAVLFGSWARPILFGLYLTMSALLVASGYWGGICWTWFSRGFWPTGAAIAAGLLVEYGWQQMVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGJ3</accession>
    <name>A0AAE0JGJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_460462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682527.1">
        <property type="nucleotide sequence ID" value="XM_062826534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGJ3"/>
    <dbReference type="GeneID" id="87863688"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="65"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3347445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="455" mass="49930" checksum="A3F824A7CB811AA0" modified="2024-05-29" version="1">MATAQLAYGVERIVGHGPEQIKQDISTYDPDKGTGDASQLMKALVWEGNKKVQVVEVPKPKIVEPTDVILKVTGSTICGSDLHLFHGAVMQMNKGDILGHEFCGIVDQVGPAVKKAQVGKRYVVSFQIACGDCFFCKNKLSSQCEVTNSNTQMKAMYGGRTAGIFGYSHLTGGFAGGQAEYVRVPLADVNMLEIPDDVPDEKALYLSDVLPTSYNAVKDTAVYPGDAVAIFGGGPVGQMVGVYALWEGASKVIYVDTEPRLSFVKSRWPAEHQDKLQLVDFKQLSYGITTKETVVSKLKELTGGRGPDVAIDCAAGEYAKGWLHWLEMQLGAETDTSEIINEMVEGVRNYGRVGLTGVYVGYTNHFNVGSLMQRGIRLIGNGQAPVHKYWEELLQKIRDGTLDPTIMLSHRVRLDDMDKVYHKFDAKEDAMQKVFVETKFSLPRAPGTPELTTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH94</accession>
    <name>A0AAE0JH94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_441454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682950.1">
        <property type="nucleotide sequence ID" value="XM_062825526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH94"/>
    <dbReference type="GeneID" id="87862680"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="93"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="329" mass="37079" checksum="10F1996914D93640" modified="2024-05-29" version="1">MFSWKSAAILCPGNAALATHGSLTLVRAATTSSSRLCGPLAVDPVFFDLRPIAPTARGAFQTRRFASVHHGAADAELPKDHPALHWPASKNPTPYDIFGQSKNDPYNKRRFHELVKLYHPDRHPHPGLRDIPHPTKLERYRLVVAANDILSNTQKRRMYDLYDLGWSNHPDLRYDDVPSNHNAWHRRPGNASMNATWEDWEQWRNEQESGGTGQQQKPIFVSNGAFVVIVSFFVVIGSWQHATHGVQSGVALLDAHEQTHAAINKEMRQRYGETAGLGREARVDNFLKQRNGWDNYPPHPHHISGYYRNLPSQAPPPQLPPPAPKHDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHC8</accession>
    <name>A0AAE0JHC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetrahydroxynaphthalene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_507590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682601.1">
        <property type="nucleotide sequence ID" value="XM_062828148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHC8"/>
    <dbReference type="GeneID" id="87865302"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="268" mass="28528" checksum="DDD13303F2A2B0A5" modified="2024-05-29" version="1">MPISIPTASLEGKVALVTGAGRGIGRGVALELARRGASVIVNYVSSAGPANEVVKEIESYNNGARAIAIQANVRSVSEIDRLFAEAKRAFGRIDIVMSNSGTESWDRVEDITEEKYDYVFDLNAKAQFFVGQAAYKHLEQNGRVVLMTSIAAGLMGVKNHALYNASKMAVQGFVKAFATDFGDRGITVNGVAPGGIKSDMFAENAWHYIPGGTPDLGKDKIERMMAEHCPLGRCAVPEDVARVVAFLASEDGGWVNGQIITISGGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHP9</accession>
    <name>A0AAE0JHP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_165518</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683175.1">
        <property type="nucleotide sequence ID" value="XM_062821294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHP9"/>
    <dbReference type="GeneID" id="87858448"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="347"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="776"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3348093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="793" mass="90239" checksum="8755391732FE1041" modified="2024-05-29" version="1">MEQVTEKVTETLKKVAIGGDKPQKEKKQKKEKAAAPAAGGDAGPLEMNPPPSFIQERLDLFDRLYKEQQEELAKRPHDDILITMPDGTTKAGKAYEITPAEIAKGISNSLFKRTVVARIDGETLWDLERPLEKSCKLELLDFNDDQGKFVFWHSSAHILGEACERRFGCSLCIGPPVDNGFYYEMALPGGAAVQSSDWAPLENIVTKIVKEKQPFQRLEMSKEDLLKMFAYNPYKQHIIKDKIPDGTRTTVYRNGPLIDLCRGPHVPDTSRIEAFAIMKNSSSYFLGDANNDSLQRIYGVSFPDKKQMAAHKKFLEEAAKRDHRLIGKQQELFYFEECSPGSAMWLPHGMRINNAIMEYIKEEYWKRGYDEVMTPNMFNVSLWEQSGHLAHYKDDMFILDVDKEQFGLKPMNCPAHAMMFRHRDRSHKELPLRLADFGVLHRNEASGALSGLTRVRRFQQDDAHIFCREDQIKAEVADLFDFMQSFYGMLGLTFKMKLSTRPEKYMGEIETWDRAEARLKEALDEFSTATGGTWELNEGDGAFYGPKIDIAVLDCLNRPWQCATIQLDFQQPINFSLEYMTAETQAKQDEGKPAPKAPEPEAPKEEEAPKEGEEKKKKALLVKKPLAPGCARPVMIHRAMAGSIERFTAILAEHFAGKWPFWMSPRQVMVIPVGMGFLDYAKEVALTLKKEKIHVDVDSSGNTLQKKIRSAQLAQYNFIIVVGDDEKTNRKVNIRYRDDTSTQARDVPYPLDEAVEKLRALKADRGMYNPFPAHNPKKEEAAKEETAKEEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHS0</accession>
    <name>A0AAE0JHS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_158103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682958.1">
        <property type="nucleotide sequence ID" value="XM_062821193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHS0"/>
    <dbReference type="GeneID" id="87858347"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF34">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="366" mass="39847" checksum="86EF43BD5BD98007" modified="2024-05-29" version="1">MASLLNQLRGLTTVDCDTFDAHVARIYGPFADCTSNQAIVLAEITKVDPNGKLIYQSLIDEIIPIAHWMFGKQTDATVEELAAELLAVGLALRFLPHLNGFIHIQTNPKWCYSTEKTVKNAERIIAHVKHLSPDFDTSRVCIKIPATWEGLQACRELEHRHSIATLATIVFSMEQVALAVDAGCRYVAPYVNELRVHFDATYTDANKDRAALFCGAAQRYCDEVASSASAAEAAHGFLSLQTRTQVMAASLTSVEEVMRLAGAVKHITVSPPLLTELEATPAAGWPGAGTVGAAAAITGPSATGDAVRLRELVRDQSQWRLAFTRAEAGESERKLGQAIGIFCDMQDQIERLVRRWDLTGKKSVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHW9</accession>
    <name>A0AAE0JHW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Na+ dependent nucleoside transporter C-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_441740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683275.1">
        <property type="nucleotide sequence ID" value="XM_062825543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHW9"/>
    <dbReference type="GeneID" id="87862697"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="215"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="297"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="400"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3348193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="623" mass="68241" checksum="E4764C46573485FB" modified="2024-05-29" version="1">MSSADNRGHADSDTIQPQYHDVTRSPIVDAMSSHGDATTKESMGPHAHEKPVISSTDSDVKTTIPAGQYVDAESQHHVGSVDREDKQPAERYSWAWFYGYGRPFIHAAIWVLFTAWWIYGALLKHRHDHLGWLKPTLVYLAICLRLITCYVPVSIVMRPAKFIWRHTVHRGYSMIPQKLHQPLAAIGTLGVFLLGSMIPEETGENTRANRGISIFGLIVMIFILTVTSRDWRKIPWHTVIGGMLTQFVIAVFVLKTKAGYDIFSFVSEMARTLLGFAKDGVSFLTDDTVPQMTWFLTGVVPPIIFFVALVQLCYHVGFIQWFIGKFAIFFFWTLRVSGAEAVVAAATPFIGQGESAMLIRPFVPHMTLAELHQVMTCGFATIAGSVLVAYIGLGLNAQALVSSCIMSIPASLAVSKMRFPETEETLTSGRVVIPEDDEERASNALHAFANGAWLGIKIAGMIIATLLCIIAIVAFINGLLGWWGKYWGLMGQDAAHPMLSLQLILGYLMYPIAWLLGVPKNDLRPVGELIGVKVITNEYVAFFSLTNDEPYKSMSPRSKLIATYAVCGFGNIGSLGTQIGVLSQLAPGRAGDVSKVALSALFSGVLSTLTSASVAGMLYNGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI27</accession>
    <name>A0AAE0JI27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_588026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683264.1">
        <property type="nucleotide sequence ID" value="XM_062830994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI27"/>
    <dbReference type="GeneID" id="87868148"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3348182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="466" mass="52218" checksum="D03DD821E3D19EC8" modified="2024-05-29" version="1">MSGQAKPTENMLWGGRFTGGLDPLMVQYNESIHFDRALFAQDITGSIAFARANAKAGIITQDEFSKLEQGLLAVKKEWEDGTFKIVPSVDEDIHTANERRLGEIIGKDVAGKLHTGRSRNEQVATDMRMWLRDELGKIEKHLQDFLNVTAARAEQEIDVIMPGYTHLQRAQPVRWSHWMLSYGFAFASDLERLREVIKRVNRSALGCGALAGNPFGIDREMMSKELGFDGLLWNSMGAVADRDFVAETLQWGAMLMQHISRWSEDLIIYSTSEFGFVRLADAYSTGSSLMPQKKNPDSLELLRGKAGRAFGHMAGFMMTQKGIPSTYNKDLQESWEPMLDHVKTVSDSIQIANGVLATLSIQPEKMKESLDPFMLATDLADYLVRKGVPFRETHHISGRCVALSEQTGIPMDKLSYEQLKGIDARFEEDISKVFDYEKSVEMRSAKGGTSKACVQEQIQVLKSMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIB0</accession>
    <name>A0AAE0JIB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_548167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683469.1">
        <property type="nucleotide sequence ID" value="XM_062829560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIB0"/>
    <dbReference type="GeneID" id="87866714"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="108" mass="11406" checksum="285E90054635CEDE" modified="2024-05-29" version="1">MGQNLSLSEPFADTSGVVLSPSDRHADIIVGITWACSAYGIGVIFAAVRLLERWSGEHGEKGVNLASVVGAFLCGSAWPLVLIYLMVTEKETRRGVQGYPGTIGVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIT7</accession>
    <name>A0AAE0JIT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_423166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683503.1">
        <property type="nucleotide sequence ID" value="XM_062824441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIT7"/>
    <dbReference type="GeneID" id="87861595"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="319" mass="34448" checksum="30B1ABF57356F826" modified="2024-05-29" version="1">MQRAVVASAVGARMLSEIEEGSLEEILTSLRTNFTTLSNSDFNDATHDTDPDHDVTTTSSQAQKLIAPTTTTKASSIKPEPRHFPIPFLNELVQRHFRATSTATLSITGRHHELLYLLVATLIAPPQCKTVAIVDFDGRFDPLRLLATLPFSSTSTGAPTGTNTSTRPLEPSDLDHVHILRPPRRSNVPLSTYLAGIEEYMVYAPHKSREREWWGTIVVGGSNNNNPTTAAAPAAAAQAQIQAQAQVAVTAGWQGWLRVDRAEVTTATGTGAWTFRNKSAEEARREREGRQAAVEEGGWVASSAWGTFVFGSGSGSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIY2</accession>
    <name>A0AAE0JIY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_463102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683416.1">
        <property type="nucleotide sequence ID" value="XM_062826680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIY2"/>
    <dbReference type="GeneID" id="87863834"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3348334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="613" mass="68560" checksum="D8BB41F51BB74921" modified="2024-05-29" version="1">MDATRDKETTQLPHTPPYFFLTCALVVLLIQVFIFFDILPSLSLFIFILLLLELFHPYTHFLYPIPIMSKIFTQADVSSHNKPDSLWIVVDGDVYDVTKFADDHPGGKKILQRVGGKDASKQFWKYHNEGILKKYQPKLQIGSLDTKPKAAAPAPAAAPAPAPKAAPKPKAAAAASSSHEESEALEPFGQLIPFADPSWYQSYHSPYYNETHAALRAEIREWVETAIDPYVTEWDEKKEVPAEIYKEMGKRGYLAGLLGTKYQSNYVENPIKSVPAEKWDLFHEMLLTDELSRTGSGGFVWNVIGGFGIGCPPLVKFGKKSLVDRILPGILNGDKRICLAITEPDAGSDVANLTCEAKLSEDGKHYIVNGEKKWITNGIWSDYFTTAVRTGGPGMNGVSLLLIERDFPGVSTRRMDCQGVWSSGTTYITFEDVKVPVENLIGKENQGFRVIMTNFNHERIGIIIQCLRFSRVCYEESVKYANKRRTFGKKLIEHPVIRLKLAHMARQIEASYNWLENLIYQCEKMGETEAMLRLGGAIASLKAQATVTFEFCAREASQIFGGLSYSRGGQGGKVERLYRDVRAYAIPGGSEEIMLDLSIRQSLRVAKMTGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ72</accession>
    <name>A0AAE0JJ72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_393300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683698.1">
        <property type="nucleotide sequence ID" value="XM_062823758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ72"/>
    <dbReference type="GeneID" id="87860912"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="104" mass="11581" checksum="B5AE73B4F617B9B2" modified="2024-05-29" version="1" fragment="single">ELAHPNDRPTITSFFNPSWYTGAILSAGAVFATSSMQSEWSWRLPSALQALPSVLQLLAIHFCPESPRWLLSKDRVGDAFGVLSEYHGEGIRGNEFARIEYAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJI0</accession>
    <name>A0AAE0JJI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B0H65DRAFT_456132</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684150.1">
        <property type="nucleotide sequence ID" value="XM_062826274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJI0"/>
    <dbReference type="GeneID" id="87863428"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 21" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="24">
        <location>
            <begin position="285"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="654"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="934"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="985"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAK3350855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1160" mass="128550" checksum="872B167EF776EA11" modified="2024-05-29" version="1">MLTFGRTTEAPVLPPDHPLRTAFSRYGTWVARHVKTVLPMSVALVFLLLYPIFFLYTTDATNVTSGVSNLPHHVWTDAQPLSERAVAEPDVIMRSIWVHGSYMKALDREILLGALELQNTLLGPTTDFNPRRPHAPRILPDDPTVDMTRDQRDAFHVVNGLTDQSWFFHSPLQYWGGSADNIVADKDIIFTVNEKKTQSTSVNVTLRHSIVFSGKRFEERRLVAADALVITLIHLKDSPLGRQWVRNAERLAAQVHDKWTVIPHDGKSMASQLYEFQFRPMSWPDWFLLTIAYSLTLFYLLLSLSKLRAVKSRFGLMVTILAQIAASIGSSLTICAIFKIDLSRVPYYAYPLVVLAISMENSFRLINAVIITCSSISISDRIGEAFGQTAYVAVANRLQNLAILLGLSRITFPGVAAFCTFAAVAIAFDFLYLATFFLAVLSVDVRQRELYELEKASVRKTNAVDETTLLDRIRRIRHSGATVSTRVAGTIVILGFILLAQSHYALESGSQWLNWIITRSWRVAEPVISKSSLLVDIHQARSPTSWLRLQDHETAREVINVVKPWAHSYVARVYEPLIFVAKGADRIPHSPEPMFLPAVYDFIHNEIPRFVVFMLTLVALLLLLTNYLLQGNDKHAGDPDHPDNEPLLSVRSLSHGHDLDVVKMAVSPGNKLVSVGLDRNIQIWDVPLNSRTRVMSDSETPLENPFPVLAMAIDGDSKWLALLTWQRVLLWDTEEQQWGLSIEVELGGHKPEAVFFNYANKNLDSPSLVIVRKNGTMFELDLEGGASKEFTICKTPFAMALPFAELTTQNQLSQSLSILTLSRKSCIHIARQQAGGWTSKEVKITTGEAKDIHSIVPAPDLSMYLICRSRSVDLVDLESSAVIQTFNTELMEPRSLKLLLSSRGAPQHGLPPLSLCYISLETGDLVIQTFHRADEADPMHHPKDYAPEAPRQPWDEEKEVKKRIENPGRWEMLPNGGIVGVRRVPVASSSSSSRRRSFQAVSSGAGVGSGLRRRGGAAAAAAAAGSSTADATDATTPDIGTTRWEAWAFNNLESAKTKGIETQPLDQQADEEDTMYDNLLVSELGPMVRLGTASVAVGLGNVIKVISVGHEHFDKVVTRDRLTAENLRNQNFGRRRKTGVAAHRTRGGLGGCGAAPGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK40</accession>
    <name>A0AAE0JK40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucan 1, 4-alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_108282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684404.1">
        <property type="nucleotide sequence ID" value="XM_062820529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK40"/>
    <dbReference type="GeneID" id="87857683"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="92696" checksum="011C2BFC101DFE2B" modified="2024-05-29" version="1">MDDPWGSPWATTDAPTDHGHSLTRKKSDLEPPKRALLSASNSPRLPAITAPSPWADAEDGFGDWAAPDGLGTQTTTAAQSGWTGGWRSRSPSLAAPSRDNGFRSRSPSLVAPSRENSWRSRSPSLIAPSRDNGFRSRSPSIAASVRDEEFAKSNPIAWPDNIASSNSPIAPVLRQPSPDPWAAEYSHTPHNDGSIAPRLVINLPQSITEEEDDVDKGKLPELNPDWGDEEKDAPKDQANEEEKSEPTGAKAEEEAEVVQSVPIRVSVESTANSQPTRSTSPSGDDTDHGYERQDSPITSIDDDSRARPRLTRKPSGIVQELVDKFDGIAKARSQEPPVIRRAQSKSSLSPHPDISEEASDFGDFEDAQVKEPRKSQAPERPSTPEEVQKSSPQHGSPPMTSPAQSMGIHLGHMDELVTKFGALNFDIDLSNVDKLFDTSTNTKPLFPYADVSDHIITDSFNSISERKAWYRISRFGSSRKHNAGDDENYRRVAWPTATVCQETLQTVRRWMEEDSIAGRVSLGGGISKTQKNMFGWDSSAEPVTLDAIFGKRTVPTRPSSVQPLQPPSAFGHVDNSPLGNTTVNSLKHQPHRPASLELPPVATFSWSSDSPASAGQPPMTAPLPLTPSQPAPGPFKVTPMDLGMSSISATAAAEDNDDDWGEMVSSPSVMKSTVGGFPDFNAPVSTLTPTRGPTPGLPTTESMFQSNPDPVSVTPTPKAGTDTTVPVTSSAADPWASADFSFFESPSRQQTGPTKSSATPSRPSSMIAASFTQTVPGSSTHSFDLSRVTTPVSSASSVIAPYSSMTRNNSPIAAKGTTSSAISSPIARQMTPTQATGDLQQGEPTEGKVTVSSILGGLPDLSYMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK90</accession>
    <name>A0AAE0JK90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_110414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684492.1">
        <property type="nucleotide sequence ID" value="XM_062820566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK90"/>
    <dbReference type="GeneID" id="87857720"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000048">
        <property type="entry name" value="Free methionine-R-sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="176" mass="19145" checksum="27E9DD51EB0F1E97" modified="2024-05-29" version="1">MVHADASNFAADITKEEAYQQVLDQAEGLFYEQRNWVCNLSNCASLLWHAFKSLPAPSNQVNWAGFYTLNHPSTTELILGPFQGKVACQTIAFSRGVCGAAAATKTTQLVPDVDAFPGHIACDGDSKSEIVVPIVVDDKVVAIIDVDCAELNGFDQVDKVWLEKLADLVARSCDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKD1</accession>
    <name>A0AAE0JKD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_506691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684550.1">
        <property type="nucleotide sequence ID" value="XM_062828080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKD1"/>
    <dbReference type="GeneID" id="87865234"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="495" mass="54566" checksum="38EAA0C8EAB512EC" modified="2024-05-29" version="1">MFAKKLTTARHSRFWAEKRIIAISFFITLSYFQYGYDSAAIAGFQSMRGFLKIYGHVDPHTPIGYNISTNVQRLIQSLINIGSFMSAFAIYFLGSKISRRLGLWIGCALAFLSVSIMIGVENLGGLYAGRLLLGMSNGFLVPYNVMFVSESAPSLLRGPILGMTVLQTSLGALFGILVDNYTNGRESEDENAINAIRRLRGIKDETLLRAEVEDIRSAYEMEQELHAGIHLKGMFRGTDLRRTLLSYGCIIGGTCTGITFMAGFSVYLFMMAKVGKPFYWVMISLVIALTGNMLSFSAMRIWGRRQLIIYCSIGSAAMWLGMAIIYTVSGSHTATDNGAGAAKGLVALSIVYGWVAGFGQAGVLIALAAEIPSQRLRSQTVGTGAGINAFFGWMVSFFSPYFINSDKLNWTPKYGYIWGGSNLILAVWTWVFVPETKGRSLEQLDELFEKRVGARQFSSYVVERPLVDDVVASRAEGTNGKHREKEAPALTERTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLY1</accession>
    <name>A0AAE0JLY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-repeat protein pop3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_136890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685153.1">
        <property type="nucleotide sequence ID" value="XM_062820889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLY1"/>
    <dbReference type="GeneID" id="87858043"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="318" mass="35519" checksum="1069F027338EB519" modified="2024-05-29" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHPESQVNRLCISPDKRYLAAAGHRDVKLFDIRSTNPQALMTFQGHTGNVTGVAFHCEGKWMVTSSEDGTVKIWETRTGTIQRSYNHGSPANDVVIHPNQGEIISCDRAGSIRLWDLAENTCSHQLIPEEDVSVTSVTVASDGTLLCAANTAGNVFVWQLIQAYDRTQLIPLTHFSAHKESITRILLSPDVKKLATCSADHTARIWEVKEMEPATADSEPQAFPLEATLKEHQRWVWDCAFSADSAYLVTACSDHYARLWELHTQLVIRQYNGHHRGIVCVALNDYSEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM34</accession>
    <name>A0AAE0JM34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_1491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685515.1">
        <property type="nucleotide sequence ID" value="XM_062821053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM34"/>
    <dbReference type="GeneID" id="87858207"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="125" mass="14381" checksum="41A496D0DE61E971" modified="2024-05-29" version="1">MSSGKVKAGALWSKNKDELTKQLGELKTELGQLRIQKIVSSGTKLNKIHDLRKSIARVLTIINAKQRAQLRLFYKNKKYLPLDLRAKQTRAIRRRLSKEDASRTLEKTKKRATHFPLRKFAVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JME8</accession>
    <name>A0AAE0JME8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_415894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685662.1">
        <property type="nucleotide sequence ID" value="XM_062824008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JME8"/>
    <dbReference type="GeneID" id="87861162"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24645" checksum="97E2E3A109ABB494" modified="2024-05-29" version="1">MAKSDFDNANPTVLSVSQLPSRNLAKGHVRKGPDSKYDHILFPKQWWAGSSLNSDPSVWTSDEDEDDDLTLATEEPIDEQEIYGKNYAPSSCTCMERCNLLSTISDPEHPVTLGQIAVVRLDDIHLSPSPAERLDPNTLTNVEVDLTPTVNHCSLATVIGLAVRVRLENALPPNYRIIVRMKDGSHAQDDQVNKQLGDKERVAAALENDTLKGIIEKMLETCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN02</accession>
    <name>A0AAE0JN02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_7108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685661.1">
        <property type="nucleotide sequence ID" value="XM_062831309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN02"/>
    <dbReference type="GeneID" id="87868463"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="747"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="840" mass="94462" checksum="26F4A43C3CA0611B" modified="2024-05-29" version="1">MRACEGCRRRKIKCDAATTNTWPCSACIRLKLHCVRPNGFDGAAEPQVYEPPRAQFDSSPVQESYQQQQMALTDHQQLLTHTQAPKATPIYPPPTSFQDTAALYHTVPYTQPQAVPQNLQYAAVHSAYATPDSFPTPPSMHQVPQVSQLPQISQHPSSPEDYQSEYAQQDLADLLGSLKVNEAGTAPYLNSKMRSADDEEPSVEETEEDQFTKNLPPLTAGKIRIPPALMPSEDLCLHYFDLYFTHTHPYVPVLDKNQFYHQWHNNREAISPLILEAIFAIANRLADDAAQGQQWLYLATRHADSFLDVPRLSTLQASLILLKAREQAPKKGYYYRSWMSIVQCVTMAKDLGLDEHYADHQAGRSCGLSPAECQLRDRIWQTIFIVEIMIGTPQGKTDLAVEEETVNFEVPRPLPNGDTSEYHVSRNFVYFSKVVRNVCRMSRVYSRLKRNKEWGIDPEFVQIRPAMDAWLTDLPHDLQLDFPADGSPPWLPSSFVGNMHSYYHLSIILFHRPQLAHMTPTGTGSQWKQHMLVSYRAAKMLCRLQEGIINQFGIAGLQCMQRGINFTLYAVLACIVLHLVALTSPDPALNAESREYFTRHMRVLEKCMGAWPMPDMQRQIDSVREAFSQDIRKPFVLKPSFPYGSPSSNSHPSPSYRSDMSRTGSIDHQLDTHVQHSHVSYTTHPLSPPISVGPMDNKSDSHDLQSLAMMSSGHGTQAPSMAQTMPLADAPAWNPTRIFDQWNAQFGNPQVQHPSQLTNHASPLSLPSSGASETSIQDLQAAQAQLSPVSQQMPQYPTNPVQTFVTPAMWQESVASVYEGGLKRSWGGDYDGHMSVKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN27</accession>
    <name>A0AAE0JN27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_562743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685989.1">
        <property type="nucleotide sequence ID" value="XM_062830212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN27"/>
    <dbReference type="GeneID" id="87867366"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042249394" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22245" checksum="F62B30BF9D1C661E" modified="2024-05-29" version="1">MKHTFSAAFTALLLLILTACGTTAAPTKESTKKPFSFASWVDDLSRPDIVALTPEQALEAYNASRHSAVSKREGAGGVSKRWPEGLGMCFPSDMHAPADDAVAIIALFVEKGQEKVTLRQDPSGFRNVIGVHGQLTVDAYCYRGGRNQWMCPERTVTCLIVAQAVGHLMDSCTWDNSVGGSYWVLDRELFLNVWDGAFLSVENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN56</accession>
    <name>A0AAE0JN56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Translation initiation factor eIF 4e-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_19996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686039.1">
        <property type="nucleotide sequence ID" value="XM_062821767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN56"/>
    <dbReference type="GeneID" id="87858921"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="247" mass="27748" checksum="5A84BF1D332B187D" modified="2024-05-29" version="1">MSEQVDLTTIPISPEGGNTNGDAAVKDDKTVTVFHDKEHFNVKHPLSNRWTLWFTKPSSGKGDNWNDLLKEVITFETVEEFWGVYNNIAPVSELALKSDYHLFKEGVRPEWEDPQNKHGGKWSYQFKEKRSVNIDEIWLHTMLAAIGETLEDEEDGEVMGVVVNVRKAFFRVGVWTRTIGKHIPGRGDGDISGGKGRSPEKGKEILMAIGRRFKEVLQLPANEALEFSGHTESAHSGSSRARAKMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNS5</accession>
    <name>A0AAE0JNS5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_562851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686063.1">
        <property type="nucleotide sequence ID" value="XM_062830214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNS5"/>
    <dbReference type="GeneID" id="87867368"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="231"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="283" mass="30427" checksum="413B1B5A7D073DF8" modified="2024-05-29" version="1">MGAESSKVARKLPKNATAASIAAASRSGAGAAPRAPPPRVNGGQEASQSQMESASSDTYEVAAPPTQDHLHHHHQGQQQQPPTRTSATSSFQSPTGSGSPLDAIGDPAFAARLRQLSATVQPNPIHSPSSTVSVHPQPQLQSQNLPSSNKFQSQFPSRASFQSSQSPQQQQTPPSSPQKENIPTLLSPSFPSLRSNATLTALDARRELEQKYEEEMDKFGRNDKTFKGRQFLSVQMVKDVFELRRRGVGTEEIERRLGLARGVVRGMEGGGVVRAVDAFEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNU2</accession>
    <name>A0AAE0JNU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">B0H65DRAFT_449454</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNU2"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="104"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="319"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3354733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="491" mass="56051" checksum="1D72713BAD88F663" modified="2024-05-29" version="1">MTNIQTGPTTRGLSRFAIPAVCGLITFLGYYSQYLFNTSPDLAPGPLTRRESITLNTLLVCLWLTYYQACTVDPGRYKFPPKEKEEDNNNNDNHITRRGGGPQQNARWCKKCSAPKPTRAHHCRHCARCIPRMDHHCPWTGNCVSLQTFPHFLRFLVYTNAALVCFARLLWARLYYGLWDQRHVPAYLGPSVGALLGCTMLSIAWFATQFALTVLLVTTVRSWMLGKTMIEEWEAEKHEALLARSYDGDDYWGADGHGGFVPVKVEFPYDNGFWTNMAQAMGTNNFLRWFLPVGGGGPKISNDTPWKGTGWEYEENGFNDRVGMWPPPDPEKLRRERAGAGGKWPGARENLGTGKPEVEYYRSSEDMKAAFKRRQQEDLRRRQQRRQHSSEEDEIMAELEEDEGYEQRSRTRSPPQQGRTWMNSEGDTLWDYGVDVDEEESYGYPGQGVSESVPLVGTATGYDDDQGDEDEDVPLAELMRRRRVRSSEGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP20</accession>
    <name>A0AAE0JP20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter transmembrane region 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_36408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686487.1">
        <property type="nucleotide sequence ID" value="XM_062823681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP20"/>
    <dbReference type="GeneID" id="87860835"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="173"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="528"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="793"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="810"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="867" mass="97946" checksum="FE23F69462B49BBA" modified="2024-05-29" version="1">MAAQSTLRGSAAEEAIASFINKYTELIRSKLKTTTRTTRLLATLALATSIILSGEGTRRWWKRRREDREQGRKLVRTNSWLHNKDGSRTIYVPYKDGTSKVVIHSTKPLTFEAHRRLFLNPPRVSGLGDGHVPSAQTKPGLNLAFLHQFLSLMSIMVPRWKSKEAGLLVSHGIFLMLRTYLSLVVARLDGEIVRDLVAGNGKQFLLGIVKWCGLGGFASYVNATIKYLESKVSIAFRTRLTRYIHDLYLNDNLNYYKLSNLDGGVGQGADQFITQDLTLFCAAAANLYSSLGKPFVDICVFNYQLYRSLGPLALTGLLSNYFLTASILRRLSPPFGKLKAVEGRKEGDFRGLHARLIANAEEIAFYGGAEMEKTFLNREFKSLKNWMEGIYMLKIRYNILEDFILKYSWSAYGYLLSSLPVFLPAWGGLGGASEQQAEHAEKGGRERTRMKDFITNKRLMLSLADAGGRMMYSIKDLSELAGYTSRVYTLISTLHRAHADAYYVRGRENELYSLSDVQGTIQKGFDGVRLENVPIVAPALWPQGGEELLESLSMVVRRGEHLLISGPNGVGKSAIARVIAGLWPVYRGLVSRPKNNGEDGIMFLPQRPYLSIGTLRDQVIYPDGEADMREKRKNEYDLKRALDQARLGYLPEREGGWDTRKEWKDVLSGGEKQRLAIARLLYHEPQYAFIDEGTSAVSSDVEGLLYETCKEKGITLITISTRASLKKYHMYNLVLGMGERGDEWELQRIGTESEKMHVERELHDLRERLAQVEKWKARREEIEKELNKVWVEGGENLAPPPYAEKEAEGQATQTESENTLEQRSIGDSTVEIVRPEEETDQTEYEEANQGDHTETEAEYEDATETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP97</accession>
    <name>A0AAE0JP97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDP-alcohol phosphatidyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_30531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686333.1">
        <property type="nucleotide sequence ID" value="XM_062823207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP97"/>
    <dbReference type="GeneID" id="87860361"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000029">
        <property type="entry name" value="CDP-alcohol phosphatidyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="430" mass="48049" checksum="72C49D103FF55583" modified="2024-05-29" version="1">MKDSISAEKAAAECVSDDALIHLKTYKYSAVDKSPVSNYILKPYWNAFVEFLPLWVAPNMVTLIGFSFIVANVGLLLIFMPDLVGPGPSWLYFSFAFGLFAYQTMDNVDGKQARRTGTSSGLGELFDHGIDSLNCTLASLLETAAMGLGTTKAGVFTALCPCLPMWFSTWETYHTHTLYLGYINGPTEGILIACLLMAISGWYGPEIWSERLADNLHLFSFLGLNEENLGDTSFQDIWVYFLIGAMFVHIPFCIINVVNARLSRNEPLLPVFLEWTPMVVFTLSVGAWLYSPYSTLMDENHLVLFCVTMSFVFGRMTTKMILAHLTKQPFPYWTVMLWPLVGGAFIGNLPRFGLPAVTAQFEHLYLWAYLVFAFVVYSRWAWLVTTSICDFLGINCLTIPHEKQMANKQIAREIAAQTAAAVPVGPAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPC8</accession>
    <name>A0AAE0JPC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_42989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686682.1">
        <property type="nucleotide sequence ID" value="XM_062824850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPC8"/>
    <dbReference type="GeneID" id="87862004"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="206" mass="23128" checksum="49F95C1B144C0383" modified="2024-05-29" version="1">MPCGLGGSKNVQRKLVLLGDGASGKTSLLNVFTRGYFPTVYEPTVFENYVHDIFVDNVHIELSLWDTAGQEEFDRLRSLSYDDTDLIMLCYSVDSKDSLENVESKWQGEIAENCPGVKIVLVALKCDLREATEDEEDGANEDGAQREKKPMISYDQGLEVARRIKALRYLECSAMRNRGVNEAFTEAARVALSVKKDREESKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPE9</accession>
    <name>A0AAE0JPE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_505214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686649.1">
        <property type="nucleotide sequence ID" value="XM_062827973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPE9"/>
    <dbReference type="GeneID" id="87865127"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3355271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="135" mass="15411" checksum="1CB29DD99123F84C" modified="2024-05-29" version="1">MASDPMSVNSSAREPPAPPGSGADEEPKYGGYTRFELELEFVQALGNPLYLNHLASRKLLSNPAFIAYLDYLQYWSRPPYLKYITYPGPTFKNLQLLQQEKFRQDIISPDLVERLRVEGMKAGIDWHRESFPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPR5</accession>
    <name>A0AAE0JPR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_418072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686789.1">
        <property type="nucleotide sequence ID" value="XM_062824122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPR5"/>
    <dbReference type="GeneID" id="87861276"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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    </dbReference>
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    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="165"/>
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    </feature>
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        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
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            <end position="241"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="308"/>
        </location>
    </feature>
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            <end position="590"/>
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        </location>
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        </location>
    </feature>
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            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3355411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="629" mass="67000" checksum="6E48812E2582DB1F" modified="2024-05-29" version="1">MASAARGSRETPAVDSATLTQTSAAASDNGSSSDNTVQNNFNNSQAKEEQEKEQELERANENADPTAPPTDPPTAATGPGTGPSAAAPEEGRTNLETTAIILALASALFLAALDVTIVTVAIPTISEEFNSTTGYTWIGSAYLLANAATAPMWGKISDIWGRKPILLITVAVFWVGSLICALSKNMGMLLAARAIQGVGGGGIIILVNICISDLFSMRKRGIYFGVMGMVWALASAIGPILGGTFTSKVTWRWCFYINLPISGVGMAILAFVLKLHNPRTPIRQGLMAVDWLGSLTIVGGTLMVLLGLEFGGVSYPWKSATVICLIVFGVLMIGIFGLIEWKVAEYPVIPMRLFKRRASVASLLVCACQGFVFISGSYYLPLYFQAVLGATPLLSGVYVLAFAMSLSIVSAATGVYIKKTGKYLPPIIFGMTVMTLGFGLFIDLEPRPNWAKIIIFQIVAGIGVGPNFQAPLIALQTTVPGRDVAAATGTFGFIRQLSTSISVVVGGVVFQNRMEKQHERLVQQLGPENASLLTGGSAASNVGRLASLPPDQRQIARDAYFNALRTMYIVYVAFSGLGLFISLFVGSRTLSKEHEEHKTGLDNMKKAKEDAAVEGRRQTPEDEEKGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPS0</accession>
    <name>A0AAE0JPS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heparan-alpha-glucosaminide N-acetyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_50338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686892.1">
        <property type="nucleotide sequence ID" value="XM_062827873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPS0"/>
    <dbReference type="GeneID" id="87865027"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40407:SF1">
        <property type="entry name" value="HEPARAN-ALPHA-GLUCOSAMINIDE N-ACETYLTRANSFERASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40407">
        <property type="entry name" value="MEMBRANE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="98"/>
        </location>
    </feature>
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            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63412" checksum="BC92536933466907" modified="2024-05-29" version="1">MKTQDQNNNLPAQACQVDIPEQPDPAVQETSFAADACDASSDLQILDHEPIPDEEWHAQNGQSSALESQSNQHQHQHGSYSYGSFTHTLRSGHDGHHKSTARALAPDLLRGLLMVLMALDHNAMALQSWDHATAPQGENDSIPVHEWNRPIAHNIRVLTHLCAPGFTFLLGMGIVYFGRSRTNLGWSTARMAWHFFTRAVVLTLVMIVMSLGITLGDTWFLNIVLFALAVDYLLSGLIWLVAAKTEKMLAFIILKVLPEKKEDDATEPLLANRRGVEDIAPDRAIIRAADISWHIHNLVLSALAVVTIWWNIWLSPTNGHCGAEPVQKLPDTIWARIWFYQVFDTDWRIISVFPPLAWISFAILGLVAGRIILARSWSTKAITTGNLLAGIAFTIVFVGTRFLNAGNLSEGCLHMPEHAKPDAPDNQYLASWRSFIYLIKYPPDVAFWAFTMAGNLFLFAFFSVIPPRLATIVFDPLLVFGTSALFFFVGHLTLLFVLARPATHWFGHVLGHPDYWKPGQPAVGVDNLWVFFGVWLLVLAIMYPLCKWYGGFKRRRGPDSIFRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ89</accession>
    <name>A0AAE0JQ89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_55917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687084.1">
        <property type="nucleotide sequence ID" value="XM_062830122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ89"/>
    <dbReference type="GeneID" id="87867276"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="254" mass="27843" checksum="4DA3FCE7866187DF" modified="2024-05-29" version="1">MPSQRRMRAFLYIALAGFITLLFFTSRARHAQEPDARSIQDFYHKTKSAMEGTRIGGGSRRGQAVVGTEKIEIDEDDAIVAKAMQERLRKAEQMAKNNANAKAPNKPDAPEDIVGVGSSAHGQNHLDKGESSETEEHHAVLEELRSILKKSPIIIFSKSYCPFSKKAKNLLLNDYQIDPAPYVVELDQHALGPGIQAELGERTGRKTVPNILVGGISIGGSDDIAKLDQEETLIEKIMSLAGKRLTVTKHSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQI0</accession>
    <name>A0AAE0JQI0_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_555244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687297.1">
        <property type="nucleotide sequence ID" value="XM_062830019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQI0"/>
    <dbReference type="GeneID" id="87867173"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3355919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="844" mass="94409" checksum="A3C25FACF1D409C4" modified="2024-05-29" version="1">MAPGSLAGHDEGGVSPGRKLGKIMGKLGSRNPEKQTAICELSRPLTLIDLPHDILELILKEITDNSDLTALARTHSVLYDLVIAAIYSSFDIAWPDSNNSWSPNTPTVDALTSGLSTLCRNTHFSFAAITTGKPGRPARFGGNNYTEYVKKFSIENGPREWLENYLVTKVGGKMLNTLVASAVAKMTNLESFTWDMPTGVLSDTFMALASLSRWPNPEPSKLKSVWIRWHDTSGLSDHPSTSNHTPFPLLTVQAGSVMTPIGCRSPNHATYNGSKSPIGYSQCSYEYPTFSILPPLKSLTVLNIEEPAYLDEMATLIERSKDSLEELRVGLSLRAYRRDFFMAWDGSTLKQVDHNARWPGECTIGERRLGGVLGVLVGKIYDIRRRSPETKKHDTSMAGSGTQVSNSTTDPSAQRASVLQSPNQQYSTEALRSASENARSTKPDQGVAGLRDGKLKLRVLELERMALSMHVLRYAFDWSVLTSLTILCCLHQETVWVLLRRQFRPEPVNPDVETSSGTPSASPSTLRYKLSLKKIHTDLTTPALIEFIKETLAPDSLETLYLQDTRLNGPAPPVKLHKIFQAIEVHSSSLRALLLDSSGPTPRTNCSRWRYWSLTTNTLRYITSGRMVNLKQLSVSLYYSAWHPFLQSLPNMPQLHAIDIPHVAEYFYPTLHPNELALYIADILTLRPEVRLKYAGISHTCFEFWEHRRVITDRKWSVSEVDTSAAFLESWGNDVGSGEVDDDDGDDGDDDDSESSSSEEEDDEDEDEEGVITDDNELEEFHMDEDDDHLVHGASSDSEDSDEDSTREEDDGFYDPEGRVLIRVREIPFEEDKVEIFRARHMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQJ1</accession>
    <name>A0AAE0JQJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_385983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686572.1">
        <property type="nucleotide sequence ID" value="XM_062823710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQJ1"/>
    <dbReference type="GeneID" id="87860864"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="447" mass="43940" checksum="40D0479FEE4674FF" modified="2024-05-29" version="1" fragment="single">MALNLLPRMPSLSVLAAADNVCRIDLTVLFPDCASIEIGVPAEQPHSVDVQPSTIYVTVTPPTVTVPPRDDHPHGGPGGHPHWPVTATTTCDEEGLVTAMPIPTGRPPFGPGGPGGPGNVGPGSGGPGAGNNGPGNGNNGPGNGGPGGPGNNGPGNSGPGNGGPGNGNNGPGNGGPGNGNNGPGNGGPGGPGNNGPGNGNGGPNGPGSGNGPNPGRPSTTLATITRPALPTSTSTSCPLPPFLSISTTLTDMLDLDLKLYMDLSSLTSGVSSMLESVVPGLGEGLSNLMGANNLPASPSNPPTTQRSRFRTLPCGTSLGSLPGGNTTTVPINDDNTDGPDGNGNGNGNGNNGNNGNGSGSSAIEECIKRCEQDAITTSLELMNLRDCLGVTVDRKTTVDNCLYFVGPKGEKLPILDLGIVVDMTGLLGEDASGAEGVESAVKDGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQN7</accession>
    <name>A0AAE0JQN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_414808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687386.1">
        <property type="nucleotide sequence ID" value="XM_062823942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQN7"/>
    <dbReference type="GeneID" id="87861096"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="279"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3356009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="453" mass="50320" checksum="767325BFCC9D74CC" modified="2024-05-29" version="1">MTFKVIIVGGGPVGLYMAHAFERANIDYVILEQQDTVLNISGQLLFTWPQTVRLFDQIGLLADLEKVALGIHHKKRLFGDNGQVTTTSNFWDAMQDNHGYPFLPLLRSELVRILYAHLKGRESNIRVNSRVTDIRPHATGVHVHLADGSLITGSIVVGADGVHSRTRQIMDSLAAQHALNPARLANKPMVSTFYGIFGRASNLDLGIEPEVFFESRGGGGEPGGAVVQCLATKEIVQFVTLKPLPGGPTAERGPRYSEEEMDEYAASLADVAVCPSVKFGDVWAKVEKKSTRMLNQEEGFLDSWFFDRIVLVGDAVHKSTSVNGLGMTCGLHSGAVLANELHSLLFSEQHEKGEEDKEPSTEELEGAFKRYQEDRKTEVKPIWNGGHAMIREVVKKGWVSWFWDRFVLPWCDMETFAKGLLVSVLLVRQGQILRFVPFEGRGGRVPWARKVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR91</accession>
    <name>A0AAE0JR91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_50592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686902.1">
        <property type="nucleotide sequence ID" value="XM_062828029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR91"/>
    <dbReference type="GeneID" id="87865183"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="273" mass="30343" checksum="E0055EF05D9BF99B" modified="2024-05-29" version="1">MAMENDTSSGPSRKRLRTSHACDLCRSRKIRCDGNTPCAACFATENDCTYGSEANSWHIHHRRGKSDLILEGVLRLEKYLHELNANIAASPHLVNRSSSHPVLSPAVGSSVGRGSFSGGSLTDLRITPRLTLCPHPDELDNVNNLENAVLESRRTSTTESILQWPHFDVFPSLRNDYTSIFHLEQSRPRIRTKTAYIHPYMTEEEVDSILGAFEHAVNFWYPTTSRDQLQDARTMITNGNFDDDDGLRVCLALLTMALGCASKVTAGLMEGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRI0</accession>
    <name>A0AAE0JRI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_54501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687037.1">
        <property type="nucleotide sequence ID" value="XM_062829341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRI0"/>
    <dbReference type="GeneID" id="87866495"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="280" mass="31687" checksum="E0F9826BFEA0E7FE" modified="2024-05-29" version="1">MVEGEAKVLQYAGVVAQQPLASSIISPRIHTTTARSRFMRKLSANQLFVVPILFRLFAEVPRGNEPISHLGRSAPPLVLSSFPGALSLVYLSALLSIAQPCSLAKHLTCFAARFPSRQSTCMHFHRSRSRLRPFPCVEFTLPVKVHVQEHQARLKALKLPSLLYSYLMRSIPAINKPKDDRARRISKTTQPRSSLLWCVDSRDCDELYLCVGIRMWAIQDTPISANWGLRECVLRGLSFPDPSHDRCLFGRSSVLIKNRQLRPVAQFLKHHLSPLTICRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJ19</accession>
    <name>A0AAE0MJ19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_437427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676458.1">
        <property type="nucleotide sequence ID" value="XM_062825309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJ19"/>
    <dbReference type="GeneID" id="87862463"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="69" mass="7530" checksum="772561945B5952E4" modified="2024-05-29" version="1" fragment="single">PKAPRMASVAHGSCTPLCTLSGYVYWRQNRGSQTLLDGWLSFSSPSDGHSTPVSFSQLDCFQTQGHRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJ57</accession>
    <name>A0AAE0MJ57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_566651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676578.1">
        <property type="nucleotide sequence ID" value="XM_062830331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJ57"/>
    <dbReference type="GeneID" id="87867485"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF322">
        <property type="entry name" value="HELICASE MOV-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="391"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="662"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1025" mass="114212" checksum="702A8C0BA3DB34DE" modified="2024-05-29" version="1">MSFFTLPPKQSKALRIVNPETGQDTLPVPTPKPTTPTNIVGQTVTAKFKDGAPNPKKSAKAKAKLAEVLWVPPPPGDTPPAFDADEQYARGFDVYAPPFVPAALKQINEYAGTAVDTFPKTLIDYLQYISGILPTSLLPALPRPKFADNPSLQNLSPQCYAKYFRSLIEVELGYQRKENASYSLYGHTGILKFNDPNEPTVTITVPGLRENTPNVEVDDEVQLRQLRFDYGGHLESNLFPWTGYIYNARVSAVVRATETLVLRVGGITYHTAEVVTPTMIPPWPTEFLVKFNIVFFVPMVRYTPMIDVLPHVTESLDLAEHFLKNDFDALDSFIDEVTRNGSKRPNPDALSTTNVYWKQSMLFPTEADCSSQTNMVNWLEHYNGSRFDESLNYEQRIAVDSVICQNYGTMPYLISGPPGTGKTKTMIEIALQLVRNVPDVSHILVCAPSEPASDTLADRLSKSMNRNELLRLNRPTRDSREVLTTLLPYCYMQNDVFALPPFAQLMSYRIIVTSCRDASMLMYARLTNSDLYTVSSTLHQQIHPTLPPPTKARLHWGALLIDEAAQAMEPEALTPLHVVSPPLKGPEPLFTPLVIMAGDEQQLNPRTSCPSTPLQQSLFARLFKRPVYANHPLARRLAKDAQPPKQQYQLHPDLLPILRPPFTNLIRNYRSHPAILAMPSKLFYFDTLVAEADTHERNRLSSWSGWRGRRWPILFHDNPSPDDLEAPSPDSPSSTATTGGWFNVGEAHLACQYALSLFRSGLVKQREICIMSPFKAQVRLIRSLIRGEQYGMMWEVNVGPTEAFQGLEHGVVILCVTRSRKRFVERDRGLGWGVLPGGVKRGGKGEQERVGGGIRNKLNVALTRAKFGLIVLGSREVMMGDAEKEEEDSDEEEDDDDDDESRGEEDTGGEEEEGGKKKAKKEKGTSSTQGTRGEEGTEWAQIIAFCERNGCIADSNPLSGSPQRSQTQNGEGWRGELTKWETDILLSNPHGGRGSHYRHGGNTFTSDVTSASASRTGECSDVDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJE8</accession>
    <name>A0AAE0MJE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_81931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676566.1">
        <property type="nucleotide sequence ID" value="XM_062831455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJE8"/>
    <dbReference type="GeneID" id="87868609"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="65347" checksum="F41421E7E2D8755B" modified="2024-05-29" version="1">MGDETTNYPMVKLTPPSQFLAPCPKFRVLVLGNPESTKQELFSRVFGVDLEKKLVSEAFSPTHDINVPLDLQGQNNHLEIFSSPNFFGPTTSTSFSSPFDSSLESDPSYTLASQTLRTVSQFISSHTSLSQIESVAPDVITSDTRLHCIWYCVSAADPSRPISPVEEYFFHHLSQIVPLHVPVLLLFTKYDEFVSQVQLDWIRSAQEKGMSKVAVAHILRDLVAKRFEDTIGRKWGEVLRGVDSGIEEKKRDKRRDSGFGFGYGGSDREVVLHVKGEEENASKREVVRVLVGGGGESEQDWGGEPAWGEELAGVEGGGYGELVKRTLEGLRESKEVRRAFAAAQRCLAGVSSEFAAELASTYFAVDTGHARKLHGVDVRDIMPNFYAKAVQLFNLRDVSSVLDDPTLLIRILEATFGMHQRILVDESLSHSSTEPSIFLGLSPHERAVMLAQAMAAVILFLHKLADVQWPHRDNLRGILPPATITARDVQRVIHEIEVGTEKRELLEEIESSPVFTSCRMRKEVADLIHRAVEKADKGAASHFTREERARGVLMVDDSDLQEISLAFVNDKGQDDMVLPNGLRILPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJG7</accession>
    <name>A0AAE0MJG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_553802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676626.1">
        <property type="nucleotide sequence ID" value="XM_062829991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJG7"/>
    <dbReference type="GeneID" id="87867145"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="179"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="373" mass="42409" checksum="75A33EC9F2520614" modified="2024-05-29" version="1">MEKRREEKQSKSRRSKKEKVREQRHKSKTSPTPICLPDKTRLEALPESDRQRIINQWFTYFKKRQLEFLESIRRKEVRDQKIMHMVRRGKIDIDPVSGLGNFDIDTILEDEDAIDTPFTKDHESNGRSPAQEEARLAEQDSLNASDDIAHLQDAFAAVIRIWETSEDRRDFETLLDQIELLSPINKVVCLGLGSCLSSFRCCSLFRECPYDDKEFPEPCKIANLCQHAMAMTTAQYFEARGKPGAGTVEVFVSDPAYDKVESQGLESLGFTVLEAEDALAFSKIDSNTFLFDLSNIGCIRDTWATCTSPALILCNFVHSTGVEMDSSGMTRDDTKAVRVSLTKKHARNETTRSSKLVLNVIESRIDSNPQIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMW7</accession>
    <name>A0AAE0MMW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_435638</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677451.1">
        <property type="nucleotide sequence ID" value="XM_062825203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMW7"/>
    <dbReference type="GeneID" id="87862357"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="316"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="574"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3338000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="665" mass="73800" checksum="72B221D25F16B654" modified="2024-05-29" version="1">MSWKLTKKLKETHLGPLASTFSRSPSTSTITDKEDKSQAGSSGTATPSNENTIGRRSARLVHSAITRLTSFPFTAASEALTQAPIIKPPKPGILVVTLHEGSGFSLPEQYRNVFSSGHGGNSMSTGSALNVAGSIRTNNSSRTANFLSGSSRPQSSGGFGAIPTNHGRISTKYMPYALIDFDKVQVFVNSVEGNPENPLWAGSNTQYKFDVSRVTELAVHLYIRNPNAAPGSGRSQDIFLGVVRINPRFEEKQQFVEDPKASKKDREKAAAEFANNQRALGHSGVEWVDVQYGTGKLKIGVEYVENRAGKLKIEDFELLKVVGKGSFGKVMQVRKKDTNRIYALKTIRKAHIISRSEVAHTLAERSVLAQINNPFIVPLKFTFQSPEKLYFVLAFVNGGELFHHLQKEQRFDVNRSRFYTAELLCALECLHGFNVIYRDLKPENILLDYQGHIALCDFGLCKLDMKDEDRTNTFCGTPEYLAPELLMGNGYNKTVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILSEPLHFPGPEVVPPAAKDLLTKLLNRDPQQRLGANGAAEIKAHPFFHAIDWRKLLQRKYEPAFKPNVVDALDTANFDPEFTSELPQDSYVEGPILSETMQNQFTGFSYNRPIAGLGDAGGSVKDPSFASSLADNSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN32</accession>
    <name>A0AAE0MN32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_592460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678003.1">
        <property type="nucleotide sequence ID" value="XM_062831126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN32"/>
    <dbReference type="GeneID" id="87868280"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3338552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="452" mass="51504" checksum="EE47147BCF3DCAAD" modified="2024-05-29" version="1">MPVLKPLSGNPEAPKQYNQPSRKGKKAWRKNVDVTEVEQGLEELNAQIIKGGVIAEKASEELFAIDVKPDTEITKKLPKHLKKPLKADEILAQRSAVPAVSLKKRPASETSGKVTDGVLPSKRLRATYVTQKELSRLKRVADGHHTTTVEVVDATFDAWADPEEEKKKKQAEETFNFLPKAEKPKAPKTLTQQPISLAATGKQLPAVPKPKGDKSYNPAFTDYSERYQEELRKAEEAEKKRLEELEKERLKAEAAAKSRAEAEAAEKRAELSEWEDDSAWEGAESDAEGLSKKKQKRPERKTQAQRNKIKRRKAEEQRLKHEAAIKKREAEAARVKQIAKELAEKERQLALQKAESNPNEDDDASVEEDDDVELRRRQLGKFKLPEKDLELVLPDELQDSLRLLKPEGNLLKDRYRNMLLRGKVEARRHIPFKKQAKTKVTEKWTFKDFTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNN2</accession>
    <name>A0AAE0MNN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_298010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678722.1">
        <property type="nucleotide sequence ID" value="XM_062823113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNN2"/>
    <dbReference type="GeneID" id="87860267"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="100"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="252"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3339362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="298" mass="33512" checksum="F2F39D8A45C664A5" modified="2024-05-29" version="1">MRTICRRLFSVSAVTLCPKRLNPRIATFTTKTMALHPAQDGAKLIFAPAGTLADPSVPGQAAQFLKAETRGGLRRSDLDPESPIAQFHTWFTDASQPETGISHPETCTLSTAQLPSGRVSARMVYLKELDPKGFVIYSNFGTSGKARDLFGSEDGSSTGNPWASLVFWWEPLERQVRVEGRAERLTTEESQAYFDTRVRGSRLGAWSSKQSAVLLPDPANPDDDGRTQLEKWVKESEQRFEGEENIPVPEFWGGLRIVPERVEFWQGRQNRLHDRFVYDRVRQDGGGEDKWTLERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPX4</accession>
    <name>A0AAE0MPX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-xylanase</fullName>
            <ecNumber evidence="11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_551449</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679997.1">
        <property type="nucleotide sequence ID" value="XM_062829810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPX4"/>
    <dbReference type="GeneID" id="87866964"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042017782" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="67"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3341055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="390" mass="43114" checksum="9C1674B95B3D7BEE" modified="2024-05-29" version="1">MQTKSLLLSLFALASAVPLASAGNNDNGNGNDNGKGSGKSCSHKGLDWYAKKAGLKYFGAATDSPGQRERAGYESAYAQYDEIMWKSGEFGQTTPTNGQKWLFTEPTRNTFNFTEGDIVASLARQNNKLLRCHALVWHSQLAPWVDSSSTDWTKDELRSVIKTHVTNVMNHYKGQCYAWDVVNEAFNEDGTYRESVFYNVLGEEFIQLAFETAAKQDPKAKLYYNDYNLESPSPKTEAVRKMVRGLQSKKIRIDGVGLQAHLVAESRPTLDEHVAAIKGFTELGVEVALTELDVRLQTPANATNLAQQKEAYKNAVGACVQVDGCIGVTIWDFYDPFSWVPAVFAGEGAALLWYDDFSKHPAYDGVVEALTNKTQGHNGNDPRGAKRWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ28</accession>
    <name>A0AAE0MQ28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_473477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062827210.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87864364"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042146211" evidence="1">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="145" mass="16220" checksum="54335350A8AC0367" modified="2024-05-29" version="1">MAWILLFHYTLLHTGSPMTYIASGKHHRVPIPSPLFSSMMNKGIHSQTSTPLQTSTPLQTSMPNDEDIGLITPNDKNKLTALPSRLNLFSFISVLGLFRLSCNQAFAQQDRGVCLHSLGVSQPQTKMLFSMSNDQLRVMFELSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_468599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680343.1">
        <property type="nucleotide sequence ID" value="XM_062826966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQA2"/>
    <dbReference type="GeneID" id="87864120"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="189" mass="21590" checksum="9EF9C43E3E1A86AA" modified="2024-05-29" version="1">MSRSSCFPFFFTCWFTCTTRSPSSGSSSRVTILIVSDQHSGPPEKSHHQLASRPFIAALLDITIPRWRSRLPMRHSSDRLDGFERYWQCWEHIKDGNKVYPMISPHPNHSAKRCSAASVRKRIFDRDISTTLDSPRYAEFESTVSFLVYSHLVQMQADEVLVRFVLGGPNSNKLYKPQLTTLCQDCTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MQD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_509730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680478.1">
        <property type="nucleotide sequence ID" value="XM_062828341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQD8"/>
    <dbReference type="GeneID" id="87865495"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="220" mass="24210" checksum="25D9D66D33A19384" modified="2024-05-29" version="1">MAESSSETLRPKIPCTCFRASKCSLRCYARLPTLSNPPSSRISYSDRCRLKQHIRITFDNLHGFFLSTITPTSYFRNSGPPSLSIPSTSSTATTSADITNPPATQDLPSASSAITDQTLQTLHSILSRAHSRKQTLNSLTSSEDTSTEDTSTNTSTNKPKIPLSTFTALYTSLITDHELFLTDLAPYYREEWAEGEVKKLMAEFVGETGSTASSYVCDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR56</accession>
    <name>A0AAE0MR56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_557763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681258.1">
        <property type="nucleotide sequence ID" value="XM_062830084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR56"/>
    <dbReference type="GeneID" id="87867238"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="60"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="674" mass="76417" checksum="86B6D1537F5AD37C" modified="2024-05-29" version="1">MADSTQTDAMLTGSLFSYDSVPLSDPSTQIRLIDLHPASSYTDDLYCYIYTAPISQAPSYIALSYISVVNEVNDGRAFIPLPLTSSLDTCLRHLRELQRRWQLEPLPLWIDQICINQEDNEEKSFQVMLMKDIYSSAHQVIVWLGPAADGSDKVMDAFAEIGQEFLDKIGDHTSEEHLLSVGRLIEENIEQPGVVAFLSKAFKVFLGLKRERSFTRWVERSWFTRVWTIQEFCLCSDTVFACGYEVVPERFISAVVDFTRCIVLDRCLRERLETPDTPTYSNLASGFVKLHKLFQHRGHSQYLDRKETLEHLLAEVFVGSTPSYVTNKRDKVYGLLGLAGDADELGIRPDYSTSTTIAQVLTQTARAIIEKKWKTQRIRGLYIIRYGSLGRRNSAQSGEAMSSSTKNEMELPSWVPEWNSKTIKTYVATTSYSACGKFRIADLVPTSSPTILGVRGFYVDTIVDLGEQAQVNRLHCPDGPKKILAFFDSVKRLLNMSKQNKCAKNIYATTTHHDAALWRVPIGDQYIAYGVGHQPYKRTDSKLESLYRKFVAYYEDWASREDDWNDYMAAYKAGDKQANLAMEMHMDELLAEGYYLALGNMRCKRPYLTKNGYLGMGPGHSQPGDKVVVFHGDVIPYVVRPGDNTYLLMGEAYCDGIMDGELADTAEREDFYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR69</accession>
    <name>A0AAE0MR69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_470492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680916.1">
        <property type="nucleotide sequence ID" value="XM_062827044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR69"/>
    <dbReference type="GeneID" id="87864198"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3343123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="446" mass="49239" checksum="98DD2FF941CE1D23" modified="2024-05-29" version="1">MPRRTSHLMGPSDVVILVVGMTGSGKSQFVSKLTGEDAGVGHNLTSCTISLDLYSCVENGQRIFVADTPGFNDTQLSDVEILKDIAFFLGQLHLRNVRLGGILYLQPITDNRVSGSALKTFNILRALCGPQALKCAALVTTKWDALRSSKDDLAAYDRENELKYTSNLWGSMRQHGSQSYRWLGSEASARSIVREVIQTSFRNTSSPVLQIQRELVDEKRPLDSTSAGCEIMKHYGDRCQKLKQELDNLRSELLSASDLTREELKEGEAEVNRLMDELNRAETSQQRLRVSQQDLFDQKKSEYEKLYQGIWEEVEQEKKMISDIDNRLSAFEQRLSRLEPKMDSAKGLATAEFPAAGTWARVRLFLKRNVLPLLGVLAGVGVVAAGAAVINPPLIMAGAQLFALSFSGVQWQHGQGADGRDLIAGVEGVMKACPPTPISAGFRICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRS8</accession>
    <name>A0AAE0MRS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF423-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_510225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681139.1">
        <property type="nucleotide sequence ID" value="XM_062828377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRS8"/>
    <dbReference type="GeneID" id="87865531"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3343346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="158" mass="16726" checksum="E626A0E523F4C256" modified="2024-05-29" version="1">MSANQAHHDPESEPASETTTLLPTDSPQQNTPKMSSTLFWRVGAIYGAAAVGLGAFGAHGLKKRISDPNKIASWSTAAHYQLVHSAVVLLASHHPVASALFTAGMTMFSGSIYALTLDTERFRFLGPVTPVGGLFLIAGWLALAFASKGSAVARFPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSE5</accession>
    <name>A0AAE0MSE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_246387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681140.1">
        <property type="nucleotide sequence ID" value="XM_062822404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSE5"/>
    <dbReference type="GeneID" id="87859558"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3343347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="327" mass="35669" checksum="743B6A7E327EBCDC" modified="2024-05-29" version="1">MPSETPIQNVTLVGASGNLGSVLLSHLLKTNLHITILQRASSKSTYLPHPNLTVTTVPSWSLPDVTEALRGQHAVIAAFPLRDLQAHLTLAEAAYASGTVARFIPADYGSVDARSQRARDLVPLFGKKVQVRELLEKLSENSAGRLSWTSLVNGHFFDWGLTNGFLHFYPFENPPRAHILGSGDEKSSQATLAQVSKAVVSILTGDAGHLEQTKNKVLMLQSFLVSQNDAVDMLEKVTGKKFEREYVNTEDYIKERKKVADEGGEGAGDAIEDLVFALGVVEGDWTKKEEYSMGLLGLEEEEDLEAVVRKALEESEEGRKLLAGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSM5</accession>
    <name>A0AAE0MSM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_507815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682893.1">
        <property type="nucleotide sequence ID" value="XM_062828172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSM5"/>
    <dbReference type="GeneID" id="87865326"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="643" mass="73383" checksum="92EDA78C5FB193F1" modified="2024-05-29" version="1">MPRFKPTSAARARFSAPLDAVNLQTLKSGFSGQVERERMSRLRSKIQEVRNAWLDNDTYAQLVEAVRRWCKPERLPEEVREPLERLLSGYRDYADVSISRPSNAHATRSSEQYDALEMYCSIPGYDYLFKLVSDTLRTEFLTIDLYNLRLSQLGDPRYGNFEGLTHRGMPVYQETVRFYEDIMRNPDLTMRSFAIPLALTSTSADPRVMEDFATKKSPGNERLVHMHLQVHTRGIDEGLLWAYRKRYPDSVVTSICAMPVANISPEGEREILLRGAFFQLLSVTTKQSGGDGVPVVQVIVVTMNSNRDHSTESSSNVDEKRVQREIFRRLVDASKYRACAELAAEFSPADVQGYKMLADKMLNEIRDMQELDLEEFDEASAGALGLEKEDVAVWLGGRLYALRRKQWHQALTKKDWVGALKTLNKEYSWRQCDWYNTGPLDAEGDGLSALHIIASSRPPEDKYSEEHRAWEELVEGAQADPRVWKTLKSFEERAKTARETSYNQELAEAFKPEILHHVEERRLAHLEEQLHRLMKDTAGSLVDPSRFRIPQLSCLTEMEDPRLWIPIPHMYGGFMVELLRSEEALRVTTIETIAGQTAPQSTIRVLESTPMSFGALEVENLVTEDIAKLTVQLTVIPVSEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSP4</accession>
    <name>A0AAE0MSP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_423460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682953.1">
        <property type="nucleotide sequence ID" value="XM_062824457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSP4"/>
    <dbReference type="GeneID" id="87861611"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="403" mass="46596" checksum="E7CB7A085978E53C" modified="2024-05-29" version="1">MPPKKKKPQVVPMPLFSRLPAEIQIMIFHEALRKPQIHFVKVTRDQSPRFMDNDRFWSVILKPRDKSADTSGYRLFDNIQDIALFSPIAAEVIRKNTLKVHRLPISKDGSWMIDAATDLVVLEFDPDKSGSRVRLWHPRNRVYNSTLDVTAIRQQLEGIRKRKHTSRNFCPEELLGLIYQLSHIEAVYFILKHRVNVKAVIDYAASYFSVPSATRNTFGFKTFYSTTRSYITVPLPSYEIGPVFHATWKAKDCIWPEDSPPALVSAAREATMALPPDSRERQYVKHMRKLSYLGRALDHREEVWPLVAEMIRQMRADQDTHFSPDWPHPIPPQANTARFRAYREHHRLQYNLDNLTKERRDNLEFGMLLMVDETAGCQNGKDKDVKCKAGGVNKKTKDGKSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSR3</accession>
    <name>A0AAE0MSR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_558412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682144.1">
        <property type="nucleotide sequence ID" value="XM_062830101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSR3"/>
    <dbReference type="GeneID" id="87867255"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="60404" checksum="F744323E0E62AA43" modified="2024-05-29" version="1">MDPQLPSPPQRLYLASLPNEILDRIFSLLPVPTARLCRLISHRFLPSATRASFPVLVVSPLLSDGDHLQRLANSPDIAPCLRSIYYVTDTLAEPRWRQFTWNTTDHPRNWLPHYVNHPEGSGRIDLHSPEWYRYRYPPLISHHRRSAEQIALDRERYEEILLDQAKFLAVDHSPNRDYDGIVMCLEQFPALESITLAACREMSLAAPLNSVALHSDRNPFRFRTEERVLRSLVRYLEMQSVMGKTARLKTLRIKNLSWCVLDDDPAGLFFTPTVEDALANLTTLEIQIRHGNPIHVAASECIPPKSQRRLSDIMSSGRVRSFLKSLTNLRHLTFERDRVWYRDDEMIPDDGWYKWSLGDIIDPEFRWPHLQSLSLSHFHDCEREDVERIMDNHADTLWKVSLGDANLRTTSWVNLVDYFYQENQKRIAGYSDKPLYHLELWGCLRGTREKSITGNQRPDAPDHTGEGERWVFWRGETHSWELARYVYGIAFQVSNYAREHRALYARILVGEREEGLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSZ8</accession>
    <name>A0AAE0MSZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_507715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682761.1">
        <property type="nucleotide sequence ID" value="XM_062828163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSZ8"/>
    <dbReference type="GeneID" id="87865317"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="309" mass="35637" checksum="3B4A14D208FF1BE5" modified="2024-05-29" version="1">MERQPRPALRLQIPPQPHLRPPNTDSSTGSFIVRLHVPRQPRPADDGPRAPPSISPFVFANGMLPPRPHDIGSMDIYVRPGEPRDLPHLLKIQPASTQNLRTSVNLRTWLRWRARHTTYGEVHLRNCLRDGKLWVAVAELATGENWIVGFATGIPQDRWNREGPRDNVLYFTIHVHVSVRRMGVGSQLLKQIEQDMWERGFDYLVASAFMQEPWKEPEETFLKKNDFQRLNTLGWRNGMCPLPLIMATLLILNKQYSEIQPGMQRTLWIKDLPPRPGSKRYGDVTPPSDESTPESYEWPSLRRLLAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTD7</accession>
    <name>A0AAE0MTD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_494581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682130.1">
        <property type="nucleotide sequence ID" value="XM_062827777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTD7"/>
    <dbReference type="GeneID" id="87864931"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="307"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="551" mass="61145" checksum="24536F1144933E0B" modified="2024-05-29" version="1">MAAAKNGQGMLYVTMQPQEGLSLDQFHEWYNNEHGPTRLRLPQIFSNGLRYQATDGQQPHFLAAYDVTDMAHLLTPTYLDLRANRSSREAETIGQVKVDRFFFDLVWTQEASSFKPAEQCTNAEAEGRVLVAVDVSLSLANEPDAAAEKVIQWYEEEHIPMLSKIPGWLRSRVLRTPSSIEGSNAGETKIITLHEYAPQNGLGGPEHKASMDTPWRTEVFDKYITEKGRRTYSLFYVFGPAPRDLEHLSRLPASKAFSAAAPRLTTTAGSEGPIISSYITTPHDGLTIPYQLEGNPSPTAPVIAFSNSLLTSLHMWDHLVKLLKQARPDLRILRYDTRGRHAISSPPQPATLDLLADDLASLLDALRIDKLQTLVGVSMGGATTLNFAIRHPSRLGKFVACDFNAASSEANTQAWKDRIAVAESDEGKGLKEKLAAVTVERWFHPNTMEKKRETVEWMTEMVAGNDVEGFRWSCQALWGYDLREKMKGVKEVEGLFVVGDGDGKGALVKAMEGFRGLLGDKGGELKVVKEAGHLPMCESPEGFWEAVRDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTY6</accession>
    <name>A0AAE0MTY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_423266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683449.1">
        <property type="nucleotide sequence ID" value="XM_062824444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTY6"/>
    <dbReference type="GeneID" id="87861598"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1162" mass="120714" checksum="16000FB3E5D76FD7" modified="2024-05-29" version="1">MSSSRSSSSSFSSSSSPLASRSPDDGTSSSTPPVRPRVGSSGNATRDDGSRSSSRIPVPVRLRARAGTTRTRPGQLVSSPSGFLEPVPEEPLDDGNIEGADSGKDASSDASLPDTLHETTNAALDSFFGVDDEEDQEQHLEEVVSGLSPSSSLQTSMQGPATALAPTQQQEQQPQQRRGPSGHQSAWGPGHRRKAAVSSFARVGDSSSFGARVNAEEGVRGMMETHARVADESVLGQVADDKATEDVPRVKAAPAATVEVSYESRAKTDPTGGLVARESAADDKVADELQRAVSSVATPPGSQLDSMPGPVRIRTTTAGGQNFGADAAVGTRSRSTTTVAGERPPEATASRPLPPPVPRLDPARLTAMSLSEKRRIKAERAQGCSHGLNSPRTTPDFAPLSLPAVTGLSGSVVEDIPPVPPLPANLSPSVVPAGSRVGLPLYTGRFAARPGPPPPNRPLPPIPGQSTVPLGTQVQAGEVGGDVEYEGDVEESDYEDSDSRESHHGGSRPRLYAPSLSTIRDSSPVPPASSVAVASSMSSSSPGTADRSFIASDDGSFLPRGDYDTGVAQRHREESPAHFRGSDDTTLVAADITFVQSDRRRWGMVPHMLGEEVRLRLASSPTPSSADSERTARPAPGEEQEECVEEAGFAIDNSAIVNDFGESVPSREESPTIPGSLVEDPAHGLTTTLPPLLADLEPLPLRRAPAVRRGSPVITSPRPQPQPARPALYVFPRPPMGLGLRPDGGSSTQRPGAASTSGDGGLVSSVTVGVLPRPPHVAMAMSSGAGSVVSGPGGAIPPGTVSSGVASPGVSSSGAGLGRGLPRSVTQAIPPPPPVPVSSPPRGFARSVTQALPRIGGALGGNSRFGTRAVSAPRPMGAPTGDEDDLDAELRQILSRTRDGYQDQRAVLRPGLRLRTQTLGTFGPSTISGSTPDITSPPTSSGRGSGSRQLSGSSTFVGSPTSPAMMSSPTPMTPGFSSPSFASGSGGRGRGRGRSSRGSGSSARSSQPQPPPQPRPQPQLAVEMRERGPALVTVRDDAEAERSSNEPEEEPRSHWSSDTEDEPSAMGRMRNAFSRLRTKSRGNLRREASSSFSTTTSLSPVSTRDGPPRLPDIPPVPPLPSIPVPPIPTEDDNDAANQAGSQRRKLNKKKSPANLFGKKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU26</accession>
    <name>A0AAE0MU26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_155302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682850.1">
        <property type="nucleotide sequence ID" value="XM_062821143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU26"/>
    <dbReference type="GeneID" id="87858297"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="712"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3347768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="750" mass="81546" checksum="A763A7DB962BFCD0" modified="2024-05-29" version="1">MSAMNRIRGAFAPPRKGETFELRAGLVSQYAYERKEAIQKTIMAMTLGKDVSALFPDVLKNIATSDLDQKKLVYLYLMNYAKSHPDLCILAVNTFVQDSEDPNPLIRALAIRTMGCIRVDKMIDYMEEPLRKTLRDESPYVRKTAAICVAKLFDLNPTMCIENGFLETLQEMIGDPNPMVVANSVQALSEIHETAPETRALVLTPATLKKLLMALNECTEWGRVTILTTLAEYRASDAKESEHICERVAPQFQHVNPSVVLAAVKVVFTHMKALNPKIVGAYLKKMAPPLVTLIASAPEVQYVALRNIDLLLQANPDILSKELRVFFCKYNDPPYVKLQKLEIMVRIANDKNFDQLLSELKEYALEVDMDFVRRAVKAIGQVAIKIEAASEKCVNALLDLISTKVNYVVQEVIVVIKDILRKYPGYEGVIPTLCKYIDELDEPNARGALIWIVGEYAEKINNADEILEGFVEGFLEEFTQTQLQILTAVVKLFLKKPSNTQGLVQKVLQQATADNDNPDIRDRAYIYWRLLSGDLDVAKSIILSQKPAITTTVTSLPPVLLEQLLSELSTLASVYHKPPESFVGKGRFGADEIQRAAIQEQRQNAAENPIAASVAAAAKGGQQNNIENLLDIDFDGGAPASAEHGGGVGTPDRFASPANVGGLPGAPPQPSGGMADIMGLFDAPPPMPAAAAAAAAPAAAGGMGDMMSSFAGMDLSGTSAPPPPGQQLGHTTSQTPPKSGGGSEDLLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUE6</accession>
    <name>A0AAE0MUE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_94957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683944.1">
        <property type="nucleotide sequence ID" value="XM_062831598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUE6"/>
    <dbReference type="GeneID" id="87868752"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="205" mass="22621" checksum="A99E2D8E820BC720" modified="2024-05-29" version="1">MHSLDPLVCFPRHTFNSRIGSLGMFVSQGSHHGTGPQLDKTTTGDIARNVRNSGEKASKHLIVGSTSGLWNGIIKALEDGIVRNGFLLQKSTARNKLPRGRDSLQLHCRAPKKVLPILQRATSCPEPHQEIIENGRSRPLLDRRKKCPDSSTAFLNYGEISTRLSSSDVSEVVDRYRHPRPGPPDDNTPNCTSDDDDDDDDDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUL4</accession>
    <name>A0AAE0MUL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Triose-phosphate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_128600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684933.1">
        <property type="nucleotide sequence ID" value="XM_062820773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUL4"/>
    <dbReference type="GeneID" id="87857927"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="23"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="419" mass="45065" checksum="DEDCC850EDB205DF" modified="2024-05-29" version="1">MADDIETQAEKAQPVTRSIHPVFYIASWILFSNLTILFNKWLLDPDRFSYPTILTCWHLIFATIATQVLARTTTLLDGRKNVKMTGRLYLRAIVPIGFLFSGSLVCSNMVYLYLSVAFIQMLKAAAPVAVLLTAWAWGVEQPSQSRLINVLFIVFGVGLASFGEIAFSLTGFLFQLGGIVFEAMRLIMIQVLLKGDGQKMDPLVSLYYFAPVCASMNFVVALFIEFRSFHIADLYNTGLWCLLLNAVVAFMLNISSVCLIGKTSGLVMTLTGILKNILLVGASVMIWQTSITPLQFLGYAIALAGLVYYSLGRDQIVEIATQLWTFLRNVWENSPAYSSVSSSEEGNGQQPGGGGLPSAVRRALLMGLGVIVVVILAAGYIYGGADPRGGGGGGGAVGVSRPLGGGGDASSVKPVQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVV0</accession>
    <name>A0AAE0MVV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_417509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686208.1">
        <property type="nucleotide sequence ID" value="XM_062824093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVV0"/>
    <dbReference type="GeneID" id="87861247"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000542">
        <property type="entry name" value="Putative rnp domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="296"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3354830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="451" mass="45711" checksum="2C8FB29615C06AE0" modified="2024-05-29" version="1">MSYPGPPGVSKNTTHSSLPPRPPPAKQPGGFKPAFQPAIHSARSFSAAPSPSPAPGYPATPTTAAATSSYTAAPGYSPALGAAAPGSYGAPTPYGARQPALPGVGGGRGGYGQANTTYGSYPQASGYQQQAAYGYGTPGNGSYSTPPQIRNPFPVPNAAPTAGHHGHHHDATYDPLEAAQIAAWQSAYMPKEPNDPNNANNKAAGAGNVPGARGGAGAYGAGAAQYGAAYGAAMDPAAAAAAAAAASGTAGDPYAAHNGSNSTTGADGEKKKTVVREGGGKKWTDDTLLEWDPSHLRLFVGNLAGETTDESLLKAFSRWKSVQKAKVVRDKRTTKSKGFGFVSFSDPEDFFQAAKEMNGKYIQSHPVVVHKAKTEIKPTVMKDDRKGGKWKDKKNNHNKKKSGSGMGAGAGHDGGGGGGAGGGYEPHLGPAHGSGVTKPGQKTKGGLKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW62</accession>
    <name>A0AAE0MW62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_504711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686046.1">
        <property type="nucleotide sequence ID" value="XM_062827936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW62"/>
    <dbReference type="GeneID" id="87865090"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="119" mass="12957" checksum="07B8BA0E3F9B0589" modified="2024-05-29" version="1">MALSQSAIIAPVYGQRALHPQEKHHLSRSSTTLQSPAMSSQDTRSMSQRLRPRRPSTFLTLAPIISGAEQKPKDASADEVALESPTESVKQVEADSAEALKRRTSSVSSAGGFRFLRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWH2</accession>
    <name>A0AAE0MWH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_452036</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 8"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686823.1">
        <property type="nucleotide sequence ID" value="XM_062826083.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87863237"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="136"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="379"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3355445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="530" mass="58810" checksum="1480BFCB35E5A7DD" modified="2024-05-29" version="1">MNCSRLGQPLLHQARYRSRVSSSNAAAISRCLVQGQGPKLPLSFSSPPTHPALRRRFYVQSSVAISNTTSSFHQQLLQSPQAATRTAALEPASSLWPSRSSRASLVPPANHTRHFLVRRYSQSAKMTVNNFTKKHKVTVIGSGNWGTTVAKLVAENCAEHPDTFEKDVQMWVYEENVTLPKDSKHFDASIGEQPQKLTHIINTKHENVKYLPGIPLPHNIVANPSLVDAVKDSSILIFNLPHEFIGNICRQIKDHIAPYARGISCIKGVSVTDDKIELICNYISDALNIYCGALSGANIASEIANEQWCETTIAYNTPVVDRRDENGRPVANGESNGNGGANGHSKQLTPLPLDYPPLDHDEWSLLFSRPYFTVSMVSDIVGVSLAGALKNIVAIACGYVEGHGWNMTAKTAVMRRGMQETIRFANEFFPGQIEPRTFWEESAGWGDMIVSCTSARNWRCSKLAVERNLPIEEVEKTELNGQKLQGISTTREVSSFLRAKGAEERYPVFMAVERIINQEIKVEEIPKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXN3</accession>
    <name>A0AAE0MXN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_505891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687483.1">
        <property type="nucleotide sequence ID" value="XM_062828024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXN3"/>
    <dbReference type="GeneID" id="87865178"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="283" mass="31485" checksum="4A4B6B088C3001CD" modified="2024-05-29" version="1">MPSVTHERIPSAKKRRRDDVENSYTSGNIQIPLYADYTSNYPSPLQLANPTSLYTSSHPALDTTRGILADKSSYANPTALHPYPPTLRKIIPIAINKKQRMSVSDDVHHREDSHHGMRAKSNSPTSASHPHHQKQHALLSKIKCLDRCHICFRKPSKKADLDSYADCQGCGQRTCYVCMRQCPGWTSSFHQQERHPHTGEQEAQTQDIPLASSSPENSFTMVDADAEAEADYDALAEKESQRPRSTPGWHANGHRETICGQCCEERGDNGDVVCFGCLPSFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZZ4</accession>
    <name>A0AAE0IZZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fatty acid desaturase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_83173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676598.1">
        <property type="nucleotide sequence ID" value="XM_062831466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZZ4"/>
    <dbReference type="GeneID" id="87868620"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="8">
        <location>
            <begin position="100"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3334432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="425" mass="48828" checksum="13D07CD586BF50A8" modified="2024-05-29" version="1">MTVTTRSHKAVAPEVVDATTSGADVSSSASTSQKQQASTDAIEYPDIKTIRDAIPDHCFRPRVWISMSYFFRDFAMAFGLGYLAWQYIPLIASTPLRYGAWALYGYLQGLVCTGIWILAHECGHGAFSRHTWFNNVIGWIGHSFLLVPFFSWKFSHHRHHRFTGHMEKDMAFVPATAADRNQRKLANLYMDKETAEMFEDVPIVQLVKLLAHQLAGWQMYLLFNVSAGKGSKQWETGKGGMGWLRVSHFEPSSAVFRNSEAIYIALSDLGLMIMGYVLYQAAQVVGWQMVGLLYFQQYFWVHHWLVAITYLHHTHEEVHHFEADSWTFVKGALATVDRDFGFIGKHLFHNIIDHHVVHHLFPRIPFYYAEEATNSIRPMLGPLYHRDDRSFMGQLWYNFTHCKWVVPDPKVPGALVWAHTVQTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0Z0</accession>
    <name>A0AAE0J0Z0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_553247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677082.1">
        <property type="nucleotide sequence ID" value="XM_062829947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0Z0"/>
    <dbReference type="GeneID" id="87867101"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="199" mass="23338" checksum="AA9CDA01F7A9A5A3" modified="2024-05-29" version="1">MSIPRMPDGSSFYFSSISEVYMADTRQGLKQVWKLPVHMTSPNAFQPTIPPTMGEAEDIIRRMERYDQMDGKRRVCTALELYYEQAGKKLNNEPGKNFQALWDQLVASAQEAVQDAITNSKRYERPIEWAQLRVDSKLWEARCALYAIEKWDLGLENQGIKKYEPDQCYYKLPRCRMQYPEEEDLEVYQPLILHRNGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1K7</accession>
    <name>A0AAE0J1K7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_335668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677038.1">
        <property type="nucleotide sequence ID" value="XM_062823564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1K7"/>
    <dbReference type="GeneID" id="87860718"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF5">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042154528" evidence="1">
        <location>
            <begin position="29"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="600" mass="62824" checksum="E6FC8D99C963DFCF" modified="2024-05-29" version="1">MLSSLNNPTALLGKAALLSLLSTTTTSAFNPQLPTVPGTTLNQQAPLDLNPPFDIREATVSSIHNALFTGLTTCHALISSYLARIEAFNPSLHAILSLNPHALDLASAIDLQLASGNSSANKPLLCIPVLLKDNFDTSDLPTTAGSLALANNTPSKDAPTVKALKQAGAIILGKTNLHEFALEGISVSSLGGQTINPYDSTRTPGGSSGGTGAAIAANLAVLGTGTDTVNSLRSPASANCLWSWRPTRGLVTREGVVPVGWTQDAVGGMARGVGDLGVLMTVMSMAGSDEGNGDNTTVLVPPEVKGRDYSQALYGGLGKLEGLRLGVLDGFFNHTAGEETDPVNEVMEKVLSRLEAAGVELVNITEPVYDAVTIAAKLDVQTCEFREGLDAYLEKTTYAGHGNGTTGPRSFSDIYTLGKKQFLVLPSQYDYIRNAFNRSTSSPEYFVRQHGIQQLKTTLAQTFSTNNNLDAIIYPEQKNLVVKIGSPSQSGRNGILAALTGSPVITVPVGFSEVMETTAPLGVPIGMEILGRPWTEDLLLGIAKHVGEALGPPVRRMPVGGGGLDKVVEVKGGGGGYEKEVPVVKPDGGNIPEVYPLGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J738</accession>
    <name>A0AAE0J738_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_477773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677559.1">
        <property type="nucleotide sequence ID" value="XM_062827448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J738"/>
    <dbReference type="GeneID" id="87864602"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="54" mass="6380" checksum="17C8EF0D6D9D760D" modified="2024-05-29" version="1">MSQRLHNTEGWEDDKGQEQSHPAPLQQIPTRYCSLLEHRLVIACSEFKRQDTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7H9</accession>
    <name>A0AAE0J7H9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XPG domain containing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_319879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677804.1">
        <property type="nucleotide sequence ID" value="XM_062823397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7H9"/>
    <dbReference type="GeneID" id="87860551"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="3">
        <location>
            <begin position="145"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="574" mass="63980" checksum="99761E8777487337" modified="2024-05-29" version="1">MGIPHLRKHLEPYAQRGAIQPSNLVIDGPALAYHILNLCRIKTIKNSPFEQPTYELLSRTTLEWLDRIRVCGLTISRIFFDGYLPTSKTDERTKRLMRTSKDLQGFHRKYVNGVTQGRPGWNSNRKVALFPEAQPSHSGVSPPPPAFFVPSIVDTLRQSEYYASQTKVVPGEADVFCAQYVREHGGTVLTSDSDLLVHNLGPNGSVVFFSDIESNPAGTELMGLQFKSADICERLSLQPEDGLSCLAFELVMDPHITLEQAVSKAKSKYSVAAYPGAHKEFTEQYLSPETGSQIPVEASVVLDPRISELVLRCRDKKPAMYLPFLLDSPTRTSAWESSKDIRQLAYAILQTVTGSPIPTVAEFRRLDQPSAGTPIKVPPISEVDMDAAVLEDVLSSIIKDVRNSKAVWMTLSVYQDVVMTTSQGKVQPLSLKLLQQAVDEKLDITSWECVHFLAQCQATYYSLRMLEQIMQHAASQGKGLSPALKELQDCLSKLPSLPDFPTIFNFPEMVQLIIDKKGLSCLTKICADQDDMVPQLEAIMQPKKQQKSNKRKNSQEPEARPRSNNPFALLDAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J893</accession>
    <name>A0AAE0J893_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_389618</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678174.1">
        <property type="nucleotide sequence ID" value="XM_062823736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J893"/>
    <dbReference type="GeneID" id="87860890"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="79" mass="8972" checksum="800F42339EB0796A" modified="2024-05-29" version="1" fragment="single">STSNPNLRSSLNGGNWTDSPYLKAQLLAQEQLDPMVIFGPPAPLNMEEVFSKDKSRHHRFRARTSSANWEGQDRLTEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J903</accession>
    <name>A0AAE0J903_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_474670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678176.1">
        <property type="nucleotide sequence ID" value="XM_062827258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J903"/>
    <dbReference type="GeneID" id="87864412"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="161" mass="17643" checksum="AD92A328B90CD46C" modified="2024-05-29" version="1">MSRGRLRGSTIILVASSSSRHYCAARATSNTPIMPVSFVGVHGFPCAALGTLCRPTVHRAARLVMVAVGVVGPPIRKMHSPLHLMQSLRPIILSQVNRLGLPRSGISPDFGLRVLPRVDPVTLILLVLHLLVVRLLILNMMKVLILLPKAERHILHGLDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9G5</accession>
    <name>A0AAE0J9G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_475411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678463.1">
        <property type="nucleotide sequence ID" value="XM_062827308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9G5"/>
    <dbReference type="GeneID" id="87864462"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="56"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3339103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="541" mass="59562" checksum="442736B268F11372" modified="2024-05-29" version="1">MSSTTAIRLAVRPSSWRGTGALSSGRPLSQFAPVPRRPINPSICMRQGTLRLSIRDGRLFFSTQPPKDTTENKDNKETESSNVFFMPPPPQAQAEASPSESAKEDTTADATKPETERPTAASESETSKSPESEPTTSASDSAANPSESASETTTENGNNDPTQPELPSRTEAHRARLAARFSTIMDNFQTRLLTATQTLNDLTGYSAIEQIKRQNAELEVAHGQAQSRLRDARHNYKSLTMHRASTQREVTTLLARKDTWNPLDLERFTSLYRLDHELEAQVAQAAQELTEAETEESRLSADLNAGILKRYHEEQIWSDRIRRQSTWGTWGLMGVNVLLFLVLQFVAEPWRRKRLMKGIAENEKGVIDEVRHELGQVRQALEASGLREMAHLTRLMEQEREIQALASTSSSSGSSSTSTTSSGTAAETEEGEMDLAAEFIAAAAEEAAEEAAQHQQQIPETQEEPQPAPLTWKQTAQKWQQTLSDPQQIKAAVVDLYSDRRIDVKMRDVSLLALESAATGAAVVASVAFFVLRSGVGSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAD8</accession>
    <name>A0AAE0JAD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_528889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679364.1">
        <property type="nucleotide sequence ID" value="XM_062828905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAD8"/>
    <dbReference type="GeneID" id="87866059"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37354" checksum="30C2EF6936024759" modified="2024-05-29" version="1">MSTPPPTYSATAQEVVQEERKEDGTKVTEVTDGATEAPAAAEQVLDSNETVEESNPQSVEEDRKDQEHEDDPAQKSKSESPDGQASSQGDRESSSPSPSSPDRDESAEPGEIDESAPPLPDEPLPDQTDNGESSSSAPPLPAEPAPEPEDDGWEYHWNPNDSSYWFYNRFTGVWQKENPRIPTATAAAAAVVAPVVVPSAVEPTTISNPISVAGGYNPAIHGDYDENAWYAVNARAAAEAAAAATNPLAGLDPTAAGAELASTGYFNRATGQWQAPDQNVERHSDEAKSKRQLNAYFDVDAAANMHDGRSLKAERSGKKPSRAELKAFKEKRRAKKEEKRRAWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAI2</accession>
    <name>A0AAE0JAI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_432099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679392.1">
        <property type="nucleotide sequence ID" value="XM_062824980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAI2"/>
    <dbReference type="GeneID" id="87862134"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="261" mass="28705" checksum="67A3904A1E98C8E2" modified="2024-05-29" version="1">MGKQVNLYSFPSVDTLATALRSYLISCQEAGLERHGVFKVGVSGGSLPKTLAQALLAPAKDESDKVKWESWEIFFADERAVPLDHEDSNYALLKKELLDKLPQGTPQPTVHTIDESVLDDTQELADRYEQTLVRSFASRDSVKLPIFDLLLLGCGPDGHTCSLFPGHELLRETEAWVSPIEDSPKPPPRRITLTLPVVTHAVRVAFVATGGGKKEIMKDIFEEGKGLPCALVNEATGERCSWFVDNAAVEGVSYPKRPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB07</accession>
    <name>A0AAE0JB07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_528733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679291.1">
        <property type="nucleotide sequence ID" value="XM_062828901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB07"/>
    <dbReference type="GeneID" id="87866055"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000635">
        <property type="entry name" value="Probable vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="505"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="631"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="866" mass="96266" checksum="1BD25F71483B4D5C" modified="2024-05-29" version="1">MMEVPHPTAGWEQVGEKFYRKTQLYTQVFDADLDLDNYIVAGAPYGGAVALYRDEEKLVAFAAGRPSKPSIDIYSCAGKLIRRIPWDKGSIKGLGWSEDEKLLVVTGDGTVRCYYDLQGDFTQFSLGHDADEVGVRSCKFYGHGLVALLNNNSLVSVSAYDEPRPKLLAQPPEGQVHSWSLVPPAYTLSRSVEVLLSIGQTIYVSDASECEDRFIDIGPFSHISISPNGKFVALYTTTGKAHVISSDFQTRLSEYVSKSKIPPQYFEWCGNDAVVIAWEDEVRLVGPGGSLARFYYDNGRIHILPDFDGVRVLANDTCDFLQKVPDVIEEVFHLGTDSPSSILLDAVEQLEMQSPKADDNIQLIRSNLVEAVDTCVNAAGQEFSIHWQKQLLKAASFGKSVLDIYNSDDFVDMCETLRVLNAVRFFEIGLPLSYEQYQRLSPSGLIARLLNRREYLLALKIAGYLRLPTDKIYVHWASAKVRVGAEDDDTICRKIVDKLSGKPGISFEAIARAAYDEGRGRLATELLNHEPRAGRQVPLLLSMEEDEVALDKAIESGDTDLVYFVLHQLKRKLPLATFFRVISSRPTATALVEASARLGGGVVLGNVDEDHHAHAASHNYSQSGSGSTTCEDTALLKDLYYQDDRRVDGSDVFVREALRQPEARTAADKLALAAKLLADNAKENAFELSALKEATTLLRMQEAFDRDLHPETFTGLSVNQTVFKLIRLGYHGRAKKVQSEFKVTEKIAWWIRLQALVSKRDWSEIEDLSSKNRKSPIGWEPFYTQVLQAGNQRLAATFIPKCASAGGLEPGATIGMYEKCGMRVKAAEEAVKYRDAEAWARLLEEAGRGTQEGREIERLGGSVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBH5</accession>
    <name>A0AAE0JBH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_265069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679558.1">
        <property type="nucleotide sequence ID" value="XM_062822677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBH5"/>
    <dbReference type="GeneID" id="87859831"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="919" mass="103378" checksum="5B21560B3974E4BB" modified="2024-05-29" version="1">MDEPQPPPPPPHGKNPKTSSGPNGLPAGKYDVFIIPEHSAGAGFLYLPSLQPQWNSFCAGVVSTLAALLLGKALTPAFLSWWHSGIGTVGMSILLVAVAVGSWSLGRSSSNVKLGSGSDWHKTTGEFGASGAFKTAPASEGPKPTQEAPPRPPTPPTDPETPADEWSRPLWKEKKDPEPESHVEPEPESEPKAKHRPQSPTQTRSHKRPQSPTQTRSHKRPQSPTQTRSHTKSQSKSHFKTQARSQPKPQPPPEPELRPEDDPDYEQEPVPEPPRQEPVDSQEPPHGPPTPLDPENSTKSEVSSKGAWEKAREETRRREEERKAREAELKRREDAARRLRELRERDAREREKREKEAREREERERERKEQEALEKERLEREIREKVERELRQKAEWEAKELAAIEKERLAREREGKERERQIKLEQEARQRERERLLREQLTREREAREREAKEREEKEREAKERELREAREREELRQKDEAIRLEEERKRLERDRREAKDREIREAIMRREREAREAREAQEQREREERLEQLRREDEEMEKEKERLARKETPYAMPKVGEKTSLWPNGRPPSIVTPSATASQTSHASTARTSTPRASPAPPHSPTKSPNPAAARTESPKPASPRPASSATGTADEYSYRPYDKPKNHAAARKKSVSDFSEDSFAPSATTNNTSPPPSMRAPYHTDDPGKIVIKAVYNFVNQFSKTPASQLISGVGTVTDGLILRISTAGLFVDDDVRGVAQREWDIKAWTLKQVEVWCPVLAASSSNGTGIASGAIPPSHPLFKMMPTSSAMRRAAEKAATRAFNGEEAVAYLNELGTCCSTTCRLGLNANSSGSSAIGSAASQDAEGWKFRGLHLLRTSIRDQEGKRFLFVVGEEEAWKIVKGLQSLRSGSQARAVAVSGFSGIEAKGILETLGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBI1</accession>
    <name>A0AAE0JBI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_578450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679573.1">
        <property type="nucleotide sequence ID" value="XM_062830729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBI1"/>
    <dbReference type="GeneID" id="87867883"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="483" mass="56370" checksum="D4C24FF74C5D1056" modified="2024-05-29" version="1">MASIPGGSAWSPDCRSMKKFVNNRDLLLCLGDVIGDRHLLKSLRLTSRTFAAAFERALFRVLNLWMDLFPPLLLTLAEHAHRLTVLDIHCRTNHHYKDVVPSVLCKFKGLKELSLRDIVREWDDYAKAIATVLINSPNIEALRVATWAQNRIWNVDDWNQCCNSSDPCPHALLPAICEKFVRQQRKGEGRPVNGVERTDIPRLKLREVTVDHHSMSRFILDIPDPDGNRQNPLYLEKLTDLQYLERLHIEIPPINHEEGPGIVRLPNLTPVIAPRLRSLTISPARPRESRRWHKWVLENNFLDYARQVSLGRLEHFLDNSRFENLILDWSDRVNPHESLYTLLYLLKQPATTKSLQRLELNTPGDWTELIPSLKDTVSHLGKLKYFNIHLTEYYPPLCLSWEALKRDKHFRKMVALAEDFFEVQPSLHLVEVNYFLYQVVRWGPGTRDFHLVEVLDREREWVPPEDTPWQGPEKDSVPFRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBU7</accession>
    <name>A0AAE0JBU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_279858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679988.1">
        <property type="nucleotide sequence ID" value="XM_062822862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBU7"/>
    <dbReference type="GeneID" id="87860016"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3341046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18157" checksum="96796476E5A09F17" modified="2024-05-29" version="1">MDRSGEELYQKYLEASNEMYFPPESEDLPKPVTQAYDMWSMGVLMLDVLVWGLYGGKNLGIDEVFGEMGTQRPPSPLNTDSVSPKVFKRTKVNAEPSNTKLYEPFCPSELDADANADAPSPSTPRSSGSHETAVEMRLKLTILDRNFPHPRGSRRCPACQTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC36</accession>
    <name>A0AAE0JC36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_443224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680175.1">
        <property type="nucleotide sequence ID" value="XM_062825625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC36"/>
    <dbReference type="GeneID" id="87862779"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="384" mass="45065" checksum="21B96AD6A336B8E9" modified="2024-05-29" version="1">MDRSGNGSFSHHACPTEPSSKRSEAVRNVINAIEGFAKRLLPAFHLDVSKYLPRRVSVRGPHPGRAPITWRVPLFFPEEDFAADAMHAIHTIVSRRPSTKGHNRGQLSVNNSNTMAGVTATGTTTIRNSSSMAQEAASTTSATNAPKHESEPLDTTSSQPLSDEEQEGSWKLQEEEYELTLQQLNAQRDKIKQIYDKKKAQIDKECGLMRSEVRRHWWDDRRLNELKRQLEDMTNKLQERRAIEKEWRKEEEEEEDGEESESDDEEDDEDDDEEDDEEEWDPEAAKRRIYKLETLKMRHEWEALYYRMLTEKNDHTIRLSNIEKKRTEALLKVEEEYNRDMYAWYKMRDEYHRREMGEESESRNIQHSRASYVRRLATCTSVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC84</accession>
    <name>A0AAE0JC84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_266911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679597.1">
        <property type="nucleotide sequence ID" value="XM_062822694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC84"/>
    <dbReference type="GeneID" id="87859848"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7729" evidence="2">
        <location>
            <begin position="153"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="400" mass="42417" checksum="819F3D113CCB4862" modified="2024-05-29" version="1">MMMYLFTTPFSSSKPRWARVIVSLVVVLLCLISQVTARALAIEIKDDLSTFIDFNAPLDIDTSEPPTISEGEWILLSPEQAELKHGAGGLRKREEKETTSSHTGTGTAGAVASGSVTTTFQIAVSTITEKPTTTTSTTTASPATETAAVSSSLPKFFDGSLSANFVPNSNCPAFLNSFLNNQTFNQCYPVSLLMQGSQSFFQAQRSLVSLTRVLDVSCSPNVTFCATYLSSLASDLLSDSNCGPDYRNGHTVVRNAYVAMIAYAPVYSATCLKDTTTQGSEEGYCYANAVMNFTNPSSVYVYHLALNVSLPGSTVPTCGGCLRETMQVYHEAAADRRQPVAGVYVKAAKMVNVVCGVGFVNETLPEAEIVVSSSSAVVGIKGLGAVVPFLTTAVAAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCS8</accession>
    <name>A0AAE0JCS8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_230928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680605.1">
        <property type="nucleotide sequence ID" value="XM_062822178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCS8"/>
    <dbReference type="GeneID" id="87859332"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041900716" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19364" checksum="31C36524F97B6BE5" modified="2024-05-29" version="1">MLCPLQLLLLPCFTRCICQKFPIFNLFDSEPLSPFQSSISRAATSSIYSQPQHTSSGLRETHNKERTMICHTLPHLSSPRRPNIGHHSEQTRRASRGSSEPPTWHLARFSVWLFLMEGGGKGSHAAWRVGSIPKMIHAYNAHRRYTNQVGGNSAAYRLNAPRLQAAPTRHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCV8</accession>
    <name>A0AAE0JCV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_469552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680650.1">
        <property type="nucleotide sequence ID" value="XM_062827016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCV8"/>
    <dbReference type="GeneID" id="87864170"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="146" mass="16946" checksum="58FD5878697F9AEE" modified="2024-05-29" version="1">MPVLPRQYPSTPPTEAPTALDDGWSWFGWSTLGWALIGLYIVLGITWYTTYEAERIWTWVADGLNPDRSGDKFGPRQRGFLLALFVVLSNVFVFCWPVWYILYGVGNWAASLRWYCLRCDKFCCDENGYKMHCQSPEHTTAKEFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCX2</accession>
    <name>A0AAE0JCX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_232111</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680652.1">
        <property type="nucleotide sequence ID" value="XM_062822199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCX2"/>
    <dbReference type="GeneID" id="87859353"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000432">
        <property type="entry name" value="SWR1-complex protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="13">
        <location>
            <begin position="129"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="566"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="604"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3342859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="738" mass="80587" checksum="54FAB96909DFB8A0" modified="2024-05-29" version="1">MTSHDVRDVLNLPSDHAGPRPSKKARTAAPRPNLKGLAREVQNLGGDNPIAIVPEVSIFKKRRTVSRKPAAKWELKAFTNSARGDDGALVLRHWKRKPDGTEGGQDGSAEGQDSAATAENSADKPEDSSFAKFNVRVSVPQYSEDQYNTNLKHPDWTKEETDYLLELAKDFDLRWPIIWDRYEYAPQQPEGETPDGMAVVPASKPRTMEDLKARYYEVAAKMMAVQKPAQYMTRPEFELYEMMLHFDPKQEQNRKRFAENTLKRSNDEAREEEALLLEIKRIMARTERFNEERRELYNRLDYPASESDINSFKTSAGLQSLLQTLLNVDKSKKRKSIMGPENGVPPAAAAAAVAPPAAAAAAAAVAAAPEVPPAASRRESLAASSTAGANDHHEPPAREPPVRHERQDSRSHHRNESRSERADRHGHGHHHRDSVSQTPATPAEPPTPAPAPAPAANKKKGPQQPERRKLSENEEQVYGVSHHDRLGSGPTFRYEKINKLYSHKSGQQQMRITNLLLELDIPARLIMPTAAVTAQFEVLWGAVTTLVDLRKMSDKVDAEIKLEEAKKAEREKTAREEAEARGETVEKKDGEEEGGGGGEAGGAGDKEKDVGGGGDDAKDKSAESAQADEQKKDQKAEDAKAQKEQQGEGQQQQKKDGEDPAATTKEGGGEKGQGDAAAATAGEKGAESSSSNQPKIKEEADENGSSSGAGAGAGAQQHKRSASVLSNASDRSTKKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD13</accession>
    <name>A0AAE0JD13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_576523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680685.1">
        <property type="nucleotide sequence ID" value="XM_062830663.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87867817"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1409"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="540"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="835"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1429"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1472"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1519"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1570"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1626" mass="180322" checksum="16174C883079DFB8" modified="2024-05-29" version="1" fragment="single">MDHPPRTRPFNFENSEDNAPVGPTSYQHAQPSSGDQVPYSGIASPNSEHNDAYQNKSQTSQDVIQETPRSLPLAPEEMGLIERPRMKKTFELDQEFEFGPALQINPGQFTKQLKNPGPLYQSTQSPVLTSQPASKDKKTRQFPFPLQEPLPGQQIEERISNDVVSAHNRPPPGATDQPSSVIFHEHEAQDTEQPPERTVDTRPPPKGRPFADVSPPSAQRALKVAVPLPRPPISIPRVKTSRHFTPGQEPDESRSQTDHRASAADASRLLQQHGNPAATVNGVHISGNGDQFLVSHEKGIALDGKYLSEGRDGQSKDRSSPTSTTMSHKGRQPHPDRPHYQDIHMGDYTLPGNPEAEDVVNMGSRGPHIRSFDRPDTQQPKSTSPYFESLRQGEPSHTSRQKPHKSHDVSDTNTAGSGKPPNRGAEKGHSSLRTQHVSPIRRIAAASAARLHKHHASRDPKSAYKQSPRPPLEGSNVSRRRAAVSTTARSEIIDITSTPGSEIIRSSPATNNKSVKISQEFTKDLAGVLNRFTTQHNSTRQELRERYHKYIKQLKKKIKDREHEAEEYLARVEEQAIDIRELEHSNGKMTKKIEELEHSKGKMAKKIAEMEAVLEATTERGSKAEDKYRKVKDHLNAAIEEQQKLYLMSKSQWEKAIKEVRETERSHGAALGEMLQKTEVIRQQMLEKVRQTVGQLYGQIDTLTRQIEQKDAELSHEKEAVKMLSQQLGTLKITNEGLDALGSQQKDILGKMDEQNAQAIQRQAKTEDAFGTRLDAIAEQVGTVSKAVSEQPQALSILQSQQQEILELITSKLEAVMESSGTTEKTTTQISTDIKAHMEKILRQLGHEKDRLSQQLNENLTENGRLAGCIAEKEKALKTCQKELKDLQKRFENQQIQFSQLQAHAVELEVAHEDNQPLNQQLQLAQAEIERLEAEVSSRTAAISQLEKTIRSKEETYVSEVKQFGSQVQQLNQLIMDKEAIIETASAKSVDLVRRELLAEKEKETAELNKKISQLRSDRNALDEVVAQLRQERTSKEEAERQQARTIESLKASLAIAENKCSSLAEELKTRSDDLAESRHQRSTRISALEADLAVWQKKAVELEASYTGLQETERQHTGAIDSLKVTLAATESKCSSLSEELKAKSLELEKSHQRSSSRITDLEKELASWQKKVAELQATYSEVQQIEKTRQGKLQECLTTIEQLAVKEGLVASDAGSSKLFDIGITLDEAWPKISKAVEQLMKMTSTKHQANLDEVRQRLEALKERVSHTGSSTNEDSQASLVNACNNLEIRPLQESQGGNPDGVSEMITTPPNTEETSPPFLQHRVVVGLQDQERRVAVRRPTSTEGIRKVPLPPPPSVAQEKSRRREAVPPKSIMKRVTRSASREQLIENSSGSGAFGRIGPLETFTATPPESTGAFLEPNPVSHEVTSSHFSDVSASGRPNKRKRSDDIVDSPVVVRRGRYSRGAGGKSTTKAVASTPASASVPNGSDERGPRGIVQPQRIYRSRHAMDKLSEGSKPSGNGSTSINFKPSSSLPPEVLNGANRFLPPRSAPTRTYGSRKFVGPAEDTSSASQTNGESQARSQSQPLSRYWGANDETQDSMTLSQNASKEDGNDLLLPPPGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD40</accession>
    <name>A0AAE0JD40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_443738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3342964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062825643.1"/>
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        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3342964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062829693.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062824592.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87861746"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680497.1">
        <property type="nucleotide sequence ID" value="XM_062824695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDX2"/>
    <dbReference type="GeneID" id="87861849"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="762" mass="84377" checksum="0F2D672D2DCABE4B" modified="2024-05-29" version="1">MSRRLSAGSGEIEPDTPLRYASPFLVSPSKANTLLEESDGEKSDGTELALLGDNTCSCSPAKGGVKFKIPKAKADTYFVWSSNNPPPDFETIANARGKAYCASIKLKEPPSSTTPPPIHRGSVVAKAEDCLAQLEDDKPAEKDHPRSSDEETVRHSEDSQPSIPKSQGDNIHVNSIHNDDDHCNETSIVEIIRVLLLTFSTVVRGTSRLALFSILVPLSFVKRTGLLVLCALFEVAKLWLLFASQCHNTLLLITKKLTLIAKIQCIKGLTWALQLLIWSKTSKAALRRDEGPAATEDKGKAMDHDVDPSTEAPEPTPTREEAPTPLPNNPRFVSTAMSSAYWAGRFSSLHDRFHSELLTPRNLNLIIEAHTFCSTISSDLNNSTSTPVPPTASAFNNPSTSVYASSRIVPTRDLNSYTPAKRHSNADQLGLKTTDHRHIPHYIRCIPHSATTDAILQTSRKSSTYVSERNPAVYKTVQHEEISHPKASSPSMIPTRVIPRSESSRILPRRPLPEPPVSESSRVLPRRPLPELPVSESSGIIYIRPPTSHNNNNYPSTNFRMKNTDRPNRIMSESQAKAQKEREAMLRRVTVADATALTDDDNRCRRVFLHLEACCLTDEARNSLYAWQQDYARKTQREVLLPKGGTMHDPRSFRNSVFGRSLFGSRRSMGSLPSGSSGGIITTGLNVDLGQPQSEVRPSKTERSLLQVPRRVFTHGRSASMKVDSLEPSSYGHRLERHGTVRGVNADHEVRKGRYQHRMSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEC2</accession>
    <name>A0AAE0JEC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_429446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681011.1">
        <property type="nucleotide sequence ID" value="XM_062824825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEC2"/>
    <dbReference type="GeneID" id="87861979"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="81" mass="9482" checksum="65BE8122CFEDCD5A" modified="2024-05-29" version="1">MTLAVRAIVELFRIVKREDEVHRQILTFSVSHDHHVATSKNTPEPAKGFYQDCLIFYADDEETIMMPQDEEIFRSSRILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEI9</accession>
    <name>A0AAE0JEI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhoD-like phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_548349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681166.1">
        <property type="nucleotide sequence ID" value="XM_062829571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEI9"/>
    <dbReference type="GeneID" id="87866725"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF8">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="182" mass="19650" checksum="9D1AB9352192E87D" modified="2024-05-29" version="1">MGFQGYVASRNRTLQYLYDNNISDNVFLSGDSHQNWVSDLAWLGTKPYDAATGLGAIGVEFAGTAVTSSGHSGIIATVQKATKTKVDSNPELQWQEGYYRGYFHLSIKKSKIDAQFFGSPSVATRNGWDLSLANFTVLAGDNHLQRPVGGGRVEAGSLKGGKTVGTNVTLDTNGWKWEKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEP2</accession>
    <name>A0AAE0JEP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Telomere repeat binding factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_185548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681398.1">
        <property type="nucleotide sequence ID" value="XM_062821567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEP2"/>
    <dbReference type="GeneID" id="87858721"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="711"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="826"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="923"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3344785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1145" mass="124345" checksum="69648098DCE695CE" modified="2024-05-29" version="1">MADLNLTAAIEANLLAALSKHTEEAKSPAPAPTPAPGPAPVPTPTPASIPTQDVAPPPQPVQQQPQSQQPPLNHSVQASQGPPSQTIQPPQQHLSQASSLSHALQQALQSSNPPSYQTPSTHQPQPPSTTAAPISQPLVQAPPPQPNPHAASNVPPQASPVLAEPSKKRSRSPDPEQDSNGKRPKLEHVGEMDQDIPYDIKVALATALGDFEKQHGQVGNDSSLENPSGSSSAPPPAPAISLSATATPMPEKGGDKLMKASSNSTYMIRSMSLPVLGNLAVQILLRLSQQPRNETLSLLSETDAEFRKHYDLLTESFKLARRGFSDSPVLLPDELEINDSEDRETIRVANLATTAISVFGANDVACKDLDDSFFSIFVPEDGEFKDTLTDLLLSLKTQALLDSLDEHATPQQVTEQLEKFFPDNFEDWLKQRNLEVVTDTDADQLAVKVKERRELLSTVANNEQPKKSLESKYPSDTFPETLCAFLQSHIGVVVEYAEEYGVKIPISEEPIVSDPVQNGNNVQDEHADLAALLQSKIVENGELKDFHTGNLNNEASVSADDNFDLSKLIEQSLPDHINGMKDGLLEQNGQGESSGLFDTKDLASLIAEKLNDNLETPVHGIPNVPQNSYEDTMRENQGQVHPQYHNLNQLQTPTYHQYPQTSSSNIGMGTTGETLPPNQSCPTSVLYEKARQAAVAKSSSTTRREGLHSTRRPWTPDEEKALMMGLDMVKGPHWSQILSLFGAHGSVSDILKDRTQVQLKDKARNLKLFFLKTNSEMPYYLQSVTGELKTRAPGQAARKEAEEKARLNAEDEQARLAGIMTLGGLHNNHHQVAGSPIAPSPARPHTATPGPGTGHLNGTPTPTPTQVPTNQPAALAPVPISPMVKSEPVDHSTHQVSNLPQIQPAPAPQSLQPALKPQPQPQPLHQQQSQQYLQQHPQTNAQQHPQQHSQQHPQPLQPLRPQQQPQQLPQSQMRSQTPQTLAPAPAQQYQKQQQQHHHHQPQGQQQHQQLHQQQQSQQHLQQHQQPQAQPQPQVQAQPQQQQQQQQHHVATTPVSTPTTTTATPATAAAQPHVSVAATESAPASSTLSNQATPSFGLPPIPPNHHSTPDQAQDVKLFETLQAAIGATSPAHESHPAATVSETSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JES6</accession>
    <name>A0AAE0JES6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_470548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680947.1">
        <property type="nucleotide sequence ID" value="XM_062827047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JES6"/>
    <dbReference type="GeneID" id="87864201"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000012">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF11">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="221"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3343154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="506" mass="56551" checksum="A4382D79B2AAEE1C" modified="2024-05-29" version="1">MVGRRPRIVNSATDWHGTTPSRRPSSIRQRYRDDDQESGLLSRVSPGDHRDPRSTEPTSTPAAPTRIPSPHEHEVQIHDDRAKVTSLSGFKDARHLAIAEQRRNDLKQRVFDGMKGFSSWEEQHRKSYAELKAIKNKKIRRYYESQNETLDSWVEVDALVMAVADDVIDSMNPDADRDGIAERRVPLADSKGAVEAFLPPEHIEKRRRNDRNARWAINTNVIANVFMLVGKLVSLRFSPSLSLAASTADSALDLFCTLIIYGTNRIVSWRLRALQLKYPVGRRRLEPIGILVFSVIMVVSFIQILQESVTKLLPGGDRDAAPLPPIAIGAMAANAVIKGIIGLICRPIKTTQVQALVQDCKTDVYFNTASLLFPLVGVTAQIWWLDPLGATFLAIYVICDWAETCIENISRLTGSSVDDALQKKLMYLAFRFSPVVEGFKSLTAYHAGDGVWVELDVLLDESTSLPLAHDIAETLQYCYESLQEVDRAFVTVDYSSLGPTGHNQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG26</accession>
    <name>A0AAE0JG26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_427074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682254.1">
        <property type="nucleotide sequence ID" value="XM_062824663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG26"/>
    <dbReference type="GeneID" id="87861817"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042768">
        <property type="entry name" value="MNX1/Ceh-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335:SF4">
        <property type="entry name" value="EXTRA-EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335">
        <property type="entry name" value="MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="143"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
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        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3345641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="949" mass="100188" checksum="545ACADCEA602CA0" modified="2024-05-29" version="1">MSRHHTGPLSAATPGDGVSYGRQQQQQQQQQTQQQQQVTTPQTKWHSPHPTYQHQHQHQHQHQHQHPQPHHHPNLASFVKPEHTPMNSHSHSHSETAWSARKSSGSTVSAATSASSRSPSPGTHSDLGSNCYAASISSWVTSNPPSTATECNFPEGDLEPSESVGMGMGKKWNDESLSSSSSSSRSPITPVSRFTIGGRPAKKGRYNAPNGNGGGGGPGSGGSSSSSNSTSGTRSPSRPSSLRNAMFAVDSSAPHPHPRSAEAEDMMSCESDAESGESEDDDMDIMGDYLDDNSSEEEEEEEEDDNDWSGQNGNLESAVIEAVNGDLPLAAYLIPILHRDYNLAVKNKVESWQFGNTSGSGSGGNGGGGAHGGNNLRERGNSDASRGEKSSYTNSPPGGSGGNGNGNSRKRRRRSNSDGGGREGRGFGNGAGGGRGSGDWGGGGGGRGGGGDGGGGDDGDEDEDKNIDTGSGPGVAGNEESQPMLACPFHKRDPEKYGIQQTNSANGKKHKYRACTGPGFKSIQRLKEHLKRVHSPVQCNRCYKIFPGTDRATCLANLSEHQKESDACDLGDPSQKEGIDAVQWAALERQNRKKNQEAHKLEKWFEIWDVLFPGANRPETPWHDIKPRITPFSPSKDGDAFSKLFLDILDHKIQHQDIDFSSMGTDIVRERLKSVVQQTFKAYVSLHGHLSTETSSSELSNGPGGRNRLSIVGGSSTHLSAPATAASHQMSNTTTGTAPTSLGMGTRNNNPQAQQMNPYAQHGIPTSPFHSHSHSHSHSHYGHHSPATQHQPQFMAHSPHNGPMAGVSPHAVNAVNAAAMSAAGYTMTGAEDPTSVASAVGVNGGGPAANYFYTSYAMFPPPPHPATGTHAHAAWGAPGQFVAAHHPAAVQAQFGMPHPAQQQIGSVGPHGSVGQVGNVGQVGQVTPDHMDVGVGGYQFEVEAGVSAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGA7</accession>
    <name>A0AAE0JGA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prion-inhibition and propagation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_509273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682223.1">
        <property type="nucleotide sequence ID" value="XM_062828298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGA7"/>
    <dbReference type="GeneID" id="87865452"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0034">Amyloid</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0640">Prion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="4">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="268"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="6">
        <location>
            <begin position="529"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="968"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118400" checksum="143414B2F58A7C85" modified="2024-05-29" version="1">MEPAGLALGVIGLAGIFKSCVELFGYFSTYRSYGHDYILLDAKLHVEKAVLLQWADRVRLLHDDYDRRLDNPTIREAVSEILSYIIHLLSESSSLQQRYGMKEAEASPPHPPKPQNQTIGGSLMEKFMDDYNAMQVRMHQRKATTSTSSKLKWMIVDKDRFNALIEDLSHFTSRLDRAVSLLASLLRHEMASIYKESSKTVLQQATDDRLGKNAILQEAQDQDKALKSLWFRCMGDRKDSVSPAHVKTLQWALKPACEREGREAEWDDLSEWLRSGTGLYWICGKAGSGKSTLMKHLHDNPDTRAPLKAWAGDLPLSTGSFFFWGLGRQEQKSLEGLSRALLYQLLEAESSYIPSALPRLWQEIRTDVEKVPAPPSSGELRAASEFMVKNFQPKRRFCLFIDGLDEFEGNFHDAIKGLCSNSEIKIIVSSRPIAICYDAFSRLHMEHLTSNDIKEYIQDTVGSHAYMEVLTASGEQSPNMITNKLIEKASGVFLWVILAYGFAAHDTLCRRVDDLPPELEDLFVHMLNSVDRRYHEQMAKTLKILYSEYRARDSSDAGLKTIKLACFNRNDMDCTSNLPLESFPVHEARKICLAMVARLRSRCGGLLQTVPRWGWGHGVIDSNDRLPYSLKDKVCWCPLREKCPQVGEGSHPLSPKYKVGDFAEHSQIEFIHRAVFEFLDNPNVWNLPPLRISDPTFSAACAIVGMDLQLYYLYCKNGAETDATLDWLLMIDNKPLECVVPVLAKLADCVSLRIAQKDYTTEETIQPSFSSFLKPAYDRSSLQLSLLMAVELGLVNTVGSLLPTVGPRPLGPRYFPFPILYHSVRSPLLYSMIGYLLSQGFPPNELFADERGLPTTPWRSLIVLEQKFWQTRDKDPPYKSFLTRKSTHDMMRSFIEHGAELDYVVPGISTVEEFFNSKFVAFLPEDPSPNAIAERRRYDNPNGQLPLQNHLTLRSLRLARIMAAETLASSAGSEQDKGPDTQLDGSLDTQADKKVDGNGKADTGSNPKPDIGRKVNLKAVQEPLWWLLVVVILALSIYMKSGFLSQVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGF1</accession>
    <name>A0AAE0JGF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_466931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682141.1">
        <property type="nucleotide sequence ID" value="XM_062826882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGF1"/>
    <dbReference type="GeneID" id="87864036"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3345528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="522" mass="60170" checksum="9FDDE516D274E0F5" modified="2024-05-29" version="1">MAVLNWASSRAATLSPGTAALLVITTWLLYITSLAIYRLYFHPLAKFPGRKMAVVTTWYEFYYELRYGGQYIFEIEKMHKEFGPIVRINPHELSIHDPEYYNELYVGSSKRRTNFWPLFQGCTDDTDVNHFMTIDHDLHRQRRKPFDPFFSRMAINTRYWPMLTDKALFLESRIRGYRGQGKAVRLDRAFSAFSADCIERICTDDLEPGDGFLDQPDFGPEWYDGMLGLIRNAPILTKFPKALSALGYMPQRLLLWLFPQGHIANKYDERTRTQIHKAVTKQHLSKDASSEHITLFRALAQSNLSPADKTEERLVREAKLIFLGGTISTGRTLSFVSYYILSRPDIKARLADELRHVMAAWPEVVPTWTELERLPYLQAVIKEALRLSYGFMRRLPRVSPDVAIQYKDYTIPPGTPVGMSAYLMHSNPEVYRDPDQFVPERWLAEDTKAMQRSYVPFTKGSRSCLGQNLSMAEISLVLAVLFRPNGLGMELFETDESDVKHVHDFVVPLPKLDSLGVRVMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHG5</accession>
    <name>A0AAE0JHG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_154416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682823.1">
        <property type="nucleotide sequence ID" value="XM_062821130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHG5"/>
    <dbReference type="GeneID" id="87858284"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="202" mass="22527" checksum="D216E3587D443D66" modified="2024-05-29" version="1">MSAGHERISTWLQLRPICSRRQVLPTRQTAAVTDVVRARIRGSFHLHICTYIGTYIGRVPPRFVPFRLILPFCPCRSYQHTPNIDFSSSGQHPWNSNSPSFTRPQASDECRRRTRDTIEASSMAQTSMIATTSKVGTLRALQGKKHRQSPMVASTEPPFSSRLGGGPTGAHRPTLWPKTSQPHARYAPEAFAVVRPSSPLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHK5</accession>
    <name>A0AAE0JHK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_152161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682721.1">
        <property type="nucleotide sequence ID" value="XM_062821089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHK5"/>
    <dbReference type="GeneID" id="87858243"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="101" mass="11651" checksum="BF2FBB3556D99F56" modified="2024-05-29" version="1">MGITTKKQAIKMVNDFANSPAPIINNNRRVTMARAIVELAIDSLRERPNLDWLRDLAIQEVERSLKVHVIAGMRGKHNQKVLLWHTIVEVMDHKKHQIPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHU8</accession>
    <name>A0AAE0JHU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_424711</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683174.1">
        <property type="nucleotide sequence ID" value="XM_062824524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHU8"/>
    <dbReference type="GeneID" id="87861678"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3348092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="249" mass="27241" checksum="3ED680445BB4560F" modified="2024-05-29" version="1">MSKRPSHASVANGAATQDDSTSAAVTEFDRSHDKQKILFSTDAGHFSLIRAMHLADLITELNGLCGILSLFSSLRYCLGDPADKTNLYYALAFLPFGLFFDFMDGKVARWRKKSSMMGQELDSLADLISFGVSPAVVAFAIGIRTPLDHLCLGFFILCGLTRLARFNVTATAIPKDANGKAAYFEGTPIPTTLGLDAIMAYWVSKGWIHDSLPWGTMFQGTALEFHPIVLIFMIHGCLMTSKTIHIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHZ3</accession>
    <name>A0AAE0JHZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_422814</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683310.1">
        <property type="nucleotide sequence ID" value="XM_062824420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHZ3"/>
    <dbReference type="GeneID" id="87861574"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000039">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042276193" description="N-acetylgalactosaminide beta-1,3-galactosyltransferase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="14">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3348228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="482" mass="54835" checksum="8AE5F8D4DEB37D03" modified="2024-05-29" version="1">MFTRKSITVALCATISLLLLLATSRRLGGWAAIDDPLYQSDGRGHHHPPPPGHTGPGPRPHPSEIPDCAGYPIPDNILVIMKTGASESFNRVPTQLLTVLKCVPDFLIFSDMEQKIGGYQVYDSLSNVSAEAMEGNSDFDLYRRQKACPVDVEGCNKQGNPATEGWNLDKYKNVHMAEQTYKMRPGYDWYVFVDADTYVLWPNLVQWLGKLNPNKKHYLGSVTLIQGFRFGHGGSGYIVSKASMKALVDENPGVGQRYDLRAKRECCGDYVFALALKDNADVSVEQMWPTINGEKPATLPFGPWHWCHPIVTMHHMNSEEIDTFWEFERRFRKEQLASGNPRPLLIKDIYHEYLEPKLKREQLDWDNKSDDRFYVDLAAKEWDEGTLHRMKKASDYNELEKVAHRSASDCEAACKSLPPDDCVQYKYEDGKCAMHKSFILGKPVPKKEGAQQSISGWDVEKIKEWTEREKVCDKIQWPNLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI54</accession>
    <name>A0AAE0JI54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_165880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683183.1">
        <property type="nucleotide sequence ID" value="XM_062821298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI54"/>
    <dbReference type="GeneID" id="87858452"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="70"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3348101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="276" mass="30334" checksum="DD94187793266B43" modified="2024-05-29" version="1">MAAQTLPASGAAVTFNTQRTRAYLLKLPLFTRATVLIIVLTWVLTLVGKSWNWDVKTWGALIPDEIGIATLYRINTFPFIHLNIFHTILNIVAFTPLLERFEHEYGTLTSVALFFGPFATIPGLIYVFIERFILHANTPVMGASMWVFLLLGMEAIRTYKTNPSFTISTYNIPTWITPLLLVVVTAALLPSSSFLGHLAGLLVGYGFGLGYLKFLAPPEWALRFIEGKLNLLGRLPHYVSVDQKTFGRFGVLPSSASSAEAGIPFAGVSGGQRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI55</accession>
    <name>A0AAE0JI55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_158577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682981.1">
        <property type="nucleotide sequence ID" value="XM_062821199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI55"/>
    <dbReference type="GeneID" id="87858353"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="175" mass="19656" checksum="73BE61DE8608D555" modified="2024-05-29" version="1">MRTDSMNEKLIDARSPLPTNESTGIKYSIRPIFRDSTCPLFFEPFLSFPFLSFPIFLFPNTSSFFYISNSTTTRSTTQPKKTAFSCSLGQPSTTTGQPANRPTRHPTQCALRCGPAELIRTTLFGKVRQPILFTSSRSSPTLLPSFLNFSQTCLLCPLLNAFSRQLCPSYTRSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI61</accession>
    <name>A0AAE0JI61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_169706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683309.1">
        <property type="nucleotide sequence ID" value="XM_062821349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI61"/>
    <dbReference type="GeneID" id="87858503"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042192456" evidence="1">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="78" mass="8691" checksum="98B074063FDC1FB4" modified="2024-05-29" version="1">MVKRFLLSFIIVIIIQMCPTMCHLLSHGSSIPKATITPSILSIISQVQLLHIRKILCPDHSNPMIFQADFFPTLAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI62</accession>
    <name>A0AAE0JI62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Quinic acid activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_162037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683081.1">
        <property type="nucleotide sequence ID" value="XM_062821255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI62"/>
    <dbReference type="GeneID" id="87858409"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000005">
        <property type="entry name" value="Quinic acid utilization activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3347999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="822" mass="89632" checksum="BC7B0087148ED1E9" modified="2024-05-29" version="1">MPPKRKTLDAAAEANAHVDAHTDAHAVGNTSANSNARFASAPNLNNNDIPDLGPTTTSLVEPARSKRQRVSRACDQCRAAREKCDGIQPACFPCVSQGRSCTYQASPKKRGVQTGYIRTLELALAWMFENVAHSEDALHNLLVHESGQGSALLVGKDSPAAERLHARWARSRVNKSITRLLSGQAAQSPSDDDQSPSEGMNVEDAGAKTTELPHAPHLSLSAQSTVQARTLPGAVLPHNSANALENNIQPDERAHLASTGIGKLPPNHWRLLDIYFSYTHSWFPILEKKDMYQALYQYSEQGSLLPSANVESGVHAELWSALALASFQAAAAAAASNSPDPTSTAHGGDNAINPSPADIFDTARKLIPSESGPFQVQHCRALLLLCLVSLGRDDWESAWLLVGFAVRVLLVVRTQSPPDDERLRPRMRALLVACFIVDTIVSMRHNVPAHLKPDDIADLPLPEDGQDQWEPWTPCEGLGGEHAMLQTLRNPAYPLSTFNHLYGVTKLVALELLPRIRISSQNASLEFRSRLQQVIGHNSPFSVFILSQDAASAFVPTAYLTRTVYLWAAAFSEPLNEHYSHLLIETLDQYQKRFGTYAIPPLIPSLLASLFALKEQSHCSERHRRQLEEVLPAFSSIWSRVGRHNNTDLQPIRLLEPPPAATATPNAMPHVMEQPPSTSINPANDRFIGLPNPTPYNSNAILDAVAQPDGPRHYGSLHAHGILSTYPPPATHLGEASVALAHGGAPPRPPLPYVDSTTNGPHHHTNLVPMANFGYSTVDYDAMVDDLASIEYTDAVDVDPQFMTNLGFVPGCNFSDISTYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JID4</accession>
    <name>A0AAE0JID4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_508158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683303.1">
        <property type="nucleotide sequence ID" value="XM_062828204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JID4"/>
    <dbReference type="GeneID" id="87865358"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="KsdD_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009472">
        <property type="entry name" value="PRK12834.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="3-KETOSTEROID-DELTA-1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260:SF1">
        <property type="entry name" value="KSDD-LIKE STEROID DEHYDROGENASE RV0785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="4">
        <location>
            <begin position="25"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3348221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="592" mass="64454" checksum="272E97130AB25681" modified="2024-05-29" version="1">MSSRTPSSPGPSPTPLPTPTKQHPIIIIGTGLSGLVAAFELSRANIPCLLLDQEPRSSLGGQAFWSLGGLFMVDSSFQRRMGIRDSRALALRDWLSSAQFDKLEKEDYWPRRWAEAFVDFATDEMEDYVKARGLGFLVNVGWAERGDGRGAGGHGNSVPRWGTGPEVVRVFREPVEKKEREGVVEMRFRHCVDEIVVDEGTGRAVGVRGRVLEDQEGDGAVPRGVSSSRVATGEFEIRGAAVIIASGGIGGNLEKVKKNWPIDRLGPKVPATMVMGVPAHVDGRMIDIAEGVGASVINKDRMWHYTEGLKNWDPIWPGHGIRVLPAPSSLWLDATGKRLPPFLFPGCDTLATLKHICSTGYDYSWFICNRTIAAREFALSGSEQNPDITNKSIVQTLRQRVFSSNGTVPVQNFVKHGEDFVVKDNLEDLVAGMNELMEKTGGGVRLDYAAIKEEVEARDSQFDNPYSKDAQAMLINSTRNYWPDRRSRVAPPHKLLDKKHGPLIAVRMNLLTRKTLGGIETNLSSNVMRTDGTPFPGLYAVGEAAGFGGGGVHGYNSLEGTFLGGCIFSGRAAGRAIVEEVLGTTTGLQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJC5</accession>
    <name>A0AAE0JJC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_588130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683392.1">
        <property type="nucleotide sequence ID" value="XM_062830998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJC5"/>
    <dbReference type="GeneID" id="87868152"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="223"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3348310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="312" mass="33517" checksum="EDB12B6FA7AC2533" modified="2024-05-29" version="1">MAASAADIESHDGQNAGLQTAKDLFSGAVGGIAQVLIGQPFDIVKVRLQTSTQYSSALTAAASIYKNEGALAFYKGTLTPLLGIGACVSIQFGAFHSARRFLEQRRSEGDKSFIPGVSNLSYGEYYAAGAFAGVANSVISGPIEHVRIRLQAQPHGAGALYSGPWDCVRKLSAQAGGVLPGLYRGEVVTVLREAQAYGLWFLAFEWLMNADAARNKIDRKEIPSYKIALYGGLAGEALWLGSYPLDVVKSKMQTDGFGSTQKYKSMRDCFGQTFRQEGMRGFWKGIGPTLLRAMPVSAGTFAVVEMTMRAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLR8</accession>
    <name>A0AAE0JLR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial protein Pet127-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_457587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684637.1">
        <property type="nucleotide sequence ID" value="XM_062826362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLR8"/>
    <dbReference type="GeneID" id="87863516"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127462" checksum="C057EF1E1ED7B73D" modified="2024-05-29" version="1">MLQLTSKTRRTIKPHILRTSCLTLISNAHPRPAPLYNPARLYSTEQPDKPSSDANTPELKDNDFKPAPGKQRLHPRALRSKNTKKRGGAPNTQPLTNFLKDLETGSLNAGQQKQATTKTPETPEPTTTDGAQDGTPAAAEGGSKKKGKQAKKSKPSSSPAAVANDPKLMQRATAVLRKVLEKELRAEQDSMGSEAGKDKSKYGKKKKQKSTETKPTEPKSLIRRHPTDGKLKHPGVLAKVTAAAAAATSTPDTSAATTKQQTKGASAEPKARSPEDLQWPPPGRKLHVRRVDPDLIRMVPVHKEQPPVPGLSYGLDRALFNPGVYHMQDPRSRVWNFDPYLARIMPIQEFDFNALKQYITSSKDTTLIDIAREANKKYTGSTSSMTSTLAHFHYLLSSWRPITTGMMSQSFRADSTNFTRIMRAPSAAFLHWKDGVYAIDADKEFDTANILSMLGKSMEKLLTLPKEDFEKYRKTKSHQLTEEERDSPESYHYTKLGDFMMRSQLDAYDPRIPGTGMFDLKTRAVISIRMDAKGFQKGLGYEIRHRNGNWESFEREYFDMIRSAFLKYSLQVRMGRMDGIFVAFHNTQRIFGFQYIPLTDMDYSLHGTRDTNLGNKEFKLSLHLLNKILNRATAKWPEQSLRLHIETRPTDPPLMYIFAKPVTPDEIEKIQGANKKIIEKFERDMMGLEPKGEKEEGVADEKTTEEAVEEATEESVGEPEAREEVTTADVWEDMVVKVEEALENEEHGVTSVREAIEQALRSSGLLEASAPEEARRYLDELLEALTSAESGKADESAADSLAEESESVTAAEETTDTKTEAGQAAETEEEPTLKDLVLRLASQVKADRSEVAKGEAEDDVSAAAADDSKLRKFETILSELISKSRDTTEAGEITEGEQPTTATDASASATTKSQNPEDELASLDETVHTKTNDNSILPETKPELLGMILTIRNKVNGEYVERPEHLRRTDKWEVEYSLEDMPTLRAETIYKMVIQRRSKTLNDQEDRDKAWYEMFQGALDKYTRKGRLHRQKEIELGKTRPVHVYGMDKPLDWESVFGEGKEEGMSYRWYGQEAENVESGTIELSPEEVEEDDGSLPVEEVEGAEEGEVEVDVAAFSEDNKPEEKSEDQPAAEEQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLW6</accession>
    <name>A0AAE0JLW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_134240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685058.1">
        <property type="nucleotide sequence ID" value="XM_062820843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLW6"/>
    <dbReference type="GeneID" id="87857997"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="81" mass="9363" checksum="041D229DDAC62AD2" modified="2024-05-29" version="1">MLSNMIMQGPWRFRFCFPLPVTSFLLSFRVQGWSLLKLRSKQALSHPSSSLYGNFADCMSQAALQTRSVWLHSPHENATMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JME0</accession>
    <name>A0AAE0JME0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_1746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685525.1">
        <property type="nucleotide sequence ID" value="XM_062821418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JME0"/>
    <dbReference type="GeneID" id="87858572"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="179"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="407" mass="43631" checksum="7C7868EFD2CEE2A0" modified="2024-05-29" version="1">MSIAGFPYPFETGGPAYRSKVLVPSEEMDARNSREPDSHTNLISPGSGSGSGAAAAPVMVTAAELGAPFLRLRGISTAHLPPQGTPQQELIPFLTALLRESVPFIDSVAPKPSNRPQPTADLGTARSEWKPLKTKSSKVEDNGNTVVSLYERTLSAPELRAIERSAGMATSNTDDSETWACRRSVHRDSNVPGDGSASWGEFVTCFKDKHVECEEAFTPSIVGTRVLRDYDVAGLQVDDEHGDRYGSFTMKVVEARHKIGVKPLLKDRAFTVLQVTCSLLPSGGGSATASTAGDGGRSEDCDEILVINIPVSDVENLTTSTAAKEDPFRKDTVQGSYVSVERIRKLPTTENDGQAQIEWIMATASDARGSLPGWVQTMAVPGQIAKDVTLFLGWVAKEREKKGGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMK0</accession>
    <name>A0AAE0JMK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_416011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685770.1">
        <property type="nucleotide sequence ID" value="XM_062824016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMK0"/>
    <dbReference type="GeneID" id="87861170"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="10">
        <location>
            <begin position="86"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="10">
        <location>
            <begin position="602"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="902"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3354392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1097" mass="120328" checksum="105D6D90BFE2E338" modified="2024-05-29" version="1">MTAPGRVGRLGHIVGPSTMAFRAAMPARLPLRPSTAVSCPQPLVAASGLRWASKGRSQGKLKRVIPRTAWVQYPELFPVREDFASRHIGPDNSSIQEMLGALDPPVESLDQFVQEVIPADILSKRELFPQNRVRFHSTKKYPTRQGHQEWEIVKIAESMASSNRHSIKAQIGAGYYGTLTPEVIKRNVLESPAWYTSYTPYQPEISQGRLESLLNFQTMVTDLTGLPIANASLLDEGTAAAEAMTMSLNALPASRTKSPTKTYVLSNRLHPQTRAVLRSRAEGFGVNIITLDFHDPEFPSKLEELGDDLVGVMVQYPDTTGQVLEHRQLADLVHKQGALLSVATDLLALTMLTPPGEWGADIAFGNSQRFGVPLGFGGPHAAFFAVQEKHKRKMPGRLIGVSKDRLGGRALRLSLQTREQHIRREKATSNVCTAQALLANISSFYAVYHGPEGLRAIAERCNLGARVLESAAKFCGLQLYSPTGSVVPFDTLVINQDHIGKVLVYAARERGINIRFISTDSAGISVDETTTENDLINLIGAFQDAARSLKTQGRDEALDANPQVIFEHFLKHHVEQIKQSGPLGHLPEPLRRTSSYLTHPVFNTHHSETELLRYIHHLQSKDLSLVHSMIPLGSCTMKLNASAEMALITLPGFSNLHPFVPPDQSEGYTKLTKVLENQLNDITGMDACSLQPNSGAQGEFAGLRVIRKYLQSRAQSHRDICLIPVSAHGTNPASAAMAGMRVVPIKCDTKTGNLDLADLEAKCKQYENELAAMMITYPSTFGVFEPAIKKVCQIVHAHGGQVYMDGANMNAQVGLCSPGEIGADVCHLNLHKTFCIPHGGGGPGVGPICVKDHLASFLPTTKTMSNTELNLPVSSASYGSASILPISWSYNALMGGAGLKKATQVTLLNANYLLSRLKDHYPILYTNEHGRCAHEFIIDARPFEKTSGIQAIDIAKRLQDYGFHAPTMSWPVANTLMIEPTESESKEELDRFVDALIAIREEIREVEEGKQPREGNVLKMSPHPISDIIGGDGEAGNKWDRPYSREKAAYPLAWLREKKFWPSVARVNDTYGDLNLFCTCPPVEDTTGGNQSSIQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JML9</accession>
    <name>A0AAE0JML9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_421264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685403.1">
        <property type="nucleotide sequence ID" value="XM_062824332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JML9"/>
    <dbReference type="GeneID" id="87861486"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3352108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="58" mass="6826" checksum="9ED44E939FF5E501" modified="2024-05-29" version="1" fragment="single">MDPVKENIDKAMNEIHKTWWNHVNGLAEKWANHPDPEAWHKHFLECLDSMEQGPPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN14</accession>
    <name>A0AAE0JN14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FRG1-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_562207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685676.1">
        <property type="nucleotide sequence ID" value="XM_062830194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN14"/>
    <dbReference type="GeneID" id="87867348"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3354298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="290" mass="32309" checksum="5E71631E1E6C7E24" modified="2024-05-29" version="1">MVKPLTFKGDKKAKKRKRPTTETNDDDDAPERQEKQLNATTSSSKTTTTAAAAVAPNEVEGEEHDDSWVSADAPSDVSGPIMFVLPTEPPSALACDATGKVFTLPIENILDGNPATAEPHDVRMVWLAHKIVGTENYRFKGQSKKYLSCDKIGLFSASSDAITPLESFSIIPTFDTPGTFQIQTLRETFLTVRASKSSKANAAPEVRGDATEISFDTTLRIRMQARFKPRIKASKEEKAREKISRRELEEAVGRRLEEDEVKRLKRARREGDYHEVMLNLKVKGKHDKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNE7</accession>
    <name>A0AAE0JNE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_562324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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            <end position="603"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825855.1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3354114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JNL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686277.1">
        <property type="nucleotide sequence ID" value="XM_062829273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNL7"/>
    <dbReference type="GeneID" id="87866427"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="128" mass="13447" checksum="69F7A6F7F839B25E" modified="2024-05-29" version="1">MDVRSGAAADEAALQSLAGLWILGCSAEEPAAWMTESNSGATPAAQSSWSVLDVANRRKTWPRTKLGVAWTGAPRTLSKAALQGQKLPMSNFSTGADEALQAPGRSHGEPTTQEAKKLLPVSDWASVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNM1</accession>
    <name>A0AAE0JNM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_437844</name>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685876.1">
        <property type="nucleotide sequence ID" value="XM_062825338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNM1"/>
    <dbReference type="GeneID" id="87862492"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="111" mass="11722" checksum="467AC84E7103DB88" modified="2024-05-29" version="1">MQRGPTGNPNFSVTSWCSIIPASVGRTKGLRGGHSANSGSMLGNVLGAWLVLSWLSFVIPDGGWYGIGTRTGRQPEDAICNSSHTQPVKFPVVIHGESHGKGCWSSNGEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNQ8</accession>
    <name>A0AAE0JNQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_449997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686260.1">
        <property type="nucleotide sequence ID" value="XM_062825984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNQ8"/>
    <dbReference type="GeneID" id="87863138"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3354882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="166" mass="17928" checksum="5868353A9894B658" modified="2024-05-29" version="1">MSALKAGDSFPEGVTFTYVAPSGDTDLTVCGLPIQYDASKEFLNKKVVLVAVPGAFTPTCQQQHVPSYLAKLEEFKSKGVDQIVFIASNDAWVMAAWGKANGVKDESILFMSDADCKFSKTIGWTQGDRTKRYAIVIDHGKVTYAELDEVPKSIANTGAEGVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP68</accession>
    <name>A0AAE0JP68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_451005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686544.1">
        <property type="nucleotide sequence ID" value="XM_062826031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP68"/>
    <dbReference type="GeneID" id="87863185"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1090" mass="127668" checksum="4D8E74E3C37D58B7" modified="2024-05-29" version="1">MADQGRYRYPSVAPPVGRRSPTMYNPARLSMPITGAGTYQSLYGGEIPVLPTTHETLPLRSPVSATADYRPSTIPIDSGSYAVRKEPIPRSMSVKDHGTRSHRSATLDAASKRPVIKHAPESPVPSSIRSGSPSRPVYRASDEFYTQPASSINRSRSVARAPFSANMDDAEYQRLRERTDRERMEHERLYGSRAADLYRASRPTVLYSNTPRAAPGYDEEAFVEYTRPGELARYDLDHPRRSRRESIDHYYRPAVSVSSDVGRPYDTIDKRLYDPPPSAFGYDKPGRDAISGLYDHNSVRPAPSEVLSDTAVRRPPALLDSPLPPGSSATTKRTSRRAASRPRPISLIQETPSRSAHPDEYYRARDDGYYKVDDVSQRGFGIRPAAKDHEERQRSPREKQYYDERRDPREPRRRSDEDLEVVRHRNHDDRDRRDYHKLPPTREYLPVDDREARRDKHVPVNDISAATAMTVASAINGRDGRGDRDIESPRRRYDEDYERRDPDPHPRTSRHAEDYERRRVDDPEPRRLPPKDDDYDRRRSDVPETYSRVSCNDDDYDRRRADDHEPRPRTGHRDEDFDRRRDDDLEHRKQIDYKDQGHDRRRDDDLDHHKRADYKDQDYDRRRDDEPESHKRNDHRDEDYDRRRVDDLEPHTRTAHRDEDHERRRIDDSEPHPRDSHRDRDYDHSSVDPRDSHKRDSRDEEHYERRREADNPEPRTRPSREEDHYDDRRVDDSEPRVKAGRDDYRRSHESFQMVDLPGGFPSERDERETGDETDAESRGRHRRDTEAKLNGEPASSPPREHSREHSREHSRERDDKDDETHPRPRPSSTFDPNDTAGLEELKAELAAQEAKENASEGDRTPKEHSPERKPSPVEEDSKPSTEADNTAMAGNEEDESRGRELVPHGQKQVRVVSPPREKEEKKPIKGILKQPKAQFPEHPNTVREGVSPHKDDKTKQSVPQGAKWTKINRKLVNPEALTLGKERFEVRDDFVIVLRVLDKADIQKYADITAQLREKRRKEYEDEQNGKALVHHERNGSYDRDEEESKRRRHHRKDKDELEDDRREYRRHRATDEQDALYDARQPSRSHRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPI5</accession>
    <name>A0AAE0JPI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_505070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686483.1">
        <property type="nucleotide sequence ID" value="XM_062827964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPI5"/>
    <dbReference type="GeneID" id="87865118"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="340" mass="38142" checksum="842F6581F89A57F4" modified="2024-05-29" version="1">MPPVVFVGLLVALYVWKCMMLVVFQNKIIYMPGFPPNSRWELIDNYANHCGGIKWTDERTRAADGTDLAMAVTTVPMQKGKFPTDKKAARAHVYVLYFQGNAASIPPRLPDLSWVLRNISDSHNPNLAPLQITFVCLSYRGYWTSRGRPSEAGLRLDAEAGVRWISQYHEQLYGPGSEAPEPILLLWGQSIGCGVATNLAATGRIPENVPIRGLLLETPFLSVRTMLETLYPQKWLPYKHLWPFLRNHLDSWANLVTIANTAREKGCPPPNIFILEAERDELVPPEHAERLLERCQDLGLPVERVKSPAAFHSDAIMRVEGKRLAALGIVRLTKQALDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPK0</accession>
    <name>A0AAE0JPK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_43751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686699.1">
        <property type="nucleotide sequence ID" value="XM_062825317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPK0"/>
    <dbReference type="GeneID" id="87862471"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="540" mass="59621" checksum="51CA8618D63B90C1" modified="2024-05-29" version="1">MGPKRDHDALTHSDNEEPAPQPVAKRRKEHSSAKSKTTEPKTDSTYGQRAAFPGLDEPAALSDEDLEFEDQGDALAYLRSVRQEANGIPHLLVAPKAGPQLPPYLSNSDSNNNVDRSIYHDGLGDSRGYYQDGAYTAAPDNLLQSVPEDDDNADDYYGHGHGYGGANYDDDSDSDWSTSTSRAHALLATNRHLAREAYFASLMTQFSALRAMLHQTPPPSLLSSLDKEHGYQVGSFGPKSWTFRVWTRRIRYTDPIPAQVAAMDRFGALKLLRVILGGKFIRRGCELRERTSRWIWALLARLPDRGEMDHTDIGWVRELGKRAVLMMVSIAQMAALKEEVEGDLEGQDLLVGDDDGEEEEEEEVLVELEPDTSNEGVGRVEEEEEEEEVSNETEGQAAEKDGVEPATAEDSLAAANLVTEDQGNSSKVEQQRQEQEETGEGEIDMDIDDGEVLDEEGGPDPPASSSKDDAKADIAAAKARLLAQLDEDTAAADAEAQQREDELTRQRLNMRATLNMILTVAGEFYGQRDLLEFRDPFPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPM2</accession>
    <name>A0AAE0JPM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">B0H65DRAFT_450562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPM2"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="160"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="754"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="779" mass="87736" checksum="64987F19CAB5A0E6" modified="2024-05-29" version="1">MGPKAIEKKRKVQDPEPESDDEIAPDFDGALSQSEDEFDSDFDDNEHEQDGEQESGSEASDDEDEEGSLLSDDIPSDAEGDKAMGKLVLEDEEEELKIEIPGVDPKRPEKDDGEKNYRIEKDANGNERYVYDEIDPVYDSDDSDAQEAPNTIGNIPMSFYDSYPHIGYDINGKKIMRPATGDALDALLDSIEVPKGWTGLTDIHTGNPLNLNDDELELVRRVQMGMIPNELENPYPETVEYFTGIEEKMPLSAAPEPKRRFLPSKNEAKKIMKLVRAIREGRILPYKPPEEREKEEEEEEQYFDIWQDEVPQEVNPLHIPAPKLPPPGFDMSYNPPAEYLPTKEEREEWEKLDPEEREKEYLPQKYDSLRKVPGYGEVVKERFERCMDLYLAPRVRKNRLNIDPNSLLPKLPSPSELKPFPTVAQTVFRGHDGRVRSVAIDPTGVAVASGGDDGTVRVWELLTGRQVWSVKLSSEEAVNTVRWRPAKDSFILSAAVGEDIYLMVPTHASVTPALDQASRDILSAGFGYATNGQQHGAAPGKEPPAKWARPGAKLEDEGVLIRITVRSTVKVINWHRKGDHFATVSPSGQRSSVAIHTLSKHLTQIPFRKLSGLAQTASFHPLRPLFFVATQRTIRCYDLQKLELVKVVQPGAKWISSFDIHPGGDNLIVGSYDKRLLWHDLDLSIRPYKTMRFHSEAVRQVKYHKGGLPLFADASDDGTLQIFHGKVPNDQLENPTIVPVKVLKGHKVVNKLGVLDMDWHPREPWCVSAGADGTIRLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPZ1</accession>
    <name>A0AAE0JPZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_28841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686287.1">
        <property type="nucleotide sequence ID" value="XM_062822975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPZ1"/>
    <dbReference type="GeneID" id="87860129"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline kinase N-terminal" evidence="3">
        <location>
            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="782" mass="87645" checksum="12D4EDBCCBE05A12" modified="2024-05-29" version="1">MSAPSSVNGSVNGSVNGSTLHPRRSALKYEGDSDRAHSSGASAKAVQIAEPETPPVEEHHVKKQFSAGVAKRLGGRPAPISSPSRTSLASVTSQADIDDSGSPAVLTASPAPMDESPAHGPQGRHRNKVDRISERLVAQVAEWIQHEKTKRETRKTMKVLRRRKTPPIHVNGEPTASSPTRPRSDSISSDSSEVSLDRLQKILDVGMSALGLDQVPQLGPRLGRRRSRRSLKAPPARTASSDTEFFDGDVVVPSCDVFLDNSKTMSYSGGKATTEDTPSQASRSKEKEKQAWLTFKNEIIRLAHTLRLKGWRRIPLNGGEMISVERLSGALTNAVYVVSPPPESVLPPQEGKKQPEKVLLRVYGPQVEHLIDREIELGVLKRLARKKIGPRLLGTFLNGRFEQYFNSTTLTPENLREPETSRQIAKRMRELHDGVELLEHEKNEGPGVWRNWDKWLDQAEKTAMYLDNQVAAELHKTTRHKETWKTRGFVCGVEWPVFRQMVQKYRMFLEDYYGSPTKIREKLVFAHNDTQYGNILRIRPDDKKSPLLQPANEHKQLIVIDFEYAGANLAGLEFANHFSEWTYNYHDPVTPHLCDTTKYPTLEQQRRFIKAYVDHQPKFPSVPGASTPSVTPSGTGTPRPGMLQSTNSASSIVDFMLDARVPPGGWKEEDARREAESEKRIKELMEETRLWRVANSAQWVVWGIIQAKIPGLTDGAKDVVTAPDGSVPDEELEAEEEADAFDYLGYSQERAFFFWADCVHLGLVTEEELPENVRSRLKFVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPZ2</accession>
    <name>A0AAE0JPZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_544786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686919.1">
        <property type="nucleotide sequence ID" value="XM_062829326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPZ2"/>
    <dbReference type="GeneID" id="87866480"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="102" mass="11555" checksum="61EE8A2426500A2B" modified="2024-05-29" version="1">MGLGGLLMGDLFQWPADPIFYLHHANLDRLWWSWQKRNLTTRLKDISGPSVMIDPTSPPVTLDFPMTLGVSYEQGTIGDVMDILGCKETGILCYDYDKVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ16</accession>
    <name>A0AAE0JQ16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS maltose permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_41755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686641.1">
        <property type="nucleotide sequence ID" value="XM_062824095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ16"/>
    <dbReference type="GeneID" id="87861249"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="65255" checksum="9B78902345D5ACEC" modified="2024-05-29" version="1">MRPRLLLPRGDLARPCSPAIHSTTTRFFTQSASLRVGIRTRPQLGFLNVPVTTQQYRYLTTERKARLKYDIKQGIKITSSLWIAGACCFAIAFALVEETLEARYPTPHEWSMLSRIFFRGAFCERDQTDPSRITDWVHVTNWIKSVVDRLEDPSIDGKGLRDAPSDRPKGTKDISTMSENWRRGYYEAMMLYAKAAENVEKWVTDKTQNLTVPNDYVIGPSNPNPRPFPNEDYRPPQEDDCVPTFESPNEIYMRILSTEGLTNRQRMEAGLAYATWLEFKQITGPANIILENAVDLAATEQASLIGGQSPLDTKTYTLIDTAGHHPSSNLLQSLTALATFRARNGDVSSALPMLVSILQARKTLPTSDPRRIPPLPQKKQTWAGAALALLSEPPYPDAPEDGTLPPLRDAKERCEEAALSLHIGEIMYTAKSTNNTNPSETSAQHHSHHREEGLGWTREAVDIAEEQLRGLSNKQSAMPARHTCRECLAAGLENWTMMVSRLAREEKARKEELERNPDLHKPKKTSWWGFWGQGEHKQEDLNRWAAEEKVIAERQRRAADLLDELPTGNRGFLSFLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ19</accession>
    <name>A0AAE0JQ19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_54580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687042.1">
        <property type="nucleotide sequence ID" value="XM_062829406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ19"/>
    <dbReference type="GeneID" id="87866560"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="314" mass="34803" checksum="2BD0113A48A4EAEC" modified="2024-05-29" version="1">MAAKGYRLLRRPWRVRRPLYYGMVFELLGIVAVLVLFGVQQPDAFRTQFWEIGHLMGWNSSPDMILYAYANYQPLPKVPFVWSQLLTNFNVAISVVSLFILLVKMIMIIMKFYYPVLGLIVSLGLTVLYTVSVYGQAGPDYADPEHPSPVAWYIAKSCSVARPFNAEGNCQIAKGAFGATIYLLVVYLANFILSIWSMWPNKMLDMYDDDEDYDDEQESKPKGKQPVVNVTALHGGIGIMSGGSPSTGYYGNKEWEMQPTQQPPTSPRAVHMSGAMGGGHGGGGGYGGGVEPPLFTPRTQAFHALDRRLPLRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQJ4</accession>
    <name>A0AAE0JQJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_453696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687345.1">
        <property type="nucleotide sequence ID" value="XM_062826160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQJ4"/>
    <dbReference type="GeneID" id="87863314"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="506" mass="54615" checksum="54FFA90299F0BE56" modified="2024-05-29" version="1">MAAEVANSAANGPGTDANPLEIMIRENARKTKLIYSATTTPTDASGTSGRKRLKLDPGLASEDPDITKTGLSLRLHAEYSDVQTLPEAIASKLPAGGPRKKKAKLAIEEAPSKSEEHARKLIEGIPPSKSAAAANSNALVLSRSKPGAGAGASTTRPNAQRNEPQTNSLARRSDVLAQPRPDWHPPWKLLKVLSGHLGWVRALAVEPDNKWFASGAGDRTIKIWDLASGALKLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLALHPTLDVLVTGGRDGVARVWDMRTRSNIHVLSGHTGTVADLVCQEADPQVITASLDSTVRMWDLAAGKTMGVLTHHKKGVRALTTHPTEFTFATGSTGSIKQWKCPEGAFMQNFEGHNAIINTLSVNDQNVMFSGGDNGSMSFWDWKSGHRFQALDTTAQPGSLDAESGIMSSTFDKSGARLICGEADKTIKIWGEDLSATPESHPLEWKPTLARRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQZ3</accession>
    <name>A0AAE0JQZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maintenance of telomere capping protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_453851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687418.1">
        <property type="nucleotide sequence ID" value="XM_062826171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQZ3"/>
    <dbReference type="GeneID" id="87863325"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="524" mass="56227" checksum="8EB61043EE39F075" modified="2024-05-29" version="1">MATKRSKTDPTDDELGELFEGIGDDIAINKSSTPKTKRAPAKPKNDAADRDILAELEDELVSKAPERPHTPRVRDLAAKASPAKRTSTNTPPPAADTSASTRKSGESTASHPTGTFTPSATSSDPHESEKKPAEKPQPAAGSGGSWWGGFLSTAASTAAAAVKQAEAAVKEIQQNEEAKKWADQVRGNVGALRGLVGEDLVHRAIPTFTNILHTLAPPISSHERLLIHITHDLVGYPSLDPLIHGVFSRVMSQVEGGDLLVIQRGQESTARNSSEKPSFFGGSSTVGWRDGPWWRQVEIPRDLGVINGMVEGTKLCRANAEGYANDYFAAHGGIEVARQRAMEPAGESNPVRTSDIFLSVQAIGVKEDKALFAGSSASEKEKESSDVLDEDKIDDLVCFAVYIFDPIHDIQYSAVSQSIPAKWIRWLDAAAAPLTPGSADEGQEFDFERVPEEIRDIVESGGVDPREWVAEWVEEALSLSVGIIAQRYVARRMGVGEGSIGKGKQKVETILEEGGSEAARAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JQZ8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Beta-lactamase superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_57928</name>
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        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQZ8"/>
    <dbReference type="GeneID" id="87867908"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF9">
        <property type="entry name" value="L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="286" mass="30413" checksum="73BC2EB3199E876C" modified="2024-05-29" version="1">MPSTQASFDYPLSITNIGTATALIHLGEPSSPNRINLITDPVFGPGGTQIEYRGLVINKSDSPALTLDQLPPIDAVLLSHEDHPDNLDELGRRLLDGRRVLTTRDGASQLAPRPGVRGLKNWETVCLDLGGEGKARKLEVTATPCKHLPGGQVVGFIVSSPDGAFGTQPDGRPNAIYFSGDTIHLEELGKMKEKYHIAVAMLNIGKATVSLPGGGADGGGPLQITMGGDQAAQLAKDIGADVIVPLHFESWSHFMESGTQLANDFAKAGVEDRVLWLKRGVETKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR20</accession>
    <name>A0AAE0JR20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_565282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687463.1">
        <property type="nucleotide sequence ID" value="XM_062830280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87867434"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38709:SF1">
        <property type="entry name" value="DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38709">
        <property type="entry name" value="SI:CH73-193C12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="3">
        <location>
            <begin position="1566"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1419"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1477"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1632"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2129"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2170"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2290"/>
            <end position="2586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2060"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1423"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1477"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1632"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1761"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1774"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1820"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2131"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2175"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2310"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2360"/>
            <end position="2377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2444"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2487"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2518"/>
            <end position="2531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2532"/>
            <end position="2551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3356086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2597" mass="290149" checksum="9BE43B739DACF6B7" modified="2024-05-29" version="1">MAGHSFKQLVFEQFFPDAVPLPDPEPTMTTSPVLPAPANDTEQPEGEVNAPEPAFSWADEVEEELGEEQPAPVVVPVPDAEDDIENTAEKDDVQVTTIPLPDEAIPAATDVAQPESDFPELESPGSELAEYEHEDGYESCVEDYDGSCTLSQGSDDDKRKLSPIPEETESEGSHDNLILVDNPDEPVEPKGGDQDDVQSTGLQEESSQMFPEDPTAPEMPTDSSPPQLGPESFPPLYVTPDRTGLATIPGPSGGVTPLSAGEGPWRKLGDGERQNIEAWARGEAELTTHVEPDNEAESPDIPALCHVHRSPRSSNSSYDNLSDAPTVIGSHLEDELQDPFQRRLQDEFRGLPEPPMGTMASMFDYAPSSEIASNAPASKDTWRFDDRLTGPTAAANYVLPTLTSSFDKDTFLKSLSGISKKGKERKEKLDMRMKSLETGGRFDIIFELNIRRDYIRMSSESLEELENSEDNISNFAEPLMKQEQASHPPSGNVSEAGNEQISVNDEIEQEKAHSEREPTEEEKAEQIKREKEKARKKAKRQRHKDNKRTEVQTNVRDAESQPGVTTQASEMENATIQDDDEEYDPIKAQISDADKSKMWFNAKNQARDILKKHLKEEEELLEAGRAFDKAIDDILGNPENAQKEVAEAETKAENLQANQDEPEKPKVVEARRDQASEYKTPAEERRKVEQEDADRKLAEQIAKAEGDETTKRAEDAKPRTLDEQQKSEQEEKDRKLAQQIAKAQEEEAAKASEDAESKKVEEAEDLAKSTEAEKAKALRERAKAVEAEMLKELGQAKAKVAEAERLKDSEKEKAKTARAEMDLARKKAEALEAIRRKAVREGKTKVAESHEDKKRKALATADNASIAEEQASEKVKMYEEEENKARENLRLLEIARQDAVKAEKAKAAELGNWNVAVNPRAAAAERRRIIREAEKASMAKTTVEEPPKTFTPGGKITSVAETRGKTLTPGGKWTTAAASKGGASRTRDNKFRPLGKISNIAESRSGAAKDTSRKHVAAGAEKRRELEAAGAEKRKEIKKENQQPGVVKTSEPTVPKTPAASVAKTPEQSIPKPPEANISKPPKANVPNSSEPTVPKTPEASDPKPLTEAEKQRNFYEAKKKQRDEEVRQEEAKQKEKDEEAKRKRMEEEAKRKQMHANAKTASTQQAKEKEAWPNLPSPSQQRKIEGLGNAPPPVKVPQIVKIAPPKEKPQSSPKANPQQKPQSPAQKPQQASTQPKPEEKDQGKIQAPVQAKPQKKAKKQAQVPAAENTQVQSQKKIKDPVPKEHPIPAQEKLQAPAEEKPQPPPQQKHQAPAQENLQAPAQENLQAPAQEKLQAPAQEKLQAPAQEKLQAPAQEKLQAPAEEKTQSPAQKKPEPLSPSRLVQLTNKPKAPVQVQTPATSTKKYSEILSPLERLDALNTAISGGSAQGNSQSSSMSGEKKNEVQEETPYIIPQLRKLFDAKEKEEQLEAQKLEAEKIEREKAEQERITREKAEKAEREKADHNKAEREKAECEKAEGAAISNSRFGNERTLQRWVPDSTDGLDDSLEKTNTSGTWDQFAANERLFGLKKTDYDEKIYTTTIDKSHPQYKERMAAAERKAREIERSAPVTAHVAEERVMDFQEKAEQERVECEKAREKAEQEKTEQERIAREKAVKAARERVALEKAREKAEEEKAEREKAEQERVEREKAREKAEQEKAEQERIAREQAVKAEREKAEHEQAERERVALEKAREKAEQEKAEQERIAREKAEHERAKREKANRKRTERKRVAREKVREKAKEEKAEREKAELEKAEQERVARDKAERKKAELEEAEREEAEREKAKREQAEQERVAREKAERDKAEREEAEREKAKREKAERERLDRAKIEKERLAHEKDEREKSEREKAEREVAERERLKQEKLKAEELARETLEHEELKRHNLAAEKLTREMMERETVEKNGPDDENSEVQKAKPSLESGNTNPQIKEREERVRAGQPISNLGGSEPEREDGLLRINKVRAKRLEMLKSAEEYGEEARRQDQMIKELIHQRDRNLMIREQELQRVKSIFDEDLGKQVSVEDTEVAEAQRKLDAKKRELDAVRAELKAETPLGWVPITVSPAQPNLIQGQEEGKCRSAVDLSGQGAVVGEDHGEEHPAWGHPPEQDQPPSTLSSVSSLFFGFDDRVSTPPAKPQSTLPGQAQPQGSGNQPTEASFANVAIAFQSFRLILSVAIGADWNTAFSVVLFTVSTFMTDSLPLFTALLKFLRFGIHKSAPARLQDITLASGPAYNYQTSPYQSGYQGQMYASQQQMNAPPPELNAPQLGPNVIQPQFNPSQGPTATTASGSAYSHQTSPYKSGYQEQMNAPQQQMNAPRPQLNAPQLGSNVTQPQFNPSQGHPMPQGEPIWVHKDAFPGPQALHPMYPQGNTHRQLYDPKNPSTSYNGPYPPGLSPTRGPRAEASMTPRNPSSTHNVPHQSGLSPQGARDSSHRAPRTQEALPERPAAVSPQNWRTKASTSGHQAAKPEEWPQSLSPNQKKMLDSFKGDGDQREQVASQAPVSEGNIATPSMLPTVQEEAEELEETEKPAEEAVVQGDATTQAEAAGPRMIVIRLPPQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRK5</accession>
    <name>A0AAE0JRK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_452761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687067.1">
        <property type="nucleotide sequence ID" value="XM_062826116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRK5"/>
    <dbReference type="GeneID" id="87863270"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="122"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="458" mass="48612" checksum="A0A82DB33B856F86" modified="2024-05-29" version="1">MASVSALRTLSAPCHTARLRLARSSTLTISPTSSSASYLLLSHNNHNRPAVDGMRYLSTLPPRVGRRIAHQLMTKAPYSTAAEQPASGSGTKFVYNIAASYVGKGRPFNPSTHVFHFNPYHRVSKPGKKAKSARPESGQDAFFVSRVGNKPGEVALGVADGVGGWMDSGVDPADFSHAFCDYMAAAAYENDKQPTKIAAAAANGPQAPAGGDGNNSGNAPLTARSLMQKGYEAVCHDPTIKAGGSTAVVGLLDESGTMEVANLGDSGFVILRLNGVHTASEPQTHAFNTPFQLSVVPPSMLLRAATFGGGLLIDQPRDADVTRHKLKHGDVVIFGSDGLWDNLFNQDILRLVSSTMQKLGAWKGTDAGVQVAEDLTPFTKLDSDDKPIFTLQSFIATHIVSAAKSASMNAKLDGPFAKEVKKYYPQDAWHGGKEDDICVVVVLVSEEPADMAAPKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRR5</accession>
    <name>A0AAE0JRR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_454436</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687622.1">
        <property type="nucleotide sequence ID" value="XM_062826195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRR5"/>
    <dbReference type="GeneID" id="87863349"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3356245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="273" mass="29476" checksum="452F565A2D6E800E" modified="2024-05-29" version="1">MPGFDFSNYNRNAALHARGVPLPKATSTGTTIVGCIYDGGVVIAADTRATSGPIVADKNCEKLHFISPNIWCAGAGTAADTEFTTALISSQLELHSLSTGRKPRVVTCMTLLKQHLFRYQGHIGAYLVVAGVDPTGTHLFTVHAHGSTDKLPYVTMGSGSLAAMSVFETQWKPQLNKEEAMKLCSQAIEAGIWNDLGSGSNVDLAVITAEKTTLHRGFVKPNERTQKLKSYQFRRGTTAVLNEKVIKKEEIGNYVSVVELAEESSGDKMEVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJE5</accession>
    <name>A0AAE0MJE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_512487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676967.1">
        <property type="nucleotide sequence ID" value="XM_062828576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJE5"/>
    <dbReference type="GeneID" id="87865730"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="691" mass="78094" checksum="14F2ABBDB253A468" modified="2024-05-29" version="1">MLEGDGKHFVDIAETDWSTIDTAPKRTTKRPRAAARSQPSNPDTTSSVSAAASPFTQHQPRLPSLRDLFPPEFFQPPTSATMPRRQAGGDEDEDYMPDEEYMPHSKRHKSLTRRASQEELSATDSQYSESQGDLELDEAYTAASYRPNPRRSATVAYDRISQTSRTSRQPHRVEQQQELSHGQQSESRRSLQQNQSVEEQQTSRNRVTCEVSRASRHVHFAGPQQQDHRRAPQSQIASNVPVRPSPLSNMSLLRDFEHPSTELTAASGRPVRGAMARALDRMSNQNQAGSSSAVNPAEEDFRSDAPGRPAKPPISREQQRKQNLIMVLYRSIFDSKLKEFPSLMTFRPIPDTWQEPSSLRAASPAPPPPNTPLNLNNIPQRAEFDAFHQHSLSSTLRMQTPYGGPAVPVPPLGYESYSFQNYPSTHKTNDHEYYSTAANDVFGQAVPSLRTTPKYHPTNEMTPEETQRYHNDRRLFVKMKAAWVDNDKVLRLREQKVDGDALQTLWEVAQVFRARNPVNPSAESVKWFVDKRDEISRPRSQSQRQSQSAPAEESGHDNLEDLVNAAAAAEELEVVGPEPMDVDEPEQQEDDEEMPQQAENDEEDDDDEYVDVDELAPAFRMLQQLEQQQQQQQQPPAASVSPPSIHSQDYDADVDTPSETQSEIEDHERHERARSERAQSKGRLGINDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMB6</accession>
    <name>A0AAE0MMB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_306768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677342.1">
        <property type="nucleotide sequence ID" value="XM_062823228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMB6"/>
    <dbReference type="GeneID" id="87860382"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3337891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="68100" checksum="1A8A9689139506E1" modified="2024-05-29" version="1">MPSTPRRSPRKLASSQGTVIVGIDFGTTFSGVAFTWSNQVDKIETITSWDADSSDNTDECKTPTAMSYDPGNEVTWGYGIEPEKEQLKWVKLLLLNDEDIPEEVRTSDKIKKAREYLQKHNKTAEEAVTTFLRHLWEHSIDCITKSISRVMVNYAQFHIVITLPAIWPSYAREKMKLAAEQAGMLDKRMGVETQLTFISEPEAAAIATLADMEGRFDVKDEDTFVVADCGGGTVDLISYKLIQAEPMIVKACVKGSGGLCGAVFLDEAFKDVLKSKFGKKWEKMEESNRRDMIRNSMEPGIKRNFKMGSDKSYNIRIPFECLLAKERRVTGAQGLPTVTIAPEDVKTAFDPVIEKINNLIDGQINAVKEKERVSPKYVILVGGFGRCNYLYDRVDERFGMEVEVLQAKGAKPWTAICRGAVIHAATQSGIGKLSVQVKTRVARASYGICWNEPWDSRRHDPEDKYWCDIEQKYYARNQMAWLLEEGDDISAQEPTSRSIKQNFDRNGPMRTPEDEEIFQTNIFPPPTRWDPEVIKELCSIKWETVIDPYTLPKFTNRIGRVYGELLYRCEMTCSGESVGFAIYRDGKKEGSKSVKVDYNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMY5</accession>
    <name>A0AAE0MMY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conidiation-specific protein (Con-13)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_311446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677496.1">
        <property type="nucleotide sequence ID" value="XM_062823305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMY5"/>
    <dbReference type="GeneID" id="87860459"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042092954" evidence="2">
        <location>
            <begin position="21"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="344" mass="37455" checksum="01D922967089CDAD" modified="2024-05-29" version="1">MLQAPFFALLLAAVVPAVLADGPPETMGENFSGLSVLDSPGGLQSLTPAPYTKSQWPWGTVPKLCYDTAVNNKYCNPYDLEVYDVTYSDCPIPTTVCRCNNSPMAIDTIAQRVGQLPVKARQWNGYVSSFAGDICSAYSDSFHNYFFGDCGNSESVFFHELSHNLDRHVAGASINDWYSLSQNWKDTVTKGTCVADHYSKSSWLEAYAQVGVMAGYHGTVQSIYTKNVSCMVDQVNKVVGQLDSLWRKKPGQMCDRYWIKDTTVCMGPDAEASGNCPAFRAADAAEVDGVGAVKVPVLPDEKQKKHDAVVKELQHHAEVAAGISPGKPAAEKKTKGKKGTKFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNH3</accession>
    <name>A0AAE0MNH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_433244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678051.1">
        <property type="nucleotide sequence ID" value="XM_062825056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNH3"/>
    <dbReference type="GeneID" id="87862210"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="248" mass="28607" checksum="7ED86C9174A8FC3E" modified="2024-05-29" version="1">MDVSASSSTSNHEALIRSWYLHDGQIKIPSLSETDNFIVLSNKDARSETEVITFLSDKDGQKPTPLQLIAWIQQEHPLIHNPAWAQAYLPLLCPTGITLEEVQKHFQYFNKSNMTKSKHTNTMHKSFDLTSKKMAFHLGYTLQVFWLLVRRPCPPVADQPAHFSNTKPNIRHLAHFFGMLLRVMRDWEFVHLSAEEDAWFGISSDGPGKMSPLALGLKEAERVQRHWEKEKKWVDPMYPAEWEGWAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNW6</accession>
    <name>A0AAE0MNW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_291102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678501.1">
        <property type="nucleotide sequence ID" value="XM_062823014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860168"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF261">
        <property type="entry name" value="BUD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="250"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1551"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3339141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1608" mass="178171" checksum="2A48C1587082B9C2" modified="2024-05-29" version="1">MVRVTEELAISPEHVTLYYTTDPLLGHLPVLIFHGPSTTANYTLNSSRIQVHVYSPAGFMSFHRITISPNSPFYDVVDYLPREFQGDEICRGLAFGLYKYFSELPEAVKAYLKHQYPTRGPRAPDTAATLFSPQHAADLAKSAVPAENTADVIQTLEFALQSQHIGNVDIDLVLPPGSIIPLDDEELEEVPEDEDDILDPTLRQYGGYTPLVKLFGEPVFLPTSKLRRAPSRPASLRNRTKSFSRNQKVDLRMKLGELVDTEERYVLKVNELVNHVADEFRQGAKARATGSISPSEEDLDKLFPPSADEILQLNTAFMHELRRIMDDTEEDAIRDMETPFPIHSRGEGSVKVKDPSGALAMARLFMEWFPKFTECYQDYIRASREFPRLLNLFLEQQSSFRQRVAQKGEQAVRSLLIEPVQRLPRYSLMIDQIVNCLPITHPALQLMLRARDIITNICSLDEGAGDKPHVINRLRAMVECWPPDLEPQGRLAVAADFIELSPPFDDLQESDLQENAGIFLVFSDIIVILKKKTDSGLTGRDLLREIDKPSPAGLLASMTNVAGGAGMWEFALTGWHNLADVRFTESADGRLIWMASTADMKGSHSGEYFGGKAITSRCFLLQEMYEGRASKWSEEIIKARIEGRFSEQEREDPTWTLRSVRMEENNFRLHAAVFQEAADQLIEGRREPAPIRVVLDMDLGTKSAPVGHYGVEVVVEIRTADLRRISMNTLGLNGKKFSDEVALDDFLPTLSRRIIQLLSTQTCVANLRLAPALVNYYTKILRGLHMGSKDIEKGHKRSQSASPVKLLSNFLGGSTPSVTLTESTPNGSLNGSLRGHRRDPNGSAPALLPSQMTRTNSRNDLMLLAASIKEQHSIKLGTADDMRPENPLFRLEQTFTGFIANLQARKGYYHGRTLLTRSMADELLVNDLYNRLIEFPFDLEASAEVGTDIVFAAFEKFVRIAWRDQIGPIITMHALDALVVRASKRVVGDFGDFVRFIFRDLAPQNRRAFTALIKLLADLLDGCSNDGDRGALTLAFAELLVDDGTGSNYINLLDRLVEDCDRIFEDHSFGATLQLNSSHDDITASNRSQKSITGSVTSNSSSLRRKFGFDNLLRQNSKTESGDRSSVWRSLSKHTRSPGESSSLSKASRSKSIDISVFFNPPTPNRSRRPGSRNRPPIAGAFDDITHRPSSSKRLETIGEPENEEASPGSKRLKKKRRSSLSDLKSILSSTTLVESVTSPPPVDDKESPLVADADTAAAPVPAQINRKQASQKFNTAPRLPAPTKIPISPNSPTKIPISPGSGSNISPGTELTPPLYASRQKESPSVSPLAPPPCTPPEKETFSSSLPVRSRPKALSVSQIPTLKPSRLPTAERPSSNNNSTSNSATNNGGSLTRSLSRPALPYNNGGLKTPTSSSGRLGLRAPQKLRERLQTELKAVEEVDATLQSELSRISEDMTRINATLPRSASTEIRRLSSAVRALEERVPQAMLDLQERQAEMNREMEATLKAAEAKVKAIDQLYKEATAENELLYEKFNSELGKMLKALKGKGREDKEELLAKLREQSEEAARVKKENARLKREMASLRALVKAGVSNSSTPPVGMEGLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP39</accession>
    <name>A0AAE0MP39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_252571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679172.1">
        <property type="nucleotide sequence ID" value="XM_062822494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP39"/>
    <dbReference type="GeneID" id="87859648"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF5">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042283770" evidence="2">
        <location>
            <begin position="48"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="60"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="391" mass="43939" checksum="6B8967A86C5AE211" modified="2024-05-29" version="1">MMLLAMTGNAPKHGSAGSGFFTKRPFSLFHSLCLLVIALAFSGQVLADCECGYQSDNLDGVYQNVFTDLIETNFARMPDISTNTDWLRQEFNVTKSKARGEYGEMFYINDDVEYVDNIGNRASDGVQLIVRQDLVDGMVPVAEIDTARLDLSYGTFRASMKLTATPGTCAAFFWYFNDTQEIDMEFLSKEFDHSKNTYPVNLVLQSRAAAAHGYDASQTDNFIKANLPFDPTADFHEYRIDYNPSEILFYADRELLAKMNGSNVPSPTSHGHLILSHWSNGNPKWSGGPPKQDAHLVIRYMKAYFNSTDPKRTQDWSGRCKNAKAQTSVCKIPVVTRENQTAKDYFFSDYPDKAKNQTVYEPTSGARTFEAVARWTLMVILFMVGFAGGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP55</accession>
    <name>A0AAE0MP55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_591686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678771.1">
        <property type="nucleotide sequence ID" value="XM_062831106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP55"/>
    <dbReference type="GeneID" id="87868260"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062822586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPA1"/>
    <dbReference type="GeneID" id="87859740"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAK3340410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="164" mass="18015" checksum="DBBCF061DCF0AC09" modified="2024-05-29" version="1">MMGNAQQARIPSTWGSGVTQCPPPFSVLFSRVSRLDTWTDADGTPHLIRFGFCSSSSSVVLGQSPRTNGTTGPEQAAQKHPTFCEMHLDGWTGTFSTPTRPPFLPLLHFFYPAGGSLPTSLARRIWTASSLLILGFFFSLPLLLSSLRPSPKLHTHTRLDSQWL</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679577.1">
        <property type="nucleotide sequence ID" value="XM_062831077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPI0"/>
    <dbReference type="GeneID" id="87868231"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_254352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679236.1">
        <property type="nucleotide sequence ID" value="XM_062822529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPM2"/>
    <dbReference type="GeneID" id="87859683"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12674">
        <property type="entry name" value="RRM1_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12675">
        <property type="entry name" value="RRM2_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001366">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034805">
        <property type="entry name" value="Nop4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034806">
        <property type="entry name" value="Nop4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="343"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="514"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="653"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="655"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="774" mass="87355" checksum="1CE4C20E8BD1BC64" modified="2024-05-29" version="1">MGKDGNKKRQREVDEEIPVDPDAIKDSDVAAHHPPSKKARVESNRSLFIRQLPPSATAESLTEFFSQHFPVKHATVVLDPKSKTSRGYGFVTFTDPEDTLEAKAKLNNYLLQGKRLKLDIAEARHRDAKKTGPVVSKVAEEKQKRAEAAAEAQKPNKLIIRNLPWSIKKPEQLAELFKPYGKVRFADLPNDKGKLSGFGFVTLRGRKNAEKAIEAINGMEVDGRPLAVDWAVDKQTWDQQNGGKSDDKKEKKDTKAKEPKEPKDKKTEEEETAGMTQEEKDLYNFFKSQGENLESEDEEDEDKDKEDDEEDDEDKDEDDIEEDEEDEDKEEEPKPKRMTDNSLTLFIRNLPYTTTDEQLKAHFTQFGGIRYARVVKDKATDRPAGTGFVCFFNEEEMKTCLKGAPRHQPAPTLAKHSVLQDETVDPEGKYTLDGRILQVAHAVSKDEAERLAEASAGKKDKDKRRLYLLNEGQITPSSTLFKVLTPAEIKMREASANQRKKLIQSNPSLHLSLTRLALRNLPRNISSKELKALARQAVVGFAKDVKEGKRAPISKEENSRGGEQDKENERLRKLKGKGVVTQAKIVFETTTGTKVDEKVGGGKSRGYGFIEYSSHRWALMGLRYLNGFAVKNELGKTQRLIVEFAIENANVVQRRRQDEEKQRTMTPAERKAEMEEKKRSKEAKEAYKAGRKADRKKGNKPEKPAGWNKGKDKKGPAEVAKVAGAAPAKEVKAEDIKVDKKGKKSEEAKEAMMTKILARKRQQRKKKANVRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPQ4</accession>
    <name>A0AAE0MPQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_444799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679802.1">
        <property type="nucleotide sequence ID" value="XM_062825703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPQ4"/>
    <dbReference type="GeneID" id="87862857"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="541" mass="61941" checksum="107165F637CD6794" modified="2024-05-29" version="1">MRRRLLLTVPRKKNVLVTMIGLGKYLNHQRQNLAVYFQRQVESQSSTQILAVCLNAKLYPNPQRLCGAKTRGTPPWTPRGVHGLQNSDQSKTITAALQSNLRAIIERSDVEQLKFRDYVMRHRDFSADEQAALNIDSVASFHEVWSVTVRSKIATEECRKRGSKRVGQFAQDFAVAASDIMGYMGPILNLIRDIGAPYGGMAIGTVSFLFAVQKSIVKVRKTGEEALNKNVAMIKDEVQRFSHSELHDASARDRLSVLRRLLGLQVYEAKEKNYELLLEYEADHEYFTSDGNKRLEIMDETRIEKLQKDQRWVDWHISPESSLLFLVGYNHDEGFNQCWLSPAAIHLVKTMHNEPPSDTDIYAFYVLGIRPGQRNGEHLTQVLAHIMIQLLSQHLWALQDGDKWDDLQAASEEYATVVATAMKDPKNTFRTPKNMEIVQTAALKVLNMFSHKRPEEQKTIWIIIDRLDRVKEPQVRLLEVLEYLVENAKVKVKILAVVSGWDWKRLPSHIASLAEKRDEGVIVYEVEQTRSKRSPVSIMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPV8</accession>
    <name>A0AAE0MPV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_474318</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679952.1">
        <property type="nucleotide sequence ID" value="XM_062827239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPV8"/>
    <dbReference type="GeneID" id="87864393"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="871"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="264"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="608"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="935"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3341010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1178" mass="129274" checksum="BC65C7B9BBB5BA96" modified="2024-05-29" version="1">MYIATVGFIYSGEHISGKIREHYLESCMRQNIGFFDKLGAGEVTTRITADTNLIQEGISEKVGLTLQALATFFAAFVIGFVSFWKLTLILLSTVVALTLVMGGGSRFIIKFSQQNIAAYAAGGSVADEVISSVRNAIAFGTQDRLARRYDAHLTRAEYFGFRLKGSLGVMVAGMMTVLYLNYGLAFWQGSRFLLSGDTELRKILTVMMSVMIGAFNLGNIAPNLQAFATGLGAAAKIYNTIDRESPIDSSSDEGAKLENVTGTIRLENIKHIYPSRPDVVVMEDVSLVIPAGKTTALVGASGSGKSTIVGLVERFYTPIEGKVYLDDVDISTLNVRWLRQQIALVSQEPTLFACTIYDNIRHGLIGTKWESESVEQQRERIYEAARKANAHDFVTSLPEGYETNVGERGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALEVAAEGRTTITIAHRLSTIRDAHNIVVMTQGRIVEQGTHDELLEKRGAYYKLVTAQAIAAANEMTAEEEAALDQEEEAALIRKATRNSQKEGPAGYVEDPEDNIAQKLDRSKSQQSVSSIAIAARKKEKPKEYGLWTLIKLIASFNKKEWHMMLIGIFFSAICGAGNPTQAVFFAKLISSLSRPIVNEEIRASIKSDASFWCLMYLMLAIVQCLAFSIQGWLFAKCSERLIHRVRDMAFRSFLRQDVEFFDRDENSAGALTSFLSTETTHVAGLSGVTLGTLVMVTTTLIAACTVALALGWKLALVCIATIPILIGCGYFRFWMIAHYQRRAKSAYAGSASYASEAITAMRTVASLTREQDVLQHYKDSLAKQQHASLISVLKSSLLFAASQSLMFLAFALGFWYGGTLIAKHEYDMFTFFIVFSSVIFGAQSAGSVFSFAPDMGKATEAARELKELFDRQPTVDTWSNEGDSIKQVDGTIEFRDVHFRYPTRPEQPVLRGLNLSIQPGQYVALVGASGCGKSTTIALLERFYDPLSGGIFVDGREISSLNVNEYRSFIALVSQEPTLYQGTVRENIILGANSDVTDEQIKFACQEANIYDFIMSLPDGMNTMVGSKGALLSGGQKQRIAIARALIRDPKILLLDEATSALDSESEHVVQAALDKAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVEQGTHSELMKKNGRYAELVNLQSLEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ18</accession>
    <name>A0AAE0MQ18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_542068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678680.1">
        <property type="nucleotide sequence ID" value="XM_062829197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ18"/>
    <dbReference type="GeneID" id="87866351"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="704" mass="79287" checksum="AA98B10FFB9360D4" modified="2024-05-29" version="1">MDQAASIVKEHHDVIINAIKSVVQRDWRILIVDDVSKKIIDNSVKEDDILNVNIANIQQIEEPRDENSGMDAIYILSPRPHIVECLILDLAKGRYNNSTVLWTGILGGELRARLAAAPQKIDSRPLLIDFFPRESHLVSFKDPYSFPILYNPSCEAVAMPHLDALAQKIAAVCITLGEYPKIRFFAPRNNEYRASALCGRLASLVQDELDAYKQFKGDFPPQTTRPQGYLLIADRSMDLMAPLVHEFTYQAMAHDLLPIQDGDKVTFHMTVNEGTPEAEEKDMELSDKDKVWVENRHRHMKDTIEKLMSDFQNFIKQNPNFTNQTQDTTSLNAIRDMLAGLPQFQEMKEAYSLHLTMAQDSMNIFQRRKLPDVASVEQTLATGLDEDFKKPKDILEQMVRLLDDEAITWVERLRLIAIYVLYRDGVITEDIDRLLSHAALQPAEKVKITNLQHLGARPTRKLKEERKPHPPLFPRTQVKNPADEENFLSRFEPAVKHMLEDLFNNCLDPATFPFTRPPADGGAADAAALATGGSLRSAAPRWASANRRQVENRQRVIVFMAGGATYSEARICYEESEKRNRDIYLVSSHMLTPQLYLRQLEDLSMDRRRLGLPMDRPQPKVPEHFYAKPKPPPQPMQRPPAAAPPGAGSVHPPTQAMGAMTINSGAAPPHAGGSGARPPAPPAGKPEKPVKEKKKRNLFGLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQA4</accession>
    <name>A0AAE0MQA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_578438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679564.1">
        <property type="nucleotide sequence ID" value="XM_062830728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQA4"/>
    <dbReference type="GeneID" id="87867882"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="256" mass="27441" checksum="20242AB84D9DD216" modified="2024-05-29" version="1">MCIRVLTIFKCACPHRNTLVCPHHIHVREPSSTANLSSQPSPPNPSKPDTTSSSPPSAESPETNNTTDGDMDDDFQKGFTPRLPSALQGHKAWTPLPGKENQRWEHCPGYLAKCRALAVASAGSKTGEVIVGKETQCAEYKATEPKFRRRWEVKAGLCEECRGMHGMDGPSGGQDGEKGKEGGKGKERGVGKGMREKKEEERGRARARSRAATDPTPTVGAVVPVPGLVDGGGNVVKGVSAKVVGRRVVRKRIATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQQ2</accession>
    <name>A0AAE0MQQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_495715</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Vacuole membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="17"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680406.1">
        <property type="nucleotide sequence ID" value="XM_062827789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87864943"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000446">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000487">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="19">
        <location>
            <begin position="1291"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="2065"/>
            <end position="2380"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="20">
        <location>
            <begin position="2460"/>
            <end position="2492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3342613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2492" mass="283167" checksum="52A904C26EFF96F3" modified="2024-05-29" version="1">MSLTKEQAAATLETYIRDVRNRTSTDDARKRAARQIRDLVNVAKQGKSPYPQFLLRFSSEMGAEQFTAFFNTVNQRTMALIQGTDTCDRMGGVYILDALVDFDGIDLALKYSRFEQHIGYILRSKDVTPMQPAAVVLGKLCKPGGSLISELVDAEVKLALEWLQSERVEERRYAAVLILRELARNAPTLMYPYVNFVFEQSWIGLRDQRLLIRATSAETVSACFKIIRERDQAMKQEWMDKMFHEANRGLKTNTVESVHASLLVLKELLEQGGMYMQSHYGEACDIVFRHKDAKDPAIRKTVVLLIPDLANYAPNDFASTYLHKFMIHLSHMLKKEKERNDAFLAIGNVANSVKSAIAPYLDDVLIYVRDGLSIQSRKRGSVDPVFDCISRLAVAVGQTLSKYMEALLDPIFACELTPKLTQALVDMAFYIPPVKATIQERLLDMLSKVLCGEPFRPLGAPHPNTLASIPAIPKDPKDPSVQERGKAEVKLALNTLGSFDFSGHVLNEFVRDVAIKYVEDDDPEIREAAALTCCQLYVRDPIVNQTSYHALQVVADVIEKLLTVGVSDPDPNIRRTVLAALDERFDQHLAKAENIRTLFFALHDEQFAIREVAVSIIGRLARYNPAYVIPQLRKTIIQMLTELEYTDVARSKEESSKLLSLLTQHAQDLVKPYVNSITEVLLPKARDPTPSVAATVLQAIGELCTVGGESMLAYKDTLMPIIIDALQDQSAPIKREAALHTLGQLASNAGYVIKPYLEYPQLLEILQSIIRGEPQHGTLRQETIKLMGILGALDPYKHQDSVASQVANVASARSGNPSDKTPGSLKNALTNLMQVEERTDDNKRNNEAAQLTDVSLMMGGLTPSNEDYYPTVVINALLQILKDQSLVQWHGNVVDAIMSIFITLGLKCVQFLDRVVPAFISVIRASSNARLEFYFNHLSRLVSIVRQHIRVYLKDIIDVLQEYWHTTLALQSTILGLIESISRSLEGEFKIYLAKLLPLMLGVLEKDVSTKRQPSEKVFHAFLVFGSSAEEYMHLIIPVIVRLFDSHSQPLFLRKSAIETIGKLSSMVNLNDYASKIIHPLTRVLASGEPSLRVAALDTLCALMLQLGRDYLHFEHTVDKAISMYAIQHSNYEKAIEKLKKGEALPPNLAPRFEDISMEGFAAENNPPKKLTLNPVHLKQVWETKGKSTKDDWHEWFRKFSTTLLTESPNHSLRACASLASNYQPLARELFNSAFVSCWSELYEQFQEDLITNIENTIKSENVPPDLLGQLLNLAEFMEHDDKALPIDIRVLGREAARCHAYAKALHYKELEFLQDHNSGAVEALIVINNQLQQSDAAIGILRKVKTYREGIQLRESWFEKLERWDEALNFYCQREREIPEDQPVPVDIVMGKMRCYHALGEWDSLATLAGKTWANSAPEIQRRIAPLATTAAWGLGKWDSMDSYLQSMKRFSPDRAFFGAILALHRNQFREAMTCIEQAREGLDTELSALVSESYNRAYQVVVRVQMLAELEELIVYKQTDGEKQATMRRTWETRLKGCQRNVEVWQRMLRLRSLVMTPQENMHMWTKFANLCRKSGRMGLAEKSLKQLIGTDSSLDSVIPYWHDRHPGPVGSRIASPILYAVLKFQWEIGQSPGFRNSEHRVAEKTLYCLQRFTQETAHRVEASRMHMTAHAQNGMEVQNQPGFAEFNEEMLHPQAQKHWLEQTVLLAKCYLRQGEWMVSLNKDDWQQRYRGEVLDCYYKATHYNNKWYKAWHAWALANFEVVQYLTANREVDVRNNGEQHYIIQYVVPAVRGFFESIALSSGSSLQDTLRLLALWLTHGGHIDVHNAVTEGFTRVSVDTWLEVIPQLIARINQPHKRVQQSVHGLLADVGRAHPQALVYPLTVARKSWHNTRRVRSANQILESMRQHSLRLVEQAEIVSGELIRVAVLWHELWHEALEEASRLYFGDHNIEGMFATLEPLHELLEAGPQTLREISFAQTFGRDLSEARDWCRQYQETQDSNDLNQAWDLYYTVFRRITRQLPQMTSLELAYCSPNLLNAKDLELAVPGTYRSGQEVVRIMSFDATFSVISSKQRPRKLDIVGSDGKTYTFLLKGHEDIRQDERVMQLFGLCNTLLANDSECFKRHLNIQRYPAIPLSQNSGLLGWVPNSDTVHQLIREYRDSRKILLNIEHRIMLQMAPDYDNLTLMQKVEVFGYALDNTTGQDLYRVLWLKSKSSEAWLDRRTNYTRSLGVMSMVGYILGLGDRHPSNLMLDRITGKIIHIDFGDCFEVAMKREKYPERVPFRLTRMLTYAMEVSNIEGSFRTTCEHVMRVLRENKESVMAVLEAFIHDPLLNWRLTNPTSPPGPNFNAEREVAMPGAPGPRARRPSILDAPVAPTEFLAAQAAPGADGHGMGMSANPGRSRARTNSSAIYPTGSSMVNGHGNNQQEQQEVQNARALEVLDRVQQKLTGRDFKPHEELNVTDQVNKLIIEATKLENLCQHYIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR82</accession>
    <name>A0AAE0MR82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_230262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680584.1">
        <property type="nucleotide sequence ID" value="XM_062822169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR82"/>
    <dbReference type="GeneID" id="87859323"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042128130" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3342791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="32114" checksum="C4565FFA5A15ADED" modified="2024-05-29" version="1">MICSTSSISTILLYLAVQARQVRADPNAPCYFPGGEFAPGYFACQAFNAPVSSCCPAGWTCFSNALCIATTESNSFPNLTLGAVQRGACTNPQWNNNICGSACLDSENRKGGLAACGNDRFCCAGDFNEGKCDCSSNNKDSGAFTISAGLAQTIIQVSDTTFTGSPSLNIASTRASTVKASATGTGTITTQTASTSGSVTSSPKSTSGQTSSSAPTTTPAAPPVASSKGDDDSDSGSSSSSNGLKIGLGVGIPIAVLAVAGALAYFLWWKPRQIERSRRISQHDHYFQSTDLAENDPHGPAKYEPYRQAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRC9</accession>
    <name>A0AAE0MRC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_187723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681483.1">
        <property type="nucleotide sequence ID" value="XM_062821598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRC9"/>
    <dbReference type="GeneID" id="87858752"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="167"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="239"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3344870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="363" mass="40349" checksum="2472BC54E721FD55" modified="2024-05-29" version="1">MIHSDSDAPTLVSSTKSVLHPSLLQSESMTALATMVGGNKAVMKRNTRAFVGDKIEQALLGPQSEKMTKEDEKADVEPHRKGSIGTSTNQSSRSSRQTSLECSPMTATTSLDTDLSDLSKDEHFSLPDALRDIEPPHAVQAYSHSAKAPLRPNPTLPLIPSDGRPKNFGVVVPGVYRSSFPQSEDYPFIEGLKLKTMVTLVQKDFPEGFDAFLSRNGIKHHVFDMKGTKKEAIPITTMKAILRLVLNQANHPLLIHCNHGKHRTGCVVGIVRKTLGWDVNNILEEYRSYAEPKVRETDVNYIQGFEMAQISNLFSKDMTLRRFGSPKFAHSTVVAIIFLLFWYHFSGISLPTSEAMDRKLLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRD8</accession>
    <name>A0AAE0MRD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_442366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825573.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87862727"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF1996"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3344900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Neurospora</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062828874.1"/>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MS80_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">HbrB-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_442767</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3345383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862747"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
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    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="559"/>
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    </feature>
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            <end position="969"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1149"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1358"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="77"/>
            <end position="90"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="126"/>
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            <end position="138"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <end position="165"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1358" mass="138411" checksum="FFB26B15DF849E2D" modified="2024-05-29" version="1">MQPTSGRGTPGPTQRAPGSFSPLPASTNSTGGVDVRPHRPSPGPVRMISASSSSNDDLTPLTIPRTTNQSTAPSPQPGGGPGASGFGGKAGASPERRGGTTPTHATPIYSSFTSQSNSQSTPSLQTNFSRPTLSNTAALSAARSVAGTHSPIDTPPRNGPSPLTLPPTSATSSTPTSFSGRVGAHSRKHSANAGLFEPTLPSTSTSNLGQIQADSPKLGPTPSQAQRDMSASHIAAQAAVSKSQLSQQQQQQQQQQQAPPYAHQHLLHLQHRQRSQTIPPSTEHHEQTPVANKRMSGGPMSPPVLSLTEASAPRDNVFGSQGYHNGLPGNHTLAATAAANVVFPRSAQSSPKLPTQSTNPLTPTPPPVPAEKPVVKSEKSKVKLFSRPGKSSSKGESSKDTKPLPSPGKLGHAFSNLQRANYSTTSLESNMQQPFYAHGNSSTATIRPAEATEKEVKEKEKKHGHFLKRQKEKLIEAYHLPLSSASSNSRPTDPTAPSSLYNFNLPTSPGPSSNAFKSGLDLRHGGRALREKKNKEDKSLDEAASSYNPGGDWPGPSSVSSATGTLASALFHNEPFDSQKFGLNNMTLDDAWPFLRAKLLVIFEAEDLRLPVEDLNRIVTMHIQYCIKRRSPNIIIEDIRDFLTTGFSSLDQSLKKTQEDRLIPALVELWIFTFTSILPYLQAVFLPLDMEFAGNGPLMTPDQARDFWGGVPASYGVSIPALSVLDIRRLVLLSFRDIVIVPRYDTLKTMFSRLSLEFLPQNLASMALSSPVPVSTSGFQNTAHNQGGVYQSALSTSPSQESQLSLSFAGSLPATMTLGMGAGFGTAPPRPNTSMSNPVGAMDPSYASYSSNGMGMGMGTAGGDTTPGSGNRSRAISNVSFGSDHGNANRPFTPSSIQALGAASAQAAMSTPSGVGIANLNLNMSTPVQQFPSHVAPSIKSIGSNSIHGSLRDPTGGGGGKTADQNVEDSKQVTEMVGRMLQCMSVLASVSAPTTPSFTSSSSSSSVPNNNPHSSTGNLTYNTNNTYSSSQTSVATTTMTNATVPASPSSSSAAGGLPPLVQTMSSPSQFSSPPSPATPTATSPGPLPLRPSISSLSASLAGSFGGIGNSSVPNTPTGGTAPFSHATTTAPTNTAAGGIGGNGGPPDESSRMIEELNKLLKLNWLGRGRTGRNRRGIVGGRVKRAGAGSGSGSALAFSMGAGSGMGYASSYGGYAGSLGTGPGGVSMNSLGTTGTMGGSIGTVGSGFGGGLQGQADRDRGTTGMGGTGLGLGSSVIGTATAAAAGGGISSPPTGGAGGPTAAVPATAGTVGGAGTVGAGAALAGPAGAAMPTAGGPSVGAGAAAGAGSSSNSEVVVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSX4</accession>
    <name>A0AAE0MSX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_166857</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683208.1">
        <property type="nucleotide sequence ID" value="XM_062821311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSX4"/>
    <dbReference type="GeneID" id="87858465"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="244"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="577"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3348126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="834" mass="93617" checksum="9A585D5B0A286237" modified="2024-05-29" version="1">MTASMVSTPKPASKNNNTNSLALTQRSKFPTPQSLDKLTKPFKCPGSATRTVAVDRPARKRRKIDYKGAGGEDDEDGADKPYTNADRLALANRDANKFPVFAVKDKSQVFRKAFSVPLINKNTTAYNPNRPPPTLGLRQGAVFVAKPLHDPCDEFAIVLYDPTVDDKPKDVSPKAIEEKKKEETPEVKVDAPLVHKSLSEILGIKKKVEGEHPRVPVVIDPRLAKVLRPHQIEGVRFMYRCVTGMIDEKANGCIMADEMGLGKTLQCITLLWTLLKQSPDAGKSTIQKAIVACPSSLVRNWANELVKWLGADAITPFAIDGKASKEELTRQLRQWAIASGRSVTRPVIIVSYETLRLNVEELKGTPIGLMLCDEGHRLKNGDSQTFSALNSLNVSRRVILSGTPIQNDLSEYFALISFANPDLLGTRLEFRKRFEIPILRGRDADASEADRKRGDECLAELLAIVNKFIIRRTNDILSKYLPVKYEHVVFCNLAPFQLDLYNYFVASPDIQALLRGKGSQPLKAINILKKLCNHPDLLDLSADLPGCEHCWPDDYVPKEARGRDRDVKPWYSGKMQVLDRMLARIRADTNDKIVLISNYTQTLDLFERLCRNRQYGCLRLDGTMNVNKRQKLVDKFNDPEGDEFVFLLSSKAGGCGLNLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCFVYRFIATGTIEEKIFQRQSHKQSLSSCVVDSAEDVERHFSLDSLRELFTYRPGTKSDTHDTFKCKRCKPDGRQYIKAQAMLYGDTSTWNHFVNHYEGGEEKNGKGDPNGGSGGIKGIHDHLLRQEVGERDVSAVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT00</accession>
    <name>A0AAE0MT00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_146319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="157"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
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        </location>
    </feature>
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        <location>
            <begin position="86"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3347769.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="95" mass="10251" checksum="56902F18A8EE93BD" modified="2024-05-29" version="1">MRGELESLWQEQDAVAEWEAPDSQQEMRDAIKTETEPVLAGLETTGKWVTGPASTSRGTTEVTSTTQVGETSQVPVSVSYPVPTKSKLSPNSDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MTQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825442.1"/>
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    <dbReference type="GeneID" id="87862596"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="110"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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            <end position="201"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3350783.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="227" mass="23988" checksum="9435F2E1FA36E46B" modified="2024-05-29" version="1">MAPSSQCLCSLCGALVPTTCKGGSLNAGLVASTRVAVGPYVAVPGRAWLTWQSAPSISSSSPGQLSSGSSLVQFWCSSGAVWRRGDAASEVHRPQCPPTTHRHRRQSPSDAISYRGPVPSPWQAVQLCLCEKGSVCRLVPSANRKVPANSDHDGVDLTHHAPLPRAPIRAPTAKAFRSTPSFSRYPQVTQGYLTTGKNGTHPTAARPVGEILSSVPELDSTERSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MU17_9PEZI</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682820.1">
        <property type="nucleotide sequence ID" value="XM_062828765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU17"/>
    <dbReference type="GeneID" id="87865919"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="93" mass="10035" checksum="E5A3199E5C03CB44" modified="2024-05-29" version="1">MSVDSSGANTAVFPRTVVFDRAQGKAVPNDRLHPHIVLPATETLPASPGPGEPPRTQASHRDGTKWKILRLPDGRVTSSVHTLSRHRLSSIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUR6</accession>
    <name>A0AAE0MUR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_457239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684531.1">
        <property type="nucleotide sequence ID" value="XM_062826346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUR6"/>
    <dbReference type="GeneID" id="87863500"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041775210" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3351236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="285" mass="30696" checksum="F2BF6889F4A3AB4B" modified="2024-05-29" version="1">MFSFRRLLLAAALFLGAMLLFAQSAEAAKGPKITHKVYFDIEQGDKPLGRIVIGLYGKTVPKTAENFRALATGEKGFGYEGSTFHRVIKQFMIQGGDFTKGDGTGGKSIYGEKFADENFKLKHSKKGLLSMANAGKDTNGSQFFITTVITSWLDGKHVVFGEVLEGYDVVEKIENTKTGARDAPAEPVKIAKSGELEVPPEGLEGQSEWASPAYADEDEKLAAPVPVSDSKPPAHDSIPAATADDDDTGAPLFAKVLFFGVLVLGLVLYIRLRRAPKGTYGKGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV87</accession>
    <name>A0AAE0MV87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trm61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 13">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_459008</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685071.1">
        <property type="nucleotide sequence ID" value="XM_062826436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV87"/>
    <dbReference type="GeneID" id="87863590"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000189">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="15">
        <location>
            <begin position="132"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="15">
        <location>
            <begin position="300"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3351776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="508" mass="57083" checksum="C3F28B424264806A" modified="2024-05-29" version="1">MTDAAMTRPTVSPFLEPGLRTKPSSLAILQLSRDNLLPIYLQEPSGEHDGYAEGAVVNTRYGSFPHSTMLNVPWGSQIRASKVDTGSRGRKRKRGPRDDASRDDAEENQPETTDNNATEAIGVKQAVADDSGFIHVLPPTPELWTQSLPHRTQVVYTPDYSYILHRIRARPGSTIIEAGAGSGSFTHASVRAVYNGYPSSAEDRKGKVFSFEYHEERYHKMKKELTDHNLDGLVHLTHRDVYNGGFLIDGKSPEADAIFLDLPKPWEALPHLSRRKPQNQAKEGEDSAAEWTSPLNPKRAVHICTFSPCIEQVTRTVSAMRRLGWVDIDMVEIANRKLHTIRDRVGLHYQTDRGVNVSPHDVEEALERLAEIEERVREQAARPRDDGAEDADTAMKNGDEAAKKDDDKTSAEQPPFQTPWVDGRLITKGEPEIKTHTSYLVFAVLPREWTEEDEAAAFAKYPCGKEKAVVGSIDKQTRKKERREQLQKIGDRKARRKERAEKIAEAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVZ7</accession>
    <name>A0AAE0MVZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_544273</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686372.1">
        <property type="nucleotide sequence ID" value="XM_062829279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87866433"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="231"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="432"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="575"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="712"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1076"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1325"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="868"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1269"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1449"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1280"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1455"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1469"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3354994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1492" mass="164569" checksum="CD8393FF0B2C4689" modified="2024-05-29" version="1">MATQQSAHELKQQGAIEAAQDPNSSVTAENAEKKIVADSQQLGITAFTFDPNASAAEKAAQAREAIPDGLRRPKGLAIVSDLDDGTKADVDLPPPSKAGALDLPTTADGKVIEDDRTPEQIEADLIKKVGWAPRFGWPKDPEEEQDLLDHATWVESNLSENYFGEWYHNVAVIVFACLSSWLVAVLGGGLGWVFIIMACCSTYYRTSIRRVRRNFRDDITRELGLKKLETDNESVEWINSFLVKFWPIYQPVLAQTVVNSVDQVLSMSTPAFLDSLKLKTFTLGSKSPRMEHVKTYPKAEDEVVIMDWMFSFTPNDTADMTARQLQNKINPKIVLEIRVGKAMISKGLDVIVEDMSFSGLMRLKIKFQMAFPHIEKVEMCFLERPKIDYVCKPLGGETFGFDINFIPGLESFIQEMIHATLAPMMYAPNVFPIEVAKMLAGTPVDRAIGVVAITLHGAQGLKNPDKFSGTPDPYAVLSLSKRQPLAQTKVIKENDNPRWNETHYIIISSFNDSLDIDVFDFNDFRKDKKLGVASFPLENLEELNEFENERLELKYDGKARGAVSCDIRFFPVLEETKLPDGTVEPPPESNTGILSFTVEQAKELDASKSMVGQLNPYAMLLLNGKEVHKTKTMKRTNQPVWPNGSKEILITNRKHAKLGVALKDDRDIAGDQLLGTYQIKLDDMLELMAKGQDWYNLAGAKTGRVKMMAQWKPVAISGAAGSTGGYTTPAGVLRLHFINGRSLRNVEALGKSDPYVRVLLSGIECGRTVTHKNNLDPDFDEVLYIPVHSPKERLQLDVMDAENMGRDRSLGLTEIFAGDYMHKDPETGEWLVHEKKDLHQDGLRMHGKGVAKGVLSYTVAFYPCLNVADPEDDEKDEQSDQSSEPKQSLDVPRSSDAGKFSSTLERTDSIKPENGGASRPITPKTPVTPTSIAPSRKSRDEKEPPKLRLNPQELLQYESGLIIFKLMEAELPKSQCRVEVCVDDYAFPSYVSSTSRTKTHTFDEIGDCFIRELEFSKLTIKINERSEKQEDNGKENTLARLSGNTLDTLKQCLNNPTTLKLKNEDGKVYSIKVSLKYVPVRMQLDPSESINNMGHLRVDVLDAQNLPSADSNGKSDPYVKFEFNGQEVFKSKTVKKTLNPTWNEFFEVPVPSRIAATFKATVWDWDFADKPDFLGAADINLGQLEPFRAQEVRLTLDGKSGVLRLRLLFRPDYVTRTRQGTSTLVGTFAVPGKLVTGVAGVPRKGGAAVVGAVGHGVGKGASFIKRGFRSNTKRDDDSDSTNSSVELPTIVTNAPEAASGLKRSEAITEADGSSANELHHARTMSVGASSVRSAMFPGASSGTASFTVVSASGYPPSTDVYVMITQMKDGKSKAVGKTKHRKSSSGTVKFDETFNIQCTPDSQFKIEAKEHHTFGSDDHLGESVYFVDESNSGQEKALKVGSGTVYLKSGFAPSESAQDPSSALSPDQSPKSSSLRRSFLSKGARSPSRDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW18</accession>
    <name>A0AAE0MW18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_16072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685896.1">
        <property type="nucleotide sequence ID" value="XM_062821230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW18"/>
    <dbReference type="GeneID" id="87858384"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="80" mass="9395" checksum="4EA97298F633D520" modified="2024-05-29" version="1">MFPPPVRRLFKRRCVDGCRRSTYPERQSVSFPKRNEVLIKWLAVDIKHKGSIICISMEGLVHFRMLLTPTSIAVLLHYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWG2</accession>
    <name>A0AAE0MWG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_459876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685370.1">
        <property type="nucleotide sequence ID" value="XM_062826490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWG2"/>
    <dbReference type="GeneID" id="87863644"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="271" mass="30836" checksum="E0777203E065C24C" modified="2024-05-29" version="1">MCYVLYQNEYTFVCGHSMRHLKSARQRSACLYNNCSAVEFQTSVHGTPFSYPCQRCITEGRYVANPAAAPEYRTGWIPQIGAQQGQDQVQRPALEREDVPVQQAVPVPVQHQQAPAPVPVQHQPAPASVPAPAEQVVSVKDEAEEEVEGEPKRDLKEDIRDDVRVILEEEIKALMGEEVHQNIIEEIKEKVKGNVMKKLREVLVREAEKIWNKAGEILEEDVAKVVEKVKEEVKEEDVMEVVEKVEEEAEEEVKKEVEEEEEEVKVKVESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWN2</accession>
    <name>A0AAE0MWN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_515351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686389.1">
        <property type="nucleotide sequence ID" value="XM_062828655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWN2"/>
    <dbReference type="GeneID" id="87865809"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="241" mass="26765" checksum="AFBB041C2F28888D" modified="2024-05-29" version="1">MSLTFRRGLTTMASLKKATKVVCIGRNYADHIAELNSAKPKQPFFFLKPPSSIILPGEGPVIRPRGVDMHYEVELALILGKRVRDHDASDLKGALDAIESYALSIDMTARNVQNEAKKKGLPWDIAKGFDTFLPMSKLIEKSRIQDPHNIELYLKVNDEVRQNDSTNLMLFQIPRILSDISKVMTLEAGDIVLTGTPKGVGPVVPGDVMRAGIRVDGKELEEAKIEIAVEESTRSYEYAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWR4</accession>
    <name>A0AAE0MWR4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_36697</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686494.1">
        <property type="nucleotide sequence ID" value="XM_062823683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860837"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000408">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000428">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000055">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000305">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08509">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00789">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="718"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="1521"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1861"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="301"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1197"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1814"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2088"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2245"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1222"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="2259"/>
            <end position="2269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3355116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2269" mass="251170" checksum="697B75FD7335377E" modified="2024-05-29" version="1">MTRNEGGSRFGSMTGSSTDSARSSITAKPFPLTPTSSSTTRPPSPPPQAGSSSSSQNDQNVSRSASQGSRRPAPTRLMTDDGTQFASRSSRDFESPHSQARSHSVSQATLQSYQSQQTPTQQQPQQQVSPTGGSGGSRLTQSPTTPSNASIREHRMSELGGYRREMAAMLDTTGGGSRTSSSHSQQQQQQQQQQQQQGGAFSNLGQYAPYLGGNNGGGMSMGSFFNDSTDNLSVISQLSPGVRPMTARPSQASTGSMEFPDSAYYDDERRPSIASITTTASSQGSRTSKTRGGLQKLQQFFGDRDDWPGRDSSEISLPQPSHSGPMSTGKEHRSHSYSLGSGRSHRDRNYSNATDHQFGSVSTAGGRDRDASPVPSRPRTPVPAPEVVPFLYQEADDIARYGEAPVRTSLTGPDRDRYIDSSQNPPKTSSSARSGHSIVHLPGHHKHNKSNEDPRTLRPTLSREDSAATFARDHRNGSSSMMGTRSRAQSPAPSWTGPSRGLKGTSISDGTSSPAPSHKKGLLGRFRRHNKDKEDGSSLRSGSSHTLVHRPSRQDLSRAAESTYPASVNGSDPSEQREVPVPVRPGFVRQTTAPGFTTKLFTSKKTSSVKQPQDDMDEEIGPTDTHMGGGTVYHLDTNLNDMEGILTKPQPMTPLDNSFSTRRESEKMIVPITTEPEGAWAAPDSWAVRDNKKSLAPQAVENEDLSSRQPTEEKEKKSNYYIRVFRSDSTWTTLTLPLTATAEDVIMGVARKTYLPPGAQDSYSLLIKKHDLFRVLNSAEQPLRIQKRLFQQIGYQEKDGIDEIGREDNSYICRWVFLKEKEADMHLLSQDINFRNQKLNHVDLSGRNLITIPVPLYRKAAEIVSLNLSRNLSLDVPRDFIQACTSLRDIKYNNNEAQALPKSFATASKLTYLDVSNNRLQDLDHSELSKLTGLLKLNLANNCLRSIPPTLGAYKSLRTLNISSNFLDVFPSFICELETIVDLDLSFNSINNLPGNLEKLRNLEKFVITNNRLSGPISESVRDLVSLRELDIRYNQISTIDVLSDLPRLEILSADHNQISKFSGSFERLRSLKLNSNPIVKFEVKAPVPTLKILNLSNAQLASIDESIDNLMNLERLILDSNYFVSLPNQIGNLKRLDHLSMANNHLGELPPEIGCLTELRTLDVHGNNIRKLPNEIWWANKLEHLNASSNILTEFPKPASRAPQAPGEASPSPGAYPFPNGNKNGLLSRTPSTDDLNGDASRRPSQASSTLLGVAVSPVPSGPDNRKSSMVSLYGKGGRKTSVVSRTTTQSSTGVITPINGPRKDSSLSYRFTHTFSGSLKNLYLADNQLDDDVFEELKHLPELRVLNLSINDLSDMPQGTIRSWPQLVELYLSGNELTSLPAEDFLEEHCLLQTLHINGNKFINLPAEISRARKLQVLDCSSNNLKYNVTNVPYDWNWNFNRDLRYLNLSGNKRLEIKNNYRQPQSYRDDDFADTDFSKLMNLRVLGLMEVTHTLPNIPDQTEDRRVRTSEMKAGAYLPYGMADTLGKNEHLSLFDLVVPRLGSVETDTLVALFDGKELSTGGSKIAKFLYEEFSRLFILELEKVKGKPNETPVDALRRTFLSVNKLLMSLSNSADERGLDSHPGRNYAHTVLTKEDLNSGCVATVAYLSELKLYVANVGDVQGMLIQANGSFKMLTKKHDPADPVERSRIRNAGGWVSRNGRLNDALNVSRAFGYTELLPAVQAAPDITEHTIDDKDETVLIASKELWEYLRPELIVDVARECRSDLMQASQKLRDLAIAYGSTNKLLIMMIGVANLKQRQAQRFKGQFNSAFSMPQDDPSHAPPSGNKRRKVRAEGPLDSNLIRLDAEVKPPTGQLSIVFTDIKNSTQLWENHPEAMRLAIKLHNDVMRRQLRMIGGFEVKTEGDAFMVSFPTATSALLWCFAVQMKLLTVDWPPEVLSNSSCQPTYDRNNNLITRGLSVRMGAHWGEPLAEPDPVTRRMDYYGPMVNKASRISAVADGGQITVSSDFITEIHRCLETYKEPVDVDEDYFEDDPTARAIRAELRALSSQGFEVKDMGEKKLKGLENPELVYSVYPHALVGRTEQHLAHAESTQDPAAVQPPGALAAPKPATMHPDSEIQFEPETIWGLWRVALRLEMLCSTLEEPNARGLQAPETELLERMKQRAGEVTDHFLLNFMEHQISRIETCITSLAVRHIAIGSGPITKLNDLRAPMNDVLSTLKGQMDELARYKAMYGSLDQADTDGATDNTSNGDVDTLDGSDTEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWS9</accession>
    <name>A0AAE0MWS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_38265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686539.1">
        <property type="nucleotide sequence ID" value="XM_062823704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWS9"/>
    <dbReference type="GeneID" id="87860858"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041902590" evidence="10">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3355161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="203" mass="23387" checksum="10A1371DC9F661E5" modified="2024-05-29" version="1">MHFLTAAKLLLSASLFGAAAAHNIVLPAHGRECFHENLHRDDKMTVTFQVGDREFGSAGNLDIDFWITNPLNQYETFEKSISNGDFSFEAKHDGKYVYCFGNEHWGANTKEVSFNVHGIVYVSEADAPQDPLEVEVRKLSEMLEMVKDEQSYIVVRERTHRNTAESTNARVKWWNLFIVGVVVGESLFQVWWLRRFFEVKRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXC4</accession>
    <name>A0AAE0MXC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_453140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687186.1">
        <property type="nucleotide sequence ID" value="XM_062826135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXC4"/>
    <dbReference type="GeneID" id="87863289"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="158" mass="17930" checksum="FC86C84C80366CB0" modified="2024-05-29" version="1">MSDNTLLTLPSSNSVKQFVLFFCEGTDASCGSWGPLCDFCPYDGIDGIFQLTDKKQRTRKHHCMQHNTNKLLQHNVFVFARMRPSALGCSSHPFLPIAITIAFRMLPRIFLFICNNRGRATNATWLLTWMVSFLLKMMVDGVCTLMAGCVALRFLRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J040</accession>
    <name>A0AAE0J040_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_565714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676647.1">
        <property type="nucleotide sequence ID" value="XM_062830293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J040"/>
    <dbReference type="GeneID" id="87867447"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="291" mass="34188" checksum="3B003309D277607F" modified="2024-05-29" version="1">MEGTLEHTPEPPSELPPEPPPHSHGPLRSSITWPTGIWWDNKRAISPLWRELPIELVQKILNHLIESFINRCFFNDECEFDADGKLVLSPSIGIANGMSFKTWNLRRESLFRRQRPLIERHFRDEWLSRVTLYLCLDAEIEAPSLRYFHFPESEDHHAMVRAGPSQDSQRDSGTKVTFFLYKPEENGFVVDEGLMTLKELMDDLLDAWDDYVEDRTSSCLVVGVRARTWQKDVIEFNRAMDMYNLRKGSVDLEGLEVSEDGRYIRFRWEDFITAMVNWFLYETEEERSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0K8</accession>
    <name>A0AAE0J0K8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhamnogalacturonan acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_481262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676815.1">
        <property type="nucleotide sequence ID" value="XM_062827625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0K8"/>
    <dbReference type="GeneID" id="87864779"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000010">
        <property type="entry name" value="Putative rhamnogalacturonan acetylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042247112" evidence="3">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="268" mass="27968" checksum="6A9AC98EC2579FB0" modified="2024-05-29" version="1">MRFSSTTLIAGLAAVSVDARSVNPIEKRATPTVYLAGDSTTAKTGGLLMGWGEYLPQLLTIPVVNKAVPGRSARSYTNEGRFTELAKVVTAGDIVVIEFGHNDGGSPNSASDNGRSDCPGTGSEVCVSGKTGEKVYTFNHYVETAAKSIIAKGASVIFSSQTPNNLWEGGSYGGYGAPVRFVGYASLAAKNLAGTGKASFVDHYQAVANMYLKLGSTKTNSLYPSDHTHTSPEGADLVAKAFAQAVKLAWNGTTPLKGYLKAGNPTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0L2</accession>
    <name>A0AAE0J0L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Centromere protein H (CENP-H)-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_330605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676914.1">
        <property type="nucleotide sequence ID" value="XM_062823507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0L2"/>
    <dbReference type="GeneID" id="87860661"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="8">
        <location>
            <begin position="118"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3334748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="248" mass="27552" checksum="20B9850C04D17A09" modified="2024-05-29" version="1">MSALVPDPNPRLSETEEEALSLYDRLQELHIQIGLLQAQQDHSDPQRHSEVDEARTQLLEAKAALELRDYVFESAVVVRPILRAVHGGTQASPVERSVFTVVRICNLFFSDIADVCFVSRDILPLIRQRDLVSAKAAQQASASHQVRDRILDLELERLRIGQQNATLASELLRLSKTTGTHDVQVDGATKLERQLGNTKGELQVSRQRWKTIKGATSALVAGSGVDWVRDERLRGLVLDPPDLSTKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0N7</accession>
    <name>A0AAE0J0N7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_330940</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676917.1">
        <property type="nucleotide sequence ID" value="XM_062823508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0N7"/>
    <dbReference type="GeneID" id="87860662"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="297"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3334751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="554" mass="59905" checksum="68226F49812C0402" modified="2024-05-29" version="1">MEVQTVEFKPFTDQKPGTSGLRKKVTVFQQPHYSEAFITSILLSIPEGAEGAFLVIGGDGRFWNPEVIQLIAKIGAAYGVKKLLIGQDGILSTPAASHVIRKRKATGGILLTASHNPGGPKNDFGIKYNLANGGPAPESVTNKIYEVSKTLSSYKIASIPNIDISTIGTKTYGDLEVEVVDSTADYVEMLKDIFDFDLIKKFFATHPDFKVLFDGLSGVTGPYGKAIFQQELGLGAESTQNCEPSPDFNGGHPDPNLTYAHSLVEVVEKNNIPFGAASDGDGDRNMIYGAGAFVSPGDSLAIIAHHAQLIPYFKKNGVYGLARSMPTSGAVDLVAKKQGLNCYEVPTGWKFFCALFDANKLSICGEESFGTGSNHIREKDGLWAIVAWLNIIAGLGVANPGVAPSIKQIQKDFWAEYGRTFFTRYDYEDVDSEGANKVVGILRDLVEDPNFVGSKVGDRTVTEAGDFSYTDLDGSVSSNQGLYARFSSGSRIIVRLSGTGSSGATIRLYIEQHSTDPATYDMDAQDFLAPEIKMATELLKFKEFVGRDEPDVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0P1</accession>
    <name>A0AAE0J0P1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_331467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676934.1">
        <property type="nucleotide sequence ID" value="XM_062823512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0P1"/>
    <dbReference type="GeneID" id="87860666"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="512" mass="58504" checksum="52E826FF19DCCDDC" modified="2024-05-29" version="1">MDPLHITEFGSERYLDKVTSATQPPSTAAPPSQFLLPLRGAHPPEAEDAAIRASEPKRLEKKGFLSFRKFHAKAPSSSNSLDQGERRFSATEPLPRQSTSFDRQFHFLPTELQIEIIASLPLSDVLNLRLTSRSLHALISLNEAPIARHHLDNHLPAYAKRLYPPPSPSALNLHYLCGIWHRLHVAAKLSYLMCEWISRELFLRNTEEKKKAFAPQRERMRRRLIPLLFTIFHFFETYRDLHLKYLAENDGKGLLKEPYTINPIEAQIMSLYDDRTLLRVHEVFPLVISSFCRRLRPPSYVGRVERSIRGYLRDKPPDEVHVAILCIGGLRDVERIWEVKGYNTRRTAVDNWYNSITRDTAEQETKKRRGMLGLKRKKSSFSMGKNSLGDAVAASARISGDAGMTTRDPMSNLVFNTSLSTGRPMGPLARDQLKLLLSDLPILQKIFLETAEALILERKIVERASDIKRNAQIFTDLICEDGFEEEDQWLYGTVAPESVRPNLEAIEEDVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1Q5</accession>
    <name>A0AAE0J1Q5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LrgB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_76528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676732.1">
        <property type="nucleotide sequence ID" value="XM_062831381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1Q5"/>
    <dbReference type="GeneID" id="87868535"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3334566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="69300" checksum="B28A10B6B13520BA" modified="2024-05-29" version="1">MAPTLSSLPTSAPPTEAMCLPLSTATRQRYARLRHHLNKQTQPWDGVVATLLVIVAQLLIAGIDFMLDNHSVDFPPSILAMVALFVVLSACGCVIPRLEEFYQKHLSRATNLLNRHMSIGFTIPFVMICRGPLADARTVGLVIACFVLTGILNTISTYILALPIHSLMVRWKERSPTYESENTEVIEGRKERWSWISSKIIFERDSMASSFSFGVSCSGDESACEGTRPPTSLEKVQPTEAQQDTPKTGFRGWLSRNPMLVLCWFLTFTVGIPLRYAVHHDASLATFLLFATWFTMLEIQAAVKRAEGLAPWIRITLTGSLNAVLWTSFVMMAYIYLDAAISDRALGKMLDSLQTKTTLSHLLLHSVNGGVDAEGNKLNVSMAAGDIAQSILNAGLVAWGLKLYEYRRQLLSRAGLTVLIVSSILALGNVALGPLLTRAIGLAPASRNIAYTARSVTIAMGAPVMVMMGGDASLNATMVVISGIIFQMGLGFGFGSWLERTIFSRFVKQQEQPTDNTTAERTEDKPEGAKTEPKASQTELLTVPVRQSFDLEAQQAARTAPTTATPAQGQGMNDPHTVAAGLTIGINSAAMGTAYLYEVGSEAAPYSALSMMALGVMTVGFASIKPLAEWVVAGVGGQMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6Z8</accession>
    <name>A0AAE0J6Z8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_477633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
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        </location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3338062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="106" mass="11557" checksum="ED1D9F6D1C86E250" modified="2024-05-29" version="1">MKLISVLTALTAFKAATALPSGSMSMTDSAPHPTFSVSLYTLTNYTGNTKTITSKQGACIKVDDSLAYQVSSIKINQGVCNFYLLRRQSSVWLQALQARGSWYRLA</sequence>
</entry>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677529.1">
        <property type="nucleotide sequence ID" value="XM_062823318.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87860472"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J8R0_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062829813.1"/>
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    <dbReference type="GeneID" id="87866967"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="163" mass="17535" checksum="62E346BEE423D38A" modified="2024-05-29" version="1">MSSFTLALVISYDSPGAWVCLAMRSTISPAALMGKPKGKANTAVLSGNMIDNQADPTPYTTVDSPDLSLLQRLAHPTLPPHAGYHNLDKVHDVVGEIPNQPAQLMHALHALHTGLDGAEEEIKRLNARIERFTAATAEAAEAMTAMVEDESDSDEELLAFLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="6 7">
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678974.1">
        <property type="nucleotide sequence ID" value="XM_062828381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9M0"/>
    <dbReference type="GeneID" id="87865535"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3340032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="62081" checksum="F4C00B0C8C48AB21" modified="2024-05-29" version="1">MTIDTSEVAAQRITGFPYAFVPHLPLKADRHTHLEPQTAMPLIVDTDSESDFTTNPESRFGVNKTVAVIGSGISGVCAAAHLLKHGLSVTVFERSNGAGGVWKFDERPPEDPPYVYRPPSYGDQHHIPSGAVFDGGDADFSNLEIRFAPPSPCYVGLKTNVPTPLMGTALGNWPEGSPASVSHSTALQYIRSLAKRSGLDAVTEFHTRVEDVRKTSDGSKWRITTLALEKEDGIPSARFTQKVRDFDLVVVASGHYNMPRIPQIEGLKEWKDSFPDRVIHSKRYRNPEKYRDQNALVIGAGVSATDVCKELGEISNKTYQSTRNGRFDLPASVLPPNAVRVATVERFVPPEAKIEGEEPTLGNNQPIPGSVVLTDGTVLQDIHQVVIATGYIVSYPFLPQLHSDTTVDADPNDELVVTSDGVMTHNLHKDIFYINDPTLAFIGVPYHVATFSLFDFQAQALARVFAGRAKLPTQEDMRRKYEERVESKGRGRFFHSLVTPGHEIAYVKDLAEWVNSYVKETEGEPMPTHSEEFLKEYEVLKSRLRGLYPEVAKNDGRLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9M4</accession>
    <name>A0AAE0J9M4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_476756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678895.1">
        <property type="nucleotide sequence ID" value="XM_062827390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9M4"/>
    <dbReference type="GeneID" id="87864544"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="239"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="720"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="779"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="581"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="814"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="835"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3339535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="888" mass="97411" checksum="EACEA982AD32EF1A" modified="2024-05-29" version="1">MSSKPKPKRPNAVRRIMEREESRERRFREVSVASNGGASNTTPAPTAAPPKPNRPKCANPKCPKPNVVDGTCQTCGMVADDSNIVSEITFGESSSGAAVVHGTHVAFDQGGIRGVGGLAFRRVAGGGASEARERSLREVKALMQQYSYQLRIGQSISDIAFRYYKACSHANFVQGRRKQNVAAICLYAACRAENNHKIMLIDLADLLRADVFALGRGYKDFLNRFPEFLTGPRPIVIEDLIFRFASKLEFLHDTNKVALSAVRIAKRMQHDNITHGRRPAGICGAALIMAARAHNYRRTVREVVYIVKVTMATIQERMDEFASVPAAQMTVQDFHDKDPLEAGPAHDPPFVYKQTDEWKAKHTRPKKRKRKDAGDGKKRGAKKTRTNDGSSAAPQTIDKDGFVVPPVPRKEGDSDPDVEAEALIVTAVAGEEQQLKTLVEEYGELDEEDEDEDDDDSDSDSDSDDEEDEVDPSSEVAFAKAQGVDIAASGASTSNGETAEKKSDKKKKKGGKKLRKITMPITQEWQTDEALLEKEMEGHLHDPEFLNAAQAEKVATDKRVETEKKKKLADARKKKLELAQKAKQQAANSASASSAPAPASAPASTSGPTANSTPAPTSTEQPNTTKETDTVMEDAGAREERQDEPVTDRLNPSFPIQYTRPQYVPNKALDDPIVHEHEFADDPEVKYCRLGEAEAKMKEQIWVNIHVDFLRSKQQKVFDAKLAEKNKGPNSNKRKNKKNRVEDNGGVPETAEEAAVNMMRNRGISTKLDYSKLGQIFDLDFNEKGPGSNEADSALASESGDATEDHSNEGESSGGAAAAAADTTTAAGGKTHEDAVEEEAEEEVEEAPEEAYEEYNENEGGYDEYDEGGEEDINPFADDDEVDDDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9W3</accession>
    <name>A0AAE0J9W3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_297743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678706.1">
        <property type="nucleotide sequence ID" value="XM_062823109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9W3"/>
    <dbReference type="GeneID" id="87860263"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="81" mass="8498" checksum="53FC2A79320EE529" modified="2024-05-29" version="1">MFPSPASRIALSTGGVPSGTSSSNPRLFVRHPRLAFFTFALAGVGATFKYVSTTIRNNEVAQKSSPGSQFYVSVDRSGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA25</accession>
    <name>A0AAE0JA25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_471580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679134.1">
        <property type="nucleotide sequence ID" value="XM_062827110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA25"/>
    <dbReference type="GeneID" id="87864264"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="291" mass="33086" checksum="DEB08B4D33549705" modified="2024-05-29" version="1">MVYRAILTITCTINTSSKEHLHDQQPNQASEQLDQITSLKNLALSCRQVRDELVHEYVAYVLPFTQIHLGSAYRTPTPSPLALTNHRIFQELQSSSFLTQNIQHISLHWGGCTCSEDGSRFQKQIEPRACLFWLTALPQLKTLEIVFTDPFYLPIQRFTSASMTGLPGPGPGVAEEAVEEADAEWSDSDDGGAHELVEFFCSFCWCEGLMALPPTLEKVIFRVWCREDPDDEVHPAAVDETWEVTKWYRRTRVAEEQYERTGIWKRVKEDHEDGDESEVCSCPALPTLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAH5</accession>
    <name>A0AAE0JAH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Abscisic acid G-protein coupled receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_472110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679305.1">
        <property type="nucleotide sequence ID" value="XM_062827132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAH5"/>
    <dbReference type="GeneID" id="87864286"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
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        <source>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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            <begin position="24"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3342276.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JBT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_578012</name>
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    <organism evidence="8 9">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679357.1">
        <property type="nucleotide sequence ID" value="XM_062830714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBT8"/>
    <dbReference type="GeneID" id="87867868"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="322" mass="35917" checksum="545A48521E0148FB" modified="2024-05-29" version="1">MENVLIGKDAILNLRMGITFPDDQAPEVQPEPVENGQSLTDQVIAATGPKAHPRLAQIMPSLVRHLHEFAREVNLTVPEWMAAVDMLNECGQISNDRRNETQLLCDILGLESLVDEITSNLLASSNAGTPSAVLGPFYRHNAPLLPNGSSIVKNLTPKTPWYSQAIADSAYITGRVLSTDGKPIHGAIVDIWLAAPNGLYEQQDDSQTDMNLRGRFETDQDGRFAFYALRPTSYPIPFDGPAGRFLTLLDRDPNRPGHIHFIVSAPQHRALTTQIFDDRDKYLTEDAVFAVKDELVVKFLPRKGDPKARWYLEYDFVLGREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBV7</accession>
    <name>A0AAE0JBV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_272297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679766.1">
        <property type="nucleotide sequence ID" value="XM_062822756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBV7"/>
    <dbReference type="GeneID" id="87859910"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="451" mass="50067" checksum="C04ABD2A94BC3ADD" modified="2024-05-29" version="1">MPSNAPVEGSNASDSNQKPKPHVLIIGAGISGLLLAQSLQLHSIPFTIFDREPSPTARDKKENLGWGLTIHWSLSALRSLLPEELVRRLPETYVDRKAVEDGRTGTFPFHDLSTGELKASVPEVGENSRVRVERRRLRELLGVGVEVKWDKSVTQVDNREDSVTVTFDDGTSTSGSLLVACDGANSVIRRALFPEEQYPRYRIPVRVMGVRLDCSKEDIEPVRTLDPFFLQGSCPATRLYVYISVLDAPGNNPDKRTDKYTVQVVVSWPIRSGVLGQSSPVPVPDTNDEKLGLLKTFAESWSEPFKSLVCNAPGDTEVKRLDLSDWAPPKGLRSTGRVTLVGDALHPMAMYRGEGANHAIFDVLEFAQQVLPHLEDTTAELRNAIDRYEDLVVARARPAVFASRQACIDAHWWERISRNSPLLSRRTPNVEFEEEDVCIWSDGVATAKSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCH2</accession>
    <name>A0AAE0JCH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_526053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680066.1">
        <property type="nucleotide sequence ID" value="XM_062828851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCH2"/>
    <dbReference type="GeneID" id="87866005"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000071">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF4">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="456" mass="48902" checksum="71329D8D707125E4" modified="2024-05-29" version="1">MATDSSTQTETLPEIDEDDFVIITHQEANALRRPRFLNDISDYIDSIAEELWPINKKIHDKPELGYGEVIAHYTLTAYMKTQPGWTVTRSAYGMKTAWVAVYDTGRRGPCVSFNVEMDALPAIGHACGHNLIATASLAGALATAHLLSLYSLPGRVVLFGTPAEEGGGGKIRLLAAGAYKDHGVDISLISHPGTVGDCALTHTTAYIRMKVEYFGREAHAAAEPWLGVNALDALITAYNGISVLRQQTMPSDIIQGHITDGGAKPNIIHAYAAGIFVVRAATQRRLEELLGKVMACFDAGAMATGAKVKVTRLMAYKDHVPNRLLGRSYVRYFNPLVPEEGDGGRDGDGNEAGGPKKIPEDQDVDKMRGWSGASSDQGDIAHAMPSIMPGFEIPPGPGGAGPHNPGFAESAGTRLSFERSLRVAKALAGTAVDVLTVDGLLEEIKKEWRRSMNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCM6</accession>
    <name>A0AAE0JCM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_429262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680379.1">
        <property type="nucleotide sequence ID" value="XM_062824812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCM6"/>
    <dbReference type="GeneID" id="87861966"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="708" mass="78711" checksum="55E46E81DD417F95" modified="2024-05-29" version="1">MANYFELNHLPQGQVEYDERLQFVPVSETTSYKGASIGDVSQKGLDNSTTPVAYEEVAPEWPQGPQKIAPKGYIWWIGTIGDFILSLTPVAFFVIAALAIQLEGQPTEHNEHGESLVEATKLAPTIYPIVFAAVASRFYKILALWSATRSRGITIGALEQILGSQSFAGSLFRLFSVRSHISLGIMILLTWALSPLGGQSSSRLIFKTIQVSDSKALVYYSTTDSESSFSSASGLQVASTAANSLFTSSLMAAEEQRRSMTDLWTRPRIPRLRDLSNNDWQIVDQAAMTEMDYASLIGIKILGLGNFNSTTSYNLTAEATYNDLDCKQVQTGASVNETLAYIPEDRWTTPIYYVDKMNDTTGKLLPGYTDPRSPDNKRASFFVTSDFSTPERESGGHLHIMFGSHEGDLNYTLYNCTLRNVPLELDILCSSPLGCGAQRIRRSKSPQWDKGDAHSPFTLEIPVVYNFLSNFPFAAGFFDNGSPRYQSTIDNYLRGITQFPFKLNFLSPWPTNVTDEAFSRRLTLLFNTYYYASLDPFTATDSNYSKFPGNTDRIMSQPVYSGPYLSNNYEGATIVMVNNATEYTHREIYGLNRHWATILVLCTSILQILSLAGLFLRLTTPAPDIFDYGASLTRENPFVPVPKGGSAIGGPERARMLRKMRVKMADVRPDDQVGYVALVATTGVVDQGVNANGEVIPTRALSRWRRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCZ6</accession>
    <name>A0AAE0JCZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc-finger of the MIZ type in Nse subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_550087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680695.1">
        <property type="nucleotide sequence ID" value="XM_062829708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCZ6"/>
    <dbReference type="GeneID" id="87866862"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="279"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3342902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="403" mass="45160" checksum="98891C0902AA66EF" modified="2024-05-29" version="1">MPPGRLVQGSRRPQSTASASTSAHNGSDLPPYEPPSHPMNDAGRQALANITNNNAEMRKYEDHLSKSATYLREAVGAINDTLFARKSQLTSKIEKRRGRGESEKGEDEAELEEYVNKLNGDVTHLTDEIEAALRQVIDYRAEVQGEKLVLGSVVDQVQSQKPRRERPSRKRKAAQRVSDNSDEEMGGVDDEPEEAEAVEAEDETPLTGVREALHKARESKARQYRATSAYDRYASNNEYIAFKKMWHDAQHPEDQVPLPDATTWFDNQGRPIRDGAPAGDEDLIIEREVQDLTCKLTLRPFEEPYANQKCPHVFEKTAIVEYLRGTGGKAQCPVCTKELRIKDLYLDELTLRKVKRAARAARESEDSSNAGPEEQVDESLLVGESTQLRSGRASNEIKQDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDF9</accession>
    <name>A0AAE0JDF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_443762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680783.1">
        <property type="nucleotide sequence ID" value="XM_062825646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDF9"/>
    <dbReference type="GeneID" id="87862800"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042061164" evidence="2">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="174" mass="17280" checksum="5F7A1D47A473E62F" modified="2024-05-29" version="1">MKAALLPLAAMFAVAAAQTTSVCGAAYIVETCLGTENSRLALCGRDDYGCKCAQYPNIIACYNNCPNDPRKASDMGQRDTWCALDKQYPSSTSKVAVATTNVNTAPAAAATTAASSSGSDNENTDDANTTATDAASSNTASAPSSSATGNAAGEVLVNAGGLLAAVAGVVAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDT8</accession>
    <name>A0AAE0JDT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_443782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680806.1">
        <property type="nucleotide sequence ID" value="XM_062825647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDT8"/>
    <dbReference type="GeneID" id="87862801"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3343013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="162" mass="18448" checksum="821ABB03E373BF20" modified="2024-05-29" version="1">MPLRSPTIAVLVWAETWMGLRSEAQELQQSLTALTALGRRRRIRHVLGSPSSDEKLLHAIGQWVPAWKAHRKVPSATGSSSRRRGRLAVNVEHHHHRHAESPGFMLVNSVRRAILKQVRLRNGPRVAHGGWPIKFREQHFEQLHVGECQTFEDELGDYPDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE10</accession>
    <name>A0AAE0JE10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_181508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681252.1">
        <property type="nucleotide sequence ID" value="XM_062821513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE10"/>
    <dbReference type="GeneID" id="87858667"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="197"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3344639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="322" mass="35226" checksum="F649B5E7C201B9D1" modified="2024-05-29" version="1">MAGSRINFTNYLRNLNAQEPQVEEFVTPNDEDLALFTNTNFFDYETGQNTDYQAPPVKPDAVVAPTPVESAAASPDVQTDAFMTDFLSGLDQGLEFAAPAADFNFGDFTTTYASPTIPAYPDALGPIQPNPQAAYPPVSQHYAPHHVQHPHQPGYVLANPPQLGGNKRKASDAMSVPPTPGARVMSFEDASRLAAEEDKRKRNTAASARFRIKKKQREQALEKSTKEMTEKVTQLEGRIQALETENKWLKGLVTEKHGSKEDILKLLREFSAQAAKVSKDAAAAAADKAEAERAKEESSICVSTSSPSSDESVDTNKKRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE18</accession>
    <name>A0AAE0JE18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B0H65DRAFT_590180</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681083.1">
        <property type="nucleotide sequence ID" value="XM_062831065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE18"/>
    <dbReference type="GeneID" id="87868219"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="998"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1031"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1095"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAK3343290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1131" mass="122485" checksum="EE0BB5D599A772C0" modified="2024-05-29" version="1">MTNREPDKATAKGDNGPDHISGQSNKPLSRPAHALTHQQLAQEIGADPLSGLTPDEAKRRLEEYGKNELGEAEGVQPIKIIIAQIANAMTLVLILAMAVSFGIKSWIEGGVVAFVIALNVIVGFFQEYSAEKTMDSLRSLSSPTATLVRGGEAMVVPSGEIVPGDLVEVKMGDTLPADIRLIEAKNFETDEALLTGESLPVRKTVESTFDDTTGPGDRLNVAYSSSTVAKGRAKGIVFATGTFTEIGAIASALNKKDSKVRPVKRKPNGHAGPHRYLEAYTLTLGDAIGRFLGVNVGTPLQRKLSKLAMLLFGIAVICAIIVLGANKFNTRQEVIIYAVATGLSMIPASLVVVLTITMAAGTKRMVERNVIVRNLKSLEALGAVTDICSDKTGTLTQGKMVARGAWIPGMGTYTVELSGEPVNPTKGNIRFAKQMPSEIDFKSTTDSNSATGEITAPTDLLSSSTTRLQDFLSVCSLANLATVFSKESEDTPGTEQWHARGDPTEIAIQVFASRFGFNRLRLVSSGSSPNGDAKWQEVAEFPFDSDVKRMSVIMKNTQTQEHWAFTKGAVERVIGACVDYFDSDSPSAKPKPVTDEFRSEILRNMETFASLGLRVLALASRRLPPSDGTTWNEETPRPLIESHLTFRGLIGLYDPPRPSSASAVHQCHLAGISVHMLTGDHPETAKAIAIEVGILPPLASMSRVSAAVAQAMVMTASQFDALSNSEVDALPVLPLVIARCAPSTKVRMIEALHRRGRFCAMTGDGVNDSPSLRRADVGIAMGLSGSDVAKDASDIVLTDDNFASIVAAIEEGRRIFDNIQKFVLHVLAENIAQAGTLLIGLAFKDASGLSVFPLAPVEIVWIIMITSGLPDMGLGFERAVPDIMARPPQSLRTGIFTLEFLIDMVFYGLWITALCLASFVLRVYAWGDGDLGKNCNEHYSPSCETVFRARATTFACLTWFALFLAWELVDMRRSFFRMQPGSKKYFTQWMVDVWRNKFLFWAIVGGFVTLFPTLYIPVINTAVFKHTGISWEWGIVFIAAGLFFGGVEGWKWGKRVFLRRRARRGARGAAKRGGAGGGKLWKDMDVEEKIFGEYFTGSSGSESEVSVESRGEGEGEGEGATGQRRGEHGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEV0</accession>
    <name>A0AAE0JEV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_425033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681689.1">
        <property type="nucleotide sequence ID" value="XM_062824547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEV0"/>
    <dbReference type="GeneID" id="87861701"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="366" mass="39497" checksum="9621B04E911715FF" modified="2024-05-29" version="1">MAPRLPARCWRQLSLVERSAIHTTTASPLLLAGRITPTTASSSPSTFFPSLLPQITKRGVKYGWSTLPKRSRPTRFNQVTQGLPAPTSGPAAALKRREKTTPLRTGVLAVKKGMTVFMGRTGARIPCTVLQLDRVQIVANKTRAKNGYWAVQLGYYEAKGIPPKQTLAEFKVRNQDGLLPVGVQLLPDWFHVGQVVDVRGITRGMGFAGGMKRHGFSGQEASHGNSKNHRTIGSVGGSQGSGSRVLPGKKMPGRMGAQQHTVQNLPVLMVDNELGIVVVKGAVAGHKGAVVKVQDAVKKAPPPEEFVEATKKLINERFPDAEEKLQAARKLHLELKEARRQGLIDSLIKNGLTEKADGKVAVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEZ0</accession>
    <name>A0AAE0JEZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_464669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681448.1">
        <property type="nucleotide sequence ID" value="XM_062826765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEZ0"/>
    <dbReference type="GeneID" id="87863919"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="494" mass="56689" checksum="ED7C18B050BE47AF" modified="2024-05-29" version="1">MRHRHRHTEQYNMEATDTYSTVTSSPPQAEGHHGTDFTQGFGSFNFMPITPLDWETLDPLCPTKVRERFENERSRHTYQAEHETNDYGSLKHLVEQMSIYDDSPKTKPETCLLLALPLEMRHAIYDQFFIPFRRDGGVYSKPRPQGAASPTLKGLKGGIHFRINEKEWNHERPQRHLDDLVVSDPLITRTMDTLTPWYVRNPGSPVHLFAAITNGAVPAENQPSGWNLPASKMIKYDEWPEASYGKPYEPGPADEEEEEYGEDSDSDMEMSMSMSDEDHQQQSSSHSPPRYRRRRPSRQPYRLVIGPILEKCCDNRCGFTYSADNRSGWDPKLADDMDEVPTPTSAESPESESLCDEMGVKGICRYIHPSRYTNLLQLSQMSPFITREFAARLFFNSVFEFTEGPSLFPHFVRDRPAVLPHMRGVILRVECSANFLDTVTSELEAMLSFLANHEEVNLRFFTVVLSTGLINISRNQTEAGQCFYRFQILQKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFX6</accession>
    <name>A0AAE0JFX6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Glucan 1, 4-alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_494396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682028.1">
        <property type="nucleotide sequence ID" value="XM_062827774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFX6"/>
    <dbReference type="GeneID" id="87864928"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911:SF3">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="560"/>
        </location>
    </feature>
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        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="75614" checksum="F45691B834C8A10F" modified="2024-05-29" version="1">MSTHQSQPSSPPKRPRLSLQIKTFNGSSVRTSRTLAAAVDVKSPTAFNTLSNVYATAVDRSTPIQEHAPATALSGGRPMLRLQTQAGQDGGAAAVSKDRRLQTPYLGPYLDTPLTAQPMSPAIATAQSQMMFPSAMTATPPLSAQPQDQNGPRVFTFESNNNNNNNNNNNNNNNNNNNNNNNNNMASLSLNTTTSQASEMPSCSETPRRRTTFPSNVKLPYTHPRSLRSILRNSPLAPLTCQSPNSSRRQSLRLQEKAARRVAYNSPLCETITTSKYTKSHVDLLAEDSGTPTTPTAKSVPSSSSSSCSSSSDGEELLDQTMAYTGNETRDGGQTPGPYEEMRRRMAGMHASTPISLSPTSGGIRKQQRGGGTGKKREKKRRWVWTIGKDAEDAELEECGSPVVPWTAVRPELSNAVVAEKKEAMVGVPVLAVPMPPKGGRARTRAQTQQAQSWGQGQGQGQTVVAGVVAGNKAAAAVALQIPRLPVPVPGPTSTRRLRPALSLPSMSLPVLPAAPVATAPALPVVQQQQQQQQQQQTQTQQQSPPQQHSQQPEPLQQQSRATLTPEPTLPHIEPQTPSMESVTSMTSIMSQAESLLSEDSVFDSSSVYNGDVEMSDASSVYDDSAGDNESSFGGADGEDGDSNNVYRNYLKVNGNNFSFNGSIGNSKGASGDQPCHSSDMDTDMDMDTPTVGGRPGYAVERLGLGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JG19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_210558</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682239.1">
        <property type="nucleotide sequence ID" value="XM_062821927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG19"/>
    <dbReference type="GeneID" id="87859081"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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            <begin position="218"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="346" mass="39259" checksum="E1363747E61B25C3" modified="2024-05-29" version="1">MTTNNNLADTATLIQLKGEKNLGDWESALWVALDCANLTDYVFSPKDKPEPKDKDSEKYETWRANRARAVAAIHSTLKAENIRTILQINGWDPKNRDPSYHFQLIQKAIAKVTDEARADVLHEYLSLKRQSFDTMESFLSRYNVCRKRVADAGLKIDDELEMVILFNMVRDRYPIEARLWAVDMEKKTLLPPVFLGKLSTIGNSEKRNPTLSVSIQVNNTNNTNKNNSNDKGKDGKDNKDKKRETEKCSTCNRDITKGHKHFDCGHHRNPKTPDCWMCNPEKAPDTWRKKKELMEAKSAGTAAATADTNNGLTHPSSKSSLLYGSVNNFMALSRDDSDSDGNQDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG47</accession>
    <name>A0AAE0JG47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_558074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681682.1">
        <property type="nucleotide sequence ID" value="XM_062830092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG47"/>
    <dbReference type="GeneID" id="87867246"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3345069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="348" mass="39620" checksum="2254E8F5901F03D9" modified="2024-05-29" version="1">MEKSEKQAAAQQAVDILHEISTILNCQLDRRTLSICISMIENGVKPEALAMIGGERVLLGSSKRGPLNEEDDQDQMDIDLASDGKNQRYLAAPNDAISRYHLKLTIYTLRWVIMGFKRLKTRFPPLCHSDSKMDPIATDLEFSSEMSRGRKASRAVNGSGRNGALPLGLRRARRAKSAPNRTERIKYYEEMLRFVRERPMISTSMRPSPTSSWADHDRLEGWDQNEEEEEMDPMELWETERENNKDESRQEQALVKTEVMELCETEGEENKNDSGEQEQQTPLVKTEVIQVQPSSSNQTSEGGNEEASGMKVEVTEMSVSSSRSSSFECDESPYGMENRIEKERRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGD1</accession>
    <name>A0AAE0JGD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerophosphoryl diester phosphodiesterase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_199734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681832.1">
        <property type="nucleotide sequence ID" value="XM_062821764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGD1"/>
    <dbReference type="GeneID" id="87858918"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000705">
        <property type="entry name" value="Glycerophosphocholine phosphodiesterase Gde1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="818"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1226"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1245"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3345219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1256" mass="139097" checksum="0834EF907C5347C1" modified="2024-05-29" version="1">MKFGRNLPRNQVPEWAAFYINYKGLKKLINSAQEAAKNGEPVDLAEFFFALDRNLEDVDSFYNKKYAEAYRRLKVLQDRYGGTPEIVANLDDDEVEELMGALLELRSQFRKLQWFGEINRRGFVKITKKLDKKVPNTTSTQHNYISTKVDLLPFANDTAISRLLTEINKWLSKLGDAQNIDDAKSERSTLSLGRASAKAMLNVPSALLDRLEHAIRKDDVAALENGLKEGNLADSEGPSPSQQPLLLNLLQRSISSRSRDCIVFLLKQVKSLDEPNDINERNCIHRLVIHIGRTKTASLISSEPEAESYPFPRTGVHYAQPYLTPATSPLSAPRGTTLKESKLLGHDDEAIQLLKYLLENLRPDQRVALIAKDAFGRIPLHYAAQFGFVVVCQIIMRKMQDWGQFNVENGIDAPEWQDKDGNAPLHLSVIGGHPLTTKALLQGENWKGVNDHQAEMRRAISKSSAVLALATKANSKDIVELLVNAGVDINWQDNSGETALHVAARFGHDECARVLLKGTEQQKANLELAEKNFAWTPLHIAAVDGHLGVAQLLVDAGADVDKLDSSGWTAKEHAALRGHCEIARLLSAHSQAPEDVGGSSSDGDDEKSSTTTPYPETENALAASLGDRRSNAPGTSRPAEPVKTFGHRYLKNESLVLVSLGSMDMRKGIEAIKLDKVPLAEAHTTQLDTALSVVVSAQGAQGDPTMIDLPVHENISTEPILFTTRDASNVRLFFDIVPTYSGNEKNKVGRGVALLSSVRPTVGTKRMNLQGDISVPIMGSNFEVIGTVNFNFLVITPFSHPKMEVTSQQTYWKKLDSTMVIGHRGLGKNVVANKSLQLGENTIPSFIAAANLGAQYVEFDVQLTKDHVPVIYHDFLVSETGFDAPVHTLTLEQFLHINPDSYRSGHPHHHGHHAPAAQQAQHRQLKKFRSNSPGPRQRSMSMDLLPGDGKDLMEERMKHTRDFKEKGYKGNSRGNFIQAPFATLEDLFRKLPESVGFNIEMKYPMLHESEEHEMDTYAVELNSFCDTVLQKVYDMAGQRHIIFSSFNPDICLCLSFKQPNIPILFLTDAGTCPVGDIRASSLQEAIRFASRWNLLGIVSNAEPLINSPRLVRVVKQSGLVCVSYGTQNNDPSLVQVSFISPSPFFLFYHHHYRNQANQLSFYLQKQVKEGIDAVIVDSVLAIRKGLTRDRGNVSGGGGSNGKELQERVREVEEAIKKERIEEEGSSAEGSANGDSNGTMSGTSTKEIEETLRALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGU7</accession>
    <name>A0AAE0JGU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_152164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682720.1">
        <property type="nucleotide sequence ID" value="XM_062821090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGU7"/>
    <dbReference type="GeneID" id="87858244"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3347638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="508" mass="54801" checksum="9B126779F536F15A" modified="2024-05-29" version="1">MAPGDTVLLTGTTGHLGWAILRFLLGEGYYVRCAVRKAADEHTIRARPALRRLNPASKLDFIVVPDITTPGAFVAAAEDVAYIIHTATPLPKSARSINTDDARETFIKPAEAGTLNILDAAEQSGTVRRVVFTSSIAAIVPISQMEGEEAREQPVLPEDRIPVDPGPYKSEFAAYAASKCRALQVAEEYMETERPFFDAVYIHPGFVLGANTAATTEKEAMKGTNSMLAALLLGHNQGVYAGVSVHVEDVARVHVEALSPKILGGQSFILGEQVRWTDAIDIAEKEFPELFASKLLTTSGYYQTVSIPIDTSLTRDTFGMDFISFADQVKSMVQHWAKVRQPHGTPSSTASSPPTESLGWESAEMAEDETPIAYSPIPSSEDEPAIPDVHLSLPTVIAGLEEHDYGTAEVIPPATEEETWEEIIQRHMIPSEVFPSGGESGGSNWSTASYHTEGVTPSASGDEEGPAIYYDSDARQDSEIHGDDGVIHIAQDVKERPAVHENGADGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGX7</accession>
    <name>A0AAE0JGX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_423605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682734.1">
        <property type="nucleotide sequence ID" value="XM_062824470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGX7"/>
    <dbReference type="GeneID" id="87861624"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="458" mass="51357" checksum="E384F7C0DA9599DF" modified="2024-05-29" version="1" fragment="single">RLETSSHTKTVQPQPSQPASSSQNSNSDISLVSSTAEHPRPLPDLEMATNFIEIDKISKSRELTSNYTITPTDDQIMYKARATVDRILILHPARQDRGEIIKAIETLYNHFHWMWIVGEEKDANLELRVKLLHRMRVVMHGEFMSGIDSGIFIDRQSGVESFSATATCTVHSRWDGMPCPVTPQAFINRPSQELHKGRLWIPVLNYFLFFIALLTSNPDEVSTPREASGPGTSRSTVPASTSNTRATAVSAPRHTLLPMAFRIIPINRITREITQNSTVIPIRPQIALKAREVIQKALMDGTQVETIEMALTKLLSNFNYLWGWGRYKDKWVGVTVGLLNEMMAVLKGMRLPLPLPVASIGGRNLSPVFTCLWSLQRFYDFLEKGFLYPDVVVLFRLRCTCTANVLQGIMRCIIAGFSSNCRDVPCSSHTPVRQSGPRTLHSHSPPALGDILQRLCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGY7</accession>
    <name>A0AAE0JGY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_509193</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682117.1">
        <property type="nucleotide sequence ID" value="XM_062828289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGY7"/>
    <dbReference type="GeneID" id="87865443"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="45"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3345504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="447" mass="48181" checksum="2151B9971F95252C" modified="2024-05-29" version="1">MFKLGRNRALASAFAAASKAPLTSRLPSVSQQQRRALSIHEYLSADLLRKYGIGVPKGDVARSGAEAEAIAKKIGGEDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPTEAKMFAEQMIGHKLITKQTGPQGRLCNAVYICERKFARREFYLAVLMDRASQGPVIVSSSQGGMDIEGVAKESPDAIHTTYIDINVGVTDEMARGIATQLGFSEQCVEEAKDTIQKLYKIFCEKDATQIEINPLSETSDHKVMCMDAKFGFDDNAEYRQPDIFKLRDTTQEDPDEVRAAQSGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGQPANFLDVGGGATPAAIREAFELITSDPKVTAIFVNIFGGIVRCDAIAHGLINTVKSLDLKIPIIARLQGTNMEAAHQLINDSGMKIFSIDDLQSAAEKSVQLSKVVKMARDIDVGVEFTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH33</accession>
    <name>A0AAE0JH33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_147740</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682456.1">
        <property type="nucleotide sequence ID" value="XM_062821029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH33"/>
    <dbReference type="GeneID" id="87858183"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
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        <location>
            <begin position="40"/>
            <end position="242"/>
        </location>
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            <begin position="238"/>
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        </location>
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        <location>
            <begin position="256"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
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        </source>
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        </source>
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        </source>
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            <dbReference type="Pfam" id="PF03443"/>
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        <source>
            <dbReference type="EMBL" id="KAK3347374.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_154464</name>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JH82_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_460529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062826537.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87863691"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="65" mass="7143" checksum="90520879CED72964" modified="2024-05-29" version="1">MFNEPQKKPCGPCEVLQSSPLIDCVTLFLHLLLIGSKSNIYLGIFPIPLSLALALVFSRFPQVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHM1</accession>
    <name>A0AAE0JHM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_587580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682736.1">
        <property type="nucleotide sequence ID" value="XM_062830982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHM1"/>
    <dbReference type="GeneID" id="87868136"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="318" mass="36653" checksum="2DC306167068FA23" modified="2024-05-29" version="1">MANEQEILEASSILTSMASSAVHRLQTPVDDTTSPNIAAPVPPQTRSITTLWHPRGRLPFQFAKALSADQLNFINQVATELIGEARSLSDLHELRVDAITSWGAYESCAPEIFKDEVVVKKMILCYEVIEQVDDDLDHVDREQHEATLMPNVPAHDKPETDKTPSPINVMAPNVTTRAQRRRRKEAKRAAKRAAQELREARRQYDVENPGEIRKRVSIKKHREIASRTVQKAAEDGEEALRVLQRQIWIQRQWYGLSTYTFPLRYEHHCRLLYLNEHLAQIEAKLSMYEEEVNLKPRRSERLRQQGLRAIVKLGRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHQ1</accession>
    <name>A0AAE0JHQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dehydrogenase FUB6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fusaric acid biosynthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_547256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682507.1">
        <property type="nucleotide sequence ID" value="XM_062829501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHQ1"/>
    <dbReference type="GeneID" id="87866655"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="97"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00083301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3347425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="362" mass="39604" checksum="BB7716BA40C51D23" modified="2024-05-29" version="1">MPKVQNKTLIFKKIPTGYPVPGEHLVVEDRGFDTDAAPPPGGMTVSILYASFDPYQRGRMRDASIKSYAPAYPLNGPVTNDTVAKVLKSDNPDYKPGDLVVAHLPIAEYAALTKEEVGEVMGGIVGQLVQTKIDNKYNFKDLGLFLGPLGMPGLTAWSSYKEIGKPKKGETIFISSAAGAVGQVVGQVAKREGLKVIGSVGSDEKLDFIINELGFDGGFNYKKEKPLDALKRLAPEGIDIYYENVGGEHLDAALETLNLWGRIVACGMISQYNAKPEERYGVKNLIHVFAKRLEMRGFIVFDKDFGPKYCKEHQEQLSKWIAEGSVKVKLHVTEGIDNAAEGLLGIFQGKNFGKAVLHIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI80</accession>
    <name>A0AAE0JI80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_441326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682807.1">
        <property type="nucleotide sequence ID" value="XM_062825519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI80"/>
    <dbReference type="GeneID" id="87862673"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="667" mass="73261" checksum="1D92DC68AC0D7A57" modified="2024-05-29" version="1">MATPSGQQVHNMAFNFYGWAVAIPQHVDGYEVIKLMTRAPSSRPSIKAISDRNLRIRRDLQFTDQELQTHNDPTTGAEEVLLVGFTVADLPDAAKKSASKKLGTAVGTVVAPDRTIAVHDDNRLIMVVTPISGLDGQMKFYGLVDQQDEDGLCTPQIMDQESCFYLPIFRGGVESASKREVKKQWNKNIRDIVGGGSEVSPDVTGSASATADDGGERQVSPEATESPKDSEGQASPDAAASVRNDERQVFRELSTRSSRTQSRLRPDHPQWQAQKLTAQLMPLLHDVIGIEQTLKEVITAADETVTSSMEEVAPGNGEVDPHSEEEIRERSVSTLLAGGFDKMYRDLVWMTEVKRLRGDQRVVNTIRQIVDTTLTPLVSRLREMERLMAPEEDVGSDNGNSENVDSEHSDSDDGLNDNVDEGNDDSADGTLANNRDSDGSPDSSQTDEESDSRSDTSEWSGIHDSEDDVEMGEDEEMEDDAEMEDHQEMDGDEEVEEDQNVEGDKDTEDEEETEDNEEMSDQEVEDEEMDDDVDLVHTWNESIRSNHSPDQDHDDAASSSISAEGAIDVANEINEDGSLCHSVSSPVLGEDIVPIAAMAGRVADNDDDDEDEELAIDNQFSTAKRALTIVYYRGDRIEVKYYISKSREGGCLGGSGLKGSNTGFLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIB6</accession>
    <name>A0AAE0JIB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_508334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683520.1">
        <property type="nucleotide sequence ID" value="XM_062828212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIB6"/>
    <dbReference type="GeneID" id="87865366"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3348438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="189" mass="21602" checksum="4AA83E2CED4BA2F7" modified="2024-05-29" version="1">MSASKASRLGEETRIEKVNAELVVLTYGTIVAQICKDFENDYAEVNKQLDKMGYNIGLRLIEDYLAKSNTMRRCSNFRETAEMIAKVGFKIFLNVTPTITNWTSDNKQFSLVFDENPLADFVELPDDGRAQEQLWFSNILCGVLRGALEMVQMQVETHFISDVLRGNDTTEMRVTLVRYIDDELPPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIL7</accession>
    <name>A0AAE0JIL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_176413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683534.1">
        <property type="nucleotide sequence ID" value="XM_062821443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIL7"/>
    <dbReference type="GeneID" id="87858597"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041902184" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3348452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="758" mass="83538" checksum="95ABFDEF2F863949" modified="2024-05-29" version="1">MKLWSARPLAVLASLATLVAPSFARDRELHSNSLNACQENSGFTASLFDVSFFPDNGTVNINMLATSSIQGYVVFDIRILAYGYQIMHEVLDPCNIGIGLGGLCPMNAGKMGNPFRLELGPEVKDRIPGIAYTFPDLDATVKVYVNMTDGEMAGETVACIEANVSNGMTVDLIGVKWATWAVVFLGIMSSVLLSGLGYANAASHVASNTLSLYGYFQAQAMIGLCGVHLPPAVRAWTQDFVWSMGIIRVQFIQDILTWYQRATGGTASTVLNSLETVSVQVEKVKRALPAEYVDPAINLFKRATAMLPRAAAHIGSRIAKRANVQTSFGSYIVYGIQRVAFRGKIESTNLFMTSLTFFYIFVVFTAILVILFKVGLELFAKMGWVKGDAFSDFRAGWITVLKGILYRVGLVGFPQVTVMCMWEFTQNDSPAEMALAVFFFFGLLATLLWAAWRVIRIARRSIALHRNPAYILFSDPQALNKWGFLYVQFRASGYYFIVPILFYIVIKGMFIAFAQANGTLQAIALLIIEGGALITATVMRPWMDKSTNTFNISICAMNFLNAILLFLLTDVFDFPPLVIGVVGVVLWIANAVVCLILLLMLIITTSMTLFHNNPDTRYQFMNDDRTSFMKSNPQLHTQSELEALGVTARGESKLYTKSPLSFEDDDSEVSGPSNPLNRPGTADSNTGNPHIHSNRYSGRWSNDPSLRKDEPFVRHRPSGSIQTPSPMTDSASSLPGGRISEEKPHNTASPWQRGAGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIN9</accession>
    <name>A0AAE0JIN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_538757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683251.1">
        <property type="nucleotide sequence ID" value="XM_062829099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIN9"/>
    <dbReference type="GeneID" id="87866253"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042001264" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39506" checksum="CFCF7A6FF82DA07B" modified="2024-05-29" version="1">MRFASAIFTLAAATLSLASDPSDCSTTSKEKTGSDFKLTEQADNVNVASLSKIYTAAGKKVSVADVFNDGNHQMTTDSSGRKLWQHTSDFNDEDTTKWVPQGITSTADALVRSVRVTFVNRADDTYRHALLVYPHASDNFREVPVHAGGIMWYGNTLWVLDTYNGIRVFDLTNIWQVGDGEDVGKVSSGVYSAAGYKYVIPQIRWYKWSSSFEFRHSYMALDRTITPDSLIVGEYQTSTSDPIRLVRYELDYTTRRLKTDSSGVSKAIWAYCVNIERMQGAVSANGKFYLSRSKGASKGDLWAWVPGGVAKQNAGFYPRSPEDLSYDKRNGGRLYTVTEAEGVRYIISSAVSSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJD2</accession>
    <name>A0AAE0JJD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_85306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683656.1">
        <property type="nucleotide sequence ID" value="XM_062831485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJD2"/>
    <dbReference type="GeneID" id="87868639"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="227" mass="25868" checksum="06DE2B9DBC64C18D" modified="2024-05-29" version="1">MHGDRGLGWRRHSPEHLAVCYTRRAFHTYLWVSGLFPVLLAVQCTLIMVHRARHSSHPFRIWKVPTFSFCSYVRLLPYRSRAFLLITGARQLPAQAMDSFEATSAVNGRRRLFAPGRSISSDTYDIRKRSVHISFSQGAGSVAQGSRERVLLSGNINVDMHAFPWLNDAIIPMSSQIRSITVSIDKYAHPRWKTKKYGTSFEVENAVAVKLYILSVCVTWARFLNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK38</accession>
    <name>A0AAE0JK38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein trafficking Pga2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_456014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684113.1">
        <property type="nucleotide sequence ID" value="XM_062826265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK38"/>
    <dbReference type="GeneID" id="87863419"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022909">
        <property type="entry name" value="UCP022909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="150" mass="16957" checksum="FA1650859D48EF8E" modified="2024-05-29" version="1">MDGVANVITVLGDRISNNVRGTFASMTAEKWIRLIIIVGAYALLRPYIIKLGGKAQMKQHEEESAEAIRGTISPNELRGQKAMVRLPGEDSDSEDDEALNGETSAADWGKKARRRQRMVIKKLIEAEEDRLRESKEEEEDKDIEEFLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKC6</accession>
    <name>A0AAE0JKC6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">B0H65DRAFT_517945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683872.1">
        <property type="nucleotide sequence ID" value="XM_062828688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKC6"/>
    <dbReference type="GeneID" id="87865842"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="34"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3350577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="529" mass="58976" checksum="426B6CBDCDD5C2C8" modified="2024-05-29" version="1">MPTTTDTVPVGDFEQQTHKFLEWFTSQPGATFHKDIKLVDLRDKSAGRGIIATAPIPADTTLFTIPRPSILCAATSPLASKLPFLFKGPAEPTVAEETENHTADDDDVPAAEEDQEEDPNSQDSWTLLILILIHEYLQGSASAWFPYLSVLPQKFDTPMFWTGEELGELQASALVPKVGKEEADEMIRTKIVKVVKENEAAFYPADSPAAEKKKLSEEELLALGHRMGSAIMAYAFDLAKEDDEDEEEEDGWVEDKVAAQNDTMGMVPMADMLNADAVFNAHINHGEACLTATSLREIKEGEEILNYYGPLSSAELLRRYGYVTKNHARYDVVELGWELVEGGLKEMVEGVKGRKKEVDWSKVDELLEEEKEEGEWEDSFVLERQSEDPDSEGQVHGEAEFLGLPEELEEQVKVYLKVVKKVVGTGDRAVAEALGNKVVKKEILLGGVRKALEEREGQYATSLEEDEKVLQGIEGGRPTTRKEMAVWVRAGEKRIIREAVAWVQREEEELKQAKGGEEKDEPAAKKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKE5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684326.1">
        <property type="nucleotide sequence ID" value="XM_062826316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKE5"/>
    <dbReference type="GeneID" id="87863470"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="94" mass="10482" checksum="3FBBBA119D12BA04" modified="2024-05-29" version="1">MIWVRSWSLLVWLSNRTSSPSVVVMRFSKIPSARRAPSGSSFSLIVVPLLHSIFRLCSPTSAYVATHFLHTSYVATHHDMTTKGSSTNGYHCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKG2</accession>
    <name>A0AAE0JKG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_546128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684356.1">
        <property type="nucleotide sequence ID" value="XM_062829428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKG2"/>
    <dbReference type="GeneID" id="87866582"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042131164" description="ribonuclease T1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="153" mass="15828" checksum="6B02DE8BE2220F62" modified="2024-05-29" version="1">MVQLLSAFISLLSVVAVSGAAIPVAAPEAIVDVAVEPTAETTTGDFTAQACQYTCGSVCYTSSAVTAALNKGYGYYSSGSTAGSSTYPHQYNNYEGFSFPTAKPWYEFPILSSGKAYTGGSPGADRVVFDSKGNLDMLITHTGASGNNFVACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKN5</accession>
    <name>A0AAE0JKN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_117959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684729.1">
        <property type="nucleotide sequence ID" value="XM_062820679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKN5"/>
    <dbReference type="GeneID" id="87857833"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="32"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="498" mass="54314" checksum="3695CFA7116B96C2" modified="2024-05-29" version="1">MKVSVAILAAAGGAEAFWRMECRGRLGVARLDPLVNYGEVGSHAHSVHGSSGFSDKAEFDDLMNGDCTSCAVTQDKSAYWTPSLYFQHANGSYELVQQVGGMLAYYLLYTDDANPSSGIKAFPPGFRMIAGDTNRRNYTVGNVQDADPQKSDWASLGQTSQTDLTQRAIGFNCLNYGKQPEGTLYRHYMPDKDYLDANCADGIRAEMMFPSCWNGKDLDSDNHRSHLAYPDLVMSGNCPKGFETKVPSLMYETIWATNNFIGQPGQFVWANGDIQGFGYHADFMNGWDEDFLQQAVETCTNDSGRIQDCPIFNIQTEDQQGQCTFNNNAELVKMFKTSLNEKTTGLIGDSLPGGVKIAYGPEPANAANAGSHSTTVEVPTATYSQGATVTNGNYMPGGIFKAAKVADVNSPVVPSITTEASSVITEAPTVIDQDGEFTAIRTEYITNGNVVSMVIIKEALEYVTVTTTTVTAVQTVQARQYSQYMNRHKVRHAANHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLI8</accession>
    <name>A0AAE0JLI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_128994</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684943.1">
        <property type="nucleotide sequence ID" value="XM_062820779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLI8"/>
    <dbReference type="SMR" id="A0AAE0JLI8"/>
    <dbReference type="GeneID" id="87857933"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3351648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="138" mass="14945" checksum="BEB7249E547D2EAA" modified="2024-05-29" version="1">MGKRKKSSRKPQGPRRNDPLPTVFTCLFCNHERSVIVKLDKKAGVGYLDCKICGQKFQCPVNYLDAAVDVYSAWVDAADAVAQEAEASAKAASYSNSRSTGGRPAASSRRAADIDEDDEDDDRGYGGSGVEVDDDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMP8</accession>
    <name>A0AAE0JMP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_413646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823857.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87861011"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMU7</accession>
    <name>A0AAE0JMU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062829473.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="10"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="151" mass="16231" checksum="CEABEA0EB4DF4FBA" modified="2024-05-29" version="1">MDADKKSPIPATAPSTVTVTPEAPAQQSQIVTETTGTGAIGLTITTVTGIAGTSTRTITGPDGTVFVPPPIPAHPGCELSPQMAKAVKDYSIEHCCDYIKAKNLLRDKIIAKVLENTQEKLMELLQNELDRMSSEEEDDDLDLDFDMKEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMY5</accession>
    <name>A0AAE0JMY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_504547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
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            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="LaButti K."/>
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                <person name="Yan M."/>
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                <person name="Labutti K."/>
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                <person name="Yanf M."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <source>
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        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="LaButti K."/>
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                <person name="Ng V."/>
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            <strain evidence="2">CBS 560.94</strain>
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                <person name="Hensen N."/>
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 560.94</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
    <sequence length="361" mass="41171" checksum="F80A751C932A5BC6" modified="2024-05-29" version="1">MGWLDGWFGSSSSSDESDPLGKLDPKLREFLARESPVKYTTQQEQEQQQQSQHPSSSTPAKAPVPTATATAKALATDKQQQQQQQIQDEQQQPAVPRASLYQDGRYAHLWKTYRPQYEIEAETKTDHEKLMDVLEGFKERKAMIGKAALENCAEEQLDWNNCMKHGSWADRATMCRDTVRKFERCYNMQSKLLKALGYLQTYDRSPEVDEDIQMHADTLYHRMLDQEAEIEKCKAEGRPVPAFPSLFENSTYKVPVYPTKTSTVPQPGATAAGAGTEPGKDPYEPSQAIVESWQEKLAKLPETERVAEEEALRAEHRAKAIMAKNLQELWNEQSKEREQRRMEGKETIGDKIKRVLGTPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNU6</accession>
    <name>A0AAE0JNU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hsp70 family chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_563441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686394.1">
        <property type="nucleotide sequence ID" value="XM_062830231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNU6"/>
    <dbReference type="GeneID" id="87867385"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="68374" checksum="1F27C8DB957100E1" modified="2024-05-29" version="1">MYADSPAIVVSVDLGTTYTGVAWMTPKTPIQVISDWPGSGDRGERKVPTTLVYNANGTLSSWGFMCADDELEAGVPGGGKVRREFFKIFMDADTLADAQQHGLTSAPQSVFEAQQFVTDFLRQVYAHVKESIETQIGRRGIGNGWTDLAVEFLFSVPTTWTSQSIVNSFKKVIREAGFGIEGPKHSAQVDLTEAEAAAVATLKTSAVSFGMGSVFLTVDAGGGTTDLALMQVTSSNVAVPQMASLHAVNGVGIGATLIDRLFIRLVSQRLAACPDAAAHIPPGLPLRLARSHQFRTMKHKFGERAYMQALFRIPIEGLSYNFSHAGLGIENGRMVFTLQEIQSLFDPQIEAIVNRIMGELEWLRTMGHLHQVQYMVLSGGLGSSAYVRDQLQQRFLAYQHPNASDQVAVIPCNDPQLVVVRGLLLDRQQRWESGGATSVLSTRIARASYGVVVQEIYVPAMHSNEDVRPDPFEPSKKWAVNQVQWLIKKGDLVNPNAFLVKSFQIRLAATETTRAWKSQIVVSHHDPSQLPSSMKQDGAYKLCEVKSNLEGVQQDQLVKVNKRGTCWSRGVTFYICQFDVRVIVAPADLRFELWFGGQKFSGNHEPISVDWDHEGSKVKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNY2</accession>
    <name>A0AAE0JNY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_505075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686490.1">
        <property type="nucleotide sequence ID" value="XM_062827965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNY2"/>
    <dbReference type="GeneID" id="87865119"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="274"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="448" mass="48599" checksum="47A42C9052C7A427" modified="2024-05-29" version="1">MALSADDTTLSAPGSSKEMRTHDDAVATKRGDRDSIGGHSRNSRSRTRATAAMSNSNPVAPKKKKGGFLAIFGCCGVPDDANGLDTPVPSHKLDKIPPRPATASRRTATPSEQPTASKSQLFEKEPVQQSQPTQEQSKNGKRVSGTSTQDQSTVGERDGESKQTTIVGPGSSSPLASVEPPQQTNKEVEVVEEVVNEKDEKGDVQMPDAAEESQQASHAADATTEESYTNLPPPPPGPIPAVPTAPTSGALIESPPVFPPDQPQKFLLPPQAPEFKGKKCLVLDLDETLVHSSFKILHQADFTIPVEIEGNYHNVYVIKRPGVDQFMKRVGELYEVVVFTASVSKYGDPLLDQLDIHNVVHHRLFRESCYNHQGNYVKDLSQVGRDLKDTIIIDNSPTSYIFHPQHAVPISSWFSDAHDNELLDLIPVLEDLAGANVQDVSMVLDVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ71</accession>
    <name>A0AAE0JQ71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_57447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830581.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_71"/>
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        <property type="entry name" value="Glyco_hydro_71"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042264551" evidence="1">
        <location>
            <begin position="22"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="498" mass="54587" checksum="D1F10865911DE310" modified="2024-05-29" version="1">MRYSFSVLTATALALLPFAQAAKEVFAHFIVGNAPNYDMSDWQDDIRLAQDASIDGFVLNIASQDASNDNSLANAFRAANAANFKLFFSFDYSSQAPWSKDAVTALINRWANERSYFKPDNTYRPLVSTFEGPDHAEDWHDIKGKTNCLFIPDWSSLGAANAATTAGSVADGLFSFDAWPKGPSAMTTEVDEQYRTALNGRPYIMPVAGWFYTNLPGWNKNWLWKGDELWDTRWQQVIDFQPDFVEILTWNDYGESHYIGPVREKSLGLFQSGNAPLNYAENMPHDGWRKLLPYYIQQYKQGGKVQPTTPTTTTIIAPTATAITTVIRTLTTIVTAPASSQTLVVAFKAAKVVVAQENLVVKEEAVVAYYRTNPAKACNNGGTTGNDPNYQQVYPPEDLLQDNIFFTALLAEPADISVSIGGKDLNAMFSKKMPQVGGAGIYSGKVLFTNSTGDVVVSVSRTLEDGTTLLIAQAKGGPSITTECVDGMVNWNPAVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQE8</accession>
    <name>A0AAE0JQE8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">B0H65DRAFT_59060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687189.1">
        <property type="nucleotide sequence ID" value="XM_062831072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQE8"/>
    <dbReference type="GeneID" id="87868226"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="753"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
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        </location>
    </feature>
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            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
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            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="891"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JQN6_9PEZI</name>
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        </submittedName>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3355675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQN6"/>
    <dbReference type="GeneID" id="87861043"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="175" mass="19879" checksum="0CE5D0D1D34D17C8" modified="2024-05-29" version="1">MNQPSQPSQPSQPSQPSQFTTSTSVNVPIEQRPTVTGLCLSCHQIKSLATYNLPFFEPSSTIMGKKKRPAPPQRYDVVIRWKNYFGAGELEDWQRLCQDLGLDGDFASKRKCRNALKSINVNIWDFLDAVEVGTIPQMFLTKKELVKYTWKTGRIFPRDEAKDMGPVAALLKMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQP3</accession>
    <name>A0AAE0JQP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_555084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687086.1">
        <property type="nucleotide sequence ID" value="XM_062830011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQP3"/>
    <dbReference type="GeneID" id="87867165"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="545" mass="60540" checksum="810298884D22A23C" modified="2024-05-29" version="1">MIQESINKLFCILESNKKAKASNDIDDTLITKQLNLRNPATTQQTVSSTSKIIETEYKCGHSTTTSRPCEKAREPSGIWDSCFSKKPKYCSHPREEKKEFEGLCDKCRERAASKTRQDRSASKSRKPLGRSASVREPAPAHNENIRLVKGTATERHEFFLQEGAPSRGRSKDISKDKSRDKSRDKSRSKSKGKSKDTSRRPPPPLAARPLAREALNKGKGRSSSVPPHDKAAVPPPRGSITNYKTKPLPPLPPNSSKSSKIVGSSTSTSRSSSRNGRPLVAPPRHGPYIPDNAASAVPAPLRPRRPSESQARLPRGDKNAPLRESQRFVNPGPAPPVPYPVPQACYKYDLPNIIAAELRQEQFERERGRDPHPKPVPQQQRPSHQPYIKVGFRPHDQGQQQKGQVSQPHHYPPNASRHVEIQAPVPRRKLSKTRLNDAADNFFGGGGSSRSASKTRERSASFKHDKHDKNHGKKHQKQPSTASSFMNKIRAGLGYDDDEDSDSDESWACADSRAIERGESTHQPSTTTSRRTSYHAGDHYMHGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQX5</accession>
    <name>A0AAE0JQX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_564850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687253.1">
        <property type="nucleotide sequence ID" value="XM_062830267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQX5"/>
    <dbReference type="GeneID" id="87867421"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="44"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="437"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="661" mass="73950" checksum="C893456B90043CE3" modified="2024-05-29" version="1">MPPGILEQPAEEQQGGDSHMTNAANDSCVDRLTLLRSMPEPPVECQVCVVGAGPAGLMLACNLGRFGVKVEVVDDRADQTPVGRQVHTPADGLQPKTIETFRQMRLADPLLQRGVRVYDIAFWRSTTDEPLHRLGREIHYPPIIDVLDPYILLVHQGMVESLFIEDLKKRGVEVRRNTAFDSYSVCDGNNGPLQVNCLTNVTQDRKTILTQYLVGCDGAHSKVRKSIPDAKPIGLSQPSLWGVLDGELDTDFPDIWSKTLVYSQEHGSILIIPRERNMTRFYIELKSSTKGDRNMLGQDFVMQRAKEIMAPFSVKWKYIEWFGRYQIGQRVANRFQDSHTRAFLAGDASHTHSPKAAQGMNTSMHDAWNIGWKLNFAARGLAKPALLESYEEERRKIALDLVNFDYEHANQIAGGDAVALAENFKTNVRFISGIGAEYGENAINMVEPQSWVMGDAKPGCLLPPAKVTRYLDSNPVDIQLDIPMLGQFRIYLLMWDVHQSRIFLDGFCAALASPDSLVNQLSAATNISYAKQPRLPAPEDIYLRPERYTAVSHLFTFGLITTMPKSEIEITDLPALFQDSRWTFYLDDIPELDTRGQLCTNKWLGSLGPGEVAIVNVRPDGYVGSIGRWDSSVDDAGEEAAKWLDTYYDRFLQVPPSPAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR06</accession>
    <name>A0AAE0JR06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_47202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686797.1">
        <property type="nucleotide sequence ID" value="XM_062827127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR06"/>
    <dbReference type="GeneID" id="87864281"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="682"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="933"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="459"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3355419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="968" mass="105753" checksum="B6C11C0F3DFEDB94" modified="2024-05-29" version="1">MVSPQDQDEIGGPSNTLSGRDSETTLQGGNGVESGNGNGEGSSSTSPNASANISVIPTPQPEQPLLTPQIPHLQLPKGKEKKRVGFLSDRPPAQAGGPPAPQVVVTPDGQEYAAHDYFSSPINDYDFATTPPHPFGPPAKRDSFNRDEVTAALAEILRPELHNQDSSAHPVRPRPVLRKNTTTVPDPQPDMLKPPHRSEVEARNRADKLAHAVGTSSAGASRRSSFTGNDTDSGDEATLNGNVPPIGISISRDFEAQEQDDSHSLRARRKSQQVANELVRNHTRRISAFNALNRPQTALSTTVSGATTPIPHDVDYVPRPDKYRGGILGNLLKLYNAEENTGATTPGGSSTMTTPSQTPNRTPTTTPPTSRPSTPKSEKDRGRPRGFRSTSTSRLMESSFMFAVPSAAREVTEAADKVKQEKDKTKRRSRSRSRLRADRQKLEEFRITKHIAEIISRHRYLLKLCNALMMYGAPTHRLEAYMRMSARVLGIEGQFMYLPGTMIISFDDSNTHTTEMKIVRSNAGVDLGKLRDVHEVYKEVVRDLISVDEATARLNDITNRKNKYPTWLRVLLFGVASASVAPFAFEGRYIDLPIAFILGCMVGILQLYIAPANELYANVFEITAALLTSFFARVFGSLHNGELFCFSSLAQSSIALILPGYMVLCASLELQSHSMISGSVRMVYALIYSLFLGYGITIGSVIYGYMDHNAVSAVHCRIGPEWYSKRPDQNYYILFVLPFTLCLCAINQAKFKQLPVMVVISLASYCVNSFSSRYFSGNTTLSNTLGALCIGVLANLYSRMGRVVQNKFLDIWEKIFEPRIARLKGNHRRLYSTEGGSNNSFRKDPDPEMGLPAEKPAAAPHKHARKIGYGLAAAAMLPAIFVQVPSGLAVSGSLLSGVASADQITRNETLSADGQTFTQGTQTADLNSTAFNVLFSVIQVAISISVGLSLSALIVYPFGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR72</accession>
    <name>A0AAE0JR72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_454337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687593.1">
        <property type="nucleotide sequence ID" value="XM_062826191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR72"/>
    <dbReference type="GeneID" id="87863345"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="267"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3356216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51652" checksum="53FBB135DE5B110F" modified="2024-05-29" version="1">MGRKDTNPAWREANIWEKPEPARRYSTWGTTTTNTWASDEVDPEFEAQIQTEEEKTKKKPSVWRSLACGMKFPKMGWSFGRKKNKEGAAAENPYAQQPAADPYANQHASPAQSQATLSSTTSSGPRPGGLPSGPSPYQNQQAPPPYSAGGPVQQPPAAGRYTNERFGTTDKYGDNRYDTPSSSNQNRYQPSNDSKQQYPVTYGDNKQPGQIPPDGYEPSPQELYGNKYGVPQEELTEEQKEDVEFTDVRNEIVNEQNATIDTLDRTMETSYAALANMRNARQQLREQNERLLYAKGNIDHGAAQARQAKERVKELERVNRSMFLPVGHSKKTLDRMDRDRLQAELEEKEIREQNARELYKNRAQAQMAGMKPKKLGLGGGADNKKKYALEDDEEMDQNENAINTKIALMEQVAGELKEGALDIGAGLDLSNRYIETMTENTDRLNIEVRRNKMALERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRA9</accession>
    <name>A0AAE0JRA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell cycle inhibitor Nif1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_545447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687624.1">
        <property type="nucleotide sequence ID" value="XM_062829376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRA9"/>
    <dbReference type="GeneID" id="87866530"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000455">
        <property type="entry name" value="Cell cycle inhibitor Nif1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="80978" checksum="6F8F4DED6447B16E" modified="2024-05-29" version="1">MSSTPRRPEQLDIRSKSAMSVSRPLRSPRLHVAGEAPPELSPLDAFAMQSRLLAKQLEESARQGRRMSRLPPLTTDSPLIVQGRSEYFRSLSQDSGSDEAYTPQHNVGLGLRHEVDEDVDSRPKSMHPRMSRIPPTPIESSIPMTARPNFDALNRQHSNESVEGEIFLGIGARREESPQPLDRSPEAERRSASAMGTRESMARSPPPAPTLTRAMTSPDYIQKQGSFEHGGLLPPRPLFPKRSSSIMSSTLESTDEDGLGSLGTSFHSQHSQGSRKMSTSSSILSPLGRSQRSPSISSDMSVLQKPSFNFSRPMSRAETPSFEFPARQPSSDSHTSFVLVDNEAHTPVSMNGDGFPDPDGNHSFHNVQFTLPRGKSVRRAEDERPEVGTPLRQVTTNERPPLPSSNELHPRSPVSGQPPPSPSSSVGPRLSEDRLRRIPSERSNVTLEVPRSASTRQPSPEAIGRLSTDSALERARPSTSPTPDSNQNKTATPTATAAPSIAATNDTAATLKATRSLGQSTGHHTMAEMTAEEHVSKAVALHEKGALQESTWHLSHAAKQGHPTGMLLFALACRHGWGMRPNQREGVEWLRKAAASVNLELQQDDDKTKEGKSVDKVEHKARKAQFALALYELGVSHMNGWGIEQDKVLALRCFEIAGSWGDIDALAEAGFCYAQGIGCKKNLKKSAKYYREAEAKGMSMVGNSWIHKPKYADDAKDSKHSRTKSKTRKGLFGRKSSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJP4</accession>
    <name>A0AAE0MJP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_543158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677252.1">
        <property type="nucleotide sequence ID" value="XM_062829215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJP4"/>
    <dbReference type="GeneID" id="87866369"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3335086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39765" checksum="BDEAE9EDD1CFFAD9" modified="2024-05-29" version="1">MQGTTRKGTGHELRYELHVEYQPEPDQFEANQGMGLHLLAGPGRDRREAVLQTAVSRAELAPGVGFAAGHLLPAGGGVRATDVEEDETVSHADSSSTLLVRCTGVTTLGYFELGNRYNSGQHGPLFSARSDPSDLSTIDGFIRDTKMTEVGGSLYRDYDLINAIDEASLGNEYCYSEKAKEQQVPKSPGPLLLSLHALFGNGSVFHLAQDLAPLEATNSSSSAPEETLYQLLCQARPFPFRRTSEEMARRCSYYTKYYAGTLWTSEKLHHLLLLLILGDWFDIDFSGYDSGTSYLEMAMHLASQTLMEAATYPGYHFDAFRTDEVDRIWSLEGEEMIRFMVSDTAMIVLSVLVWRCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJR5</accession>
    <name>A0AAE0MJR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_479682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676911.1">
        <property type="nucleotide sequence ID" value="XM_062827543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJR5"/>
    <dbReference type="GeneID" id="87864697"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="497" mass="54717" checksum="8FDBD997E595F808" modified="2024-05-29" version="1">MTNIPQPIRPLGPIEVYSSSRHALGFYRCLANTCRYAVSWSVLQGKSVPDVLEAAVANLVLRLPRLSVAITGDEASGPYFASVSSLDLSHHLECVELPAELDSHARDSHLLHMLEAQHNQLWPDVGTRPPWRVLAVYDPRPSQLEDRLIIDIVLAIHHSLADGRSTAIFQASLLDELNKQPARPSCLEDHVLRMPSKPHGHILPPQEELVKFTTSWRFLAGTLLNQLASGWLGKPATDLPWTGAPIRPDPYQTRLRLVTIPAKAVSQLLANCRANGTTLTPLLHMLILTSLARRLPAETATSFQSCTPIDLRPFVQSGSLVTDRAESFGVLVTSASHSFDSSRVSGLREQASGEKIWSLAQTLRQELKDRVETIPQDDMVSMLRWVANWRGFWLNKVNKRREQTWEVSNIGSLQGSPEDTEPVSGSKWQILRSVMSQCAIVAGPALCASVSGVIGGPISIALSWQEGILESELVEGVAHDLQLWMDQGGPVHGQKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MK81</accession>
    <name>A0AAE0MK81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_392392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676924.1">
        <property type="nucleotide sequence ID" value="XM_062823754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MK81"/>
    <dbReference type="GeneID" id="87860908"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="150" mass="16923" checksum="54D1B737E1305E19" modified="2024-05-29" version="1" fragment="single">ATVTVNNANITCVYWHPQDRQAEAAREYLPTLQLQHTLVVGDFNAHHPTWDPQFRHSGRGEALEETTATWGLNLLNTPGIPTHRHANGQSTLDLAFGVERSYMRVGAWVSDHRKLVITIPARRNIPPPKKYALPPTNAEDAYEALMRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MKY6</accession>
    <name>A0AAE0MKY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_338174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677105.1">
        <property type="nucleotide sequence ID" value="XM_062823599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MKY6"/>
    <dbReference type="GeneID" id="87860753"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="314" mass="34336" checksum="13DDF2C02E247695" modified="2024-05-29" version="1">MNATYSSNSDNESEDGWKLAIARNMDLGSRSEYEDDEDAYDVAIQLGKAGEKGSGYHTKNDPSAPYQRQTVIERRGIMEIRCRSLAVIHGGLQPGSDKQATLLVYDVSLDTVRKSRRITWVQIEFKFASSEGGRSPEVFSIAPAGRVGLLPSSQDESVRKLGSVTAGASELFGNVGATLEWEKTVSRTSSDSARVVGNTLCDDLGRQVGASWILEENKAIKSGVPSLLRCAMVVSRTNNGQFECDVTIRAKADWKTELGRLVALKTPGDDPILFDPDAAPTNRLSRESFYDVNNLASTDVNDLVDIRYQTLFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMX1</accession>
    <name>A0AAE0MMX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">POU-specific domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_479059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677927.1">
        <property type="nucleotide sequence ID" value="XM_062827514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMX1"/>
    <dbReference type="GeneID" id="87864668"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POU-specific" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="210" mass="22968" checksum="96277BB6A3B00A0C" modified="2024-05-29" version="1">MHTDCVGVAKKVRRLAKEEQCWRCEDETAWGIDKYCEPGQVQYPLVVPGTEAALQMLPEPGRNTAQRPNERTASDAVIIESSGSSRGEHSVQQANNLPPTSADPAPGTATAPASAATPDTALAPASGTASVENPASITTNANISDRDSAKLVRDRGRLAKESAEIRKRAKREYKKLNKKHKKELKKLRKKSKRELESVTNRYKHRSISLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN81</accession>
    <name>A0AAE0MN81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar import and degradation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_306535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677329.1">
        <property type="nucleotide sequence ID" value="XM_062823224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN81"/>
    <dbReference type="GeneID" id="87860378"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3337878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="400" mass="44900" checksum="C48548EBABBBEAFB" modified="2024-05-29" version="1">MPRASPSNDAIDPLSPRPYPFSSCPDPDDSQMHSQPHHQYSSPSMIPAITAPSTADDTERPGPAVMSPESQSEVNRNVDIDHGPERMRDARRDADEAHKQRTETDDETPGTASDSAHAVHVEQANRTITANRVPAITANRVPTITSNIRPLRTHGVIGGHRSRKQGDELVAPSATTLGQVEEVDLTGNDAPWVHDYGLAGLSYEYCQTRLIPSTPSSYLRPGSKFSGMQKSERSRYDVEVEIKQVDLRESFLCGYLRIQGLTDTHPTLTTYFEGEIIGPHYSFLTQHPQWGANDKIDISHWNKFVAFKPYAKTAKRGGVQIKDVAQKDNIFMRWKEQFLVPNHRVKTINGASFEGFYYICFNQVLGTIQGIYFHSKSEKFQQLELKHVQDKGCFGAMEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNK9</accession>
    <name>A0AAE0MNK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_282620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678171.1">
        <property type="nucleotide sequence ID" value="XM_062822900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNK9"/>
    <dbReference type="GeneID" id="87860054"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="460" mass="48915" checksum="6CB2B7E7C0B47B63" modified="2024-05-29" version="1">MIVPVLSRQALRHASVARVALPSLTRWYASYPPHTVIKMPALSPTMTAGNIGAWQKKPGDKIEPGEVLVEIETDKAQMDFEFQEEGVLAKILKESGEKDVAVNQPIAILVEEGTDVNAFKDFTLKDAGGETSSAVPKDEPKDESTASAPTPAPTPAPEPENTGFSGRFQTALEREPNALPAAKRLAREKGIDLRTVKGSGPGGKITEEDVKKAIASAPAAGAAAAPAAYTDVPISGMRKTIAARLKESVSENPHFFVSTNLSVSKLLKLRQALNSSAEGRYKLSVNDFLIKAMGVASKRVPTVNSSWRDGVIRQFETVDVSVAVATPNGLITPIVKGVEGKGLESISAAVKELAKKARDNKLKPEEYQGGSISISNMGMNPAVQHFTAIINPPQAAILAVGATQKVAVPVENEDGTTGVAWDDQIVVTASFDHKVVDGAVGAEWIRELKKVIENPLELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP70</accession>
    <name>A0AAE0MP70_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H65DRAFT_476590</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678816.1">
        <property type="nucleotide sequence ID" value="XM_062827374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP70"/>
    <dbReference type="GeneID" id="87864528"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF74">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="138"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="287"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3339456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="396" mass="45073" checksum="49C7361DEC3AEF94" modified="2024-05-29" version="1">MPPKIESQEIETYWNIFSARTNGGKFLTGEQAAPVLKNSGLRDDQLERVWDLADVDNDGNLDFEEFCVAMRVIFDLLNGEYADVPTTLPDWLVPESKAHLVQANRALTGKAPKFEQVEDEDDTPGLKDGFDWYMSPADKSKYEQIYQENRDMRGEVSFAALQDLYDSLSVPDTDIRSAWNLINPSASSTINKDACLAFLHILNYRHEGFRIPRTVPASLRASFERNKISYNVNDPSQSRWAQKADDETSTGRKAKFGDQYLTRLGRSSFKTAGTDFSSEQKDDQWEEVRLKKQLAELEEKMAKVEEAANRRRGGKRDTKPALVKRELEQLLDYKRKELRDLEEGKGKAAAGGSLKSVADDLATVKEQVEGLEAHLRSRQEVLEQLRREIEEEKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPB6</accession>
    <name>A0AAE0MPB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B0H65DRAFT_292001</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678529.1">
        <property type="nucleotide sequence ID" value="XM_062823024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPB6"/>
    <dbReference type="GeneID" id="87860178"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="134"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK3339169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="231" mass="24914" checksum="4D4F14A909931708" modified="2024-05-29" version="1">MAPVSIVSRAAMRAAASPARAVRALTTSTSLQGVSSSTFESPFKGESKAAKVPDFGKYMSKAPPSTNMLFSYFMVGTMGAITAAGAKSTIQEFLKNMSASADVLAMAKVEVDLNAIPEGKNVIIKWRGKPIFIRHRTQAEIEEANKVNVSILRDPQPDSERVKKPEWLVMIGVCTHLGCVPIGEAGDYGGWFCPCHGSHYDISGRIRKGPAPLNLEIPNYEFPEEGKLVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPC5</accession>
    <name>A0AAE0MPC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase III subunit RPC82-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_582587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677945.1">
        <property type="nucleotide sequence ID" value="XM_062830859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPC5"/>
    <dbReference type="GeneID" id="87868013"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="219" mass="24695" checksum="F278772EB1241B00" modified="2024-05-29" version="1">MAPGLLEEDLDPALDPRQVIRINYEKCTVELRSRRLVQYVNETLGETTGYVYGQLLAENENKSGHHGRHHPGQPPGQPPSTRLTGTCYEYDGCMTFDSVPWVVTMKKNEHYFPTTELIKDPSEPLTGWRRITYEGGKKIEGEGHEGSEAEYKLALSFWIALRMRTWGAIAERSDDARKGQPRSASLNTTITPIAERQELFTSVPSAPSARHACWRCCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPM7</accession>
    <name>A0AAE0MPM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_254606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679251.1">
        <property type="nucleotide sequence ID" value="XM_062822536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPM7"/>
    <dbReference type="GeneID" id="87859690"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="663" mass="73932" checksum="1F7B0C04AAC96D70" modified="2024-05-29" version="1">MDFCLRNKFQSGVLLAGRYQTISPLNHGSFGMVFMARDLKTGQKVAIKCLTKKGAASEAGFDFAVDEKSEELVLHRRLGAHPNIVNFIDTFETEAHTYIVLEYCERGDLYEAIRLDQGPLETEHVRRFMLELVDAVAHIHAKGIYHRDIKPENIFLTQTGSAKLGDFGLATTEKWSYEAAVGSERYMSPEQFDSAGAGYSPAAADIWAIGICLLNVLYARNPFTQPTEADPLFLDFSRDKQSLFDVFPSMSQDTYEVIVQCMNLDPRKRSLEGAREALLRVISFTTDDEILDEFCTADGPVVASSNREPLRTPSIQSPQMDTGAFPWAKALHAKPQRQLSDIPDDESYTEDLFSTSTATTSDWLSASIQTPPSVSSVMDSHLAASMQSLNMGSVAQPSKDMFAKIPVRPSVAAGSLPINMAKQPKQSALSLVFGRKDTVSKSWSDLWDEEEEEEEEQAKQLSLKEMNSRTWSQESKHDDENTPRMGLSPATKAGSLHMEHDIPAIDMHLGSNIDDDLAADGFFFHDAPARKEPTQFPMSHSPPARKSALDRWQALGERRRATGTTPPKGSESIPRTRQIPHSFGAASHDFNNTHHNSYTIHSNNHSSHHYAANIGKKSTPVKQCPWSKGRDRAFDWRKEKRHPFDVEWVGGWTGAPLVPVHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQL3</accession>
    <name>A0AAE0MQL3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_527179</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680672.1">
        <property type="nucleotide sequence ID" value="XM_062828870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQL3"/>
    <dbReference type="GeneID" id="87866024"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042296596" description="Endoplasmic reticulum chaperone BiP" evidence="15">
        <location>
            <begin position="33"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3342879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="663" mass="72514" checksum="3903574EF2590659" modified="2024-05-29" version="1">MEHRTRSWALGLSILGFFALLFSAGFVQQAHADDTEAMGTVIGIDLGTTYSCVGVMQKGKVEILVNDQGNRITPSYVAFTDEERLVGDAAKNQAASNPHRTIFDIKRLIGRKFSDKDVQQDIKHFPYKVVSQNDKPVVKVEVKGVEKTFSPEEISAMILGKMKETAEAYLGKKVTHAVVTVPAYFNDNQRQATKDAGMIAGLNVLRIVNEPTAAAIAYGLDKTGEERQIIVYDLGGGTFDVSLLSIEQGVFEVLSTAGDTHLGGEDFDQRIINHFAKLFNKKHGVDVTKDAKAMGKLKREAEKAKRTLSSQMSTRIEIEAFYDGKDFSETLTRAKFEELNNDLFKKTLKPVEQVLKDAKVSKSEVDDIVLVGGSTRIPKVQALIEEFFNGKKASKGINPDEAVAFGAAVQAGVLSGEEGTEDIVLMDVNPLTLGIETTGGVMTKLIPRNTPIPTRKSQIFSTAADNQPVVLIQVYEGERSMTEKNNLLGKFELTGIPPAPRGVPQIEVSFELDANGILKVSAHDKGTGKAESITITNDKGRLTQEEIDRMVAEAEKYAEEDKATRERIEARNGLENYAFSLKNQVNDEDGLGGKIDEEDKETILDAVKEAQDWLEENAATASAEDFEEQKEKLSNIAYPITSKLYSQGGPGGADDEPAGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRA6</accession>
    <name>A0AAE0MRA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_576433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680644.1">
        <property type="nucleotide sequence ID" value="XM_062830660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRA6"/>
    <dbReference type="GeneID" id="87867814"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF63">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="272"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="830" mass="93402" checksum="938AB368168B4B30" modified="2024-05-29" version="1">MSTSRRAPPPPISRTSTSTNSRMASQYTPPSYSSSQAYNHSPLSQSHHSPSEGGQSPKPSNHNESHAYSHHHHHHSRFSIVPIIPSSSLSTKSLNLRDNLRRDMRDMNGITNLKKYRQRRRLFKLASILFFSCLTLWSLFHYFFFHHGGSSTVSPFFYSFSSGSSKKEGGGNFNPSDLGEEEEVVDYEAIASSSRTKSSSPRGGGSVRRKLTDEILLNNLSLDGETCRATFPGLMKEIDDTVAKGPFKVKRSSDLGPMQRKRDLSREMVNFDTILTLNILDTPFGTALQYTRNADPVHAPSDRDARTFLIPHFSFWAWDLPFIGSISRAASAITQLEETQFQEGNRWHSHKDPRAVWRGTTWFNSIHNPQLRYKLVSTAKNKPWADVQSLEWTGGGGDNKNATNALAIEDFCKYKYVLHTEGISYSGRFQFLQMCASVTLTPPIQWMQHTTHLVKPLFSSDLDLDKARSLRMRKNGKTKDTRAKKPGAAAKDGVVPWTPHVRHERAWPKRYDPNEANIVFVSPDWSDLEDTIHWLEEHPKVAEGIARRQRELFVGGGPAAEACYWRELVRGWAKMARPEKGEFEELGHYTQVPLQDFSIRVTPSKNRHARSPVLPYPPHILCKLLARDSLSACPRKRRMLVRIEERVLQQLDVRRLHRLEDLSPMSAYVSVLLSPLLAPYPTPRGSTHNFHLPLPQSNTTSRSRRATLPQNPQPSTTLLSPYPMPTRPSSSPTSPINPSSPHIHNRNKLGPRIRLEPVRRQAVVHRMQQAKVTGQAHAGRGVAARAQLEDVKSRREQEVELEGGAGRSVGVGGGVVGGEDLDVEGVVLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRM1</accession>
    <name>A0AAE0MRM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_242307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680974.1">
        <property type="nucleotide sequence ID" value="XM_062822341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRM1"/>
    <dbReference type="GeneID" id="87859495"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041938211" evidence="1">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="112" mass="11776" checksum="A176DCA77EDC9EAC" modified="2024-05-29" version="1">MKFSLSIVLAAFALQSTALLVPRDALSSNLGSGLAPGAANILPLEVRAGKDKGKHSHAHGVRPDFRKPCKSLPSNCPPFLNQKAMCECKAAATVASYLESERGCPKPSQKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRQ8</accession>
    <name>A0AAE0MRQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_524189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681471.1">
        <property type="nucleotide sequence ID" value="XM_062828817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRQ8"/>
    <dbReference type="GeneID" id="87865971"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ima1 N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3344858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRT9</accession>
    <name>A0AAE0MRT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_227399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680510.1">
        <property type="nucleotide sequence ID" value="XM_062822142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRT9"/>
    <dbReference type="GeneID" id="87859296"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="293" mass="32290" checksum="7452F1034D3D0D1E" modified="2024-05-29" version="1">MITAPSIPALSGPTISGNVVGLGGAGIVSGWIRDGMVAGRDNDIYWTGQTTRDNVSGHYTTAAITTPMVGHASVAGEADAEPVADGELGGMIPLLSTPSSFLRLGIPTLSARGSLLLGFLQLLWQAIVTWSIRHRIRAIVWLVAKAPFIILGDLWINLYACVNYDPFANRGSSHASPTGGLTKFQILFWDWTKWLRCDAKLWLLSVWEDLRGFFARGTSFFSRNTKKKRKKWRIPGPTLQGIVADTKSQLEREEEEKELERRRKEQETAADNGNGGSRRKGGRGNGGRKQRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSA4</accession>
    <name>A0AAE0MSA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_146224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682397.1">
        <property type="nucleotide sequence ID" value="XM_062821009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSA4"/>
    <dbReference type="GeneID" id="87858163"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="158"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="485"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="595"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="802"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="687"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="864" mass="96020" checksum="2F8B65668DF38E23" modified="2024-05-29" version="1">MVKTIQLGSRLRYPITITKLYKEPSQPIKKKEALFQYSFKWTRTVGDTIRGETWEKEETTYADWSSPSDGELKSWKIRVGQEILRDQDCMVVKESCSHDVQFGGLCAICGKDMTEVNWAAESRDMDRAPINMVHDQTHLTVSETQAQKTENALQRRLLQHRKLSLVVDLDQTIIHACIDPTVGEWQKDPSNPNYPSVRNVKSFQLDDGPRGVANNCWYYIKMRPGLEDFLKKISTMYELHVYTMGTRAYAQNVARIVDPDKKLFGNRVISRDENGNMYAKSLQRLFPVSTKMVVIIDDRADVWPRNRPNLIKVSPYDFFKGIGDINSGFLPKQQGLLTPSAATTNGGLARIAPAPSPDKEDSTTEEPPLEKALEEQEKTLEKQIKDRPLQALQEQQDKQDEEAERASATPENGNTESTTPPPPYHRHQVLQDDDRELAFLEDHLTALHKSFFQAYEQNRLSQPSSSPSSLDTQSIPDVGSILTTLKSQALSGCKIVLSGIVPIGMDVYRSEIGLQVASFGAELRSSVTRDVTHLVVSSQRPRTKKVRQAIRFLPKIKIVNQDWLAACFSEWRVVEEGPYLIEGLEDAQKKLNEKVQDAEATETVSDADDTDTPPGKKRILRLKSPPRVRFATAATNEDEDEDDSDSGGDDEDEDEDMDEELEALKPVDEDGQLSPIDGLKTFNWGSADEELAEFLESGSDDDDEEEDGKDDDDGEDNDNADDDGDVQATANTSTTTSSYEQVLAAPTKRKADDEEEEESNKRRKSLVGPGPSLLRNELKDEDVEATSAAVAEAAEAAAAAAAEVEAQAAQDAQDADDLDKEFEELDEEALEADFLAMDDGDGDEVQGQQVNGDGNGNGGVSENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSH0</accession>
    <name>A0AAE0MSH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_570347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830446.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87867600"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3347495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="149" mass="16813" checksum="13BF80A31BB00B7D" modified="2024-05-29" version="1">MIRVYRPPLGTTLQKKTEKALAGAKKRTGDARNAIAKTADRRRAMVMAQAPQRPAFGASMEEHRYWRDSQRLRLVQGDAGTLSVPTTSWNHTPEQVCRQDNRSPRDDTLQYSSQSTDIDGVLKVEKDTDFGKRGGTTKHKTPTMKMDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MSQ0_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">DUF2407 C-terminal domain-containing protein</fullName>
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        <name evidence="5" type="ORF">B0H65DRAFT_464739</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681470.1">
        <property type="nucleotide sequence ID" value="XM_062826769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSQ0"/>
    <dbReference type="GeneID" id="87863923"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like" evidence="3">
        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 C-terminal" evidence="4">
        <location>
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            <end position="365"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3344857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MSU5_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062828179.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87865333"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="307" mass="34563" checksum="101EA79E92D9718A" modified="2024-05-29" version="1">MGSISYFTDSPPSPPSTEHVLAALDNVQTRGYHCRALLLPWPHSLCAAILEPALIRTLLPDFSFLASFQLGPASAASSPIDRQHNVYDLSDDHDDVDPRDPDPYSDPRPLHLHHPSNPNRSFALQQLSQLTEDNIMFLYPEGRDGPTYLLRSGPNARLVRAPEEHYADGDGDNDDNDGEAYTAAHRLRLYHRFPTQTPEDAVRQMITHHEEERLEITFEELIRGQDWGSHPYPLLVPGVCFRIPDPADRRRVDVMTVQRNRLLRSSGSGLSSEATGMVLGIAIHQVLADATGVDIIMSRLRREIWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT03</accession>
    <name>A0AAE0MT03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_196203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681755.1">
        <property type="nucleotide sequence ID" value="XM_062821719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT03"/>
    <dbReference type="GeneID" id="87858873"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="101" mass="11170" checksum="7495C96E50AB9E72" modified="2024-05-29" version="1">MSSYTLLSVGTVISPRTILTALQLLVTCLAIYATTYARVTFEGQRLHSQDVGKGVVIFFYAFLPSCIFSTSLHTAPLLDSFDSFTSISLAEMVSSRFFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT23</accession>
    <name>A0AAE0MT23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_507505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682474.1">
        <property type="nucleotide sequence ID" value="XM_062828141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT23"/>
    <dbReference type="GeneID" id="87865295"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="523" mass="58094" checksum="46D1ABAA1F5EF4DC" modified="2024-05-29" version="1">MAAQSDFITACETGDVEAVTRILEKEVVSDDLDQLQKGLSRAAWRSHPAVANILLSKGAKVDRTSFVGSTNRGDPTMFELFVKYGFDINSTEFGEGTALRMSVGNENLTRWLLAHGADPNVAHDRAPSPLISAAITEKGGNAVRMLLEHGAVLEPNILHYAVQSRASMSDRRDRVEQLVRAGANINHIDPKRKGTPLHCAVWHNRGDVVEALIELGADPNVVFQGRTAADVAKDRCQKLEHYLKIYQFLKDKIKVTPEDPNQGQGTCSACRPPVVFTTAGSLAARGYYTHTQAQAHNASALYLAERTITEPTPGKEDAFMVTEIEEATQMVWEVSEGSDVNTACFTRLDGKNAVSIGTSHLCGCTVIVTISQRGRRLRRALLGEHLVFVSDDLFRQTSTETNDQLFERTVIAPIQRGKSLRTRRARLGNQESDNIRAFQVRPDKPYRKQMMNDYDLSQNYQEWARIKSTVGGIISLLNPDTEAGSSRWQDVIYGRRSNNTNGRVLIKYAADHEGKKKWAETDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTC6</accession>
    <name>A0AAE0MTC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_466829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682100.1">
        <property type="nucleotide sequence ID" value="XM_062826879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTC6"/>
    <dbReference type="GeneID" id="87864033"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="73" mass="8267" checksum="037CC8E4AE5DCBE9" modified="2024-05-29" version="1">MLVIRSLSQVVLTPMQLVQPTSCLSRQRNHPISASVCMTTTADDSSGTVWITERAFQMPIYHGRRRRTSSNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTN1</accession>
    <name>A0AAE0MTN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_439582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683852.1">
        <property type="nucleotide sequence ID" value="XM_062825424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTN1"/>
    <dbReference type="GeneID" id="87862578"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3350557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13832" checksum="200487436E78B8D9" modified="2024-05-29" version="1">MAWASKGQVYTSFAKRAAGSVGAQPSKQSDNSIDCFRKVIRNEGFKGLYSTWLPVVAATQYTSGGRDSSSAKNVRDITGSLNAVLWTSFVMMAYIYIDAARREATSCGNLTFTVGIPLRQRRGMCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTQ5</accession>
    <name>A0AAE0MTQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_460331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682460.1">
        <property type="nucleotide sequence ID" value="XM_062826523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTQ5"/>
    <dbReference type="GeneID" id="87863677"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="187"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="866"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="918"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="951"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1137"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1187" mass="128265" checksum="6BDBD33D160D2F52" modified="2024-05-29" version="1">MPGLVTATGVLAFLADEEPELKVFALKTLNDDIDTVWTEVAGALTQIEALYEDETFPERQLAALVLAKVYFHLQAYNESMTFALAAGPLFKLDAPSEFEETIISKCIDQYIAVSSLHHTPSKKDLPPLLTDLGSGAIDSSALISPTTPFSQSSVPSKSLLARASSDDNTILDPTFQPTKETRSASIAQVHDTATQVALQNVIERLFENCLKEGKYRQVVGIAVEAKNLDVLRRVIKRANEDVKSGKTKVQEGSQGPAEELMDYALGICMDIVQERGFRTEILRLILDLLNDIPNPDYFAIAKCVVYLDSDEEASRMLRQLVTKGEQDSIAIAYQIAFDLYDNGTQEFLGKVTKALPSGEPPKPKPAEESSDAAAEREPLLEGQESSEEELPEEVAKVYKNIRTILDGSKAIKLNLEFLYRNNHADMSILNKVRDSLDGRNSIFHSAVTFCNAFMNAGTTNDRFFRDNLEWLGRAVNWSKFTATAALGVLHKGNVTQSRKLLEPYLPRPSGVSTGSVYSQAGALYAYGLIHANHGADALPYLHQQFKDADQEVIQHGGALGLGIAGMGTGDQKIIEDLKEALYSDSALNGEAVGAAMGLIMLGTGHAATIDAMFTYAHETQHEKIVRGIALGIALIMFGQQESADRTIQLLLANPDPILRYGGVLTLALAYCGTGSNKAIRKLLHLAVSDVNDDVRRVAVMSLGFILFRKPGSVPRMVELLAESYNPHVRYGSAMALGIACAGTGLDEAIDLLEPMMKDPTDFVRQGALIALSMILVQQNEVMNPKVAAIRKTLKKVVSDRHEEQMTKFGASLALGIIDAGGRNCTIGLQTQTGNLNMAGIVGMAVFTQYWYWFPFTHFLSLSFVPTSIIALDSDLAIPNVKFYCATRPSLFDYPPEQEVKVEEGPALVTTAVLSTTAQAKRRAQKKEKAQRRESMDIDTPAVSKTASQPAAEDKMDIDDDKKAAAKPEESKEKKEGESGDKEATAATDAKKKAEKEKVGYEIENMSRILPAQLKYISFPAGRYKPVKKPTGGPLLLFDTQPSEPKVLLEEKLNKVTTERAPVAGAGASGSSDGTPRLSGGAAQSLLSQLQGTGAFNRSSMRELSELLQLGQRMEQDAAAAERGERRARGSGNAAAGTGSGAAAGSGAGAAAAAAVLNAVDEDGESDEEAPTPAEFDYFTDAEADDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU23</accession>
    <name>A0AAE0MU23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_90458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683811.1">
        <property type="nucleotide sequence ID" value="XM_062831549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU23"/>
    <dbReference type="GeneID" id="87868703"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="879"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="945"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="728"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="984" mass="105936" checksum="0BDA2B5CB5E529F7" modified="2024-05-29" version="1">MIQFGPRFSSLLATDPASRLRRAGSDPANARREDTSRLQQLTACEINLSTDMPGWRYAFALSKDAVKAATPPGTVRLIEHKKRPLKDHDRPPQDTRSTPSPELDLAKFPIPTSDPSDPLNWARWRKLSCLCTLCNYAFVCSFASASLAPALAIWNASFPYDPRGMGDLSRFTALNVLLLGLGNIVFVPLANVFGKRIVLVLSALTLFIATVCGTRDFGLGMYENVLVIRIFQGLGSSVSETVGPAVVGDMFFVQERGGWMALYTACLASGSVIGGISGGYIATRYGWFGIFWVTAVLAGVAFLAMVFLVPETLFERGPLCFPTIATDTPKGRSQRHRHRNHDDIAEEEKEIEGGGNDDRNRRSSVRRYYYQPTPTPYLSLGTLPSIRMTMPSRFITSVYTPLNINTNQPQYFRDYWDPRLGLTWYETASESDESEERFSMAPHGRESSMPPTVLRPPPTAAQGGREAAAGGLPPPPTRGGIAARRATARGGPRYRLYPPSDIDTHPIGGRGGNQNRPILRNPEGNANGRLSNRFPSLGPFAPLNRDSEAFSIPSSDPSTHYEPYTYLRSLRFFPRQRPHPPPNPFDPAALNPFPDPSPYSPYSPNFNFPKPSFSKANDPSSPRHRHNLARFPFPAKKKSLFQHFISPLLTLRLPSVWVATLQCSALVGSAAVMSTLGASLLASPPYNWTVSHSGLLLFSGALIGIILGGLYASVLADERTKVKAVAGAGAGTGTTKRASNNKRTRGGGEIHGLGSGGSRSRRGGRRTAGGGGGKKTERVKSWGERLFGGTGGNSVYGYAEAESRLVVALPGLVIATGGLLVWGFCGEYGPALNAAAAAAAAAAAAGNSTVPGNVTAPAVGPGLSSGNGGGGYGVNRYSWLGLVFGFGMVSFGVAGVPGVWFNYLIDSYANLASDCFVMICISRGLIPFAWTFFISEWVAKQGYLIPFGGGLTVILGVFSLLLIPVIWYGKRMRIATARFVVGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU66</accession>
    <name>A0AAE0MU66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_546212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684452.1">
        <property type="nucleotide sequence ID" value="XM_062829434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU66"/>
    <dbReference type="GeneID" id="87866588"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="137" mass="15977" checksum="73ED9519F0A2C1C6" modified="2024-05-29" version="1">MSIHMKGRCVCKNLQYSLELESLDDARTTLCHCNSCRRAFGTNYGLTTKVPLQDFKYETGTPKKFKQHNGVTREFCDNCGAYICEYGEEAADKFRYIMWGSFDEPEKVPPKGEFFCKNKPKWMPDISDTFRKQEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUE5</accession>
    <name>A0AAE0MUE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Questionable protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_101664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="87857600"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MUQ6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_133247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685053.1">
        <property type="nucleotide sequence ID" value="XM_062820838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUQ6"/>
    <dbReference type="GeneID" id="87857992"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="220" mass="24955" checksum="4D20B5F8DD51FC23" modified="2024-05-29" version="1">MSPFRPPFLQTIPRQSRDHKPSYRVVNTPDQPFKPTTHFKHRLLLASCFRPLSSFKPCRFSIWLMGDPAFPSLGLIRSHFTGNQKKQQEKTRRNVRFVMIHCSHSGLCSGALSQLAIIQTWPGYLIIFPGSLHQSCCVLHSNKDCYQKNHEVGTDDTENHAYFEPSVLLQRKIGTESSSLPFRGLRRVLPARLHSASGTGRRIEGTTIHQGTGSPSTQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MVC2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">B0H65DRAFT_420081</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684170.1">
        <property type="nucleotide sequence ID" value="XM_062824254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVC2"/>
    <dbReference type="GeneID" id="87861408"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="358"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="154"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="151"/>
        </location>
    </feature>
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            <begin position="196"/>
            <end position="206"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="527" mass="57907" checksum="181B2A1DBE4F96AD" modified="2024-05-29" version="1">MNYNSQDQWSAGWAHTSSGWSNTPNEHHTGQQVDGVEDLIDEFGATSIGHQQVYDQNSAYHTQAYQLPAYQNLQQQPYPNTLYQPQLFPNQQYQATLFPSPGYPTSAYSNPALHEQYVSQAGFSQTYSAGNYTHRSQPSYSGGETTPSLPTFNLFLPNASADQLQIHAGPASQDRTPTFIDKGKPPEPGTKSKNRGPGDRHRDRGNGKGKTNNRGYSSKLGKTSAEPDDDEPFFETGEDSRTKTDGYSQTSSCLNRDGGQHPESTDQVTSPSAESVAGSNGLSFGNGFNADALSPDYSSATAYEDPISQQTMLRMNLSPRAGYPLPLGLSSGAIDYSVSTNRSISGPLDPRYKVHPSSKFSPGSVFKILWPEPAGVNLNELSGEIERDLVQDPGHLFYSSIRRFIVIGNDEGNCTCVKAGVKPRQHGIAYHAGNQPQLLEGEPQLGFEPIQVEMLDSPHETLVMESRVNYSKLMTIEHNYKVLFIGRVAHEDFKDIVIPAVDACWNAKNRGTTSDHHRHISRGSVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVQ1</accession>
    <name>A0AAE0MVQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_415215</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823973.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87861127"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="APQ12"/>
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        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
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            <end position="64"/>
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            <end position="124"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Mid2 domain-containing protein</fullName>
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        <lineage>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685474.1">
        <property type="nucleotide sequence ID" value="XM_062829225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVV5"/>
    <dbReference type="GeneID" id="87866379"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="27"/>
        </location>
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            <begin position="28"/>
            <end position="368"/>
        </location>
    </feature>
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        <location>
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            <end position="192"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="355"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3354096.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="37987" checksum="3117F65535BE6C3E" modified="2024-05-29" version="1">MASRKSPLSLFSALLLACATLPQYAAAAPYPQPEPQANVVWYTSVWTDTLTQTHTSVWSTVVGAMATNGPDCVPNTSLGESACGSICCAASQKCQYAGQCMERGPNDGAPFLGSTLAGHTYTTQYSAPYRPTSGATGTAASATASSTGGAAGGAAGGGTADTGLSGGAIAGIVIGTLAGVVLLLLLCACCIVRGLWHGFLAIFGIGAGNKRTRETVVEEERYARHSGRRDSHGSWYEGAAGGRPSGAAARKESSGKGLMGAGAALGTLWLLLGMKKDKKKESSRRKSRSENSSYYYSDYTSSGSPSSFSSDRRTRRSARSASAHGAGRTRTASRVTRTTTRVSRVSSVPPPPPGQRRIPSRSPGPMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MW07_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825882.1"/>
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    <dbReference type="GeneID" id="87863036"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="357" mass="37978" checksum="82AC67B4A14352AA" modified="2024-05-29" version="1">MASIGPQLPPHLQKRKRDDEDEESSSPPTKISRPDNRDEIPLEGDDSGDDFGPSAPNPNPSHISSSIGPSAPPRPSIGPTAPTSSASAPKRIYGPAPPPADLSERPTTDPNSDSDSDSDDGYGPALPGTRPAAAANSSNRGPSFPSFQQQQQHQAEEPQAPKRDDWMVAPPTNSSYRAPDPTKLKSRKFASGRSAATGEKSGGGVSSIWTETPEEKIKRLAAAVLGREDPSSSSHSSATAASASVSKTSRPKNLDEERVRSYTEQTRGRSLVEEHQAAIAAGKKKLTSASSSSASKSGRPGDKYGKQDVDDEDDPSKRAFDREKDMAVGGRISHTQRKDLLNRAANFGDRFQSGKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW37</accession>
    <name>A0AAE0MW37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_36645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686492.1">
        <property type="nucleotide sequence ID" value="XM_062823682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW37"/>
    <dbReference type="GeneID" id="87860836"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="57"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="557"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="722"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="876" mass="96549" checksum="1FA77B07BF6B8ADB" modified="2024-05-29" version="1">MAGFFNKLKGAGAGSSKTDNNASSKNKKDEPAVELTPLERILQNAGPLREDGSDKYFGLENFGNTCYCNSILQALYYSEPFRENVVNYPPLDNTSEGKTSKVKVSIRPPVQVNGNAAAPGKQFPKPRQGFTPGPIPMPITQPIRPEDRPEAPEYKKKQAMIKGPVLELAQENPDAYGMEECTFTGLKDIFTALIQSNSRTGVISPQRFLDIFKRDNEMFRNSMHQDAHEFYGLVLNDVISNVEAYARRMQESGKENGTIQSPLNQLSSSPSLMRSMMASNFRMPETSWVHDIFEGVLVSETRCLTCETASQRDETFLDLSIDLEEHSSVTSCLRKFSAEEMLCERNKFHCDHCGGLQEAEKRMKIKKLPKVLALHLKRFKYTEDYSRLQKLFHRVAYPYYLRMFNTTDDAEDPDRIYELYAVIVHIGGNAYHGHYVSIIKTKDRGWLLFDDEMVEPVDKNFVANFFGDKPGMACAYVLFYQEVTFEKMREELDAEGLEEMRLATQAADLAAGVEQVNGTEKNPLTKINSQPTVPVEDLDPSVSLAHAQTAPGGIASILQSSTPTQAPGPEPFSHPLAAAPPPAPAVMTKADEAATVPPKSKEELAKEKKEQKAQEKAQEKARKTAEKEAARLAEKERLEKLAKKREAQQKEQEQLAKVMRESKQLAAEEEKRRKKEAAAAEAGPKSVPSSPRLFNRAGLGSKSLSRKSFSFLGKTGGGGGSDKSEKSSDKDKSDRAGSSSTEQRSNGSMTSSGVAESNASSRATTGDGYGGGHNFGGFSPSSPLSPTSRGPTSSPLSPTSRGPNGIHPHNHYLPSSPMRSMTTTEGIKRDVRASRSASTSSIPGPPPTPPERFEKPPLRDRFSFSIGRKKSSRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWB4</accession>
    <name>A0AAE0MWB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_438573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686702.1">
        <property type="nucleotide sequence ID" value="XM_062825377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWB4"/>
    <dbReference type="GeneID" id="87862531"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="117" mass="13270" checksum="6964B3BFAB6B0B22" modified="2024-05-29" version="1">MELIRTFNCDLVWRLYISLLADDAVFITLDGVNEVGLARLIRILSSAKRSIAVFYFYLVLLIQIIINILESFKELGLLGIWAGSYCFGGRSIIGYKRRRKEGVRGGLAIWARALVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0Z4</accession>
    <name>A0AAE0J0Z4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_78104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676846.1">
        <property type="nucleotide sequence ID" value="XM_062831410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0Z4"/>
    <dbReference type="GeneID" id="87868564"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="75"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="506" mass="58779" checksum="38FEEE5A13800779" modified="2024-05-29" version="1">MPSDLDHDLLGTSLDPEKWHDNRNSCSFPLLRKPIIAIMTALTIPSSMASSLVNRLTNLFAMPNFDAPEKLRPTAYLDGLRGFAAFLVYWHHHELWSHGLMRDAIFERGYGFDGQHYFSALPFVRNFFGGGHYAVATFFVISGYVLSVKPMRLIHAGEQEKLADNLASALFRRWLRLFMPLIATTFLFMTSWHAFGIWVDSAKPQSNYHDEFWWWYAEVKNFSFIYHLGGEPWLSYNFHLWSIPVEFKGSMVIYTSLLAFSRCTRKARLWCQVFLIFYFVYIVDGTHYALFSAGMLLNDLDLLAIKDELPNFLTQLEPYSKHIFYSLFVVSFYLGGVPVHTKDINDLAKTPGWYYLSFLKPQAVYDYKWFYLFWAGVFLVVSVPRIPWLKRFFETRFCQYLGRISFALYLVHGPILWTIGDRLYTAVGWGREPQLTMLANWVNKFPLPMAGPFGLEMAFLLPHIILLPLTLYVAEISTRLFDEPSVTFPNWLYKQVLGSGQPTRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J134</accession>
    <name>A0AAE0J134_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_512642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677153.1">
        <property type="nucleotide sequence ID" value="XM_062828589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J134"/>
    <dbReference type="GeneID" id="87865743"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042222105" description="glucan endo-1,3-beta-D-glucosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 N-terminal" evidence="11">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="10">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="10">
        <location>
            <begin position="214"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3334987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="331" mass="35858" checksum="5B9500AB8FADB4E6" modified="2024-05-29" version="1">MASLIMALVALFAFATFVNSVAINSTLSFVSNSGLASRSHAGLFPRAHAGPPDSGVFDPHSVTPDSPDEPRMQTGSQDLCKDHDKEENGSHFCQNVQQVVYTNVNTPAGQYKAVTSMDKDTKRCDMAPKSFGGDLAPFNESISMHFHGPLHLKQFAFYLPGAGGSYERKGYYHAPSQTSEHLTFMGNFGGQGSGVFTEAWGASLSFANAHGDGGFPGTSRIFLFEFSMPQDAANPGYDEPAIWLLNARIPYTQHCWNFGCGEFDIFEIVNNAYTKALSTFHLNPFGAGDPNWFKRPVDGPVKVLLYMDPSEGGKVSVKMLGGSDGKLKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1C1</accession>
    <name>A0AAE0J1C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_330130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676903.1">
        <property type="nucleotide sequence ID" value="XM_062823502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1C1"/>
    <dbReference type="GeneID" id="87860656"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="261"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="474"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3334737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="61255" checksum="85C07374E57F5A86" modified="2024-05-29" version="1">MASPGNYHYSHSHPGGRSGSFLCLQEPQPPAPKGHSALAALIRNRPGVSLPNPLNPFARDDEEALAGLGAERRPVEDEPPRRDERRMSAVLNGPHMRSMRLIGNSNPRYRWERYWKIEDELATMKKPIREYYERCNYLVQQYLYIDKLLDSSLPHDLLNEYNDLPPWAFRGDLEAPATTPRPTNGATAEPAPTVSKARKVKRTPKDIYRPTETTPLFSDGSNAVDDDECDQVASQETRPEIPWLEDDDVDSSASIVTLAIYINFAANAILLAGKLAVVLTVPSVSVLASLVDAILDFLSTAIVWITTWLISRQDQYRYPIGRRRLEPIGVLVFSVIMITSFAQVALEAIQRLMSNDREVIQLGVPAIAIMLGTVVIKGMCWLWCRLIKNSSVQALAADASTDVIFNAGSIAFPLIGYYCQIWWLDALGGLLLSLVVIFNWSQTSGEHIRHLTGFSATADQRNILLYLTMRFAKTIKQIQGLQAYHSGDKLNVEVDIVLDASTSLKDSHDLAESLQYVIESVPIVDRAFVHVDYASYNLPTHMEQQHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J200</accession>
    <name>A0AAE0J200_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_436465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676897.1">
        <property type="nucleotide sequence ID" value="XM_062825244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J200"/>
    <dbReference type="GeneID" id="87862398"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="57" mass="6657" checksum="1A70B15D4611DDFF" modified="2024-05-29" version="1" fragment="single">KVVLYIIFLGIIVLLLESRRTIFSQFKIPLNISTLQVYKIKKGINLYSLLKYTTLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J256</accession>
    <name>A0AAE0J256_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_333432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676987.1">
        <property type="nucleotide sequence ID" value="XM_062823541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J256"/>
    <dbReference type="GeneID" id="87860695"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="580" mass="64073" checksum="054DAFD292EFCB41" modified="2024-05-29" version="1">MAVVITSEDDTFFGSPLRRSQSQPKFNTKRSGFHTSASTSRLSDIYHHSSKAFDHSTPSSSAPSSPRAIHLESSELSDSSTPVTNPSLTSDSDDEDILEAAISRRGFGGRLPRYEEDVGYFNHVEHAGPPPSPRTDQSYTSSPSGNDTSTPTSRPESPELVYERAEDDMAIKIQPSRHVDYLSHNWREEDIWSSWKLIVAKRGDYANSARLENASWRTWMKSKNNLGTVSPETLNWLKDCDVTWLYGPLQTGPSIDSNNSSNNSARMSKTNSFAKKPILKKRSMSELMLHRSLSASSLVKQAAAAVQAQQKGVLKKTGFRRPGLDRANTDFVTFPFSSRGLSNDNSLFPTAVSSGLVSPSGERKHIHFNEQVAQCIAVEIKGDDDDDDVEPEINYNSDSDDDAIMMKRTKGKKLRPVLKKTKSHSHSGGESRTIAMLPSTTLKYREDTPEPTESAMKHSTGVFRGTVLSPSSSQETLRPAKKSGRFFVDSDDEEDEDDEPTSNWSSAKSTEGSLGGLRRSTSSASLSKEPAGMRRTESGMFMPYEQGENSNSEGLLGRVIDTVNTARDIVHVIWNVGWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6N8</accession>
    <name>A0AAE0J6N8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_435477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677325.1">
        <property type="nucleotide sequence ID" value="XM_062825193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6N8"/>
    <dbReference type="GeneID" id="87862347"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001690">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="6">
        <location>
            <begin position="94"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="5">
        <location>
            <begin position="420"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="4">
        <location>
            <begin position="579"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="624"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3337874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="840" mass="95259" checksum="60D55B0A8FADDC86" modified="2024-05-29" version="1">MDEPLTDLRGPLAAKYTASTEYSKIADNFKVPYVSQDVQEVATMVNGLENGAKKKTSLKVKKTTYEVAKSRDHIRVDSWRFHDWDYKKHDLPTYARGLFTTRDKNGAPEITTRGYDKFFNVDEVTETKWENIRTRTQGPYELTLKENGCIIFVSGLADDTLLVCSKHSTGDRSDVETSHASAGERRLEEQLARIGKTKADLARELRRRNVTAVAELCDDSFEEHILAYGPDKAGLYLHGMNLNLPEFMTYPSPVVQKFAEDWGFIKTGLIVIDTIDEVKAFLEEVAESGAHDGRDVEGFVIRCKMSYNPGQQPFQDWFFKYKFEEPYLMYRQWRECTKAIIAGKPPKFKKHVKITEEYLLYARQRLAGDRELAKRYNQNHGIIALRNDFLTFKNIKGSDAANFETLHGGGAAADVEGDIILVPIATIGCGKTTVGLALTHLFGWGHVQNDNITGKARPPRFTKALLDILDEGVPAVFADRNNAQKHERKQLITDVKIQHARARLVALHFVHNDLDKVREVCRDRVFARGDNHQTIQAASDMNKVRGIMEGFINRFEPCDPEQKPDSEFDDIIDLDPAVGSRQNLEIVIKELHRMYPKFMPNIPSAAEMDEAIQVALEGYKPDLRHVIPDRGNKNKKEPKQNGQQQQQKQKKKPLEYMSVDMTTKDVLSTLEKAFAAAGPEQSRFFKQLHGTRRVQPKFHVTLMHKAGAKENPQLWDRYLRINELEGPNSPDGKLGEIDVQLERVVYDDRIMAIVVRLIPRPGDENVNPDGSEPAEPKWKCTNRVAHITVGTRDDNVKPKESNDLLAKWLEHGTGAETGIYDLLIDGKPTLQGVVRGILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J783</accession>
    <name>A0AAE0J783_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_405932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677697.1">
        <property type="nucleotide sequence ID" value="XM_062823809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J783"/>
    <dbReference type="GeneID" id="87860963"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="506" mass="56625" checksum="C1B41E6A3A827FBE" modified="2024-05-29" version="1" fragment="single">FRNQGRWEEAEKLEVQVMEMSKAKLGADHPATLTSMGNLASTLWNHGRWGEAEKLFVQVMETSKAKLGADHPSTLTSMGNLASTYRNQGRWDEAEKLEVQVMETHKAKLGADHPSTLTSMANLASTYRNQGRWGEAEKLEVQVMETSKAKLGADHPDTLTSMANLASTYRNQGRWDEAEKLEVQVMKTFKTKLGADHPDTLTSMANLASTYRNQGRWGEAEKLFVQVMETRKVKLGADHPSTLISMDNLASTYRNQGRWGEAEKLFVQVMETRKTKLGADHPDTLTSMNNLASTYRNQGRWDEAEKLEVQVMETRKAKLGADHPSTLTSMGNLASTYRNQGRWDEAEKLEVQVMETRKAKLGADHPSTLTSMGNLASTYRNQGRWDEAEKLEVQVMETSKAKLGADHPDTLAAMAHLASTYRNQGRWDEAEKLFVQVMETSKTKLGADHPDTLTSMNNLAFAWKSQGRHEDALALMQDCVEALERVLGPEHPYTLSSLTAVSKWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7L3</accession>
    <name>A0AAE0J7L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_552529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677471.1">
        <property type="nucleotide sequence ID" value="XM_062829895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7L3"/>
    <dbReference type="GeneID" id="87867049"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3338020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="605" mass="66067" checksum="45644B98E28A74AD" modified="2024-05-29" version="1">MCGIHAVLTPPGITHTASPDLTRCLCNRGPDYLGQVERRVTSSSSTTSDSSDSWKLKLTSTVLALRGDHVAKQPLSCPDTDKGSVLCWNGEAWRINGEPVSGNDGEEIWRLLREVEASASATATSSTEEEKEKKILDVFRAIEGPFAFVYWHEAGRKVFFGRDRLGRRSLMMKRDERTGEVVFSSVAEGVAGGGDNANATANATAIGWKEVEADGIYVLDLGLLPSSGEGVTPAVLEPLRRDWIEGVDPAEFVSSIGRFNKSLPPASGYAPLSATSPSVAALKQQLIDSLSLRVLNIPQPPGADKVAHDTRVAVLFSGGLDCTVLARLAHEVMDPEQGIDLLNVAFENPRVVAQLRKDHAKNNGGNGEVDVDSIDFYEACPDRITGRKSFAELQRVCPGRAFRFVAVNVPYTETLSHRQQVISLIYPHNTEMDLSIGYALYFAARGQGSCTHLDGRVEEQYTSPARVLLSGLGADELFGGYSRHPSAYERAGYAGLVDELLLDVGRLGKRNLGRDDRAMSHWSKEVRFPYLDERLVRWAMDTPAWEKCDFENEGGEVEAGKRVLRLLALELGMEGVAKEKKRAIQFGARTAKMESGRVKGTTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7M2</accession>
    <name>A0AAE0J7M2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B0H65DRAFT_434320</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677879.1">
        <property type="nucleotide sequence ID" value="XM_062825123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7M2"/>
    <dbReference type="GeneID" id="87862277"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.560:FF:000005">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="199"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAK3338428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="471" mass="51041" checksum="DC5F5BB8A85F68DF" modified="2024-05-29" version="1">MTDSIDLPASSKPAAPTVRTAYIALGSNLGDRIGWIEKACKEMDARGIKVKRTSCLWETEPMYVLDQDRFVNGACEVETTLEPLELLDALQDIENSLGRKKIIDKGPRNIDLDILLYENLKFDHERLKIPHIGIPEREFVLRPLAELIPDKPLDHTRPWSLTRDLLDAIPPSPTPITTMTPLSSHGHPPIQALNPSRKTHIMAILNMTPDSFSDGGQHASSGLESTIQSFLDAGATMIDVGGQSTAPRTPQVSAEEEIGRVVPAIKMIREKFSQRDVLISVDTYRASVAEAAVAAGADIVNDVSGGSMDPDMLPTVARLGSTICLMHMRGTPANMSSLNEYPEAEGGLIGGIAKELVGRVAAAEAAGIRRWRIVLDPGLGFAKVGPQNVDVLRHLEEMRSWPGLQGLPWLVGSSRKSFIGQVTGVPTPKERIWGTAATVAAAVQGGADVVRVHDVKEMAQVVAMADAIWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8N8</accession>
    <name>A0AAE0J8N8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_553053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678046.1">
        <property type="nucleotide sequence ID" value="XM_062829939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8N8"/>
    <dbReference type="GeneID" id="87867093"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042017066" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="100" mass="10886" checksum="E3047E424AF6BD72" modified="2024-05-29" version="1">MKLQFTAKASSILGLLLTRSAQASFYVCTQENFVGLCQEYSLPYNDCHDFESGFFRKVVSAGPDPKSGSCTGAELSLRYPGMLNLGDWNNKAASFNCAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8R7</accession>
    <name>A0AAE0J8R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_475371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678445.1">
        <property type="nucleotide sequence ID" value="XM_062827304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8R7"/>
    <dbReference type="GeneID" id="87864458"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042114640" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3339085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="330" mass="36698" checksum="4455A4BEB332EC65" modified="2024-05-29" version="1">MAISKQLKLLFTSGSLIAAALASPAQKPLSDDDIDDTPLPLVIWHGLGDSYSAAGLREVGALADAVNPGTLVYFIRMDDDGSRDRSATFLGNVTEQVAKACADIAAHPILSTAPAIDALGFSQGGQFLRGYIERCNSPPVRNLVTFGSQHNGISAFRDCPWSDWVCRGAMALLKGNAWTQFVQSRLVPAQYYRNPDEYEQYLEHSNFLADINNERKFKNQTYRENLAKLENLVLYMFEDDTTVVPKETAWFDEVNGTEVTPLRARRMYSEDWIGLRELDRKGGLHFRTAPGDHMQLTDQLLNETFAEFFGPLKKAEKSAPRPFLLGAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J985</accession>
    <name>A0AAE0J985_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fermentation associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_580423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678615.1">
        <property type="nucleotide sequence ID" value="XM_062830794.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87867948"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="258"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="2522"/>
            <end position="3150"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="3245"/>
            <end position="3314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2433"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2575"/>
            <end position="2602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3164"/>
            <end position="3241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2584"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3184"/>
            <end position="3194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3195"/>
            <end position="3222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3223"/>
            <end position="3232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3339255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3314" mass="368592" checksum="8F5675F0E83812EA" modified="2024-05-29" version="1">MAIRSNFFGDEGGFNGLFLGSLIICGALSIFSLLYFNRVFASLLSWALRTWTWHQYKVYIDIQALQISLLGGRIFFTGLRYHGANETILVQNGYITWKYWLRRVRGVKISAKDARGHNETDTDSDADPITEQLPTPKLPCRISVCLSGLEWFIYNRSPAYDSILSGLTDLQEDAVPAASGTEPVGAGDGAGTHESGNTRKRRSKKRETLRKSEQTQRSGATQYRNGRPIQDSSTGRASTMASSDSEDEEEHERDGQFSHELPLFLQMLPLQLECTKAAMVMGNENTKAILIVKTESMEGEVDASATETPDPYRQFFRFKFNHPVIEMKENLDFKEDQADRATRDKQTTTHDPISVHHRPFLKQQMRRLMGCLHRLRRIVPFRRNRSVESLPLDAERDIRTATSPISTSNPNNWQGLSRYLDSKAHDVGGTRPGWASSEYAAVPTILDSPEATLTILWDVVGKVRRPHTNAGEKATGSLHNINGEEPPAWSIQLSVKGGSINYGPWADRQRADLQRTFVPNLCKDATPATRLPVGAYRVPTKFNFYVEFEDTVTLRVPVREESKNWKWKGKDPATKPPPEPQTRKHRGRPKKAEQPATIHQRPYGWLDIKVAKDATMSYTMDMVAGVAGFSNQLVLELPSTEISSSINHELLWKSGKQQISCDLSTPLGWNALREWRFKIISSDLDLFILRDHVFLLTDLVGDWASGPPPEYLVFTPFKYHVEFQMQNLRLFLNLNDANIVNNPIDLDDNTYFIVASPLLQSKLTIPIDNYRPNKNAIPFNITASNASVALHVPPWNTQASFLDTKEVGRLENMVVDGAYHYHTITSPANTDTLILNFSTQSLFARVYGFTVRYAMKIKDNYFGEDVHFKTLDEHQDMLRLKDQNPDAETTNKPPPKKSSDLDVILSVKCDEPKILIPANLYSSTRHVLIDTASFGADLRFTNYFMEMDLEVAPLQLSLGSSDSSGADTPKSATGSNTQLFIDGIHLYGHRLFGLPHAEPTYLCNWDLSVGTITGECTTEFLTTLVRGGNAFGFSFDDDENALISAASIVLYDITFLRVYVQSVGIWLHVEDAAFLLSTGSINVDFNDWARSHYSRRANIRIPNVKVSCINAENAARHKMRANHPIETDAILETSVSLAIIGRKHDFSDQKRRQQEFVRREDQRTHRTPFLLLSEAPEDFIPDIVDPPAQSVPPMPTPTKADEVESDRMTTYSRATSKPSRSLRHKSSFLSFTSESSVVRPRSRRSSVRVKQADRLSPFASYGRQSRGSRGHIRDISPSTRHSGFYSTFGDNAERQDLMHNTVAFSSQYFAPYFPLENLKMNYKDAAKISVERDDESEAERNSLTFDLGDIDPDSIQEDCAYSSIILEMPSGVKAICNPTALRHVVTLLSSLQPTDPEDILDSIQSDSMKAIFGMQKDQKMKGHVEDILIKIPRADIRFANPFDSDPANPLGEEEDQYNLSITRLALASRSEIKWRDAFKPESKQTRSSFHLRLQSIEASAAERYHDAFNSPAAVRASVENIMISMGTRDVTYLDVDVGTITSSTSSEKVDYLASLIHRTSVLASDFGRLFNEKSTYEENMPKNLVKRLIEDGQGAPDPGFFVRPSAILRSAPEHLRSFDCWKLVMRLRQMWAVRSQWEKEQLGYTCLDKTQTPSANIREEVIAAFEKWRSWDLGNISDSPLINTIFGPAKNGPGPTKERPTLAVVKIKQIQFILDPGPKQNEIMAVALSIRADTRRASDAESNARNAETAGRLTILNINCSDAAINLNWELCELATRLLELVNKLESKPSTAPKMASLPSTKKTEDHTIHCVLAIGHGSIALETINLHISSIGSGLSASLLLQLGQEEKMDTNMILTCDSVISSLRSHSEGVAKLVLQRPSVFVSHELKKSQTIDSHTIKATASSHHLSFVVKQDPVYITELLDLVVRDEVAKIYKLGKKVPSSAPSDSAPKKIVDRLSAFRVNVAMFMDQYTISIPLLRSLTYTVNGTVARVAMAANFGREIIFDFDIKENSHEIRTKMNNVTKRISLLQIPPTNGQIRNHTTDSEHSVTVFASLELVELDASAVYSFLSALNRPEVSSAITELQQQGKAIQEHIKEISGSNQASDMRASSPGTPQAESKLLVYAINLTFAGLRVFGNSPLNSEVEPFAHIAFQLDKIHLGTANRVEQQGPLLAYPEFHVNIREVAFEIQKGDAETMRSCGNLGFGALITASSKHDDDGKEQRLFNVKSDAFHINLSPDTISTVVDVLGYMGDKIKDLDTTRELEYLRKLRQSKPRIAINDLEMEEEDQDIVDVFLSSFTYTFEICNIQLAWLVNHNHPRELPDPDKEDLVLSLDKIEFSTRTRNSARLTIENLRLQMVSLEQERRLRSPNSALLPEIMFNIAYVSMSDTRRLAFQAVGKTLDIRLTSGFILPAAHLTRSISLSINNVQQASQNWNPSPPAATQAASLPEPQEQIRKRSILGSKRLESLLVDADFAGAVVHLTGKRTPSDLVSASRLGKSSTAGKSGQFGQEEWVNSVTTLRSPGLALKLEYCDDGREDPSLFAEVKIDASSNILYPSVVPLIVEMSNNIKSVVSERGDGANPPSPPQAPPPKAKPAEEDGILGADPTAVLGRVKLNLGLRVRKQEFSLSCQPIALVAATASFDDVYFTANTVRSADQGNFFAISGAFSNLRASVQHVYSRESTGSFNVDSIVLSLMNSKHVSGTNGLSAILKVSPMEVSINAKQLQDFMLFQEIWVPRQFTETTPSSPVAKLVTETSQGHLVQRYQQVAATAAFPWTATISITALKISVDLGQALGKSTFSIDNFWISSKKTSDWEQNLCLGFDMIGMESQGRMSGFVALRDFKLRTSIKWPEREQALNETPLVQASVAFSQFRVKAAFDYQAFLVADITSMEFLMYNVRRSRQGMGDRLVAIFDGNAVQIFGTTSSAAQGVAMYQAFQRLIQERKANFESSLKEIERFMRRKSVTAPAAVIKRLDQKSKLASEADDTLSKSPISLDTDVVVTLKALNLGVFPGTFADSQVFKVEALNAQARFAASIEDRRIHSILGLTLGQLRIGLAGVRATGGAPKTLSELSVEDVVQSATGSRGGTILKVPQVEAVMQTWQRPDSRSIDYIFKSAFEGKVEVGWNYSRISFIRGMWANHSKTLQRTWGKELPPVTAIRVTGVPEGPAEDTTTTTTASGKDGDQKQKDQRQSSTTTSTSTPADGSSSSSSFAPGSASQETEKEKDHKQSQSNKITAEVKVPQSKYEYTALEPPVIETPQLRDMGEATPPLEWIGLHRDRLPNLTHQIVIVSLLELAGEVEDAYSKILGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9G7</accession>
    <name>A0AAE0J9G7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_432719</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678899.1">
        <property type="nucleotide sequence ID" value="XM_062825025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9G7"/>
    <dbReference type="GeneID" id="87862179"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3339539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="172" mass="18953" checksum="92D5C0805EC4B0E4" modified="2024-05-29" version="1">MLSGLANPRQAAVQLMNFGLILSTAFMMWKGLSVITDSPSPIVVVLSGSMEPAFQRGDLLFLWNRNVVAETSVGEIVVYNVKGKDIPIVHRIVRKFGKGPEAKLLTKGDNNVSDDTELYASGQDYLVRKDIIGSVFAYIPFVGYVTILLSEHPWLKTVMLGLMGLVVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9X1</accession>
    <name>A0AAE0J9X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_471520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679109.1">
        <property type="nucleotide sequence ID" value="XM_062827105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9X1"/>
    <dbReference type="GeneID" id="87864259"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="386" mass="43541" checksum="83C6F661E0F0B131" modified="2024-05-29" version="1">MAGRAPQHALWVGCRAVPEALSKPAQQSRCLSSTVPRQATYPVVSFNKTSSPELKEALETLREKVILPTYLPPELRQKIFNKKYEKELAHDPVTIQIDGQPQRFTYINMLTDMPNTPKNIRVALLNMKNGGDFANLSGLLEGMHRANRKLPYWLSAQIVRKACKAGHLQLILNVVRDVKRTGFTLERHETVNELLHWIQRSAWKSDYSEPETRKALKEVQEILEALEGDERHTSKDRKRQQAVTGFPYQRDPQFLAARLNLAAELAARQPDSANDVKNLVKYAEQLVKLWPADKALLDMYTDEAYVARVDVRYLIKPQVHLRYASFILQGLKQAAKIVGQTGHGPLAAQLINRAAAVEAESQLAYAKVDDGMAGQKIYEMVVGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA72</accession>
    <name>A0AAE0JA72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_577814</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679180.1">
        <property type="nucleotide sequence ID" value="XM_062830707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA72"/>
    <dbReference type="GeneID" id="87867861"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071265">
        <property type="term" value="P:L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="16">
        <location>
            <begin position="436"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="441"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="441"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="525"/>
            <end position="526"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3340238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="769" mass="86235" checksum="809FA7C96CACD71C" modified="2024-05-29" version="1">MVQSSVLGFPRIGVLRDLKKANEAYWADKISQEALLAEGKRLRLAHWQIQKDAGVDIIPSNDFAHYDHVLDHIQLFNAVPERYTSQKLSPLDEYFAMGRGHQKGGVDVPALEMVKWFDSNYHYVKPTLQDNQTFTLAQDPKPVREFLEAKEAGFQTRPVLVGPVSFLALGKADRGSSVDPITLLDKLVPVYVELLKQLKAAGAESVQIDEPVLVFDLRPEVKAAFKPAYEAIAAAGDAVPKVIVATYFGDIVHNFDVLPAFSGVAGLHVDLVRNPEQLEPVLKQLGPSQILSAGVVDGRNIWKNDFAKSLAILQTAVKALGPERVIVATSSSLLHTPHTLASEKKLPSDVYEWFSFACEKVKEVATLAKAVTEPEAVKAELEANAAAIKAHFDSKRTNDPAVKERQAQVTPEQHIRKAPFDTRYAEQKKHLSLPLFPTTTIGSFPQTSEIRVQRNKFTKGEISAAEYERFIEQEIELAVKIQDELDLDVYVHGEPERNDMVQYFGERLNGYVFTTHAWVQSYGSRCVRPPIIVGDISRPAPMTVKESKYAASISKKPMKGMLTGPVTCLRWSFPRVDVHQSVQCQQLALALRDEVVDLEKNGIYVIQVDEPALREGLPLRKGAEREAYLKWAVDSFKLATANVENSTQIHSHFCYSEFQDFFHAIAALDADVLSIENSKSDAKLLKVFIDEEYPRHIGPGVYDIHSPRVPTLDEFKQRIEEMLAYLKPEQLWINPDCGLKTRKWDEVKGALSHMVEAAKYFREKYANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAF9</accession>
    <name>A0AAE0JAF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_476214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678712.1">
        <property type="nucleotide sequence ID" value="XM_062827348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAF9"/>
    <dbReference type="SMR" id="A0AAE0JAF9"/>
    <dbReference type="GeneID" id="87864502"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3339352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="310" mass="35300" checksum="FE6CB51422B0DDD9" modified="2024-05-29" version="1">MSLSNCRFYEEKYPEIDSFVMVNVKQIADMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKEKGYIDLSKRRVSPEDIVRCEERYNKSKIVHSIMRHVAEKTLVPIEQLYETIGWPLNKKYGHSLDAFKLSITNPDVWNDIQFPTEAVAEELKTYISKRLTPQPTKVRADVEVTCFGYEGIDAIKTALRTAEARNTEETQVKCRLVSPPLYVLTNTCLDKNAGIARLQEAIQDMRTSIEAAGGHLVVKMEPKAVTESDDAELQALMEKRERENAEVSGDESVSESDDNIPETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAM3</accession>
    <name>A0AAE0JAM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_250777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679096.1">
        <property type="nucleotide sequence ID" value="XM_062822455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAM3"/>
    <dbReference type="GeneID" id="87859609"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="225"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="773" mass="82782" checksum="7886807C03A02B87" modified="2024-05-29" version="1">MSSSSNNPPPRPSPLRTSRSFTRLDPPSTPTDMTRPKRASTIQSPVKDSSEMPDTFESRVSLDIEPPRSSIDLEGLPIELVALTDSFIDGLVAKVHPTPPNIDSLSQRFQDFYATAASHIQTHIDSLATRQKRDEFATSSSGTRQSAASILRQKASQLGSSSKEKLKAGLTRRESEMLTPDEYAERRKARKALEQQRILLEEAVERRLCEGIYGRIYRHHTTQDEAQDDKLRSKTAALAVVGIGPSDLGVDIGDIDKSDPEAVAKRTDEVRDWLEGARKELILMNQSRYPLGKLNHLKATHKAIIDTLSHFHPSSSADELMPMLIFTLITLPPENLNVISDVNFIQRFRWEPKLVGESSYCLTCLEAAISFLETVDLSTLRADEAPTGPAKKPTGSSIPRAETFPPAYSAGVSSTPSPSSESNNSLKPPLSRDAVRLRDRRLSDLVTQPAQAFNAASDAVFTTADQSLKTIGISLGDSYKFLVGKMREHQEAIVPKTLEDARKLIGTPPPTLGMEDGDGHSMASGVSVRSAASSVHTPDEAGSLHPLKRSNTPSRTAEDRVLSIIGGRKASATRDPSVDSASTNRSVSGSGKRLTVEERAAAAVAAGLSGGGSASKEAKEGSTTAIAVGTTPAPTPAPAASSNPALIDSVRNLGSSLNPMARFSQGISGLRSFGRTTPAPAAAVPPTPVAKDKEVPPVPGKGTPVADGGDLATAFPDLAPALPPKETPKIEPPIKRFMEIQNPADLRIGEVLDLLRDYRRLAGALKDAGAFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAP2</accession>
    <name>A0AAE0JAP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_261255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679435.1">
        <property type="nucleotide sequence ID" value="XM_062822616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAP2"/>
    <dbReference type="GeneID" id="87859770"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="109"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="717"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="833"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="958"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1093"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1152" mass="125024" checksum="C071709BACAD6DD7" modified="2024-05-29" version="1">MRASTLVNVRHLLCLYLFFTLTLGGLIRPEKRQQSKISTTVSPTQVPTSAIEITINTPTSTSVIQSSSKSSILVTATETTNSSSVFQVTIPHGQLPIQPRITPGWAVSGAILIVTGIVCGLVGIQKRWLHTFLTTGFLASLGTTVLILYVADPQVSDAVQGAYVVAAGCTGMIVGGLAIIFQDLAEGLACLLAGFCFSMWLLTLRSGALIQHSGGKVAFIILLSLAGFCLYFTRWTRTYGLIASISFSGATAAVLGIDCFARAGLKEFWAYIWDLNDDIFPLGTVTYPLTRGIRAEIAAIMVIFAAGMVSQLKLWRLVRNRRESEFTDHERNLEAEDEKTARQLEEARARDLREWERKYGDGKIRQVPPSEDSGLGDMDSEKRVLRHSQQSISAVTTTRSRSRSTTGTDSGTSKYEYAVERAATPSSLAQATAAAMACSPTRNLKGAIKASDDGISSESNTDIGSPTIDEKEVEVRVSEAGIDGPPVAVDDDEGNGLGQTAQHRSTTVIRRLSNSSAKLFRNLSHKPAHREAERNQQAGESREGGVAATWKVRNDTDSVAVNLDDLGFVSDDDENEDDQVEESKVPGFENQSNEDAGKRIEPMAEPTEEVTDKTLSEVQSHEQGHPQAQQESGTPSTSKGYALMFNEPYEYKGDKEKDQPIPTNVPASVGGSEVRSSGTPKSDESSGNSLLKDNIAQELSPIALYYRTNEWAKHLDAADLPEEPVTPQPIDDPKETDSNLPSEKPAPLYLVGLQQTATNASVPRAIPRTTSLVIDYLAQQRGIHRSSSRSPDGIYHGPDLIPKPEPVAATRASPYRSASETLKGLTSRLFTETITEEGGVQSHRRGTEQVSRESHQTSRPVPPEASALLSAIDPYGPSPAQGVSRHRTPSTLIDTREVLLRSKSHGPLFNAPAMEVVYNGTPAAQPHLVQDSSCSPPIDIDDIPLSQRRKIIRQSSLAYESKNNRSRDILRDPSPNSKLNPQSRNPSAPTSPQPARQASNSSSTSDAVRQAKLANFRKSVAADLRASSSRNALNNIATPIIPPSSSSSPLQQPTTVYDPYTFGHQVGVMTQTQPQQQQIHPGLGRRVSTQRNTYGYGQQQQQQQDPTSTGAAIEIQQRRSSGQPQIQVAQAHRAHRAHRDAMRRLQAGAKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB94</accession>
    <name>A0AAE0JB94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_551234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679765.1">
        <property type="nucleotide sequence ID" value="XM_062829797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB94"/>
    <dbReference type="GeneID" id="87866951"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="145" mass="15396" checksum="5D4D3FC5A901D50F" modified="2024-05-29" version="1">MASLVEISPIAEFTSVLATLPSASSEVTQVVTGVRVSTNEILDAIKNNPVNGTATVASRGLDKRASLGVYLCRDAPFVDGTCEHIFGNPGDFSMCDSTCPSNNNENGCRQLDSSYPSRSNLNTAANNVCGVNSNDKIRSYRCRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB99</accession>
    <name>A0AAE0JB99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA recognition motif 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_260895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679426.1">
        <property type="nucleotide sequence ID" value="XM_062822612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB99"/>
    <dbReference type="GeneID" id="87859766"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="516"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="630"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="712" mass="78594" checksum="9B55128AECB9E2C6" modified="2024-05-29" version="1">MAQARDTGFNPSSPHSSSGGADSYKHEGTPDTRLTAFSPDDNSARSNKLLNRTLTLGTATSQDAHSHHFHSHNSSDGYSVAPASGSDKDPFISTSSISKPDQKLSPTASSFLPVSVSGPLVAHGSVNGAQNGMQGLLNAVQPSYTKQHGFKAADRLSTDLNLSRYLVFYSSQPMRVAGVEEYLQKLERLGSPLQGKHHAVQEGGRVLLRLTDIRDARKVHDNVQLGNPEWRATYIAPVDFFHIAYPGTSVDPVSEGQLLVLAFPGSGYAFPYAQSQVEAIVYNFLQAEGELFAFQRLNDSTQGLFKAIAEFSDVDVAVAVVSKFNGFTVNGIQLLLTLCQPDTPALGLASADAYNPPRSQVQDITNIFQNMSVARTPQSTRPLVGGGRATQSPASISVPQQQIAMYPVVYQTPINSGNRYVLDQTPTRGHSVAPLTPLTPMSGGASVMNSSIYTPPATPMAMQNDYTSPRSMQQFGRPDSRRQNAMRVSRSPYHNVAGHHNHVDANRIREGIDVRTTIMLRNIPNKVDQAMLKRIIDESSWGKYDFMYLRIDFANDCNVGYAFINFVDPLDIVDFVNARGNQRWNCFKSDKIAEISYATIQGKDCLVQKFRNSSVMLEAPHYRPKLYFTSNGPRPDLAGQEEPFPEPDNQSKMKRSCENAEHVGLFTPNAGQHFRDEQRRRRSQYDRGTRLAALEEYDYDTQTQPQAIYPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBC7</accession>
    <name>A0AAE0JBC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_541498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679844.1">
        <property type="nucleotide sequence ID" value="XM_062829174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBC7"/>
    <dbReference type="GeneID" id="87866328"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="201"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="391"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="136"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3340902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="490" mass="54780" checksum="37A03F8E6E66589F" modified="2024-05-29" version="1">MPVDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQNQIHAERQQRKLQIETLKYERIINDTLIKRISSLLASLKAHASEVSSRNPGEVAFQAVMESAAGLDPKDDQPPPRPAGVHNAEQPLPTYTKMMATLLDDVNKTLEEKKVEQDKRYEATMAEVEEHLKKVTNLQGELLKKLDELEKIEKSKITSESIYTGFDSTHINKSKPSTSGDKKDASKVELLNPNYSATDSLPAPSKATDDDDDDAEIEASPAAKQFASIKAGDYRESLAFLTKHPEILTEKETDGLLVLAFDAQLQNRDDYARNCVHQALLLQYCRALGRDGVALFFKRITTQGHQAQEVFFKDVQDTYYKIKTRAREINLQRAKEEAKGGGQEGVEQIQLHAVEPGTVININIPPADSEDPEVQQARAIFESFSPEMKKALETGKLDEVNKVLGQMKVEEAEELVGKFGDAGVLSLEEEIIDATTQEGQEKWKEIEAAKKHVDEPAGDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBF8</accession>
    <name>A0AAE0JBF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_497628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679192.1">
        <property type="nucleotide sequence ID" value="XM_062827803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBF8"/>
    <dbReference type="GeneID" id="87864957"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57570" checksum="54309689056112CE" modified="2024-05-29" version="1">MRLFTPTTRTTVTRTITTRRFLTHRVLSATRTTTTITTNHHGSHIRAYSSEKGTTPPSPLSSHQSQSQSQSQSSTFNPETYLQTATTTLSLIPPKLIPDTLHPTQSHLLSLALSSHLPSICLPPGFNSSSPSSSTPIFPWPTNQEEEYNQLQLPPGYHLIYYPLQTPPHLLFPDGTDADHCPGSPFTRRMWAGGRIEFGKGSGERFKVDGRKTICVETLGEPVLQVGKDGKEEEQRVWVDVWRRYFTFPPEEGMGRGEMERVVEGVVDDLQNEAAGAQDGGSETAKGSKGVISELRRLVFLREREPSPNHQNQTQQKLEPAPARVIRVPHQPDFFFKMTPDATLLFQFSALTFNAHAIHLNPLYAREVEGYKERLMHGPLTLVVMLRGVEGFLRGGTSGAGAGSTMTAAAADSAGTQISEAIRERLFVVPGDEPEDDGKKKKKQWEIANIEYKNLRPLFVGEEMKVCIRLLPNKEKKSDGDGDRAGLSGLDGGRRERVDVWIEAPDGGLAVKGTVGVEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBG6</accession>
    <name>A0AAE0JBG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_276156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679860.1">
        <property type="nucleotide sequence ID" value="XM_062822809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBG6"/>
    <dbReference type="SMR" id="A0AAE0JBG6"/>
    <dbReference type="GeneID" id="87859963"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3340918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="262" mass="28667" checksum="9CD1AEB13DFE5CD0" modified="2024-05-29" version="1">MAVPGTQISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKDFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKSGPQKSLPDAVTIIEPKEEQPVTQPISQDYGAKAAQVQAAAEAARQEEQAGEEEAAAPAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC89</accession>
    <name>A0AAE0JC89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_430935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679961.1">
        <property type="nucleotide sequence ID" value="XM_062824915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC89"/>
    <dbReference type="GeneID" id="87862069"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3341019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="367" mass="38769" checksum="E3090F2BBEC407A9" modified="2024-05-29" version="1">MKSENRGSEILAITWTLTGLAALSLLVRIVWKIRSKKKLWWDDHVCSLSWFVLKTSTFIITIATSKGLGKHVQAIPEDNLPTIGLIGNFIGTLSILASVWSKTSFALTLLRLLSGRWTKDLLWLGVATIHVFLIVNALFMWIRCSPAAKTWDTYMEGTCWDNQVYPQYAMFAAGYSAAVDLILALLPLALFFQLQMLHWKEKLGISLAIVVALVSGAGAVMKATVISGLTSSDFTFNTAPLIYYATAESALTIIASCILSLSTLSRVVSRPQSGSGGGGGGTAGSKSPLESQSQLTSENIPLGAAGAGAASASASGQSSAAPPSSSSGIRVVGGGGGGEPGGGEVPERNRCWYKLPPDTNAWPGVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCW0</accession>
    <name>A0AAE0JCW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear protein 96-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_429445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680261.1">
        <property type="nucleotide sequence ID" value="XM_062824824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861978"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.690:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="890"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1105"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3342468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1845" mass="192314" checksum="ED216B04D442F6BC" modified="2024-05-29" version="1">MSFFGGGGFGQNTNTGTGFGSSGFGTNTQTTGTGFGTGTTGFGAPAQTGTTGGGLFGSGATGTAGGFGSNTAGGFGTGGGFGAKPAFGATPSTTGGGLFGASTTATTGSGFGSTGFGSNTATTGTGFGSGGGLFGANKPATTTGFGAPATTTGFGATNTTGGSLFGGGGTTSAFGSANNPGIGTNVPDPPGTAAVPFTPFQEKEANGSQVSFQNICFMDAYKKWSPEELRLADYQQGRRYGGQGGTGAFGTSAFGSTGFGANTGTTGGFGSGTTTTGGGLFGSGNTGTTGGFGSSTTANTGGFGSQTTTGGGLFGQQNKPATGGLFGASTTTPATVTGLFGSGGTTGGFGSNTGTATTGFGQNTATTGAGLFGQQAAKPAGFSFGNTGATTTTGTGFGTGTTGGFGTNTATQNTGGGLFGTAQQNTGATGGGLFGTQQQTQQQPATTGFGGGFGTQQPATGGGLFGTANNQAKPAGGLFGSGTTTTPATGGGLFGTGGATGGFGQPNNTQASGGLFGAKPAATTGGLFGSAPAQPAATGGLFGSLGTQQTQQPATGGGLFGTANNQAKPAGGLFGSAPAAGGGLFGSAPAQQSTGLFGSTNTQQQAGGLGTSLLGGAQNQQAPQAFSAGINDINAYGAATLFSNLPDNQIQNPGPLATPLNGTSKAKSRSILPMYKLSPANASRMVTPQKRGFGFNYSTYNSPVSTPGGLGQSLLAGSINRGLGKPVSTTNLRRTFNAEDSILTPGAFSANNNNRLLGCSHKKLVINKDMRSDLFQSPTAKGKLLQDGNNTSARKLTKRVSFDTSNVEATQNGAASQQEFHDLDDDSDLGFLKPSSANGRTNGAVNGSKASDASLEMEQIKGNELAIVPEESSFASSSTVDAKPVKQVDAGSYWMSPKLEEIQAMNRVQRQSVVDFTVGRENVGSVRFKVPVDLSNIDVENLYDNIVLLVPRSCTVYPNAATKPPVGKGLNVPALISLEHSYPRGGLRVGGRRLEKHIEKLKTITDTTFESYDIPTGVWSFSVEHFTTYGLVDDEDDSEDEDITEVEPTPRPSTEAVVVKNEFTSPEVDPDDTFEYRHSTGRRAIPGAFDQRAMYDDEELLDADQQQGMHSSHPKGADAPLPSREWPDDESMVDGQDAYDPDDEKSSQLDLDEEQYDLALTQIADNTNNVPAGILRARMRAVKRSTAPTKIEVAGGDDWTQILQASVRAPRTVDRNLLREQNESGEAWEAKESGSPAPREPVVHEGQGFATSIDLMKSLFEQARGPAQPAPPSGGFLKWPYQKRDKVDDEAAAPAPRATWGPNELLITTANDEASLIPVEGSASASETKTALNKLQQYIEITNANHDVPLNELKDLTENDPVWDLAFLLANDEAELPAFWKKLVAADTDRLLKEAPTPEEKAIILLAGNRVSDACDQLIGGKDFRLATLVSSIGSQTKDLKTQLDDWRDSNVLSEMSEPIRALYELLSGNACVCAGVKNAPIENRASSFTIAERFNLTWMQSFGLRLFYNSKTADGELDFAKAINSFQDDIEQDKEPEPESPLWTLLQTFATREFNWAESDRLGWLLTRSIYFTHLFSFGPDAEQKLDQASVSFASSLTAQGHWVPATFVLLTLSDPVARETAIRDHLGRHAHLIGSYHEAKSPFSALRRFGVTESWIWEAKALDFRAKQDHRQEFLALVWAGNYKEANTAFVERVGPDLVIERDWKRLVKFAQLLFKVKGKLGSVQEWERGGAAVYLLYPLKVAALRNKLPPGEDEEEERRLDRLLVDGLVALGDRLKHVPGASGASDVKREAAVADMAEELIKGRVNGQSEMGGMGADPRLFGLLPEDVRGRYMRTMALEGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCZ7</accession>
    <name>A0AAE0JCZ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomeric repeat-binding factor 2-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Repressor/activator protein 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_469314</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680574.1">
        <property type="nucleotide sequence ID" value="XM_062827001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCZ7"/>
    <dbReference type="GeneID" id="87864155"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="16">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="15">
        <location>
            <begin position="505"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="313"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="606"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="695"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="609"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="783"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3342781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1072" mass="119743" checksum="91FBD347E82551F5" modified="2024-05-29" version="1">MPSAGIVYEGVLANRTPDGNNNQNPYEGTLFNGLKFWISQRVPDRKSLEESVKANGGKTVLLEKHADILIADHVLKNAPVGSVSWKYITDSISEGQLADIDLYRIEHATAQGARPVGSTMPTKSTRTPYTPQDDNILIHWVVQKERSGAYTRGNKIYMELAEKYPRHTWQSWRDRFSKRYDHQHRDTLVKLLPQDYQPPPPAPPPSHTPAPVCKKENVKVGTPSVKTSTVHTPVPGRSQAQQSSSVPASASGRVAFTEEDDQILIRYLKQMNRQGESLQGNIIYKEFAKQYPHHSWQSWRNRWVETLQATTNLEEDDPAAPATPAAPKPTEPSLPEPTPRVITRPQVKATPQSADQAAAKRRLSAALNRARQDVPTKSSPMGPVKATVTSSAHKKSSPRSTPSRLEEINKRARLVHEEKKKIKSASIIQRAWRSYQARKQIPWRQSLILFQALAQGSLVRWACAPALEESQSEQLYEEAEVYGDDGESVDLGQSLEEGISSEPTRTPREQFYEYFSRYNEALGTNPVPWVTIGGKAVDMWDLRRAVTEQDVPAHARDWQEIAELLDFDWIAEPDVPNQLQAAFQEHLAEFENFYKEYQEAELHELNQGTDEDSEEGEETEEAENDEIVEGEEEVDADGAENTTLPQDPNTTEFRSSPPIIGALKSSGGLKRNLDQIISSPLANMTRKRLRYDVEDEVPESPPKRWQFPLTPIPEVTSRPEETADVAPVDDEEDHDDAADDMPIFGDDGDDYGVEDHRDDNEDVFTTPLQQPRQTTVERALSLRPSSASKSQKVTSAQKKSTTQPSSKNQAQYISSDSDSDSSSDAFATPINPPRPPPERRRSPIPDPIPRPSATAPAARRQLPPRDTAPASRSPPPRFRIPPDPFASDDEGGNHHLARPRQPPSQPRPSSHPHPPRSSAARSSLPAPIHQRHPKQHRQSTAAPEAVPPHAGRDLGNGIASEDPLAIINRYLALGYKKRHCIRGVHATTHDPNVAGRAIDALAKGNGLPNNVPGIWTAIDDEGLKGVDRARERGQDMDEIGRNVREVEGRLLEKHGRKRMELRRKFLRAWDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDI9</accession>
    <name>A0AAE0JDI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_576341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680606.1">
        <property type="nucleotide sequence ID" value="XM_062830655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDI9"/>
    <dbReference type="GeneID" id="87867809"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="5">
        <location>
            <begin position="351"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3342813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="694" mass="80332" checksum="ED939F46A9D1DB9D" modified="2024-05-29" version="1">MCGMARKTDPSSPRPLTTKLRRIFSFTQSSHPSAIPIPDQMSQHSSEKLRKPPPTPYDVVEAFDKVILARDKDKLTLLKLLQEDEDIDTPTVPKVLSKKAQEKFNALPDSKEKTPFEGVTKEYLQQHEEVQRREKALGFDHHCTREAEEWEVEANAVIQELKKLDVIDVYDKEARIEGYAGQKHKRVPGDRFLLNAPIIEKTRLYRAIQKIPKGAHLHIHFNANLLPEVLLNIAKDQDYMYIMSDIPLISKEAFERCHLKFSILSQKNFDATWSGRPDLFSKGEDQNESGQPKHIMRYKYEFRDKFWKKYRDAYAGDTNDPLKGVDNNDLVDEYLTRKIVFQADEAYSPHQTAKGAWQRFDSHTQMMKGLFNYRAAYEVYTRECLEEFVNDNIQYAEIRPNFMENNQVWFNDGSDRIDNYGIMNLIIGVYENFQKAHGGKVFKGLKIIYCTPRSFKPDQVKFALDQCLEMKLDKDRRHGEAKANRSSVGFDLVGEEGAGHPLSYFIPQFLEFKDKCKKANVDIPFLFHCGETLDVGTETDGNLVDALLLGSKRIGHGFALAWHPYVMQQMKKQNVCVEVCPISNEILGLTPRISGHTVYNMLANDVHCTISTDNGTLFRSRLSHDFYQIMVGKADMTLHGLRQLIEWSIDHSCMDAEERYQTRRTWEKLWKEFCDQLVMEYPSLVPGKLRQQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEA3</accession>
    <name>A0AAE0JEA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_550342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3343173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="89" mass="9511" checksum="DE9BA0F6D7F5888C" modified="2024-05-29" version="1">MTYTQQPPAANNTMTVVEPEPAHVHVSVGTKPGDIEMAQPGIAQPMDPMRPHDDSSIGLRGGDRGGMCPGRFCFCIPCPIPCDCCFIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JEA5_9PEZI</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062828239.1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
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        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
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    </dbReference>
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    </dbReference>
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            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="100"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3344757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JEE7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">DNA polymerase delta, subunit 4-domain-containing protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681263.1">
        <property type="nucleotide sequence ID" value="XM_062826742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEE7"/>
    <dbReference type="GeneID" id="87863896"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR14303">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
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    <dbReference type="Pfam" id="PF04081">
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEH6</accession>
    <name>A0AAE0JEH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
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    </protein>
    <gene>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681495.1">
        <property type="nucleotide sequence ID" value="XM_062826776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEH6"/>
    <dbReference type="GeneID" id="87863930"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016864">
        <property type="entry name" value="UCP028035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028035">
        <property type="entry name" value="UCP028035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="27"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1024" mass="116448" checksum="ABE250A8E3F1D9A4" modified="2024-05-29" version="1">MPVNGREVGQTPPQHSTMAPTRNSYLAYKRDTSYLIYWIVQTSNSIIKSLAASDSPVDGIDGAPMVPLTSAGITVAGLISLSKFVGKHIDSAPSTILALFQSVIEARTAAHAAFQQMTARTPDPDVEKSNDSHKRFIDALKESFDALGGRNWKPNSSSDESDLLANTEHAKEELDRLLANKFGALEIHRSPEADEASDQEGPQEIDTNVPRQRKQTKPGKGKKGKKGKAKKSSKPKAAPTKEESLEGVPLESYRIIQDQDGIITDYLMAVYDLVKEYMTLRNYLQGIWREVAYDGLNSAVAGALSNMAIAMVQRSASEMFVDFPDHDSYETVMNTITRGNVEKAQGMFHISQMLFEPGSNTPQRMEQQDVDIKEEFLIHAYHDLLDFVTDFQKTRTGKPTKRMLEEIRNWDPNFDLRHATKEERIRWRRSYTINWLYDLVNVFSSIVVQRNILRGEKHVYEKVDWSPKGPWDQHRRLFGLNEFAGFVTSLAMQKPGTDVRNRILPHHVFQLQCIVDSLTVTRGWSHHLLKGHIVVAPPPSYRFRPRRDVDLFLDREVTRDGRGILQAFDVLEQLFERDGALHGDMRRHAANHEILEGFHLDYMDWLGESKYRHGLNTIPPSRFSHTNPNGLWEYSPFLCGVGLEEGLELAYISGTTIWDRVPEPMMLLHLHNMLVQEGYIEKPVGLFATLQELFPECFFPDGKPPVANYDKALQTMVDRRGSPRERQQVRRVAASAADIHGILSPKVNDFFRKKSTLVILREAGWNIDRIPDADVSFPSVLGMLRITQAKHVTDPVTGKKRIEETEITKRTKAKGMSEEDMFNMTKTMGKFRAAKMKANEIPAERVAHAMQPGYSRFPDRSDPRSTRKARMAAGGECVDFADRDMLDFMKLDIQADISGERPLSALNFLWATTFFYMVFMRIEEELEKKRNPLWVRAYKEARGPLAKQKRLSLTLLAMIEQDEECLEVMADIFTNPRAGFLQFIYWDDIEFVAENVGKDPRPRPRPRSAASGGVDPDLDQCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEQ9</accession>
    <name>A0AAE0JEQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_510082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680917.1">
        <property type="nucleotide sequence ID" value="XM_062828367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEQ9"/>
    <dbReference type="GeneID" id="87865521"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3343124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41658" checksum="82545ADB51538133" modified="2024-05-29" version="1">MSTISESHHATKFEPRPTDIIVAVMGMTGSGKSTFISHCVGVDLGIVGHGLQGYSEVLKAIGVWMGDTYSKNIKLNGIIYLHRITDPRMVGSAKKNLFIFKKLCGQNALKHVTLATTMWEAVQPSDGERRERELLETQEFWGYMQSKGADVERHYNNRESAMRILSKFFTEEQVVTTLQRELVEGKKEVLDTAAGMELNSEYRVMEENLKRELQRTVEDLKEAQKAKDEESARELEKYRKQVDDKIAQVLRDREDLKVTLAKMLATSTFPIVSAPGSFNHGARGPGGAGNAGRAEAGRPGNPDSEWSYAKQQVTGRGSSRTFFSVHDPCRLCLNARQIRDSGVKTIERMCSAGKRDEPSIHPSALNGSEDCDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEX2</accession>
    <name>A0AAE0JEX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_559247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681007.1">
        <property type="nucleotide sequence ID" value="XM_062830124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEX2"/>
    <dbReference type="GeneID" id="87867278"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3343214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="283" mass="31634" checksum="6842C81C29EF8DF3" modified="2024-05-29" version="1">MGFNCTFDWVPRGLTFTPTTVDPDLHIHHGGPIEPDTIPSRYRIETRTPNPSYLTPSLWIESMMSIVTQPSKSLILLESSGPEEPGFAAPYDVIRAAFKSLGLRREQVRRVIGKSGSLTDYFFSETVSDASVELAFRWTSMPGCYVIFFGRFTTRLEMGAEGTKRMVGVVSHRGFLPISFDKAGVDTREEKTHAIESDYLMVALDKHAEELDENPMRVFTVLIQLCVYHLDEEIHELGVRIDGTPIEAFAQVSKEMAPEICGLRKACNDLLVICGGYLHAANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEY3</accession>
    <name>A0AAE0JEY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_193249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681654.1">
        <property type="nucleotide sequence ID" value="XM_062821679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEY3"/>
    <dbReference type="GeneID" id="87858833"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041781143" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3345041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="494" mass="53050" checksum="DBE47A91DF9638C7" modified="2024-05-29" version="1">MLIQSTLLALSATLAAAVKPLTVKNQFFVDASDNIFQIVGVAYQPGGSAGYDAALGKDPLSNGDICRRDAAILQILGVNTIRIYNLNPDVNHDECASIFNAAGIYMILDVNSPQVAGSLQNYNPWESYYDTYVNRTFAVVEAFKNYDNTLAFFSGNEVINDASSAGQVPPYMRAVTRDIKNYVAKHSDRKIPVGYSAADVREVLFDSFEYFTCAEDGQSDDPSRADIFALNSYSWCGNSDLQKSGYIDLIEGFSNTSVPVFYSEYGCNEVKPRVFTEVDAIYGEQFSAVFSGGIVYEYTEEENSYGLVSVNTKDQSVTLLKDFYTLKDQFAKLDWKKVQSVKSAKDGSGPKPPKCDKKLITSKDFDGNFTLPAMPPNVPKILANGVSPKPSGKLIDITDFTSKYTVKNADGSVISNLAVKPLSSDVSNSPGTNDAKIQSSGSVSSSGNSTSSGSDSQPESTDTKNTSGAAGSAVAMTLPAMAMGAFAIFAGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEY5</accession>
    <name>A0AAE0JEY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_465483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681717.1">
        <property type="nucleotide sequence ID" value="XM_062826812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEY5"/>
    <dbReference type="GeneID" id="87863966"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="142" mass="15720" checksum="9540775AA5831ED7" modified="2024-05-29" version="1">MPFLISRNNSACASNTQSKKGKEPAEEPTSHPSRPHDHGKILLGLGTLILELWFGQPLESQPSWEANFGPNGQETEFTKFNAAATWQRMVADHGGPILHNITRRCIYGNFGLATQNLEDTELIKAVYGNVVMELQRLCDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFJ0</accession>
    <name>A0AAE0JFJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_525329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682034.1">
        <property type="nucleotide sequence ID" value="XM_062828829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFJ0"/>
    <dbReference type="GeneID" id="87865983"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="11">
        <location>
            <begin position="380"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3345421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="554" mass="62795" checksum="CB1AD984ACEC095A" modified="2024-05-29" version="1">METTDKTAVSLSRAEQPSGAVAINNVRSEFRSRAEANKIRKVKAAEKSYGRGRKIDVKNVKDKKLKRNLTNLEDKYQTATLKAKEAEILLENAGGFLEADHELERTYKVRQEDIVSEVNIEVAQKKFDLKLDQLGPYICDFSRNGRDLILAGRKGHVATMDWRDGKLGCELQLGETIRDVKWLHNNQYFAVAQKKYTYIYDSQGVELHCLRKHVEVSHLEFLPYHFLLATLGTNGQLKYQDTSTGQIVTEIATKLGTPVSMTQNPWNAILHVGHQNGTVTLWSPNSSEPLVKLLAHRGPVRSMAVDREGRYMVTTGQDCKMAVWDIRMFKEVNNYFTRAPASSVAISDTGLTAVGWGTRTTVWKGLFSKEKPVQEKVQSPYMTWGGEGKRVERVRWCPFDDVLGVGHSEGFSSLIIPGAGEANFDALEVNPYETKKQRQEGEVKQLLNKLAPEMIALDPNFIGNLDLRSAKQREADKDLDAGPPDLEEEMRNRARGKNSALKKYLRKQKKKNIIDEKRLKAEEMYKQMQEKNGEKHKEKVAELGPTLARFARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFN4</accession>
    <name>A0AAE0JFN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_425606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682075.1">
        <property type="nucleotide sequence ID" value="XM_062824589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFN4"/>
    <dbReference type="GeneID" id="87861743"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="825" mass="93450" checksum="868B359C1229FB18" modified="2024-05-29" version="1">MQGIWSTVAQFRGCRCHSCLPAPNSFNNFQAVRQAQSNARSAARQRNRKALGSNVATACYTALAATAVVVDTENKERRRRELNRKIHEAKKNLATLMVDDAADGDLLRLVGSAPAARRPEPFRTRSQPTIDVLESICDYHVDSVRSLASSATEKRAAVLKLRDSLGMSWRDPRKDFCMGREGLVNCDKIIASEEVAAETLDQDREPRNEKQMEKQIDMVTDLVDDLMEAAYKASEMQGIKSYLPKDHPESAWSITRMLKKDGYPRFHHAHYDPTMTIQARRRFNQVTCNILADWKGPRSRDKYVAKICHNLLINTVPPGIHNYNMLIAGFTQIGEHVLAGAVVDNFLHKSRLRPTQGTILCLIHHYRCKRDAEGFHMLLRRLIGRDPRGLNMRSKSISDVYQDRGLMRWALESDVALANGRTVVERANLEQPVLEAIIEALIDFRRIGHAAKVFVACLDQRWTVNAELFDQLLHAICNTVDDLATRVLVDGLLSHVGAITTMILSRSFLSLKTVRKLRTVLQIRYARSTESLYDNSAVTDSTSPAYLLPKGNDRLERIATSIWFREAVQTIFQLRLTLPKVEHLLLAQPDEHLEHRLDRAITSLNLISPTNPRAVEREERAKALQRLAKLDWLTEQVEATEKAIKATTEEILNILAVTVPRDVRPLTLWRQHWDVEVPLEKRLKYDREMRTPNTGLNAVAACFARKEELDDQLADILMEALPAQTAAEIRHGARETATVPHLMALTKEHLRSYQKKPVAAVTAKPRLVQEQEQDIEQQQREASSAFTANDNLAAAEMTRRKLGFGWRSGGLSSYLPLRRVASVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFR0</accession>
    <name>A0AAE0JFR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_202912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681938.1">
        <property type="nucleotide sequence ID" value="XM_062821819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFR0"/>
    <dbReference type="GeneID" id="87858973"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF127">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042290049" evidence="4">
        <location>
            <begin position="22"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3345325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="633" mass="68543" checksum="66C02206D0DD3116" modified="2024-05-29" version="1">MMGIISTTLASVLAGTALSQASPAIRDESATERVWSSIAWVMHGDRSPLGVPGSPPNLTPLGAQQLLRRGTVLRNRYIVAAHEPDSFDVSKLIGAKLVGLSTNAIDNTQLDVLTGADSYNFHSALALMQGLYPPSTRVFNGTDGIAAALLANTKILDYPLEGYQYPVIRSPSVDDPESVSVDANNLCPQYLHSLDSFENDTQVEKTYNETLVFYKAEWERIFHGDNIAYPLNLADYHHAYAFYDHVQYLYVHDNATKSQLNSTFVDYMGSLAASEQREKHGNLTVSGKDEGDKIRAVAGRTMAGKVMKWFDSNIQTQGRTNKLNMAFTSIEPFFAFFSLSVLVDGPSDGDFKNHVPNPSAAMIFELFSKGGSDSVYPPDEDLWVRFLYDDGKSGSLPQEYALFGNGNSQSVMPLAEFKHSMGEIALNSSSNWCDVCDSPASFCLVTKGTTGGDDDTSGSHDPGSPVVSDGGNRLKMDPTIAGAIGAASAIAAIGLGLLAATLCAGLRFHRAGSEKKREQERMFRMLNLGSAYNNKGPENNRAVPDADVTYARNGIRHERVGSWEMHNGFGTNPYNGTGSTPTRGGSGLDRVYTNDAGFYSPKPSGSSSKRPVEEDDRASYFGAAPAKPRDFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGE8</accession>
    <name>A0AAE0JGE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Natural resistance-associated macrophage protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_207186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682091.1">
        <property type="nucleotide sequence ID" value="XM_062821881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGE8"/>
    <dbReference type="GeneID" id="87859035"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF30">
        <property type="entry name" value="TRANSPORTER SMF1_ESP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="555" mass="60444" checksum="CAF993EB919FAA91" modified="2024-05-29" version="1">MATTTEPGNTEVRPLPITVNNYEQDEKKVTTAQASPSVYSEQIQRPWVAGLRTWFGLRPNRHSPPPVYQPRPPPSSEPASIGSKIWKFFKFLGPGAVISVAYVDPDNYQTAISAGSEFQYKLLFMVLVSNLIAIYIQSLCVKLGTVTGMDLAQMNRRWLPRWLDLSIYVVAEASIIATDLGQVIGTAIALNILIPKLPLPAACVISVVETLLVLLFYTDTGELRRVRIFEAFVSILVVVVFVTICIALSMVDHSTGTTREILRGYVPSREIFVDTGLYASCAILGGTLMPHALYVGTSLSRARLYDYDTKHDLPSSSPRQQSPNSSSETITAYRPSLRAIKSCLGYSIAELTFTLFTVAIFVNSALLVIAGSAFYVPPEETRSSENEVSEDLYALYSLFRNSIAPAAGIMFAVSLLFSGISAGIVSTMSGQIIMEGALDIRLNPFLRRLITRCVAIVPALVIALAVGKEGLSKALVACNYLLAIALIPITFPIVWYTCRAKYMQVPAEDGTTTGTVDMKNNVVTAGVAWMLWLLVVVMDVATVVLVGLGITKDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGX0</accession>
    <name>A0AAE0JGX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_213144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682361.1">
        <property type="nucleotide sequence ID" value="XM_062821959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGX0"/>
    <dbReference type="GeneID" id="87859113"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="278" mass="31450" checksum="E31A9BE96E72B316" modified="2024-05-29" version="1">MGTPFIATLEPPGIALSPWDGSLPPSQQSPSTTSTVPKTFLDAMSIRESVFINEQQIPTENEFDANDPRSVHFVIYASINQVVQQEERDADSGRVMRPRKSETRSVPIGTVRIVPFPHAPHPVKGGRYLADELVNLEELDSETKKALERVEQGGKDRKTSLHDGEEVYMKLGRLAVLKEFRGRGIAGQLIRRGLEWMRQHPRYFSPSVKERGFEALGIDPERDARMMPKWRGLFCVHAQVSAIGAWKRAGFVVDEEMGRWWEEGIEHVGMFCRVDVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHA4</accession>
    <name>A0AAE0JHA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_158236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682965.1">
        <property type="nucleotide sequence ID" value="XM_062821198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHA4"/>
    <dbReference type="GeneID" id="87858352"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="327" mass="37734" checksum="FD714AA03DEBDE56" modified="2024-05-29" version="1">MGQRSSSPKKRSVCGLYLVTENALARLSVRQTELHTCDYQTTARPTSRLFTLLVTQRIAIWPHPVTELDHRGSSYSHRIMKLSNLSWRYRRTLEYLKPTSYTPSVPFLFLFIANKISSASILSTTRHYPHYRFQGIRPQPLHSFIGSPLALGDRRQRTSTVASPHIEEWEATVDLPYPAVKCVITQVTHASPDQRCWAVLVLGAFYDANDRILWQTEIFLGDKAEDSEETYEDSYSVSDTEEDQTISQILNQYDNEHDNDFDDAHSETGSEDSDFDYLRQRARILARINESAAQQDHWAHNSSYPVPSRLWDPIQQTWVDVYPQGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHQ5</accession>
    <name>A0AAE0JHQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_587624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682786.1">
        <property type="nucleotide sequence ID" value="XM_062830983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHQ5"/>
    <dbReference type="GeneID" id="87868137"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="314" mass="36283" checksum="EDA538B68477974F" modified="2024-05-29" version="1">MDKLPAEVILAIHTHQDLADLCSLVRVCRRLYQTLNLELYKRDVKTGSPQSLFWAAMFGLLGTLKMSHAAGANLEQAWASDMFIFPSISHCTIAGSTRTFEFETSLKKHYNKFFKHSPETYSYLFNGEKLSPAWEQRLPTFYDSFYDFNDDHPSAPKTASKDCLTPYANNFLDRPNFIQACRGKRWPKYWWHALDLAVLFRHFDVIRYLLKNGVNIAKSHSRGLCSRLCACAGSDFEILSPKRVHNPLTLAACESDLAIQKILLENLGLRDMARALTWEEVQRHEYRADMFKKGSQEEKDFVDVHDMDRRALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI23</accession>
    <name>A0AAE0JI23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_159517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683006.1">
        <property type="nucleotide sequence ID" value="XM_062821210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI23"/>
    <dbReference type="GeneID" id="87858364"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ribosome binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:regulation of translation"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="216"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="447"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
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            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
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            <dbReference type="EMBL" id="KAK3347924.1"/>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ91</accession>
    <name>A0AAE0JJ91_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_177486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ91"/>
    <dbReference type="GeneID" id="87858618"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="116" mass="12946" checksum="BCB86B0891B75D54" modified="2024-05-29" version="1">MTEARWLIQPDQRLNNGYKGHPKLPEKSHVQQFHYHQPHQFQLQHQPNFHQPRCSSDSPSPSFSPLLSAIASPVPSDDLATRNPGAEAVDTLLERGICTCLCDPCSGRCRLCESGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJA0</accession>
    <name>A0AAE0JJA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_439699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683995.1">
        <property type="nucleotide sequence ID" value="XM_062825435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJA0"/>
    <dbReference type="GeneID" id="87862589"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042092227" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="117" mass="12928" checksum="8D754E5D651EBEEA" modified="2024-05-29" version="1">MFLHLLCLLACLLACLLVRAPPLIASCLPSCTYERWMGLWIENGVLLRKGLINYLGGNASSKALTCLGPDSDDFAFMTNEFKVGQLTGFEEAVDHEKHISLKKTRKVCHSSSSPSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJB6</accession>
    <name>A0AAE0JJB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="10" type="ORF">B0H65DRAFT_171307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJB6"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3348295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="174" mass="18535" checksum="6D9E0E189B10BCE3" modified="2024-05-29" version="1">MATHIPPTLSPDAIDTLTELTTILTKFRAAAASTRQAAAASSSSGPNPSSNNGPNSNNPGGIGTPAPGAVTGTTPLPIPSTSNPNSTAASTSFTAKDLPQATDNLKHKLQRARQAVLTLPDIGRTIAQQEVEIKELEERKRKQIAMLARIREEGLQFARLEQSRRDEEGERMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJG2</accession>
    <name>A0AAE0JJG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_422686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683437.1">
        <property type="nucleotide sequence ID" value="XM_062824414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJG2"/>
    <dbReference type="GeneID" id="87861568"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="150" mass="17942" checksum="E3B21D324DEAD867" modified="2024-05-29" version="1">MKPETTASLSEQLRTINSTNPAEISAFIESIRAKDETFTELQLYALRFWYTQYHILDRLAPYASSLSGRQIFRILLSKMEDYEVEIFLERLDLILAHYPERARWHKKMAEGNLGGYGLKARVMKNIWGEEYLQVNWEKVTEEEKEFVWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK49</accession>
    <name>A0AAE0JK49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_100654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684146.1">
        <property type="nucleotide sequence ID" value="XM_062820435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK49"/>
    <dbReference type="GeneID" id="87857589"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="343"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="723"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3350851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="792" mass="86275" checksum="15916CB72DCE07B7" modified="2024-05-29" version="1">MADNPNSASTPLGVKSSSSLNTSNNIPPIPSSPPPRSSAKERRNPSITPRKFRRFFTPRVIANNNPSASQRALRDLAGPLLERSHTPSSPLRPISEEEIPDVLPSLQDGQRSSKRRKITHASTPKRAEASHVSHLPSPAATSPALLPTPELRRHRLGSPIHSIRKLPSQLALDEDEAESEESDDDDEQELPTTRRRPNRAPIQLDRRGVGAQLVQRMTGGMPGAGNRTMSCPVSDWRSETADFYSRREDAHFMTSHEGHPRSIPFCTTSCNTKSLVAVGDEEGYVRLLDTQNEFSQINMSFQAHGNAIIDMAFSDDDLLLATASGDQTGKVLDFVTQQPISILGHHTASLKQVRFQPGRGANSVLATTSRDGSVQIWDLRCRGGPVQDVAIRSEAGLHARLPRTPNPGCVVNSIYDAHSRIPQKQARNLLPGASNVDVARIGEVPGRLGEVSVTALQFLPPGREHLFLTACEADASVKLWDIRAVHTSRHHKYSTPVSFTAPLPSHANWRPFGISSMALGGDGSRLYTLCKDNTVYAYSTAHLVLGHAVELAAARPGEEPPRRRHHNHGTAHEGLGPLYGFRHRLFHATSFYVKSAIRPARNGHSELLAVGSSDGAAVLFPTDERYIKEAFAWQRQHPGQQEDDESYLVGEPTSCIPVTPARPRLTRSATTSLLSSSSLFSMSSSSGGGRPGTSSSASLFGIKGGHHHQSSNTPIIRRGTPLVRGHEKEVGALTWALDGSLVTASDDYLVRCWREGREEAADLRTGGETGGRRWGCGWADVGDQWDGDVDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK94</accession>
    <name>A0AAE0JK94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_546238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684479.1">
        <property type="nucleotide sequence ID" value="XM_062829437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK94"/>
    <dbReference type="GeneID" id="87866591"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="112" mass="12077" checksum="85155C8A7BC8BE04" modified="2024-05-29" version="1">MPSLSPVVGVGVSVTTAQLSAAAKDYPGIYYVEHPRGILQKLPSKLCRQAMHPSPSIAIGLLSPPFTTIPRARPSMAAQSWLATMGKSRKRPVETEKKAAKGSEERRGAPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKH0</accession>
    <name>A0AAE0JKH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_113540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684594.1">
        <property type="nucleotide sequence ID" value="XM_062820617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKH0"/>
    <dbReference type="GeneID" id="87857771"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="241" mass="26531" checksum="ED6FBCC7B37D8513" modified="2024-05-29" version="1">MKIGVKEASSRAKATSPQALSTLSELSIGFLCDLNWPTPGQTPHQMPNRCMAQSLPNLQPLQPTPTEEQPPSAPNEKSTIHSTHLAQTSPRPRRPRRHLYLPLTVMAQSVAAVNELHHASFKHARPVRLSGAKSSPNHTLSPMVALPTSPACHPASPRFLSPRRSRATRTLKPQGKGKGEERSRELPQWLTHRVLAEEEGGRVRAPSHPRPRLPQEGKQNQYETATPYANTQHQCACAGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKV4</accession>
    <name>A0AAE0JKV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_111295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684518.1">
        <property type="nucleotide sequence ID" value="XM_062820579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKV4"/>
    <dbReference type="GeneID" id="87857733"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="106837" checksum="6C510543A8516B2E" modified="2024-05-29" version="1">MDDYQEKIQMVRAITNYDDEPTIAAALRAKDGDLEAVINMILDDVDKFQRSYAWDESVFNTNREGDGVAAVYGPNQSFHIQPPDNNPVLYGYDPGYDPTAPSRPPSRVDNRSPIGRAVDMTTGPYPSGAPTNQQEEDAQLQQALAASMNPSGMHTPQPSTNGLPLPPQLPPPPPPQESGVTSNGAYFGPANRTDYDPNQWAMVPLRLRQTDPRPVSRARAPGSPAFLRNRSENTTNRHRIGGILTILHSIPAARNALLQLGTVPEYGYGSNSEWWKGQKILPPELQARTEQTGSGREQLFPLWSDELHRLVAFLDSTERAYGTADILAECKAPGVEERWDSEKEFFDSHLEMLKAKNDGSWDDLTMCYKKSLYGTAEGSSEEHINIWDCEGVDLTTGNLYGCLDKVFWVDRNTSIESLDGAPYSTISKLPEVFTIGLRASRGLPAAIDIPETIYLDRYLASNEEKINELQVDLSRLAYAYRKCVEEEERLTTWSDNQTGKPMDRRTMITDSIERCKDHIQQVKSRASWRNFQESSSDVDDDGDGYRLYLAGAEKEAPVSPEEAKVIAYYERKIKSLTEQAARIEKIVQGTIAPQKERILDALNQHSKALTVPASDNSWVPTAKFTLRGMTSEPNTVFLRKQEVELIDLDDGEVPTEQWFKIWCYSDNNYAVQIEKTTYEAAISQACAVGTEPLLIYASDKAMNTEPIPLNDALKAFVRFDNKFFSQELAQTEQEQHEDSRKRGPISMSSPDSKRRNRSNSLDSMATNHASAGDLDEEMRDEEFVNFANGSVYENSAEKVTTSSDHDMVDGLPPPLRREDARAPHSNDLVDLLTPPYEEKVERTENEPSNIDAAMDAASERMERVSLDEDRMDVDWGQAEVVTNTVSSQASGSSAHTEDSDITVKPNKPLDNVTTTARSPEMQERSNNSFLARAPNTPVASTTSDSTPQPYSRATMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKZ2</accession>
    <name>A0AAE0JKZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_126388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684882.1">
        <property type="nucleotide sequence ID" value="XM_062820748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKZ2"/>
    <dbReference type="GeneID" id="87857902"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="417" mass="46104" checksum="7B7DE5C343E87C20" modified="2024-05-29" version="1">MASPLNVLMVGTGEYTTGFVGGGASGSDKKVGVVGLSMFDLRRRGKVGKLGMVGVNGTKFPAIREHLNKNITQVYNNLDTSFDSFPADNAKDPESYKAAIDALQPGDAITIFTPDTTHYPIALYAIERKIHVMITKPAVKELAHHIALLEAAEKHRVYVYIEHHKRFDPAYADAKHRAKNLGDFNYFYSYMSQPKSQLQTFAAWAGIDSDISYYLNSHHVDICDSMVSQLGYVPVKVSASASTGVAVSLGCHEKTEDTISLLVHWQKEDDPTKHATGVYTASWTAPQKAGVHSNQYFHYLAQGGEIRIDQAKRGYDVAEDAAGQLMWYNPFYMKYAPDEDGNFAGQSGYGYVSMEKFVDGCRAVNAGTLTPRDLDAKGLPTLRNTIATTAILEAGRRSIDENREVRIERKDGEWRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLD2</accession>
    <name>A0AAE0JLD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_123344</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684788.1">
        <property type="nucleotide sequence ID" value="XM_062820706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLD2"/>
    <dbReference type="GeneID" id="87857860"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="20"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3351493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="381" mass="40257" checksum="13D17D0F6BAA3509" modified="2024-05-29" version="1">MASTAGKTITCKAAIAWGPGQELSYEDVEVAPPKAHEVRIQIKHTGVCHTDAYTLSGKDPEGAFPVILGHEGAGIVESVGEGVTNVKPGDHVIALYTPECKECKFCKSGKTNLCGKIRATQGKGVMPDGTSRFRARGQDILHFMGTSTFSQYTVVADISVVAVRQDAPMDRTCLLGCGITTGYGAATITANVEKGSNVAIFGAGCVGLSVIQGAQANGAGKIIVVDVNPAKEEWSRKFGATDFVNPTTLPEGQTIVDKLIEMTDGGCDYTFDCTGNVNVMRAALESCHKGWGQSIIIGVAAAGQEISTRPFMLVTGRVWRGSAFGGVKGRSQLPGLVDDYLDGKIKVDDFITHRMGLAEINEAFEVMKQGDCIRAVLDMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLG3</accession>
    <name>A0AAE0JLG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_136119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685122.1">
        <property type="nucleotide sequence ID" value="XM_062820871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLG3"/>
    <dbReference type="GeneID" id="87858025"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="90" mass="10132" checksum="1C3304B4CAF40C19" modified="2024-05-29" version="1">MFAPPVSHLASASVFIAPLDVTMSICLGGFLGELRPSSVRPPTALRGERRRSVGYMSDSVLRKQLCTYTTYTCTRWRNKREKLCVVLFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLT3</accession>
    <name>A0AAE0JLT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase 21.3 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_141117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685270.1">
        <property type="nucleotide sequence ID" value="XM_062820933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLT3"/>
    <dbReference type="GeneID" id="87858087"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="201" mass="21460" checksum="BD8C6D85CA234D17" modified="2024-05-29" version="1">MASKVVTGVVKTTAGGVVPVYHKYTVQSVGIWDRIRRAFAIDPNRSNGVPLNPYNRNPSPGSLDPLSYDDPVTLPAGDIADNPYWKRDARRNYPRLSVVGQAEAVALLSVGSASHPRVELVGENGSKQLVAAQEAGKAGGLARFFEGNGVEAGKLVLAETGGLPPLPSGEKLVEGGKWDVHKYQLAEEPSYSEAYPCRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM66</accession>
    <name>A0AAE0JM66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_543494</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685524.1">
        <property type="nucleotide sequence ID" value="XM_062829230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM66"/>
    <dbReference type="GeneID" id="87866384"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000004">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3354146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="706" mass="78504" checksum="0B11D9AAEBF3D7E0" modified="2024-05-29" version="1">MNAQELSQYLADAPPSVVRLEVEKHFDALTDKQKRYAHFISKASFAGNRIVLRQVSPESEFIYDFIIALHKASGGDWKALAEKAGVDEAGLNAFLQYAAQFLGNSGNYKSFGDSKFIPRCDEKVFASLASTSPEAEKHYKATNGAIFSTDKPGLLHLGFTDEGHLTTYYPDSPDITKDEIDAVAKWMQKTGLLPENTRLRKTKDGVFELLIASAVTSIPSEGGDIGKDTEYKITEGPLEGKTIKLVYGDYAAEMKAITEYSKKAAENAENETQQKMHTAYAKSFEEGSLEAFKDSQRYWIRDQGPMVECNIGFIETYRDPAGVRGEWEGFAAVVNQERTHAFGELVRSAPSLIPLLPWSKEFEKDKFLSPDFTSLEVLTFCGSGIPAGINIPNYDDIRQQEGFKNVSLGNVLSAKAPDEKIPFIADSDLEIYKKYRDAAFEVQVGLHELTGHGCGKLLQETSPGEYNFDHTNPPISPVTGKPVTTWYKPGQTWGSVFGGLAGAYEECRAELVAMHLSCEFQALKIFGFGDGTTDMDGEAGDVLYASYLSMARAGLTSVEFWDPKSQKWGQPHCQARFAILKSFLEAEDDFCKLEYEKEDLSDLTIKLDRSKILTSGRKAVGDFLQKIHIYKSTADVENGTKFFTDMSGVGLEYWGTKVRDVVLKNKQPRKVFVQANTYLDEATGKVTLKHYDATLEGIIQSWADRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM71</accession>
    <name>A0AAE0JM71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_141188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685273.1">
        <property type="nucleotide sequence ID" value="XM_062820936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM71"/>
    <dbReference type="GeneID" id="87858090"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="196" mass="21439" checksum="7639680CEB7620CB" modified="2024-05-29" version="1">MQTKAWSLSACPGAQRLPSLMTFVVWVFILRACLFSFRGPPLCPGPRPCRSHTCLPVAAFGFNLWEPGETQIRAVASGSNKEGPLAGLLLPQHLFLECHLDPSFTQVPPLLPSLPLSPFLTSSSPFHSIRTSICPRTRIRTPTLTSTRGSSRSLSINKRRVSAIASHICFPVCIAPCGRREPRLWYLVSSLTATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMK9</accession>
    <name>A0AAE0JMK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_142790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685306.1">
        <property type="nucleotide sequence ID" value="XM_062820956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMK9"/>
    <dbReference type="GeneID" id="87858110"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3352011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="202" mass="22270" checksum="54D6007160F16905" modified="2024-05-29" version="1">MNGSRILGRKKGVAVGFKSRPTIRLTNPLVVVSVTFRGWSCSRLNVCFPFSLAASLLTLPFGVFCCFQLTSFRRTVLPSIAPCTKPWWNGISQVSDIGSSVPLFSSSKHLTVCCTPVVQSRDIGYWPTCVHLRAPPFRVTHPFFSWTSSSSCLELVQLPLSAATMEIQPEALVFVKEKVCNRSTSGQKPKLTAGTDEINRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMZ3</accession>
    <name>A0AAE0JMZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein KIP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_4626</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685598.1">
        <property type="nucleotide sequence ID" value="XM_062826652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMZ3"/>
    <dbReference type="GeneID" id="87863806"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="217"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="708"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="842"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="937"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="858"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="297"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3354220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1009" mass="108752" checksum="3F09A4FEF0996BBA" modified="2024-05-29" version="1">MSTTVPKPARLSMGPPNSSLPALPMGKTRKSVGGLSLSTNTAMPSTPKSGVLRTPSSASNFRSSTASPATGGGLPQPRAVSSINASSKTLRKSVSINSFPQPPRGEGRPTGLPPSPLSAGASSRKSKTPTTPTYQFSGSTGSLLNGSGDGRSAARSRNSDGLISIASPPQSRSSSAQDSYSTSATQYEDMEATQSRPDTSAGSNSKRTSKTPETKGNVVVSVRVRPDASGNEHTTDGEWMVDGRRSLISYNGKEGGDYYYDNVFTTHDDNSKVYDHSAKRLVRRVMEGYHGTVFAYGMTGTGKTFSMQGTASSPGVIPLAITDIFSYIRETPSREFLLRVSYLEIYNEKIHDLLSMATGGNGPGAPAQEEIKLREDSKRGVYATPLKEEIVQSPTQLLRVIARGDQARRTASTQFNARSSRSHAVVQIVVESRERVPAGDSSGGSKRQGLLPGGVRVSTLSLIDLAGSEKAADTKERRQEGSHINKSLLTLGTVIAKLSENKDKDDKHLPYRDSKLTRLLQGALSGNSLVSILCTIQCGAGGSTAASTHINETLGTLKFASRAKNSIVSRAKRADEALGAGGDGNARVLLERYRMEIAELRKELEKQAKANSQKEADEEMERDAKEELARELEMEQRHEEQMLEMQLARTALKERIDHLNRLILSSKSIGVNANGSLSSYSLDTFNNRFSVGSARSVMTASNAGKPFLERSTSMASSSSTIGRRSLEKRSSGSGPEAPLIEAEDEDSIGEFGDGTASLAAQNRALQADVADKNRYIQTLEKRLLQARRASSSRTSLGITPGNKILVGEDHSVSTLLREKDAEIAELRARLEDKDRMLAALRSAARSRDNADRVESRTSNRNSRVFSDDGNYSLTPGVTTLNSPTGSTPTLSRQVSLMNSTRTRTKSVDEMSRMLDDMIQDRVESGQLIRGNRGSIRVAPTPAPTMPPPPPPGPVNGEIHREPVRLSQRTPSRTPSPPTQMNEPPIKLQLLSKLRTSYVAESQNPVIMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN30</accession>
    <name>A0AAE0JN30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_447995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685706.1">
        <property type="nucleotide sequence ID" value="XM_062825887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN30"/>
    <dbReference type="GeneID" id="87863041"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="348"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3354328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="433" mass="48036" checksum="3D53712F1B0CC21F" modified="2024-05-29" version="1">MSSAEVLPGSESKRWKYLDNVRTRPGAFVDPDGFDGSTVVENMDKIKILGAGGLGCEILKNLALSGFKDISVIDMDTIDISNLNRQFLFRHADVGKFKAEVAAKFVERRVKGVKITPYNCKIQDFDEEFYQQFQIVVCGLDSIEARRWINATLVNMANYENPDSMKPLIDGGTEGFKGQARVILPTMGSCIECQLDMHAPRAAVPLCTLASIPRQPEHCIEWAHVIAWDKEKPFPQLDKDDPEHITWLYQKALERAKEFNISGVTYSSTQGVVKNIIPAIAATNSVIAAACCNEALKIASSCAPFLGTPGEGEPNYMMYSGNDSIYTYTFKHEQKEDCPVCGMTARVLKVNPKWTLEELIESFATLPEAQLKKPSVRAEGKTLYMQLPPSLEEQTRPNLEKTLEELGLTAGTEIAVTDPAFVGVVFNFSLRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNM6</accession>
    <name>A0AAE0JNM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_26111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686200.1">
        <property type="nucleotide sequence ID" value="XM_062822614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNM6"/>
    <dbReference type="GeneID" id="87859768"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="462" mass="48985" checksum="31D84379651D2A97" modified="2024-05-29" version="1">MASPDPQRRPVDGRRNDGKLASNISCNLPQHALTSLLDSWVEITSQPSSSSLSSIGDEIVTTGLRVGNNAYPRRRRRSQQQAPMPASFIVSQPNPPAGTSSQDEYDETESEEDRVMTSSTEAVHPAASLPRQQTAFRGGLPVDSEDDSDDDDENATALGRPTNTAQGAFRPQPNAFSHPPSYMMHRHHSASPSHPYHPTQSRPSMPTRSQTRSHRASHNFMSPALQADNDAALRASLTTLLSCAAAARGLPKREEASPGPAGTGVMPSSQPMEFRLVPESELMAEGPSGTGLPLNQTKTRQPARTASNSSAPSAPRSASSGREQQQQQQQQGLATAERCKRGTNTAQRPARTSKKRRTSSPSPAGVVSDNDAASPFFLSPTMLTWVVSAGVVVLVSVVGFGAGYVIGREVGRQESSSALSLASAGSAASNASSSCGQEFVRSTTSGTLKRFRWGSVGRSVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNQ9</accession>
    <name>A0AAE0JNQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_414454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685642.1">
        <property type="nucleotide sequence ID" value="XM_062823915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNQ9"/>
    <dbReference type="GeneID" id="87861069"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="871" mass="98243" checksum="ACF5DC013FD26283" modified="2024-05-29" version="1">MARSSPLSPDGQFPIVLVPDNGGTEDEGTATESDTEQTESYRHRRKLDHRDERQQQPPQPQPQPRPPPAPRHPIPSMQEAFAESLFEATQGGATPKPKLRTGDAKTRREQLLEQDKSAKPPAAQWRYRPGQQTHELRRLMSQISFGVYLLLNGMANSQMSVVTILQGHIDEVDEFLETILEDIGLATKDLSERIIHLRLPMDNIEVFERMLEDRNFRLRIIQGNEKIEHIVARTQVALQQIMNDITEGLESTRDFTIYLAERQHGRWRKERPDVIDIFDAMKGNTDGWFQAFMDLEEKGNALNGVIVQLIGIISEMERRAGEVSRKTRFTIEPFTSPRHSPHASDASSVTTPPTSPIAKTPNTPPRLSLRLSSIVEGKQSSPTSYFDLKITRTPTHSTSMDIPSTLETTPEIKEEIKEEEEEEEPVYLLQPKTYTPQTSPLPSPRVFDRPKPKDEPVSYKPESPVPTIEKPKEQTLEAKVYSQEPTLEAKVYSQEPTLEAKVYSQEPTLEAKVYSQEPTLEAKVYNPRAAQPQLRPQPSKELRSQPSKPKLAPVDTRDSRPTSKQSHRTTPESPQLRPQPSKPKLAPVETRDSRPTSKQSHRISPESLPEVVVHPEQRSSSRQQVSQKTTPPDSIHISRPDSPEYRDSLFPSSRAYQASDSAYGSDMERPPVNSIASFDTVSDFPPPPPLMHPGFVSSPHSESGMQFWRPVQASPHSPLQQRPHTSGTQYSVQGQQSPYQSPYQSPQQPLGQLHQIPPRNLPSAMGMSVRSNTTTGTTASQETTGGKSLKKKRSAFGWLKKAFALDEEERAAFEARRQMETRNLYYDGRSAQFLDGKRIQPPLPRQPGPYQSGPYQSQQFQQSGQFPPGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP04</accession>
    <name>A0AAE0JP04_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_584568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686201.1">
        <property type="nucleotide sequence ID" value="XM_062830902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP04"/>
    <dbReference type="GeneID" id="87868056"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12447">
        <property type="entry name" value="RRM1_gar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000550">
        <property type="entry name" value="Nuclear localization sequence binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="167"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="271"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3354823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="416" mass="43849" checksum="A63CABA21FDB4E15" modified="2024-05-29" version="1">MGKKDSVKATKATKVTKAEPVKAAKPVKATKAEKPSKKSKKEESSSEEESESESSEEESSDEESSDEEMTDAPAAKKETKKAESSDSDSDDSESEEEKPAVKEEKKESSDDEEESDSDDSDSDSDSSESEEKSEAEEPSKKRKAEESSEEEEAPKKAKTEEVADDKSTLWVGNLGWGIDDAILLAEFEDCEGAKSARVVTDRESGRSRGFGYVDFATNEQAQKAYDAKSGALLEGREMRLDFAGKDAGNKPQDKAANRAAKHGDTISPESDTLFVGNMPFSADESAVSDFFNSVASVASLRIPTDQESGRPKGFAYVTFNSVEDAKNAFDQLNGSDLQGRPVRLDYAKPRDNNGGGGGGFGGGRGGGRGGGRGGFGGRGGGRGGRGDFGGRGGGRGGGRGGFGGSRGGFQGKKTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP79</accession>
    <name>A0AAE0JP79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_438465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686577.1">
        <property type="nucleotide sequence ID" value="XM_062825371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP79"/>
    <dbReference type="GeneID" id="87862525"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="111" mass="12287" checksum="97B4904D870DF09A" modified="2024-05-29" version="1">MSALQAYRHLMRAARVAFDGDARTLTAAYESISRGFRENQNLPANDPTIAPAIAHAEEVASFLRSNVVQGRKEGESYKLRIHQDTERGDNDTIKLGNQSIKIGEEHKCCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPE4</accession>
    <name>A0AAE0JPE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLUT4 regulating protein TUG-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_33320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686413.1">
        <property type="nucleotide sequence ID" value="XM_062823534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPE4"/>
    <dbReference type="GeneID" id="87860688"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TUG ubiquitin-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="528" mass="57035" checksum="C67057202F43E664" modified="2024-05-29" version="1">MSAHVEVVSTDLRRTKVKVTPGTYLIDVLGEACQKFNLNSDKYQLKHKQKLIDLSGPFRTSGLAPGAKLELVQKSKSAAVVSIALDVNGQRYTKKLSSDMTLWQIMRQFEVAEQGLNLTGRGTPKSSTGPQGTSGQLYFEAPVVNIMGREYTSMEDLQKTLSQCGINSGNIVLRVSFRDTDKTLYEAMQDIGQYLKEVEPDQPKTQAGEPSAPATGSAPAIEEPIEDLTLAAGPKPVKESTLAEPELQVGSAEAAKAAVPVTPAAEPVPKTDPMDIVDEVVAAPPVPPTETTTSELSDPLEPTGVFNAPSSTTPLAARVQVDDSVYEPTIAHAQLRQQQLLQRAQNQRLKSDAELAADAAEEAARLAKITRVDIKVRFPDQTSAQWTVTPEHTGAFLYQAVKGVMAHPDQPFRLILPGTHPIVVVQDGNKRLVADYKLRGRALLNLVWDDAASEEARKSPFLKGSVASRAQEVVVPDVAQEDGEDEKEVQAGPSSSSGQEVKRKGDHGLDSDAVKKKLGKLFKLPGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPF9</accession>
    <name>A0AAE0JPF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_19316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686002.1">
        <property type="nucleotide sequence ID" value="XM_062821678.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87858832"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="606"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="790"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1275"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1343"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1354"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1427"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1494"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1508"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1528"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1561"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1798"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1840"/>
            <end position="1858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3354624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1858" mass="210725" checksum="178E1F17D340B49E" modified="2024-05-29" version="1">MLGLENGDLALANMTNAPDPVAAAEPYAILRQEVELDINFREKSVSGICTFKIYPLVPDLEELVLDTRQCEIDVANITVDGYKTRAQAHDPYDRMEPPTNAQIGATQHHIMKKWMAPLLPETRRQAPIVERAEQLNISVPADGSLRIRLRPDALIQDAEPKRILKLKTAKSVSDNATGLSDPNEEITVVVPFRSKTIRDGLHFVGVEEGDLRYPHVYTRHSLEPGTASCIFPCLDDPGSRHSWTIKITCPRTLGDAFAQPLATQSALSTSLDASRKRKASEISTHQPGSSFTEEDKLREITVVCSGNLTGEQMHPTDEHKKTMIFECVNTAARHIGFAVGPFEHVDLGAEFRTEEADEKLGANAARIHGYCLPGRVEEVRWTCQAVVAAADFFAPEFGRYPYEAYKMCFVEDLVHDTAVANSLSLCSTRLLYPETIIDTDIEVTRKLVHALASQYVGVHIVPNERSDTWLIIGLQWFMTDLFMRTICGNNWYRFHIKSLSDKLVEADVRRPSLHALGDYLHLGDFELEFMALKAPLVLYILDQRMSKIPGSTGVVRVLSQMVSAANISNTDPKATTLSFQDFRRWCEKRSQYVPDELWDQYVFGGGCPRLDIHQKFNKKNLNVDIQILQFQGPTKKSISKDEFWRELQEEIHQVYAGDVPKLFTGPFTVRIHEADGTPYEHYQLITEKDKGGTNLQIAYNTKYKRLKRTKKAMAAAANSNSDKHEIQEDDVVYFNMLGDVLTSQKDMEDWGLQDWAPEVQTKMDQESYEWIRLDANMEWLCFMKTDMQEYMYLAQLQQDRDVVAHQDAMLAFKREKRHAVHSTIETRTVMDRRYYHGVRVMALEDLAKQAHPDLNYIGMVHLILCFRKFFCKKVPIPGKKDAYNYPIAPNDFTDKGQYAIQCAIPAVLARTTDLQEKGRCSKRARQFIMEMLLFNDNSENEFSDQFYIAKLLDALTTSLIPQKEITEGYLIKNLDPFDDDDAEFKSFIEKTIEEIDKFRRMDEWTLTYQNIWTTTALHCKMRLMKARVIPESALDFVQYLQDDNIDLVRIKAFECLVELGMISKPPILKLLLSYMSTDSSPFVRDRLFKVFCRGIAAIAFGENKASTQELEALDDGGLVIDQGDAEIQQRKLDAVRREDITHALNALKEELKGNMEMQISMWKAFNSPVIGLQEKRQLLELCSAMFEPEDSLLVTIKYPIVWKATRDPTIVAAAPPVLGTPPKKRCIIKFKSEYRTVPRSKDVVAIEAPLPPAPLSAPVPSTNLSAARVEIKPPEKKTIVKLQSRPSYIAKPRESPAPEAPPPVRKDSIAVTVPPRPSTTAGPRTPLPTSVPSAPAPNPPVAQPVIKTSVPKAASPPPVPAPKPQQSNDVAAPKPSTVILGKPKIVKPVIKRKSDESLEGASPKKIIKTNNDSFRSDPSRNNSFKTDSPRSESFKKEAPRIETIKGHFSRESAPQIPPSRTSSFSVRPNANGRPSKVVTVPFRKWTKLSARAQRSIDYEQSQREKQMLAASASGISGSLATPVHKRSSAAVGFSSGSAPSSPKSRMQSPAGNGYGSSGSYAEKEQRSKDRERERERDRDREKDSSKFREKDRDSDRERYRGGAEREKEKYRERERDRDSDRERERPREKERDKDKYRERDRDSDRERDRPRDKYREKADRGDSDRGGRTTDSDRERNRGDRDRERERERSDRDRERTDRERERIRDKYRDRADRDSDRESGSSYKDRDRERDRDRDRDRDRDRDRDRGDRDRDRDRDRGDRDRVSSSGSSLLIKKDRKPLPGSGEKERRPLPSGAPGQEREKAPHPLKESHSPIHPTPAATNGAEPKKKIIKLKLKSSGSGLGGGSSSATPGAGGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPJ5</accession>
    <name>A0AAE0JPJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_46869</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686787.1">
        <property type="nucleotide sequence ID" value="XM_062826973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPJ5"/>
    <dbReference type="GeneID" id="87864127"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000013">
        <property type="entry name" value="Probable exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042062441" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="719"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3355409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="819" mass="88382" checksum="B38300DD81E6BFF8" modified="2024-05-29" version="1">MKPLTCSSIPLFACILTAHAFQFPDCSSGPLSNSIACDPTASAPDRAASLVDQLTIDEKLVNLVDRSKGAPRLGLPPYYWWSEGLHGVAGSPGVHFNTTGYPFSYATSFANAINLGATFDDELVYEVGTAISTEARAFANFGFGGLDYWTPNINPYKDPRWGRGAETPGEDPLRIKGYVKALVAGLEGNGTVRKVIATCKHYAAYDLERWRGLTRYEFDAIVSLQDLSEYYLPPFQQCARDSRVGSIMCSYNALNGTPACANTYLMTDILRDHWNWTDHNNYITSDCNAIQDFLPDNHNFSQTPAEAAAAAYIAGTDTVCEVSGWPPYTDVVGAYNQSLLPESVIDTALRRLYEGLVRVGYLDHGSSSNGPFSSPAYDALGWKDVNTPLSQELALRSATEGIVLLKNSNNLLPLSFTGKKVALIGHWANATGTMRGPYSGIPPFYHNPLYAAQQLNLSLSYANGPVMNGSDPDTWTATALAAADKADLVLYFGGTDTTVAAEDLDRESIAWPETQVALMAKLAGLGKPMVVIQLGDQVDDSSLLSNGNVSSILWVGYPGQSGGTAVFDVLTGKKAPAGRLPVTQYPAGYVEEVPLTEMELRPFNHSSSAASSEDDQADIEGDLTIQLERRSTPGNKTLSSPGRTYKWYSRPVLPFGYGLHYTTFNVSLSLSLPASNSLSIPSLLTPCTAAHLDLCPFSPSANFTLFLSITNTGLRTSDYVALLFLSGEFGPKPYPLKTLVSYKRVKDIKPGETVTVSGEEIPVSLGAISRVDGNGNTVLYPGTYRFGVDVDGLLDEEREVVVGLTGEAAVLDEFPQPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPT0</accession>
    <name>A0AAE0JPT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CSN complex subunit 7A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_563706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686536.1">
        <property type="nucleotide sequence ID" value="XM_062830234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPT0"/>
    <dbReference type="GeneID" id="87867388"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="420" mass="44466" checksum="744A36F1B4B61952" modified="2024-05-29" version="1">MEQAKALNALEPFIVLSKSATSPRAAADLVTRATSAPNTFIFTELLQTPQIQSLASSDEFSPYLTLLQVFSHGTYADYTANASTLPTLNDDQKLKLRQLSLLTLVANDGIATSPSDDDAMHQEHEQAQPPNLSYASLIRHLELSSARELEELVISAIYAGLIEGQLDPANEMVQINSVAALRDVPPRGVGGLLSSLQGWAGRCEATLQELEATMANLREEADRRATEEQEWNNKMSQLLEDEQKGAVPSSSSSSLPSSWFNNKRGGGGDGAGAGAGAGGSFRGGGYSRGGGSSQGYRPSQRGNHHQQQNQSRQQQNHHHHHQSNQTGTNSLLTSGGGSYLSFREEPSAVSPSAAAGLMGSSASFAALGGMETGSGSGSGPLGKRGSSDMDDSEENIDDDTMDLDDEGDDSKRGSKRKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ27</accession>
    <name>A0AAE0JQ27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_451858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686773.1">
        <property type="nucleotide sequence ID" value="XM_062826078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ27"/>
    <dbReference type="GeneID" id="87863232"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="431" mass="48342" checksum="63118C8FC13422C8" modified="2024-05-29" version="1">MDQKITREVKAKVEQKIKDLADTQYKAVAHRVDLIYRDSIEPFQTKCLCIEEELAKMREENLKRQQAEEKMREELWGVIRKMQTEIEELKKGRARESVEERFTADAFDSINQNNGTITKTRSRGHIRKDSQPTTEDWAALEAFELSPMSMRGPTSREENVQNYTSSALVPFSSQVDKNTNAPSTKGLGQTGTPGSVVSGLDLTTRPANRGQQSVASLRNTHIADSEPTIPYPKFRAHSNGIILLASDSDDENCSESTASAKRGSTSQFSLRPGRHSQGTGATTTSRSRSPRPSLDASFRVRDDSQSVTKSKSRSTHRRSTSSSSIQSIPNDNDIDLSSQSIPSRFQPSRRTKSANELIDKHLSFIPNGWRTIIANTAKQLSPEDWDRSDARVLKKLEEHCTAFSNLEEILPDVRMAVPALRELMRELGRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ67</accession>
    <name>A0AAE0JQ67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_438917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687085.1">
        <property type="nucleotide sequence ID" value="XM_062825392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ67"/>
    <dbReference type="GeneID" id="87862546"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37683" checksum="C20970C5D4C197CF" modified="2024-05-29" version="1">MPVLNDDVLLRVASFCDIDTIVTMMCTSKHLYELLTRYEQSIVKDAVALYTGGDSSLFPPSGAISSSHNVEREYLYPKRYDILNELKIRTSRTETLLSPGQPLRSKIDSIFSTPGTFLDLPQVERELLMARLKETCKLVDRLGDCAADIMSMWMQPAANGNSSQKLDADEAMLKIHDRQLAYIRSLSPLDLAYLFHLLAWAGQAYAAENPALMADVDCWERLLAFKEASLRQGTIMLWAVFQPPKVKKSANRTEDTTRRKPTTELARFAETCIRQILEEIRIYQSTEPSQNRLPPSLHMTMVKSFVEKTGRPSTRHAIEMERLILEHIRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQH6</accession>
    <name>A0AAE0JQH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_415105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686557.1">
        <property type="nucleotide sequence ID" value="XM_062823963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQH6"/>
    <dbReference type="GeneID" id="87861117"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="357" mass="39706" checksum="87DC08538AA2660C" modified="2024-05-29" version="1">MPVYVSLSSNPRGALILAIFWSILAVCTTFVGLRLYCKIIRGRRLWWDDHLLIAAWALFFTNAAIVTTSVRMGYGLHNNDVPVGNRMLLYILGNITGTTSVLYVLFSKISFAVTLLRLTDGWLKRLIWFIIITLTLCQLSSSITFWLLCNPPEATYDPDIKVKKCWGPTGLLAYSIALGIYSALCDIVLALLPWRILLRFHMYRGEKVGVAVAMSMGVFAGIAGFIKVSTVGKMESDDFSYEGFILVICALVEGACAVMAASIPALRALFIHVFETPEQPSIDVVVDSNRSAGASARRARSDWDERKYENRSDDGILAIPPASSSSMDRSVETDIERDSPRPLSNWFEMQHWKSAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQL9</accession>
    <name>A0AAE0JQL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER protein Pkr1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_414778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687295.1">
        <property type="nucleotide sequence ID" value="XM_062823938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQL9"/>
    <dbReference type="GeneID" id="87861092"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="167" mass="18339" checksum="259930471E6778EC" modified="2024-05-29" version="1">MTSFATNLWESIFTPGPTPTLLIATNVTFAALQIVLACLLFATWSIHFVVLSAICGGLWVSINWFAAELKVHQIQEEEKARRAKEAAPAPVTSEDSETEVEAAKSTASLTRQESIAEAVSHEVEPIQQLGELKHRAVEETPSLGTKSSVSTEDEWEKVSENENEKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQM7</accession>
    <name>A0AAE0JQM7_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_555101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687103.1">
        <property type="nucleotide sequence ID" value="XM_062830012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQM7"/>
    <dbReference type="GeneID" id="87867166"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042194163" evidence="1">
        <location>
            <begin position="20"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="106"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="423"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="584" mass="62625" checksum="2ED7859132BA5443" modified="2024-05-29" version="1">MFGIAALLLLLLATTFATAAPNCPPLGPVFEKPRNFKSSAAIRAALANLTETFQARDADNSAAVRANITSYSLEVFSISDTDPVVFSWHHTAPAHASSNVTNGGVKETDADTVYRLGSLTKIFTVYTWLAQDGDVRWNEPITKYVPELAKAADKAKDDPVGNVAWGEVTVGSLAGQLSGAVRDYGLMGELTQTVDQNTAVQLGFPALNSSDPTLPKCGVWPHCNRTAYTNTGFQILAYALESIKGKPFQTLMEESILHPLNLSHTFYNKAPSNLGIIPGPGTPSDAQWDYQLGDENPAGNMYSSVRDISALGRSIMRSTLLAPVLTNRWLKPAALTSEPNAGVGYPWGIRRIVLSSVTNGKRVVDAYNKAGRIGYYNSLLNLLPDYGVGFSVLLAGPNLPANANFNLADVLGEQLLPALEAAAREQAQDTYGGSYYSNGGGNSSLKITTQPDRPGLGIENWVSNGTDMQYVAVVLAAGYAPVNPSIRLYPTGLETTVIPGEMDRENGRAATKGKRVAYKAVFEDLNVPSRTPPSMFSTDCGSWVSLTGVTYGSMPLDQFFFEVDGSGRVVSIENAALRMVMRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JQW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_454152</name>
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    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687524.1">
        <property type="nucleotide sequence ID" value="XM_062826183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQW2"/>
    <dbReference type="GeneID" id="87863337"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="195" mass="22964" checksum="77A9678DE7097074" modified="2024-05-29" version="1">MPYQNPRPMPHQNPLPYQNPRPMPHQSPVPYWPMPHQNPQGQMPHRGQMPAEPYIPPPPVLDVLQVLEFTPEQLLTHARLLVRTSLWMHAVLSEDDHLASLPEHSKHQLITRFKAFVIQLMTDPRQRLPRSLSFSSYFLDRDRHLVPEDERRRPRSMSFPSYFLARDFDVSWPDMDTHAQTQQGEEPQEEGSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRF5</accession>
    <name>A0AAE0JRF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_505858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687420.1">
        <property type="nucleotide sequence ID" value="XM_062828018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRF5"/>
    <dbReference type="GeneID" id="87865172"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="257"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131716" checksum="3FEA5C9969667C1D" modified="2024-05-29" version="1">MPWSTSTALVFPSAPRQLPPELKLAQAVSEFAQALDGERKRDFMRLQAQCAGSPPTASDVIKMTEELNREGARRHASWTPAAGTRLGGFLSRLQKFAEAGDVLIGGSQSLIASGVWTAVRVSLEAALGHYAYFDQVSSLLMRLTQKWSITLEFAKHFPDSPELQAFLAEYLARVVQLCQKILVVAKRPPYLLLAASILSSFEIEFKPIEDELNHWTDLIKSKFEILANKAAQEQQVAIKDAGRLLRRFHTTRERKRGTPSWILNAPEYKLWKTGTRSVLRVTGHFGCGKTVGLASIISDAIMENKKCAGFICKKDDPNTLDGLTILGSIAHQLLQSSTVRQDWEAMIQRNPSIIVGSMATSSIVQLLQSLLPQNQAFYVVLDGLQECAKQEVEVVLEALHDLRKAHQISVCFSRTLDGLPVELTEEYLGTAAVLSLNNSQRDVEIGHFIRTEVQRRNAVRQPPLNSELENLVIEQLTLGAQGMYLWVSLHLEALFPSHNDGILTDESVLNILNHLPQDLPQAFDQALGRISDLRYGDRIFQLVALNVALTVQPGNNIWNETKLPRSTKQVVARCGGGLLEIDEEDNCVRVVGMDGRRLARSWISDAEAFMGSLDRRVVLLSEALKKEASSYNPILASGDKHRTVAAKQLNIFPILLELKDQKSDEGIMTCFLPYASKYWTQHTAHLTEEDETKIDILWRELVNNRPPHILIPWSQSLDQLADQGGMLEYAISHSHAYLYRLIMRSFPGVNTFLWTGHWALKKASKRENRALWLTEMINRCLVAGSSFVHAAYWFALLLNDVEEEDLKAMKMTPEDSKKYHYALFMGRDFVEITAENATDRLWASVETACSFIPKALDRGDNPRSVCKAIAGALRVLAMRLSLQESTAKENSNSARAAFWRSLEALSRDGDEDTFHTFWNYRLSVVNWGGDAQYLESAMPILRNASKHNNFKLVSKVVASMKSGVELSILEQIVEEVKQQAQSIIRPKLLLGPLMESASYVKDQKPIEGPWLAEVMNYMMNKEYDKVLETIHHIIPSNDGVTNSNLIILNNVVQQERVLRWVITNRYDKVFRKLPFLRQAILYWPTVLLYAITTYAHADAPHDEDAESESIIFFGLLEEMKLIDSKDYCTIGSEDGLDVDPGWTALHAATLWQPFAVKALLETWPDMLGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNQ3</accession>
    <name>A0AAE0MNQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_297193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678693.1">
        <property type="nucleotide sequence ID" value="XM_062823101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNQ3"/>
    <dbReference type="GeneID" id="87860255"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="196"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="835" mass="92099" checksum="77FAC300F3113267" modified="2024-05-29" version="1">MARLGQLTFAISSTGRRSLLARSLTQSSAISRTSARTKPSLLPFQQTRHGFFASGDNKPKSKTRVPRSLSAVLLGSLLVFSLNPTADVLQTFDSTDKTAKTDRSSATDLPAQDVESHGKIDDHGTWSKLVDGFEGFSAMTSAEAGKLSNKLVDLVLPEWSKLIPGYIRKLQRELNMAPGSLAAEIWEEARDPAINPEIQYSAKVRVSEDLCDEEKTFLARRKKITAVALAHYLGIKEEDINPEDVPTIAICGSGGGLRALVAGTGSYMAAAEDGLFDCITYTSGVSGSCWLQSLYFSSLSGGDFQRTINHLKARLGIHIAYPPTAFSALLSAPTNKLLLTAMVEKLKGDPEADFGLVDAYGLLLAARLFIPKGELGVNAHDFKLSHQQEYIRYGQNPMPIYTAVRHEIPELDEAGNEQSHASEAAKAEAKKEAWFQWFEMTPFELFCEEFAAGIPTWAMGRRFQNGVNLPTTEGFYLPEIRLPVLLGIWGSAFCATLSHYYREIRPLIQSLGGFQAVDNLIWGHNEDLSKVHPIDPATIPNFIHGMNGKLPRTVPRLAIESDYIQLMDSGMSNNLPIYPLLRPGRNVDIIVAFDASADIKTDNWLSVVEGYARQRGIKGWPIGAGWPRPSASPSTTAKELKEAEEATEAEADNKLAQAKADQATRHADDPNVKPEGGSDKSLMSQQEKYDQTAHELGYCTVWVGTTQERRTEDPPPPPVDDSSSWKLMEPDAGIAVVYMPFLANEKVPGSVDPASSDYMSTWNFVYTPEQVDQVVALARANYEEGKEKIRATVRAVYERKKKRRLEREKRMAEERQRTRVGLGIEGRLGEGDHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNX3</accession>
    <name>A0AAE0MNX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_246785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678977.1">
        <property type="nucleotide sequence ID" value="XM_062822410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNX3"/>
    <dbReference type="GeneID" id="87859564"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="174" mass="20100" checksum="72291440C8F6AC1B" modified="2024-05-29" version="1">MANAANPKTQITFEEYLGCTEACFEWADSYDTKDFDRLRKCIAPTLRIDYRSFLNKLWEAMPAEEFIKMVSDKKVIGNPLLRTQHFMSGISKWEKVSDTEIIGYHQLRVPHQVYTDSSCTKVAVTGHAHSHNTHYYKKINGVWKFAGLNPDIRWTEGDFDKVFADGREELGEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP24</accession>
    <name>A0AAE0MP24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_296386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678666.1">
        <property type="nucleotide sequence ID" value="XM_062823086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP24"/>
    <dbReference type="GeneID" id="87860240"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000687">
        <property type="entry name" value="54S ribosomal protein L23, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="228" mass="25965" checksum="160ABE1F5E36EDA3" modified="2024-05-29" version="1">MASVAKTGAEALRNAPFRVGKKQIFLPNHVITFVRPLPKQPPNLATFIVPLEFNKLDLRDYLYHVYNVEVTGVRSFVNQRMHEQRHGEVGNWRRPKSQKMMIAELAKPFVWPKPPAEDAREAFDYGTWKKQNTAQEEDRRFKGIRAQGEVVPPSQFEVTKDRKAIKARQSKFLSGEETWAPGKVNSFLNSKIAPEEEGWSEVEENLPLDESAEAAAEESSSKASETKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPK2</accession>
    <name>A0AAE0MPK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_476460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678784.1">
        <property type="nucleotide sequence ID" value="XM_062827364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPK2"/>
    <dbReference type="GeneID" id="87864518"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042071943" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="59" mass="6762" checksum="3804D8073AC9BB24" modified="2024-05-29" version="1">MSALTYLLHLPAFPSILACHNHGGWLATHCRRSRQRLCRRVDWLRELHARAAKQGDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQE1</accession>
    <name>A0AAE0MQE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_528173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679010.1">
        <property type="nucleotide sequence ID" value="XM_062828888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQE1"/>
    <dbReference type="GeneID" id="87866042"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000005">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone]alpha subcomplex assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28012" checksum="54FAE31666CE3F4F" modified="2024-05-29" version="1">MIIPINSMRSTVLRALQRSSAFPLTTPRLVSRSTSFSPSSHITTTTTINNATRRFTTTPLLSAKQKKQKLAHNNEPIPDSPPTTDFGEMDMLGQTPIPSTAIDECFHDGFALNSGVQVTGGSGVLLVGGEVFEWRPWLLPVEGEGNKGMGEKGVVGKEKGREQRRKLVNEKGQWDVPHEEQWGFLGRLWPRPDLLILGVGPSLRPLSPATRALINGMGIRVEVLDTRNAASQYNLLATERGVDQVAAALVPLGWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR43</accession>
    <name>A0AAE0MR43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin-protein ligase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_548364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681182.1">
        <property type="nucleotide sequence ID" value="XM_062829575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR43"/>
    <dbReference type="GeneID" id="87866729"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin-protein ligase N-terminal" evidence="2">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="307" mass="34306" checksum="3EB9AB5D8356C67F" modified="2024-05-29" version="1">MINDVGNLDTMTLKIQVKHKSNWHSEAVRRPRLRIAPTVSFFRPSFSASWRDLRWPWPLIVGTIAAAIDISVKLFDLGQTFTAFPRTLRDIHLRIPTYQYIIDNLTNIGKPPRRIFRDPRTITAMVPSQQTVDNVITIGIDFGTTYSGVAYTWSNKADKVKVITCSLATAKAAPPEFEQNVNNVAIDNSQNTTWQIAVTVALGSIIFMLTVWQVLKKFSGMERSQVDRVSWDSDSYSSSNEEKTPTSLSFGSQTNFLVYAGAGVTPESSRQCTESLKRLVGSNYAVYQIMKSSGATPFQRKHSGNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRJ5</accession>
    <name>A0AAE0MRJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc finger double-stranded RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_540628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680899.1">
        <property type="nucleotide sequence ID" value="XM_062829157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRJ5"/>
    <dbReference type="GeneID" id="87866311"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger double-stranded RNA binding" evidence="8">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3343106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="368" mass="39626" checksum="A9F5C90D270B76CB" modified="2024-05-29" version="1">MADVRALLRQQRAARRIEHPHAAYTDAGKLVCVLCREHIKTEALWDGHIRSTGHRQRLQVLQQQQQQQQQQTEAQDEPTDQPHKRKFDSQDDDEATSPVSTDETDRASKRTRPNTLSPEPGPAPPTSDPADATRPPNLTRQQSFTPTAGIELAIPSRPATPADATTTPKSAGGPLRPFSQLSEQHSQPPTSQPTFTPAPLTTTTTTTTTSAPAPTSADAPQAPQEQVDDDLWASFEADLLAPPSNKPPAAAAALTEGEAVISAAPVSAAEAASAAAKSHDEEQSRRQAAKDVEIEDEREEATRALETEFEGKTSAAAAAVLAALGKENAASGIAAKGKVVEEEEEEEEEEDDDEDEDEDDWDGFRFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRV8</accession>
    <name>A0AAE0MRV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mak10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_588402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681229.1">
        <property type="nucleotide sequence ID" value="XM_062831002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRV8"/>
    <dbReference type="GeneID" id="87868156"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="5">
        <location>
            <begin position="60"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="6">
        <location>
            <begin position="337"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="831"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3344616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="930" mass="103587" checksum="DF7951C91F848E39" modified="2024-05-29" version="1">MIPDYHEAAVQRELLTLSLANNDHNYLYEEPPAPSMSNPGIIATNITKKFLSACKTLETGEIVKDGYFTLFEAVGALEIGDPKMDSGCLAPGETLEETYDVNRPLSAPEVLGIIDQLLCLEMAWHLGYPLSQTILTSVYIEALVEPASATLQEADFVRNRKMPRDPMTTVLRAYCLGLVRTCADVLETIRDELYYEEEDFVTNTYRRNLMDHIDRYEIRDEILSAKHTLHGLRAEIGTDMTQALSFRLELRSAFLRALELIEDRGSPDSLQIPWYQMHSVWEAILKLPGLAKEVPEAFSTKLQRKLASSMPPRPIVTLSFDEAAKHFKKLCNDAIDAVKILDYHDSQSLLNFVFHFQAQKPQPLVYIRCLLQNLLFKDMVLLDRLSIRQVMDDDLSIVVMPAHELLDPNNDLVEAPHSARFAIAHQMELFRKRAAQAYIDIFRVLCQNRCRVRRMFCHLIQDWEQVQLDAEDIDQLLQIQIDEKPLAYQSQTTLTLGSEPGYSLPLSSWAYLYKLRLMEWIVQLGFELEVYAPDELAGMYWYLSHLAKTRAQHVERIQAFTNHRFNELRSSSSSTSPPSSSSVVSPSSPSSSTLGLTHAHPPPPSSYTKPIPATPWIPPTQPYHPPRGWPVSISPSISSPSAPSGPSGAGAGPTTHHYSTTPEASFTRSLTYLRSTILDAAITWEFADTVSLIYTILSRLSLISPPPRPYGTDEHRYEVRMKPFRAVSLPEVPGFETWKGCTATATAQAAQQGRDWDGGEGGEEKTGSLLGFAVQAVGQAKKAFGVLEGLGEREAFSGGGGGGGGGGVFFGGQFESAPTVTTGVAATATEAGGDGVKQGQGQGQKPQEPGRGGHKRWMENVRRYRRSVEKAERILEGGIRKAVEMDAEGRTTEEIKKVVEVRVPRSEKVWEQGGHWWWIVPDVEVVEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSC2</accession>
    <name>A0AAE0MSC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_525483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682116.1">
        <property type="nucleotide sequence ID" value="XM_062828833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSC2"/>
    <dbReference type="GeneID" id="87865987"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="424" mass="44035" checksum="CA3A4C938BB26997" modified="2024-05-29" version="1">MRILSAAHDIKNPAFNNIPFKRATSVVPEQCSNFCRNAQLECQQNPLTPALCGTGSNFLDQYYQCQSCIQDNSRNPELIKASLAMRFMKCVGYCKLQAAGAPSSESQTGSPGPATGQNEDPFTTATATAIPTEKTSSTSSSFAVQTMVSTSASASMDKGERTMVTSTLPAPTKPTSPPPPTNNPPAVSPITSTSTPQSLSTLPSSSSSSFSSTSPSTSLTTLNPTTKTQGQATSTPPHALTSPTDTSSTSTPQPNANLNPGATKTAPWVWAIVGITITVVLLLSGGSFFVFYKRGRSKRGRARQRQRGMKGMVELKETATKGFVDGRGSRASSRGQGIGGVAELDTVREVYEVGTEAESARGGGREGRGGGREGGGGGGARPAGNADGTLHVLPVELSSVSGVVELPTSFNEREERRSGQGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSK9</accession>
    <name>A0AAE0MSK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_538340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682697.1">
        <property type="nucleotide sequence ID" value="XM_062829086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSK9"/>
    <dbReference type="GeneID" id="87866240"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="234" mass="23402" checksum="2EC51321F2C9B486" modified="2024-05-29" version="1">MLHLSCCVEHVECEETCVGAFGMAQTQPGLSGQIPGLGLGQGSGLGQASGIGAAQGHNARSMMHQQQQMQQQQPGIWNAASAHAHGQAPLAGPATGSGAGLARPSGPGPGGGQGQGMEDVVMGDQPSHQGQGFNIDPRLGAGSNAPAGFQHASFARQPPRPNAPHLPSPLPGQFGGPPTTLYNVPDWSPVDPGGLTRARSRTMGMGQVKGLMAMVEGGPDTPGSSGPSTSQAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MST1</accession>
    <name>A0AAE0MST1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF167-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_150017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682566.1">
        <property type="nucleotide sequence ID" value="XM_062821068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MST1"/>
    <dbReference type="GeneID" id="87858222"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13732" checksum="FCF87041530B6FEB" modified="2024-05-29" version="1">MSTQRALWFVASKATKKSSPQGTQAGTIYIHCKVKPGASKTREGVIFITDEAVEICVAAQAKEGEANKAVVKVLSEALNLPKSNLEITQGLKSRAKTIAVAAPGSWVGGNGGEEECLERVKAYLNKATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSY7</accession>
    <name>A0AAE0MSY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1168-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_195080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681710.1">
        <property type="nucleotide sequence ID" value="XM_062821703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSY7"/>
    <dbReference type="GeneID" id="87858857"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="25256" checksum="04ED9E61938AC881" modified="2024-05-29" version="1">MSADDPSSIPTSTSRLSSRPTKRLRASSPTSLQASHLQQLFAKPDREIIIPPLPSSSSTSSSSRLPPPPEIVTNVQGSSAGAGSGEFHVYKAARRREYERLRIMDEEVAKEREREEFEAKKSERERADEEKTRRNREKREKKKNKGKGGKGGGGGGNGGGGGGSGNAATVTAAAENGAGKKETKKEEDGGVKESTTGAGASTKDTTGEKAAKEADKSSSTAVAAAAPKSANGESGLLIVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSZ4</accession>
    <name>A0AAE0MSZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_213614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682384.1">
        <property type="nucleotide sequence ID" value="XM_062821967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSZ4"/>
    <dbReference type="GeneID" id="87859121"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="193" mass="21444" checksum="852CFDD00112D082" modified="2024-05-29" version="1">MAMLEPPEVMMRSCPNTSIPRLFKGLILSLELTVTLTKGACITVQIEVGQVVTTKTDDESAGRQEGVEVSRFNKMWMCNIYSGTVNSSPSRYTALQIWTMTASPSMNNHYLIWMICSIIAALLAVTSDTLSGKWNRVSLRTNDNNQHDTGVPSRGMGKGITHHREEVDRQRFGQINSSSPSWRAGSAVSMHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTS7</accession>
    <name>A0AAE0MTS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_455602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683987.1">
        <property type="nucleotide sequence ID" value="XM_062826243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTS7"/>
    <dbReference type="GeneID" id="87863397"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.390.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041964508" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="406"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3350692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113181" checksum="B407193485A63794" modified="2024-05-29" version="1">MRFVNRALGSPACALLLLSSGLQYVLGASDTSSAWPIQGNDLQNQIQWDHYSIIINGERLFLFGGEMHPFRLPVPELWEDVLQKVKAMGMRMISIYTHWGFHAPTPDQVDFDTGAHNLTRFFEMAKEVGLYVLVRPGPYINGELNAGGMALWSTTGAYGELRSNGSAFTEAWTPYQTGMAKLVKPFQLTEGGTVIMYQLENEYGEQWKNVEVKIPNPKAVSYMEKLKENAIENGIVVPSVHNAPNANGRPWSKDYDTVGAGGDVDIYGLDSYPQCWSCVTEECGNNILPFAVSNYHDHFQLVSPNQPSFMPEFQGGAMSPWLSPAGGCAERTGTEFVNFYYRDNIAQRITILNLYMIYGGTNWGWLAAPFLGSSYDYGAAISEDRNIGSKYYEIKNLGLFIRAADELAYTDRLGTGTNYTNNTNIFTTELRNPKTDARFYVLRHATTSSSSEETFAINVTTSVGSFYVPRVAPCPKLVGHEGKIFVADFHFGKHSLYYATTEVLTYSVIDGKTTLVLWTPVGISGEFYLKGAKKGTLASSSRGQTAVFDKRDKGVVVGFTQHEGATVLDFDNDVRVMLVDRETAYQTWVPALTKDPKVPVDKTAIVVGPHLVRSASVQGNTISVTGDSNNATDIEVFTSNRVSTIKWNGKQLQTTKTKYGTLKASLQAPVKFSVPKFGSWKSQDSLPEKAVGYSDNGPAWVIANHTTTPSATKGTVPYLFSDEYGFHTGIKLWRGHFSGEAAATGVYLNIQGGTAHSWSAFLNGQFLGSYTGDPTVTASNATLSFANATIFTNQTNVLFVMNDDTGHDQLSAALNPRGILNVTLLSSSSSPPPKFTLWKLAGTAGGSDTNRSTLDPIRTHYNEGGLTAERLGWHLPGFDDSNWSNTSTSPAQGFTGPTVRFYRTSLPLDAPKGLDASFAFKFTPVDTSNLNYRAFLYVNGYQYGRYYPSIASENVFPVPAGVLNHGGENVIGLAVWAQTEEGAKVDVELVTRYAVESSFESRFDGKYLQPGWTAERLAYVKFQDIRYHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU71</accession>
    <name>A0AAE0MU71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-aminocyclopropane-1-carboxylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_94945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16933"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="EC" id="3.5.99.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683946.1">
        <property type="nucleotide sequence ID" value="XM_062831597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU71"/>
    <dbReference type="GeneID" id="87868751"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009310">
        <property type="term" value="P:amine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06449">
        <property type="entry name" value="ACCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005965">
        <property type="entry name" value="ACP_carboxylate_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01274">
        <property type="entry name" value="ACC_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="362" mass="39242" checksum="B4D1E59CF7D48533" modified="2024-05-29" version="1">MADLLLPEPFASIPREPLTFGPSPIQPLPRISQALGGQVNVFAKREDLNSGLAFGGNKTRKLEYLLPDALSQGCDTLVSIGGIQSNHTRQVAAAASKLGLHAALVQEHWVPDWTDPGYDKVGNIQLSRLMGADVRLEALVGFGIEHKQTLAKLKDDLEKEGRKPYYIPAGASDHPLGGLGFARWAFEVVAQEEELGVYFDTVVVCAVTGSTMAGMVAGFRLLEKLERDSEKLGEEAKKRRRRVIGIDASAKVEQTRAQVLRIAKQTAAKIGLSEEDITEEDVVLDDRYHAGVYGVPDERTIEAIKFGARTEAFITDPVYEGKSLAGMMDMIKNGEIEAGSNVLYAHLGGQLALNAYSALGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUC1</accession>
    <name>A0AAE0MUC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_545686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683869.1">
        <property type="nucleotide sequence ID" value="XM_062829402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUC1"/>
    <dbReference type="GeneID" id="87866556"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="416"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="648"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="915" mass="102463" checksum="A3DB818B5CFD75B0" modified="2024-05-29" version="1">MKGTQPHQQPPLPPLPAPPPHRLSSTSVVSAPLPLIPVPLPLTHPNLNRNRTSTSTSRIRHHSHHINNYHCHPWPPISASRQDQYRIPILGTPTIVTHHLSGSIDDRVYAQHLDPYHPHSRSSSAASTPSGTSTSGFGAPPRPASRSGGSSYHADHTHHTNHTPAQYQHQAQHQYQHQNQQHQHQLQQQPHRQPDQIHPVYSHFPVPNPGCGSYFSKLHFAGYHLGEISSYNGIPFFSEDGQAWIRSRTGQHASFPAIWGDVPPWQTRPSVDSVFLGKVAEKPIGQLELPDRKVVEQYFSFFISSEFRLSFPLVDPVLFKQTMDVAYEHGERVTNGLGFEQITAKACVFAFLSVISLLEAERTERFPDIPSIDTDMMAAKAQMLLPLTIPALDITSLQTSFMLCLYQLFLGQVQSSAMLLAFACRIMFMLGGHKLSNDSWLPTPESRSGSGTTTPASAPVDIADRKRRHLRKLFWLCYYVDTDISLRTGQPPSIDDDHCDLSLPPGYIEIQYLDRRELEALKERHFYPLNSYPNMPSPSPYPYNQGAGQSGPNPSKPSGTPTTMTSAAQGHRIRHPYLGHSYPGLDETSVPVLPGDLRLTLIKSKTCKLLYSALALRKSDAELLRDIRELDDELERWRLSVPERYRPALSLPRTSPPGGLQRAQGQEGSQKGSGGGCYFQVPGRKQEQEQEQGQGQGQKQGHGYGKSYDHTMSAESVRTILINLQYHHLVATIHQATGRCRAWQNRSSMLEENTNARTGEMLMEGVSSSLALSVEASRSTLIYLRSVTRALLGEAFWVIILYPMSAVMTIFCSILLNPLDPQAEDDLRLLESAPDLIKGIRIRRPTQTELLHLKTVDEFMGELMRLGGCAIRRAREEQKEREREREREMQRGIGGMGYRLPELSEASGGEGWRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUC3</accession>
    <name>A0AAE0MUC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_113773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684602.1">
        <property type="nucleotide sequence ID" value="XM_062820622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUC3"/>
    <dbReference type="GeneID" id="87857776"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="503" mass="54091" checksum="E682D522548C58B0" modified="2024-05-29" version="1">MVRNIVVLSGSSHPKFVDSVCEYLGIPPASRVLEKFSSGETRCEIRDSIRGKDVYIIQSFGVGTDRNAANNNNNTDGSSSTSATAGTGHVTVNDYFIELCIMISACKTGSARRVTAVLPFFPYSRQPDLPYTRTGTPLVSRNRDAAAMTATEGQGGVSYTFESVPPTPAAHIPRTAGLTNGVSKLVNGLSNSSITRGIDIRDMVKAPATVTVTGPASDDGNNSLGEKQPQQQKANDKFTTHDYENPTMAMAFQQKAGFKPMMAQAGSLIADLLTCAGADRIVTCDLHESTYQGFFDIPVDNLIAKPLLKRYIQHHIENYKEAVIVSPDAGGAKRAAAIADSLGLQFALIHKERRPPSKTHTNYPTMMLVGNVANRICILVDDLADTANTITRAAKLLKREGAVQVIALITHGVFSGDAIQRINASALDRVVVTNTVAQDRHLEAFRAAGAGGKKELPDKNKNDVDPRVVCGKLEVLDIAPFFAEAIRRIVFGESISMLVRDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV15</accession>
    <name>A0AAE0MV15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_538027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685353.1">
        <property type="nucleotide sequence ID" value="XM_062829082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV15"/>
    <dbReference type="GeneID" id="87866236"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="296" mass="30892" checksum="111E2224D0EE03E6" modified="2024-05-29" version="1">MAITKSISPNHHQLLEVRALGPPFTGFAHSLGRSITGTPFQKRDFSHSSETLPGGSEAGVCHSTLSTVITDVTLQPYDNDLPEQDTARTPILRVKEGPSANLPIVMTSALGLSIGGHPDGTDVDKRIGRDSSQHHPPDRLLLAASTAALPTPPSSTSNSLSATDPDCGRSGYNCGDPEPSGTAVSITGSGRSGYNKAREAEQSADTDGRSGYNKRTPGGRSGYNDIGEDDGTVSATGGRSGYNKAREQSADTDGRSGYNKVRDQQADTDGRSGYNKRTPGSGRSGYNNVEDGADGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVS2</accession>
    <name>A0AAE0MVS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_459853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685354.1">
        <property type="nucleotide sequence ID" value="XM_062826487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVS2"/>
    <dbReference type="GeneID" id="87863641"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="645" mass="72610" checksum="3CDB845FC78091B4" modified="2024-05-29" version="1">MMLFSVPVAVSSTSIRYNDALDILNFLTTQSLLITMPTTPIANPNAAIATSDSSTTMSDSLAPITQLAATMPQIAGNSFGNRAGNPPSCPVDHPPMERMSNEILTKICDMAVTEEKRACGARALALTSKTMQPSARRAMYNSIVLGDYKKSILLLRSLLQFPHNRELVRHLEVRPPVKIPHPDGPEQPRFVDMSKVLDTIYRGERCNPQLPPALLDDLKEELDPFPTETEWSFGEYPQGGYNTVTRAIIFLCQNIQSFKVQIMGEWSGSSCYYTRTQPRFLLAWARRRHPAIAFNHLRILDLDVASIACFSRTPKFLGDKSMCACRVTCPPTVEDLTLRHEDASLSRNFLPPDHFNDSFDSEDYEDDDDDDDDQHSLLPNIASCLDGLLYFLMPCSASLRKLRLLGGFDHSGLMEPSRLFTAQAVCENNWNTILPHFQQLVHLEFSGYGNPCPPDDGHRNTWPDNVYRYGTDKTISCLGQLPKLRYLKLPLVDLFPLSPAAFPDTAKGLRELVREELPGELDPDDVLYDPYVPLFHCRAFKRTMIQSMKGLAGPLGTGKGTHHNVGEKLRQAAGGKEIPRNLEKVEVYYFVKDADKKKDPRERWAKSSQYVSLDRAEIEAHEARMAEEAGWFPTKVKTFTWTRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW79</accession>
    <name>A0AAE0MW79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_16418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685909.1">
        <property type="nucleotide sequence ID" value="XM_062821279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW79"/>
    <dbReference type="GeneID" id="87858433"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3354531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="346" mass="38364" checksum="653942628053C5B5" modified="2024-05-29" version="1">MNFLRSTAATLLDKYTPVSHTSTFRNTGQITPEEFVAAGDYLTFKFPSWSWADADSPSKRLPFLPPGKQFLVTRHVPCHRRLNDDFAGDAGHEEALVEGNKGGADDDGWLRTGSMTSSQPLRVREVRNIDDAGNVGDREVVDEDDIPDMEDDDDDEAIIRAEGDNSNSGKRTYTLYITYANAYKCPRMYMSGYLANGQPLPPHLMMEDIVGDYKDKTVTLEDFPFFSHSVKMASVHPCRHASVMKTLLDRADAALKLRREKMKAGQVSGSEQGMEGLVDEINKLDVSGAHANAVEAAPGEDAEWEEVPHDVADQEVAIRVDQYLVVFLKFIASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWN0</accession>
    <name>A0AAE0MWN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_53010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686988.1">
        <property type="nucleotide sequence ID" value="XM_062828919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWN0"/>
    <dbReference type="GeneID" id="87866073"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="4"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="414" mass="46247" checksum="0D7BC4E599DA89FA" modified="2024-05-29" version="1">MSSAIVLGATGITGREMVKELAAHPSQWKTIHALSRSKKEDFGSPSVQQHHIDLLNSAQDMAKDLSSIPDLKAVEHVFFCAWLQMPTEKENADVNGAMLQNFLDALEITGATSKLKRIVLVTGCKQYGVHLGQAKNPMLESDPWLRDESRWPPNFYYRQQDILTAFCGEGSKHPEISWTVTYPNDVIGYAAGNFMNLSTDVGIYAAVNKELGRDLEFPGSEIFYTKFDSFTSSKLHAQFCVWAVQEPKTANQAYNVSNGDVQSWQDLWPRVAKHFGMKVKADQFASPGPKDLANLVQLTEKAPQPITMIAKEIGLEGAVPPSELKQRISLVKWSKTEEVKQAWNRLAEREGLQKDSLEKATWAFTDFILGRNYDVVISMSKAREAGWTGYIDTWKSLSDTFGELEAAAILPKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWN9</accession>
    <name>A0AAE0MWN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_54105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687018.1">
        <property type="nucleotide sequence ID" value="XM_062829167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWN9"/>
    <dbReference type="GeneID" id="87866321"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14076">
        <property type="entry name" value="STKc_Kin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034674">
        <property type="entry name" value="STK_Kin4/ppk1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="304"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1088"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="690"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="849"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1109"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3355640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1146" mass="124933" checksum="937F2055B9AE57F6" modified="2024-05-29" version="1">MSTAFQTTPNQSISVSATTSPSNRQYSSFHPDPPTTREGPGSGYYANQHNAGQSSSHTSSQQHSRRPSAYDQPTGFEPHMSSRTAIAQSVPAPVTSIASDQPPSSSDRRRNNMPTAVPPRTSSRHDPNTSSRRATQSADRAAASRQSNANGTMDPAAVDEAAARSRRQHQMAQDANHRTSSSRGNPTATSLPVRSQPNATSSRQQSSREASDILNNILIQQPEIDIERERERLAQAQAQAHAHAQAQAQAQAQQASNYNHHHRQEAASQAVAAPEGDYGEESRRGHRSRHDHSKREKHTKFGEYILGNTIGEGEFGKVKLGWKQEGGVQVAIKLIKKDTVGNNPSRMAKIMREVAILKQLTHPNIVRLHKMEESDRHYGIVLEYASGGELFDYILNHRYLKDNAARRLFAQLVSGVGYLHKKGIVHRDLKLENLLLDRNRNIIITDFGFANTFDPNQELSEEEELNLSDREFVKRMGLDKVNDAGWRKGDLMQTSCGSPCYAAPELVVSDSLYTGRKVDVWSCGVILYAMLAGYLPFDDDPANPEGDNINLLYKYIVNTPLTFPEYVTPHARDLLRRILVPNPRKRADLFEVARHSWLSEYSHVVEFITSSTTTPSEIQNTTVPAEDEGEPPHLARSASVREAPKKPTASPAIGGLVSKQGTVDPEAEAAHAKQQRDNKRRTVQVEYVAPNTTTQRGDTAGQQQPSSNANRNRNESQAPVESSGSIPTTSAKDKQLSQGPSAPKDAYNNKPPVSSRRPPSSQQNAGIAPTTGNAAAPRPSRDGRPTTTENQYLSGAAGALTQRPTTGGSMQSGRPSYGQPAPPEVADANVHGRIQQPFKGSGSGHFGVPTSTPAEQQPNQSVDSYGRPSISTGSRFDKVREDGVVKGHKRSSTMGELGGKLFGRSGSLFGGRKSKRQQELQQAGEKTKKYPPVSMNNSMPGGDNGSRPSLDSKRSRRSFSMGMGKKSSGGSITGSNGSQEKSNKRFSFIPPSLSRALGYNKEDEPPALDSQQDLPIQEPSSVDQFVGREQNVSATTVDGMYTQLQDSQQGLPAANTQYQYGRPSGTMLNAGSDPSVNSMPRAPVQQDGLYDARKGNNRANRGVLQKNKRFVDYEGGPHDHSGSSGPARKVMDFFRRRGKARGGENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWP1</accession>
    <name>A0AAE0MWP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_544423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686526.1">
        <property type="nucleotide sequence ID" value="XM_062829291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWP1"/>
    <dbReference type="GeneID" id="87866445"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31421" checksum="6B61063DA37ABE01" modified="2024-05-29" version="1">MSFIPVSPPPTPSGPANPGTLAPSALIATLSALLSPQTGSLTHLVQSLSVLLSASASGASLSLSFFLVPRLLESPTPLMLTQWRRVYEQTFSTLNRAGAAAALGYFLLAWRFGVRYTSEVVKGGGLQGLKLVKRGRMYAVAGALLVLGMAPYGWVVLGGVERRLVARAEAVERAMRQKGVDVEVGELGAGGNGGGLSRKHSVRRKNSTKERGGEREREKGKEREKEKEREREAEEDQDSSRDGDVEAGLGEKVDMKAVEVGAKYWVDEWGVLNLGRAAMIAASAVMGLSASLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX25</accession>
    <name>A0AAE0MX25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mate-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_48652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686839.1">
        <property type="nucleotide sequence ID" value="XM_062827691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX25"/>
    <dbReference type="GeneID" id="87864845"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="667" mass="73552" checksum="1A3EB636E5EFF6A6" modified="2024-05-29" version="1">MASPPMPIQLSGRRRGSAARRESRDFHETLLDTVSLLGTSYLSTAPIAQEILARDLAELEDDEQHERDEECRSDDEEDLEPPIDVGSLPVGAHLVSRPGGIAYGTLRPIIASEMQGSPIVCETDVVESRAAERSLLRDNHLLPPKHPRSPNDPLWKKIYRRLFSTKVPVSDKLFEETPLLQEYPLPPSPTISEEINQWERAVAQNMLKTTWQREAQTITKYSRSLIVTFLLHYSVTVTSVFTVGRIGRLELGAVSLATMTANITCYAPVQGLSTCLDTLCAQAFGSGHKKLVGLQLQRMTYLLWLLLLPIATLWWFSGGVLNRIIPDPDTAALAGMYLRVLILGTPGVAAFESGKRFVQAQGLFHATTFVLLIGAPLNVLANWFFVWRMGWGFTGAASAVVFTQNLLPFLLFLYVRFVQGMECWNGLSRHAFSNWGPMIRLALPGMIMVEAQYFAFEVLTLAASQFGSAHLAAQSVLVTVTSTTFNIPFPLSIAASTRVANLIGAKLSDAARTSAKVALCCGIVVGLFNMTLLSTLRFKIPYLFTNDQEVAAIVSKVLPICAALQMVDALAAISHGLLRGIGRQGIGGFTNLFSYYLIALPISFSTGWALGWKLQGLWFGVSIGLAVVSTVELWYLHQADWEHAVQEAENRLRSDEACHQSQRRESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX36</accession>
    <name>A0AAE0MX36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_452430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686946.1">
        <property type="nucleotide sequence ID" value="XM_062826098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX36"/>
    <dbReference type="GeneID" id="87863252"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075306">
        <property type="term" value="P:regulation of conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN TMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57933" checksum="AAFA177086A00252" modified="2024-05-29" version="1">MEDKPYTSPVEEKPESAGITVTIETTTTPNSGKKFGHTRQNDSVSSTFSQASAISTSSTNSEKPLIVNEKRLTYQSTCPTIVDLEAQTEEDEYKQKPLGRVRYTILTIYRRLFTVAFMGNAIAFIIMMIKGAHPMDLVNAAAVNIAVCGLCRQPLVINALFLIFGSIPRSAPIRIRRLACKIFHFGGVHSGTGVASVVWYIGFAAVFTYNYTPSVINTTVLTFVWAVLGFLLSIVIVAYPTFRMRLHDYFELTHRFANWIILVLFWILLILLGKQQADLGNFLLHLPAFWIIIVLTLATIHPWLLLRKIPVKPEALSPHAIRLHFSHTEVVFGQGISVAKHPLKDWHSFACFTDKFDTPDTKFSCIVSKVGDWTKSTINDQPTHLWKRGVPTYGFGYVLRMFPKIIVVTTGSGIGPCLSFIEDANRPDMRVIWQTKSPLKTYGQRTLDLVHRMDNNPVILDTSITGRVDMLPIVLRLFKEFNAEAVCCISNPMMTKKIVHGCEMRGIPAYGPIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0B0</accession>
    <name>A0AAE0J0B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_437026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <position position="1"/>
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            <dbReference type="EMBL" id="KAK3334613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 560.94</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
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<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677232.1">
        <property type="nucleotide sequence ID" value="XM_062823643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J198"/>
    <dbReference type="GeneID" id="87860797"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3335066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="696" mass="74546" checksum="8E8BF87BADBC1BE4" modified="2024-05-29" version="1">MAGETAPALNQGVGYGIVIGLGALFALGMILVTFILKRYNRELQTSEMFNTAGRTVKSGLVGSAVVSSWTWAATLLQSSGVCYRYGVSGPLWYASGATVQILLFATLAIELKRRAPNAHTYLEVIRARFGTLPHMVFMIFGLMTNILVSLMLIVGGSATINALTGMHTIAAIYLLPVGVVAYTLVGGLKATILTDWIHTFVLLIIIIVFSLTAYASSDVLGSPSAVYDLLVKAAAAHPVEGNHEGSYLTMRSREGAIFFVINIVGNFGTVFLDNGYYNKAIAASPVHALPGYILGGLCWFAIPWLTATTMGLSGLALENHPSFPTYPNRMSDADVSAGLVLPYAAVALLGKGGAAATLLIVFMAVTSATSSQLVAVSSIVVYDLYRTYIKPEASGKRLIYMSHVAVCAYALFIASFSVGLWYAGISMGYLYVMMGVIISSAVLPAALALTWSGLNKWAAALSPVLGLCVALVAWLVTAKHECGEMSVECTGSNMPMLAGNVAALLSPVVFIPVLTLIFGKANYDWKSMMAISRGDDHDVAGEAGVDLEEVLGGREESEREMEEEQKKLRRASKISKSMTAVLTLALLILWPMPLYGTGYIFSKPFFTGWVVVGIIWIFCSFIGVGLFPVYEGRETLIRTCKYIWWDITGKKGVKAIHAEQAAHAGEVVVTEGMTPGDQTPTEEKSLKEKGEKVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1A0</accession>
    <name>A0AAE0J1A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_341324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677244.1">
        <property type="nucleotide sequence ID" value="XM_062823648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1A0"/>
    <dbReference type="GeneID" id="87860802"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3335078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="228" mass="25001" checksum="546BAD755DB95BD6" modified="2024-05-29" version="1">MPAVTAVTAMIATPTTSLSTATPVFRPPPSLTTVTHTVTPPAAIRNDGYFCPSALWAYHASKTPDQLGLPEICPWARATLPFDGLCSHAAFDEGVNFGHDEHDSTGMTEHDIRELEASAEERRQAYLKRHREHNSGFRNRYLAKEDFVLKHTVSEPKVTPPQSCCRSCVAYATPLQPSSHGRHVPESVRRSMVLFLRAGIVNGIVCILTTSYMHNTATVCTGQMVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6Q8</accession>
    <name>A0AAE0J6Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_308237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677395.1">
        <property type="nucleotide sequence ID" value="XM_062823253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6Q8"/>
    <dbReference type="GeneID" id="87860407"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3337944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="334" mass="35091" checksum="272C5B9FEA7504C9" modified="2024-05-29" version="1">MVPLLQKTDPVFALVVRGEFEEFEKVEELEPKEERATSKGFFVPRVERALRAEMVPLLQKTDPVFAPVVKGEPEEPEKVDEPEEPKQERAASEGLFVAPDAAANEADPFADDHDTTMVDASIVDTSVVDASMVDAPPPSSAPTATSTIKAEPVESVLLQSGNQASVPAVTNDHASLVQPAVETTPAPAVAAPQAVAAPQAVAPTEAIQPGTAAPEAAQAVGVAHERARAATAGPEAVGTANVVPQPPRAATAGPDPISNIKREPLEDHSLLTSFCSERNPNSDDEEEDSTATEGEDDEGDEDEDDDNAESSSDEDSSRAPSVDMDLVKPEPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6U8</accession>
    <name>A0AAE0J6U8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_310148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677455.1">
        <property type="nucleotide sequence ID" value="XM_062823282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6U8"/>
    <dbReference type="GeneID" id="87860436"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="403" mass="45151" checksum="DE3FC9C4BD1FBAF8" modified="2024-05-29" version="1">MFFKTKPLGSLKSILPPIHQPLPLNQRESQKLLDVLKASFRAHLDKEHGWTPDTNQVAPAAPTVTYLPSASPASSKDVPARPTDKHMRAILENPLFNNKAFVPPSVAAPAPAVRNNRNDIFQLAVSKGIMNTQRALGFLLAVQRDIQLSAAVSVTQSMKESGAGLLVLRWLRSSGKERSLGFLGNRTFTRLLLRYMVAEGLDELAWSWFQRLLNEPALTTGNPERAAHPAVLLDSLIMAKSQAIELDEAYTSMLRGKEVIDDTSASAQHLMHAWRRLCWHTTGQSYKHQIPPASLFESFAAVHNEFRKPLPMAMAHLALYHPTNPSPNLALEYLSNEYVWNTRLPNYKPDNPEAKYITKLASLMLDTIQNLMQSGRFTEAQRLMERFRTHLAPMGPHLEAIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J715</accession>
    <name>A0AAE0J715_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase-like protein SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_560954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677520.1">
        <property type="nucleotide sequence ID" value="XM_062830157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J715"/>
    <dbReference type="GeneID" id="87867311"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="303" mass="32717" checksum="BAE6A9C9A665CBF2" modified="2024-05-29" version="1">MGSTQKGYHLPADAPPLVTDTLTVTGCSQGIGRALCTLVLSKGHRLVATARNPTTGLSYLPESTPSSQLLKLPLDVTSRSSIDAALDASIAHFGRLDVIVNNAGMFIYGNTENTDEADGRAVFETNFWGPMTITQRAVGIMRDVNPKSPSCDGAQGGVILNVTSFGGRVAVAGSAFYDASKVGLEAFTECMAQEVKPEWNIHLSCIQPGGVRTGFISGRKRIDEHPAYKGFEGTLQIVERYFDDPQTPESWNTPESMAEGIYETVSSDKEIPRRVPLGHDAWTVLMADHERTGRELEAGKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7G3</accession>
    <name>A0AAE0J7G3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_309367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677431.1">
        <property type="nucleotide sequence ID" value="XM_062823269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7G3"/>
    <dbReference type="GeneID" id="87860423"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03816">
        <property type="entry name" value="GT33_ALG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000162">
        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3337980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="458" mass="50065" checksum="B438618D19B89A77" modified="2024-05-29" version="1">MASILVALVGPLVLTGLALLVTYLVLGPSKYGGPSSGKGVVVHVLVLGDIGRSPRMTYHALSIAKHGGKVNLIGYLETPPHPSLLSSPSITIHPLPPPPVRPPSVPFLLFAPFKVLHQLFCLFTLLAYTLPPSQWLLVQNPPSIPTLFIAALVCRLRGGSTKLLIDWHNYGWTILSSTRGPRHPLVYIAKLYECLFGRLGDHNLTVTHAMARQLRKPPYNIRGPMTAVHDRPADIFKPMWWGKARQEVLERVLPAEQRELVPSIMEGNTKLIVSSTSWTPDENFGILLDALVAYAADPVSEETPVLAVITGKGPQKEMYLRQIEELTGSGQLPNVRIVTAFLPFEDYAKLLACADLGVCLHMSSSGVDLPMKVVDMFGAGLPVAAYCGYESFGELVKEGVNGRGFERYGELAIILTTLLSPEGSGELEVLRKGAVSEGRRRWDEEWDEKVAKIMGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7P9</accession>
    <name>A0AAE0J7P9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_324163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677933.1">
        <property type="nucleotide sequence ID" value="XM_062823450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7P9"/>
    <dbReference type="GeneID" id="87860604"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="261"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3338482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="653" mass="73459" checksum="9A214C4A1458A1F5" modified="2024-05-29" version="1">MPGIRSDANTPQPDREYISDEAHLLPLPPDAPDLHELNASLDALSSVFPDIQIDVFREMLSSFDGESRLALVANALIQNKVTWVKGRWRAAEKEKMPRHVPATAEPGPGPLPVVSVPSRHKFRSKEYRSAVERLAWQEFKGLSRSTITAVLAENNYWYPDARPTLVSLSSKSWRFAISSLFLRRKSVSGTEAATHPLVIWKSSGRGSIVPCIKTTCNAELDKELYEALIVPILQQARQEREDKDHTLAAELNTQEAEELESMFECSCCFTEATFEELVACNIDGHTICFRCVHHTLSEAVFGQGWQSTINTETGTLRCPAVEGSGCKGCISQEQMHRAMLEFKKGAGIMHKFEQRLAEHSLVTSGLPLARCPFCSYAEVNEIYEPPNPLTHHSPRKSAFQLIFVVLCIGFMPFILPLVVIIAIITVLLSYKQDIAIPLSKEYHAARQRLHRRRRGSKFTCRNPECQRNSCLSCNKEWIDIHVCNESSLVALRTQVEQAMSMAVKRVCPRCNTSFVKTAGCNKLTCPCGYKMCYVCRKDIGGDGDGPDVGYRHFCDHFRPEGDGSKCDKCTKCNLWEAENTELVLKQAKEEAERKWFETENRELTGAEKVFLETGMAIDPNAAARMDKMYANGSWRVPTLAEFLDFMVEYVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J960</accession>
    <name>A0AAE0J960_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_432961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3338971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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        <source>
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        </source>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
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        <location>
            <begin position="128"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062822545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAJ2"/>
    <dbReference type="GeneID" id="87859699"/>
    <dbReference type="Proteomes" id="UP001278500">
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    <proteinExistence type="predicted"/>
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            <begin position="26"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3340326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="129" mass="13730" checksum="C536CD0E3D6F4C5C" modified="2024-05-29" version="1">MMGRTGPSCVEILLHLWASRSSCLALHGLQIVLPLKNNGGFGLGSVTGQNLPSPKTCAVRLFKASRCEQEKHPKPTATLRVGSYICLQTVAIDCAISAAQTDIILSSPELQVKTPIIPIGRPEDAPKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAK3340613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679555.1">
        <property type="nucleotide sequence ID" value="XM_062822676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAV9"/>
    <dbReference type="GeneID" id="87859830"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="216" mass="23806" checksum="4144C6946CA04C06" modified="2024-05-29" version="1">MSRICHRSSENICTAQVQMCSEKITLIMCLVRDTPNHHDTPFRLLPKVSPLSIIDISLQSGCAAGRYCPSNAPLTYSQARIGTTYEEGTAVQLTYLQHSTFLDPAIARTSLSLIACAHVFVRSSPDRDPKDTKEDKSRIVIDSPSPAQPSPNRPHDDITARDPSLGSGVGSLWISLVPCARVLTADRKVRGNTFLLRQQRISYTLPRVGDHPKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB43</accession>
    <name>A0AAE0JB43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_473199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679629.1">
        <property type="nucleotide sequence ID" value="XM_062827188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB43"/>
    <dbReference type="GeneID" id="87864342"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042223771" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="148"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="531" mass="58690" checksum="021F8EADF9BA058C" modified="2024-05-29" version="1">MKLSELLLAGAASIVLAHENVYPDVDESHSHAYDHKACGPEGLGDGSLRLSAADIFGTGDTDALTYYVGNNTRSHPREDLTPPSGHNWSHTTSCFNRISSNDAFCVFTDTSYADGHGISFITTAQRAAYLASLPTFTSPSTTTKPNPAKYTISSIPGKGLGLIATTRIPRGSLILSSHPTLMIDYRVFDELLRTDYISLEAAAISSLPQAHRSAFFNLSTQSKNANVTDGLSRIALTDTIITTNAFDIPPPRPSPPPSHPYASPQEPGDPADDLWYTVFASPISRLNHDCRPNADYRFDWNSNKDGPGLVQVITAVRDILPGEEITISYINPLKSRQARQKHLRTVWGFNCSCELCSRSRGMVEESDRRIRLIKELRRLLREEGKDDGSKVGRGEEEEGWMTGSRGQGDRTKMAESLVNLYEMEGLWGMIFEAYAIAAREYSIVGEAWMAMKWAELAVEFGAMVLGEGDEEVREMKELARDPWGHGSWRSRKSGGYGEEDEGEDWIEGDERPECFGVEDGSDGEDEDEEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBJ5</accession>
    <name>A0AAE0JBJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_279169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679964.1">
        <property type="nucleotide sequence ID" value="XM_062822853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBJ5"/>
    <dbReference type="GeneID" id="87860007"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000001">
        <property type="entry name" value="Fungal specific transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3341022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="769" mass="85559" checksum="877272EF3EF9E10D" modified="2024-05-29" version="1">MSMSDSHESPNLEDLTPEEANRIIHSHRKVRYGTACWPCRQRKVKCDNKSPCENCVKREHPQLCSYKPNKSASGKPSSIPPDLSHSKKRPHSPDAQEGRSLSHEARESIRTYAVEITRYVGQNSIPALLREQTATDEPQDVNYIRQDMRSLLGLDNSAPFPLMSSRHLDRLTSDISSELPSDREVMKLFRTYKEIPQPFWGFVIDIDDLESRLMIYLEDRAKNARAATKTTKPVSASWLAILFAVLAVGSQYHETPYHIRTRDAQKYIQISFHFLRLGNFLLRPNLDSIQALLMTSFVLLNDMKAEASWALLGLTCRLAQSLGLHRPQILDGRQSPEIVKKEMSRRKLWWTCLWHDTLTSLSFDRYPMTHIACCPIPLSSTAETDGWSYLEAMYHLCQIISDRLNPDAAATATYTQILTNCADVESIRDKLHPQLRTKDACKSAMDRLQHYAIKLHTSFVVSVCCRPALQRENSQLEKSQKKYLADKCKENLTETVRMFLAMHQLSVIPTRSWAFTYHGLSSAVLLGILGETKADPEVRQLQGDLISALSATAAKEQTSPQPHIPRSDHDIELSGPLSRALTALKNIYDHGSVVGPTGIKREGSISGPASGTRTPLQINQLAGFPNGYPLYGLGQDQQGRGGGAGGMQQQMGATGPLDPHQSAALAMAEMQQQNGGQQIGAGAEYQGGVPFNMPPLQQPGAAGAGPGPGGVMPQDMSQFDPATYMSPMDLYDSIFWESPDPFNTGVDTMNFDFLAHPPPGQPPQQQFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBY0</accession>
    <name>A0AAE0JBY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24, structural domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_273618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679796.1">
        <property type="nucleotide sequence ID" value="XM_062822777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBY0"/>
    <dbReference type="GeneID" id="87859931"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000016">
        <property type="entry name" value="Putative curved dna-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="409" mass="44636" checksum="660DBE4B2F857B28" modified="2024-05-29" version="1">MASETKQEIDYSLNNPDTLTKYKTAAQISEKVLAEVSKLVAAGEKIVDICEKGDKLIEEELAKVYRGKKITKGFSHPTTVSPAGFVTPYTPLTSDEKEAAVEIQAGEPVKIQLGAQIDGFGSIVCDTVIAPAKDQTDDVIEGRNADLILANYYANELLLRLMVPPGLLATGTDEEKAKAASQKPPSQAKITDLLQKVVQAYDCNLVESTTSWLFDRNEIEGKKKIVIAPGDNTKGEGVPEVGEVWGVEMGVSLGSGKVKQYENRTTLHRRTTTTYALKRPSSRKLLSEVQKKFGTFPFSLRQLEDERDAKSGVIECVRGNVFRAYEVVGDKDNSPVARTLTTVAITKNGLTKLGAAPALDLSKFKTDKKIEDEEILAILAQPLSRNTGSKSKNKKKKTAKKEGEKADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCB0</accession>
    <name>A0AAE0JCB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol-4-phosphate 5-kinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_511067</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679991.1">
        <property type="nucleotide sequence ID" value="XM_062828453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCB0"/>
    <dbReference type="GeneID" id="87865607"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052742">
        <property type="term" value="F:phosphatidylinositol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ADF-H" evidence="10">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="10">
        <location>
            <begin position="177"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="11">
        <location>
            <begin position="277"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="553"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3341049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="668" mass="74538" checksum="D79DC91164083E84" modified="2024-05-29" version="1">MQSGISASKELVSQFNDLLGSSSTFGLLVNIANEQLQPIQTLTSSSPGSSFASNVDSLLTPYIKEKEALYIILRRYDSSPALVAVTYVPDTAPVRQKMLFAATRLTLVRELGSEHFRETIFATTAKELTSAGFEKHDAHTALDAPLTEEEKSLGEVKRAEQEAGSGTSKREIHLGSQMAMPMGDDAVMSLKELAMGEGVGVVSLKVNPTTETIDLLPAPSSTPGSLSSLVSSISTTEPRFTFYRYTHTHNGSEQSPVLFFYTNPSSNGGRVAIKQRMLYPLMKRAVLEVASKEGLNPDKKFEVEEPSEITEESVLAELHPKVVESRGFARPKRPGGSLHNILHDLHKHHGTFKNDRALDRAGYYRHHWTCETTIKQQQSPSSNPTFYSTKDQKYLVKSVPRHSEHSFFREDLLTPYVEYMATHPRSLLVRICDFLGASGYSIGRILRLAPSHHIVMENIMYGRSEAKKRGDVDWEDWDLKPTSYFYPERDIADGALTSEATKSQLADEFHDKIRLSREQADEFFASLEEDTQLLADHNAVDYSLFLVRMHTPQAPGQDNNPDPAAASSSEAVSEVVPTEGPSVPPGPPSWRTGIASADGKYIYRASILDFFWAKHKLQPRVMTALINLWNLLISKRGPMSITTTPEEYRQRFLRMCRSYVEVVGDSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCH7</accession>
    <name>A0AAE0JCH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_220402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680273.1">
        <property type="nucleotide sequence ID" value="XM_062822043.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87859197"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3342480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="356" mass="37567" checksum="836452A1F26CE12F" modified="2024-05-29" version="1">MAAQLEAERKEYETQLELVDASLQDDPENEELLALRNELVNCIQLLKDSLAELKGASAAASAAQKQEPLAIGLSSSTSRNASVQDAEEPPKWSRENHPAFKKPSAATPQPEKEEAPAPAPVVNYQVNDTVMARWLSGDKGFYPAKIVSVTGSSTAPIYTVKFKSYDTVETLRAKDIKPMASASSSSTSTSTPGGAAASSSSTGASGAGFKRKADSDMYPIPSSIPASSAAGAAAITRNSDGITLSAGPELYPGALAAAAAAEEAAGKGKMGDSKFDKDGKPKFKKIKANKELEKGKNKWQEFTAKGKFGKGAAKKESMFRTPEGVNGRVGFTGSGQAMRKDPTRSRHIYQPNEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCS9</accession>
    <name>A0AAE0JCS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_226282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680469.1">
        <property type="nucleotide sequence ID" value="XM_062822129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCS9"/>
    <dbReference type="GeneID" id="87859283"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042127907" evidence="3">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="251" mass="24944" checksum="4074090CBBF7FB43" modified="2024-05-29" version="1">MARIHTLTILLLSLLSLVSASAPTFCKCTCFSNSTIIRLGPQPDDPASGAPNNPQQPPPPPPTKPTATASPNNSPRSPNPNHSNPHLFGLSKRAASSSCTQCNRAFCLQYNLPICKDAEEKDVTTTCFQRDSRKDEIIVWGFILGTAGLLGWAGVRRVWEKGQGQVAGIGGGRGGFMGGGMGSGVGGSGRAAGGGGSAGGGGLGLGRMGGGLFRRVFAGGVGSGQGGGRGGGGGGGGAGQGAYSPLGGEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCW2</accession>
    <name>A0AAE0JCW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_231557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680637.1">
        <property type="nucleotide sequence ID" value="XM_062822193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCW2"/>
    <dbReference type="GeneID" id="87859347"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="673" mass="74207" checksum="1B84E24E2D74833D" modified="2024-05-29" version="1">MAETETPALSVESNPNTPKHVKDKKCPWCGQPFTSSSLGRHLDLYVRPNNPKKPDGIHDVMAIRRLRGTITRRRTKGTSRRRDASASAAGSATPGAPSKDGISPAPSDVVQSPAPTPAATQSNRGSVRTPFGRNYPFNTPWEATGVIDLTQRSNGVASHPEERQALPDGPRPLAPVPPPPPPHTSSFVQQPLHHQPDPRQLIQDAQDTARAAELALREIVGSWRAAKLHIDVHSMPFDFDPLTLDFPALVLQCLEPPPTIFSSTFYPTSTSWSIQPPGWDQFKALENHFQEEFKKWRLNCKAATTAFNEDLSYPPPVNFVKVDIKEAIRRSESINKSLEKSVAEHLKKTFGVWEALSQFDREKMWQLELARSVARKQKEINALKEEQHRVRQENNNLKQQIEHLNMLQQPREYKLQTPATFPAEKKLIDYMSELMVVHKVSGVGMEPKGRHHDLNTVCKEAIDRWKKVVQSGRQGPPAPPQGQQQQQQRPQITGPPPTLPPPPPPPPPPPPSVQQNGSMHHQSHHQPQHQPVYQPVSEPQFPQAASVPGGGPPSHNPIQNYYSAVAADYAARNSSSSSNAAPQQSQQQMRDRDEDIEAVSDDEDDGDDGEEGEEGDDGEEDEEEGDDEDAEMAGTEEPQRSHKQPQRQTEGSTGGTGGGGGSGNGAGEPMSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD58</accession>
    <name>A0AAE0JD58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_226429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680473.1">
        <property type="nucleotide sequence ID" value="XM_062822131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD58"/>
    <dbReference type="GeneID" id="87859285"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3342680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="210" mass="23257" checksum="D32E390816993E76" modified="2024-05-29" version="1">MVQKLYVTYNDVHNLCREVAPKILETFNPQLMIAIGGGGYVPARILRSFLKRPGSANIPIQAIGLSLYESLGDNVVEEPGTKVTRTQWLDLTALGSMKNLIGKRILIVDEVDDTRTTLEYAVKELQKDVEAARQALGEGEETQFAIFVLHNKDKPKKGTLPEDIISQGRYFAAVTVGDEWICYPWEAGDIEEHDRNAAEAKAKKAAAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD77</accession>
    <name>A0AAE0JD77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_540038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680122.1">
        <property type="nucleotide sequence ID" value="XM_062829137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD77"/>
    <dbReference type="GeneID" id="87866291"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="303" mass="34352" checksum="215C4438E06B29E0" modified="2024-05-29" version="1">MEVPKTLMTQSPVIPEAATANQARTLNTALVTDQDSNEDSDEDSEQWTLLGNRRKPRREIIQWIQSTLAQKFNLTCKQTFEKTEATTDDVLLILSTLWERAVDIPCDPRHQLAFHTLVLIGGIGFRPGTYENMLYQQVKLLVVRDPDTKQPRLVAEITINQNKLSANKIDKGADVVTFSATMVPCQIVCLVTFVAIQALHDDAFETEFSSFDELLQRPNLEDVDCIELRWKDGMQEKPIFPLKYHKFLELWNRRWLVAGNRNTLRPYALRIGGGNKIDGKNPLPVSLTILLTIFTQGSLTSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD97</accession>
    <name>A0AAE0JD97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_228684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680533.1">
        <property type="nucleotide sequence ID" value="XM_062822150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD97"/>
    <dbReference type="GeneID" id="87859304"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000043">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000294">
        <property type="entry name" value="MFS transporter of unkown specificity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="77"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3342740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="558" mass="60092" checksum="2D1076D924ED543A" modified="2024-05-29" version="1">MSATPRLSPGGHPADLNTEGYREKGVDSSSPSSEGEMEETDLEHAAAQSQRDDLARTQSQAHSFLAPKLSLPHEIAFVGVTCCAQLTTQASMGPSLSIGREIGREFGVMSAADVAWYLAAYALTIGTFILICGRLGDLFGHKRMMVIGYTWYAVWTMICGLSVYSDSGNIMLIVCRAFQGIGPSILLPNGLAILGGSYPDGPRKHMVFALFGAMAPGGATLGCAMAGVFELAWWPWAFWSFAIALLFLAGAAQLIIPDSVDAHTTSSSFVDKLQQLDALGGTVGVAALVLINIAWNQAPIVGWTEPYTYILLIIGILLVPVFFWIELRWSSYPLLPLDALKSGDIAFVLGCLACGWGSFGTWLFYNWQWFLEIRGESGLMATAYFSPVAVSGAMAAVVTGIVLSKIGPAWTVVCAMCAFFTGNMLLATRPLEQNYWIQSFLTVVITPWGMDMIFPASTVILSNAVGRRHQGIAASLINTVVNYSISIGLGFATTAEVYVNKGGTSKEELLKGYKAASWVAVGMTAFGLVLSVVYLAVDIRKKRRVGRAVMSEEEEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDH6</accession>
    <name>A0AAE0JDH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_469359</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680591.1">
        <property type="nucleotide sequence ID" value="XM_062827006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDH6"/>
    <dbReference type="GeneID" id="87864160"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3342798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="289" mass="31977" checksum="A8883B9726B3CAE7" modified="2024-05-29" version="1">MIHDAVLDYYGRRLATCSSDRTIKIFEIEGESQRLIETLKGHDGAVWCVAWAHPKYGNILASAGYDGKVLIWREQAGSWQRIFDFALHKASVNIVSWSPHEAGCLLACASSDGNVSVLEFKDNSWEHNIFHAHGLGVNSVSWAPATTPGSIVSSNPGPGSTGNRRFVTGGSDNLLKIWTFDPATNGYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASQDKTVRIWTSDAANPGEWKCKVLNFDAAVWRVSWSLSGNVLAASSDNNKVTLWKENLKGEWENVKTIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDP5</accession>
    <name>A0AAE0JDP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_469849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680746.1">
        <property type="nucleotide sequence ID" value="XM_062827034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDP5"/>
    <dbReference type="GeneID" id="87864188"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3342953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="242" mass="25879" checksum="503110C25705D9EB" modified="2024-05-29" version="1">MSTSSTTSTAIIGSTGLVGSHILSTFLTSPTTTSQIQTISRRAPPNPTNSSLLSPTVNSDTSTWPTLLSSLVPLPTTVISSLGTTRAAAGGIANQWKIDHDLNVDLAKAAKQAGVKNFVFVSSGGMRGPLSTKFPYAQMKVGVEDTIQSLDFEHGIILRPGLILGEREKAQHAGQGLLYGVVRGLGRWVSLGVQDRFAQEAEVIARAAVKAVRMVEEGKAPGKWWVLEQDDIVKLGRDEWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDY4</accession>
    <name>A0AAE0JDY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_572748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681207.1">
        <property type="nucleotide sequence ID" value="XM_062830518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDY4"/>
    <dbReference type="GeneID" id="87867672"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="295" mass="32375" checksum="AB5D7465B39B293B" modified="2024-05-29" version="1">MLIKESYADVKTSANGKESAMRIFLFHPTIPGYPNARFPGVALFSEIYQVTGPVARFARQIAGQGYIVAAPSSYHDFTGPEPLAYDVPGTDQGNEWKVVKTLDSYDEDSRRTVDYLRYLPTCTGRIGATGMCLGGHLALRAALDPRITAAIPYFGTDIHSRTLGPNDGPNTSPSAPAPRPDPTTASGFVAPHTIDQFDKLKHCEVAMIFGIKDTHVPDAGRDLIRAKLREAGVTFSFYEFAWAQHAFIRDELSKGRYDPAITKVCFEVLLETFGRVLKTDLGQGTGEKEEVEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JET6</accession>
    <name>A0AAE0JET6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="10" type="ORF">B0H65DRAFT_465346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JET6"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="TgpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Protein-glutamine gamma-glutamyltransferase-like C-terminal" evidence="9">
        <location>
            <begin position="299"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3345047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="660" mass="72544" checksum="5933FA5DCD9C4EF7" modified="2024-05-29" version="1">MKSAVSIIAHFLYKLVYYFIYLVLLAFLIVSPIDLIRQAIITKQNYSILIVALCYLVTILIIVFIYATRLYYNKAVLDSIPKSWVPIEKGDVLRDVRQLIVAGLSRSAAIAYEARPRLPLPSPLAAPGAPHPTSQRQEMERNDNEGQDGEPQQEHSGWIATAAKEASKEAADRFTGKRSRWKPKVRRGISADTIEGRESEHNSTTTRPSGHDEPVSINIVAPRGGPHIWGEIEHPGWASPTSPDLANVQYDAVISELPNLIEAKAITLAPPDRTSEGGGGEGEAGRMDPPLLDPDAVALLQRHESMGLREYLTSLTELGVVAPSEALSEFIKLYERARYSTRPVSIDEFRRLMHVFAEVLRGMRPLDPVVLDEIVGEYEDDGAEDNDSENARDKGTEGDGSNDRRFLSPYSQKQQQPSPRSFYESDIDNDAPRRSYSSGDLRRDSDGSSMYHGQRAHQQQQPPRTPTPKTPKRRKRKAKYTTAANPSDPGPSDANPLRGLNHLTRQQTNSSYFSSSSSLRSTHTHNHLRPETAKTAKTHFSSRSHPHHHQRSANRNSSGTYSTTYSWQQQQRQFRTAPTTPRSVAMTAGTTGLYRAGTNGTGISNGGVSQLSLASSSGSGRSARSARSGGTSGSSGSVIRLAGRGDQTDLPYVLMPAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFA5</accession>
    <name>A0AAE0JFA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_548980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681865.1">
        <property type="nucleotide sequence ID" value="XM_062829620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFA5"/>
    <dbReference type="GeneID" id="87866774"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3345252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="152" mass="16367" checksum="2AD0B4A346047400" modified="2024-05-29" version="1">MASHDEIWDDSALVNSWNEALAEYKKYHSIHAEGAALPEGVAGDFKDQNAKPSAATDVHQQEGEEVEEGEEMEEDGAAPAVEVKIVESQQPAAAAGPTAATATSLPGPGPQLMLGSVQDEELKKLLMSWYYAGYYTGLYEGKQKALQEQAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFM9</accession>
    <name>A0AAE0JFM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_466783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682094.1">
        <property type="nucleotide sequence ID" value="XM_062826878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFM9"/>
    <dbReference type="GeneID" id="87864032"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="379" mass="42208" checksum="BC8C12BB875C05D1" modified="2024-05-29" version="1">MSSPAKKAQSPAPQSPTPGPASQSPAAAREPTPGPAPPAVETTGPLPGSHWAEQGLPEEEENDGDSTIGSDIESSTASISSSILKYRTMNGRTYHSDSVTDGEYWGPNDAKQNEMLDIFHHVMTICLDGRLYDAPLPKNPENAIDLGTGTGLWAIDFADKFPKCNVIGTDISPIQPGWVPSNVRFEIDDYNKEWTYNSNFFDFIHLRWLSGTVKDWPALYKKAYQCCKPGGYIEHMDASGTVLSDDGSVDNKIHAVAQWGPMWQEGGRRIGYEVDLHSTNLMENAMKEAGFVNIVTKDYKVPLSPWSKDKKMNELGLYLYVAMGQDLDGILQFMFGKVMGWTTEEINIYIKHLQKELKDTTLHPYFIYRMVYAQKPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFW8</accession>
    <name>A0AAE0JFW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_210328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682229.1">
        <property type="nucleotide sequence ID" value="XM_062821925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFW8"/>
    <dbReference type="GeneID" id="87859079"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="249" mass="27841" checksum="EE24C32A7968EFDE" modified="2024-05-29" version="1">MIPVWSNQTSGQDPGWLHALSQAIMNLDGRLPRRCTRSRARHQRDGSQHHASEAVRHVFPRLDILVMTRSLFSPMPRTSTNHPKIWQRHVSVQHWKTSMWFLSLAKAAPERMNSQKLVPGMASPRFVPDSRSSGRPVGCRLLTSTARDQILNKVMIDNSDRLIALLKKELDRQNGVAEEACELQHTRPTGIKPKDTESQATETSETRRGDDLQNLGATGNGAQAGDDLEGLDHGSGSTKSEKRNTECRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFZ6</accession>
    <name>A0AAE0JFZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_466164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681901.1">
        <property type="nucleotide sequence ID" value="XM_062826839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFZ6"/>
    <dbReference type="GeneID" id="87863993"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="88211" checksum="E8C98ED37F0E1098" modified="2024-05-29" version="1">MPLQPGRTLSSRWLSRAFCLDRCTTTSNSAAKLPLYLCPAFRSAANLSQSPRRHNHTIPSVQCRRLHTEATHEAHTPTEPLHAEKEPTRTLPIQCTGCGALSQTTIPEQAGYFDLSRKAVKEYVGLIEPEKRKVIRSSDRVIEDVLKNVDMEELERMGVDLKSLLPKDYQANKKSPEPEGPPHPPLCDRCHELVHHRKGNSIFHPGIDSLRETIEESPYKYNHVYHVVDAADFPMSLIPKLERLVGALPMRSKNRRAKSETWHAGRQINLSFIITRSDLLAPKKEQVDRLKPYLVETLRQALGRIGNRVRLGNVMCVSARRNWWTKELKEEIFEHGGANWMVGRVNVGKSRLFHDIFPQGRMNWQESQKLPVLPAFRNDNITYGKLDEGDDALLPPAQPETNYPAMPIVSDLPGTTASPVRVPFGNRKGELIDLPGLSRGDLELHIKPEKRADLVMKMRVVPEQAVLKPGQSLLVGGFVRITPKTPGVTFLAYSFTPIEAHVSGTEKAIAVQEMREDAPNVENIALPETAEKIKHAGSFALKYDVTKQRSGPLTRKNACGFKVDTLPFRVLSIDILIEGVGWVEVVAQVRAKSLQYNPYRDEQAEKEKEEEEEETPETAVEGQNEEKKEEYWTDPLPSPSKSKKSSSTFQDPFRLDHLDLSDPNDEPQPKPKPVPKPEEEEDPLAPPRLKDAEVVEETEEESNQRKKKGEEEEEEEEIKLNWPIIDVYSPEGKFIGSRPPMGAWLLNEPKSDGKKRPRKAMKGVKKEKKRMAREKAAAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682285.1">
        <property type="nucleotide sequence ID" value="XM_062825607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG37"/>
    <dbReference type="GeneID" id="87862761"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="273" mass="30121" checksum="61973E44A2A1CAE0" modified="2024-05-29" version="1">MPSITTLLAYCALCVRYASKPLRTLHGKAGFPILHYRGSELDLGECRLLPSALNALFSLLVILGKYVEAAAVPQEPRCNRCYEHSSRHRERTIEPSSKTATPERTQPEVGNMKWKEPHYRNFCPARRLKRDSSIANFPSYYGSLCPGAHLPTLLPKPLGFHASVSIFLQHQPPTLSDTSFPPYPGQPFFGQIVMSLPPANCPFLDSRSNCEQQCPIVPTPSARPVTTPSQFAPSRPVYLRQSPMTEVGGAVQVFPASSAAFPNASRRNGPTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG46</accession>
    <name>A0AAE0JG46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_549350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682284.1">
        <property type="nucleotide sequence ID" value="XM_062829655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG46"/>
    <dbReference type="GeneID" id="87866809"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576:SF2">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="125" mass="14114" checksum="08157AC1E4523144" modified="2024-05-29" version="1">MDDILWMYRQLALRVSVIAAIHTNETKCVPYFSERIEGQWLGDNERAQLCYTMALVTGIAGIVAVIVLHWGCWKLDRVYSMSPLELLNALAHRAQSPQSPFHVLAKAEDNVSAFTVEEVRGRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGC6</accession>
    <name>A0AAE0JGC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_570027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682434.1">
        <property type="nucleotide sequence ID" value="XM_062830434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGC6"/>
    <dbReference type="GeneID" id="87867588"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="235"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3347352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="555" mass="61615" checksum="E2308F49C4E8133C" modified="2024-05-29" version="1">MSTFIFSANVVALIQVKISGAQYRIEFTKPPKNGQCWIIGSAPTADVSIGHQTQGISDKHLGLDFGQDGMVIIKIFSSHGTSLAYHSVSDDEKVDSMVHECMGEDSPRAPAWAVPVGQRIHIFLGDPRNPLELTIQAFDHNQHLSDYMEAIKHLKASAPEAAEPTQPQPSKELSPCPSPPPPTPASGVATFMSRALGGMEIATPAMPGGTEMPSLTRFAYDIGKYTYSFLEVTPRSNQMRPGSGRVVKVLSTKTWNVYAAKYFNKRKIHLLYKEFEVFTGAKLRKAPHTIAYFERFLVPRGINKQHMLVMEWCDLGSMVEEGERKSFTYHESCMIVDQVAKALMYLHGQRFVHRDVRPQHILVRSRTTSRLEVCLTDFSSSTKIPIVTDGTNGSRWAEDEAYIAPDAFASSDQLREEHVKNLAAVDIWSLGVIALELLTGSLPTIVYETPQDMQHPILVSGQQFTKALINHRDEMAKTPAAAANGGLVPLIMEMLCPSPYYRMTAQEVAGGTIILVTLMKDDSRMEYYRKKYPGGQFPAVAAPRVHAYNLWRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH93</accession>
    <name>A0AAE0JH93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_570678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682723.1">
        <property type="nucleotide sequence ID" value="XM_062830457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH93"/>
    <dbReference type="GeneID" id="87867611"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="164" mass="18284" checksum="5BDACEC324DA6C79" modified="2024-05-29" version="1">MSTNMYTEGIISMIKRSEDKYPHDYPTATRMGYAAGLVGLVALTVSDDYMAEEFYDTIRGYAATLRQERALAETDESTAKLLSREFICYDILDLVSDLEHNHNATKANRDVVSNNAVTVNEGIESVINMNAVVQAEEDTEFVLINEVESDASHSEADSSEWELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHA5</accession>
    <name>A0AAE0JHA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SprT-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_521540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682561.1">
        <property type="nucleotide sequence ID" value="XM_062828754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHA5"/>
    <dbReference type="GeneID" id="87865908"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="837"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="837"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="938" mass="102334" checksum="7A3B3F875C3427CF" modified="2024-05-29" version="1">MARLSRPPPSSRSRKTIFSSSSESESDSNNDSNSDSDFPDLAALPPSPKKKRKVSPPLPATKKRPTPPTDTASISGNQTVVESATSPNAASSSVAGIKRRKLLLGAVSDNVLFRKWTPAQEEDAVPTRKKRRDLTAGTGFGLRLGMMRDEDEDEDGDSEAENPVVLNRKKVKEVKRVGESTVTAKTVVRRTTKSLFSSQTTLSKKHREGEDMVGTKNEEKKPSASLFRPPKQVAGKSKDMMEIDQEQDMDVFEDLEDFAEESFHTAQSKESSESDEVGSETTVGKGRDTNTASNSKDDDSDEDLDAFFSKLSNKPKTPAVRESHLSPTKPRSTKNSRGKRMDTSWESQSRTLFDEEESDGRRERIGKRAASSEEDSCGEEDVTQDFSCLQLESSSSSSDSSSETETERRSRPPAAAAAGTRKRTQTPSPPPPKIPRLKPKTSATLPPSPKKLPRIPTTPHRPSSDLFWSREFVDDWNDEHSPKKELFPSSTKPPSSEEATNSPDKKKKPARRAQPSPQKAAALLARESRLARQAFDAHKHSLATHFLALLDARLTSSRLSALTASTGGIKLVWSKTLNTTAGRANWKKESITTRPSSEQDANKEVKHHASIELATKVLSTPERLFNTLAHEFCHLAVFMIDGVTTRPHGAEFKAWARKVNDSEFGRRHRGGPKPFGKMNIIREGEGEGEGGGDSSGKVEVEWEGGYAVEVTTRHGYEIEFRYVWVCDGVVNPPGSGSATAAGQGGEEGKGEGKGEEGKDKKGGCGTEYKRHSKSVDPKRHRCGVCKGVLRQVKPAPRGQGQQGGGGKTSSSSSSAGGGFDGDGSQGGMGTNKIKVEKAKTSSEYQVFVKEQMKVVKAQKPGLAFGEVMKEVAERWKVEKARREKKNKKEITPPAETTGKLSTVLEEVVADEEDGDGEDSPDMFEDEPMMDVVDLTADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHD3</accession>
    <name>A0AAE0JHD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_153396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682778.1">
        <property type="nucleotide sequence ID" value="XM_062821111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHD3"/>
    <dbReference type="SMR" id="A0AAE0JHD3"/>
    <dbReference type="GeneID" id="87858265"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="143" mass="16861" checksum="59ECFCE59E78B6BA" modified="2024-05-29" version="1">MGSIVLPHLETGWHVDQAILSEDERVVVIRFGRDHSPDCMRQDEVLYRIADKVKNFAVIYLCDIDKVPDFNQMYELYDECTLMFFFRNKHMMIDLGTGDNNKIKWVLEDKQELIDIIETVYRGAKKGRGLVVSPKDYSTRHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHE9</accession>
    <name>A0AAE0JHE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_423112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683040.1">
        <property type="nucleotide sequence ID" value="XM_062824436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHE9"/>
    <dbReference type="SMR" id="A0AAE0JHE9"/>
    <dbReference type="GeneID" id="87861590"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="90" mass="9893" checksum="E4750BE4131854BC" modified="2024-05-29" version="1">MPNKPIRLPPLKQLRVRQANKAEENPCIAVMSSVLACWASAGYNSAGCATVENALRACMDAPKPAPKPNNTINYHLSRFQERLTQGKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHI7</accession>
    <name>A0AAE0JHI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_155321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682853.1">
        <property type="nucleotide sequence ID" value="XM_062821146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHI7"/>
    <dbReference type="GeneID" id="87858300"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850:SF2">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31889" checksum="8F56F42638BBC1CA" modified="2024-05-29" version="1">MTTESHSFAMCTTRLVTHSNLWISRLSSLALLVLYCATATHAATTTVWATPHDSYSSSIGVLGCKVDTDRIAYWPSSVDCNNLCVSLSYGDRKVKLLRIDQSQGAHDISYDAWNYLTTGHGANDRPAVGGPIEMQTEELDASECKDLIHTEGHKLPLSAANSMNFLASCLDHKNGSWVGENYILYNILDSICTWGYDEPCELNWPSANQAQCKHALGTPNTLKDDPVYDIKYPSGNKVIAGSGEVVKTGGTPWGDVGGTGQENAATRGLVAGSSATFLFVWIMTMMSYGALCWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHL7</accession>
    <name>A0AAE0JHL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_424055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683109.1">
        <property type="nucleotide sequence ID" value="XM_062824492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHL7"/>
    <dbReference type="GeneID" id="87861646"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="66" mass="7554" checksum="FB14BAEEFF8EBEDB" modified="2024-05-29" version="1">MRRSTTPAGSIYPIVSTLSGKSFKIADPPVYYVNKTKDTVAFEVWYRFVVNKLKVNNDYFADDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI02</accession>
    <name>A0AAE0JI02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_423119</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683320.1">
        <property type="nucleotide sequence ID" value="XM_062824437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI02"/>
    <dbReference type="GeneID" id="87861591"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="263"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3348238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="380" mass="41456" checksum="495EA1D65107877D" modified="2024-05-29" version="1">MSTETSDGAKPGAAPAAASIDADNNKNDEIASVPPASTATESEPDAAKSTVPAATTDETTKLQPVAAQVTDYPADIEGDARSVSPPAPAHDYPADIKRSVSTTATQLSPLAQLWKAAEGHPHFEIWGVPLSDPERHIPTQIIFQKFLNANDGQVEKAKDQLLKTLDWRQKTQPQQLVRKMFSKAKFDGLGYVTTYTAGDEPAVDEPEQKEVFTWNLYGSVKSLDETFGNLQEFVEWRVALMELGLVEVNIGGAIKPITADYDPYKMTQVHDYKGISFLRQTDVAKAASKETITVLGDNYPELLKEKFFVNIPAIMGFFYGVMKMFVSKKTLKKFHPLSSGTNLAKEFVNTKVDGLGDKLPAEYGGKGADLKTLGKTPIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIB2</accession>
    <name>A0AAE0JIB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_165068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683156.1">
        <property type="nucleotide sequence ID" value="XM_062821283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIB2"/>
    <dbReference type="GeneID" id="87858437"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="159" mass="17068" checksum="64DB2CD0D802E794" modified="2024-05-29" version="1">MTLSVACIGIACNTVESIGSIVKLRRSGTRQGCSRQGEQIRAGPATMSITYLHTAGPAYGGRTGSASRGGTPKSRCKSGCPGQWTGTELYRLPTGNRPPVGCRRRHGSQRQPSPDTVHKRAGLQVRCRRNMEELPNGGDPCARPPPEPPNRQALWPLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK14</accession>
    <name>A0AAE0JK14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_107096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684344.1">
        <property type="nucleotide sequence ID" value="XM_062820504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK14"/>
    <dbReference type="GeneID" id="87857658"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="90" mass="9870" checksum="CC3331BEBAD7DE55" modified="2024-05-29" version="1">MILYPLAWQSRTAPLYRRRRGLTLPSKKADAQPKICPEARPVIGDQVEGAQATNRNTVTEGGETAENRWLSVGPAVWSPVHGPVDFVECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK74</accession>
    <name>A0AAE0JK74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_109559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684475.1">
        <property type="nucleotide sequence ID" value="XM_062820554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK74"/>
    <dbReference type="GeneID" id="87857708"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF14">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="346" mass="39437" checksum="C9A669182C9DE71B" modified="2024-05-29" version="1">MTFLPSNGGLHGFQFTFETYLDSSSQKIEADSDHSSPSRDIYDSVSLSESISKYEEEFGRTYHSYRAGSYHYPNDPTETERLDDQYEIAKELMEGRNYFAPFSRKNPPRKVLDIGTGTGTWAIDMGDEFPEAEIIGTDLSPVQPDLVPPNVRFFVEDSSDEWIYPTNYFDYIHTRYTLGCWSDMKSQIIQRAFDHLKPGGWLECQELNVLPVCDDGSMTDDYKLLQWARDMDAASRAADRQLVIGDDIKQWLGDVGFVDVQQMVLKLPVGGWAREPRLKHLGMLWQRNLSGGLGGLSVGLLHRFGGKTIEQVEVDLVGVRNSMFDRNVHAYMKIYIVWGRKPDVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKH2</accession>
    <name>A0AAE0JKH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_114000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684610.1">
        <property type="nucleotide sequence ID" value="XM_062820626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKH2"/>
    <dbReference type="GeneID" id="87857780"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="428" mass="46208" checksum="ABD84B6E68FDB4D1" modified="2024-05-29" version="1">MTPSSPQTPRHSPYPSMENLRSAASYSPQEGRALSHKSSFNDPQEGPALSHKSSFNDPLTPSRNSFNSSVGPAMDIGMFGNGGMDNGGGLGNLADELADAFSDGEDDYFEGQEGEEAPNMDFKGEEEDLLPTPMPKDGGGIRDSGVDVASPRSRQRASLKSQLSPNGRGHHHHHRRKVSEYDGSEYGSESDLELSGLSPRLVEKMAEVESLARRGTENNGSAADGAFQRVTEGLRDLGSQAGVEGGATRLITAHSALTTHLTHQTRQLHSLSFPLLSPLSPAPDAEAIDELLPMLVSLSTCMPRPSTAAFAQLASLHTITTDLVQTLNYLSDTLHMSRQTTTTATRRLKSARELVAELKREEELREQGERWLSRGNWSERLRNRECAHVCGEVVGGFEEVCNNWRKRLLAQAEGGGGDGTGTMGSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKI8</accession>
    <name>A0AAE0JKI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_115160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684642.1">
        <property type="nucleotide sequence ID" value="XM_062820642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKI8"/>
    <dbReference type="GeneID" id="87857796"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="533" mass="58932" checksum="4A459AFBA16E8CCF" modified="2024-05-29" version="1">MSAKSSPSPFQAPANNQVDETTMPKGHCRYILCVPEIKGHRCACVGFSHNKGIPGATCECGHLACYHQKEPDSASGDQIELLRRRIQLLEEQLAGGIGSRLSDVEHDLEKTRGIVSRLTDVEETLEKSREEFSEQIKGAYRNMSISWRSIEQIERKTQHQDEQLRQVCERLGAHDAQLDRLHAGQLELRDADISLEERIENIAETMEELEDAQDAQDDHLARLNGRHPRRRSTSDTSRPNFPSGPLGPLGGGANPFDSHGHSHVAQPPVQRGHGEGSGLDGTLISHPTKTPPLSARSTGAWTVHISLLPHARVPMPFERNTNAYQRCLSRGLHQMVAVHGRDAASFIKAVEKAFGMFLKGRPWMPLQAKLCDAEPLQGLPMLRQLEASLVDSSYDHDFLRQNCAVCDSSGMMDSLYIAMRHDTISWHTLRHAPVFMEDLEAAWAYDPMLDTDPFDGDMAVDDRERPAAGEITTVLPSLAPSSSLKRSRAEMSRSNSFGAAAPPVDGEATRAKRTCPAPPSSSILELRRHVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKM9</accession>
    <name>A0AAE0JKM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_458085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684795.1">
        <property type="nucleotide sequence ID" value="XM_062826381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKM9"/>
    <dbReference type="GeneID" id="87863535"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="75" mass="8368" checksum="2F834C29982BB1AE" modified="2024-05-29" version="1">MESLVFLTCTPSVALSTSHWDSLCDLRRLSRNTALRQQPKRQDAVTDDSALMFTYVLGVALEVPTLEDLRVAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKP8</accession>
    <name>A0AAE0JKP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_568515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684689.1">
        <property type="nucleotide sequence ID" value="XM_062830395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKP8"/>
    <dbReference type="GeneID" id="87867549"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3351394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="525" mass="60455" checksum="7BBB18D9C6CA68A8" modified="2024-05-29" version="1">MTLLADFLPSVTWWHVAVAVTVYYRLTLHPLAKFPGPKLAAITRLYEGYYDVIQEGQYTFKIGELHKQYGPIIRISPYELHINDPSYFEKLYRQDGRWDKYDWAYIAHGRGLDTAISAPDHYLHKTVRQPLSPFFSKANVGRKLGIVRKHLDKLEGIISRKAASKEVFDLGAAISAWARDVSNEFILGKSYDNLDKDDFDKDFTTMVTDEGRQWRWNKHLPILRVAFILPWDFMIMVGDKGMKNVFVTSRYIIDAHLSNTSSSEEKPTHTHTIINDILDSPSLPSHIKSTSRIHQDLFVITAAGFETTASTLRLILYHLFSPPHTILSRLRSELSQFNINLSDLDPTSYSHRYRELEQLPYLTAILMEGLRLSPALASRMQRVAPDRELVYPCPQHEPNDGKNRKEWVIPRGTPVGMTQILMHWDESVYGEDAREFKPERWMDEEFRRRVAGGERMWAPFSRGARNCLGMHLAWAELYLCIATLAQHFDLEFPGHSAEDFEAAIDSFVILTKSRGELRTVAKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL45</accession>
    <name>A0AAE0JL45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_115736</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684653.1">
        <property type="nucleotide sequence ID" value="XM_062820646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL45"/>
    <dbReference type="GeneID" id="87857800"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000062">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="15">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3351358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="602" mass="67890" checksum="72FECED574913C53" modified="2024-05-29" version="1">MTLEFPVIFLLPTNLGVDELHELEEQIPTLTYDINEAEVVLGKVHRRERALFELRKHKLVTEEISPAEEDEPTSPSPKRRRFQTPGSVITEDSDTASDGEFHPLLTQPTQSTLKASPTTVKVVKLAWFTECLKAGTVLPIDDYTLYRGRKQLGKPTKPKEVSPAKAADVIKRALADPKPSFHGSRPGSSHSTASHGRRDHFITKAPALLHMTTSEHEVELPPIPAYLHTTYACQRPALMHPPNEPFIKELMKIRIARTLLGDKIGVRAYSSAIAALTSYPYPLRSAFEVARLPGCGLKIAQLYQEYREHGELQEAKEDQSDPRLAVLKLFYEIWGVAETTAREFYNKGWRDLDDIVEYGWDTLTRVQQIGVKYYDEFQQKIPRAEVESISDIILEHANKIHPGFQMVIVGGYRRGKLASGDVDVVLSHPDEAATRGFVEQIVVALEQSNYITHTLILSTANTERGQVPVAWKGNEKRAGTGFDTLDKALVVWQDLHWTTGEKKNPNPHRRVDIIISPWKTAGCAVLGWTSGTTFQRDLRRYCKKERSLKFDSSGIRNRADGTWVDYESGPNGEPAPDMLTAERRVFEGLELEWRPPEERCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL92</accession>
    <name>A0AAE0JL92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_457877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062826373.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1280"/>
        </location>
    </feature>
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        <location>
            <begin position="1304"/>
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        </location>
    </feature>
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        <location>
            <begin position="108"/>
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        </location>
    </feature>
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            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="1312"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3351433.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1326" mass="139573" checksum="1ACD70B31D5EF59B" modified="2024-05-29" version="1">MAAAAGGPLPFGALISIVLLGTFTVSATLAFLGIWLSRRRRLAVAAAGQGQGQTNKERSGCHVHDLTGETAIASTALTVHVGNGHNDVLDGEDFSPTKRSPRKLQKLPSASWTTASASRFNSTTSLLPKVKEKGKGKGSREDGLRENGGGDGEGEDVFSVSMLPGMSWTGMGGAQGQGQGQGQWSLLPFSRLRKTSSGSLLRLHKTKLLGVGRKKSSASERRMANSAWIDEEALHGPEVSGLSNITDESGNGNDNENNGHRKSLLFGWRKGKGRDWIRESWPLKTRTPTVPRLDDYQELAGSQIQSQNQVQASDRRAEQLETETMTGRLGIPSTDSGRRAVRSAYGAMEGGGGGGVLPVSLLLPEPPQPAIVRGQAGTGGGFVVQHRHTKSEPQRILRVTNPSPTTSSARPTPIPRTQSTSTKNRQVSTESTLSDILRSTERRLQEGGTSGVSRRNRATIAAVSGPHRGLSLHVAKRLEESRDPGLRRSESLKETRRTRTEHELPVISPSSSGLVAPLTLVPKSSGQRQRPDSRESSSSEPDSLLAEPAYSEMPSGLTSPSRVSSIAGASSVAETEIEMLLMTVDVPSNRNSMTSAASLSTIHSEDESSEGGARVSAGTKMPSPDRAAMVAGTGRPAVTLQTSKVNNERFTLPAPLSAVNASAPSLPSGSSTRPFTSYGCPVPRPLSTRSQGEAESNRRSFVRKSIIAQEPIGPMPSMPTRLLPCPGVPSGKNCVIAQTSCGKWHTAMADPFQIPVSPTSLQASTDSASPTSSSGSMISRETPRGLRSPPNKSTTYNNTLLNSIVLPPPTQHRYVDAKTVVGESKPPARPGVTQTPERERRWPFIAARTGAEDGNNYQPPSPTPRSGSRLSRQLSLQQQQRKASESSSVYSQDIAANEAFSPASVPAFTIPIPSSPTRTSLPPSPTSVGLAAAQALNAANFQRNSILFAGAQQQTPSRRTSRTTNANRVSGLSVRDVEEVGEDDNKENTAATPKASPIAATIAQLRRMNSVLSTASSASSVSSINTDMADGGGNGNLSRRNSRVGLSASPTQSALRGGGFNPNPRRDSHHSYGHRRSGSRNYLFALSGGVGGAGAVPSTTPSTPKVLKRAGGSGSGSGSGVLRPISSGQVNGHHSRTGSGSGSGIGRVVSISRSGSPQRITLTPSQGHHRSLGGYGGNSVLGSPSPINVNILKNRFQFDDDDDNDNNNEGGRAGNVNGITTQTQGGSGFLAGRKKDEGEEEESKKKLPVRFALPNSSPASIGLTVNSPPSSPSPRSKQVQTGMVYVTPKGGRWRQSNESLGLYDRDGFLINSPSRPSGASPSSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JM08_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">AN1-type domain-containing protein</fullName>
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        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAUEPP010000002">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AN1-like Zinc finger"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3351492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="73" mass="8318" checksum="772B9F1147812521" modified="2024-05-29" version="1">MPAPRRLKCSLTECRLPAAPITGDCTFCDGHYCSKHRLLESHKCKNLEDCKKEAFEANALQLEKERTRVIRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMJ8</accession>
    <name>A0AAE0JMJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_143933</name>
    </gene>
    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685373.1">
        <property type="nucleotide sequence ID" value="XM_062820978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMJ8"/>
    <dbReference type="GeneID" id="87858132"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="350" mass="38851" checksum="3FE70E7139F45091" modified="2024-05-29" version="1">MPLIAQSPKPRVILGLMTFGTDTETGARVTTVPEFGKVLDLFQSRGYNEVDTARMYIGGKQEAFTREAGWKDRGLTLATKVIYPTNGGDNTREKVLESADISLKELGTECVDILYLHAADRKTPFAETLSAIDALHKAGKFVRFGISNFTSFEVAEIVMTCKYNNWVLPTIYQGMYNAITRSLETELVLACRRYGLDIVVYNPLAGGLFSGKIKSHDIVPESGRFSDVNKMGVLYRGRYFKESTFRALQVVEQAVEKAGLTMIETALRWVVHHSALKITDGNDGVIIGVSSIDQLDSNLADLEKGPLPEEVVQALDEAWRITKVDTVNYWHGTVEYGYDVREALFGKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNR8</accession>
    <name>A0AAE0JNR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_484269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686334.1">
        <property type="nucleotide sequence ID" value="XM_062827670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNR8"/>
    <dbReference type="GeneID" id="87864824"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000074">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="154"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3354956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="431" mass="47383" checksum="3B5DA86ABF02D179" modified="2024-05-29" version="1">MARHSGLGLNNRHRSSQPTSLPRRLLSALLLTTTTTLLTTTPAGVHAYTPLSTCSLQHLPSGPPSDFDIHPGSGSDSLLAPILIPRVPGTEGSRLVQQHFVDFFSSQLPDWTLEWQNSTSTTPATGSQLIPFSNLILRRDPPWAKAGTKKEGNVKRLTLAAHYDSLYRPEGFIGAVDSAAPCAILMQVARAVDGALGRRWEGVMARKQKEEEGGGLGLGLEDEEFGEEEEKGVQIVLFDGEEAWVRWTNTDSTYGSRALAEAWESSPYEASSTHSNRLESISLLVLLDLLGAENPRIPSYFWDTHGAYGDLAKIEARLRELGVLETAPASPFLPDSGKPYNRFTRGYIQDDHVPFMERGVKVLHIIPTPFPPVWHTMDDDGEHLDLPTVRDWAKIMTAFVAEWMDLDGVLSEEGCVVGEEKGSGSMEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNZ7</accession>
    <name>A0AAE0JNZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_21234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686071.1">
        <property type="nucleotide sequence ID" value="XM_062821951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNZ7"/>
    <dbReference type="GeneID" id="87859105"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="946" mass="101437" checksum="5B59CFF8C8C51B08" modified="2024-05-29" version="1">MSSPILGIPTWSPEFLARKQKIPHRILRVHRDQQELLDREDAWNPDGFANVPAELLQEVKAQYIRSIAPPTPPPRKTLSPAPLSAESVREPSTPKPTGTGSEEGTPIPWSPSPEHHIRPATPVNDVETKDRTPGLEPSPENNSSPKPAITPDLPSRALPERLSSQKRPEHRPSSPLVFKVKARVPFLPEFPPSSSVASEGGLEFEVPKAVTDVLPPVNKGALPVLPVHPEQTPPSAQIIPASYLARTTPSRPPPEKRRRLMKSATTIYSDYRSTAEPERSSAAFPRAETEDPSTTRLSEHIADSQQPPEEQSADTSSHSLKTAEQATQHLASSDEKIPPNGPPSQVPYTAYKVAYPDYKGTLNDFVRAVLCVHDLRKRSAIMEFLYDDFVRYYCDDYLQYIREQVDGNVPVRTAIELYNDQVSRPHYQKGVLTKENINDVLDKYPEMVRSVNETIGSTAPVIEENGDSTRPKVPIPSPSTTNHLPKPRLVSKSITKALVGTPETELASDPIHPPSSIPKKRIRPVIQTIDRSVPRRLSNRPLELEPPIEEEPIPGSDGAPIEIGSASSSPSPSPSPPPVLPQAPSRSQGGPTSSATKVTGPQKQTGVSSPPREASAAFKRPRLETSPPPPPSSSAKITTQLASISPPPPRRASKVDVSSPGHPITHQPPHQGEDMHPDSQIVPGTPAPIRAPAPPLPPTTAPSPSRPGPLITQIPANTTNLPLLSQLSNADSIPDPSAPSAPSVPSSTTRSKLLSSTATTHNKKLPPPSHPALNLNPLSTQISNADSIPEPSLPPRLQRQQRKSSSSALLTSSNLSRLAHITSSSKRFLQQKKQAAGAGGAPSSSASKGSGSVVVSSSAATGVVGSGGIIKVKGHDKGKGKGKGKATAKDTGRDLRSEYFVNFVREKKMREMREATEKAEEAEKAAAATSSSHPIPGSSSNAQQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP66</accession>
    <name>A0AAE0JP66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_36881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686500.1">
        <property type="nucleotide sequence ID" value="XM_062823686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP66"/>
    <dbReference type="GeneID" id="87860840"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="268"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="752" mass="86685" checksum="B12686F7078A997A" modified="2024-05-29" version="1">MSVGVNKLPCEGSSEEAVVEFTHQSEKLSYQPPGSPDNKGVAVEAIFVAPQDPVIVTSDGNRLPAVPATEAYKLNVLRHEAERHDGVRVHVREASRPRDTVKETEDSEGDRVLSFPREKDEKKRSDSTDGNLKRSMPPSSTHPLFPPLPLYGPSSRWRDIHCLLFRFTSFFLSLAFLGVIVLGSLFTSIPPAFQYIWKRLNSKDPDADRPFYKEEIRRKQLREQQVRRWRRRRSASHLDHEDSEDNDEGDSDVKAVGPDPIVCDIGFYARRVGLDVETHLVETEDGFIIELWHVYDPEEYTPLPEEERRHKGPDLFTGKARREPGQTKNDKKPKFPVLLMHGLLQSSGAYCVNDEDSLAFFLCKSGYDVWLGNNRCGFKPRHVLLEYSDPRMWCWNIRQMGVFDLPALTSRVLYETGFKKIGLIAHSQGTTQTFVALAKEQRPDLGEKLTVFCALAPAAYAGPLIGKMYFKFMRVITPAMFRMLFGIHAFIPFMMTMHSLLHPHVYGWLGYKVFSFLFNWTDRRWDRDLKNRMFQFAPVYVSAESMRWWLGRECFAKHKCILATKEEWRAEEKEDRELDKLDKEERSRNEKKADKILKAAERDMEGNKESEKSKQAARRMRPKGSRAWYNHQAPPFALWVCGNDALVDGTKLLRRFDRGREPHVKVVHKKVIEEYEHLDVIWAMDAVDQVFKEIREVLWKTCNARDLCRVPEGCEDVPAWDPAGNEDTKKEDDDDGMESDSNSSSGDEDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPU0</accession>
    <name>A0AAE0JPU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptide peptidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_451406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686648.1">
        <property type="nucleotide sequence ID" value="XM_062826050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPU0"/>
    <dbReference type="GeneID" id="87863204"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="562" mass="62058" checksum="D2E57C8CC6E39F63" modified="2024-05-29" version="1">MASPEAPAVNATGATSTPVPDATPYAFHWEMLLRPEVLLFDAQIIFGALTVIWLGAHGSLRRPPSAAPAESEDKDKKKKSKEDEQFTEGLTASDAIMFPILAGAVLIGLYYLLEWLKDPNLLNKILRGYMSVAGIAGLGKLSGDALEILTSFIFPSVWSDRSNRLYYVDPERRSQVLVDPTTNQAMITDKKSPFPGVFSRVPLPTGINRLAWEIRHLFTEKWTVRLAAHGVGSFKSQIKFNHLLGFLVSIAITTAYHLVEWHVLSNILGAAMCYAAFGMLSPTSFGIGTAVLWGLFFYDIVMVFYTPFMITVAKKVDAPIKLVFKSSSGFSMLGLGDIVVPGLLMALALRFDLYMFYKRQIQYQPIDASSEQASSTDQAATAMTETQFRRTKAPFVVSEGQWGNRFWTTKLGNLMPNPACGAVRAATAFPKPYFYASVAGYALGMVFTLTMLQVFNHGQPALLYLVPCVTGSVWLTGLVRRELKDVWGYTEDGSLDTKDVVVTLDTNGDEVRKPAADKDEKESKDGVKSEKETEKKEEETSGEYDVVLFSIKAPRPKPPKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPW4</accession>
    <name>A0AAE0JPW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_53024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686985.1">
        <property type="nucleotide sequence ID" value="XM_062828922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPW4"/>
    <dbReference type="GeneID" id="87866076"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="79"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="321" mass="36110" checksum="EF48BE5507F4CDF2" modified="2024-05-29" version="1">MTQQDGEWSQVSRKRGRIRHVPKPKTDVDESKENGLGIRPNPNPEFTVSDIHRHHDTARQEWQISDCWKTLKDLLVTALSESNHPPITKAICFGPGPYDPSNGSFAARRTAHMQTAAFCAIVDFLESQCEHKIKRVIQEPMFTQIDKDFCVELGFQVADTPDAFPMVDEQTLVYGIHMELRTYYLALATLPTAFIGGGLNEWERVIDFDPSLKEFIGPISKMDATYTKYPFPDMNYIFSSTTMYWRKGDDAPKIPSSRKAALSESPQASKQTSDIAEALEGLKLSEQASEENSSEPESSKPTEKPTELEGSKESKPLTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ60</accession>
    <name>A0AAE0JQ60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EPT/RTPC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_417920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686686.1">
        <property type="nucleotide sequence ID" value="XM_062824115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ60"/>
    <dbReference type="GeneID" id="87861269"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="501" mass="53583" checksum="58B0ED88C38CCA45" modified="2024-05-29" version="1">MAQPSSNPTCSGTANIILRSSADDPEHMLPHQRKAAMKKSKAARPILEIDGRTGEGGGQLVRIACAIASVITQPIRITNVRGNREGPRGGASIEWLARVTDAEVNGLSVGSTTLEFKPRESPATSKLFTGIHDRTVKIDADSAAASTLLIFQAIFPFLLFAGGNTNKRQDHPEHIDVEISGGTNISFSLSYEYLDQVLLPSLEQAFGIVVERKLKTRGWNLGKMQRGTVALRVHPIRVGDSLRLRNPTACTMKGRNRQGEDFDLEAIDVSIVAPTDMHESLSQALVQNLGDLFPDVEVIFKLLEDSGANSRIYVLLVARSWPSDDEGGAGSGAVLRWGRDILTSMPKAANSKKGKNKGDNGSSSHAGTGGVASMSESVATKVARALYDEVSTGGVVDEFLQDQLVAFQALASGLSAFPRGNSDPADDNVSGPGMEEAMAALDLTDENATQGLRKDKTTEPFGEGSLHAKTARWMVSELLPNVKFYNKGKVCEGAGFAVEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ69</accession>
    <name>A0AAE0JQ69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOP7</name>
        <name evidence="8" type="ORF">B0H65DRAFT_516756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ69"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000056">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="360"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="662" mass="75202" checksum="C92CDA6AFAC880B4" modified="2024-05-29" version="1">MPKIKKKGQAGAAKNYITRTQAVKKLQLSLPDFRKLCIWKGIYPREPRNKKKVSKSATASTTFYYTKDIQYLLHEPLLQKFRDQKVLEKKISRALGRGDVSDAARFERHAARPEATGKPRYTLNHVIRERYPTFNDALRDLDDCLSMLFLFANLPSTSAVPAKMIARCERLCLEFQHYLIVSHSLRKSFLSIKGIYYQANIQGEDILWLVPYKFNQRIVGDVDFRIMGTFVEFYMTLLGFVNYRLYSSIGLKYPPKFDQLKDENGAELGAFSLEGVNMATQGETKAVTNGEEQQGPDPKVQAEVDKIIKQLKEDESKSDETAEGDAEADDEEKPTDSIDKFEPVAPGGDVLPQPAYSSNDPSQLFANFTFYLSRETPRQPLEFILRAFGCKRIGWDSVLGEGAFTNDESDPSITHHIIDRPVVQAATNEDGDGEDNQTAQKVGPNQRYPGRIYVQPQWVWDCVNDEELKSPELYAPGAALPPHLSPFVKAAPGQYDPTLPLEAQQTEAEAIEADLEDAEKDGAEEGSDVENDMDVDEAEDDEEEEEGDEEDAEEAEEEDAEEDEEESKTLQRQLELEAELQGKKVQNKKVDPKTKAKLEQRKTLEKKAREEAEDLERAKGMLSKKKRKLFEQMQYTNNKKSAQDEKLRAKRRKLEKEKAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQG7</accession>
    <name>A0AAE0JQG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_544723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686851.1">
        <property type="nucleotide sequence ID" value="XM_062829317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQG7"/>
    <dbReference type="GeneID" id="87866471"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="17892" checksum="4005F19BEFF8712D" modified="2024-05-29" version="1">MFSVVKKLSAKVKEAFTLPGEGLLAFGAGASVAADPFGGLFVLPAPSSFAEPRASTTKKLSAKDKKKQKKKKKSTTRGTTKASKARKPNTIERPRDALPTWAGRAWARLPPPVSVLARLQPPLRAISGAGAGCSLRHQTPTPPPTPPPTIPSCRRAVWAAAGRHKTRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRD8</accession>
    <name>A0AAE0JRD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_453992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687477.1">
        <property type="nucleotide sequence ID" value="XM_062826177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRD8"/>
    <dbReference type="GeneID" id="87863331"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="313"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="999" mass="108721" checksum="D26DB20B5EA156B7" modified="2024-05-29" version="1">MPLEKTNPSTSPGPATRPVIGTGSRSVSVEGPPPGAAIPPNRLQKQQDQQQPPLNSSPTSSTGHSRGRSTSSQPPVAHHRTPSAEPPRIVSTSVDSRPTSTHSNGSDDSGPTAQKHKQRRSWFGGRSRSNSEVNKGDSNAAWIVAPDSKADYSTANLLNGEKVPELWNESGNLFIYLHSPESGRGPSFKVHDYLVSSSQRLLSEITGFNNPRKASAAGSLLTVDDATNRRPVPPPSAYGANPNDGHLYLPLENTSLDSLVAARNLFALLTSQPIIATNTYPTLFATLLQVAALLKNLGFRNHDGSTFGEQVDAAFNSFLDQFGVSDVRGSREKTIQAIILGEHMRSWTLYNEAFTHAVGKYESIQDLKLPIYNSVSVSTRNRLERAYLDLTNRQANANLRLESFEFPSLFAGIGSSTSSEEAKHLNFKEWQKSFGKMRTFVLSYYKDLFGNWPPKARSKKNQFSQSGLNRQCLKMLYSDCCALYDLLVDRESITPRVIDQKFDDGVAEAEAEREKAKNANEIEYELFLMRSALRTMLSEFDHSSPPVLPPIPFDCPKIPSMTAIHENYRELDAKKRAKLDRKLASNELLLMLIKSRNIDTDALQLPFLQAFKEFEHKEAKGVNPSDIANQRVGYWLFLYVVLQSLPMLVVDAPGLHWTEGVEYFLCEAPQGNPPWMEDAGEVRKMWYQTNNGQGIVELSADVVMFSVEGIYMRSHCWLAAKEWEATFLPASAAAAINQPLDAAAAAMGEGITPLEPPRPVFQDNDPFFAGHQRSGSRPQSSYVGGGTPGSEPASPHLRPRTGSPANRGVSAYRSSIAMGLEPLDFSQFGPNGPSSQQEAEFMQSLAPGGGQDRSSRVFSTPANIPSGGGRPDSSNSNGFQPAHGHRASSVGSAQTLAALGNLSVGESQGYNDGRSSAPPAAYRDPSRGSIASMNGQQVQQHPGSSVSPSPLGRGESPPRQSPPRQVAQPAPVPSNGGSTFDDILKGMEGQKKKKKGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRJ8</accession>
    <name>A0AAE0JRJ8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_555392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687517.1">
        <property type="nucleotide sequence ID" value="XM_062830026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRJ8"/>
    <dbReference type="GeneID" id="87867180"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="319" mass="37340" checksum="A26B494EAA507B8C" modified="2024-05-29" version="1">MTPRKQKVRVPWASSASSSPPKKTQATGIITHNTARARGYILDVYTLRSLSSARTTLGRRRPTKGHNTRQKPRMCLRVRVVYQCGCDATRAIPEHPDYEIWSCHEYTPSCYEYYERTTGLSCGYILANDCGRPTCKAVRNYWGWRVYNGLANQATWGSFVRCYDRWYDAGANNQLSPVVINHPHERAPHRWDPRYPRYDQPGFIFMTQWNQHQRMKNAEDALPPRWPVFDVPNPDLGSYYGNYPALNKRILEEEDPRPLGLEEQEVRQGPRRLTIGQTHLLLSRIRLSITPLNLQPYPHQLNFTSWWRCLFRHYQLSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJ33</accession>
    <name>A0AAE0MJ33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_80312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676503.1">
        <property type="nucleotide sequence ID" value="XM_062831438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJ33"/>
    <dbReference type="GeneID" id="87868592"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="216" mass="24145" checksum="D23C6F176F2205F6" modified="2024-05-29" version="1">MPFNHHGGQKAGLEPLESRHVNQSRSTSLVVRGGLICRTNLDRFPGPFLRPVGVVTMVHPQCRGWPTGESSWCNHSSATLGKQGVRSGRLGGACRSVLSHILPMRKNVIGEVVVVTRSRHQTLRYRTEDPEVETPRRHRPEDADTKVTRWSIQSSFVKRESLFKVSSPSLLLIAGHQGKHQGTPKVTQPQDLQSWEPSACPFDESGRSARPFCRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJJ1</accession>
    <name>A0AAE0MJJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_512760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676701.1">
        <property type="nucleotide sequence ID" value="XM_062828600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJJ1"/>
    <dbReference type="GeneID" id="87865754"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="550" mass="60054" checksum="88942EDE6146F440" modified="2024-05-29" version="1">MPRKTVLQSRLACDRCHSQKLKCPRQDKTTKDPDGTSKQPAACVRCERAKVPCVFSPRQRRTVIPKTAGASKPPPNRDIADSADATPASTGPALTKTTPTGPENGAINSVEGESASCRLENPLPSTTATPTDTQPFDATNLAQEFYGSSYFDNNQLDLQQSSTGSCTDPSTTCTDLCSLSLDTTTGIDWDNLLLPDPLPPPSQGWCLLDIDKSLLPAPAPDPLFPPHGPQLPLDLMTNSSPSDDLDPILFQPSSSAPVDYSNQQALTPYSPVRQLTNLNVSLYERLCLIPQIFSNCGLPTLTLVVRIDVLEKRLLAIDHIFQLTQELIDIVGKLYPRSVPVLSGDDAPTVPTTGTGVPLAQDQATVLLLLSCAQRVCDVYDLMLSHMRRCMKKNSLPHFPEELKPVRLPPFRVAGEYVPPTDKAVTLHMFMVMMMASNLFDQLQEVLGLWRHNEQGPHAGLELVDLQYPDFGREAKEAIRKKARDVTMEIVSIRQIIMSFPGMGMEETRQGILDLGSGGGSVRNGMGKVLGEARRLALEGCSKVWDGECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MK68</accession>
    <name>A0AAE0MK68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_446443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676879.1">
        <property type="nucleotide sequence ID" value="XM_062825796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MK68"/>
    <dbReference type="GeneID" id="87862950"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="312" mass="34432" checksum="9C08767A6BB7EE77" modified="2024-05-29" version="1">MALSFSPSQDPDSINGRLRRLMSRKRIRSKKEDKRRAVESPLPTTPIVALAKRHDPCSFRTRLSDAGLAPELGYYVAMATTTTPKASNGCVAVERSLGRPGEAPPTPLRATMRVSSRTLRSRKRSRQEHEDDGCTPSASAKIITVPSSILIVPSDEDGSDSLAPTPLSPGFDLIDIAFSTVEEFDDTEMVSWNDRRRDSGPINFDANMSTMRMPFSYQHPRGMRRSVVDMVVTTDSAGFGSDEWSVIADASMIPTYGPSDVMKQPIHQAIVRSFVSRCRAAKRRMMTSRRHSCRLSLTDMTAGQRVSVGAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0ML14</accession>
    <name>A0AAE0ML14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RhoGAP group protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_512647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677165.1">
        <property type="nucleotide sequence ID" value="XM_062828590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0ML14"/>
    <dbReference type="GeneID" id="87865744"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="373"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="700" mass="78877" checksum="F2905E8B13823CDD" modified="2024-05-29" version="1">MARKGVPQPLTLAESGTPGKETSPRLGDTTQRQQQAPSSSAVSATGSGSSLASGRSTPQASRSPRSPRSPFKIGLQKPESPGEPPRTSSPPTQQPVEAVAVSQDQRYQRQKSPEVPPEDHSRATTSTPVPSQSSDHQGHKHSRNDEDKSSKSSFFLSFGKPSRSSERANSPQLFESRTEDPSYNEYPSQGKSPTLPAKSEVSLISSNEYETANKNRRSKPKPFTLLSRTRSHKEKEKENQPNSREPVYAPARPGEPDKVYATSAPRTAPIQERTFRDMMVSGPRGHSAERAGGSKHFEGINRNQSISLKEAGGSLFNGLKESRAAGFLTKKLFGSSREDRFAPKEPVIDDEHYVLKVINLPLVEQTRLTRISKRLEDSRDKTEFWMPAFPWRAIDYLNYKGSDVEGLYRVPGSGPQIKKWQRKFDEELDVDLFEQPDLYDINIIGSMLKAWLRELPDELFPKAAQERVAKECAGAEKVPELLREELSNLSPFKYYLLFAITCHLSLLLAHSDKNKMDFRNLCICFQPCMKIDAFCFKFLVCDWRDCWKGCKNEAKYIEEEYALFDQPPPRSHRVTKRETELREREEQEDRERALQREREREQRAHQQQGGQVIPPAHRNGNAQQPAQPPPVQRLRKKNTTQETTQTATVDTGSTILTTITLVSDRDASPARGPNHQNRRQLQPGELPALSPIKPLSPMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMK0</accession>
    <name>A0AAE0MMK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">B0H65DRAFT_435219</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677478.1">
        <property type="nucleotide sequence ID" value="XM_062825182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862336"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000169">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2430:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
    <keyword evidence="14 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="31">
        <location>
            <begin position="1696"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="29">
        <location>
            <position position="1840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KAK3338027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2092" mass="232325" checksum="BA73C79088C0636F" modified="2024-05-29" version="1">MYGTGTGAQTGVTTPRSSASLRPLTLSHGSLETSFLIPTGLHFHATQLKERFAAILPAPTDELAQDDEPSSIFELVARYMGFIATEVAQGEDDAQGSYEEVLKIILNEFERAFLRGNDVHALVSTMEGIDEKKLEVIRCYYLARSASNRAIKPYESALFRAAGENAAKIFTIFGGQGNIEEYFEELRELHHTYPAFVGELITTSAELLQTLSSHPDAEKLYPKGLDVLGWLQSPEATPDVDYLISAPVSFPLIGLVQLAHYQVTCKVLGVHPGVLRERTSGTTGHSQGVVLAAITAAADSWESFEEHTKSALTILFWIGARSQQTFPRTSLAPSMLQDSADNGEGAPTPMLSIRDLPQAEVQKHIDQTNAYLPEDQHISIALINSPRNMVVAGPPSSLHGLNLQLRKLKAATGLDQTRIPHTERKVRFVNRFLPITAPFHSKYLAKASDLIAEDLKDVHIDSQTLGMPVYNTFTGKDLREEVEGNIVPSLVRMITGETVNWEKATVFQDATHILDFGPGGISGLGILTSRNKEGTGVRVILAGTVNGTVTDVGYKPELFDRDEEQAVKFAVDWVKEYGPRLVKNSVGRTYVDTKMSRLLGLPPLLVAGMTPTTVPWDFIAATMNAGYQIELAGGGYYNAKTMTEAISKIEKAVPAGRGICVNLIYVNPRAMGWQIPLLGRLRAEGYPIEGLTIGAGVPSIEVAQEYIETLGLKHISFKPGSGEAIQAVINIAKANPTFPVILQWTGGRGGGHHSFEDFHHHILNLYGRIRRQENIILVAGSGFGGADDTYPYLTGDWSIKYGYPPMPFDGCMFGSRMMVAKEAHTSLAAKQAIVDAPGLDDSDWEKTYKGPAGGVITVRSEMGEPIHKLATRGVRFWAEMDQKIFSLPKEKRVAALKASRDYIIEKLNKDFQKVWFGQNKEGKAVDLEDMTYAEIARRLVELLYVKDEARWIDQSYTKLTGDFIHRIEERFTTTPGQPSRLQSYADLKEPYSAVEQILSHYPEAEKQLINAQDVQHFLLLCQRRGQKPVTFVPVLDENFEFFFKKDSLWQSEDLAAVVGKDVGRTCILQGPMAAKHATKVDEPIKDILDGIHNGHIALLTRDLYGGDESKIPTIEYFGGKLIESEIPLDIEGLTVSYDEHKNTYRLSSSPSVQLPSLDAWLSLLAGHQRNWRFALLQSDVLVQGQKYQTNPMRRIFAPTRGLFVEILHPNNPEKTVILVKEQPRPNRYADVIEVKLDGKNEIVVNMIKDTTALGEPVPLTLKFIYNPEAGFAPIHEVMDGRNDRIKEFYWRAWFGDEKLDLDSSVHEVFDGGKTTITSEAINEFVHAVGNTGEAFVDRPDKVMYAPMDFAIVVGWKAITKPIFPRTIDGDLLKLVHLSNQFRMMPGAEPLKKGDVVSTTAQINAVINQESGKMVEVCGTITRDGEKVMEVTSQFLYRGTYTDFENTFQRKMETPMQLHLATSKDVAVLRSKDWFMMDDVENSDIELLGQTLTFRLQTLVRFKNKTVFSHVETQGQVLLELPTKEIIQVATVNYYAGESHGNPVIDYLQRHGSSIEQPINFENPIPLSGKTPLQLKAPSSNETYARVSGDYNPIHVSRVFSNYANLPGTITHGMYSSAAVRSLVETWAAENKVGRVRSFHASLTGMVLPNDDINVKLQHVGMVAGRKIIKVEASNKETEEKVLLGEAEIEQPITAYIFTGQGSQEQGMGMALYDSSPVAKAVWDRADKYLMDTYGFAITNIVRNNPKELTIHFGGPRGKAIRQNYMSMTFETVAADGSIKSERMFKEIDEKTTSYTYRSPNGLLSATQFTQPALTLMEKASFEDMKAKGLVPRDSTFAGHSLGEYSALAALADVMPIESLVSVVFYRGLTMQVAVERDETGRSNYGMCAVNPSRINKTFTEEALRFVVGSIAETTGWLLEIVNFNVENMQYVCAGDLRALDTLGGVCNAIKMMKIDIEKMRKEYSAETVKEQLVEIIKSCANDTEAKPTPLVLQRGFATIPLPGIDVPFHSTFLRSGVKPFRSFLLKKINKTTIDPSKLIGKYIPNVTAKPFAITKEYFEDVYRLTNSPKIQQILANWDKYQEEGASGIPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MML4</accession>
    <name>A0AAE0MML4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_581541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677523.1">
        <property type="nucleotide sequence ID" value="XM_062830823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MML4"/>
    <dbReference type="GeneID" id="87867977"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="355" mass="39155" checksum="EEF3152384E64DEC" modified="2024-05-29" version="1">MGLTGSGKSSFIRHCVGNNGIEIGRGLASCTKDVQIHSYKHSDSIEVNLIDTPGFDDDSLTDADVLEKISGYLKESYDRKITLNGLLYLHRITDNRMQGSSMKNLAVFKKLCGPDALHHVTFVTTMWDKESESCREEFEGREKELLTDNKFWATMIQPHGACTGRHNNTRQSAMDLLARFIQQPESTVVTDLQRELVDDKLRLDETAAGKVVMSGINKAAERAEKELRGNKEAREDLASAAREEKAAHKAEQEADTAELEAQWAELLAEKAELEAKLRKLKEQEEKLRKAEMESSKRWNCYFRVGCVLAVGSGAAVAAVASGAAVAVPVILKDTILVAAQLAMQLATEENETAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMW1</accession>
    <name>A0AAE0MMW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RAD55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_323318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677897.1">
        <property type="nucleotide sequence ID" value="XM_062823440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMW1"/>
    <dbReference type="GeneID" id="87860594"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="40"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3338446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="441" mass="48176" checksum="3603A23558EC83D1" modified="2024-05-29" version="1">MDYHERHGHDVASFDDLPSTHRMPTVSAADALDDLNDGDNSPFIPTSLDALDAALKPSLDIDIVTGGVQKGQATEIWGPPGVGKTAFGIQLAANCLSEGKGVVWVDGFHRVPIERLRSVLGSKVKKDKEEEEEDATVDERLDALTHYTCPSLPHLIALLCRPTPSCIPQNTSLIVVDSLSVLVNHAFPRTPDQKKVVDSKGNKVPSLSARRLQVLQYIIGALQKLAATRDIAIVVLTQCATKMMQAERGATLVPAINASVWEQGISTRLVLYRNLAFSDAKLQGLRLVGVQKLNGKASEAPVDTICAFDIEESGLVTVEYDFSEPLPNHLSTPSTKRKLGDTTLEIADSDDEDYGWQEEDDEAVPPPPSQWQGSEDILLVPEPESDQEDEEQEVEEEGYHEAKDAGDEDADDAFNTTADESQLASKVFGRDREIQDSQADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN54</accession>
    <name>A0AAE0MN54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FYVE zinc finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_579420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678078.1">
        <property type="nucleotide sequence ID" value="XM_062830759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN54"/>
    <dbReference type="GeneID" id="87867913"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="349"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="601"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3338718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="676" mass="75206" checksum="574C6FAD1EFD31C8" modified="2024-05-29" version="1">MSGRKLGGGRILGNGKGLAPPAASSPSASTTAAIHRAVSPFAPSDSSTVSFVSPNSTRDSISPSSSVPLPDIPQDLVSNVSLAGPSNGGQSAGANDNRLVCPICEEEMVTLLQLNRHIDDVHQELPEETQDEVKSWFDKQVRKAKKFQPLNIINQTLRGLDVFESNETQPVVATAASTTAPGRPAEKAVDPEELVTRHHWQRPTGNDPCTDPTCTRKLGPFSGLVNCRKCGRLFCEEHTMYQMKLSRSANHEPVRGIWCRVCETCFKSREGYNDHQGTVRDHMAEFKAIRAKRVDRHKLEVQRLEKRLTKLTRLLAEMPPDEGPGLLGLTGQKSQRKMIEQSVVSWEEDGAVTNCPFCKQEFRSWTFRRHHCRICGKVVCADPETACSTEVGLDVARPTINTEKPPGTATTTLDIRMCRDCKSTIFSHRDFAASIAHKPPDQRAYETLRQFERGIRMLMPSFQKALLALQPPNEDDYRQDKPPPTSAQVQEAAKIRKRLTDAFAKYDLAAKRLRDMKTNSPTQLRLQQSVYAAASAFLHANLIPLKSVPRVLRSNSMQYQHRRLLNGSTSTLSPLRNGESALTQDVETSSNAGASEASVVQSELDIEEKEAKERLVVLEEQMFMVQEMLKSARAQRRFEEVSALNRNVEELEAEIERAKEGVRGVEERMGALYIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN59</accession>
    <name>A0AAE0MN59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_499469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678093.1">
        <property type="nucleotide sequence ID" value="XM_062827826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN59"/>
    <dbReference type="GeneID" id="87864980"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF18">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="137"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="411" mass="45422" checksum="C3AF2494862C2752" modified="2024-05-29" version="1">MTADEPPSDSLTLWEKLSLTWLVPLFAARCIKCLLFQSNPSLHWRQNLALAHLKVRRTTYPAKYLHLQARRVLTGKAIEAYIAKHPNIAHTTVSVPLPPSSASDIEIKNVPEPVLHFLTPVNGQDDVGGSENNKTTLLYFHGGGYVNPLRAMGHMPFILSMHKACKAKQTIILEYALAPEHPYPAQLMQAVATLRYLLTDMSLSPSDIILGGDSAGGQLVGALLAHLAKPSPYAPAVQQWREGEDAFKAAVFISPWAFMQRPGDLFEADEKWDYLTPKQCGRYQDLWDAKVDEVWANLCGFSADDDRDAQDEVWGRVFGRDGRRAMVGKTLVTVGTAEVLLDSCRRFGRECVGGETVVVDRDTDLEKEVKGREVVTVECVGEAHVQPALDAALGYEEGVMMRVMLAWLGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN76</accession>
    <name>A0AAE0MN76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_552783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677766.1">
        <property type="nucleotide sequence ID" value="XM_062829916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN76"/>
    <dbReference type="GeneID" id="87867070"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="587" mass="66446" checksum="E792E73630839259" modified="2024-05-29" version="1">MADALPSTPPPRSPDHRESDIHDDEYESTQPLSLSSLGDDENHCKLNLSDLDGNVAWKNDTDPKEQHTSDLCIDLHVDTTKLLAIFRLHATILLRPLEKWTTLYLLVHPEWIQSIEFKPFGDNFISLHFTMTQPPTLVAPKAMQESHEPRPRDQGLFDSMKSLATLRQFTVYLHRLDLIPETMEQLALLPSVFSSSHPFGLLRTDEKLASFDVLFRGAPGEVIDLGKTAPPGTNHNQTLAEMAEETVAETTGVIPPPYPNDGSSQNAPGYSAPNDRKRRISESLSPCTTDRYHGAGEPSTSGGLQSLNQFSTPTDRKRRRTSELLSRSPTDKHILLAIRRVLDRTASLDVRVKQLEKLITECLNADNTCRYDSEQEEQIYGHINATVDERIDEHMWDVQRELEGELSRQTEEWVAETVDLAQEELREELRHEIEDRWDNDITVKMKKMVKVEVLKDMAQAVKVMKRARAYREDVKSTTRRRMSTTTASTQSTAASTKPILTKPIPTKPIPTKPIPSTTLNHSLPGASAFQAAIQDIQRRYSAKMSAEEIMRVMDHLEANLVEAVKYNGCGAELKWLYVQRWAAKQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP28</accession>
    <name>A0AAE0MP28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_296782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678681.1">
        <property type="nucleotide sequence ID" value="XM_062823093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP28"/>
    <dbReference type="GeneID" id="87860247"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="555" mass="60321" checksum="B8230D3F0D815F6E" modified="2024-05-29" version="1">MSTNISTQDDEPKSQHGIVFQDIECTAGGEGHGKHNDQVETTTRLRSLFWPNSLSTSKEGVVYDNHSKENPKWYQKLIDAYQKLIDAGVEENGIQPVPIEGRTSTQYNQLFTVFFTGLLCLLPVPTGMLATLEFGLSLRDASLIILFFALLTCLPPAFMGIGGMETGMRQFVQARYSFGLYLVIIPLLLNAATITGFTLMSAIAGGQTLAAVNPSHVSVNVGIVITCLVAFGVSLLGFHFVHFWNRWTWIPNLIALVITVGCGGRYLHLQSEPAAPATASQVLNLGSLIAGYFLTFGGMVGDYSIYHNPRGALRFKSFSARARIFTYLYLGLFLPSVPLFILGAAIGGAVPQVPAWQAAYASTGIGGVMMEMLAPAGGFGKFVMVVLALSVIGNIAISMYTISLNLEMLLPPLPPKVRVHRFVFILVTMAVMIPLAVRTAKEWQTSLINFLSVIGYWSACFDAVLILELVVFRKMDYASVDHAIWNVGRKLPPGVAALGASILSWALVVPGMAQSWYVGPIGKRTGDIGVEVAFVVTGLLYLPLRWLEIKIRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP90</accession>
    <name>A0AAE0MP90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_531828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678876.1">
        <property type="nucleotide sequence ID" value="XM_062828949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP90"/>
    <dbReference type="GeneID" id="87866103"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="24490" checksum="C435047A24E9DE39" modified="2024-05-29" version="1">MVVRLNRLLPRNGLFWRYYGFNSSILSPERRSEVVFQALELLVWEAHPDEDLKITSRQAKDTIEQLLVEVVDAATRFADTFAVPPNSWESRHLAAQGISDPITREVSDANAEEQRSFIERAHPTTRLGKELSLNVFAALFVAIVDAREIFLADERLAHQDPSRHSPLAQAVDRFKAAAWWWYKAKVPTDEQVVEEGEDSDDEIEDEEDEDGIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPJ2</accession>
    <name>A0AAE0MPJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_299005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678754.1">
        <property type="nucleotide sequence ID" value="XM_062823125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPJ2"/>
    <dbReference type="GeneID" id="87860279"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="67484" checksum="1840316CF1A3678E" modified="2024-05-29" version="1">MVYRQGLVAGIISSGASCPSELGSELGPNAANKLAPYQRSNIDINITNHYSSKVYTSSSPIVGDVTITTKRDVRFDDIEIILLGNTRTRTEGVNSPAEIAHTFLKLVMPIPSSTYPVPRVLETGRTMTIPFEFVIPNQLTIGACNHNVQTDQVRDQHVLLPPSMGKEWEKDDMSPTMVSVEYTIKARVFRQPNVGGKRIRIMEARKSIQVLPASPEEPPLNITENDKLYCMYKKKSLRKLLSTKVGTLTAEAIQPRAAILQSNGRTMTSTPMAQIRLKYEPTSSQQLLTPPSITNISGKVTAHTFFNSGTVPAFPNMGNWTADFSIDKRGVYSTSVPLRKISVVQPTWQQHHYSLERRDSGYASDFSRPRYQNNSEPGSSEGETTPGIGTETRRLIPPSPSPSPPTPSPLPKSSSSSSKKTKPTSPTFFTTTLPIPLSLSLPLDRRTFIPTFHSCIASRVYTLTLSITAAAGSTSKARSAGASTTFSLTLPLQVAVEWDSEQQEQQRVDGQGLPHFESLYGYGTSGGMMMGVNEEEERAAAEEHLRPRVIGLPPDLWYREREVRQMQRGSQQREREGFGSEGVTTGGGGGGGGQGQVRVRVAEGGRLPGYGEAILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPW5</accession>
    <name>A0AAE0MPW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_445374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678515.1">
        <property type="nucleotide sequence ID" value="XM_062825742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPW5"/>
    <dbReference type="GeneID" id="87862896"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="126" mass="14804" checksum="A945F5C8DB0D8F32" modified="2024-05-29" version="1">MPVLEQETASEPVPEQDAALVEQVKALMKQNAHLEALLEETKQKIDVMTKNAERAKKNYISEKKANNRKYEELDEFVGNLNVNHDATRKEVSDLNAAMHFVLEQGHEGKFFDKFWSKTREWKRYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ42</accession>
    <name>A0AAE0MQ42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_430742</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679776.1">
        <property type="nucleotide sequence ID" value="XM_062824898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ42"/>
    <dbReference type="GeneID" id="87862052"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="230"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3340834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="732" mass="81876" checksum="8B76199D54D921A1" modified="2024-05-29" version="1">MRPLARLASLRSSVSGQAFKSTLSTRAVTSRTTWTPATVSRISSTSLRSFSLSTPHHRFQVHVKKQNTKMTSTATTLKGQPLDKGVLESMLRRRMFFAPSFDIYGGVAGLYDYGPPGCALQANIIDIWRKHFVLEEDMLEVDCTALTPHDVLKTSGHVDKFADWMCKDPKNGDILRADHFVEDVLEARLKGDKEARGQKVEDKEEDPKRKKKKAKGTEAVKLEDAVVKEYEEILAQIDNYNGEQLGELIKKYDLRNPATGVQPEPPVAFNLMFQTAIGPSGNLAGYLRPETAQGQFLNFAKLLEYNAGNMPFASASIGKSYRNEIAPRGGLLRVREFLMAEIEHFVDPASNKKHDRFHEVADIELALLDRNVQLSGQTTVTKMTIGEAVKQKIVDNETLGYFLARIHLFLKKIGIDQSKIRFRQHMGNEMAHYACDCWDAELLTSSGWVECVGCADRSAYDLTVHAKKTGAPLVVRESLETPEIVEKWEPEINSKKFGPTFRKDAKTVEAAILALPQEELAKLTEELKANGKIVVDVPGVGDGKVEVSKDLLAIEWKKHTINIREYTPNVIEPSFGIGRILYSLLEHNYWIREGDESRGVISFPPAVAPVKVLIVPISSKAEFAPHVRRLSQKLRSVGISSRVDDSSASIGRRYARNDELGTPFGLTIDFQTLQDGTFTLRERDSTRQVRAEEAKIIDAIKALVEGSKTWQDIESELPIFEGQELEIRPAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ94</accession>
    <name>A0AAE0MQ94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_278433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679941.1">
        <property type="nucleotide sequence ID" value="XM_062822844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ94"/>
    <dbReference type="GeneID" id="87859998"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1217" mass="131720" checksum="EB80E2EA87E7EEF8" modified="2024-05-29" version="1">MNSIFGPAKAWFVSLPTSSPASDPEPAARSSSNSTSGHSHANDASSSSPKSTKPDDESSSDDDCFNAAIQDRLRQNPVQEIPKEEKVEDKEPFGGRFENMRAVHAKESKGTEDSDHATKSLQPAFPISSIKHDKPTSSNTQSNNYNATSKPSTNGSNKGEGTESEGAINLPVSQSASSTNRIGTPIARHSRETPSIVETGSSKRPLVVQDIEALSRSGSVDSAKRRRLSIGRHQTPCFDQLFSKDQRQRFKRESGSSHSRTRAPSRPLSKNLVSRMSPGSNLDKAKSKEIVKSIRDTPTTAGAKATEKIQQIKERAKEAQTPKRTEEQVVREFTKAPIESLFGGKPASNPTGTIVASSSQQNKAAKSIFGDKTASNPTNTIVPSRSQPTKDTRGTQGDKNQTSRQPATHRAAQATQPSLPIKKPSQPGDAITYEDHFKHIKDKYPQPKPATIVNRLPDIQQSSKENGRPLRTPTARKRNKPTATLASSSKNPPTPRTNINAGPTVLPSVPAPPHHLPAAPSAPEPAPAAAIPPPPPTKAVPAQSLLSPTDVILQYVIYRTDKYCPLTDPNTPHFRTKPVFISKKEANETCGRRVFEWIKTIPIEDFRNLDRQFMGNNLFQGTITYEDGDVQLYYVREEAKILGEVVKKRGLWLDEEGMGIYTKKMWAVWAVRYYSNGEEEEHQQQGQEGKHEGASSVGGGVGSGRVEVVDEGNEGDDEDDGEEDEDLLGDRTVNEQLNEGVVEVGEGVGQESSEGSGVMAGEGVDKTGEKISDDLDISVVQMNLDSQTEGHQTQTEPEIHTQQEVTSETQSKTQTQSENQSHASPQTQLEGHHRANIQGHPEPHKTGVEGHSGPQPEPNPPTNLSTPARTEHNVSNPTQPQTQPTKPPRPPTPPLPCSLYSPPPPSTIYSSSSESDTEHPSRSSRTRGRSLPNNIPPPPPPLPSSILLTPKTTHHGTFTTLRLANLEVLEVFKQLARPGTARYSDVYHWREEVLPEAERVFKEMGCNDDDGDNDREGKEEGGGIEKTPIKLEWVPDAQLFKWRFRKVEVWVEELELKGPKDLGGLEVKMPQGNSGNSGSFGPSGLSGSKTGSGSGSGSGTGTASSSSATGNGNVRAGTRTGTTVKVTTTSPKTAPDNTPTTHEQWKHYKNAQPVLAAKAKAKKRRRPTREEKGKGKAVDVDPVVTNKGTGNGAEQGIVDAWAAELGGSEDGDLSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQT7</accession>
    <name>A0AAE0MQT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-loop-helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_429704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680868.1">
        <property type="nucleotide sequence ID" value="XM_062824839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQT7"/>
    <dbReference type="GeneID" id="87861993"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="378"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
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            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="65"/>
        </location>
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        <location>
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            <end position="94"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3343075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
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        <name type="scientific">Neurospora tetraspora</name>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
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    <evidence type="ECO:0000313" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681036.1">
        <property type="nucleotide sequence ID" value="XM_062824808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRB1"/>
    <dbReference type="GeneID" id="87861962"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40781">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40781:SF1">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="256"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3343243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="425" mass="46477" checksum="EB78C07C71ECB840" modified="2024-05-29" version="1">MEETPWATPRPWRLTDCFMTPELLPHYLYYVRHGTSQTSFGPNGDIHTKNPDKRLAISSRGELKELVRRHLDWSSRGPSLFISTFFDKSVAWLWGSQREPIVVMYTISTRRLPAHWPVVCAGVHTQNAFDADFLFLSYIPSQAIVRVDTIRPPLPEVLAAVDYSVPPAAPTLQGFVPPPPYVGPYPTPHNQFAPTPVPAPAPPYITSTRPPPQYSAPQHFTSPPYTTPAQYITPVPPVGTPSRVPREPGNEAHPRSESSYPCETGPDPSPAPHFTSPPHTPPGQITTVQPVESPPQVPPQLKDGTSVSELPVSSVTEPSIASDPELDVEPKTELVPEVDSDLPATPKPKTPVDKPETPVNKPETPVQSNPERAVKSNPETPAGTKISFFAEDSELTSSPVAERAVNSNPDTPAPVETNINFFAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRS1</accession>
    <name>A0AAE0MRS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome oxidase c assembly-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_526725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680465.1">
        <property type="nucleotide sequence ID" value="XM_062828861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRS1"/>
    <dbReference type="GeneID" id="87866015"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3342672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="302" mass="32514" checksum="82E22EE2F3530B26" modified="2024-05-29" version="1">MAPPSNPRSVSDATRFTPTTPHASSKSADPRLNTPKGSPTGPKEPKMPGTPKFVETPEQRVARLRAAHLKAKQAQVSRMDRIIDGSRRFFDSAHKVTVLGLIGFTVMAGLVTAYTAADMMVYNKKRKAEFIEAQKKMEADSLEAARLAYITGKATEEQTALVEEYLEREREAGRPKPSIFSKLPSVIGAPTPITNETTEQTTTSVSEAATWPAATTPKATEEQPAAVDAATTEKSGLWGWLTGSLKKEDVAAGAGQQAPTLVGAVKQETSAIKEKAQAAFEKEKENQRKGGPLDKVGLPEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS35</accession>
    <name>A0AAE0MS35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_550181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680795.1">
        <property type="nucleotide sequence ID" value="XM_062829710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS35"/>
    <dbReference type="GeneID" id="87866864"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3343002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="18033" checksum="AC59CE6F39877EA7" modified="2024-05-29" version="1">MNPHQAKKVDIQSLSPEEQRLFRLYGKLPSRSDHFAKHLKERKYFDSGDYAMSKAGKGDGVDTGSVGSQHPVPENIPHLTSPGGGINGASGLAQAHHVVHQHSNMGPQAGSPVKESSYLSRGLSAEELETLNSSEHNAGAGQQQQQEQAAADAISAAPANQQEPIPIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS98</accession>
    <name>A0AAE0MS98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cellulase</fullName>
            <ecNumber evidence="3 10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_443946</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 10"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680990.1">
        <property type="nucleotide sequence ID" value="XM_062825658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS98"/>
    <dbReference type="GeneID" id="87862812"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041993894" description="Cellulase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3343197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="293" mass="30190" checksum="B8F13C482AB1ADD3" modified="2024-05-29" version="1">MRSSTILQTGLVAALPFAVQAASGSGKSTRYWDCCKPSCSWSGKASVNRPVLACDANNNPLSDANVKSGCDGGSAYTCANNSPWAVNDQLAYGFAATKLSGGTESSWCCACYALTFTSGPVAGKTLVVQSTSTGGDLGSNHFDLNMPGGGVGLFDGCTRQFGGLPGAQYGGISSRSQCDSFPAALKPGCQWRFDWFQNADNPEFTFKQVQCPSELTSRTGCKRNDDGNFPVFTPPSGGGSNPSTPTSPPSSGGGSGCTADKYAQCGGSGWSGCTNCPSGSTCKAINDYYHQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT83</accession>
    <name>A0AAE0MT83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_441955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683523.1">
        <property type="nucleotide sequence ID" value="XM_062825552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT83"/>
    <dbReference type="GeneID" id="87862706"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042247766" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20043" checksum="1005B648B1797EFC" modified="2024-05-29" version="1">MGDGGWGVWDFFCRLRCLLLLSAHAKSFGGEVEAAEPGAWGIGGWTALYGRQPRPDSSMIPKLPYLRSVTPEDMDLPRMHSTRMKLGCRITSMTATHPSVYRQCRRVPTWASAHFHIKAVQSKQSGTRRIVEIAALTSLNKSVMSRCAAAAGNLQGSRKRELLALPYRREPPDEPTMAAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTU3</accession>
    <name>A0AAE0MTU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related protein Rab7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_456257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684183.1">
        <property type="nucleotide sequence ID" value="XM_062826279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTU3"/>
    <dbReference type="SMR" id="A0AAE0MTU3"/>
    <dbReference type="GeneID" id="87863433"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="205" mass="23128" checksum="EFC8EBBAB6B89528" modified="2024-05-29" version="1">MSSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSASYKATIGADFLTREVLVDDRQVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFDALDSWRDEFLIQASPRDPDNFPFVVLGNKIDMEESKRVISTKRAMTFCQSKGNIPYFETSAKEAINVEQAFEVIARNALMQEESEEFSGDFQDPINIHIENDRDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTX5</accession>
    <name>A0AAE0MTX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_545505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683676.1">
        <property type="nucleotide sequence ID" value="XM_062829383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTX5"/>
    <dbReference type="GeneID" id="87866537"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3350381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="92" mass="9686" checksum="1ABD5662DDE3D36C" modified="2024-05-29" version="1">MRSRTKGSGQLWALSPGDVAGAWAAEKQIAAGLYVSLLARVQHMVPTAADVMAYMDTGVAGDMEAAASSFGAMEEGVVVLRERFALPKRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU51</accession>
    <name>A0AAE0MU51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_91988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683886.1">
        <property type="nucleotide sequence ID" value="XM_062831564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU51"/>
    <dbReference type="GeneID" id="87868718"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="502" mass="56629" checksum="0C4F5CA2B8EA8FD9" modified="2024-05-29" version="1">MAADHDAPVRDVPTTESSSVNNEKAPLPEYIENVALESAGWDEQRTKKLLRKIDSRLLPFLALLYLLSFLDRTNIGNAKLERLTQDLKLTGLKYNDALGIFFPFYVLAEVPSNMAMKRFRPSIWIPSIMVAWGICCTLMGVVTNYHGLMAVRSCLGLAEGGLFPGITYYITMWYRRHECGFRMAIFFSAATAAGAFGGLLARGILEMKGVGGYNGWRWLFILEGILTFVIAIIAFFAMYDYPQTAKFLEPEEREEIAARLKRDRSSLADEFDIKYFFAALKDWKIWVHMFITIGVYTGLYSYSLFVPTIINSIGTFTPEQSQLLTVPPYVVACLFCISAGWFADRLKQRGIFMMFFMGMAIIGLIMLMATRTPGVRYLGCFFLASGIYPNVPQGVAWNGNNIGGSLKRGVGIAMHVGFGNLGGVVSSYLFLSKQSPHYYQGFGTLLGCQVMAFVLSAFMTIYLRRENARRDREYKPPSEYTEEERIAEREKGDNATFFRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUM0</accession>
    <name>A0AAE0MUM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dehydrogenase FUB6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fusaric acid biosynthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_173490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUM0"/>
    <dbReference type="GeneID" id="87858556"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="28"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00083301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3348353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="358" mass="39070" checksum="2D430882F562D015" modified="2024-05-29" version="1">MFRHTHGYKSHSLQLELAHRPTGPIIPGHTFRVSAVPAPVPSDLNEGDLLLETLYISLDPAMRGWLDDVRSYVPPVQIGEVMRAMCICRVLASRSPKAAAGDVVTAMNGIREIGILSDRHIEKPAFLPPGGKTTDLLGVLGMTGLTAYFGMMKIGNVKKGDTVVVSAAAGATGSVAVQIAKIQGAKRVIGTAGNDEKCRWLVEEGGVDVALNYKDPEFRRKFKEATPDFVDVYFDNVGGEQLDMALARATRGARFVMCGGISQYNAEHKQGPKNIANVITMRIRMEGFVVFDYKDEYPTALGQLAQWLAEGKLKRKETILKGGVRVADEGMVKLYKGDNIGKMLVEVKNPDEERQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MVB8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_8772</name>
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    <organism evidence="2 3">
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685712.1">
        <property type="nucleotide sequence ID" value="XM_062831517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVB8"/>
    <dbReference type="GeneID" id="87868671"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="282" mass="29795" checksum="E09B913DE27EE86A" modified="2024-05-29" version="1">MSSDNNNSNQTNNDMARQQRRGSVTASSAALASLFRSNSISQGQPTNFPGTSAAINEQRRRLSITTLGLSGTSPSASFMRRASLSTNNSELAEENAIDEDDSARTAPAAPFGRRMSLGARGPRGGVSPGINGRPSPPTRNDSTSLRGPPPTPPPVSSPGIGNYTWGRTPSQANIATPLKTPSDVLSPRSEQGFNWSDQLRSRAESTVSGHRSSFSFASGLSGSPPGAGFRRPSPPASTPQHDRAKSVSDMPAPPAQAPKARPVPQKPDPFQERILKGDFYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVG6</accession>
    <name>A0AAE0MVG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 30 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_421521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685069.1">
        <property type="nucleotide sequence ID" value="XM_062824348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVG6"/>
    <dbReference type="GeneID" id="87861502"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042000527" description="Glycoside hydrolase family 30 protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="62339" checksum="4EA4AED1C3A8A547" modified="2024-05-29" version="1">MRSPAWLLFGIITSVASQDTGNHPDWPRWCGKVYKPDYPSFDPGGQTLPPTPDPLAPLLHVQFKPRYSLYLESEKTGDFIVNAEISQFHGTHWGNNTSSNVEFYIKTTTDDKVLVGDSIPVNSTGNLFTFNLSDLTASLSPIEVTLTYSAEGPSVKTTLLYLPSKTSGSVTRIDNLNGGLHHLNAASNHTFKPILPYGFYASYDAFLALPNYSEAIQSYADLGLTGMVPLTHYPESASAFAYMDSINLYYMFDLRENYTNQTWVKEQVIAAKDGEALFSYWSVDEPDGWQAPFSAPAETYNTILSVDPYHPVSLVLNCQNYFFEQYSQGADILMADVYPIGITDSSANLSNSKWGTPCNSTYGDCGCDNCAGSVLDVSNRFDDLKSYEQWLGLWPKTKMFNPQAFHGEGYWARDPTAEESWVMVLLAINRGVKGVLGWVWPASEILSKAHGRLARVVSSGEEEDGVVGLLVEGKGPEKLSTASEVKGVDAAGWVDKEGRKMLISVVNTGEEEVEGMVELEVPGGSRVGKVVWDESGGSGGDGEWEVKEGKLTKNGLKGMGTALVILELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVM2</accession>
    <name>A0AAE0MVM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_414265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685983.1">
        <property type="nucleotide sequence ID" value="XM_062823905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVM2"/>
    <dbReference type="GeneID" id="87861059"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041976833" description="mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="560"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="626"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="731"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3354605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="829" mass="92060" checksum="443A07E3C3FB6219" modified="2024-05-29" version="1">MRSHGTEASSLSARLITALLMTVSVVAGYDLDLSSIDSLKHAASFMAQDMMSFYSGDQPGGIPGLLPQPYYWWEAGALMGSLIDYWYYTGDTQWNDLIQQGLLFQAGPNSDYMPPDQTMTEGNDDQGFWGMTVMSAAEYKFQDPPSDKPQWLALAQAVFNTQAARWDTQECGGGLRWQIFTWNQGYDYKNSISQACFFNIAARLARYTGNQSYADWADKTWDWMVSSKFMDTQTYYIYDGAHTRNCSEVTPYQWTYNSGAFLLGAAAMYNYTTGSTQEVWRSRVDGLIKGLGIFFTGPRRNIMTEVACEPVNLCDLDQQSFKAYLSRAMAATTKWAPWTYYRIKPLLESTAIAATSTCIGGSNGRMCGLKWTEHGKWDGTTGVGQQMAAMELVLANMIQHVTAPVTNHTGGTSAGDPGAGSGDVGRTDPFSIAVPYPPISTADRVGAWIITAVMILGLVCGCVMMVLDEKSNLTTWKRLSTLRPDVLYACGKHWRPGHRKNGRGGGHGVDGHYDCNRPRFDIDDTCAFQSDCYDGGYGHIADVKEKDTVIELHHEYADNRHSWHGIPPPPPPSQYSARHSSSTTYVGSKSGSSGNGIGGDRMPPANKNIISNRLNHLNHRRSVLQKLHNQQQQQQQQNSNQTHVHQVPHTPLHHHHHHNYHNHRFHSHSHIDQTPYSAASRRHNHPSTQPSYYWDLDNTNGIDPARHVSQLSGMSALPGGVSGLVPDGATGFTPNPKRQLDQNRSEETSGIKVPAHSRTRDHRDCCHDGEREDGVTAGTGNGNGNGDVAIGDRINNWREADKERREKRNNRGGGNRFAWESSESVYWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVU1</accession>
    <name>A0AAE0MVU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_115900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684665.1">
        <property type="nucleotide sequence ID" value="XM_062820648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVU1"/>
    <dbReference type="SMR" id="A0AAE0MVU1"/>
    <dbReference type="GeneID" id="87857802"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3351370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="128" mass="13793" checksum="A641B09DDB17B9E2" modified="2024-05-29" version="1">MSGQNESAAWPKAEDGALVQELLDCVQQASHYRQLKKGANEATKSVSRGTSELVILAADTQPLSIVLHIPLLCEDKNVPYVYVPSKTALGRACGVSRSVIAVSLTSNEASDLNSKIRALRDKVERLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVY4</accession>
    <name>A0AAE0MVY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_3573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685579.1">
        <property type="nucleotide sequence ID" value="XM_062823669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVY4"/>
    <dbReference type="GeneID" id="87860823"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="318"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3354201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="539" mass="59680" checksum="30476F2C40D09D31" modified="2024-05-29" version="1">MGKFKISSWLNHSPSPSSDEDGKKQNRLSFSALSSSLSSKPKEPQSTTTGIHTPPPDEPEQPTSTSRMIVLAQKIAKETEKLETYMKENNLPMPSFDVDAPADFPKLPAEISKSRQEIIFATRELGLLAHGPRESLRWGVWEFLDVLALQVITHYGIAKLFPPTETITLSELQSKTSLDPINLARVLRLAMTKGIFREPTPGMIAHTAASRVLAEDGDLHAWIAFNGEDIFPAAAHVLEALKTHPEATSLTRAGFQFAFDTVDKEPMFVTFGKDPARARRMGKAMASLTGGEGYEVSYLLDVEGGGYDFSEIDAKGGKFVDVGGSHGFVSVDLAKKYKNMKFVVQDTAKTVESAPKPICEDEQVAGRIELMPHDFFQEQPTKDADVYFFRWIMHNYSTPYAIKLLKNLIPALKPGARVIINDHCLLEAGQENPWDETVMRRMDLVMLALLNAQERTEAEFRELFKSASDGFVFKGVTRPKGCRMSIIEAVWRPDLVEDGAAAAAITAATTAAEVETPTTDTLEEQLKVEELKLEDEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW22</accession>
    <name>A0AAE0MW22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_414319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686447.1">
        <property type="nucleotide sequence ID" value="XM_062823910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW22"/>
    <dbReference type="GeneID" id="87861064"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="232"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3355069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="594" mass="65275" checksum="0C4D37A079AE8607" modified="2024-05-29" version="1">MIINGSGAGRQPSSELVNGNKTEQSARHFHSNSNDVSALETLGPAAKLTDADPSEIPPASAPGRQNAVTINDILERRAKAGRLIAPTASYSDSDMFKGPQVGKPKSQSMDHHLSPESLSRHPCALKQAARHLKTPGLISLGGGLPCAEYFPIESITLKVPTPPHFSEAATASSGAEVRIGKYDVTDPLIQGTYDLSIALNYAQATGSAQLSRFVTEHTELVHNPPYSDWRSCLTVGSTGALEQTLRMLCDGPGRGDCLLTEEYSFSTALETANPLGVKVVGVKMDEQGLLPEAMDELLSGWDPKEREGRRKPHVLYTVPSGQNPTGATQGLERRREVYEVARKHDLFVIEDEPYYYIQMPLETGATTAAKEGEEGADGEGKEEEETVESFISSLIPSLLSMDVDGRVLRMDSFSKVVVPGSRVGWVTASEQIIERYIRHAEVCNQGPSGISQVILYKLLDEQWGHEGYFKWLMNLRGEYTKRRDTMVAAVEKFLPKEVVSWSVPVAGMFYWLKVDHTQHPGIQAGRTILEVEEEIFDSCIAKGVLVARGSWFRAEQDTEPNELFFRATFAAATAENMTEAIRRFGEAVRESFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWA8</accession>
    <name>A0AAE0MWA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_43069</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686687.1">
        <property type="nucleotide sequence ID" value="XM_062824896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWA8"/>
    <dbReference type="GeneID" id="87862050"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="103"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3355309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="510" mass="56137" checksum="AD0E606E00BC834D" modified="2024-05-29" version="1">MSSFLSNSTNQSKLQLATVALASAAVTAGAIYGYQQSRHGERLNRLKKSIPSSAGEAEPELQKVTRQGPVPKLDKEDEHNQALAHRAQNGDFDDELILEQLARNRVFLGDEGLAKLRNSFVVIVGCGGVGSHAATTLARSGVSKLRLIDFDQVTLSSLNRHAVATLADVGMPKVQCLQRRLIAITPWVRFDLRLQKFDGSVAPELLGAWEKDGQKPDFVIDAIDNIDSKVELLKYCYDNNLPVISSMGAGTKSDPTRIMVGDIGTSTDDGLSRATRRRLKLLGVTSGIPVVYSTEKMGEGKAALLPLPEDEFKKGDVGDLAALPDFRVRILPVLGTMPAVFGYTVANHVILKISGYPLDYIPQKGRDKMYDSIQAFVQASEEKIIRAVTGGPRELCIGLKVPIQPGEVSFLVEDIYKAKSAVTGIPTKLVLIRWQKPTRDILIRIGEGADEQKSSDLKLSELVCMTKEEATRHQKEVLLGEKTLEELYDAEVIERVAKRQEEIKLYEKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWG4</accession>
    <name>A0AAE0MWG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_420234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685385.1">
        <property type="nucleotide sequence ID" value="XM_062824264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWG4"/>
    <dbReference type="GeneID" id="87861418"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="330"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="504" mass="56695" checksum="5C2AB335B6C11ED8" modified="2024-05-29" version="1" fragment="single">MAGEGLSVSTPTEVRPPSSARPAGIGLSSQNASVAALNAPRPPTESGPAADCAESRLSPKWTFTQLGSALESDSLPENTQPSPTHAASDSSGSDDYDPGYTDNDDLCETCQFLVEPGPVCEGWEVEFHGKQPEFTFPIWILTTKITWSDNLMTSLFADYCPLCYELRWNMRRIDNELFQQQPTQDEITVVKQCEYRPNWNCFGIKLTVKTKSVDQFGLPVTMYARTEIYPESGMYHPHPRNSKCEEDFKVQLLSDRAIGNPGPFESNTGSDLTWQLVSSWMAKCLSSHQTCNQVQSAAPPLPTRVIDVGSKGDSRPPCLHVVTEKTSGRYATLSHRWASEEPLKLEVNNLQDFKQEIPLERLPKTFQDAIEATRRLGIRYIWIDSLCIIQDSPDGKDWAAESAKMTSVYENSYINLAATHAMDSTQGCFFDREPFLVRPIRLHVNWAMKSGYYYAAASHRFTLNVTVAPLYRRGWVYQERTLAPRMIHCSHTQLYWECLESIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWU8</accession>
    <name>A0AAE0MWU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_584928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686599.1">
        <property type="nucleotide sequence ID" value="XM_062830912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWU8"/>
    <dbReference type="GeneID" id="87868066"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="69" mass="8310" checksum="A4262016D43581C6" modified="2024-05-29" version="1">MAWIEFERDWTYQWSLVLQAKNLVDHRLSIGADTHALLYEQRWLRAAQPNCNIPWMFYNAVVMELEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXA0</accession>
    <name>A0AAE0MXA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_27292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686240.1">
        <property type="nucleotide sequence ID" value="XM_062822768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXA0"/>
    <dbReference type="GeneID" id="87859922"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="55"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>D-serine</name>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3354862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="440" mass="48181" checksum="4D7733A92FBE4424" modified="2024-05-29" version="1">MHLRFPTTTTLFLRPSSTRTSSPLIRSFVHRKSAVYYTTNPQETNSINMSKSKGHVVVIGAGVIGLSSALALLEANYTTTILAKDLPAPFESIDPRAQINFTSPWGGAHNRWVPPFPSPSPSSSSSPPLTPTQQAEHALRAREHALSLSTFHRLKLLQGQGQDQQAGITFLRGIEYLESPGPEYTSLTPQRAASQELGLPGPFRVLESHEFPDEKVKWGCEYDTWCVNPMQYCLFLLGQIIARGGKVFKREVRSVGEVFQLFSDSVQEFGATIPQADAVVNATGIGLGDDELVFPTRGQTCLVQEPCDATVTRQNADGSWTFCVPRGLSGTIIGGTKEPDNWDPKPDLKVRERLLRAFEGTYPKILAEGKTRLTPVRDIVGRRPTRKGGLRLEGEAVDGAGFVMHAYGLGGRGYELSWGVAEGVVEGIKGYLEKERGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZZ9</accession>
    <name>A0AAE0IZZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_81603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676540.1">
        <property type="nucleotide sequence ID" value="XM_062831448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZZ9"/>
    <dbReference type="GeneID" id="87868602"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055309">
        <property type="entry name" value="Znf318-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15577">
        <property type="entry name" value="ZINC FINGER CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15577:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="347"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="796" mass="90037" checksum="1EC14668535FF1EF" modified="2024-05-29" version="1">MRRSERPRRIDDSLRFNTYHSDRDFPSGPATAPLGSPRETRSHETRSHETRSHVGRLERDRDRDRERDRDRERPKPRLVESASTISSHYPSSRRRQDSLEHVPRHARTRSLSVPRSFSPPPSDDETPAQDSDEERRRLKARHTLKTKTREREHYPSGSHHRPSLQYYKNDRASLSSPRLAGWPSAGSRPPSRSPEPVRPKRMDRELRRDLFDRASFHQLNDDRDSLFSTPSEPNLRARLNIGVDDGHVGPGLVSPRKPSALARSTSGTGAFEYEGRQGGLSLRKPGTSSRAPSVAPSYRHPAPENAQYAEVRVLILTWAFHDLKVSDSDSHPYMFGPGSEFVSLEEETRRLRDTFESYGYTVDDWLIPMRDPLKAMLTKLAQFSKWANDETLLIVYYHGHGSLDERSELVFSSHEHPTDAQWAQTAAAELYAAILNQDACTHLGKPTTPYHELMKKYERYRPISKVKWSDIRSTILGINSDLLLILDCCAAGGANLDMEHSDATDTYHTEGPSGKIYTKHLFAACGFESSTSDDMTSAMCDVLDEWPGPDDAGLETSGMLVSSHGGGPSGHGGYSGKWLTTRKLHQIVESKLQRDAAMTAVGLRSASQPIFKQLLPVDLPERYITLPNLQGRRSSSRNQSRGRNRSSHHSQAASTADHDTIVGSAMNGGVEYGIDEGIPGSATQVGLGTARSRSRFSARDLSLGRISTRAERDRESGLRERDGSVRDSGRDREGSIRERERERDRESHRDRDREREERDEGWDVVSMREGLRERDGSVRESGRDRDRERERGRDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J038</accession>
    <name>A0AAE0J038_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_437249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676619.1">
        <property type="nucleotide sequence ID" value="XM_062825295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J038"/>
    <dbReference type="GeneID" id="87862449"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042151214" evidence="2">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="274" mass="29644" checksum="F954EE5DB56819D7" modified="2024-05-29" version="1">MKSLQALLLLAIAFRRAFGELTYSVTGTSHGKPIPPSDIVFKRKDPSLHRLNRGSTAESKTEAPTQPQNQKARRQSLANPIYYSDNWCGAVQSGNSANKVTSVHAYFQVPTVLGRQPGSVSSPPVDYVAAWVGIDGATYGGALLQAGVTSQLGTDGVQSHWAWLEWIPDAAYNIPSFPGNNIRSDSTSYNIPLVNGTPLGQVDAEWIVEAPSAVGYGRVPYSRFADVWFEDCSATTANGTTKGVDGATMYFWSSDKCVSFEYDNGDFWVQSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J079</accession>
    <name>A0AAE0J079_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_553495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676718.1">
        <property type="nucleotide sequence ID" value="XM_062829966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J079"/>
    <dbReference type="GeneID" id="87867120"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="281" mass="31054" checksum="8A6F9B9BEEBBE8EF" modified="2024-05-29" version="1">MSPPKHSLPIAHWAAILQQARIELELLSGETFTLPDETPWSVVVKKKGKKSKRKDKKKDTKKIGKRPAPDKSTSPSIHDNLEKSVTWHTRDVMKRRTTWNHKKKRVYTYTSLPKDFDIYEDTKALSKAEKHWIISGHRFHPQHGLEPIPEKSKLSLTKPRLPRVDPIPHQRRGPVAVVPAPITTGKSLWSQVAAKPAVPKVPVKPPVTKPSFAKVSAKPPVTKPAAVSEVPAKAPAVTLKKKMPPTLGVPASKVSPVPAATPKLPKLPSVDSTLRRQGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0D0</accession>
    <name>A0AAE0J0D0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_561649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676695.1">
        <property type="nucleotide sequence ID" value="XM_062830179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0D0"/>
    <dbReference type="GeneID" id="87867333"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="455" mass="53767" checksum="A083CA7249923532" modified="2024-05-29" version="1">MDKLPQEVIDRIARHLFPRAGSNTKQRDSLSAATYATISLLWQRAIEKKAFTLVKIRSPEDDLMLRQIMVRNPHRRECVRFIKYNIDLDRPERVTHFPFARDRYLVSKVRNIIELVNLIRIKDLPICPAVTQLQITYDEDINLRLTRPRRNFYAKPSDIPPVWIAGILPKFPSAENFVWELHEILDQGQQRTQLRTEPEDPLNVAIRTLSQQLDSLQVIGIFTATPDLFTSYKVQAGDKQPYWPRLENLYIESTNWTYNGRWYIKANNLTMLYHINDFLRNSTPEFNSLMVAVSQGMLNMPKLQKLDLSFRFPRFDTGGPIDKYLFEDAHGDYCNSLLFHVIRYRRASSEWLELADCKAAGQTYCNLDLFNCERRHKYGPGKFDVQPIYWRPFPDQAIRNWNTLHRRIKGLTPLLEWRSPYANPELREVEPREGIWPYAEKEKRKRSGLPWWRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0W0</accession>
    <name>A0AAE0J0W0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-coenzyme A transporter 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_335704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677039.1">
        <property type="nucleotide sequence ID" value="XM_062823565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0W0"/>
    <dbReference type="GeneID" id="87860719"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3334873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="588" mass="65500" checksum="44786043F1F1540B" modified="2024-05-29" version="1">MGTKTRGTKSPTQNGLSRKASKEKKGNKTQIKDSDSDPDTVASGLHKMNNNVELMRRNKSYDTSSEAITANIIGRETFSLDDPVPDKTDQVNNHGFFELPKQDQRNFGLLVLLYFLQGVPLGLATGSVPFLLKKKLSYAEIGVFSLASYPYSLKLLWSPIVDAIWSPKVGRRKSWILPIQLLSGIGMLYLGSRVEGLMDSMGKEGGPTVWSFTWWWFFLVLMCATQDIAVDGWALTLLTPGNVSYASTAQTVGLTAGQFLSYTVFLAFHSKEFANRWFRTEPLDQGLMSLGGYLTFWGWAYIAVTIGLGLMKREERTKNEDGVWDVYKIMWGVLNLKNVQTIIIIHLIAKIGFQANDAVTNLKLLDKGFGTENMALTVLIDFPFEIMLGYYAGKWSQEFTPMRLWCWGFMGRLVAAVLAQFTVVMFPAEGVTSWYMLVVIAEHIFSTFTNTIMFVAVSAFHARISDPVIGGTYMTLLATVCNLGGTFPRFFVLRLVDYFTTATCVPTSKTATFSEPFSCAIQEDKTRCLANGGTCNMIQDGYYIVNILCVAIGVVTFTMFIRPKVIHLQDLPLKAWRLASSGVGASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1F0</accession>
    <name>A0AAE0J1F0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Indoleamine 2,3-dioxygenase beta type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_437333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676552.1">
        <property type="nucleotide sequence ID" value="XM_062825305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1F0"/>
    <dbReference type="GeneID" id="87862459"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3334386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="570" mass="62560" checksum="F36B150C874F6013" modified="2024-05-29" version="1">MSSCEPLPTSAASKQKASSESESDSDSSFPDHIQSLLNKYDVTTNGFLPEGPPLEVLPDEYYAPWEELIGRLPESLDAGTFREEADRLPILETDRLKTEGEWRRAYVVLCFFAHGYIWGGSRPSEILPPPISIPLLAVSSHLDLPPIATYASLNLWNFRCVPPPSSYLSGLLPPSPPLTPASSSSSPSLTSGSQQPTCAKFDPTDLSRLQTLHTFTGTPSESWFYLVSVAMEAQGAYIIPTMLRALQAIGQRSENWKETTTKALRELVKCVDAVGELLERMYEGCEPMVFYHRIRPFLAGSKGMSAVGLPKGVFYDLGPAAEGLGEEGEERVQGERRKGKWMAYRGGSNGQSSLIQFWDLVLGVEHVSAGNSSPHSGSGSGSGKKKEQQKLKPFHEEVREYMPLKHRQFLSLVSKMGRGKGGIRKAVMEMVEAAEQEGRELDGKESELQKAFQDATRALAGFRNKHLQIVARYIVIPSRQAVPEGMVRKMMGRGGGRGSDMEGKERKEEQRERVVNLATASSGLQLRKEGGKEDVKERAGPELTGTGGTALLPFLKQTRDETLKAGEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J798</accession>
    <name>A0AAE0J798_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_581109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677291.1">
        <property type="nucleotide sequence ID" value="XM_062830809.1"/>
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    </dbReference>
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        <source>
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    <organism evidence="1 2">
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J7Q7_9PEZI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677875.1">
        <property type="nucleotide sequence ID" value="XM_062828557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7Q7"/>
    <dbReference type="GeneID" id="87865711"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7W9</accession>
    <name>A0AAE0J7W9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">Hikeshi-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_314878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677653.1">
        <property type="nucleotide sequence ID" value="XM_062823351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7W9"/>
    <dbReference type="GeneID" id="87860505"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="23227" checksum="FB4D8BFB10CC18B6" modified="2024-05-29" version="1">MSQPLFGLVPAGQPVIITPTEAPSPTSFLYAIPPTNPNSPPGSAISKPFGHVVVFLLPGVVLPPGTAAAIYLVTPPSPALGQTTPNFKFLGGIGPGKESAIFKVGPGAGTTGPGSKNVVIGVSVEDAESVASRMASLGTTTPAAATSGNGTEGALVPVSAERQQPSTLVLAQRIIKNAFNFLSSYTGSTPGQMEVVPLKAFEEWWKKFESKVRTDPGFLERDDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7X1</accession>
    <name>A0AAE0J7X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_512395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678044.1">
        <property type="nucleotide sequence ID" value="XM_062828570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7X1"/>
    <dbReference type="GeneID" id="87865724"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="131"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="383" mass="42392" checksum="00EDEC3E321D31D5" modified="2024-05-29" version="1">MSNHFVFNSPPGPQSPRSPMASTFHTNTQTLPSIGPRIPTVGPRARDLHYSIRDFLSAHPLLELGGQEHFTVERRRHQEVFGIHALPKDRIHPIDDVEFTAIRGPHGTIPIRVLYPSSGKDNRNKGRAGALIYFHGGGYTVGSVDEFENGLRLVAEESGCQVYAVEYRLAPEFKYPVQLDEYSAVIDWVQVLGGGDSAGGNMTAAICLRRMDEGRKPLAGQVLLYPEARLPFDTPAATEINSSLYLECNGIFGFASNYLPRSEDISPHDRYISPGMQSVEDLRGQPPAAVFTSGYDPLRDVGCEYANKLSQAGVQTRWRHYDNLTHGWLQMTAWSEAAEQAVKDVAQEVKRLVFAASNTHTPRTPQGQSQTWNSGDIKFAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J838</accession>
    <name>A0AAE0J838_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_551583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678162.1">
        <property type="nucleotide sequence ID" value="XM_062829826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J838"/>
    <dbReference type="GeneID" id="87866980"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="462" mass="50437" checksum="17CDB0B89B14440B" modified="2024-05-29" version="1">MPEATVTELPETSDRTPERGKTPGMHMGVGHVQIPTIVVPSPGGTNRIPHSGDWSGKKEEIHPQVKRVRDMSDLKKYILSWDWLAVLVQPTRLQGTTSILTHRQVVYDIQSIPQPDSYPVMLLRAQYPDLHDPNGWNCRVTSGRLGNAVDPVCGQCIHDCSRGRYPQPGLVRFAADGFAQSSTASMAQQLPSPYTSTWSDTSQAECTCLVWQPGTSKCSGFEHLKNKPGHSTNNGYRNYTLSVGGGRSHQAHISWLFLQPHHHSDQPPEQLSQRQQLSQPQQLSYYHNGAWANTPLSTSYRGGLDGAEDNLDLALFEAHRSWYASVSEANPSRSQGSGVTTARTGSTANVPNGTHRSAAVWDLSGYQGRNDSGYLPSTSSNESNQGATAPSTSTQSFEQPYAAFMAQVPRTQTWNAAPSSVAAPALDGNNDSQEIKQPCPRTKTTLRSPARGTASFPRITAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J884</accession>
    <name>A0AAE0J884_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_541695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678160.1">
        <property type="nucleotide sequence ID" value="XM_062829181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J884"/>
    <dbReference type="GeneID" id="87866335"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="149" mass="15981" checksum="A5F4BBA5817C054A" modified="2024-05-29" version="1" fragment="single">MARSSPVTVQANHPIHPPISCTTCLFLWGRRSYWAAWAPPLLILYSLVSRLVWTLVAVPMPRLVNQDCPLSLPPIRPPTGPTPTCQAPRHRTSPHNPTPPRPWRPAPVPSPAGPSPAASPLESKPPCPSRSRSGPCTAVVPALAAPDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J923</accession>
    <name>A0AAE0J923_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_474768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678238.1">
        <property type="nucleotide sequence ID" value="XM_062827268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J923"/>
    <dbReference type="GeneID" id="87864422"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="203" mass="22383" checksum="E61ABF0B5F22E863" modified="2024-05-29" version="1">MSNTTTRVTAGQRRAAGHPQSRQSEPHERLLEGHVQIPTAAPPSVLFSELDHYKIALFTRLPFLVIIVDPLLSLCGSCATQKAQTRSSTAQHVPDAVVQRSCTSTPCLFEVRLVQSTYLVDICTLAMVSLTPANEERGEAANGVSNSQPGIFLSFFFLSHNGNNQTQAKWPKRRIAEVRTEIGLVPFLEVRNFDGDGCRKVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J982</accession>
    <name>A0AAE0J982_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_433662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678311.1">
        <property type="nucleotide sequence ID" value="XM_062825083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J982"/>
    <dbReference type="GeneID" id="87862237"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="128" mass="14454" checksum="B246C26F79C8BD29" modified="2024-05-29" version="1">MCRTTVYEIYCADCNRFMREHRGREYCEQVDEYYRKGYRSGLESSASWPDGYGSTDLASNKMCTHAITRTKCPGCARELKTETKETKCSDATANNKSWGKCKNGGSTTESSKYGDKHCSSCKCKKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9D3</accession>
    <name>A0AAE0J9D3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_591744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678839.1">
        <property type="nucleotide sequence ID" value="XM_062831110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9D3"/>
    <dbReference type="GeneID" id="87868264"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="446" mass="47971" checksum="A0F5F8EF1E51DF0D" modified="2024-05-29" version="1">MPMGGDGPGAITVMWVMVSLAGLCVSLRLYVRTFIVANTGFDDHAYVLAFVFLLCYTICSTIAAHYGFGQNMWDIPVEDVPGAIMWEAIGQCFAVLGMAVAKWSLGLFLLRLVTQKWHKVSIWLVMGALMGASISVCFVFMLQCSPPAYLWDKSIKGGHCDLDATPVSMTLCILCVFADFFFALMPWIFLWKLNMNQREKMIIAISMSLGVIAGACGIKRTIQVPSLSSSNNYSRDTVGLIVWSSAEIAITMICIGIPVCRPLYKSFFNKIISSRNGTSRGYQKQSGGGGGATGHVGLRTIGGGTIPGRSGNDSKNKSKNNSRPLRDDESDEFELHREGKMGGMRSSGSDGLGTSPQGQSPFNDANAVGGSSASVAVGGRVGGMDNRSEESILGEDYRRGHGQQGSGDLERGEGPGQGGHYGNNRNSGGKPVMQVQITEEWHVTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9H8</accession>
    <name>A0AAE0J9H8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_432479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678765.1">
        <property type="nucleotide sequence ID" value="XM_062825007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9H8"/>
    <dbReference type="GeneID" id="87862161"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="397"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="616"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3339405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1177" mass="132298" checksum="1E34B0BDC41F491B" modified="2024-05-29" version="1">MTSSHHSADATTDPLKRLKRKRASTEPEASTEPGHDASAFAGNPSCDSQESSGSCGPATTGPKKRRGRPPKLVSEPTIVESNIEWPAWFKELDKTHRALNLVYTFCSTRKHLATTFETIRSTVESHTKRSLTIEDVAAIVALRPEGIQFAYVDELMLQLDARGAEKDDTFKTGRYAGKSSQSFAPDASVGGMTGLEGLGDAGPYHTGEDEQESKSGREVLYFEFIDEDLKRQVQDKKTGDPTKPTRRLRHEDVKMPVYSQKQMTALIEKRNTKFANAVNIFLNRCAAESLDPEMALISESEPFVPRPSTPRASTPQPKPSTLPASIPKERKSIPEIVQELKDSPWYTGQIVPDGHRVFEAQEPVYGYLNFLLSQDLVNALYNTKGITQFYAHQADAINALHDGHHVVVSTSTSSGKSLIYQLPVIHALEQDRNTRAMYIFPTKALAQDQKRSLKEVMSFMPGLEEMLVETFDGDTPMHDRNIIRDDARIIFTNPDLLHITILPQEERWRTFLQNLKYVVVDELHYYNGLMGSHVAFIMRRLRRICAAVGNTHVQFISCSATVANPKEHFTTIFGVENVKLIDFDGSPSGRKEFLCWNTPYKDPGDPSSGRGNAKFECSRLFCELILRGVRVIAFCRVREHCEKLVNAVKQELEHRGRSECISRVMGYRGGYTAQDRRQIETEMFEGKLMGIVATTALELGVDIGTLDCVMTWGFPYTIANLRQQSGRAGRRNRDSLSILVGDSFATDQYYMQNPDELFTKPNCELQVDLENMLVKEGHIQCAAYEMPILPAKDSRYFGDDLATVCEERLLKGDRGFYHCHDRFRPRPSQFVSIRDTEEDHFAIIDVTNNRNVVLEELEASRATFTIYDGAIFLHQGNTYLVRDFNPDKKMARVEKVKVDWTTEQRDYTDIDPVETEAIRRINGSKSLAYHGAIKITQVVFGYFKVDKKNRILDAIQVDNPPVIRYSKGTWLDVPRQALEILVSRRLHVGGAIHAAQHAIMSLMPNFVMSMPGDVRTECKNHLKEFARRETQRKRPARLTFYDAKGGAGGSGINTKAFEFIDTLLRKALGRVLACQCREGCIECVCSELCKEANSVISKAGAEVILKSLLDEEIDVESLPMGPEETSPAGVQTVVLAKPVPPRNRKTVKIIGLAGEEIEIQVNGERDDEEEEEEEDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9Q4</accession>
    <name>A0AAE0J9Q4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_304083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678940.1">
        <property type="nucleotide sequence ID" value="XM_062823187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9Q4"/>
    <dbReference type="GeneID" id="87860341"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="177" mass="19278" checksum="AC8C0F556722E949" modified="2024-05-29" version="1">MDSRKLFQMVQHNIHSPLPFLCPHLLSFVLCHKANEYPKYNDTMACTLSLSGTMALAGIVALTLIPTTSPFLMVLVATGFKLCQSIHSFGATSSQADSHQATFPSQPFKSLGFWMLTGSGFTSAQNPGTYSSRPEAPCAFKRRQVVAGRRDARRWNGRGGGLIFLVSSCSCPAWTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9S6</accession>
    <name>A0AAE0J9S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_248939</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679032.1">
        <property type="nucleotide sequence ID" value="XM_062822437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9S6"/>
    <dbReference type="GeneID" id="87859591"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="120"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3340090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="492" mass="54967" checksum="22D9E49311543456" modified="2024-05-29" version="1">MTGKGKSRWADSAEDAALEAQLKKEKEEKKRLKAEKARKAEAEKKKREAEAAAAQRQHQQQQTGDDDHVNGPPAKRRRLSPDRDAAPPQAAPTTASSNDSSKLLRFEGGRFGKCRSVENYDKLNDIEEGAYGWVARAREIETGKVVALKRLKIDPKDRSGLPVTGLREIQILKDCSHRNIVQLKEVVVSDDTSKIENIFIVLEFLEHDLKSILEDMPEPFLASEVKTLLLQLCSGIAYLHSHYILHRDLKTSNLLLNNRGQLKIADFGMARYVPDPPPPKLTQLVVTLWYRAPELLLGAARYGPEIDMWSVGCIFGELLTREPLLQGKNEVDELTKIFELCGLPTDESWPGFRRLPNARSLRLPSSSTKPAPQTTTTTLIRAKFPLLTTAGVSLLSSLLSLNPSKRPTASDMLEHEYFRQDPKPKQEAMFPTFPSKAGQEKRRRRETPNAPQRGQKADGSMGQVDFSSLVGGIFGAGREREERGGGFSLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA62</accession>
    <name>A0AAE0JA62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal L28e protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_550755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679227.1">
        <property type="nucleotide sequence ID" value="XM_062829764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA62"/>
    <dbReference type="GeneID" id="87866918"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3340285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="149" mass="16043" checksum="8ECB2E7C28E5C4C3" modified="2024-05-29" version="1">MSLSNVSADLIWEITRSQNSYLVKRTSGGGVQFSRDPLNLTNKHSRKYAGFVNDKAVGVVPGEKGGVVVTTKKAGSITKPSARYTRAFGANKTARKTYKAIARQVANYRPDLLKVAVARASAIRRSQRAVKPEPAQKLRGNAAKKAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAE3</accession>
    <name>A0AAE0JAE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_577934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679285.1">
        <property type="nucleotide sequence ID" value="XM_062830711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87867865"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1492" mass="160631" checksum="7A597E23EE528D5E" modified="2024-05-29" version="1" fragment="single">MDQTSSKKSDTMDKTRGTLKKSILAIDLGSTALRAAFVECEAPYNYIPIQNRNAQANQDAGAPVSGMGDFPVTCCPLDPNDPFARIGADAASEPGHVSAKYLMYILANVDDSVLADYPLPADLMTLKEDAQLREDCRTILAVLFGRLRERVDEYTKRRDLYFDEIILTIPSQWDATFEAIYESIVKEAFAYESKDGEKIEKNVHFCGEADALARYIILHEEKELDDWEVVLFLDFGGHSMSFATMELKRTKNTGGSDNSNMTFLDLDSGGCAGGSEMWSHQVGQLISEKLRETGVADANERKKFKLLSYFNSKKIGLMDQIREGGVLPLVCWDEHATLTTINLSHEEIKRCFDTALERPVAMAKEQLRKLKGYSGDKKIGVVVAGGTLKSNTAREAVFADCDIPENRIKYTTEIDVTWLSSCNCHGAALAHAKKMTVAQFFEQGAVIALQQKGPERNAEWEGFAYLLVGNDKKYVASVYNRKTGAEFKLVCNPNYAQKVTADKNEQDNAGEAGTSAGSVTNAPDNSDSDPNTNFIIPIEECYDLWPLGPQLAGRVIIEASLTSPSGTASSERTLHISISRKSQRAGPGDKVIDLPLFLDPGHNAVHVDVDALGPEASNQQAALRQREEEEAKPEHATTEAPSEQGSGVRPSSSNKSATAKASRTKRKRKDTNAAPAQPSKRLRTRADLGSDHEFQQIDYYAPPVQRKRKATAPASSTATKKARIATPAPQPNTHQIPGNQSDEDLQGQLQEQLSRESNAAQDDEQIEEQPQECSHTQEVPQHNDEDTHVHIDDQLDNELDKNHEPAATASGNHTQPPPPPLSPERSSSNNLNVNGNNNNNLNGNNNNNLNGNTSSSTRTRTAANARGATATRTRSHTPAHADRPATTYTNGRFAPRSSPPKRHRTEPLPEQRGQPQPRRSTRQQKGKSPVVASPAATRQQQQQQQQQQPQKGQEDPQPGPQHAPRPEQEARPQAGPSQAQAQAQNEADDTTPPATAADPNTLQQVATTVLAYVATHPHLPPRPTRIRQPAPEGNREDEGVILDSITVNPDPDDPQADQVNVDEDDQVDDDDKEDDDEDENDGDGGDDGDGDDDGDDDGNGPGLPDLANGEGAQGKSSSSVQNLRGESSGSGSGSRSGSANGRGHEDEAEEGSVGEEVTLRGPVPFSRLPRFQARASASPQAQGQARGERGNRVNAAERNKENQRQQTTGAGTGEESRPRPSREEKGKGKEVVKPAPKPAPTSTPTLALRAFYGQTSSAAASSSSSASAIPNTAPPSKPKGKAKAKAKGAEILAPLSRTALAALIESTGPTGPTGSTAPTAPPPIPPRPKPTDKGKGKDDVVVQTTPIPLPRYASASRAGRGVDGDGTEVEGGREQVVDVDGDEDSVEYGSRVLRSGIRGDNNSKGKGKEREEVNQTAGESSRTGGSNANTPLTRKRARIGIEDLLSSPLQRQPQPQEEDDSSPARKRQRTGGGGAGGKGGESSNAKKKRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAU2</accession>
    <name>A0AAE0JAU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_498531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679604.1">
        <property type="nucleotide sequence ID" value="XM_062827813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAU2"/>
    <dbReference type="GeneID" id="87864967"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31348" checksum="606A42D3F2F3E366" modified="2024-05-29" version="1" fragment="single">MSLNLKSISPLKRAWYKWKAIKFPWRNKLLTGLDLAGNAYYQFRPTRSTIRWRRIVQYPGGRSTHFSDVAVPPSWHQWLRYTREDPPTIEEQEAEVARQERIKVLAKMADERWEAKAKYIPDSPGEPSTRTIGKPGEEYGQPVPPVVGEGMKKSSPYTEGTSGGVVSGVETSGVSNQAGFRSEEAKQAAKEEQEKIRATAMETATKTATATVTGASSATAHATPADQTSGAREQTWDQMMKQQKQQKKKGIDPWKQAQASNPSGEWQPKAWDPSANLSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBL0</accession>
    <name>A0AAE0JBL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_429999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679618.1">
        <property type="nucleotide sequence ID" value="XM_062824856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBL0"/>
    <dbReference type="GeneID" id="87862010"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="655" mass="72242" checksum="3D62DA12717B234A" modified="2024-05-29" version="1">MEPFSPEAPHCNGASSSSSPAVSSDSPGTATSSGTVRNGSVATTTSQPSAPPPSVPAACLPCRTKHLRCDGSHPCGRCTATGIVAECAYVASRRGYKGPRRNPNNPTPGANPNKRHASSSPPYSGTTPDSCPMMLGHAPVTMATPSVHAFNPSIVLSDQSQLSFPSTPSVASIPVYRNNYMMDSTAMALATQAAPPIQPPAATLPERCFEAFYHYFHAGHPFVLPKRNLLELLKSNSEPNLSVVMAAMRYIGSLYVDAGPAKARFLDEAIQLCYAQGVRKDGFLIQALLLIIIGLDGSCEQAKARELLAICERYAIEIDLNKREFAVMHGRGDPIMEESWRRTWWDLYICDGMIAGVHRVTNFLLFDIMTDVGLPCEEEEYHKGCIPSPMSLEEFDDKEFLDEDREFSSFAYRVAAARNLGRLMRMPNVMFPDAAEVDKMEAHLSNWRMHLPDNKRDDLDPNCQLDEMMFQAHFITHACTIMLHQPLSQLDSSPVQAVNSCAPHRPVRSGDQYNAHTKHTVTAAYEISKMVTQAVPVTSHTHFFTCVVTLSSIVHLSKWALYMIEDEADLRQQIRLNIGALNKLSKVWKAANTAWGQVKGVAQEIYRQKKAQQITPAFWVGYTQEQMMTSIQADESIMNEFNQGLIAQVGVTQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBM3</accession>
    <name>A0AAE0JBM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_430261</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679646.1">
        <property type="nucleotide sequence ID" value="XM_062824870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBM3"/>
    <dbReference type="GeneID" id="87862024"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="549"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="257"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="516"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3340704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="617" mass="66518" checksum="882D24CAD842A49C" modified="2024-05-29" version="1">MLNMPNIMSNRNSTPEASNVSSLRPPSSRAIGSNHGLRASADVAALTGAQAAASRIRPSSDFYGQPQSGQVQGNAELDPQDKLAQQWIADIDQYETTLEEMAAATLDQDFKDELSAIEQWFRVLSEAERTAALYALLQQTTQVQIRFFIQVLQQMGKNHPMSGVLSPANFDKDPMSSRLSDAMGKLEVGSARNSLARPSGGANKRHSGLDQTTINTMFPDAVAAIATEKAKFTQQTGNPPPSNRNSLVDNRNSLAAPTVSVPKDDTNGQNPASPWGPSDASRPKSSTGQTPMGQFVQPPPSAGGLRSPRPPQLSSNTNIQSTTLTAAEPQLTELPLLSPYTSSGNWASMVNTPMVPTFGQTQGNNADMVANATAMKLAALSTVNNRFALDDARRYRRARSNDGAPGQHPLSPGPQGIPSTNVVMINEHGQVLSHDHVLALQQQQQQGLQQGLGGFGGHRSRPTSPGIAVPNYGPALQFTSPQNNGFLSAYDGGAPGLINNGLVPMMGQFNLGGHHTEGYLSDHSEINRGRSPRGRRGSSKPPEDPTDPTLLQDIPSWLRSLRLHKYTDNLKDMKWTDLIELDDKQLEERGVNALGARRKMLKVFEQVKGESCDSVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC08</accession>
    <name>A0AAE0JC08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_412423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680187.1">
        <property type="nucleotide sequence ID" value="XM_062823846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC08"/>
    <dbReference type="GeneID" id="87861000"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="56" mass="6670" checksum="7FA5E743101499DD" modified="2024-05-29" version="1" fragment="single">RQPSRRDIKVDMGGQQLGRLERTFQASLTNNRLKEWSTRKTTLKQRLEARKAQTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCH4</accession>
    <name>A0AAE0JCH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_427986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680459.1">
        <property type="nucleotide sequence ID" value="XM_062824721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCH4"/>
    <dbReference type="GeneID" id="87861875"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="92" mass="10351" checksum="588336E1B5C23119" modified="2024-05-29" version="1" fragment="single">LSKSNRVVHYPVGNNHLHLAFCRNGSQDPRRPRSLHGPSLLPVQDHARHQQLLLPLRPPPVLLLRLNSITSTLFEHIHWADPSEGHTSIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDT7</accession>
    <name>A0AAE0JDT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_429519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680756.1">
        <property type="nucleotide sequence ID" value="XM_062824830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861984"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22447">
        <property type="entry name" value="KH-I_ScSCP160_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22448">
        <property type="entry name" value="KH-I_ScSCP160_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22449">
        <property type="entry name" value="KH-I_ScSCP160_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="208"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="290"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="385"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="704"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="771"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="865"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="940"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="1090"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="1205"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3342963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1285" mass="140466" checksum="C6C19921DC4BDCCC" modified="2024-05-29" version="1">MADSTEQSAAAQLLQQHLETASDAGSSHRVLVEEVEDEDLHKPVSSSDTPAAPKPAPKPKTLDTQSRELFPELGGPKPKASVVAPIWGAKSNANGSTNGAAPANGTPQTSAPPSGVSTPIGSGRQGPGPHPLSIPGRNVETMLLDPPHILPRTQLKRPLPDILKDLNRKARANVTMHALGNGQLRFDAVGPQEHATQALKDLVNQIGTKQNITVQIPSSARAHIIGKGGSTIKAIQEKTGARIQLPKADESQPPADEDDDTMINVHIEGNAFSAAAAQQEIDKIAGERAANVQTKLRNIPAEFYPFIAGPKNNLVHKLEEDMGVQIRVPPFQGQSLQPPSVPAPGQRPIFAPAPQDYNIQLAGERTAVQNARAAIERRAEELRRQLALEQLSIQRGRHQFIIGDRGVPVDQFFEDTGCAIILPNDEDDDMVTIIGPQDQVQAGLERAMDLAMNMQCSNIDISRFHRQAPGGAAAHARNVTRYLRQRKAIEQLERQHNVQVNTPFSSEGALPWELYARDGKNAIRAQSEIKGLVDSHPPARIQAVQVDPFFHTYIRKDITPRVRHDYRVQLVVPETTEANAPVLLVYEGPSNPTSYEIPRGQPSQSEVSEMQKWLQDARQHIIGLVNQQEEIIQASLDVPQKYHDKLRKFIRKEQDERRSQEKIPARVSNIGTTVNIKGPRSAVENLASKCEAFIEQEKADEKERGFTLEFEFPQKFANHLIGKGGSNIRELREKFDVDIQVQDGKVELKGPKAKAEAAKTHILALGRQLQDEATHILKIDPQFHRALIGAQGAQINRLQTRYKVLIFFPRTQKASNDDESVAEASDAGKPRRQQAADEVMVRGPKRGADEARDELLSLLQYLKDTSYTATVTVQQKQIPSLIGSGGAALDALRNETKAVIDIPSARDTADGLVEIQIKGTKEAVAAAKKALEAKKAVFEDTVVKTVEVDRKYHRSLIGAGGSTIRDIVVKAGGSDDRREIARAVQFPKQDNSDNTIKIEGRTSVVDNIIQQIEAIVAERQNQVTEVIEVPVEKHRSLIGRGGDVKRGLESQFKVSIDVPRQGSGQTGIKIVGQSADVEKAKAHIQSLTKDQPGETLQVPRALHHSVSNNGQIFRRLKSDHHVTVDHAGHSIPAKPAAPASIRANGGALPLITDDEESTADAHSWTVVDQTSTEEGDIPWVIRGSPENIEKAKKVIETAIEQAKKEDAIGYLILPDPRTYRYVIGQGGTKVNQIRKQSGSKITVPRDQAKGEAIEVVGTKEGVEKAKDLILAAVKEGQNASRSPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE53</accession>
    <name>A0AAE0JE53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynein associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_523894</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681312.1">
        <property type="nucleotide sequence ID" value="XM_062828806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87865960"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="76"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="325"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1049"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1167"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3344699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1364" mass="151883" checksum="5AA6B32C988C9ADD" modified="2024-05-29" version="1">MSELGVAVGQKIELADGSGRTAFVRYVGETAFAPGTWVGIELDEPSGKNDGSVQGERYFNCEMGYGMFVRPTTFNVIAQPPPPSKPASSTFKRSVNTRPTSLSASTTRRPAPADTGLAKRMSLNAPSPSPGPRPNRTSSTSVSRSPTRSPTKQLATASSSGAPSRSGTPSTTTKPAGATTRTRPSLSTSRPSMGPPPNPGSRTTRKVSVSSVGTRPSIGATRTVGGRASISARSSTNRLPDPRESTGSVSSIGKSGVKRGSASPRSSDEDLSTSPMPTSPVHQKTAALEKLTAPGAGNGGGTSPGATSPNLKASTITPRSSITNTATMNKEIEDLKAKLKVLEKKRMEDREKLNSLEKVKAERDKFERIIQTLQIKYQPQQQEIQDLKRQLKEAETRLYNVEEMQAEHDTAMELATLDREMAEETAEVLKVELDALKQKNEELELEVEVLREENSEFTTGMSPEERASTGWLQMERNNERLREALIRLRDITQQQEEELRDQIKSMEEDLREFETIKEQHTTAKEKLAQTEAIVEDLREQLNNALGAEEIIESLTEQTMNQSEEIKELRAVIDDLESLKEINDELEINHVQNEKEMQEEIDLKDAVIAEQFRQANLQRESLEDMEYTLSRFRELVTSLQSDLEDMRASHAVTENESEQLNSRSRAMLDLNMKLQISASKAQVKTIDLELRRMEAQEAEQHLEIVKLFLPDTYQSDRDSVLALLRFKRLAFKANLLNGFIKERVNGQPHPGHEDDIFDGCDAIDKLTWVSAMCDRFVNAISHCSLEQFARYEGALYELEPVERALNGWIDGLRRDDLKEKQCADELKRTIALMTHLSEVHISNDLESFADDVHMRALLMQSHLESAANSFNSLKGMVQRVIPPTGEDDELAQYFSKRAEAVVSQTRSAKVIAGKTVRALEDLKTRSLSLTPDTLEAFEQSEAATRDLANMARQIGLDLHAFLHEEGRTEPYNYMEVQSCIQRSAQASSPTASSPESDLFNTYLSHLRNTTSNISDLASLASDLAQTLEFDRTPAPWILRSAELKAAKTVAPDIDDELRRLRDDIAEARRSIAVREEMLSTAQVKIETLESRMRDANAKAARIVDLEADLQAAKKEAQQLQEDMEKQDRELKALESDRDKWKKIASESRVVVADGSGVGVDNKASAERAVATAREMDALKKEIEALQAAVRYLREDSRRARLKEQGDYEWLAEPLVKKKPPVQEQRKQLVKKEGKAVLGELVKLVSSAKVFDLGSLPEKAEDRLKWRPAKTTPGWWVAKQMEDWEALKEWEGSVKGRVRELGGAPGSKKAEREEEAKRMVRRTAAAKLQIRLPGMEGKVGHGGGRRVQIVGSREWESLQGRLAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEE3</accession>
    <name>A0AAE0JEE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_444048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681118.1">
        <property type="nucleotide sequence ID" value="XM_062825664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEE3"/>
    <dbReference type="GeneID" id="87862818"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="128" mass="14684" checksum="D6F50B94957BF161" modified="2024-05-29" version="1">MSQTTSPTTTPPTFHPLPRLPYELRLLIWEATISPRRVEVDFLVLNQLFHQPQWTHRLVSLTPPPAILSTCRESREVGLKVYKKVFLGLRRPIPYVWLNPRLDELKLEQGAVAYAPSVNAFINAALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF36</accession>
    <name>A0AAE0JF36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RAD57 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_508950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681810.1">
        <property type="nucleotide sequence ID" value="XM_062828274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF36"/>
    <dbReference type="GeneID" id="87865428"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="114"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3345197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="474" mass="51203" checksum="8B5FA693B22D963C" modified="2024-05-29" version="1">MTDLLRVLPHFPVGQYANLISALEKVGLTTSDLLTLEAADIGKRTQLPLLDIKRLCAAVLAALHDDLGVFATSRRHQHSNQGQGQQHGQTSTVPAAPPPALQTLKNTPASLAAQWQTISTLDPDLDRALGGGGIPAGYVTEITGESGAGKTQFLLTLLLSVQLPPPHGLGRPALYISTEAPLSTRRLAQMLTTNTFFKGIEADGRERPSLDNIISTVTPDLESQDHILTYQVPVEIERRNIGLLVLDSVAANYRAEFERSSKEAATSSIPGAGAGAARSSNMGARTAELVRLGMQLRDLAQKYNLAVVVSNQVADRFGSKMPEPITSSIPRSSAAVLPTPSVTPYPHPDENPPQSHHPALHLDNQQRFFTGWGDDPYASFPLKTPSLGLVWSTQISARIALFKRPAYGRSKYQADDEDQNGNEKGMPMLKSWRRWMKVVFAGWTAESGTGLDGGGSVEFEVWMGGLRGKFYGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFA2</accession>
    <name>A0AAE0JFA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_574149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681899.1">
        <property type="nucleotide sequence ID" value="XM_062830571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFA2"/>
    <dbReference type="GeneID" id="87867725"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF5">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="251" mass="27564" checksum="C961D885D46D861A" modified="2024-05-29" version="1">MGFNILLPIRVFQATFSIVIIGLSGFVAHWYNTNTAYLPPSQISFLLFCGVYSLLSALYLGLISKLFPKTSNPYAVLSLEITNLLFWFAGFISLSVFLSKLLFCRGSVCGAARADVGIAACLSISWIVTVALLARDAIRSGGFEGFRNHAQTERKWKSSSVSFHGVDGGDVRQAPYAAADGHDEEEGGWVFPGVAGLKTLVVVARLREHKKKESKKQTRRHRATPSMEIVKKKVVGAWDRRGAKETLIIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFH5</accession>
    <name>A0AAE0JFH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_442774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682004.1">
        <property type="nucleotide sequence ID" value="XM_062825595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFH5"/>
    <dbReference type="GeneID" id="87862749"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="205" mass="22529" checksum="75DEEB6ED128DDE6" modified="2024-05-29" version="1">MSFSQRPPAGDLALDIPPTARHPSTLPNPHQPTQNGARGGATSDHRQWSTEALPCKDYRRKNNLNNSPATQRRLNKLRTLPLSLDHRGDHGHLLSALNKHNKHTNKGFGLQDRSGTTSAYDDLYNINNHDRGALGSGSFASYGRPLRDLSASLELAFSQGKKLSRTPAHDQLLSPEARPCSLEPVHPRIKGQDLTGARANGYPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JFS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_199050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681811.1">
        <property type="nucleotide sequence ID" value="XM_062821753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFS4"/>
    <dbReference type="GeneID" id="87858907"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="48610" checksum="F019EDB4B2A71114" modified="2024-05-29" version="1">MGVSRLYRVALFGASVHALAYPGPQATDRVIIPSDAQTPRPTLPPTLHHELFKRQVSGSASGSGSYGDTILIAPDNTCGYVSGLPGAAFTCVNPANSCVFIPSSGSIPGAAGCCNTKVCGFRVACMDYSEVLVQSKCDDGCMADTYTAKCTGTDYPYCGTIAFPGGITDYFCDTLSGSRVQSAKTTWDGETDGRTFLTWTNTGSSSTLAVPTVESSSTGRASSTASSSSSGTVGLGGSSTDPADPDQPEPKKEKGGSNIGAIVGGAVGGLAVIGLVILGIVWMVRRNKRHNNNTPDTPATSAAAAAPGGGHPGLANSPPPPAPSPGNLDPALNNNSHNSYYYAGGGGQPDPNKVPVMTQHYPAPASPPPPADYHNNNQQWNNNNNNPNGSPTSGYMPPSSPASTLMSGGGYQPSSVSNPSAHPHHMSGQSFTGVPVGGGQGPMYGPGGQPVYEAASNAVGGPQELNANHRGQMHELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFT1</accession>
    <name>A0AAE0JFT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_464780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681487.1">
        <property type="nucleotide sequence ID" value="XM_062826774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFT1"/>
    <dbReference type="GeneID" id="87863928"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000046">
        <property type="entry name" value="TBC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="803"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1140" mass="123980" checksum="5BA3E5794B588370" modified="2024-05-29" version="1">MEDTTPTTTTPAAAIASAAAVAPLERSVSQQSVLSTTRSHRSRTSSTARARKRLTSYPSSSASSIAPSDKSLTSFPSFSPESPRLELSFFELNPSSLSPSISPSRNSRKSSDPVSVADSVSNDSDPHQTPEAPQPQRIRPASMVESLITAEPEPDTRDALFQDVPLTANKIPGSLHHADNAHIERLIARHGATNLVRQISQDLAERDAQIATLRRRADDRERALRKIILECGLSTLDLETRLRAIEQDAKQTSLARKGTADGGLSDLMNEAMAHDLRAVGASTGLNDATIRAATMSVPPATTKGTNKGWKDFLWGTGTTGKNSGRPSSVTSAGTGTGASATDTSKTVIRGSGLGPEQRRPTLADDLFNPPETDSTDSVPGSSRASSINSANESRKSSLASLALRLVAGGATTGRNGDMRGRANTARQPGGSMRTPSTSSRAASSVSNRTVSAAQTGPRSLMAMRRRTTGPAKPIDVPQRYQQQDRWDTMGSSPSRDLVSRQQSYGPVEMDTILPPEVQPPTLTHIYNNHFGSEFLTDRFGFIYDQRRKKRQREAARMARHAKKPSRTEMLSTGRNRLSPVMLDESSSGRGDTANEAGPESPSAEEQRDDSKPRKWQDYLKIATFPTELLSHTPLITVPGFELMEGGEVPEAPKSPGLITSEERGFVPSATPAITAIALPENEDQPSPDEGEQQSSSANMAKEDAEPVRLLLQNLNQLHDTLQREKTVRWNDFLRKVRAERKRDGEAAAAAAAAAAEARFQRAEAVMPETRLGDGELIGVASLGIQGKVGRVKANEFRQLILGGIPVAYRSKIWSECCGAKALRIPGYYDDLVNRPEDQDDPQVVAQIKADITRTLTDNIFFRKGPGVEKLNEVLLAYARRNPDVGYCQGMNLVVANLLLITPCAEDAFWILVSIVENILPPNYFDHSLLASRADQQVLRQYVSEVLPKLSAHFEELGITLETMTFQWFLSVFTDCLSAEALFRVWDVLLCTHDGGVFLFQVALALLKLNERQLLACDSAAHIYSYINHQMTNHAISIDGLIQASEALRRVVQRDEVEARRTKAVELEREMSRAREKRREEMEQQMKKLAEVQAQKTAGAPAVTDQTVASVNVSSDDLDTPTVGADDGITGTIQSAGGITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFX2</accession>
    <name>A0AAE0JFX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_200434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681851.1">
        <property type="nucleotide sequence ID" value="XM_062821775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFX2"/>
    <dbReference type="GeneID" id="87858929"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="91" mass="10143" checksum="8A328AB3FBAAB131" modified="2024-05-29" version="1">MFGYSYIRYLHIPLVLTRSAFLQTCGACQCCELGRSVIRVEEPARRKPQNFGNPGTSSCDLIVSFQSDRVPTLSQCFPPTARRGSADRPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG24</accession>
    <name>A0AAE0JG24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Feruloyl esterase C</fullName>
            <ecNumber evidence="11">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ferulic acid esterase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_212156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the faeC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682320.1">
        <property type="nucleotide sequence ID" value="XM_062821946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG24"/>
    <dbReference type="GeneID" id="87859100"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041781138" description="Feruloyl esterase C" evidence="11">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3345707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="302" mass="31391" checksum="D65C7671CDAB5FA4" modified="2024-05-29" version="1">MYLVGSLLLGLAYLTGALSTMIPGPHTRATGRSPGCGSAPTITSGVKSLTVNGKQRQFTIRVPRNYQKDNGYKVIIGLHWVGGTMDQVAGGGTTGEPWAYYGMQKMANESAILVAPQGLNNGWANSGGEDILFIDAINKYIDSGLCVNQAQRFSMGFSYGAAMTYAIACARAKDFRAVTVIAGGQLSGCSGGNVPVAYFGIHGVSDGTLNIAGGRTMRDRFVKNNGCASMAGAPEPRAGSRTHMTTAATGCKPGYPVLWAAHDGGHGPAPADAPAPSSDDGLRTWMPAAVWAFYTQAQLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ31</accession>
    <name>A0AAE0JJ31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_175317</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683506.1">
        <property type="nucleotide sequence ID" value="XM_062821432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ31"/>
    <dbReference type="GeneID" id="87858586"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041960690" description="CFEM domain-containing protein" evidence="18">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="19">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="104"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3348424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="312" mass="31135" checksum="02CD1B68E8A26ABD" modified="2024-05-29" version="1">MLILKTLALLAAAVLVTGQSVDSLPTCAQNCYYSSRDGFAQCTGADQASMACLCPNADFFNAVHDCASKACQAEFGAQADEYAGTAVAAAHAVCATATVPAAAPPATSAAPANSDAAAPPASTTAPETSAAASSVPSAVSSSTEPTSVPTDAAATSATAPSTAATSTTESSESATSTGAGAIVPVPTGGSSTSSASAPASTSKDKDEDDDAAGGLSKGAKAGIGAGIGVGSLVLLITLALVLFRKRSTPKDHIKISDPVAGGRHYASDPYSHNNFSRDTSHGGITIMSENELEMKSRRYEDMLPRQQPRNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJR5</accession>
    <name>A0AAE0JJR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_421207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683983.1">
        <property type="nucleotide sequence ID" value="XM_062824326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJR5"/>
    <dbReference type="GeneID" id="87861480"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="129" mass="14470" checksum="F33F719F7B670D96" modified="2024-05-29" version="1">MPSVKNPNGPSRNRLIARAASLRKQRQRQSAQGKLEKIHKITKDDLARGARPGLLPNSGPRKALGKKAQRKLEKKLGYGIRRKMEREGLSKMEVEKVEEMMGIGKTSKKSAETKTEETPATKEVEMDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK32</accession>
    <name>A0AAE0JK32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Mevalonate kinase</fullName>
            <shortName evidence="19">MK</shortName>
            <ecNumber evidence="3 19">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0H65DRAFT_99636</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18 19">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 19"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684116.1">
        <property type="nucleotide sequence ID" value="XM_062831675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK32"/>
    <dbReference type="GeneID" id="87868829"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000027">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="23" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="12 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="21">
        <location>
            <begin position="206"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="22">
        <location>
            <begin position="378"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3350821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="528" mass="57962" checksum="E39634C069EE76F0" modified="2024-05-29" version="1">MAEQETNRVSGFHSESDQGGQHINGDASEAVNENTSNGLRVTIQEGASSSVNGGSPTNGTITPIRKKMERKKSSPMMPTFMVSAPGKVIVFGEHAVVHGKAAIAAAISLRSYLLVNTLSKSKRTVTLKFPDIDFNHSWNIDELPWKIFQQPGKKKYYYSLVTEIDQELFDAVQPFLTDVSIDKPADIRKVHQNSAGSFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPHPDQPPEEARLQIERINRWAFVYEMFIHGNPSGVDNTVSTQGKAVVFQRTDYNQPPAVRPLWDFPKLPLLLVDTRQAKSTAHEVAKVATLKKKHPQLVGTILTAIDQVTQSSAQLIEEQGFNTEDEESLSKVGEMMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCSITLLRPGVPREKLDKLEKQLDEEGYSKFETTLGSDGVGVLWPAVLKNGMDEDDVGGMEIDVEKFLSADSNEALEKLVGVHGDRGEREGWKFWRVENRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK69</accession>
    <name>A0AAE0JK69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H65DRAFT_439755</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684061.1">
        <property type="nucleotide sequence ID" value="XM_062825440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK69"/>
    <dbReference type="GeneID" id="87862594"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="524"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="464"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="895"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3350766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1138" mass="124857" checksum="7F0AAFD7017CDAA6" modified="2024-05-29" version="1">MRAEIAVPAIAALCYRAHSKKSLTPGGIFAAFLTAVAHAVHPWNLPFALLVVFFLAGTRVTHVKENVKAKLTVHSKGTSGGEGPRNHIQVFANSLTASIFSLLHAYQLHVRKQALIANPTSTGTGSLCFSWGGDLLVIGIIANYACVAADTFSSELGILSKGEPRLITSWNLRKVPRGTNGGVSLVGLGAGLLGSMIIVTASMLLLPLCTDETAMRLGGAAGWSLGQRRMLILGLTVWGFLGSVVDSILGGLFQASVKDVRTGKIVEGEGGVRVLVSNATNPNSVAGRTKAEIKASLLSGEGADAVEDVGAAGKASGKGAASGNKYDPRNKQRRSSFGDERPSRVVENGWDLLDNNDVNFLMAFGMSVGAMAVASWYWGVPLQSVLPPWWAWLGGPEALATAPSPVVGRSPKRSDPAVPPPSDDISSDKRTTFHPRSSAVALQAPPPAMAQAYDDEELSISLSPSQIRSRNKRSGDGASGFGPSTGNLHEYGQHGQQLHPNINAVMADAPLRDKMRTEQRIGAYNIVKTLGEGSFGKVKLAVHRSTGQQVALKIIARKKLISRDMQGRVEREIEYLQLLRHPHIIKLYTVIKTPTEIIMVLEFAGGELFDYIVQHGKMKEDEARRFFQQMLCAVEYCHRHKIVHRDLKPENLLLDENLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIGGKLYAGPEVDVWSCGVILYVLLVGRLPFDDEHIPSLFAKIARGSYMVPTWMSPGAASLIKKMLVVNPVQRATIDEIRQDPWFLKDLPAYLHPPVEEFLNTGVDPNKAIKVSDIAPNAPPQEQEKLHNEVTEKISKTMGYGKRDVEEALEADEPSAIKDAYMIVRENKLMQSNRTSPRPYVSKIGILPSSLPTYHRVFMEREKAKAEGLEPPDAIPTIVEPANQPRSQAEQEETIRRLKPHSRSQLRLDEANKRPQGLTPVNPPKKNKPARWQFGIRSRNAPWEALVCIYKALNKLGAGWIVDEDYERAHRDDDDTDDYDGPTIGRRKSTSNMDPTKIYRLPADPWHIKIRWTTDKLKKHSIASGLSEAGENMHVTRDGGDSKYQVVAMRMEIQIYEMEHGVYLVDFKVDGYETPDGKLLEDKEVTSPFPFLDMAAKLIMQLADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK87</accession>
    <name>A0AAE0JK87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_101834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684173.1">
        <property type="nucleotide sequence ID" value="XM_062820447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK87"/>
    <dbReference type="GeneID" id="87857601"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3350878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="156" mass="17139" checksum="0420261B90087B37" modified="2024-05-29" version="1">MSSHCTIAVPRAHCSAITVPTVLQGTIRALRAAGLRIQYVGGYGHLHDIATTTTTAIATLSPYICDKDKTERSRLFLLLGHWTLSLADPSRQHAVLGLAMGEMLRTRDSPGYSTVSQSKTSIIEFVHVLEWIDVMAAISLRSDGFRSRQCLHPKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKD2</accession>
    <name>A0AAE0JKD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4048 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_419353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684539.1">
        <property type="nucleotide sequence ID" value="XM_062824202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKD2"/>
    <dbReference type="GeneID" id="87861356"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025122">
        <property type="entry name" value="DUF4048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13257">
        <property type="entry name" value="DUF4048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4048" evidence="3">
        <location>
            <begin position="410"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="674" mass="73503" checksum="BF8AE53058972264" modified="2024-05-29" version="1">MTSSSSTAALRSALPVLTTCSISACANALLLRDSHPLNIHTAAIVARRTTRFPTTTIPNTALQQALQQLCDRHRTTRTRRPCASTVTPYHPPNINTTTATTTTHSFITTATIHQQARYLGPILSQFRREENSLVMAHIVSPQSSFGQVAMQSAPLPRRTSSLRSRARRGKSTDETEPQHVPDEAIATALAHSDDLTENRSTRSASTASRTTHRLSLTLPIAPPNPNPSRPIPTSTTTASFPPTPLDTPALTSPADSNDFITAIAAQERRVLELREELSRAESDLAKLKKQWATHEAYKKRGERPLRSVGLVPTFQDDEATKRVVELDRRKALLQSLQNQNQPLPENGRRRVFQGGHARTLSLLSPTKPSSDFPGRGDGSENSRNVAFSPSHRPKHQSWAPQTASQTVGVKGIAQDLRMGLWTFMEDLRQATVGDEPITGQGMYMRGADGKLIMTPMPNGGTASSPSRTGGQDGFKASGLNTPRNRSSTAFDWAPAAATSRSTSPQKEAQDSTADEALKSPSRPAPALMRSKTDSTKSSKRFSWTPLTMDSVDDNDWSNWETAGVATSTRWSGTTVNGDIIPSTTSEKRTENDTSLSSKQRVAAASSRSPAPVITSTNTMLEDLFPPVLTKFTPSNLKKTADYYMKEWEKSLAPPEMHKQPQPAYHTIGTKNMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKI2</accession>
    <name>A0AAE0JKI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_567341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683947.1">
        <property type="nucleotide sequence ID" value="XM_062830364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKI2"/>
    <dbReference type="GeneID" id="87867518"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000399">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3350652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="548" mass="60817" checksum="DFD3519514EC7E90" modified="2024-05-29" version="1">MAQKPSDTPLGENVTHVVPYPMAKLPSDGEGELENGQVPIQPDQIQYDIDRVERIYRKLDLRIIPAFWILYFLCSAIRSNIGIAQTMNRDVHHDLMSVLGMTAKDTSTALALFYVSYVIFDLPSNLVMSRLSPRAWMARIVFAVGLIGTCFTAVKAPWSVKFLRFLLGFVTAGMWPGMSFYLTLFYPPSRTGKRIGYYFTASQLSAAVVGLVSAGFQKMDGLHGFTGFQWMFLVYGVLGIALGIALLFWLPDRPLAPGEQRVRHKWLRWLPTSPEALTGEDALIHYQDLKRVYHSRPWNMKDLWYVLIDWRLWPLVLMYFGVVGVGIGTQLYGSVIIASINPNFSDITVSLLFAPIWLCDLVAILLSTGLADRFHKYRAVFFSTGALIQIAGLLTTTFALGNDWARYGGLLMIGFGLGPTVPVCMAWTNEIFQKRHREVGVAAASALVSGLGNLGSITTTYALYTGWPEDAAKGPHQYRKSNYTMIGILAMSIASSIVLTVLLSIFGMEPSQRVVASSGSSAEEIQDGAALRERQMRGFSGMLGRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKT2</accession>
    <name>A0AAE0JKT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_439997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684346.1">
        <property type="nucleotide sequence ID" value="XM_062825455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKT2"/>
    <dbReference type="GeneID" id="87862609"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="710"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="718"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="901" mass="94134" checksum="F78ABFB5279754CE" modified="2024-05-29" version="1">MVTVQGMSFAVSDLPLGENKGGDNAFCWQDAATDDAGSADFFDQFVVLDDHGADHSPSPPFTGEEGGAEGGGNESFESMCREAHESSLSPPLTSLSCPPLDHHPSAEQLSGVGDHDRASVAANNSASGRLGRFSSAKFPPQHRQVRAGSHVDLSNMDCQYSQQHHQLLVAGQREISSILGTGYQEGPGSGGSISDSELLRLEGLTVNGSGSPRIHLPPSSASVPPSPHLQPGSDSTSPRKSRLEAFYTKIRNKAANLHGNKQKQHPATTAAPAVTSSIPSAMGTSPNKMTARPRPHNLSLVRPEMPLSPPLTGQMAAEPNSHNDGNNAHLFNTNFMDDPFMDISSNMSLPMHTPIQTPHQQHQSIPVPVTTAADNSWQFSVSGPPPTTPANPSTLHAVGGVLSSASELHSLYAGTLNDSNWWDQAVGDAMDTDPDPSSSFHMGTNASNTREATLNLQMALQQLHDQGSFDDHHFGLDTSGLVMHMPQPTSRVSLHHNQQQQQQQQHLNQSQAQSQAQAQAQAHAAAQLLLAQQQYVSNSDGLPPHSSSSTANSTSTTTTRSRRPKPRAPSSGASRLPSYQTSPRKVRAVSRSSRESSPTRGSQQPNSGSLAVPGTDSMSASGSGRQRLHRCSASMQNINHQSSNTTPGLGGLGLMSPAAVRKRKSFTGRGHASSVSVSAGSRLSHAASHGDLGASASAFAAAIGASGHRVVPEGSGTGSSRGLTSSASTSSLPTNSSAGRFTPLNMNNMNGGGFHHPHHVNPGVMAGYPPMPPLPPHHLQQGPGPGASSSLPPPQHQHQHQHHGLGLPTHHHPSFQHKSIPMHPSSSRYSPSKSKPPRSSSSVSKPQHLAQSSSSGGGGSGGGGGGGGIDFVNFTPLDHHTLMSGGKRGGGAEEEVIRGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLL2</accession>
    <name>A0AAE0JLL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_419093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684973.1">
        <property type="nucleotide sequence ID" value="XM_062824182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861336"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140278">
        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11889">
        <property type="entry name" value="SH3_Cyk3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035553">
        <property type="entry name" value="Cyk3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="627"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="699"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1260"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="700"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1316" mass="143319" checksum="C3908DB5268BCA88" modified="2024-05-29" version="1">MVPAPPPVPTRFPCWVRAVYSWGGENKRDLGFIEGDLIECLNAGDGSWWTGRLWRDRRAIGVFPSNFVELMPENFRPTSRSASPMAASHSPSPSGTPHKSRTFRKPFEAYSKAPHYTTAKVPETYKDCSVSRPPRAGSIRQRSRGPIGHPGGNDYGYSHGGTHPPSHGGRAPSPAPFRAAAASPNPYRAPSPAPYPVPIPPPLAGSPAPTGPFRAASPSPYREASPAPYRPRASSPAPYVPSPAPYHSHSHSPSPAPLRNASPSRSRSPLKHQLDYRGTPPIRDVSPARVYSPMRAHSPAPPSPSPSYRPYRPPQLQDGQYQEGGPGRGDTPPPPPPPHRNLVSRHGSKNSYNGDQQSPYYEDIPRPNSTAPYNQNSNGYPMARTPSPCPPSPAASGAMTPSPLREAMDDVMEQLDVLSGGGKLPRDGSPEPFDPWAPEAFEEIHQKSRKARDKRPQSTMLIDEGYETYSGTGSSLVGPASKPPQQQDEPSRLPQLSNYVERMESRLRTMHQHSASMNNITEQGPPPPPKSPFMNRPKSSIESRVAADPRLRKKKSSYDMGRQTLDRSSTTKTTSTNASDTPSNVTFSSATTDSTNRSLMSGVSAGGISATSAGSLARKNRIRAHSALSIQEESDRPGTPFTGVTYHSSHASENLHMRPKSRTDLGQEDSMGNLGGLVTPKPKKQNFIKRILESAKTGVANSRNSIASAGSSSPTKSATNPLSALSGGPSLLPAKNIGREGMGSGVDWVQVRRDVNRSNSLSQNERTERKERCQMLDHPALNPVEELYNSIDGDEGDDGMPVQEPFNYLAINLSQVDKNSRFVASLPPTITAASLAATYVCRPYNSDVQRLRAIFTWVSEKVCWEEDFEGPIDTRRVIHSKRGCCEEFAVLVAEMCEAVGLHCEVVRGYLKSPGEIPDANIVPRPNHWWNAVVVDNEWRMMDTCLASPSFPRRALYSSWNSSQADPWWFLARPTEICWTHIPEHHEQQHICPPVAHEILLNLPCACPPYFKNGLDMFDYNTSLTRIEDLEMVHIKFNVPADVEIAAEVETRAFTKDNDGDVFESGEVVKKRALAQAEWFGGVKRYTVKALLPGDEGTGTLKIYAGKRGLMHSIKDIPHPLAFALPIIHTGENPPYEFVTRHPTPHAQRHDLYIVQPQCQGLALNNTFVFIIRQHPSSSSTSDGPTSPSITSGSASPIPFLRPSSAMSMTSSAAGGSQPSTTAGGSSGSSSKKPAKLAIQTPGGKILRLMRKEDRGGKGGIGFGSRAAAQAAAEPGEEGDGGTWETIIKCSERGTWRGLVLADRTARWCVFAEWVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLL9</accession>
    <name>A0AAE0JLL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_546307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684547.1">
        <property type="nucleotide sequence ID" value="XM_062829440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLL9"/>
    <dbReference type="GeneID" id="87866594"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38223" checksum="BC94234214A3E61B" modified="2024-05-29" version="1">MDAKTLYPDFDDLPKVEGQPQGCAWGLFDKDGVKDIYGTLNFITPETVKAAAAEVQHGISVSLNWSLNAIKFPFGHRQAPVHTPFALPAEMGTKGLHGFDDSLTFNTQYSSQWDSLCHVTHSHSGETYNGFVPTVEKLSSTTSTKKENEKEGLLPTIDRWHTRGGLVARGVLIDWKRYAEEVINSKGETGPKWHPLDGYKITFDDLEAAAKHFGVEFKVGDVLLVRTGMTSVMENPTPEDFGKMADSKLAGVEGSERTARWVWNKRFAAVAGDSAAFEAIEYSKETGCDLVLHRYFLTMFGMSIGELWDLDALGEACKKTGKYSFLLTSAPLNHPGLVASPPNATAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLS4</accession>
    <name>A0AAE0JLS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_133011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685046.1">
        <property type="nucleotide sequence ID" value="XM_062820835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLS4"/>
    <dbReference type="GeneID" id="87857989"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="251"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3351751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="353" mass="39195" checksum="9B8DD733CD7676DD" modified="2024-05-29" version="1">MASLRGVSRSARALQPFSTQFVARRCASTQATGAGAAAAAPKSNIPDLAELETRSALETPLPSEEDKKDFRPWKRAADRKARLPSSRYQYHPPKYNRGPLHPIQSPASSDPIARDFVPGPFNMPRLKETFRTVMASDLMTLTYIHTPPGTPKKEPTERLRAWEGDSPYFANRARRAPRGAPELPIRERDISFRNIPEIQEITVSTFVPLGLKNPDMLIVARAVLLAMTGTMPEMTRSKSNVVQWQLQANKPAGCKTTIYGNAAWEFMDRLVHLVFPRIKDWKGVAASTGDGSGNVQFGLNPEDVQLFPEVECNYDMYPAKMIPGCHIAIKTTATSDRQAKLLLQSLGVPFYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLW4</accession>
    <name>A0AAE0JLW4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_136126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685123.1">
        <property type="nucleotide sequence ID" value="XM_062820872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLW4"/>
    <dbReference type="GeneID" id="87858026"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="301" mass="33426" checksum="6656113FD34CB1F0" modified="2024-05-29" version="1">MASPASVSKVSSSIVVARGSTNETDWTVNYGLSYLEPNPETAPGHAIDSKRGYKDVSTNSASVSVSTRRSPSYHGTDPHRRRNSGRTGDILSFALRPSARVAKFKLEQQRLEKTSRFRNCRHALQPHAVRKTKTTSLQADSSLAKFTDFSESFSPCSWRAGRLSRFASFRPVKKRGRIRCFCAIRNAPRMKSTRAFTMAKSWCPSQHVCLGRAGVDLEKLGKGNASSVIDHSFIAIPLAEKKDCAKKKICWSVGRKMGTFDSVRFLSEKLSRTSNGMNRINGRRRETHPMTMGDVATSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLY0</accession>
    <name>A0AAE0JLY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_547059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685374.1">
        <property type="nucleotide sequence ID" value="XM_062829485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLY0"/>
    <dbReference type="GeneID" id="87866639"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
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        </location>
    </feature>
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            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
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            <end position="484"/>
        </location>
    </feature>
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        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="602" mass="65343" checksum="D9C6937E972205E9" modified="2024-05-29" version="1">MAHMQYNQQAMPSGLASRRGGQNIKPLSFDFKSIPENDTGIPTPRTSRSHLLAGLRTAPKSATATSFSVGNGPASPTVNPHARNSRNNSITPGMYDGASYLNGPKTSMPTYGGMHQAQQQAMQQQALYNAEVAAYQQQQQYTTDQIMVPQLSMDDSVQGELDPNVHAQLMYTNHVLAQRQQQLQQQLQALQAAAQQLQSQGYRMQGQAPASQHNHQSAVYQQQMQQQVQQQVEQLQQQRLQQQYLALQQARAQQAAQIQHLQQLQALMTPTATQQQSAYSLYDPTTGQQTLYEATNQLANQTAQLNLNSYGGVQQPAVGTPRLQVSPPPPAEASKSNSRSSSPPRRFESPVETAVNPLPPPSANAFRRGYKKTISTANGNKNQLSISTNEEPPKTAGPKTSTFPMTPMTAGYGPGQARAGEHPVRQPRNPPSLDELKSKPTSKHEGSKNFVARTRRSAIHNLVRAGLERRKEARSSGSISPISESADELVETPLTDNDSDSGRSGSGILLDHDDAECSLPSSRTSTGSWGAIGSDRPSSRQKTNRTSVDSTNCSDNETASRDSGSFASLLKNSNRGAKTEAVDGQQRKARLVLTAQKRSIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM55</accession>
    <name>A0AAE0JM55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0H65DRAFT_504275</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685514.1">
        <property type="nucleotide sequence ID" value="XM_062827897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM55"/>
    <dbReference type="GeneID" id="87865051"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="22">
        <location>
            <begin position="543"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3354136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="749" mass="83809" checksum="C514824D315DD34D" modified="2024-05-29" version="1">MSADSLERLASAGKGESTRTLLRVIILLLVAGAAISSRLFSVIRFESIIHEFDPWFNFRATKYLVANGFYKFWDWFDDRTWHPLGRVTGGTLYPGLMVTSGVIYHALRALSIPVDIRNVCVMLAPAFSGLTAYAAYLLTNEMTPSSSAGLLAAIFMGIAPGYISRSVAGSYDNEAIAIFLLVFTFYLWIKALKLGSMLWGALCALFYGYMVASWGGYAFITCLLPLHAFVLICMGRYSTRLYVAYCTWYALGTLASMQIPFVGFLPVKTSEHMPALGIFGFLQLLAFLDYVRSAIPSRQFQTFLWVFAGSIFGIGLIGLVVATSAGFIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPAFFFDLNMLIWLLPAGVYLCYQKLADEHVFVIVYALFGSYFAGVMVRLMLTLTPVVCVAAAIALSTILDIYLKAKSPIPEEHLPEESTDGTSKKASKSGLRASNKPYIGIYATFSKVTVVGAMTAYLLLFVAHCTWVTSNAYSSPSVVLASRMPDGSQHIIDDYREAYQWLRQNTKYDAKVMSWWDYGYQIGGMADRPTLVDNNTWNNTHIATVGKAMASREEVSYPIMRQHEVDYVLVVFGGLLGYSGDDINKFLWMVRIAEGIWPDEVKEREFFTPRGEYRVDAGATETMKNSLMYKMSYYNYNNLFPPGQAQDRVRGVRLPDEGPVLNSIEEAFTSENWIIRIYKVKDLDNLGRDHASAAAFERGQKKKKVIKKKGPRVLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMC9</accession>
    <name>A0AAE0JMC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_143774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685363.1">
        <property type="nucleotide sequence ID" value="XM_062820973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMC9"/>
    <dbReference type="GeneID" id="87858127"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3352068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="156" mass="16708" checksum="8A861FBA29344D83" modified="2024-05-29" version="1">MRAICSLPSSVVGTWAAVGTPAPMGAASPGGMSGSWSAALSEMSSWLGRHLFGGAGGLSSSSVAGRVLFLSLLLAGGRAHVPLGVHYIYASSPSNVKVRKVRWTAKMKKTNKRIKNGSKDWKDKEYILRHGEQLERKSLLERKLRKLGGGRGWDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMU0</accession>
    <name>A0AAE0JMU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_137827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685162.1">
        <property type="nucleotide sequence ID" value="XM_062820897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMU0"/>
    <dbReference type="GeneID" id="87858051"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="228" mass="25836" checksum="485032FC6E85E4C8" modified="2024-05-29" version="1">MGGFRRDAFTENQLAKLSPFIGDFITGDQSFFMATYYMYFPFLTCEVKCGAAALDIADRQNAHSMTLAVRGIVELFRAVKREDKVNRKILAFSVSHDHQSVRIYGHYPVITGKDTKYYRHPIRNFVFTELDGKEKWTAYRFTKNVYDTWMPKHFENIYSAINQLPSELNFDVPPLSEATGLSQDLGNLMQSDVSCASLPDERGSQSSNAGQQAVTPGTSFSEPKRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN35</accession>
    <name>A0AAE0JN35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_19127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685992.1">
        <property type="nucleotide sequence ID" value="XM_062821647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN35"/>
    <dbReference type="GeneID" id="87858801"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042076730" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17300" checksum="24E2A2D3A2DD5EFD" modified="2024-05-29" version="1">MLIGQPIIWVSFHLRWCGLAVAEGASPVAPALVATTREKSLQSHFGSFGPLGERGACLALRAFHLRRVKPAFYSLRLAAVPGIYRLSTSLRLPKPSPSSIPSPRCQVGSRSKMRTIRPSDPSSELCLHLHSLLAPDSARVCFTTHRLSHSSSFTPRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN59</accession>
    <name>A0AAE0JN59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_417751</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685960.1">
        <property type="nucleotide sequence ID" value="XM_062824107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN59"/>
    <dbReference type="GeneID" id="87861261"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="256"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3354582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="549" mass="61758" checksum="F8CAFA07F9253A8B" modified="2024-05-29" version="1">MSIPGDRQHFWKVKQWSWMPGVKRNLIYAPLWNKRHNREIRLSSAMNMGTLPSRLHSVLLLLYLVSNLAYMFALNWGNENKYSFLAELRGRSGTLAMVNMVPLIILAGRNNPLIGLLQVSFDTYNLLHRWMGRVVVLEVLLHMIAWAVVQVADNGWAGVKEKTFNDRFIGSGMAGTATLVAILILSLSPIRHAFYETFLNTHIILAFVSFAATWVHCVTATVPGGLPQLPWIIGIFCVWIAERLARMFRLAYCNWSRARGTTTAFVEPMPGETCRVTLSLPRYVDVQPGTHAYLRFSGVRSWENHPFSIAWVEHTTEDELLPITEKDIGAASSSSSRLSVKKPVATSISFVIGAQSGFTRQLYNRAVAGTADRRRPGITIRAAFEGPYAGHHSLDSYGTAVLFCGATGITHQLSYLRHLVEGYADGTVATRRVVLIWVVRDFESLEWIRPWMDAVLKLPRRKEILHIKLFVTRPKNPREMASASRSVQMFPGRPNIPMLLAKEVHEQEGAMCVTVCGPGGLADDVRHAVRSCQRERGTVIDFVEESFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN99</accession>
    <name>A0AAE0JN99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_13812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685843.1">
        <property type="nucleotide sequence ID" value="XM_062820899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN99"/>
    <dbReference type="GeneID" id="87858053"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="386" mass="41877" checksum="52013A19E07617E1" modified="2024-05-29" version="1">MRPNMPRRTLSGSSHGSCASPSPLSDEQFAFSAGNTPVREIPPSYVASARDALLFGTREVNSKSQTTTFISESKDASKVVTRSKPIAIELPPTRRLSTAPVETPPSPLSARGDIQGGYFPNHEDPATRVHRTHPFFTLDPSKARHKALHRAAETTHLSAPLTDSRVRTMANDRSYSPLSSSVGATRSAGLHTPVSSYMPSGIHDNIALPMGKYYPTNYENRMASNSNQHRRPSARADAAGVAHSEPQLKYLRENSHLRTGSEAKRLVEQYQRDMVAQASMALYSNASSMSPSTRIPDNAALKNIQLGATMLKTHKPLSPRLVPLGSPGPVTPMELDGNGDGYLSRGRAVGGLDAGSQNANIARTIRAEERQRREAQSPGWDMKSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNB7</accession>
    <name>A0AAE0JNB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RhoGEF group protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_449531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686127.1">
        <property type="nucleotide sequence ID" value="XM_062825961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87863115"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="907"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1134"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1369"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1204"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1208"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1732" mass="191498" checksum="D6C752AF427F4AB4" modified="2024-05-29" version="1">MSFRGDDSRRYGHVPPAQYPVAGTAQDNNNNPPYPPQRRLSFNTGDDAAMFDPSAARQQPAIYTGGPVVSRAEEELFITSPTSLDAPAAQNRLSYNPQHIAMAGYQHQYQAQTNAPPPAPTHSTYNPQAFARTQSTSLPYHPAPASRYGAPTSPTYAPTPTTYTPPAYNPAAYANTNSATPQRHSSVASVASSGYNGYTYGYTSPSIPQSGFGQSPHEPARSPQYPPTSPQYDQSYPPANAYNTQQYYGSYSLNGVNNASGMAYHTMTSQAPYPTQHVQMPGGPSYASADHSAFAGRNSRSDSQVSAPSPPAHSQAPGGLTRHPTNAPLPSRPMDDLPEDQSWGPNGQSDEQDALFSDIISEVGPRQYHGVNGSISEDDQGLHRYSSTASTNVGSAAAVDRYPSNASTVNRNDIPNTYPNTYDYDDDESDPEGAAGLLAMQEDMDDRRFGFGGISIPAYMEPPAAQQQPASPSHPIQPPGHQRELPPPPEEQGTDGDFYGMDLGLYGGGYAGTLHYGNEVGSPPATSTHFDQGPRPLPYPQNTGSEYAPFSQAAVDYGGTGGLQAPQTHRLSFDEGDEHVSIHSRQSGSDSPTKEEYPDMFYHPGISNRPLPAVPSLGESRPALSVLPPSRVASQQGYNMDVNQRLMYDQQGQAAVERSISLSSHSNTPPVHTPARSRTDAAEERRRALKHANQHHSHLGHHSVPQDGYDSGTPSSLAAYDMITLPGRKRKFIPSKLTATEIKRCAEPWALSSVTAWIREMADGEVDLKRKSIEEGIVKLFCHKVPTMNVADAEGLSATVVDSMYASGLLIPDEEWVRFGTGQMTGVLWQLTGHGCYAPKLHEAEESAPKLNDNGIPVRCYSHHCGRTLKKANLDHLLSDDTVVQDWATFHGVKPEDCEKKSKKEIERQNVLHEIVTSEEEYMAQLDVVRLLYRDQLRVHQPPVLPNTRRDKFLEAVFGKVDTVQQINKDHLLAQLKYRQQEQAPFIVGFSDLFREWIRKARPIYIEYCSSYPNSEYLIRKESNRNILFREFLGHVQNHRRSKRLGWTTFVKAPITRLQRYSLLLSTVLKNTIEDSEEKQNLIKAIEEIRSVTKECDDRVAEMTKKVSLLELQHQLVLRPGFQSVLNLDHLGRELLKQGELQRQGSKGVRWVDTQALLFDHYFILAKAVSTKDGRNEKKYDVSKEPIPMPLLFLESMHDEPVTKQKGLAAPLTRTAATTGSGTQLNKVASNGGDRPGLEHSATSSSMGSLSTVTRLTSSGVDDGKIIYPFRIKHLGHEIYTLYASSALDRSEWCKAIVDAKTRHAEALHAQNAEPFRLRVLSDGAFAYDSYSTFGRQQGVPISGTPLDRAIREMEEAYGKGRGPPPVCRAQVNCATAFKSFGKSIIAIGTDYGVYISEASNPRGWTRSVQISKVTQIAVLEDFSVCLLIADRSLISYPLDVIAPVSNFPSPVHDNPRRAPQRLAKDVTFFATARMKDRTLLFYKRKEGMHNTFKVLEPVFQKATEKKSRIFGSRKSASGATESFRDYDEFYLPAECYSLNLFQSYIAVASAKGFELLTLDKKVTQSIPRDLNLPAIANIASRIKDQRPLGMFKLNDQEFLLTYEDCAVYVDKHGEISRTLIMEYSGKQKKAKAATMFGQYLLLFNEDYVEVRNAENGRLRQIIAGRDVRCLDYGFRGPTGSGQQHAQPHTLLQAGALQDSRETVKICMSHPEVPGGQIVLEMLLNDGHAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNK0</accession>
    <name>A0AAE0JNK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_13936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685846.1">
        <property type="nucleotide sequence ID" value="XM_062820907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNK0"/>
    <dbReference type="GeneID" id="87858061"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="97785" checksum="F7BC5CD5E7070AB4" modified="2024-05-29" version="1">MAPKPPPTHPPTHAQAQPSSSTSPLDTASVPYAPSTLQEFSSSDQPYNSIVSFQHIAVQQPYRKYSTEELRLADYQAGRRFTVSLGGAGVASPSSLGSSTFGTTDGTVAVSKSKETTGSDSGSNSSGGVSLFGTNNTPVSLFGNNSVVKTGVTGSVKTNNTTSSIVGSNSTGGGSLFGTNKNPVSLFGNNSVVNTGATSTVKANNTTPSIFGSNGSLPLSTGSFSSTPPKPSTPTPSSTISVPTPFQFSFGTVSSPKMVTTQQIASPTLSGPSTASTKQQPTSQSASVVLPSTNTPNKDRRSTSATRSESKSVSTDQENSNNEESDATSDYESTSVHEDHIPKAHLRLLEHRLDLDELNEISTTPLFTEPVRKYANAIAKTARGQKPFTQYGLLGGDIGSLESEEPANPDPRVFWNIAAPSSFFICGSQGSGKSHTLSCLLENAMAPCEANVLPHPLTGIVFHYDTFISDTGGSPCEVAWLSSNPKIQVRVLCPPTNIRTMRKLYSRFANVMIEELRLNQSDLDTKRMLDLMAVSSGASMPLYLHVVNRVLRDLRIEQQEKGGSFDYAAFKRNMFAQELTDQQLAPLKQRLDTLESFMVEQHAKAYEKGREAKSKKSTRASRGNDWTPRPGMLTIVDLSCPCVTAEMACSLFNICLSLFLEQDCNSIGRVIALDEAHKYMSSDTGSAECRTLTDRLLETIRLQRHLGTRVIISTQEPTISPKLLDLCSVTIVHRFTSPDWLRALSKHLAGVSKGGRMLEKALAMNQNRADDEGIDNVGVNTLALGYDDPAMELFSKIVALRVGEALVFAPSAIMGVQKATPRPPSTSTPATKPDGGIEGLQSQLELFDLGPQSASDKQHQETVTSATATSSGTEKPPSPTSATSHATVKRLAHGVLKVRIRNRTTADGGRSIMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNQ5</accession>
    <name>A0AAE0JNQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_29319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686294.1">
        <property type="nucleotide sequence ID" value="XM_062823041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNQ5"/>
    <dbReference type="GeneID" id="87860195"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="220" mass="24552" checksum="E76CE24A6A268221" modified="2024-05-29" version="1">MCLTYLVTTRGGETSYPNQQGHQKRGKEHHDGSLTDQEITKSRKSTAESREGTKILPLLPHSPISFPSYDLHGGHQVRGYRHGPGPEGGTEKGNFSTRRMKTPEVKVLLATNQPTPSKTATPLCSLRERDAKEGLDIRRESFSGIEHNSTVVKYRKSVCLTRKHTQIQMLVSLSCYQDSGRSTQRIKGAAQRAVGSGNTRKTRETDKWQLDMTYVIKLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPH5</accession>
    <name>A0AAE0JPH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUR7/PalI family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_505218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686669.1">
        <property type="nucleotide sequence ID" value="XM_062827974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPH5"/>
    <dbReference type="GeneID" id="87865128"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="270" mass="29883" checksum="0E6833839955450F" modified="2024-05-29" version="1">MNRTRPLLALLSLLFLAISLVLLWFVILSGITRTSPLRQTYFLRADTSGISGARAVSQWTYFKVCGLNNQDCGPARPALPLGDAWDSNPSGAPAALTGKYGGHTTSHYFWYMWRFGWVFFLLALFFETLAFFSGFLACLGRVGAAVSGMIASLALVMLSVAVALMTATFVKMRNHFNRDGRDAHLGRYAFGFSWGAWAALAISTVLFLLAMLQRDKNHYNNRRSTYATNGHDHVVADGPVTGTGGRKRGVFNWGRRSGKSFDGRRVKDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPH9</accession>
    <name>A0AAE0JPH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_31111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686356.1">
        <property type="nucleotide sequence ID" value="XM_062823300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPH9"/>
    <dbReference type="GeneID" id="87860454"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000510">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="9">
        <location>
            <begin position="190"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="349"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="392"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="570" mass="63071" checksum="6098531EE149E44E" modified="2024-05-29" version="1">MPKTQASPEGTAAEPPHPKRRRLPDDDASSMPRYSSPAEDMNRDEDTTGFEGRSRAHRPLARRDRLSTSPNRARDASASRSRSRSGRSRTKSISPRSDEDEQQRRYRSRSSSRSRESRSRSSSRSRSRSYSRSPTRSRSPPSRSRSRSRSRTSSTRDRSRSVSPSRFQDRRSSKSHAEQLRPNYRPRLELSGHTAAISQVRISPDGRWIASASADGSVKIWDATTGHNLDTLIGHMAGVSCLTWAPDSNTLATGSDDKAIRLWDRVTASPAHACGDESNRGQGPREYIRGGSQLRTARGGRTGMGPLLGHHNYVYCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCCDGTLVVSCSTDGLIRIWDTSTGQCLRTLVHEDNPAVTNVCFSPNGRFVLAFNLDNSIRLWDYVSGTVKKTYQGHKNSGFSIGGGFGVVTDNKDTQDDYRHGNRGKPFVVSASEDGDIVMWDVVTKQIVQRIEKAHEGVCFWVDVNGDTMVSSGQDCTIKVYKNVRRKKDDRRRKLDKPNDISAIDGTNGHGNGRGIDSDEAMGDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPL5</accession>
    <name>A0AAE0JPL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_504740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686092.1">
        <property type="nucleotide sequence ID" value="XM_062827942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPL5"/>
    <dbReference type="GeneID" id="87865096"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="204" mass="23441" checksum="7A44E8BD90FD5A02" modified="2024-05-29" version="1">MIPLKTYGEYSDLVISCGGREYHMHRAIVCTQSEFFSATCRGSFKARKIDLPDDDPRLVHIMVHYLYHFDYDVRLQHERSGFDGLEMDGYETNVNEPAADALLTHAKIYALAEKYLIRGLKAVALRQFKAAATVSLDIDDILGAALVVYESTIEDDRGLRDVVVETLCKHSEWLDEEKVRDVVKELGALTYDIVIYMRQKHRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPT2</accession>
    <name>A0AAE0JPT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_41229</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686633.1">
        <property type="nucleotide sequence ID" value="XM_062823844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPT2"/>
    <dbReference type="GeneID" id="87860998"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3355255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="362" mass="38924" checksum="4CF013903EE96024" modified="2024-05-29" version="1">MSQFPTRNVGVLGCTGSVGQRFILLLQNHPVLKLVAVGASSRSAGKQYRDAVRWKQSTPISPEFGDLVVRECKASEFADCDIVFSGLDSDVAGDVEKEFQHANIAVFSNAKNYRRDPLVPLVVPTVNLNHLDLIPHQRKTLGLDKGFLVCNSNCAVIGLVAPFAALQARFGKIDTVSVVTMQAVSGAGYPGVSSMDIIDNVVPFISGEEDKLETEAQKILGSLNADATAFEDQKQLRVSAACNRVPVLDGHTACVSLRFAQRPSPSAEEVKEALRSYVSDAQKLGCPSAPEPPIKVFDEADRPQPRLDRDLCKGYTVSVGRVREDESGIFDIKFVALSHNTVIGAAGSSILNAEAAIFKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ48</accession>
    <name>A0AAE0JQ48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_415766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687102.1">
        <property type="nucleotide sequence ID" value="XM_062824002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ48"/>
    <dbReference type="GeneID" id="87861156"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="469" mass="51270" checksum="647F202BD6E3B9E8" modified="2024-05-29" version="1">MQLDAFVTRTSGLLSRIAASASFSLKSDQATFNRALVSWLKDPDSSLPNGHITGLCCSSLLSIQFPDESRGNDIIPEFRSFVLAASLAHRGRRNSKGSSSRQKQAYPARHESRSHLIRRLDGILTPQYLSNLSPEPCQVLFHLVLGAVLGMGYSPSPTTTITTFNSSSSSTSPSNLLSSEFQQSPTLWLSTKNQLVRTLAQDLVFLGSTKLGINLEGTTDLEQLIIDTAISRWNEMESRIWVDSIAEKASTSTGSSQEPQQPKPASSSSPSSSSSSSPSKSSGCDCQRRQSSSSTATRSPAEAKDDDLLDQDRNPPYWEDPPPTPPPPTVEPTLIPVMPPYHDTPHAHFQFQFQAAAAPSHCTSSSWSENPASYLEMTDEPESYYLATANENNKRGRASPPMPTTTMGMPRSMTDPFPLGSPAEDFGSWRKVKRRTMWVVRTIDAGDQGQIGVHARLRGREVNDFGVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ97</accession>
    <name>A0AAE0JQ97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_451773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686746.1">
        <property type="nucleotide sequence ID" value="XM_062826072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ97"/>
    <dbReference type="GeneID" id="87863226"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041782081" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="305"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="466" mass="51788" checksum="5EE19AAA2A29D973" modified="2024-05-29" version="1">MRTLLSFLLLALASVVAAISTSGNRLLVVLDDVADKATYSKFFADLEEREFKITYETPKSDSLNLFNLGERTYDHVLFLPVHTKGLGPNLTPKTLHDFVNAQGNILLALSANTTTPTSLVSLLSELDITLPTDRNSLVVDHFNYDITSAADRHDVLLLPAPKPVRTGIKDFFSEDAGTKLIAFPRGVGAVLGNGQLLNPILRAPRTAYSYNPKEQAEAVNGDDLFAAGQQLSLVSTFQARNNARVTVVGSAEMLQDKWFDASVTKLGGKPVVQTFNREFAKRVSGWTFQEIGVLKVNWVEHHLEEEGAPNDSNPAMYRVKNNVSYTISLAEFAWDHWIGFNVPEADEVQLEFSMLSPFHRLNLKEESHRLAAVHYHTVFTIPDQHGIFNFMVNYKRPFLSNIEEKNTVPVRHMAHDEWPRSYAISGAWPWIAGIGATVSGFLGFVALWMYSAPVGAGKKVTVKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQA9</accession>
    <name>A0AAE0JQA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metacaspase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_56726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687114.1">
        <property type="nucleotide sequence ID" value="XM_062830361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQA9"/>
    <dbReference type="GeneID" id="87867515"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="145"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3355736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="440" mass="48140" checksum="C7EBD66E1BF6ED58" modified="2024-05-29" version="1">MSYGYPGQGYGPGGGHHQPPPPQWDDQQQQHYQQGGYGYSNPGQGQYNPQPPHEQGYGGYHQQPPPPQYNEGQYPPQQHHQQGHSQRPSGPPPDGYDTYGYPIGSGHQARDQGQHEIHGIPQGTQQFGHGAPENYSFQYSNCSGRRKALLIGINYFGQDAELRGCINDTKNVSAFLVENYGYKREDMVILTDDATNPLLQPTKENMLRAMQWLVAGAQPNDALFLHYSGHGGQTKDTDGDEEDGFDEVIYPVDFKTAGHIVDDELHYTIVKPLQPGVRLTAIFDSCHSGSVLDLPYIYSTKGVVKEPNLAKEAGQGLLAAVGSYARGDLGGMASSLFSVAKTAFGGGNEAYEHTKRTKTSPADVIMWSGSRDDQTSADATIASQATGAMSWAFISAIKANPKQSYVQLLNSIRDVLETKYTQKPQLSSSHPIDVDMLFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQI8</accession>
    <name>A0AAE0JQI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_486283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687250.1">
        <property type="nucleotide sequence ID" value="XM_062827690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQI8"/>
    <dbReference type="GeneID" id="87864844"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="348"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="894"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="955" mass="101983" checksum="992935536D60E20A" modified="2024-05-29" version="1">MGPFSSASDRNSAAATAAPATATPSPQSKTPSAAASDDSTTSKKFLKRLNILPLRSRTRNIADFHIRPDDPHRKYSAGDHVQGAVVLTVVKPVRITHLTVLLHGYVRVYKGPSAQNNEPVRSPAEIQNISSRGERKKYYNGYASLFQDEQVLSSDGRLEPGRYEFNFDLLFPANGLPSSIDFERGTISYMITATLTRPTSVTPTTSCERKIYLVEKLDVGPLAPPKAQTVDLRPISKRSKKKRPAGGDRRSVISSERLSADVPEPLSDADSARINDTSTEGSLSVVGDDVGPEAFSQTPRSVSHSEVRSLSGDSAASLSTHPSRAHSETNQLAIAGSAMTGKRISFADERTITMTVEVLKGGCLPGDVIPVKVSVNHIKRIKSMHGVIVTLFRQGRIDSSPLQLSKQDWKKSESDDYYYPKSRTGLSGLSLSSAGSCSMFRKDLSQAFAPLITDPVTYSATLTASVRVPEDSFPTIKGVPGEMISFKYFVEVIVDLGGKLANHLQGGASSASRVGATGVVGNPFENVGTLPSWGATGSTSILDTDRLKRIQGVIPGYYEVIVGTTDSNRLRGKGPQRPSLTLTSSVTVGPSYVENEYNEKGGWPNSMHDDDGYGPESANPDDDYASYPPQTTHPHDYVHQPPYWNYVPDSSQHEQEIPAPHYIPPPNLPGENSLTEKERIRRAEQRLLPSQPPIAAASSSSSAAVPSPSASNHAVDSSLLLNGDNIYDAEDDVPTPAATPATAPPFDHALAPEYTPTPAEDLPSAPTLEELDRPPPISRGPSHHPLSATEDKQELERRRLLAEASAPPEFPEDYIPDEGGGPVTPAGPSGSGAGPSAPPSAPPAAFEPSAPVFFEDDEDYHGGGYTAGGPSFPSGSGGHEEETVPEYTYNNHRSGSVGTVTVVGGPSSPAPAPASALFSASGSGHAHDPLREQEQQARSDSSSPPPIEYLPRYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR24</accession>
    <name>A0AAE0JR24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCCH zinc finger and SMR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_59883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687211.1">
        <property type="nucleotide sequence ID" value="XM_062831152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR24"/>
    <dbReference type="GeneID" id="87868306"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.110:FF:000002">
        <property type="entry name" value="CCCH zinc finger and SMR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="606"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="80715" checksum="47648EF61AB90CE4" modified="2024-05-29" version="1">MVSDETYDICLPVLEDPDLDDEEKTDKLQDLLREKTTLSGQALDNAVLDAMWRFRDGGGTATSPPSIRQSILRRPSPAPWRGSSTPLSSSPRLSVSPLAPPGYVPTTFGRAMSSTASPFGSPRPSPRLAFATPVPHSPNLNAYQFAANDEPPSQEVFGDYQSDNVDWLVSDDDRLSVTSSIGGSSGLNVAAPEFVSTQQADMSPFDMLRSILGTSKTDDEIGAALAMHGYDLSATVASIMDDPAQDDISLSGQNDEAKVVVIGKSMTPDQRPATPADQQRSGVICKFYLSTGQCLRSDCRFSHDLSNHICKYWVAGNCLARDTCVFSHDPAHLVNKLHIDGSGTPPTHYSTVNVQDYNSFPSLQPGTPEQLPVFPASANTPAVGITPPPGFKGHHNYGYPDRPRSRPGSRHQQKEVQQTVPSPDDADAFPTLGAALAKQSKKHHGKRGGHGHTGSGSSSSKEIASPGPSTLADIVKMSPSPVNINLRPNGKLGRNGSSTSIRNGENSAAAQAIPPPKHIPWLETGEKANKAYLKARQEAIKHGGLRNKFLQSAAQAWNRNDARAAKALSLRGQSENDLMRKAHREAASLLYEERNKNNGSCPEIYVDLHGLHPEEAVEYLVGILTENTNESRPIYAITGTGHHSKNGKDKVGKALRTFLNEWRYAYREFSVPGDRNSMGGILGIDARSWDKSLSQDGVSLVKKDEPKDDVDILSQGVEIGEGKVKLLVRDPMATKEIPKGPASHRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR43</accession>
    <name>A0AAE0JR43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_544713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686842.1">
        <property type="nucleotide sequence ID" value="XM_062829314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR43"/>
    <dbReference type="GeneID" id="87866468"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="162" mass="17491" checksum="DA09947C101619F1" modified="2024-05-29" version="1">MISIGGILHLHAPLPLAAYSPGTGYPQEAKLKKHEGALEGRFRPAPSTGIVTTVRRWTVGLSTPWVQISPLTLEGATPTIGPRGEIQPMESFRCSAPERLLLGTKGTIPAHAAARLISDDDDNNDDNDDDNDNDDDDNDDNDDAPLARPRSQQIMRKESGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MJK0_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_334408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677013.1">
        <property type="nucleotide sequence ID" value="XM_062823550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJK0"/>
    <dbReference type="GeneID" id="87860704"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC transporter E family member 2"/>
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    </dbReference>
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        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="246"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="509" mass="57574" checksum="16833E9ECADB7F1B" modified="2024-05-29" version="1">MPRPGNVLGLVGTNGIGKSTALKILSGKLKPNLGRYDNPPDWEDVIKYFRGSELQNYFTKLLEDDLKAVVKPQYVDQIPKAIRTPDKSVKFLIEGRRSLDNLDEVLDTLELRHIYDRDVTLLSGGELQRFAIGTVCVQKADVYMFDEPSSYLDVKQRLSAARIIRSLLRPDDYVIVVEHDLSVLDYLSDYVCCLYGQPAVYGVVTLPHSVREGINIFLDGHIPTENLRFRDESLTFRIAEGTEEFIQEKSRAFKYPAMEKTMGNFHLSIDAGSFSDSEIIVMMGENGTGKTTFCRLLAGVLKPDGTKRVPEMKISMKPQTITPKFEGTVRQLFFKKIKAAFLSPQFQTDVVKPLKLDDFIDQEVKHLSGGELQRVAIVLALGIPADIYLIDEPSAYLDSEQRIIASRVIKRFIMHAKKTAFIVEHDFIMATYLADRVIVFDGKPGIDAHANKPESLLTGCNTFLKNLDVTFRRDPTNYRPRINKLNSQLDQEQKLGGNYFFLDDPEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MJM2_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677088.1">
        <property type="nucleotide sequence ID" value="XM_062831130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJM2"/>
    <dbReference type="GeneID" id="87868284"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="342" mass="38338" checksum="9AC45E100C57DE2A" modified="2024-05-29" version="1">MSSRGDVPDSLRENIFMLHMAIHLRFCQLKFIFGDEDDDDVEPNNQYFELVELLKIASAIYQCERFQLELYDTPEYRYPIEDQENKDVDRPVYRMFPPGTIQEIRQEIWNEEHHQPAPFYDEHQQFPHGEGDAYSDNGNVHGNPTGYDGERARLNGLTNGLANGHANGHTDGHANGNANEHTNGHTYGNLIEVNDAVIRNLARHNIGDTNMNGVTNGLTNGYTNGLTNGHMNGNFNGYTNGNINDSTNLGDRVNELPNVSGTSASAVNSQLQPPPFRPQRQHPHQPPPQLPVQFPPEPDHQRQPEVSRAIANNCVATFEIIDGRIAHGNIVESDIVDSDMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MKW0</accession>
    <name>A0AAE0MKW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_446560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677030.1">
        <property type="nucleotide sequence ID" value="XM_062825800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MKW0"/>
    <dbReference type="GeneID" id="87862954"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="115" mass="12498" checksum="D5153DBCF52F5488" modified="2024-05-29" version="1">MASTNPTMPKVSNLPPVPAGARSGYLSPTKEEMLADLRRQLDDTNSDGVSSVDSRGRRRRRNKGAVQKQGGLNGPQILPRLADTKPVRLQLGLNLDVEVELKARLQGDVSLTLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMG7</accession>
    <name>A0AAE0MMG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_434120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677492.1">
        <property type="nucleotide sequence ID" value="XM_062825110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMG7"/>
    <dbReference type="GeneID" id="87862264"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="101"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="405" mass="45548" checksum="A735832BFFC9E05A" modified="2024-05-29" version="1">MTGSVANASAASGTEVGYPNGHLGHLKPEEQEALESFKTYLAEKGYYKPGPPASHDEQTLLRYLRARRWNVVDAFKQFKETEDWRKANDLNVLYDTIDLEAYEASRRLYPQWTGRRDRRGIPLYLFEIRHLDSKTVSTYEKAAETNPSKAVTDGQTSPKLLRLFALYENLTRFAQPLCTELPDRAHATTTPITLSTNIVDVSGVSLRQFWNLKSHMQAASQLATAHYPETLDRIFIIGAPSYFSTVWGWIKRWFDPITVSKIFIVSPSEVKATLEEFIDPKNIPKQYGGELEFTWGDQPKTDPFIKETVRWENGLKDFPEGPKYWRPTADGTRMECVAVGSEGGKQRMVSVGTVERICNVKEVEKKVNGDAETLAEEVKGLSVGDDEKKEVVETGEGATVPAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMV3</accession>
    <name>A0AAE0MMV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_581412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677406.1">
        <property type="nucleotide sequence ID" value="XM_062830815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMV3"/>
    <dbReference type="GeneID" id="87867969"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3337955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="143" mass="16127" checksum="E572A695C5DF64B6" modified="2024-05-29" version="1">MERRMCNLAYFQLCSHVYQQLGEKRDISKDLSAGITKLSKDLRAWDVPKMSDSLLVATIGTLRDEKYNRFEDPVQVMPPKDLDATVGAFLQPGKVAKLVANEQFDDMFDAVSLEVEGERERNRKERPEVLEALAASANHPDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNJ5</accession>
    <name>A0AAE0MNJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_294154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678602.1">
        <property type="nucleotide sequence ID" value="XM_062823052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNJ5"/>
    <dbReference type="GeneID" id="87860206"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="80511" checksum="B67D50F1AF811B8A" modified="2024-05-29" version="1">MANLFMTNEELGKKDDDHKRTKIPPIRSSYWNAARIPPRKTLKRLAIALTVAIFVYLFIHNIPTDNPIRDHRHPVYRPVPAQHPSNAPSVPKLNPDRPWKPPTKPETVKQKPKPVPEVDLKPVSDVGYNGPITFPNLAVSLQAIYETQGTSPKNKNILFAASSLKSAAKLLPMACQMGTELRSYVHFALMSRSDIDIEQLQAINGIDQSCQIIFHDARLDKSTESTKTRLSKGISRAFHHVQTYMHPQAVLVDASGEEEEYFLSAARAQASEEGFPLIELPEGTQKRLAWMTKLDSASLAAWNKVNVEILVYASLGTSGSLIRLLKSLSAADFTACAVPHLTIELSHDIDAATTQFLQDFQWPPSRAYNPTHVRQLTLRHRIPRNSLTEEESSVRFLESFWPANQHSHVLVLSPNTELSPRFYHYLKYALLEYSYSVPATMQQWDSRLLGISLELPSTHPGDALKPFSPPSASKKATTAQQKQQKKTPTENNTPFLWQAPGSNAILYSGQKWTELHKLVSKSLEFVHQQQQAATTSSNPALAFFTQKQISKHYPSWLEHALRLARARGYFTLYPSPQTARNLATVHNELYRALEEYRGSSGGGVGDGNDSGSWSELGKQKEEISLSLGSLLDSLPAGGNLLPFGDMPLLDWEGKMTSLAEVDRRAGEYVDEFRRALGCGKLEKGKSQMNEGEDEEDEEDERDILASGVRRGGVEDLFCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNV1</accession>
    <name>A0AAE0MNV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_479382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678004.1">
        <property type="nucleotide sequence ID" value="XM_062827528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNV1"/>
    <dbReference type="GeneID" id="87864682"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3338553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="215" mass="23552" checksum="4AF2DA3A60F790DE" modified="2024-05-29" version="1">MAQAGGSYNNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNMYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFQNTRKWIDDVRAERGNDVIIVLVGNKTDLNDKREVTTAQGEEEARRNNLMFVETSAKLGHNVKTLFKRIAQALPGMEGTGGEGGAGSGGQGGGAATRIDVSSKETVAQEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP68</accession>
    <name>A0AAE0MP68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_252213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679158.1">
        <property type="nucleotide sequence ID" value="XM_062822482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP68"/>
    <dbReference type="GeneID" id="87859636"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="256" mass="28291" checksum="1A4C686AE7729DF7" modified="2024-05-29" version="1">MGGGKIDVYMDIVSLYSYLAFLDLQRNGDLLKAYNVEVEFHPVLLGAINVGSGNKPPWSLPAKAIYGAHDARRSIARFPGLVIQTPKDLMAVSKTIVPNRALHFIKSHHPPSTFLTTLHYLMHLFWSPPNLNLTLPENVAKALLECPADFTSSSLSTPAVAAQSGQGEKKLFTKQQVEEIIKGTETPQVKEALKKATQEALDKGAFGNPWFWVTADDKKEKGEPFFGSDRFHFIYKFLGLPFQDVTLLPPGGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP97</accession>
    <name>A0AAE0MP97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_510540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679337.1">
        <property type="nucleotide sequence ID" value="XM_062828408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP97"/>
    <dbReference type="GeneID" id="87865562"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26001">
        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="87145" checksum="006A43BCD5F1583C" modified="2024-05-29" version="1">MSTLTQPQMKGIHVDMVNAPAFQEPYERVSIGDGAVSIELQRYRPSTKHAMSVERLLTNVLRLYQDVHDDDRTEQLYSTTTTLLTHLSNPLNITVLTSQLLNAPAIWERGDGMRACYRVISIFNSAATHVRKKELEAAKLSEQAKHKQPPQPLPLQTHPALSRASQGPPPGSTGSQAGPPPVPQAPRTGGGLSCDDWVSAVLKGADDKSSRWQHLLVFCGVLLGMTSQKDPRNRHGLSYSMRNTVEQAIVTAVNLALRPNEQPHGQHREPEPPAPPGPIALALTYAFPLLSKSSRLALDCDAIVPVALNGMTGADGLQDGLFLCTIDGDLKQSGNHFTWQESSPSALLLRQLEQKPLVNGLGPLSKVVGFAIEHARDANVVLQAQNDLLTFTQRLLHEWEASKLSEIEISEEEVFLTQETLQGPWVALWTLLRKVMYGSVAVLQTIVARSLLDPRMRNDTMAPVVASKTLKALRYLYFISSRNGSDAFQVYTFTYLTSVDNLARYSDACAAFLRDTKPLNPGTIPPHPLHRTLDLFYLNVAEHLPLKLTPEDCDSLIVQPAMAYLTHHSTPLSPRMLELFEAAHSAVLSVLSCPHNAPVTVKLAPFYAEALFSAFPTYISPRQFRLAFKTLMQILSPPYPISSTHPQLAETLLEMVRFRIGVASKVPLPPPETHVQSATPELPVSEQSTLVMTLIDSLPFLHLRIFEDWLTLAAHAVNQIEDVAMREAAKRRFWEILVSGEMDVERSAIGVAWWGTKGGRQAVLYGSQGGLPDVPMMSGAIQNNMDRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPD3</accession>
    <name>A0AAE0MPD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_510629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679442.1">
        <property type="nucleotide sequence ID" value="XM_062828419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPD3"/>
    <dbReference type="GeneID" id="87865573"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042090206" description="LysM domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="221"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="487"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="606"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="696"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="744" mass="78380" checksum="7A0EC4C2FA8C40EE" modified="2024-05-29" version="1">MSSYSCRRTTAALLALSSSFATLVAGQFQITPTGTFAGLGLAATCESVLYQSINCDAYVLNLGQKVYHGSPGNKTFTDTICSTTCWTSLQTARRRIVGACAQTPDLFPGYPVLTLIDPVVSGWNETCLKDSDGGYCNTKIEAFPEVESIEDMPQAQLCSFCLGAKLRLMQSSPYSAYDELHAERLEYINKRCGAGTGGSTSPLPPAIQPNGTTPDTCVSGNKYTVKNGDTCNSIALTNAVSSSTLYYINPELLNCSAPDVGLQLCLPDRCETTYTVKEADDCVTIAIRAEGSAASSWQDLVAWNAGLDDRCSNIWSPSSSPRYWGNVICISAPGGLPSNPGTEPGNGSGTGNGDIGGPGGSGDGYVDFPVPVPTGGTIAQGTTTLCGAWVQAQSDSTCSSLIVGTAVSISLWLLANPSLREPVNCSKRLRVGSWRRRFLLVPQAAHCPVQSFQLFFGALFLAHGVWSQFTVPPDTTADPNTIKTCTWWHVAESSDSCASIASLYGITSEQFARWNPSIATACKLTVGNSYCIENNFGQDDGPGPSTSSSTLVGTTTVSVTASPTTGNGISTPTPTQEGMAATTTSSGNGITTPTPTQAGMVGNCDRFHLVKSGDQCDTIASTYGITLANFYSWNPAVGKSCESLWLDTYVCVRTIGFVPPKTTTTTATTRKTTTTTAGGVATPTPTQPGMVSGCKKFHKVASGDQCDTIATRYGISLANFYSWNPAVGSSCKSLWLDYYVCVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPH7</accession>
    <name>A0AAE0MPH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lung seven transmembrane receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_590685</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679488.1">
        <property type="nucleotide sequence ID" value="XM_062831074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPH7"/>
    <dbReference type="GeneID" id="87868228"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042061581" evidence="9">
        <location>
            <begin position="21"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="182"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3340546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="555" mass="62439" checksum="AA18B53C4EB8D0F8" modified="2024-05-29" version="1">MRSWAYAFFLLVLSVWTAQALEVKLDETEENRQRCAGMYSKETWTGPVNPFISVKFTDFGSDAGDDPIVSLLIFEWQDADLVGVLPEGADRRIGICEPQYVDAGYCNTTNVGEYILAPNATALSKNIVFTDAIHLKKSAPVKYQIKNTGYYCVLTDKYTADRYEALVEFRNAYGELPATQIPKLPFYGGITILYALVLALWGFLYFQHRSDILAVQNYITAILIFLVIEMLMTWGFYDFLNRHGSNLGSRVLLIVVAVLNAARNSFSFFLLLIVCMGYGVVKHTLGRTMIYVRWLAIAHFVFGIVYAMTGLLVNPDSAGPFVLLIILPLAGTLTAFYVWTLNSLSWTLKDLKERKQHVKEGMYKKLWWCILISILVIFGFFFWNSFSFAQASDPGYVPFHWKSRWFILDGWPNLVYFADVAFIAYVWRPTANNKRFAMSDEIAQDDDGTIEFSNLDIGAPDDSDDEEAQVGMKAKKNQNENAGVGSGAGASLQQQSRNLGGPSSSSQQQQQQQRRPSPHRDSMDGETIFAVGEDGDKFSSDEDSDEEGNLVRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPM0</accession>
    <name>A0AAE0MPM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_301961</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678844.1">
        <property type="nucleotide sequence ID" value="XM_062823148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPM0"/>
    <dbReference type="GeneID" id="87860302"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="210"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="526"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="707"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3339484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1181" mass="132564" checksum="1F0055BC42A14719" modified="2024-05-29" version="1">MDDLESLELLSLVSKVTSELQNHLGVSEKTLAEFIIAQRVECASFDEFKQKLATLGADFPPSLVESIDRLVLTLHPKFKGQNHGQSRTDENEKHGQSAEEKTKVFKGLSIPDKEVDVIDDTLALLESLEPKRAEKERPRKRSRTPERDDYAEDYGKRKRKERYRSRSRSRSRSRSISPPRGRRKGRYDDEYDGDFRRPPPRETDDAPILYKVYQGHVTGIKDFGAFVNLHGVKGKVDGLVHISAFGQRVNHPSDLLSKGQEVKVKVIKLEGGRVGLSMKDVDQETGMDLAPQLRIGSGANMEALGGRGGYDTKNVVTNGFEDKGAFQATANARQHKKRMTSPERWEIRQMIAAGIAKASDYPELEEDYQATLKGEGQMELEEDVDIEVRDEEPPFLAGQTKQSLELSPIRVVKAPDGSLNRAAMAGTNLAKERKELRQQETEAKKAEEKKVDLSSQWQDPMANPETRKFASDLRKSAQAAPAAPDAVPEWKRAVAPKEVSLGRRTNMSIKEQRESLPVFAFREQLIKAVRENQVLIVVGETGSGKTTQLTQYLAEAGFTNNGMIGCTQPRRVAAVSVAKRVSEEVGCQLGQEVGYTIRFEDVTSSATKIKYMTDGMLQREILIDPDLKRYSVIMLDEAHERTIATDVLFALLKKTMKRREDLKVIVTSATLDADKFSEYFNQCPIFTIPGRTFPVEILYSREPESDYLDAALTTVMQIHLSEPMGDILLFLTGQEEIDTACEILYERMKALGPNVPELLILPVYSALPSEMQSRIFDPAPPGSRKVVIATNIAETSITIDHIYYVVDPGFVKQNAYDPKLGMDSLVVTPISQAQANQRAGRAGRTGPGKCFRLYTEAAYQSEMLPTTIPEIQRQNLSNTILMLKAMGINDLLRFDFMDPPPVNTMLTALEELYALAALDDEGLLTRLGRKMADFPMEPALAKVLIASVEKGCSDEMVTIVAMLNLPNVFYRPKEKQAQADQKKAKFHDPHGDHLTLLNVYNSWKNNGYANPWCFENFIQARSMRRAKDVRDQIVKIMDRHRHPVISCGRDTNKVRQALCAGFFRNAARKDPQEGYKTLIEGTPVYLHPSSALFGKQAEWVVYHTLVLTTREYMHYTTSIEPKWLVEAAPTFFKMAPTDKLSKRKKAERIEPLYNKYAGADDWRLSAQRRGGRGGGGGGTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPN2</accession>
    <name>A0AAE0MPN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_471977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679266.1">
        <property type="nucleotide sequence ID" value="XM_062827126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPN2"/>
    <dbReference type="GeneID" id="87864280"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="320"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="476" mass="53342" checksum="55396B5DE4C6FFA7" modified="2024-05-29" version="1">MSVFLPPETITVKRRKRGAEDAPVDFLRVEGSKRSRNGEGSWVYRLKQATDIIAPQPTIPTIQTTKEGDEKRRIIKPLPRPRSQRITPQPDVTPSTEPTSTSQTAKEPTLRRFHLSKTIVSQAATSGPVSKKRANTAIFVERSSKRKSLHENQALEQSKPTSVQNGPAALQPKPSTGYTYQEPPPADPNDTGVKRSYKRPGTRRFQPPAESSKPGAHPALPPSLVNRNVNVDMDQLAQEMDAYTLSAITSHLSKLDEASAKAAERKAKFKPKAPALRYAQRHPEAAAAAAPTKEAAPQATAAAPVDDDMDIDMMDTSDDDEYVIEEYYRVPASRLNEEEVAATQVGLLVFDSEPDKTEFFFGTEEDDEYEFPEDEDDENHENYYAADYPDEDLEWDDELDRNPYEYVTGNASDREEFDAELDDNDDDDFVKADERFMDHVWQTSNEMADMVAYARGYDGDRPEPAVAGFPRGFPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPS4</accession>
    <name>A0AAE0MPS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_578914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679803.1">
        <property type="nucleotide sequence ID" value="XM_062830742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPS4"/>
    <dbReference type="GeneID" id="87867896"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="571"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="790" mass="89631" checksum="E925928FA901E280" modified="2024-05-29" version="1">MATLVEPSVPTTSSEERILALEKRLLDLDLKYQTLLKSFESPSPNAPTQEGVENTEPSASSTTSGGVISSSDAGTLETKADHNGHSRIKIVRTYKNPDTGEMIEKEDNPTPKAEDRDQVAFILKKVQADKLPGSDDRSEIDIISLDLWNLLKKHLAATPGHAFRGQPITIYSPFEAFVHNFDRLQTVAADVNEKDNEQQKQARKDLQLLLGAISDGSSGDEKLNKYFKMRDSYLSDDTIQFDDLWTIFRPGTLVYGKPFQGEDQVFVVADNWYCWPQRGDRPTTWLAWPLACWVYDWTGTEFKRTPFMMRIESFEGRKPITSLPDSELRTVKASLITKGKRFRKYCEAKEGLRMFDYKGDAIYGMKGFIGMSQGVTDDSDARSVRSYYDQLERLRRRRTGEDADISTPRSEYTASRVMVDYLSYFQYGSSTKRLGGLESKTQTWMDCACSDCAKNPELNTKFRMHFDKLNIQLKKDWEEEQYLICPPRVLGYILKDKQWAQLQVTNLTEIPPSDNDNPWNTRLQLADDKKKCGTTKSLLFDLVRSHISSSTGDRNADRGLEVNDIVPGKGKGLIILLYGPPGVGKTSTAETIAIAARKPLFSISVADVGTEAKHVESNLARIFALATSWQAILLLDEADVFLESRGKGDSTDKNALVSVFLRVLEYYQGIIFLTTNQIAQFDVAIPSRIHISIAYGHLNEDQMTKIFQGFLDPLEDRDLIEDYAGILNYLDEYVYSMRFDGRQIRNIGPGKLKLKHLKTVVTNTNQFKNDFSKQYERYIEKQQSIKSFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQX6</accession>
    <name>A0AAE0MQX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_473069</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679580.1">
        <property type="nucleotide sequence ID" value="XM_062827176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQX6"/>
    <dbReference type="GeneID" id="87864330"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="554"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3340638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="700" mass="76179" checksum="B456E06925CAE846" modified="2024-05-29" version="1">MFGNNRLPAFHPGLTQSRIRDTTTGSRLWFPGLRSAPPSESSPSDSDPANDQLPLPITPEDLYDTPMAPFNPYTYIRCPCSELNPYAKRTPDVTAQGLSRAAQDDDDHTFDPRAARSNYSLYPLEYLSFCEDCHQIRCPRCVAEEIVCYYCPNCLFEVPSSNIRSEGNRCTRSCFQCPICIGPLAVNHVETPPDPNQLLSPDHAASSHSGSYILSCSYCNWSSTEIGIKFDKPNSIHMQLAKLRNGGETRLTAKERKERRKEQASQGGGGGSSSTAHGEEDLDTLLDMETQFANLKSFYQNQLSDANGTGKAGGDASAALGNLGFDAPASLSRIMSLYTGSSSLHDKKSKSRPGTMREALAPSEGLQLASLDETSAITALQDFEPITGLDAYSSTASTTQLQSQAPYLGASPLHGLTRFTSSLRPISYLLRTKRSKRCPQCRHIISKPESKVTTTRFRIRLIAGNYIPTITIKQLIIPGLTPPPMPNLPPDTIEPLKPAQFVLTFKNPIFESVRVTLATPATTPGRFPSKVTILCPQFEIDSNTDVWEEALKDNNATSSSSQSQNLSSSTGPEGSGPGGRKRAGTLRPGTAGGASLAGEELGPEVGKVWERGRNWTSIVIEVIPASLVQTAKRDGRGPIKEDEDVLEIPMFVRIEWEAEAPEDEIMPGLSSAKGNKDGGKEKRELAYWCVLGLGRVARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR57</accession>
    <name>A0AAE0MR57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_526824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680509.1">
        <property type="nucleotide sequence ID" value="XM_062828863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR57"/>
    <dbReference type="GeneID" id="87866017"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="183"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="185"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="371"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="485"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="551"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3342716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="606" mass="64340" checksum="9DC5DCC323C72319" modified="2024-05-29" version="1">MPPKRAAATQGAKENAPAAKTTTKKLKTTTTVTKKTTAKVAKKDEEEPKAAPKAAVTKKAAAPKKAAAPKKAAAPKKAAAPKKAAVPKKTAAAKKAAATKDDSDKENSVGGGKRKRDEDEEEEEIADEKQVNGTRPPVKRTKTDEDEAAKPAPKKAKAAPKPKPEPKQKPLGKVINEAPTKVMDIFVFGEGTSGELGLGSMKYDGKKPIDVKRPRINHNLSGVVQVACGGMHVAALTKDNKILTWGVNDQGALGRDTTWDGGLRDADADSDSEDEDDTGLNPKESTPGEIDTTDVPEGTVWVQVVASDSATFALTATGHVYGWGTFRSNEGILGFTKNTLIQKTPALITQLSKIKQLAVGSNHVLALDEKNKVFAWGAGQQAQLARRLLERDDNGALFPASIGTLPGRAKAAKLACGSYHCFIIDTKGRVIGWGLNNYAELGIEAEAGTDGGFILKPQLVDSLKEHKIVDIAGGEHHSLATNDKGELLTWGRIDGHQVGHPSGSFTEENTIFDEKDKPRILVQPAVVPDIEGKIVHVAAGTDHSFAITEDGKVYSWGFSANYQTGQGTTDDIETPTLIDNSAIRDRKIIFAGAGGQYSILGAEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRB2</accession>
    <name>A0AAE0MRB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_430876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-ulmin hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680000.1">
        <property type="nucleotide sequence ID" value="XM_062824909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRB2"/>
    <dbReference type="GeneID" id="87862063"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23508">
        <property type="entry name" value="hydrophobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.120.10">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010636">
        <property type="entry name" value="Class_II_hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036686">
        <property type="entry name" value="Class_II_Hydrophobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341:SF1">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06766">
        <property type="entry name" value="Hydrophobin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101751">
        <property type="entry name" value="Hydrophobin II, HfbII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042274617" description="Hydrophobin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3341058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10855" checksum="080B6B904BFFEB69" modified="2024-05-29" version="1">MQFTIATVLSLLTVALAAPAVIERQVPYIPCSGLYSNAQCCATDVLGVADLDCANPTETVTSAANFQSTCAAIGQRARCCVLPVVSTYPESCSRQSFEGITWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRL8</accession>
    <name>A0AAE0MRL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_425483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681753.1">
        <property type="nucleotide sequence ID" value="XM_062824579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRL8"/>
    <dbReference type="GeneID" id="87861733"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="239" mass="25614" checksum="15C8B5BD64AC5B8A" modified="2024-05-29" version="1">MAFLILVIGDLHIPDRALDIPAKFKKLLAPGKISQTLCLGNLTDRSTYEYLRTIAPDLKIVRGRMDVEATSLPLTSVVTHGNLRIGFLEGFTLVSNEPDLLLAEANRLDVDVLCWGGTHKFECFEYMDKFFVNPGSATGAFTTTAASWAVNLSSNGEGQKEQDKGFDEDEEVVPSFCLMDVQGISLTLYVYQLRRDEKGVENVAVEKVTYTKPVEPTGAGGAAAGAGAAASGAASVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRW2</accession>
    <name>A0AAE0MRW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_442827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682068.1">
        <property type="nucleotide sequence ID" value="XM_062825598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRW2"/>
    <dbReference type="GeneID" id="87862752"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="224" mass="25618" checksum="92E562F1049438D5" modified="2024-05-29" version="1">MAEGERYTRLFVDRKPRLKEPVRMEDQVVRLAQPPSLAQRFLKLGRGSPLLSGCVGGQREVVVRDWRERYDVKSSRAVEPDMTRSKSGSEERKKEAEEPGQVPGPRSATKGYPQGLPFHLGGGERGWRSLTPHAGARLHCYSVRSLASFREQAGWTVKVEKWKLSIHLNLLVIRALQDKRQDERYKNSDLKLFSPSGSDLEKYARVLLEGNLFNKATYLRGFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSS9</accession>
    <name>A0AAE0MSS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_508737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681545.1">
        <property type="nucleotide sequence ID" value="XM_062828253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSS9"/>
    <dbReference type="GeneID" id="87865407"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042085846" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="45118" checksum="8C6DC226CE537274" modified="2024-05-29" version="1">MMYNTFTTGLVATLLAGAQIASAHIEMSYPPPFRSKFNPNANPGSIDYSMTAPLKDTGADYPCKGYQVDFGTPSGKSVATFVPGQTYNMTTAGTATHGGGSCQLSLSYDKGASFTVIESYIGDCPLAGKYDFTIPADTQPGEAIFAWTWHNRIGNREMYMNCAPVTIAANNKREVAGAAFSTRPQIFVANIGNGCKTDENFDVQYPQPGPNVVNAPGAPLKGPEGTCGASAAPAAGSGSGSGSGSGSGSGASSSSSVAAAPITTSAPAQTSAAAGGNPGGIFITAPSVGSDQGGIFLPSATDIVNAPSSSAAAVVSSASVSAPAVATSAPTVATTQAPIQTTLQSIAKPSATVVVSAPAPIATGTTPGNGSTVGAYAVGAACTSEGAWNCIAGTSFQRCASGAWSAVMQMAAGTSCSAGESAQLKMIAKRHLANGPKLGRYQRQRMELANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSU6</accession>
    <name>A0AAE0MSU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_427155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682249.1">
        <property type="nucleotide sequence ID" value="XM_062824668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSU6"/>
    <dbReference type="GeneID" id="87861822"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="928"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1154"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1190"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="969"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="492"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1212"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1234"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3345636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1276" mass="147497" checksum="3255A4188234A3B4" modified="2024-05-29" version="1">MRAETLRAFVDACSPRNLTHYDPEDEPTSCLSTEPHDNTVEDAVQHYFGCIEICDRAKFLKPGHPHWEHEWDIQYGKVYTELANTMEKFLVTNDNDKWENHLKAAQEKLKEAGHPVPDGDPITIDSISKARANEWLEKRMGSVAIAIEAQYKRIEILRNALSKTPTRHSRVFSGQQPAVKKEDCVVNQLEESRTRWKRSPRFIQGIQLVRQWRKEMKGENEDDDNNESDEPGRKKVKDLAKKQRTKKNTQSENGHQSNQDPSNELAEDTDTEYHLERDVNAYLIQFSTEYDTGRPSQDAGSFLTPVDEPLTDGRFKGTFPDQRISMSFLLDNGVTPGPESTDNPRLRTHDPEGDWNILSRNRCKSQDDSGPPKRIRYFHIPSNNMAWVEKAIANYYETETPDLNRKLRHQSVQTPIHMLLSPQYWRGQQQGTRSGVVHARHMRSLCEVVSTETNEIEKHPKNVVLFMPYLHWETDRRRETISRLIDIESDKFRQTQKGEKQQKKTSRQKEREKLTERSKDDMERRKIKHPKEGAEDPESQNKLLQTVDLALYQLFRRRREARRGERPHIDDSGRLIVMSALGQYLVDAARLYEAMSTFRDQRMLEKYLFHDPPLHPRRTLDQSYYWTLRTTKARDRDQVIYRDTKLDFIHKLQEAEKPKHSWIKRHSSPQQPLNRTTNSATPVTGEEPAHGPGDHGTAQYVEGDVSLLMKWTHHSETTDEHGCDQCKSDIKRVSQLIMVDQLWMWVLDEHTIITSFPRRYGSNKHDLSGVHRSIRARLKSFRKNQVRSVYDLALIILDECSNTFFDRTRADEGQPQVMDIFSEAIGRVTNQHTISFHHVWHWTQEASKIYRARSKYVSSANLHVSLLDINPEGKLQREVKDILDELDIMLHVHKRQRDIMKRFRRHVEHILDPKNRWSGDCFIEEDTLEPSRKPSGNASVRSGSNGKSEEQPGTDDEETRRRKQLGWFRVQYQELLSEVNDRIDELEGLRAGAKSTADSVNDLLALKQQQSSVVQAWESVRQAEEAVAQGRAVMMFTIVTIVFLPLSFMSSIFGMNNWEFTGGGPMHLGEQFKLMFSISIGIIIATIVVAFSPLLRATVVSFTKYVFTIIVVYSQLYRFWIMFHDEYRSEYLMYKTELKVRKMKEEVRKAKRKRAARRAELLNTQNNPDEQASDIANAASETPKRSWLSRLFGAGNSPTLEGKPSSISVSTRDGKPEVRETNEHSEQSGMRPPSTVSNGTTQVYTMAGGNTPMSRGARTPEPPLMSGRRGDDGDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT33</accession>
    <name>A0AAE0MT33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-xylulose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_507524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682504.1">
        <property type="nucleotide sequence ID" value="XM_062828142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT33"/>
    <dbReference type="GeneID" id="87865296"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="270" mass="28771" checksum="7D03148377087396" modified="2024-05-29" version="1">MSTTKGNSIPSASKLSDLFSLKGKVVVITGASGPRGMGIEAARGCAEMGASVAITYASRAEGAKKNVDELQKEYGIKAKAYKLNVSDYADCEKLVKDVLADFGQIDAFIANAGATAKSGVIDGSKEEWDRVITTDLNGTAYCAKAVGPHFKERGRGSFVITSSISGHIANYPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVDQKTQDLWKSMIPLGRNGDAKELKGAYVYLVSDASSYTTGADILIDGGYTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT54</accession>
    <name>A0AAE0MT54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_548131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683433.1">
        <property type="nucleotide sequence ID" value="XM_062829558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT54"/>
    <dbReference type="GeneID" id="87866712"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="217" mass="23979" checksum="B08AC978450EB111" modified="2024-05-29" version="1">MDHLDSPPHIHGWHRNNHRSRDRRRTRRELRACPAVTRRHLDHFVALYEDTVWVNGAEIEQGIASDTGTDEHSTHDEQPTGQVKLWTTERREATSQEKAIMDAVASTSTSTGASTTTQTKPVISSDSDTSGHLTRDQRLTAHDEIMAIMMKRLDIKTHEPGTTHSPPSTSTDTTPPTNTVTTPPTSTSAGAGTTTQPEPEATGELAQTEYNPNCFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTU1</accession>
    <name>A0AAE0MTU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_548291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683601.1">
        <property type="nucleotide sequence ID" value="XM_062829569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTU1"/>
    <dbReference type="GeneID" id="87866723"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3348519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1127" mass="125426" checksum="300360A1442EE867" modified="2024-05-29" version="1">MSSYQNGTNGHSASNGVNGKAAKSQTVIGPDPNAERTASMAKPRPTSMKLPFTGASRQGVENAFERHRQTIQSAVQPLPTQQGAGTFSENKKWGKLSSDLMTLRWADFKTLKHMVVAKIKGEKITDDKTMIMEKVIQMVSNLPSNSKLRVELTNAFLGELWYTLEHPPSIYVGEEYQYRKADGSCNNIMFPQLGAAGNTYARSVRPNVIRQGALPDPELIFDSVMKRTEYKSHPNNVSSILWYWASIIIHDLFWTDYRDMSKSKTSSYLDLSPLYGSNQEMQDTIRTFKDGKLKVDCYADKRLLGMPPGVSVLLIFFNRFHNYTCDNLIAINEDGRFNKPSPKLEGEKAEAAWKKYDNDLFQTARLITSGLYINITLLDYVRNIVNLNRVDTTWTLDPRADTGIDVGTKEGAERGTGNVVSAEFNLCYRWHSCISAKDEAWIEEFYYELFGKPGSDVNFHELIMGFSKFEGRIPADPADRPIPKRKGNFTRDANGKIDDDELAECIAEAIEDPAGSFGAKNVPPSMRAVEILGIIQGRKWNLAGLNEFRKHFGLKPYETFEDINSDPGVSEALRRLYDHPDFVELYPGIVAEEHKSPMVPGVGIAPTYTISRVVLSDAVCLVRGDRHHTVDYNPRNLTNWGYNEVQYDLNVNHGCVFYKLFLRALPNHFKENSVYAHYPMVTPAENEKILKDLKRDHLFDWSRPGRQAKPHQVTTYAGAKHVLDNEKEGAYKSSWHAGLESILGHPLNNNPDAHDSQRRDIHEQLYSAEWASQVKAFFQQTTDALLAGESYNVGGHLLVDLVRDVGNIVPTLFAATVFDISLQGKNNAKGLYTPHELYAVLAVIFAAIFYDHDPVKTYQLRDAARTVATQLGGALEAGVKSQTSFFGSLLGGSGNDNPLTAYGSDLVKRLSKAGLSASDVAFGQVLPIVASSVPSIAEGFASAVDFYLGEAGQPHLAAIQELARQPASAEADAQLLGYVLEGIRLSGNTLGAFRQASAVDAIKEEDGGEVRVQPGDRVFVSVKSAAQSPTTFPSPEDINPSRPLDAYKIFFFGTHSYLGHEVSQIALTEMFRSLFKRSNVRRAPGPQGQLKKITRELNEELSQTFYLREDWGAVTPFPVTMKVTWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV25</accession>
    <name>A0AAE0MV25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_144720</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685398.1">
        <property type="nucleotide sequence ID" value="XM_062820982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV25"/>
    <dbReference type="GeneID" id="87858136"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF3">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042097120" description="Endo-1,4-beta-xylanase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="16">
        <location>
            <begin position="36"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3352103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="289" mass="30747" checksum="9648BA21C12EF12A" modified="2024-05-29" version="1">MVAFSSILLAASTAISAVFALPGELPGQGSLFKRQTYTQSATGTHNGYYFSFWTDGQGSIQYTNEAGGQYSAKWSGNGNWVGGKGWMPGTDRTINYTGNYSPNGNSYLSVYGWTRNPLVEYYVVENFGTYNPSTGATRLGSVTTDGSVYDIYRTQRVNQPSIDGTATFYQYWSVRQQKRTGGSVNMKNHFDAWTRSGLQLGTHNYQIVATEGYFSSGSSTINVGASSGGGSGTTPSDPSTTTAPANPGNGSGNCAAKWGQCGGQGWSGANCCQSGSTCQASNQWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVQ2</accession>
    <name>A0AAE0MVQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 71-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_421448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685309.1">
        <property type="nucleotide sequence ID" value="XM_062824343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVQ2"/>
    <dbReference type="GeneID" id="87861497"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042293625" evidence="1">
        <location>
            <begin position="24"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="652" mass="69974" checksum="6749CD49E1CF347E" modified="2024-05-29" version="1">MNTFKFLVGLASCLAGLASAAQAAEPKAVFAHFMVGNTKTFTVNDWATQIDLAKTAGIDAFALNMANNDSTNDVQLPLAFSAAQQKGFKLFFSFDYAGNGAWSKATVKSMITNYGSKTEYFKRGSQPLVSTFEGTGSAGDWSEIKTATKCFFIPDWSSVGAYPAVSLANGVADGLFSWDAWPKGDQDMTTYPDASYHDALNGKPYMMPVSPWFYTNLPGYSKNWVWRGDDLWFDRWQQILSIDNPPDYVQIISWNDYGESHYIGPLDDKQYEAFDSTHGKAPFNYVKNMPHDGWRAFLPFVISLFKAGTASFNKEGITAWYRVNPNDACNNGGTTGNTANQLQYEYLPEAIIKDRIFYTALLGSSTNVQVQVSINGVIQPTTAFDDDGKPYGGIGLYHGSVPIPSGVTGPVIIKLLRGSTVLATITGSPITKSCTVSPTSGIALQNYNAWVGSALSSSTSGPYSSSIPPPSSSSCISGFGLYDFTGLCSFSCHNGYCPSSACVCHQRGVASPPSLTNTPGYPAPGYTAIYTGLCSFDCNHGYCPQPPCTLTPNTGTVPTYSPFLPPACVQGEKQAGISDAFLGLCSFGCTFGFCPIALCRCTGTGRLVDAPAYVDTEGYFKGDEGVDDHGLCNFAATHGYVPDSCGNRTRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVR2</accession>
    <name>A0AAE0MVR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_24063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686147.1">
        <property type="nucleotide sequence ID" value="XM_062822315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVR2"/>
    <dbReference type="GeneID" id="87859469"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="165" mass="18504" checksum="A4E60169603BC703" modified="2024-05-29" version="1">MDVPDITPSLEKLNVDLDQLEAALKPVLGDVGDVSSKLPLLDKAKLYVMVTYAIESILFSSLRLNGVDAKEHAIFTELTRVRQYFEKIQNIENPPQEREQTVNKEAAARFIRSDLADDEAIKQKLTELIAKEKAKAEAKEEKKRAADSSSEPIAKRPKTKGNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVV6</accession>
    <name>A0AAE0MVV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_506829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684710.1">
        <property type="nucleotide sequence ID" value="XM_062828095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVV6"/>
    <dbReference type="GeneID" id="87865249"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF72">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041929152" description="alkaline phosphatase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="671" mass="72870" checksum="A65AC68B9906E61D" modified="2024-05-29" version="1">MVSSRLSGVLALLATSLSVVHVSGQTFQRLGTCPTLGCILPPDQQDFLPGQQFDIRFEVHAPKNGSEAFNDGVPDEKFTVTIAKDNGTPKSIASFFQLKDEPSLEKWTFSWFEDLFAQDAKTPSVVNVASKIYRRVALYEPGTYTVTLNYYSGKTTTATWVVRPLATKKKAKNVILFIGDGMTTNMITAARLLGHKSINGKYQSTLQLDKFPTLGHQMTHSIDSFITDSANSASALYTGHKTTVNAMGVYVDSSPDNFDDPKVENVIELLKRIWGSAWGAVTTAFIADATPTALTAHTRSRYDYGALIEQALNGFSNTSWTKMDGPDVYFGGGAEQFLPGSASYQGKDYYAEFAKRGYSVSLNKTSLLAAPNDTRALGIFCKSNLPVWLDRNIFPENTLKLKNDPSGASGPAKDIPGQKEMTLKAIDILHKRGGKDGFFLMSEAASIDKQMHVLDYERALGDLLELDDTVRATIQKLKDLGELDNTLIVVTADHGHGFDVFGGADTKYLAAQHDKDDRHKRSAVGVYHESGLSQYTVEQPGISYNTGPNFPVNWDPRYVIAAGTGAAPDRREQYGVGKNGSRTPAVTLPGMEANDYYVNPTDRTGGFVVNGTLPTTESQGVHSLTDVPVFAQGPCSGNFGGVYSNTDVFFKIADCLGLGHPTNKTIGGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW68</accession>
    <name>A0AAE0MW68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_418269</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686538.1">
        <property type="nucleotide sequence ID" value="XM_062824137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW68"/>
    <dbReference type="SMR" id="A0AAE0MW68"/>
    <dbReference type="GeneID" id="87861291"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3355160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="185" mass="20979" checksum="46E4476E6B365C1A" modified="2024-05-29" version="1">MGNTLSIFGKLFDGLFGKKEMRILMVGLDAAGKTTILYKLKLGEVVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVVEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLSSLRQRSWYIQATCATTGDGLFEGLDWLSTELKKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWZ3</accession>
    <name>A0AAE0MWZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_47838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686811.1">
        <property type="nucleotide sequence ID" value="XM_062827478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWZ3"/>
    <dbReference type="GeneID" id="87864632"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="796"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="667"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="906"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="951"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1049" mass="111048" checksum="260661868399A5D8" modified="2024-05-29" version="1">MEQVGRETTPTATTHGVGGGGGRSGSLASESAPSNTNANSHPTNAKWGNACAQCAAAKAKCSRQSDAPGTKCGRCERLGKDCTNQVHRPRKKRAVRPSKTAQLEQRLNGLVDLLKASGDLRGIPIADSVASQEVMSAYDSVSCIARDHDLQIAVGAPQASGSGKRRASLTPLEDDRHGTSEGGYSDDESHSDSSELLGDGPIHVPKHYNSYAPSGCMCRARGEIRGPSESDETILTIYQTHLSPLFPFVIIPVGTTVQELEQSRPFLFSAIRMVTTLTSMRSMRAQMYRLVRHVSERMLLRSERSLDLLQGILVMIGWYQYHCLMHAQLNNLIHLAASLVSDLGLNRDPKVQERISVMVLYPDDPKPRTNEERRALLGLWYMASTISVAFGKLESIRYSPYIQQCLNELQESKEYETDGILVHMVQLQHLMEKIAQVNSKTESPESVGGIARAPVAAYMSTFQSELDKICGSLNKSQKNNKYLMVYVHSAKMRLCEPPVIDASLLARFYKDLTALDDNTPSALDLFYRVSSGVREWFDHWFAVPVSTYFYLPVSITCQIVYAVSMLARWSKIVSPIKPLPSSQNKNTISTTSQPQQPITTAASYCSTPTSTPAFVPTPSPHHSRSCVCNYGAGPPPDFSQRPPATSSTISTPAPATPCPGPVCSRATSTEPTSTTTPNTTITTTDQQTASNLPSKNNKNNPLSSVRWRETTDPQLPHIVAMLQEQLNSQPGLRIDITETMAQLGARFQQAGDDMKEASGGEPDSNMWEVSAKGLVMTKAKLERFAEFVAQGGKLLDDQGKEEGEGVGVGGGGGGDDVACLPPGTRTGTGAGMGGGGDGGSRRAASSFPYQEGGGGAAGGGGVGSAGAGGGVEAGRTSASSGSGSGERYAQQSALTRRGGGRGTGDIVTSSRGRGNTTATQSQSQSQPWLAGLSQVQAQGQGQSMGAPPIPQQHQQPSFQGSSYAGATSGHNMNGASIHHSLGAATAAGVHGGDAGYPSAMVGATGGGVGGAGGGWQCNNLLATEFMDQLAPWLWYYGVGDWPGAGPGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX78</accession>
    <name>A0AAE0MX78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_53589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687004.1">
        <property type="nucleotide sequence ID" value="XM_062829036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX78"/>
    <dbReference type="GeneID" id="87866190"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="360" mass="41097" checksum="CC521FCCBB033B00" modified="2024-05-29" version="1">MAQNAASRPKRGVFDFLESSWAKIFFAIVALQAIIGVTFEAYIFGKFQGSLDNYKTGQNEERDAQYMTIPTFLALFIFGFLYVLFLTWDALRWKNTIQIIGLCIANLALFVYTILQIDQINRSIDKLQAAGIFLPMETHAAVWHACSPFLFTIPPVIGVATIAMSVCAWKLYQEFAWDILKQIGADYRMKKRFLHYQIFIALLKFDFFFFLGFTIQFLVVVTGKTDIELGLTAAAIPVTIVILLCAAFFTQRENRVGMCAVIVLFFGGLAYFLFKLVRIYSKSHGWHYTPVKRSLTAFAVMTILLILITIANSFICMRNFGNGLKMHLIKPKGRDPEKDDMNSFQMTDQKPQLQTRMTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXW1</accession>
    <name>A0AAE0MXW1_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_50180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062827848.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87865002"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042044543" evidence="2">
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            <begin position="18"/>
            <end position="308"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="308" mass="32445" checksum="CDF6F7DD6F94B965" modified="2024-05-29" version="1">MRASFALLPALAAMTMASRCRPRTTTSSLATSTLTSAVVSSPTSSADPTSSAVSIIESTTTTASDEPTTTESSTLEPSTTEPATSELPTTSEPPTTSEPPTTSELPIPAPTTTEEPTTTEEPTTTSAESATSTAPSAAPTVTGFCLKAITANVPNYKYHIRALGPGSNMLTEAPNFPNLAFFDLDISTGKMTISNGEWAGYEVFTPPPFDGQNTRVIRFTDSPADIEYPFRCSNPDGVYSAGSVLKCEVTAPWGDGVNMRYATFSGSTNSPAGAWNIMRDDYVRAGAFNYDLGMFFGDVCSGENDQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZS9</accession>
    <name>A0AAE0IZS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_83297</name>
        <name evidence="10" type="ORF">B0H65DRAFT_84550</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000014">
        <property type="protein sequence ID" value="KAK3334269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676607.1">
        <property type="nucleotide sequence ID" value="XM_062831468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZS9"/>
    <dbReference type="GeneID" id="87868622"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042442699" description="NodB homology domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="79"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3334269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3334441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="289" mass="32016" checksum="F0C63A85CC3A6114" modified="2024-05-29" version="1">MRWSTFLPVGALVALGRAIPTPSKRLPTRDLYPNNYGPNNNYPNDYYPNQDTSSSSGSSPYLRRAVPTGLIINHCTTPGIVALTFDDGPYIYTTQLLDKLASFSPPIHATFFVNGANWVSAIDDESTPYPGILRRMLSEGHQIASHTWSHLDLTTASTAQRVEQVTKLEDVLLRVVRVKPKYIRPPYATCENGCLEDLEGMGYHVVNFDLDTKDYENDSESGIQVSVNKFNSELGSNPATDSAIVLSHDVHRWTVERLVDEMVGTVRARGFRTGTVGECLGDPESGWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J019</accession>
    <name>A0AAE0J019_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_74048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="166"/>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3334478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676794.1">
        <property type="nucleotide sequence ID" value="XM_062823753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0B8"/>
    <dbReference type="GeneID" id="87860907"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="90" mass="10525" checksum="F34C991D0ABBBA11" modified="2024-05-29" version="1" fragment="single">KPVKIKHTKEYTHEDCPGPGWNFKTVFCLKTLYVHHKMKKTANGFSKRGCFKCVHFQKDEEAKKRGEEGCSGCMWPKCPRYHPGLYFSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J0I8_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">B0H65DRAFT_566020</name>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676785.1">
        <property type="nucleotide sequence ID" value="XM_062830308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0I8"/>
    <dbReference type="GeneID" id="87867462"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="205" mass="21875" checksum="E4BEDA52FB6FE207" modified="2024-05-29" version="1">MADYHASQAVEGNSPPSSLGNQAVASQSASGNQADLQANGSMPNDGSVIGPQPGVAHNQAAVVEPQADVHIHPDIPPPTEDVRAAIIALATSNLPVEVQAVDVEVVEAIIAVVARLFHAENGQCRHLDEVTGEQCTARKWKVGARKCMSHLRNRPSVAKQVEILFRTLQGHGTCSGNYAWKETDDGTLCDDCAEKNALRRERAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J0L3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_582861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676870.1">
        <property type="nucleotide sequence ID" value="XM_062830866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0L3"/>
    <dbReference type="GeneID" id="87868020"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000203">
        <property type="entry name" value="PH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1244" mass="134025" checksum="28306F2B3B94CF29" modified="2024-05-29" version="1">MVLPSQRPLMESNEEIIPELQPIFALLSSHANKLYQEGYFLKLDDQDIKGRPNPDRTWTECFAQLVGTVLSLWDAAELDAAGEDGEVLPKFINLTDASIKMIESLPTRSSDEQPLQNILSISTAGRNRYLLHFNSHHSLIQWTSGIRLAIFEQSTLQEAYTGALIAGKGKTLNNIGVIMERARTPVQEWVRVRFGAGVPWRRCWCVIEPPSEKEVLKAQKEFKKRSPYDRSHGPVLKGQIKFYDSRKDAEKKKKHSKPIASITDAYAAYAIYPQAKALIDGSSLVKIEGSITIHSEPPSSTEGFVFIMPEVHPAVSGFEMLLRFLFPTWDTFALYGRPGRLVASVLDPRSLMFAMPKHKRYGYLELLDVSGLILTDGSSAWTEQQWKKKMKELTGQRMNAVEDAPSHSRSASRSSKRLSFGQNPASSSKPRVGFAEEGGSVRSSRSLSLSRPAQRTDSAPPDPSREPVPSTMAGHARHSRNISDTQLANAASAHGLDGPGAPQPNMRGPERARTFASDLASTPERVSSEDESPLRSQLTNDLQEIQRMPTPEPVNAPPAFAHGAGSRPQQQPYHSPEMRRAHNRLSNTTLSQIATAGGLPSDAVQNESNRYPEQGRGQSQGQPAVQPQASVKPMRMNANLIGTREALTSPSPTNNGPSGPSPGLTSPQNPSTASLTRFSDSPASGRATPPMTSYQGSTTDGRRTPPHSQGPPPSNMPGRSPPVTRKPLPPGSPVLRRLSEDSVSSLPVRSGRGAGGFDQQIEDANLWLTMLERQDSMRSYSDSRSIDAASTASPDYASTHRSTDTQESADRERPRAGVLKVVGDSSVSPDDGNGSSGGKTDLGIDINFGPTFNYSAMKTSSAKPTGSSAQPNRSFSPNTGRKSPGPGASYAHFRQDSDDTIRRTVPWQPGSGLKATAAHNAVSPEQFVQQRAAAPSTPVFVHQRSPSSQTVTDFRAATPSSPLRRPGAHGGSHSRHNSAELLSSGRPATSRGPAELLTPGRPASRGPVAILSGAEVSSHLSAREQEYVARVTGTPLIAMAGNKNDHQPKAGLVGAIQHRERERAQMRQGVSGQAVAHAIDQRQREQTQQAQRAAQAAYAQKQAHRVSGHFNPGVVSNGAASVYGFGMSGLDNGHMNHTGRSQPLQPNTGYGSRQPRPRSQLLAQHSSYALGDPTAAGYGAGSAVWASPPMDTPHGSHPLQSPSSYNVGGQISQAQFSMLRSTSNGQYAPGGMPGRPATPGRMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0X9</accession>
    <name>A0AAE0J0X9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_553456</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676676.1">
        <property type="nucleotide sequence ID" value="XM_062829963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0X9"/>
    <dbReference type="GeneID" id="87867117"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3334510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="467" mass="52170" checksum="1B00503F9466BB4F" modified="2024-05-29" version="1">MTTATRMDFETTLKGKYPAKRHAQRVADYIRDKVPGASGVLYLEGRATKLLEDNDEAEPFRQRRYFYHLTGCPLADCHYMYDMDADKSTLFIPPIDPDSVIWSGLPVSVDEAKQRWDVDEVKYTSDVNATLAQVGSSKPKGSSVFAIPNQVSDKVTFLEFDNKNFSILKEAIEVTRVVKDEYELAIMAKANEISSEGHKAVMQKVKHVQNERELEAVFLGHCIAKGAGNQAYHSIVASGRAAATLHYVPNNADMAGKLNLLLDAGGEVDCYASDITRTFPINGKFTKESREIYDIVLKMQNDCIAALKEGVLWDDVHLLAHKIAIDGLTQIGILQGDKDEILESRTSVAFFPHGLGHYLGMDTHDTGGNPNYADKDSMFRYLRVRGRLPAGSVITVEPGIYFCNFIIEPFLKDPKHSKYINADVLDKYWDVGGVRIEDNLVITKDGTYNLTTAPKDPEEMEKIIQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0Z5</accession>
    <name>A0AAE0J0Z5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_480418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677099.1">
        <property type="nucleotide sequence ID" value="XM_062827573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0Z5"/>
    <dbReference type="GeneID" id="87864727"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3334933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="157" mass="17695" checksum="CF4D5EB44AFF9337" modified="2024-05-29" version="1">MPKNKGKGGKNRRRGKNENDNEKRELTFKEEGQEYAQVIKMLGNGRLEAMCFDGVKRLGLIRGKLRKKIWINNGDIILVSLREYQDEKGDVILKYSADEARSLKAYGELPDTAKINETDTFGPNEDGDCGFEFDEDRDSEDEEGAEAGGKTVDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J125</accession>
    <name>A0AAE0J125_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome recycling factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_480541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677144.1">
        <property type="nucleotide sequence ID" value="XM_062827587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J125"/>
    <dbReference type="GeneID" id="87864741"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="148"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3334978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="319" mass="35231" checksum="0374BC9573B24587" modified="2024-05-29" version="1">MKSFRAANALLRTNSAASNAISRAAPLVAASGPPACQCLLTPHATLSQSQLAVRPFSTTPIRPGKKDKKSKRGEEVEEQQPARGGGSSKKDKKSGKSSSGKDNTPAAAEESSNEPKDPNRPVPSAETPYDLSDLTYAFDRADKHYLDSLKTFRNGSRFSADSIGALPVFPDKKDTSLSYPLRDLATVAQVSGSGRKWSILCFDEASVKPIMSAVQKSPDFNQQPQRSEENPLELTITVEPERAEDLQKRVKELCQQWRDKLRAESHRREALHKKWKQQEAILEDDVKALKGKVQKMQDDRMKGVAAREKEVCNAVMARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J135</accession>
    <name>A0AAE0J135_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_592738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677157.1">
        <property type="nucleotide sequence ID" value="XM_062831131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J135"/>
    <dbReference type="GeneID" id="87868285"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3334991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="683" mass="74543" checksum="DE9A052E30AA2F67" modified="2024-05-29" version="1">MTPPHNVNHVSSAYNGAPDLTSKRSFYSHTSSCFEADDERSDTVSFFDWITTPMSGRMNPANDTFDNSPGDNSDYPYDDTDRDSSLPPARYPGDDTRPTSQKELAGWYAYAFAAEVYVICGIGSFIPILLESLARENGVLLSDRSKPCGSSSDKHATAAQGQCIVYVLGMEINTASFAMYTFSVSVLLQALLVVSISCAADHGNFRKKLLLAFAWIGSTCVMAYIFISKSTYLIGALLAIISNTAFGASFVLLNSFLPLLVRHHPEIDDIGDYGSPGYATTEDGDDEDDEYREDSMRNSTTALLGSRTYDEGEPLSRVQTTEELTSRELELSTQISAKGIGIGYIAGLFLQCVAIAILIVLKNTTWSQRIVLCVIGAWWAIFTIPAAMWLRPRPGPPLPTKSNTGGIRALFHYTIYAWKSLFRTIHLARRLVDIVLFLAGWFLLSDAIATTSSTAILFAKTQLHMEPWALGMINVISTASGIIGAFSWSFISRKFRLKAHQTILACIALFELIPLYGLMGYLPFVQAWGVGGLQQPWEMYPLAAIYGFVLGGLSGYCRSLYGELIPPGSEAAFYALYAITDKGSSVFGPAIVGAIIDASGEIRPAFWFLAAIVGTPALFIWFINVERGRTEGEALAEVIEGFKLNGLNELSGNGNGVDGLAEERRGSDASRAILGRYDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1M9</accession>
    <name>A0AAE0J1M9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain binding protein 11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_337004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677068.1">
        <property type="nucleotide sequence ID" value="XM_062823582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1M9"/>
    <dbReference type="GeneID" id="87860736"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="262" mass="29530" checksum="860CDEAC9F9FCFBC" modified="2024-05-29" version="1">MPKEKNYNPVQAQRKADKAKEIKKGKAQQQAKRNEQLARRNPEKIQQQIDDLKKIKEKEGKLTSHEEQVLEALEKDLKAVKKAREALGDKAPTFGHGPRRNGALGKRRREDEESSDSDVPQDVKRIPMPRDTPPPIPKDVLDEWYAKRRAKRAANANHEPVGEGRGHQQQQQGDQKTEKPKAPVVEVKTVYEAKPMVRDLKKEAVSAFVPTNVLLKLEKGKGKGGLMEPEEADELERAGYLKTSQSAGPRGVTMEEAEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1V7</accession>
    <name>A0AAE0J1V7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_543266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676822.1">
        <property type="nucleotide sequence ID" value="XM_062829223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1V7"/>
    <dbReference type="GeneID" id="87866377"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="248" mass="27752" checksum="D52F85B73045A04F" modified="2024-05-29" version="1">MATPTLISSLPDLQVFLSLIPPSSTFYLDLEGKSLSRNGTLTLLTILVLPTRATSIVDVQTLGDSAFTTPGTDGNTLKAILEDPHTSKCFWDVRNDADALWAHHKVRLAGVTDVQLLENGSRVGDKTYLYGLDRCVERDLGLKYVEKQRWVRTKQEVRALMNMPNNDIFSRRPLDAKTLQYCVNDVVYLPALHNLYAKRITKSSGWLGKAMDESARRVVEACGPGYVPQSEKKKFGPWGSGLSRNFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6M7</accession>
    <name>A0AAE0J6M7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_307769</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677382.1">
        <property type="nucleotide sequence ID" value="XM_062823243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6M7"/>
    <dbReference type="GeneID" id="87860397"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000725">
        <property type="entry name" value="DNA repair protein Nse1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000640">
        <property type="entry name" value="DNA repair protein Nse1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3337931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="332" mass="37357" checksum="63B4E612F480A07B" modified="2024-05-29" version="1">MEDEWEPPVPAGYNDANRAFIQSFMARGTLTFPEGQKLVAAILSATEGETVDPESITQDTFASFVRTAREAVEPLDYDIRSSRDQVRNGERIWAFINAHSDPATQMATTHTPEEVAYIKRLMDLLFDEYNTVRMEVMAVDEGQALKASRPSKRRESQHVNGEDEEGQPSTTASDRGLKHSEVLSLLSSLVAEGWLEKSRAGFYSLSPRALIEMWSWLVATYNDDSASAKDWQRIKFCESCKEIVTYGQRCSERDCTVRLHDICQDRYWRTRKGDKKCPKCETEWTGDHFVGERAITSRQGYQRGRGGCANGNGSGSGNSRRSDLEKAVAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7R7</accession>
    <name>A0AAE0J7R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_434780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677969.1">
        <property type="nucleotide sequence ID" value="XM_062825153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7R7"/>
    <dbReference type="GeneID" id="87862307"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000096">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110233" checksum="5070F07A213075CF" modified="2024-05-29" version="1">MVVKVDYDRDYYADLELPSTADTAEVKKQFKKLALKYHPDRNPGKEEEAKDRFIHIQAAHEVLTDPSNKAKYDAYRKRGGAATSRYSTASGHRGNPYSNVSADMADRYGAPPTRRTPHMPSRADPGPSAHARYSSWGTGTPSSSSSSRPVPPKTASAADNLRAWDAMRSSTKTGQTSSSTPKSSGYASARTERTERTESARREPPPVPPRTAGQARRADAAFGTTRRAGYSPDSPVGDEPSVSRHNYTSSAHYTATTNMFEDTAANIRKSRPQSSPTPVDPLSEKFSETYLDSRQRTPYASHIGEKFNPFEGANVNRAKSMKDPSRPTEESEEEVPPPRPSRQRSASVGESNSFGKAANGGTTSSGTSKAEPRASARYYAQEAEPRSAPNTAANPTPRASSSSMRSNPNAQPGTSESAQEGPKVYAPSPFFKPDEYFKSTSSFGQPSKIRPPHVFSHAGAGSYRGRAHEDTANNRKSHGRETPSGDQSTSGDMSSFEKDMHDQLQLLLGRRKMHSRRQHIKPTDNPLSPRKTNVHNRVQKQRATNSVYPNSFTVPDDDGYTQKQQASGDFTRSGVHNINASFVDQEKVGAGFQFNAGGSTTIPGADAFSRAKQRARSVPRGRQSPLKKTYTSSNESVSGATRPPSETNDAGKKPSAFDAGQWQAEFGPHTFVPPPTAKKSSTSPTRNVRPIRKPRPVKMTAGTAGLVDEEETSSSDGKSRSNSAAGVDESNINGAPSPMAMDIDDPPPPPTPAHAVPPAAPPPTPAHGIPTHLNVNGASARNVNLEPSKPEWRAGSLNNGVKTSNGTSSRRSSSAANTTHRPIPVANAGSEDSDLRPIFGNFDVDKLVNPGTGLNSFSADLKSNLPFESRASAKLPPFEREKIKPKNINFPTPPKAPSPPAALATPSQMTASQWVLYAEQFKLYIHQFNTFNARVVDHFAARKIKNEQKGAAWVTQLGDKELLEYLAWMEEDKTVMQKWAQAREAHELNVMEFARWKERVRSGGGAASVTAGDGTGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7U8</accession>
    <name>A0AAE0J7U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 19">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="4 19">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_446344</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="19">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="4 19"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677949.1">
        <property type="nucleotide sequence ID" value="XM_062825794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7U8"/>
    <dbReference type="GeneID" id="87862948"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
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        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="10 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3338498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="364" mass="41811" checksum="F61A3F806BF58BEE" modified="2024-05-29" version="1">MAEFIRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSAKDQLTNQNVAIKKIMKPFSTPVLAKRTYRELKLLKHLRHENVGLPDSIVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPKRERQPLKNKFKNADPSAVDLLERMLVFDPKKRITATEALSHEYLAPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVEASGQMEFSDELVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8D4</accession>
    <name>A0AAE0J8D4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prp 4 CRoW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_323069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677878.1">
        <property type="nucleotide sequence ID" value="XM_062823431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8D4"/>
    <dbReference type="GeneID" id="87860585"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042098321" description="Prp 4 CRoW domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="27543" checksum="32B12D77D3DE5DEE" modified="2024-05-29" version="1">MLVKSFTALAALALAAQAVAEPIRIGTPYKANKVHKTSVRQLFGVVRRQDNPGYQPEQTVCGTGNTCSEACGAGFETCASKDDSVHCYNAGAAQICCPNDSGSSCDAGYYCAADNQQETWCCPDGMGLEECAKAYGVDSGLVSQTAEATSTSTTSTSSTSSVASSTSTSSTVVSTTSSSSVVVTTTSSVVVIPLSTSSAALTTSSAPAITIPVLSSSSIVLVPTGLMPTGGAPSGANGTSVVVVSPQPTQSEVAIGAGSVAKPAGAFLLVAAGLAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8R5</accession>
    <name>A0AAE0J8R5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_582163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677782.1">
        <property type="nucleotide sequence ID" value="XM_062830842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8R5"/>
    <dbReference type="GeneID" id="87867996"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="976" mass="105220" checksum="171DA3B4CCBA896A" modified="2024-05-29" version="1">MASHSHHNHPSSHSCQPPPLGLDGATPWPGPIYRQPPATACPPPPSQIWPPTSIPCEDRDAASVKSSGSSSSRGGRKNIIAASVKGFFHSLRPSNCPEQGFTLRRHHDHHSHGHQTIDEILTGESRHYTPSTPDTIVSEAWNIPVALPRRASGVSGKSRVQSTPIPVRKIKSRLDTRSDDGPNATHHRGEDAISSLDGTWANMRERRVKSGNIPTFSMPSRKPVPIQNRSSLPIPSQANVGTAKSHNIMPSVMPAYNKARSLFLAKQEARRQRRILREAGDYLGVTGANPYTGMLDNITPRTSIDMTEFRRGFPQSSPQNEKKGRGTGKQTSPRRRSKLGKEAEQWSSAASPNLSPIVQSQSPSNKSAEPAQAGQDGDNGGYGTVRRRPGFSDLIPVESEVSQATFPSIDSPAAGSRPDGHRPRPGPDWDKEALLQDPSARWPPSFAQDVARNPHDTRSQQRRGHLPTFGPREPEPSPPMGEHADGGSGWPGAQHPGQHQRSQGMGEFRSPGHQWTGTGAPPPTTPICLHTHHHHYWLRVQSSPSAPLRHKGNLPRRTRSQGPSKGKKDVGDESSQEGSEDDRIRNRIVVTPDIVPVAERHTQERLFDAAGFPSQQATERLAETRKTRSPSSSQLDGITDGRPSCRDGGRRCGTSFPGRVTKSSQRYYIVNPRDNAHGGLGENLPARVDASSSETAGSGDAQDDEKGSGNPRRNKRKETVTTQSKSWSAHQGPADIKAFTQAMAQGAARAAFVQHAADQRAGPEGIPATGRTITGDTKVGVESTAAAKSAMEAELGTGPVTSLAEQMNKRHKLKDSAGHGSGDIDGRSRSQEAMSEQASEPQTCQGDGAAASDDLYRLFPGLALPVRYLMVAAGSGGQGFEVPVGVRIVVSVVATFVAQFVCAYWAFVRPVFHLDSPLHKRYARGQATLGDVVVYIFALMFVFFAGAAVVWMIRGTVLVCRLARAIIGGLAMLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J920</accession>
    <name>A0AAE0J920_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_579791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678271.1">
        <property type="nucleotide sequence ID" value="XM_062830780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J920"/>
    <dbReference type="GeneID" id="87867934"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="73103" checksum="CE034303C6F2E23C" modified="2024-05-29" version="1">MRRTRGQQAAAAAATAAVAQTSNGKGEKAARSKPSTTVATNNAPVIDLTVVSSPRHSQDALLGIDLGSSGIRACLMPPNAPEKLLMIHNSVYGNDSFTFPANGRVFGPVRPAEIYLSKVDHDGHEVVALKYAFYILAGASDTLTGEYPLIDKLKAEAIRKPKEFRARLRLGLLQMFRYVILKVHDSIAAGRHPWRIGKACITIPSQWDLDFEAQYSAILGEALNWSQDYARDRMMFFYEPEGLAHFLLHTQLYMNDAIAKSQAHEHRPCLVLDFGGHSMNGCLYYINSKRGDTLNFYAMEDAFGVGSGGEQFADRLVKACDEVWLKTSRTPLRPEAKVQIRETIKKYFAYWGPGKTTGEQKFFFCDDNDDSGVIRLSEEAIDECWAGAYKPALDLVENKVEYLKQAYKSGKFENKPLVVAAGGSLLNEALNEAVEAMVKAAGLGPILKVTKQGVSHDAQRNIVGILHSVAKALTVLQFLRQGAGIAMQMRQAQADDWDDRGAPFWYYWVEGKQEIRPQCKIRVQAGDRFRLIMNPFYGQDVKRFGKLPQIFVARAYNFLRKFPIMPRSGLVECFVQWVGEGNEVVMHLEIVLTPEEEEEEEDTDSRIRWRYKLPLFFDCGTRCMMPGKRSTRLEDVVPDLFTDADGDTSMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J941</accession>
    <name>A0AAE0J941_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_579788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678268.1">
        <property type="nucleotide sequence ID" value="XM_062830779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J941"/>
    <dbReference type="GeneID" id="87867933"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="620" mass="70731" checksum="F31E0B66264CF7CD" modified="2024-05-29" version="1">MDNPGDMVDKWKELYPTQFLAIHLGTWKSRVMVVCPPTRLEKLHLMQFIHYPLHHPHRGSLQQTYDDYYGRKDWPSHGYPLDDDGPDYDADDRGQHQSCQPVPLRYGFYLLAKEYGKASIQHPIAQDLAFYDCPELRRKLYSGLVTMLRMIREVSENDPTSEGLNADRELGNICLTIPAQWDSSFQKVYLDALAAAFDYQPETLREKVMFITEPDALVHVIYGCLTHKPTPMNRQPQIELFLNFGTHTTVCSTPANIILLTVLTRSYSSQDGSMFWVGPQEVNGPTTVRTRFFRMGDPFDDSFFSREGRPLSARERLHITSKLKLSGARKWGPNYRSQGTCFSILTDGPAYKTVEISISDQEIRHCWESAYRPSLRVVAQQFALFKKIRTETSAPGLVYVTGQDLWRSRPLEAELENLARQAGITNFQIEESCAVFGAIRAAEMKLTVEQFIIQGVGIGLQKKLPGTSQWEDDAALLCYYDINTKEYQRSRSTSAQPQVEGTQFRLLCNPLYHVIPPKNSQSEKPPNKAMKTPIKSYQSYVLFEDMPTVQQRGKYVCHVAFEGSGDEMFLLVNVEQGRPSTTKTAELRLRLRYNPVPRRAEAFLEPAEGDGEDEDMEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9A1</accession>
    <name>A0AAE0J9A1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_445252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678373.1">
        <property type="nucleotide sequence ID" value="XM_062825732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862886"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1494"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1582"/>
            <end position="1801"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1819"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="2205"/>
            <end position="2831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="159"/>
            <end position="193"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="225"/>
            <end position="254"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="2507"/>
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            <begin position="2529"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="2595"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="2692"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2831" mass="318586" checksum="9A1989A6056E7608" modified="2024-05-29" version="1">MSRRSRLPSSLYAPQEEDLGWSSYTPRDPTAAAQRAQKSQPSRSNLPRPVSSSIPRPAATISRPDPKRLDKDDGSYPDSSPWPWLDPDEDDNFRQVGKKSKQKKKAGGGGGGGAQQPKQTNNDGGEGSQKEGADDGDDGKSNGGDASNGPGGGPGKSGNDGDKGDGDKKDDKLKKEAVDDDDKKNDDEEKKAENANQSPLDEDWNQATSKIRQKAKRGDVIGSVTEDKPTPRSLDDKAKSHGNSDKSNGLDEVKLNTATSINANRVSTDNASIDNRSSGNSRIEETKSSGERTLSDSKPAGFPWSALWGGGLKWGASSHKEQPKTQVKHEDELESNPWSKSKNTKTFPGSFDAAEETKEEPAVTEPKSEKKRDLDEKGQDRDEKARRQKDTKDDKDDKQNGINEKYSANEKKQDKDDEKYRVDNMYAKGVKKDERKDDHDDGFVVSTKKSKKSKNNTSAWDVEPDAWQEPGVEPKIEPKPELTKTTELEPEDDFFESFPAVKKNEKSSTRLGQSSSRLAPFAPTLKKANPDPWEVFGAKKNKARVGAAEEPMVRTRKADPELLPATRSSPIPEPEPEIEPEDDEKLEPILPYKPPTKKAWWDEPPAPPSPVKNKKKKGKYDVADEPPRDPDPEPKPIEESKVETDLPVEEDDFWGNYSKTVKKDKRKSKRAGLSEEPAPPPPPPPPPPPPPPPPVEPAETFPWDDVPIKKTKKGRRGQTEPEPPPPPPVELEPVAEPDPEPEPVSGPPQFPESDEEDEHPGGWFSSFLHKTDKKKIRQTSPMPPPLEEPEPEPEPVQPEPEPEPEKEEDDPWDYPISKKDKRKKKGKTSEPEPPPPPPPPEPPKRSKSSKYDKEDEYDFWSGSTSKKNKRDKKGHAERVSSPEPYVPEPVEEVISELEDPEPEFDAEPEPEAQPEPAAVSDREDRLSDDGWGYSKRDKDKKKKKGIEPEVKSKKESRSSRKTEPEPEPDSKRKKAKDSIWSLPSDPKKDKKKRRGDLDEDSKPLASPAPDPPDVWDDDYQDKKKKSAISDEWANYSNKDKKKGKNAMDVLMGLNKSGDPLADSARQSPPSPPHRTGGFFGSWETDSDRDDNRRHRKRSKDSSQKPYSIEEPTLDDVWGATMPGKRKKKANAGTDNEPVEIVEDLTPDPIQPDSVEETRDDRYNQEDSKPESNSYGSSFWGWGGFAKSSSKSSNKESSLHDEPAPPPPPPPAPTPPLDEPELDIWADDDDEPQPVVKAEKEDKKKSKDKKSKDKEPKLSEKELKKLEKEKKKAEKEEARRRLKEAKELEEELKRNAREAKELDEALRRKAERERELEEQAQREAEEQAAREEEEQRLREEEEQRQREEEERRLQEEEECRQREAEEQARIAEEEARIAAEEQARREEEKKVAKEKEKLDEEAAELETLRLKKEKTPRRFTTREQRRLDILASKFEEIARKRQEEEEERQRAEEEAARIAEEEARIAAEEQARKDEEERIAREIAELEEEEAELQALRFKKANSPRRFTTKDQQRLQQIIKQRRERKRLKQEEEERKQREEEEERQRQADEEARLAAEEQARKDEEARLAEEARIAEEEARIAKEEAQLAKDEAELETLTNKKAKTPRRFTLMDGRRLDVVTKDVNRRREEKAAREAAKKAAEEVPPEAADQPGDEWQDADEGQGANNDEDPEAAALREATERAIRQAEEEAEAKQARKASRTKGKSKADPLDDIQLTPEQVDELLGESSKRDKSVDSQPKEDKPDNNNHNNAAPGGFSLWGAAKRGIFGFGGGGGWEDHNEQPAPEPEPSAEDDKAAESSRMVEAAMAAGGVIGGVPPGLWDATPKAVSPSPEPTAEPVVYPAKPTKSKKAAGSKSKSKIADRLRVFESLDAGADTPADADGGPPAAPSTPPPHFGRPPPPPAPYMVRSPPSPAISPVVAVAVSPPAQREERRKSSRKSRDKDNHDYYLSVPPPSPPPVAPSGAPPGGFPGGFPTDNDYRPSRDMHGDHHDNDPDNHREPELVDSAAERAAERRAKRRSKRISPEGVEFDLPPAPPSPPPLAPDAPIDDEMAESKSPRKERPKINRQGTAWGMDGKKPSSRPKVEREPSAKRKTAHIETPEKPPRSRDKEAPAPTAPAPMQARFASVFTSTPPLSRSMSQREKRLGPNGKPIARRYSDSTNAVATPPAPAPPPDDISSKAAKVLGVGARGLGVGLGLANGILPNGFGRGAPAAPARNKQDLNDNTPVSGAIDPDFSPTKSERRRAKVCDSPTFAASQSNQSVANNKSQQQYMSEDDHVMFEMPDAAPPARPPVRRVSTSNANKKPGFSLFGVFGSKQQQEPPPRPEPPRRSRTVPTYQTTDDEGGRQPAAAFVPETDADREARRAARRARRAEKEAAERGAAVHSAEEARRQKDEARRERRRKQEEEEEARRLEEKEARRAERRARKAREEEDRRAREEEERRAEDQREAERAERRRIRAERAAAEADAGHRDVNGGRQDERHRSSRRMPPESDREHDRDREDDEERRRRREARRAAKAAQLAAEAAADEMDRARRERRPREKSTARPEPRDAPPDEYVYPTSRQQSKARKHGQGQHDGWPHSGTTSWVKDHADAPAPPSPPRPPGTFVDDHANGHANGGAPPPPPPVMRHELDEEEAARHARRERRARREQKYHAAQAAAEEAEREREREREREGAYVSAHDDERRRRRRRRGDEERPERAERERERERDHPREQDHRDRDPRDRPERSQREQDQREYYSARDDREQLPRPRERKRGERAADYDDRDPRDPREYRDSRAERGERGDHGGDRTGSGSGSDGRENRKSGGGAGFGDQSTTPRSSWWKKIARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9C7</accession>
    <name>A0AAE0J9C7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit GAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">H/ACA ribonucleoprotein complex subunit gar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">snoRNP protein GAR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_511327</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678418.1">
        <property type="nucleotide sequence ID" value="XM_062828476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9C7"/>
    <dbReference type="GeneID" id="87865630"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042265840" description="H/ACA ribonucleoprotein complex subunit GAR1" evidence="14">
        <location>
            <begin position="27"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="15">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3339058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="484" mass="50086" checksum="BFA7A5F0DDE8B7CC" modified="2024-05-29" version="1">MLSRNTQDMVLLTIAYFLASITSVFAECTREGLLAAANSYVSAFSAGKLDGLKLDSSNFTYQENNKAADIKRGVLSQSHNISLNRSTADTVACASYTMIISLGSGSNSKPYVTATQIRHPADGDTSVISSIDTIAATAGSLFFNAQKTLGYIQKENWGVIDTAANRPSRELLRKVGDAYLDMWTDAKAADSIPWGTDCERVEGSQYTRPCGGQLPRGGSSKRNGNRRYVIDEVMGSVDVLCSFDALGNMPDSHEIRVEGGKVKGRGGGGDRGGRGGFRGGRGGFGQRDDGPPAQVLELGTFEHAVEGEMFYKSTNPKIPHFNAQVFLENKTPIGKIDEVLGPLNQVYFTVKPQTGIVATSFKPGDKVFVGSEKLLPLERFLPKPKVLGAPKVKKAGRGGAGGGRGGPRGGARGGGRGGFSSRGGGGGFSRGGGGGFSRGGGGGFSRGGGRGGSGGFSRGGGGGGFSRGGGGGFSRGGGRGRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9E6</accession>
    <name>A0AAE0J9E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_542148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678774.1">
        <property type="nucleotide sequence ID" value="XM_062829199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9E6"/>
    <dbReference type="GeneID" id="87866353"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="250"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="673" mass="75608" checksum="CF57CC9FFC810059" modified="2024-05-29" version="1">MDGKPLEESSSEDDGSTRQSKHILESSDMEPNRLCKRCSRALTASKTLWQPRPAGDPDWAGERFFHSKNTKQMLRDLVIAAGCHLCTQVSQEHNFSRAGDDQRVMVECSRSRAFEADEGNIPIVLFSAISCAEWDDNWASLPDPFKDEEPQPQGDSDMTPLAKFKLERTDDGSMFVLPSSTNSPEAFGLVRHWLDDCLNNHPECKGSNFKRLPTRLVDVGAPDNNAQKKPPRPRIFIPNATSQTPATIPYLTLSHSWALTGSSLRLTTKNIEDWQKPEGAEHGGIPIDGLAQTFLDAMRITQQLGYRYIWIDSLCIMQDSSEDWKREAQTMAAVYGNSLLTIFASGMGMAGGQGANADTCFSVRNPLKVYSPIITSPLSGRASFYAIREKYEPNVDEMLWGANQKNPLLSRGWIVQERLLSPRIIYYGADELYWECRLHAVSESCPFGTGLKKDAEASQSIWTANAKAVYQDLQDPFPASLKTGMDMGNDKEDAKYAQHLQLIALAGMVTAIEESKGWTYTLGSWQELWPFDLLWGFDSVLNVELFNPGWYPDDSEKRRQDRDEMARKLLKGQSYPESHASTTLGLPSWSWAATEAPKSFWFGSSGSLTWKCQIDVFGRTTTGMQESGILALKTYKKQLYDMPPIDLGLMWDDDESFYSKDEEVLAGRVYLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9W5</accession>
    <name>A0AAE0J9W5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_577589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679030.1">
        <property type="nucleotide sequence ID" value="XM_062830698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9W5"/>
    <dbReference type="GeneID" id="87867852"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="277" mass="31029" checksum="F2B557D1253504FC" modified="2024-05-29" version="1">MDYAKHPEKDSINSPGGRRENSSQARNIRLPTTLTPAHSTKKSTTATIWFKLLRIAPQDRPLVTPPSYPGEDVFYTLSIGKSLDFKVETEPVVPKNWQDFGYQRQHTTRNTKPNNPRQTSPSLPPSTTPSASRIPLPGRLPFPTRTNKYFPVNAQLPTKMTWLDVLSLAQSVLACEEESAINQVHVRTVGEVDEDPAADADGHSLLVKSHVAEVEECVDDDAEEEDEDTGSVIRSSFSSFDIRDVNLSLHKEVSRIWSWREKWRGTRGGVGRTGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAM9</accession>
    <name>A0AAE0JAM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_578063</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679380.1">
        <property type="nucleotide sequence ID" value="XM_062830718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAM9"/>
    <dbReference type="GeneID" id="87867872"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3340438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="105" mass="11370" checksum="4F839AE6202171E9" modified="2024-05-29" version="1">MSSAVAIGAGVAVAAFLGRAGLVAWRRSRGGVGALGKAFYKGGFEPRMNKKEASLILSLNERTMTKDKIRKAHRNLMLLNHPDRGGSPYLATKVNEAKEFLEKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB96</accession>
    <name>A0AAE0JB96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_408902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679755.1">
        <property type="nucleotide sequence ID" value="XM_062823824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB96"/>
    <dbReference type="GeneID" id="87860978"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="45577" checksum="F125D946719E8721" modified="2024-05-29" version="1" fragment="single">MSLSRPNVFRVSGIPANSDAENSIQQDAEAFLFEFIQDKFQDHERGQIEPDIQIIPSCTVSSNTVNALVEFSPTEPEFLKEVLNNRESNLRTLKRVNGKRIIIYFDLHFAGLTQLYPTPPDQSVTVDIIAITGLGGHSYGSWRSRTGPEMWLRDFLFEDMPRCRTMTYGYSSQLLKRGVEKVEDYRRHFLEEIIIARDSEGLRQRPIVFICYSFGGIILAEALVHAKLTRDTNPDMEALSKATYGIFFLGVPHRGLWVDDMLDMLRAIHPNHPREELVKQLQVDSPSLKTQLDRFRNLCHDYELVSFYELGPTRELERDVASGRFGRSGQFRTAVTSESAMLQLPDSKEKKFGFPADHSDIAKFSERYSGPYKIAIRYLNIFEKDSQEVVRRRFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBA4</accession>
    <name>A0AAE0JBA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_274155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679814.1">
        <property type="nucleotide sequence ID" value="XM_062822788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBA4"/>
    <dbReference type="GeneID" id="87859942"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="358" mass="39742" checksum="0E22A0ACC68ECFB6" modified="2024-05-29" version="1">MDNRSSDVSPEAMQARIQQARREAENLKDKIRLKKEGLADTSLYEVAQQAHEPLPKNNMMRTKKTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYNLNSNRDGPTRVYRELSGHAGYLSCCRFINDRSILTSSGDMTCMKWDIETGTKVVEFADHLGDVMSISLNPTNQNTFVSGACDSFAKLWDIRAGKAVQTFAGHESDINAIQFFPDGHSFVTGSDDATCRLFDIRADRELNCYRSESILCGITSVATSVSGRLLFAGYDDFECKVWDLTRAEKVGSLVGHENRVSCLGVSNDGISLCTGSWDSLLKVWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBM2</accession>
    <name>A0AAE0JBM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_530258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680009.1">
        <property type="nucleotide sequence ID" value="XM_062828924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBM2"/>
    <dbReference type="GeneID" id="87866078"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3341067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="270" mass="31134" checksum="EBEAAE1A8CD27725" modified="2024-05-29" version="1">MIPQRPHPRRTAPSGVPFPRRTLRCQDAQIRLPEDSIHEAGRSPVALHVEFHEDEESDSPPRGQGTSRGVYGSQPPIPLQGDEPSLPTRQESDEDRLIRRNIEVFRRRLRAGLLAPVYHHSQQTRRRPLLFQDMEQPSRQSRRHPRTHLIPLPSAPQADPFRPPPSYSPRNPRLHPTGEDYDLTSSLYHRLHNNGAPPLPVYTPVAGPSERVLQFGGSEYEQRNALLRLLQERNRQEREREEAMEEIRLLTWEEVKSHMESGLAIYGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCG0</accession>
    <name>A0AAE0JCG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TORC1 subunit TCO89</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_429386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        </source>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680589.1">
        <property type="nucleotide sequence ID" value="XM_062822170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD09"/>
    <dbReference type="GeneID" id="87859324"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000170">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000182">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF301">
        <property type="entry name" value="POTASSIUM CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="211"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="370"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3342796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="748" mass="84389" checksum="C471A8D3AD668FFA" modified="2024-05-29" version="1">MEDAGGDNVEEPLQEVDEQYKASLPKRMGEDQAHRDPSRWWFASAAFPMVAGTLGPVASAFSICALVRPWRQNYTKGADIDTATFIKDPAWLIAINAIQLAIALTSNLALLLNMTRRLRFSIAQPVTIVGWYLSSICLIALASTTAGPLRPENNDFIWSQAYFYGIYAAVLYFVVASLMVVTVWASQKGHYEKDFMLTPSQRTLMLQTISFLIYLLIGALIFSNTEGWNYLDGVYWAAVTLFTVGFGDQNPTSTLGRGLLFPYSLVGIISLGLVIGSIRSLMLERGKRRLDARMVEKLRHRVLRKMAKKGKDGILTPIRNANSDSPELSSSSGLTEFERRQSEFELMRKIQKQAAHRHRWIAMAISTSTWLVLWLVGAKIFMECERQYQQWTYFDAFYMSYVSLTTIGYGDITPISNAGKSFWVFWALLALPTMTVLISNAGDTIVKGIKDATDKVATVTILPSERGFKGEFKAAFNALSHGKLFTEDIEESPPGILGVSQRHRYSSEEDDDEGELARDQADLDAEGANTGPRKQKQAKNARDEESHKRRVEGNAAEEDSGDRPDRTVRFDDSSTTSGKKGSNGRSKKMGNTDDEENPYDKNSNSTSQLPRMTRAVSIPRQDLPQTPTDPAEYHLTLIEEIGRVTQHLKSHPPRKYTFQEWAWYLRLIGEDESDAAKHRKPYTHLRRSKDELEGKERGRWSWVGSRSPLMSSQEEAEWILERLIETLDDELRGVKAARRKDGMKNRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD79</accession>
    <name>A0AAE0JD79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mpp10 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_469729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680709.1">
        <property type="nucleotide sequence ID" value="XM_062827027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD79"/>
    <dbReference type="GeneID" id="87864181"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="685"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3342916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="785" mass="86539" checksum="40A64AB48E0232EE" modified="2024-05-29" version="1">MAGAGSITSSVTSTSQTITHDPSTHNSVMAATLAALSSGTSSRTIDSNPVVASFLSALADESNRHVFLQPPSTLPAGSLLLAKETLDALASQVSDHQQAKLKEIAATIGGKKRKREAGYDKNAVLKIRKLHVDEGFETEQIWQQAKKIIASAVKEAGDVLKELEENGIVGTGEEQEKTIEFGEDEFELGSDEEDGDDESGSGSEGEDDEEDDEELEGEEGSEIDDDEEVEIDGEEVEFSDEDGEGEFDEEDEEEEDEEEEEEEDAPELVEDPNGLNDGFFSIDDFNRQTQLWEDADARADPNVDADSDDEQLDWHSDPFATKPKSKKGKSDKKKDENEDEEDVDMGDESEDDEALEAAAAAHAKKLKGKKNVEQLEDDGDDLGLTDGVLGMDMDLTANDVYYKDFFAPPQKKKTGNQRKGGYFPKKKLEQPDEADMERAENDVRRDLFDDLSENEDDEDKLSDLDAGDPRSRRSAHERRQAKIAEEIRRLESELVAKRAWTLSGEASAQARPMNSLLEEDLEFEHVGKPVPVITEEVSETIEALIKRRILANEFDEVLRRRPDTLGNPNNARRGLVEIDDAKGKQSLAEIYEEEHVKEANPDEYVSASDEKLTRDEAEIKNMWKDICAKLDALSSWHYKPKPAAPTISVVTDVATVAMEDAMPTTAQGVSGGESTLAPQEVYAPGKDSAEKGEVVAKSGLPIAKEEMSREEKARRRRREKERIRKAGGLDANKNISKGAQERKETMSQLKKGGVKVINRKGETVGLDGKKIAEQKGPTSSGAFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDD8</accession>
    <name>A0AAE0JDD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_228540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680531.1">
        <property type="nucleotide sequence ID" value="XM_062822149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDD8"/>
    <dbReference type="GeneID" id="87859303"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="111" mass="12797" checksum="AE2B47CB7F34F4E0" modified="2024-05-29" version="1">MSFHITAQEARIEQRDGHTYLLARLQREDGSWNDAIFNLDQIIGNEDGHFQWGGQNFTHSAQDIRFDPKEGAAEQPILRAMLCDRNGDYYPRDVNLTEIIENVNGEFAPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDJ1</accession>
    <name>A0AAE0JDJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_243026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680980.1">
        <property type="nucleotide sequence ID" value="XM_062822349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDJ1"/>
    <dbReference type="GeneID" id="87859503"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF8">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3343187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="549" mass="62156" checksum="D4C1806A16E537F2" modified="2024-05-29" version="1">MSLGNSIVQRALITYHDLSMATKAALAISIALVLYRFLFRHESTRRKELPAWGPIEMGLVMYLLDGAHNSMVYRIYSTIRRYGGSFYGISSANQTLIGYEDVDRLFSSQMNHALSIEWHGYGLFLRFFGFPDTPALRKKVESTFKPWHSPIERVFNNDAGATAAFERGNLPKMVSEFVSFSQEKEKMKRWELRADTKVIKQGEAVEANFSALIMDFGACFTIPPIFGHDLLDRNPHLLEDIWKFDHVVPLLFINMPKWVPFKVMKEGLKARKRLLDGVEAFSRRVTQFQRGEKVDDAAEMSDVSDVVLERNTALKRNEWSYKERAASELLVLFASNTNTQPVLFWLVLYIYSTSGLVDTLRKEVAPFVTLSNSHNKKEITAIDTSGMSRECQLLKSIILETLRLAFGAVSTRFVKRPITVQDGNHTHQLHPGTFLSVAHSFSQRDPSLYPDPDKFVPDRFLETDPSSGKLVAKYGKLRPWGAGASMCRGRLFAEKELMAIGAALVMLWDISPAGGCEWRLPEMVGGPGPVKPKEDVRVVIQRRVFVSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDK4</accession>
    <name>A0AAE0JDK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catenin-beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_243670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680995.1">
        <property type="nucleotide sequence ID" value="XM_062822358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDK4"/>
    <dbReference type="GeneID" id="87859512"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000354">
        <property type="entry name" value="DUF1716 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3343202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="616" mass="68330" checksum="8D292635F74862B7" modified="2024-05-29" version="1">MNVDELFQKAGVPSKRKLDPIRDPNEIYKSAKLSSNGSRHAQVEDEDDAEAGPAPPPEDGEDDGDYGPSAPLIEDDGDDEEGRFFGGGITAQEKEILDFMDSNTAAPADDLLTTDKIDLSWLKKTALNFEKRITRNAELRARHEDDPSKFIDSEADLDASVKALSILSEHPDLYADFARLGCVSSLVSLLAHENTDIAIDAVEIINELTDEDVAASDEQFSSLTDSLLEADLLGLLVSNFSRLDEQHEADRTGVYHALSIIENLCSRRETADQIGKHTELLEWLLSRAKKSEAPTVSQNKQYAAEILAILVQSSPANRRRLASDELNAVDTLLTLIAPYRRRDPERGSFEEEYMENLFECLTCLVDEQLGKTKFVEAEGVELCLLILSSSDVKGKLSKPACLRLLDHAASFSGEVCLKIVEAGGLKTLFTLFMSGDKEKDKKKGKATRISKQDTEHLLGILASMLRHLPASSPTTTDETTGAERIRLLAKFVEKDYAKTSKLIRLRREYAARVNQVDEAIKAEAASNPEDFDEDEAFSRRLDAGLFCLQTIDVILAWLIAEDDGCRAKIRELLKDRDEDFGVLAKTLREQRDGVDGETEEGRDTGEMLKALLEFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE29</accession>
    <name>A0AAE0JE29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_548357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681174.1">
        <property type="nucleotide sequence ID" value="XM_062829574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE29"/>
    <dbReference type="GeneID" id="87866728"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="180" mass="20514" checksum="E9F092DF0F66F575" modified="2024-05-29" version="1">MSEPRQTAMSPSPEAKLDPNPGTESDQAGQAPAPPGPSLGPEASVSKPEEKEESRLSKVRRDAEENYNALTGLFLISQAILARPNREHLPRELINAMRDDHLLQIKYREVWLKSIELQRRNEEFDKDLAKLGERRVELIKDMRELKKKKQALNIESDGIRDRFAALGTVGNVNFSERFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEJ3</accession>
    <name>A0AAE0JEJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_246049</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062822398.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Acyl carrier protein"/>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_carrier"/>
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    </dbReference>
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        <property type="entry name" value="ACP"/>
    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
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        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3343338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="137" mass="14642" checksum="92BC6E95848BE56D" modified="2024-05-29" version="1">MFRTAALTAARVARPAVASAVRVAGVARPAGAFVAAVPKVAAFQAVRFYSAGGHLKKEEVFSRIAQVLSGFDKVNDPKNITETAHFANDLGLDSLDTVEVVMAIEEEFSIEIPDKDADQIHSVDKAVEYILSQPDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JES5</accession>
    <name>A0AAE0JES5_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_442161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825564.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87862718"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="38"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="104" mass="11247" checksum="1518E4B4802B34CF" modified="2024-05-29" version="1">MTPLTCSAVGGGKAGFVWVTLGPSLLGLLLGLGAFEWLPYHVGFEMGYVSLTQARERWNRSVTSSGPSNLPHHLHQRSQRKSPSRLVSSATLGGDDSFRAFWCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEU9</accession>
    <name>A0AAE0JEU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_427010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681388.1">
        <property type="nucleotide sequence ID" value="XM_062824659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEU9"/>
    <dbReference type="GeneID" id="87861813"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="63" mass="6801" checksum="94FC2AB987F65C16" modified="2024-05-29" version="1">MPNNNLSSAKAQPWKKGWIARNSLGVKKQPPKGTTHGTKEGERLIQGGHTFGIPIKIVPAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFA0</accession>
    <name>A0AAE0JFA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">VTC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_199769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681834.1">
        <property type="nucleotide sequence ID" value="XM_062821765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFA0"/>
    <dbReference type="GeneID" id="87858919"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07892">
        <property type="entry name" value="PolyPPase_VTC2-3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="55"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3345221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="800" mass="91918" checksum="54533FCFC41A527B" modified="2024-05-29" version="1">MRFGKTLKQSIYEPWRDKYIEYDKLKSLLREDRPDDDDEPWTEEDEVRFCDEIFNVQLEKVAQFQEEKMQELRQRVDAAFEKLRDLPPADSQNKDKPTDEALAQQLKELEAELDGITNEVKELQKYSNINYTGFLKIVKKHDRKRGDRYKIRPIMQVSLSKRPFNSEQGYSPLLNKLSLMYFAIRQHLEENAPAEPYHLDPVSQPETHNGEKYTAYKFWVHPDNLLEVKTFILRRLPTLVYSHQSAKEWDGDEDPTITSLYFDNANFQMYYQKVEREAEASSLRLRWYGQLSQKPEIVFEQKIIHDNGTSEERKFPIKEKYIKPFLDGEYKMEKSIQKMERQGQSTADVEEFRSTAEAIQDYIRSNKLEPVVRANYARTAFQNPGDDRIRMSIDTNIAFIREDTLDRDRPCRDPQNWHRTDIDDSNMTYPFKNINQSEVSRFPYAVLEIKLKEDQNRKRPVWVTDLMASHLVHPCPRFSKFLQGVASLFEDYVNRLPFWLPDLDTDIRKDPQVAFEEEEAKRAHRAQNEQVVGSFLGTKLGNSFKPSRSSPMAKSYLAERVAAESSGAKAQTPASGTDRTPTGATPAGELNGSTSGQQQDGGQQQGGRSDYGTMTLSSVFPGFSLSKYSIAMRLKRAQHEGGRRGSVTLPPGVEEPTEWLKNSGPLQIEPKVWLANERTFLKWQHICVLLGGLAISLYTAAGRDTVAEYIAVGFILVAAFAGGWGYFLLHSRRKMIMERSGKDFDNFFGPLVISAALMVALILNFSFAYRDFLARTRAGTKVEALFIQSSSSSASPVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFD2</accession>
    <name>A0AAE0JFD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0H65DRAFT_202649</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681927.1">
        <property type="nucleotide sequence ID" value="XM_062821813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFD2"/>
    <dbReference type="GeneID" id="87858967"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="756"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="757"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3345314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="806" mass="92991" checksum="DBA85E96EE788316" modified="2024-05-29" version="1">MEFNIDDLPVLFPYPRIYPEQYAYMVDLKKTLDAGGNCVLEMPSGTGKTVTLLSLIVAYQQYYPEHRKLIYCSRTMSEIEKALVELRALMKFRAERLGHEEEFRGLGLTSRKNLCLHPSVKREKSGAIVDARCRSLTAGFVKEKREKGENVETCVYHDNLDLLEPHNLIPNGIWTLDGLLRYGEEKKQCPYFTARRMMEYCNVIIYSYHYLLDPKIAERVSKNLSKDCIVVFDEAHNIDNVCIESLSTDITQDSLMRATRGAQNLEAKINEMKDSDQEKLQSEYEKLVEGLKGLDEGRQEDAFMANPTLPDDLLKEAVPGNIRRAEHFVAFLRRFIEYLKTRMKVRQVISETPPSFLAHLKEYTFIEKKPLRFCAERLTSLVRTLELTNIEDYRPLQEVATFATLVATYEKGFLLILEPYESDTAKTPNPVLHFTCLDAAIAIKPVFDRFSSVIITSGTISPLEMYPKMLNFSTVVQESYSMTLARRSFLPMIVTRGSDQASISTSFQVRNEPSVVRNYGNLLTEFARMTPDGMVVFFPSYLYMESIISMWQGMGILDEVWKHKLILVETPDAQETSLALETYRTACCNGRGAVLLCVARGKVSEGIDFDHQYGRTVLCIGVPFQYTESRILKARLEFLRETYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRFMKKRHQLPKWINQALLDANTNLSTDMAVGAARAFLKQMAQPFSAKDQEGVSIWGMKDLKRHQEKMAEDLIVELRTQREDEERERKRREEEERRRLEEERDRVSDYEMDEDDEAEMMALDARIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG71</accession>
    <name>A0AAE0JG71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_209304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682178.1">
        <property type="nucleotide sequence ID" value="XM_062821908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG71"/>
    <dbReference type="GeneID" id="87859062"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="592" mass="64038" checksum="3305F4D23C35F845" modified="2024-05-29" version="1">MAADETTPLLPNGTGTATTSGNNVDTNNSQLSSPNTDSENTTNNHHDVNNNNTKAKWTLNPLTLLTRVHVETRILLAAFLITTSFSFTQVPIFYAFHLMECDDFYTHHPPYTGLGDRCSRNEIAAGTATDFSFLAMSTTICGTVNLFFAGWLVKKIGLRLALMAQVLVPAIRVLTQILGVLAGGRSGIVIFQATQLITVLGGPVGYILIINIMVGEVVSPARRTPVFGMLQGCFMLGQAVGYLTGGMIGDAWGIRRPFEVAFVAFLVSTAYVQLALPYVSPESMAGGGKKAGGPKAEGVAAGFFAPLRVLAPQRVRLRSGKVIKHLGVLVLCTGVFLGVLATDFAAMLIQMYATAVFEFRQSDNGWLMSEFALMRAVFLIVLFPRIISSGRKWYAKRQSKRQPRRESMSDQRDPATQGLLIQPDQLEAPMGTLAEEEPMVTQPPTETEDTHFDLFFLRWSLVADGLLTSCTALATKKWHIYLAAAMLPFASGTAPAAKGVMTEMCSPEQRADALNALTLVENIGRLATQGFFGFVFAALAEAGKPHLTFYCNAILAMIAASVLIFSRFPPNGSELIEADDAEEHVNGSNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG99</accession>
    <name>A0AAE0JG99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_547179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682425.1">
        <property type="nucleotide sequence ID" value="XM_062829495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG99"/>
    <dbReference type="GeneID" id="87866649"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="598" mass="63748" checksum="F173A9F9671EEE40" modified="2024-05-29" version="1">MSMRLHGADLQSLASKARVGWDGDSEKHNSALSTPRVSGDKFPTQAASPAAPGFGAVKRRLVSINQSYSSMPQARQLDYRVCQPSSCFHIVFEPRHRNRIMRRPNVFPLTVRFRLQKKGELGVSGLEMDIKMWIDALSSQDFHEKETMKALLQLSLFLAQGLLVFGTTTTGGPPKCNADNCYRALFPCPSPSAVSVASGFCATITASGTTATNYPTRATNACGLTPDRYISACKCGPTCSYTTTTATATTTVACSSATPSNGGLIYGDFECPSPSPPWTVQILDPSFSLSTTTSNSFTGNRSLRASLTGPSTCSGVCSNARIISPPLPITPNTDYKLTLATFFPNNTNGGTGSTGFIGVQINGRAGLTIDANDNPGRERWRFTQSPWRSLSTETTAGIRIEWIGPPSFLDTITFAPVTAYCGPSPPPLGILPGGEFECGGLGSWTQQVPDPGAIAGVVTLPIPGQVNPDYRFGSHAWRVVSPQKPNPANQDSLVSARLISPTLSVIPGRKYLISFSTYFDAFGIGFMGLMVNNQPIYTRDPGDQGQGGVGWWGPNTVYWTAPENVSSAQLKFEAVMAEAGTMGVDAVVMVEVNPAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGB2</accession>
    <name>A0AAE0JGB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AKAP7 2'5' RNA ligase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_466645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682046.1">
        <property type="nucleotide sequence ID" value="XM_062826867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGB2"/>
    <dbReference type="GeneID" id="87864021"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="273"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="458" mass="49184" checksum="59F1E25B8A1339E4" modified="2024-05-29" version="1">MEESRTQPLPAASAASTLPSPSKSSPAEEQQPQLQTASEDTAKSQPKSQPKGEDNTTINKNQNQNKKPNKMPPKPPPTHFLCIPLVTASSRSQLTRSLAAFREEVTAPGNPSSSAYGALPVPEEAIRPVGTIHLTLGVMSFLEPRESKGVKTGRGGGGQGQAGQVGGSSGRDGPQEDNGRRDRSRSRSGSRSGSEEQGPPSGSGSLSGLRKLEEAKALLKSLKLSEIWQEVLRQSQTRATAVPMPRDSNGGGAPIAIGTAEEKGEGVEAGMGTVIREVPPQLQSETGKKEEEEDLKITLKGLHSMQSPSKAAVLYAPPVDPLGHLQRFCERVKAEFVQKELMMEEGGRPLLLHATVVNTIYVKGGRGRGQQQQQQQGGGNRGGGRGGKKGHHGHRGGGNKRERLTIDAREILERYEEYTWMEDVKVEKVAICKMGAKKEMVDGVVVDEAYEVEEDVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGQ8</accession>
    <name>A0AAE0JGQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_587494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682617.1">
        <property type="nucleotide sequence ID" value="XM_062830979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGQ8"/>
    <dbReference type="GeneID" id="87868133"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-met"/>
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    </dbReference>
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        <property type="match status" value="7"/>
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        <location>
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    </evidence>
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        <source>
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        <source>
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</entry>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S."/>
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                <person name="Andreopoulos B."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <position position="1"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="278" mass="32170" checksum="9177B2657704189A" modified="2024-05-29" version="1" fragment="single">NLLRLWAFLDNREMWHSLLQVARNDQEQWPKWLRDIALNEGRFLNIATLLLRYSMIEARESKQSSYIIHPVVHRWISHIQDVAGKRVFLRLAVMLIGFSVSDCTTKNYWVLQRRLLPHAERCSWWMGELEGGEYNIADITIDHATHSLGNLYLDQGWLKEAKTMYQRALEGYEKALGPYHRLTLGTVYNLGNLYETQGRLKEAETMYQRALSGYSAALGSSHAKSLLVVKNIASLQLAKGSLSLQGLIVKFANIDNQVHREKLNRRSIILRQMKLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Westerberg I."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHD8"/>
    <dbReference type="GeneID" id="87858376"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697:SF1">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="460" mass="49658" checksum="C6D0884600F7E38F" modified="2024-05-29" version="1">MTSRSPSPPPMIPLPRDWSINDNANANSDNSDNDNEDDAQSDISIPYSSLTESTTSTAGGNGFLTPTSSDAHTVAGAEGVNLQTINSVLHEMDSSSSYHHDEHFTNTILMQWRAVNHDEIERQIVNNRNRDRNGNNRDRSDTATTLSTGNLRLHNTSQTSTTLASEGGVGVGEGGGARLDGNGQTRRRKGGGGGEGGEGSKSSLHDSSSSSSSSSIKSTTSPSNMSHDHDDLEFPPLTILSPAPTAPHTRSSTPAPTATHTRPSTPTPAYESAPSSPSGDALKSKPQPPPSKPRPPPSRYTRHAAPVPNQTFILIESSTGRALTLIDGSLRLVPVPDPDLISITKKSRLELSGRVDPCVTKGQCNWHWHCVETSGWLGFRNAASGTFLGHDMRQNIIASAYKHNGWEWMTVRPTPEGKGGYLMVTHWEKLYKIEFLKDRGGLVARDTKEVEGTVWEFVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI60</accession>
    <name>A0AAE0JI60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">B0H65DRAFT_172858</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI60"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="50"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="323"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="579"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="814"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="678"/>
            <end position="680"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="685"/>
            <end position="691"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3348328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1103" mass="122756" checksum="69633475374AD980" modified="2024-05-29" version="1">MASRLDCLVAAVCPESVSSWNWVSLAPLDKCDSSDLPTVFTMSQKVIDSRIPALIRNGMQEKKRSFFVVVGDHSKEAIVHLYYILSNANMKHNKSVLWAYKSKLLNFTSHRKKRENKIKKEIKRGVREANSEDPFELFISLNDIRYVYYKETEKILGNTYGMAILQDFEAMTPNILARTIETVEGGGLVILLLKGMNSLKQLYTLSMDVHSRYRTEAHDDVVARFNERFILSLGSCESCLVVDDELNVLPISGGKAVKALPRPTDDEEVNPAKKELDKIKESLEDTQPIGSLVQLARTTDQAKALLTFVDAIAEKTLRNTVTLTAARGRGKSAAMGVAIAAAVAYGYSNIFITSPSPENLKTLFEFVFKGFDALDYKDHADYSIIQSTNPEFNKAIVRVNIHRNHRQTIQYIRPQDAHVLGQAELLVIDEAAAIPLPLVKKLMGPYLIFMASTISGYEGTGRSLSLKLIKQLREQSRTGAGVKDVVEVDRTSGKAAKDTETVFTGGRSLKEITLSEPIRYAQGDQVEKWLNTLLCLDATLPRSKLNTQGCPDPSQCELLHVNRDTLFSFHPVSEKFLQQMVALYVASHYKNSPNDLQLMSDAPAHELFVLTAPIVEGRLPEPLCVIQVSLEGKISKQSILNSLSRGSQPAGDLIPWLVSQQFQDDEFASLSGARVVRIATNPDYVSMGYGSRALQLLVDYYEGKFANLSEEAGIIVPKSAPRVTDAELTNASLFDDIKVRDMNELPPLFAKLSERRPEPLEYIGVSYGLTQPLHKFWKRASFAPVYLRQTANDLTGEHTCVMLRPLGDGTDPSWLGAFANDFHRRFLSLLSYKFREFPAILALTIEESAGAGAKLDPSNEPTPLEKAGLDKLLTPFDHKRLESYANGLLDYHVVLDLIPSIAQLFFEGRIRSNLQLSGLQQAILLAIGLQRKEIDAIAGELTLPSSQLLAIFIKIMRKISTHLASLVEGAIAKEMPQQIGVSTEDASAAHDDEIIENNFVPLNQSLDDELAEGGDQAMKAIRAKQRELIDSLPLDQYEIDGGDAEWREAEKRVAKATKEGKSNPLVSVKTKKRKAEPVYEEEKPEKKDRGDKKGKKPKHDKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIA3</accession>
    <name>A0AAE0JIA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_161226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683056.1">
        <property type="nucleotide sequence ID" value="XM_062821239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIA3"/>
    <dbReference type="GeneID" id="87858393"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3347974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="124" mass="13914" checksum="632E3AF0197EC0F4" modified="2024-05-29" version="1">MSNLFRSLASSMRALSLAAPRATAVNTTKTVVSTHQTRCLSQALLSRHVCTPMCSHNRPVAVSQSAKNGLQSKQQSRGMKVHSAIKKRCEHCKVVRRKANKRQNGYLYIICPANPRHKQRQGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIJ4</accession>
    <name>A0AAE0JIJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_158064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682957.1">
        <property type="nucleotide sequence ID" value="XM_062821192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIJ4"/>
    <dbReference type="GeneID" id="87858346"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042135667" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="850"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120642" checksum="6823393D340D622E" modified="2024-05-29" version="1">MLLTGAKGALWLAFTSVVSALGQEPIISFDKAPGALQIAGGKISKGQIRVAKNEYWGVIRAAGDLALDFGRVTGTNYTLSNGEKGAGPAVYTYNPVDNMNNTHYSTTGVANFTGPAYFDPSPSDTVIIAGTIGHSEIIDSLIASKKLDVSATKGKWESFTSQVIKNPIQGCSSALVIAGSDPRGTIFGIYDVSEQIGVSPWYFWADVPTRQNKNIYALNKKKVQGPPSVKYRGFFLNDEQPALTNWVEEHWERTPYGAGYGPAFYGLIFEVLLRLRANYLWPALWGTMFEVDDPGNQPFADAFEIVLGTSHTEPMMRAQNEFGHFYQGPWAYNLNNETIDDYFRYGVQRAKPYARNSLWTMGMRGTGDTAIEGLGVDHIVDMLTTLVHNQRQILAEGLGVSDVTTVPQAWCLYKEVMTYLSAGLEVPDDITLLWADDNWGHVRRLPLLNETTRAGGAGVYYHFDYVGDPRNYKWINTVQLSKTTEQMHMTYARGADRIWIVNVGDMKANEIPINHWFDLGYDMKRWGVDSTEEWAKTWAAREFGSKYADEIGDIMIKYAMYASRRKFELVEPQTYSVINYNEADAVLQQWAELRAHAQAVYDKLDEAYKPAFFEMILHPTIGGEVVHRIYAGGAKNLLYSGQKRNSANEVINQVLAASDEDWQLQERWDALLGGKWRHFMDQTHLGYDGYWQQPMRNTLPAMVYVQTHFVSLAGHVGVGVEGSNATVQGDDKYHSNSGNNLSLPPMDPYGPATRYFDVFSRGTKDCAWQAAPWQPWVKLSQYNGTVGPKGSDTRVHVSIDWSKAPKATFSSTVNINVTNSCRGLDRNGYAEPMVQVPVQIRSVSSNFTKGFVESDGHVAITGAHYSAIIPPKQKSKLNDKVTYHTLNKYGRSGSGIGLVPLNTEKLTVQTAPALEYDLYFFTNHTKANVTVLMSPALNYLGEWAPLEYGISLYPAGASAPSEPKMVRPVGPTVGANLPEGWGYAVADSAWGTVGNYTTSTFAVPQEGAYKLRFWALMPGIVVQKIIVDMGGVRKSFFGPPESFMVGRDQVGKYNQTSFLAEVDTLGGLYEKQENKGRRALFLDAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIM4</accession>
    <name>A0AAE0JIM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_538903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683438.1">
        <property type="nucleotide sequence ID" value="XM_062829101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIM4"/>
    <dbReference type="GeneID" id="87866255"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="203" mass="22909" checksum="93F8C788A2B88316" modified="2024-05-29" version="1">MSSQQDFVTVQITVRIPRTLLNNTNSHHFVIEVAPGQEHQTEASTTTHIPHTISGQEKTSTTTAEEDPSSLTAYFKISDKSISKHNASQPQVVHHLEHKPNKHSSRPSSTLSAQPSYTMSTNMKPTTTASLLKELSNNPAENAALQFSIEAKHVRFTDLQLYALRFWYDQYHILNHDVPRACLLSYRQTYQTLSFISNSSFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIZ5</accession>
    <name>A0AAE0JIZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_571700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683197.1">
        <property type="nucleotide sequence ID" value="XM_062830486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIZ5"/>
    <dbReference type="GeneID" id="87867640"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3348115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121167" checksum="26FE352A4FC764F1" modified="2024-05-29" version="1">MSVLPADVTAELSQLLQALQSADNSIRSQAEEHLQNNWTSSRPGLLLMGLAEQIAGSSDASVRSFAAVIFRRITLKTRKATPTSEAATDMFLSLDNAEAVAVRTKILEAILAETDRNVRNKIGDAVAEIARQYYDNDQNWPELLQTLFNLSQAADAGKRETAFRIFHATPSIIEKQHQDAVAMAFAKAFTDESVAVRLAAMEAFAAFFRSLGKKNQAKYFELLPQLLNILPPIKDSQDSDDLSQALIALIDLAESSPKMFKTVFSTLVGFSISVIQDKELTDLCRQNALELMATFADYAPSMCKKDASYTKDMITQCLSLMTDLGEDDDDAAEWLGCDDLDTDESDSNHVAGEQCLDRLANKLGGASILSPIFGWLPSMMNSPAWRDRHAALMALSAISEGCREEMIGELRQVLDLVVPALKDPHPRVRWAGCNALGQMSTDFAPTMQKQYYDIVLSAIVPVLNAPEARVKSHAAAALVNFCEEADKSVLEPYLDNLLSHLFQLLQNEKRYVQEQALSTIATIADAAEQAFAKYYDTLMPLLMGVLQRENEKEVRLLRAKAMECATLIALAVGKERLGADAMALVQLLASIQQNITDPDDPQAQYLMHCWGRMCRVLGRDFLPYLPEVMPPLLELASAKADIQLLEDDEQIEQLQTEEGWELVPLRGKTIGIRTSTMDDKNMAIELLVVYAQVLEGDFAPYVADIMEKIALPGLAFFFHDPVRYMSAKLVPQLLISYKKQYGPGSNELKGLWTSTVVQLLDVLSAEPAIDTLAEMYQCFYESIEVIGTACLDETHMTRFIDGVHSTLEDYKDRAAAREEEQGGEDGEDESEEMQMAIEDDQTLLSDMNKAFHAVFKYHGASFLSTWSRLLPTYSSFLSSNDTTQRQWGLCIMDDVLEYCGAESIHYAQYISEPLLLGCQDASPAIRQAAAYGIGVAAHHGGQAWAPLVGQAVEVLFKATQIPDARNEDNVYATENACAAIAKILHFNSSQVANPDQVATQWFETLPVLNDEEAAPYAYAFMTQLIEKQHPVVVSQPAKAFYYVAQALEVDVLSGQTLARVIAAVKNLLQATGTSPDPVLQQFGPESQQLIRERFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ84</accession>
    <name>A0AAE0JJ84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_170432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683332.1">
        <property type="nucleotide sequence ID" value="XM_062821359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ84"/>
    <dbReference type="GeneID" id="87858513"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042274597" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="114"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="228" mass="23454" checksum="28A1C4D1B6C4BE60" modified="2024-05-29" version="1">MKLKLFTLGVVSLVSLALAHPAAPTTPASPTPSSLGLVPLPLPLHLPNNNNNNNNHITGNFSHSCDQITLMNKYFLAATCSPITIEPGSAAPSPSEDGNHDFQVQVPPAPEFNQLDLNMCIGFDQGTQGTGTGTAGRPESGGGGVYGGRLIWQALGKFANYCTDCNLTTGRPGLSELECSCVPMTGGPGATSVTVLDLDEGVENRNGTLVCRGGMGSGIGPGPLLPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ92</accession>
    <name>A0AAE0JJ92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol-binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_439704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684000.1">
        <property type="nucleotide sequence ID" value="XM_062825436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862590"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="219"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1739"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1906"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1743"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1768"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1917"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1961"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1989"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2029"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2045"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2064"/>
            <end position="2076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2076" mass="228769" checksum="8C1CB3380219C1FA" modified="2024-05-29" version="1">MAGIEQLEIHSKSYIVRWVKVEEGHTISWSVQPHKKSINFAIVKHPGTGGTTAGSQTFEATATPEQPPTETAVSDAKSGLFRRDASTAQDQLAKKGFIPIKWHGKCEADKVTVGTYDVTSAGMYGLVLDNTFSKQTSKTATFVLLTYPTGAPPQTAHHLPTVQAGSGSNASRTSLGTGATPRLGATNSDSVDSLTSHVAGGRSRAVSNARSEGGFVPGATYHVGVLLKRRRKKGQGFARRFFSLDFTTCTLSYYHNRNSSALRGAIPLSLAAIAADERRREITIDSGAEIWHLKASGPKDFNDWAKALEKASRIARGLETLNNGASLGVDRPASRPSTSVPSAQQEDEREWAQVESLVSRIAGTRDALRRLVKDMAAEKQAPGVSQASLLSPNTPAIAEDSETYFTPSTDTRRPFWKRKTSNASPGAQPGVQATTGAALAVPSPTSATAVNEERNTYDNCAALLSDLDSVVVEFSQLLSKNKRRRLPSQMLPPNMIPAASRKSYESTTSTIDEFFDAEAGETGGAGQNQVMIIRQSEEDTPGSDAEEVDIHDSSSVSSVEEEEEFEGVGTENHDSLFPVKPKSLAPLPITDTVTRRTTIPAATVPPPSLIAFVRKNVGKDLSTISMPVSSNEPLSLCQRMAEQLEYGQLLTEAAKKTDAKERLLYVTAFAVSQFSNSRAKERATRKPFNPLLGETYELVRSENEVPGGFRVLVEKVSHRPVRLAVQADSALWSFSQSPAPSQKFWGKSAEITTEGRVRVSLHLPDGTDELYSWHIATVFLRNVVYGEKYVEPVGSMNVNNETSGAKAVVEFRSAKGMFGGRGEEVHVETFGPDGSNTGQALTGTWTSSLKTVPGGKEIWKAGSLVPNAANTYGLTTFAASLNEITPLEKGKLPPTDSRLRPDQRFHEQGDLDSAEEWKVKLEEAQRVRRKEMEEGGEEYKPKWFVKVATGQDGEEVWKLKGGKEGGFVDWCSDGGRCTPMSLGVKQLWRALSNSNGARGLSLIPRECAPALTRAAPTSRSTLRALHSRLPLSDQSQSEDIHSHDELEANDVQHTTTEVHDSGEYKTPTDPSRASPPPPPPPPREAQEQAQTRARNVRDKGPGLVNRLAKVPVRAHPALESVFVRPVTEYPDQYETRGSVRSHRKDNARQKKVLGTRVPTDLSDWRATLRKLYQWTPMCLPEQFADTVKVIMPRETAPRLLSDSEWSVWDIKSRTGCRMVLYRYGDAGYEEGTEDHDPYLILKGYHRSVNTAIDEILSVTRRVTVISRTQDTEEVLWDGKVAGQDLSLPAPSVYVYARRTPSPLAPYNVNIRADEFPKPEEWTRKTFEEYVDVLIKSRMPPSLASKLYPEHGRHELAVIEQLVAVFNDEVAAQFVSNAAFKMALHYMTRGGETWRPELLSLFNYAQSGRRMQLDVEVFNILAEAAVKTRSLYRFSQVLYLMVTRGYQPNLRTWILFLRMFEAEEVKRYVLQAMNDRGLFNAHGALRMIANEMAPHDAYRAVQLRWDVPTFLAKQDELYGRERKWVSIDAINKIIHVFGSYSKFAEIRQLLDLIFTGELVAYPDQVTVNTILTHCKAQRKLDLAVEFIQLFEGHNADNNTKTPLKLDKMACDILFDLANWQKKPHVLSTIWRYAHLVNATTSEMRRRGTNLLAMDETELKKEKLVRRLKLGDEERVQFLRQLLIGEFIQANGGEEVFGKVIAGIAKGEQEHQRGVEEMAEQEEEDNEGIPTALGDWFQSQSLVDSSSPTTPPSSSSSPTSSNPSQPNPNHNILQSHSSEQTEPITWGNIYGSFQSWSFTSQFLHLEPSAPIGSLLQQALERDRELHLALREDGLDRLDVEELMKPIEIPTQSRTKPAFAEVRRLFMREREAMKRGVEKVGVKEGDRDGDGEVQEAMAFGTAMRRQAVDQWSGGGGGDGEAAAAAKNASVDEAASAAAAAKPKPSSPPKSKKVVVTREQKQQPAAATAAAAATVEAEAEVEVEVEAGGSPQEEAHKRGERKATPSKPKTPPAPAPVAEAQKTSPTIPPTLSTPPTTSSPPSTKTPTKSSKERKTKEAGVEPPLPSSSEKRVKWEDLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJH9</accession>
    <name>A0AAE0JJH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_90783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683828.1">
        <property type="nucleotide sequence ID" value="XM_062831554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJH9"/>
    <dbReference type="GeneID" id="87868708"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="133" mass="14709" checksum="C1E1ED9A7C14E5EB" modified="2024-05-29" version="1">MRPHPEIRPHHQPTPFPSFWTGRHKQPPRPRGRLMTSTKSGVRGLALIARKAKNSECPFVLPGDRYRSSSKLCKMNGVGSFVGVFVSSVGVFVSSVGVFVSSVGVLYLLLEFCIFCWGACIFCACTGWEVLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJN5</accession>
    <name>A0AAE0JJN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_456223</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684174.1">
        <property type="nucleotide sequence ID" value="XM_062826277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJN5"/>
    <dbReference type="GeneID" id="87863431"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3350879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="309" mass="31920" checksum="A86F94383902D92B" modified="2024-05-29" version="1">MGFERGGRGGARGGGRGGFGGGDRGGRGGARGGFGGGRGGGAPRGRGGPRGGGRGGPPGRGGRGGARGGAKGGAAGKKVIVEPHRHKGVFVARGGKEDLLATVNLVPGESVYGEKRISVENASKEEGGASTKTEYRIWNPFRSKLAAGILGGLETIYMKPGSKVLYLGAASGTSVSHVADIVGPTGAVYAVEFSHRSGRDLINMATRRTNVIPIVEDARKPMAYRMLLPMVDVIFADVAQPDQARIVGINAKQFLKQGGGLLISIKASCIDSTAPPEQVFASEVQKLREDKFFPKEQLTLGTLTRIPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK67</accession>
    <name>A0AAE0JK67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_101885</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684176.1">
        <property type="nucleotide sequence ID" value="XM_062820448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK67"/>
    <dbReference type="GeneID" id="87857602"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="13">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3350881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="331" mass="37061" checksum="28B76571C27200C9" modified="2024-05-29" version="1">MSGGWNTIESDAGVFTDLLTNLGVKGVQFEELLSLEPDALAQLHPVYGVIFLFKYPTNEPYRGTDKPLDGTFDYDASERLFFAHQTIQNACGTQALLSVLLNKADPSVSQEGDAGYIDIGDKLRDFREFTIALPAEIRGEALSNSELIRDTHNSFARSSPFIDETQRRPDEEDGDAFHFIAYSPIGGTLYELDGLQPAPISHGACTQEDFPQKVMDVLQRRIARYDASEIRFNLLAMIRDLRIRAREFADEDLLASEERKREAWRFENALRRHNFVGFAGEILKGVVSAKLVAGGSAYDDWVNQGKKKMEKRAAEQRARKGGEGEDVEMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKD0</accession>
    <name>A0AAE0JKD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_487874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684296.1">
        <property type="nucleotide sequence ID" value="XM_062827706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKD0"/>
    <dbReference type="GeneID" id="87864860"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000228">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="449"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="657" mass="73819" checksum="337AADAFB539C080" modified="2024-05-29" version="1" fragment="single">MMNKLRIFNTPGRFRLIQGCRLLPTTPLSLYLPQNKNFNATKTFLSSQPSTRCIHTAKNSSEADKLCSEIGIQNLAGKETAKANETSSPGPSEPSHQATGKQDRVSSPRQGERENKNGNGKQEQRQGKRQGQQQDKPQQTRQQQPQDQLQAQAHQTGDQMYPNHFGYQPGYPPIWQGGFVEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQNQQRFPQYGMGYGMGYAPPPDVGYGFVPPVHLNTFAPGMAMPNWQQPPPPSYSGARRGFNTNSNNTPQVPQPPNFYRSRNFYRPRSPGPYSRGRQYNNDNTYANNTHPDFHRSRSPGPYSRQYNNNNINNHSHQQQIPPTSNKLSNPPKLNKKAKAREAAAREALAQAQAQRSSKMPPSSSSFSSSFIPRGPRGDIPREASDPIVPPSRASGGVPKPSQAYKMRASFLARSVPGSEPRPMLVVIDLNGTLLHRPSRKRPSKFVERPFAKDFLQYCIDTFKVVIWSSARPENVGLMCKQLLTQEQLGKVVAIWGRDKFGLTPADYNARVQCYKRLTMLWEDPTVGASNPEGEPWNQGNTVLIDDSAEKARSEPYNCITLPEFLGNLDEKPEVLPMVREYLNILAHQADISTYIRVKPFDINVDSSKAVTGDEGVALASPPAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKH8</accession>
    <name>A0AAE0JKH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_103231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684211.1">
        <property type="nucleotide sequence ID" value="XM_062820462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKH8"/>
    <dbReference type="GeneID" id="87857616"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="579" mass="65599" checksum="5187D1351B9B9B4D" modified="2024-05-29" version="1">MAAPDREKQPEKDDHSSSSEEDQNALEVSFDQSSPYRRKSSIVDSDVRVPLHLRRSQPARTECFVHQFLDAQRRPPRRQNTLHGHLDVTRENGQDRVPDPKGVPSTLSNNAADPRARECSITNANSSDTSDAGQIDEKEWKSEIVRIESTQLTETDLDETHSRLLTKKQLSEMAWGVRELSRRLGSVRLKFKIKTIFVLTKPYDQELIPKTRALIRWLLDKERDVRYTVYIDKALRSNMKFDAPGLIEEVRKDYVESGEISEEAGNDISQRLRYWDEELCRARPHTADFVITLGGDGTVLFASWLFQRIVPPVLSFALGSLGFLTKFDFDNYQETLTAAFTEGVNVALRLRFEGTVMRCQKKRRKLVKDGDRKPGGTEGPDGQNGNDTREEEEEERKRDLVEELIGEEKDDERTHRPDGTYDVLNEVVVDRGPNPTMSSIDIFGDDEHFTSVHADGICVSTPTGSTAYNLGAGGSLCHPENPVMLVTAICAHTLSFRPIILPDTIVLRIGVPYDARTGSWASFDGRERIELRPGDYVTISASRYPFASVQPQGKRSEEWIKSINAKLGWNTRQKQKSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKL8</accession>
    <name>A0AAE0JKL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_506557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684383.1">
        <property type="nucleotide sequence ID" value="XM_062828067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKL8"/>
    <dbReference type="GeneID" id="87865221"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="38"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="499" mass="53553" checksum="4DE71FEECEF1E295" modified="2024-05-29" version="1">MSSGPVEPYEGVTGVANDGGNPLLEDLNRYYSAGDFGWIMTCSALVLLMVPGVGFFYSGLARRKSALALIWLSLMSIALVGFQWFFWGYSLAFSHTGSAYIGNLSNFGLMKTLAQPSVGSSKIPDLLFCLYQGMFAAITPALAIGACADRGRMLPALVFMFIWTTIVYDPIAYWTWNGNGWSFKMGGLDFAGGTPVHISSGAAALAYSLMLGKRNGYNKVNGLPYRPHNVTHVVLGTVFLWVGWFGFNGGSALAANLRSVMACIVTHIAACVGGLTWVLLDYRLERKWSTVGFCSGAIAGLVAITPAAGYVPPWSAFIFGVVGGISCNFATKLKFVLGIDEALDVFAEHGVGGIVGNLLTGIFAAYVFPPSSHISLKKPSTNFHHSDYIAALDGATVIDGGWVNHHYIQLAYQLADSVAGFSYSFVMTCVILFLLNLVPGLSLRVDEHQEEIGLDDDQLGEFAYDYVEVTRSLDHVIPGLTAPNSTAGSISGRDPEKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKM8</accession>
    <name>A0AAE0JKM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_456994</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684446.1">
        <property type="nucleotide sequence ID" value="XM_062826333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKM8"/>
    <dbReference type="GeneID" id="87863487"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000781">
        <property type="entry name" value="Meiotic recombination protein spo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="233"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3351151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="465" mass="51502" checksum="68D0AD12436C0B0D" modified="2024-05-29" version="1">MYFCPIRNQFLNPPSQPTTSNAHGQFPPVRQRSSVGSGSIGVSRNVVAIPQRHSNDDALTKIEALFETIVDAVSAGSSIVIPYRRSTNAQAFNLTASASNPRDGRHMDSVRFPGRNPQELRRFEALFRIIELSHEALLSGTLITKRNIYYQNMELFRSQSVVDEMVDNVAFTLGVGRNDLNIVATAKGLLAGQIRLIMRGGTSINCAESSDSGVLLPSISAVEKVDFQSVKWLLVIEKEATFRTLSASRYHTVSRAGSGILVTGKGYPDLATRKFLAALHSVRPRLPILALVDFDPHGISILRTYQYGSQRLDHEERTKVPGLRWLGIRSSDVLSKTVVTQDHSANSQGSQSSQDFSSQESIAYSVDAFQDQRPAKRPRTRRTKSHPSDCTAALNEGDRGKAVSVLRDICATARLDATGREHKLELQRMLMLNIKAEIQAVDDFGDITSWLDERLLSHSRYVNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKS9</accession>
    <name>A0AAE0JKS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_123525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684792.1">
        <property type="nucleotide sequence ID" value="XM_062820707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKS9"/>
    <dbReference type="GeneID" id="87857861"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042219578" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10730" checksum="A49823A427FB0440" modified="2024-05-29" version="1">MIRHSRNGSWTRLWLLLFFSHLEVEGGFGALQIAMRPQRLLRERPSASNIPTMWIRQFIKHVLLMIVIEMHSACNFKLHLVGVRNQDGHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKU3</accession>
    <name>A0AAE0JKU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease III homolog</fullName>
            <ecNumber evidence="7">3.2.2.-</ecNumber>
            <ecNumber evidence="7">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="7">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NTH1</name>
        <name evidence="10" type="ORF">B0H65DRAFT_519849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="7"/>
    <dbReference type="EC" id="4.2.99.18" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKU3"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="9">
        <location>
            <begin position="251"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="842" mass="94704" checksum="C82FA1E916DE0360" modified="2024-05-29" version="1">MRTSHIAKETSRLFEGATTAMATPATPRRSTRLSTLARFAYEANNANANASSSSAPVDLRSSPLRATKIEEDHEEDEHGITFGSDIEDAVKSSGSPAVKVKRRNPIVTRKRKRVTTTTTATALKTEESLPAPTRIKTERKSTRIINQTAEAEVKSDSEIDMNDIPVVGTSTTSSRKRTARKPARKTTDALTGEVKVEPPSDWEEVYNLVKEMRISGPAANAAVDTMGCERLASNNASARDRRFHTLVALMLSSQTKDTVNAEAMLRLKKELPPHTEGAESGLNLENMLAVEPAVLNELIGKVGFHNNKTKYLKQAAEILRDRYNSDIPDTIEGLMSLPGVGPKMAHLCMSAENGWNRVEGIGVDVHVHRITNLWGWQNPPTKTPEETRLALQSWLPRDKWKEINWLLVGFGQSVCLPVGRKCGDCELGLRGLCKAAERKKVIEGRKRREVVKEEKVEVETEVVRFKGEPKEEGGEEDERDMVIKREKREERIEVKEEEVARVRDVVVNEPIPPAVREAVADQAVKMESIEDVEMEDVDEAQSAVANIEPTIEHSPPIIKQEGMRVKRERLADEEEDNEEADQKSVVKVEVLRVKQEQSVHGLEAEEEENQPPQVVKREPARVKQEPNIGAEEGESAHRHCVVKREPERDLATVKQELDFDEEEEGDDLQPQVVKSEHPRVKQESELPEHGEEENHRPRIVKRESLNGATIVKPEPSLNEQGAEDRQGRSVKREPLLERAIVKQEPNLGGSEEHEADYRPSIVKREPGRVKQEAEDEQEEEKELDKPAVKSEPVEREQEPVRVKREAADEGKQEEEEEDVHVKTEHGGRVKVEEGMARIKLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKV1</accession>
    <name>A0AAE0JKV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinetochore component CENP-S-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_99611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684112.1">
        <property type="nucleotide sequence ID" value="XM_062831674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKV1"/>
    <dbReference type="GeneID" id="87868828"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000098">
        <property type="entry name" value="Apoptosis-inducing TAF9-like domain 1 family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3350817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="112" mass="12491" checksum="DDA31E2980866663" modified="2024-05-29" version="1">MADASGEDVQERLKSALWFAIGKMVDDESLRRNMNATPQFIGALTELVWTQIENVAIDLETFSQHAGRTTVTTDDVLLLARRNSDLQSVIKDCVDRLKAAKAKEKTRAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLC3</accession>
    <name>A0AAE0JLC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_419734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685062.1">
        <property type="nucleotide sequence ID" value="XM_062824232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLC3"/>
    <dbReference type="GeneID" id="87861386"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3351767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="173" mass="19009" checksum="2A0274233C02F5E4" modified="2024-05-29" version="1">MTMSEERLFRFSKPEWLNSAWARNAGVYAAGAFFSLAFYTLLDSAVWSHSPLNASDVHIRFVDWLPFIFSTLGMLIINSVEKARLSQDSFSYSGSGVAWKARVVLFLGFASLAGGMAGGVTVFVLKYVVKDVGFPALRMGVENLVANGLVGLSAVVLWISQNMEDEYSYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMJ3</accession>
    <name>A0AAE0JMJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vps5 C terminal like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_458812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685012.1">
        <property type="nucleotide sequence ID" value="XM_062826427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMJ3"/>
    <dbReference type="GeneID" id="87863581"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="170"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3351717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="575" mass="63740" checksum="24B2FA1A77911D5E" modified="2024-05-29" version="1">MEDPWADSAIGGESNNSSSTVPQSDDTAPAGSTTAPSTSSTLAPSTNTSSSRPSRLTPRRLVAQPTRLEAVEDDPLGPLGASTPAATDTPLAPPQPPLKEQLPLRTTLPGGPNQIGGGGARRDPHRIEEEELYNDTPSGPRQPPPVPPAQPSSVRTSMQPSVSIEQAANPTFHIYVGDPHKVGDLTSSHIVYSVRTKTTSKAYKQPEFEVKRRYRDFLWLYNTLHANNPGVVVPPPPEKQAVGRFESNFVEARRAALEKMLNKTAAHPTLQHDADLKLFLESEAFNIDVKHKERKEPNLGESKGVLSTFGISVGSGNKFVEQDDWFHDRRVYLDALENQLKGLLKAMDSMVAQRKAMAEAAGEFSASLHALSTVELSPTLSGPLDALSELQLTIRDVYDRQAQQDVLTFGIIIEEYIRLIGSVKQAFSQRQKAFYSWHSAESELQKRKTSQDKLLRQGKSQQDRLNQVNAEVADAERKVHQARLLFEDMGRLMRAELDRFEREKVEDFKSGVETFLESAVEAQKELIEKWETFLMQLDAEDDETVFYRPPVVQANKPAGDTAVDRARARIDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMN8</accession>
    <name>A0AAE0JMN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_504272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685511.1">
        <property type="nucleotide sequence ID" value="XM_062827896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMN8"/>
    <dbReference type="GeneID" id="87865050"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="239"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3354133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="462" mass="50207" checksum="A704DB901B847B3F" modified="2024-05-29" version="1">MKDVEDIHRPMLNSLQSTSAKMKKIVLSVNAGSSSVKISAYSALFGQAPIQLAEAQISGLTAPPPTLRYTRRGEKVIKDEEVKDQKVSTQADAFDILLKTLIDDNGVPEISSKEDIAYICHRIVHGGDFVRPKLISDETYHNLEKLTDMAPLHNSTSLAIVHRCMSDLPKTTLNIACFDSQFHHTIPEHIRTYPINQDIARSNHLRKYGFHGISYAFIARATAEFLGKKVEDVNIIALHLGSGASACAIKGGKSLDTSMGLTPLAGLPGATRSGSVDPSLVFHYASDVGKLSPASTKELHISRAEEILNKESGWKALTGTTNFGTITAALDSSSSSSSNLSQEDLAKMRLAFNLFVDRICGFIGSYYVSLQGQVDALVFAGGIGEKSDRLRATVVEQVGCLGFGPVDKEANETRVKEELDDDHAVIEIAPGSKRGGHRVLVCKTDEQFEMARACAEDGEFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMT6</accession>
    <name>A0AAE0JMT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA polymerase</fullName>
            <ecNumber evidence="22">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">B0H65DRAFT_448787</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="22"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685905.1">
        <property type="nucleotide sequence ID" value="XM_062825914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87863068"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 22" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 22" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="28">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="27">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="25">
        <location>
            <begin position="934"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="24">
        <location>
            <begin position="1192"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="26">
        <location>
            <begin position="1774"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="471"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1859"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="1867"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1895"/>
            <end position="1930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAK3354527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1947" mass="219317" checksum="7E4FF92428508E52" modified="2024-05-29" version="1">MDVFRVRLNCIDHYQATPTEYDPQFAQDVRFSHSRKPPKVPVIRVFGSTETGQKVCAHIHGAFPYLYVEYDGSLEDAKANEYIAKLRASIDHALAVSYRKDPVRDRPMYVARITLTKGIPFYGFHVGYRFYLKIYLFNPVVMSRLVDLLQQGVIMSQKFQPYEAHLQYLLQFMADYNLYGCDYLDAAMVTFRAPVPKHDENIQGHETEHPWDDAKIPSELITDDYSLPRASHCSLEVDICVEDILNRKQVKERRLHHDFIEGEQPVSSQEKLVHSMAGLWTDETNRRKRRMGITDPEVNPFPPEVLVSMSADPRQSQVMGWVHETEYRAGIQQLVAQEQDNTDGCQKTFSGFVQPVPFEETIKTTLESVEDLYPENLSQALQVEAQLFHMNAQPHSSIDVDERTILQLAGERNANRTPPEHADRMSPGEPINGVGEGFGVGDSITYDTGRRRRVHQPRTSIRHKLFKIAKAYSSKQPANTGRQARALGPGERPRRYPKHPRPPGEVDRDAPAKRQMLQAEGSREAVHLKANAPQSASEMASRKAQSKAREAAQPGPQRRPQGNPPERAHEKSNKRVHEDAQAKAHRKAQQRSLEQGLEHDQKQDQQKTQELAGEQSRGEVQGAVPENLTSTKPARTVQPIEPSDQDPTVEQPLANILKVEPPKPKASQPTKSAMKQSSAKESQGRKFNFPVVKDPQDPNTRARLSQKSGSQKNEEMVAKKQLAFDPQPTILGSSAQAKPSQTEPNLKSSSKPFDSAPAASAPVLLWSGSNKMFVLDSKPPSLSEVRCTMQVHGLPDVIYQDAYYSKDEDVPPKPREYAGREYRLDGSSVPWLPDFDPTGTSPATFGEKPTSGADWPMLEAIYEAQQEDCAMRSWEIAEPPPSFKEVSEWWADKQKGRNTKRRLFTPLRIKTARSQVAGATPKNKHGFRYSEKEKSTSVQHQAQYMSTMSLEVHVNTRGKLVPDPEEDEVQCVFWCLRSDENALRGTQAPDNTVRGIVVFSEDGLLAEKIRKYTSVPVLQETTELDVMVRMVEIVRNHDPDIFTGYEVHGSSWGYLIERARIKYDLDLCDEFSRMKSQSNGRIGKDADRWGFNTTSSIRITGRHMINIWRAMRGELNLLQYTMENVVWHLLHRRIPHYSWKTLSDWYLSGRPKDLDKLLRYYLTRTRLDIEILEKNELIPRTSEQARLLGVDFFSVFSRGSQFKVESIMFRIAKPENFLLVSPSRKQVGAQNALECLPLVMEPQSAFYSSPLLVLDFQSLYPSVMIAYNYCYSTFLGRIVSWRGTNKMGFMDYKRQEGLLSLLKDYINIAPNGMMYTKPHIRKSLLAKMLTEILETRIMVKSGMKQDKDDKALQQLLNNRQLALKLLANVTYGYTSASFSGRMPCSEIADSIVQAGRETLERAIAFIHSVQKWDAEVVYGDTDSLFVYLKGRTREQAFDIGQEIADAVTKMNPRPVKLRFEKVYHPCVLIAKKRYVGYKYESRDQTVPEFDAKGIETVRRDGTPAEQRIEEKALKILFDTADLSQVKSYFQEQCHKIMRGAVSVQDFCFAREVKLGTYSTSGRGGPAPAGALIATKKMREDARAEPQYGERVPYVVMAGAPGMRLVDRCVEPEELLNNSHATLDADYYINKNIIPPLERIFNLVGANVRTWYEEMPKVQVLRKVVLEDEDAAAAAAPRGPLFGLLLGASPSKKGAAAAAAALDTEDVLGEDGEPLPPDVAAAQAQARKTLEAFLNTTICTACGVKIKRRPLGVGLARELGMLDGGEEGAVDRVGLPLCRRCASDPPTLMVDMQTKVSRAEKGYAEIIKVCQSCAGFAPPEDEVPCDSKDCPVFYSRVKQRTKMTAEKRVMEPLIRLFGDLELGKEGGSEDEDGEEEEGNWELEGGSEVVSGGGRMEVQEDAGRRYEEEEAKSEAIVRGKGRAVSEEQRENDGFLDSSFRGLKAASLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMX1</accession>
    <name>A0AAE0JMX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_413596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685633.1">
        <property type="nucleotide sequence ID" value="XM_062823852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMX1"/>
    <dbReference type="GeneID" id="87861006"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="477"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="614" mass="68088" checksum="1F854549D82214FC" modified="2024-05-29" version="1">MMLRTNLPDHIRKSMGDEVVSVIHAPPSFENWKSSDNYSRSSLSNSVSAASAESSTISPPASEASTAQSPPTHSRPMVNTNVKPVAFGLDAPTPQAQRLEDVFANETSRLRSSTTSSLELIPESHEGDSRYEDADDFLTAETTPSEQTEIQALSAALEECWTLCNTLANLSSIHRERVFNSSGTPDAHEKAWKSCWKLCKRLYQSRNDYPESHNIARTNLDLCRDFCQSLFDVRQKKDEVADSILRVSFELNNHLYSAQDTRSLPEAFRERTLDFYITLCHRLMKQRNDSPEETDSLLRACWALAEMLFSLRQNRRDGKAPDEELLGSAVQACWELCDIFREGWTQIRPDRGTPRPSHINFFSPGSYGLQSLSSNHQSDSRSNAGSRASIRSKRESLRSLSDLTDRPRQKPIIPETPVTEFEDTPVSPDASPQMPNIMVLGPSNDRSDSRGGRWSSSASNLSGYSQSSQHTSSTATTATATIEDMNITRIKVLIVKAAMNIGFSRETAAVDGKGGSAALQTFVKSLPTGSFGSLPMHATLLQNYKNLVLTDSAFRASASLPPRGKRISAIEIAKSVNWMMMRSGQYGFLKDLFRLVFGFQVEDAESRKNASVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN23</accession>
    <name>A0AAE0JN23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_448827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685915.1">
        <property type="nucleotide sequence ID" value="XM_062825919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN23"/>
    <dbReference type="GeneID" id="87863073"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="282"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="808" mass="90734" checksum="0F10C5A15F8AC532" modified="2024-05-29" version="1">MARYLTPAKIGLLALIELYVEEAVPNDAIIPVLSFLTSHILDSDLQSTTSTAPGAANRWQRAERSIGLVVSVKDFEDLLLPFPAVDRLPGRRLWDRFLEKLWGIDSLDALQEFFSRRPLVLARTREELRRMAELGEEAPSGILLARNSPLGAFVRKAVLEFTRLQFHHSAELWKAFVKYRQPTVSYWRRRNPQCGRLSFDSVLMECQHEWGSFTDGIAVTAYGGMLMGEEDGALPVSTDDVESLLEFQIDQIQKYGARVPAEIKAKFHAMLRDSHVVPSLSHYLNFSDAWRSGDYPSAFDYLHRYFDYTMQNRDRLFYHYALMNLAIVQSDFGCHKEAMATMLETISTARENKDNTCLNFCLNWFYHFGRAHPDLVQDLEANSMIGSGKEALAFLRAKAKETGMLVLRSSALLSEAKLNMANGESIAGAMEHIVRSSQIIVERNMKSLFGSQLSVTTSLWDRLGISYLSSMTSEVFLRVHAPSACFDDELKMVCRLAGILAGKGKYDEAFAKLEDGIDKNSLRAAKPNQYWHLYRGLVKLRRALHHNDLDTAETLLAQLLQVGSEELDPDVVFIIDSLHIEALIRRKDFDAAYEKIERLIAKCRDDHRDLSLRIRLLLAKAHLFDCMGRPERGFSITMRAASLAWRARLLTLLWQAVGALANILNAMSEFPAAVQLVEAVLPRSMESENAFNTGMLYSILADARMGQAGKAGKARQAATTMGETTGAAAAAASLMNNQRTELFTKAHEALECAFNHFSAAEDLEKQCETLAKRATLMKVLGDDARAEEFAARYMALRRQSSSGDHSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNE6</accession>
    <name>A0AAE0JNE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_16651</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685916.1">
        <property type="nucleotide sequence ID" value="XM_062821305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNE6"/>
    <dbReference type="GeneID" id="87858459"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04813">
        <property type="entry name" value="PA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000364">
        <property type="entry name" value="Protease-associated PA domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042236431" description="RING-type E3 ubiquitin transferase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="719"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="415"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="771"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3354538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="859" mass="92255" checksum="B29D4D5EFC9125ED" modified="2024-05-29" version="1">MRTPRVAILVLFFSASVFLFCRSIASSRRASPAVSHLSPETSGLRSFFSFRAPFTLFPPNAAISLFDDNSTFFPARPAIFGPPLPKDGLSGQLWAGSGFTDDNLQDGQGEGELGCSDVVGWEGAPGRLSLKMPKQSPAGDTTGSTTSDHKKFKRSNIVDGPAVDHKTTSKTHSSKLDVEMVVDDGTDDYLHQGFRTDKDAFVDTPTSSSSGHADIQSIQETAEITGKIVLLSRGGCGFLQKVKWAQRRGAIALIVGDNQKGGPLIQMSARGNVDNVTIPSVFTSRTTAHLLSSLMQPGSFLQDILDESGYPVSNSQHSGKTKKRKPSKWSAKHARSTPETNPKRQLTKVTGPQGSVADSGAESSPSHRSWFSRLFHWGPGSDSATDKSRPPSSGSLDWVIVDDWSDEKDKVIKTGLDKASKSSGDDSALASDSGRNREDGFQIGVQDWRDPDLASSSSSVRHGGDSSVDDEQEAGTFGASSKQPGKTSQSDANGPQGGSITPGSGRYDPEALAGSQSGQRNSDSSSGSSGGLMSKIFGDDDGEDFPPYEAPSFYAEKPSSPPAAVNRAGNREGLWITITPTSGASPFFDTLLVLVISPLITLTVVYALLILRAKIRRRRWRAPKSVVERLPVRTYHTVPRSPSQSSRVPSPSGASTPTTPLLQGPSRSRPRSRTTTGVPEPADLLRVDSALQVARVPAHEKGTTRASQWKKYMGRQRECAICLEEYVDGVSRVMSLPCGHEFHAECITPWLTTRRRTCPICKGDVVRSLARGSSSTPRYEPYRDDDSEEDDGGEASGSGDIMFRSDSPARNTDVEQGRAAASAPERGRGGFDISDGWFSALSNSLGARPTFLSRRTDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNK3</accession>
    <name>A0AAE0JNK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_543940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686006.1">
        <property type="nucleotide sequence ID" value="XM_062829257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87866411"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7603" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="552"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="916"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1397" mass="156761" checksum="EAC36934E0E42FE9" modified="2024-05-29" version="1">MATFVPSSPDERGFDSGPALEQQQQQQQQQQQQQQQQQQQYQEQQYQEQQHQEQQHHHPQLDTNEATTLLNSSPPPARSAVVEPVGAAPAVPSDRTPPRFSNKYPQLPSLLPPHGLGPSTSDETEETLDQLETDHQFPPLPTIDHQRPTPSPSKGRSQSLAYTPAPIKRKPLSSSASPLATRFSSPGRNYLDIIRDLPRPESRFSRSCSLDSPTLYEFPAKFGPPLNPPRPSAAHASDLPANPEYNSNNQRSTSTVSDHSVQHQGPDFYNTGDLQSTKTLEESPIIASAETGRPLSVSPDRHLSAGSLGVTTRPLDHNDEVAAPYTNATATTNTFSQETHDGRNPIVKPSTMSLSSRKSPPPHLNLAPAEDSEHRQRAFPLVATPGESNNLRQPLPKSPASSQLDANFYGNWATTPQSSTTEFSEDKEDISPIPSPSPYSLRRSIHADESPRLLRTPSHTNAKTERLEDYLQTPPPSETSQYQIDEMEDELRAIGAELAASIRREMDLEDLVDKLQEQVNNGNPNASGKRTSDYFSDSGHSSSKFSDDDQAKEEITLVKRKAEQERAQIRLELTTKLQDERIRRRALDEQIQELSKRASMIDVAKVQNEETSDRLKELEATCDDLRRRLSEESQTRENLEDLLSAVKGELENASNERDNLRDEIVPQLRARVEGLETEVAENEKLAYDATRLQQEVQSLKTENEELGKIQEEVDLLKAENAELGKYREEYEHLKSGNTDFAKLQDEFEQFRAEHTGCDRLQEELQALRSGNSDVERLQEELHAIKLEHSECSKLHEEVQLLKSANAQLSSQQNELQSLRTESAEIDDLQQELEALRFENTELRKLEQELRTLKSENNELKQTGTRMSMVLSRSTSVAGTNSSSIKRGGRPMSLARSNTTKHLAAAEPRTEVLADRLKDVEAQRDALHSALRSLLERQEFQNRENAKKIKLLEQERDRLLSSSPRGGYEKEVATLRDEIAVLRRRAEEAIDQKWEVEKGLGGLKMNLDRAEQEITSLRSLLREKDILIPEGFARSSYMSNYSNEDALVPVSSASLERAYADLQATYSEALVRIKDLEDSTASNEAMQLAIARLEHSLSTVVTERDMAREDNVAQLAELESLRESEKQHIDAELTLAEQLSDSARRVEELAQQVRVQLAINATLRARLADTVARGEANQRVSTERIASLQKRLRELEEQVIAAQTNAEERVNRHEEELQTLKESHNIHLLRLREPAGSAAAMRGLPPRSFPPKSPLSPMFSMSLASKSDATPRTTRMSSPFLLSSSSSFYSSSHASTYLRPRASGVLSSAAAEGNMAEDVTILKARVAQLEGALMAADSEMQEVVSRMNMAQIEVMTLQEEREEAVRQTRKLQKMMEEERVKVFEERFKSFAGATEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP42</accession>
    <name>A0AAE0JP42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Granaticin polyketide synthase ketoacyl reductase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_37521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686514.1">
        <property type="nucleotide sequence ID" value="XM_062823694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP42"/>
    <dbReference type="GeneID" id="87860848"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF13">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27876" checksum="C721A580DF0BCFF2" modified="2024-05-29" version="1">MDSPLVALITAGSAGLGAATARLFARNGIRVVINYNNDDARASDLVKELYKISPLRTGAYGRFNYVALKANLAEKNQIGELIDDTVNCMDRLDIVFSNGGWTRLRDINDLDDNVNEEDWDMCFNMNVKSHLWLMHAAKPHLDETEGVFITTASLAGVKVSGSSLAYSVTKAAQIHLAKGLAQIAAPRIRVNTVSPGLMLTDWGLQFPPEKQKEARERSKLKRLATVEDVAEQVLCFVKSKSVTGVNVIIDGGMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP64</accession>
    <name>A0AAE0JP64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_41740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686640.1">
        <property type="nucleotide sequence ID" value="XM_062824086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP64"/>
    <dbReference type="GeneID" id="87861240"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="441" mass="46515" checksum="520F14ECF0636604" modified="2024-05-29" version="1">MVSFPEWTTNPIPGVSLSAGGLLALADLSTVAQRTAITGGSSWLDSLLLAPGLHYQQAADELAKWSGSSATAVVDAGTGPGPGASVTRPTTFRINNAATILYLQKIARPGQTVTLDVGTIPAIRQRLRIRRSESGLHATVWAVDDLPDLGWLSHVLYLISPLLTIAAIVLVILFQDWWTLASLLALMLSRILNIYIIKQRSKPRLLPSLPFPFHPFHPPSSPSPSPNHHHKPNPITSLLISLGSDSPSHPSTSSIRLRGLSEDLYAITATAWLRSKTHVEGYLEATAKVLVYMVAAFSGNMTQVGAMIMMVLLLATAGLLALSNANAKMFRVNGRVVVGERERVFLGEEGSDGARKGKGMGMAGGGGGEIPQRQRRRTGGLGQGVYPAANGGGGVVGYGNGNGNVIDAWPSTSDTEGRGYAASDNNWAEKGQAGGGDYGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQB7</accession>
    <name>A0AAE0JQB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_555180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687210.1">
        <property type="nucleotide sequence ID" value="XM_062830013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQB7"/>
    <dbReference type="GeneID" id="87867167"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="176"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3355832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="436" mass="46169" checksum="02CD5B88459553E0" modified="2024-05-29" version="1">MPDHNNNNHTARDAAAALSMNLSSSSPRQATASPRSRDSSTSTTATHSPTSSPGPGGAGEDLPQWARPSASNIRRLSSGRPYSVSRHASHHRSSSAAAGGGGGAVTIFLGLSLLQKMAILVALAIFFSLSVVALVYSHAIFASLGPLAEKWRALPFGWLICFGLVFMTAFPPIIGYSTAVTVAGFVYGFPWGWPIAAAATVAGSTCSFLASRGVLAGYVNRLVGRDKRFVALGQVLRRDGLGVLAMVRFSPLPYSLSNGFLATVPRLRVGGFAVATAMATPKLFVHIFIGSRLALLASSGDKMTTRDRAINYISMLLFGAVGAVVGYLIWKRTMSRAEELAHEEGLDGIDSLAAAAGTTAAGEVHRTTDGTLEVEDDEEEDYADLEGNTGGRLLVGGNGGREGDLRRQSSDSDISLWETDRYRDSWDEEANLEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQC5</accession>
    <name>A0AAE0JQC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen Asp f 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_50763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686906.1">
        <property type="nucleotide sequence ID" value="XM_062828154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQC5"/>
    <dbReference type="GeneID" id="87865308"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042064984" description="Allergen Asp f 4" evidence="1">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="30650" checksum="B3996B7474B76A2C" modified="2024-05-29" version="1">MQITSLLVLAGVLGASAMPSGHAHLHRAAHQQRDLKFYKAEKHFPIPIPSATSSSVAIPSSTTAPAAAATSSAAATQDDDEYIPFCGENKNTKRVTYAQIMYTGNTGTTNGCKWNSNLMTVPKSIADKYNNRMFFTNVANEPYQVVCGNKMGSDGGLNGMFKTPANQQLVFTLAPGQTEVVVADANTQGVCAFAPEEVPTTQNGQFAGNWAEFDFENSSNGGWSGADCSSLVAQAAGMDVPGCQICGHGTCSSILPGGAGTNAYTKGMEALDGIGLNLMADLQITLNISVGFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQH4</accession>
    <name>A0AAE0JQH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitin deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_453647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687315.1">
        <property type="nucleotide sequence ID" value="XM_062826156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQH4"/>
    <dbReference type="GeneID" id="87863310"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10958">
        <property type="entry name" value="CE4_NodB_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="76"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="307" mass="34467" checksum="67935E006E2588F0" modified="2024-05-29" version="1">MPRLLPRLFAALPSKILHRRTRRARMATLLLLLLILPLILLLPFYTVYKPPSSLIRYFSQRWTDVLWRLWLPPHRKIVALTIDDAPSDHTREILAALKAGGAHATFFVIGGQVRGREEILREIVRQGHELGNHGMHDEMARQLGDEELERQMREVEGLIRGAYEAEGRVWPGGGSSGAGAGAGGTTTDGTDTTTDTRTREGGTVEDKVIEGKYYRPGSGFFSERMLSLVRKLGYRLVLGSIYPHDAQIGYAWLNARHILSMLSPGGIIICHDRRSWTPPMLRKVLPEMQRRGYKAVTVTQLLEEATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR90</accession>
    <name>A0AAE0JR90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="10" type="ORF">B0H65DRAFT_505957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR90"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3356191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="255" mass="28446" checksum="C2B980C413D6A7CF" modified="2024-05-29" version="1">MCPPTTSTSENNNDHLVQSSDPNHPANLIPALCAKFWTLGWVTGTGGGASIRSDDLVYLAPSGVQKELMKPEDIYVLSLAAQAQSLDKRQRVYLRSPANFKPSQCTPLFLAAFTKRNAGCCIHTHSHWAVLVTLILETQGSKEFLINNIEQIKGFGKGFGKSGNLGYHDTLRIPVIENTAHEEDLTEFLEEAMDQYPDTYAVLVRRHGVYVWGENVHKAKTMCESLDYLFQLAVEMKQLGLPWVTDIEPTIPTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJ39</accession>
    <name>A0AAE0MJ39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_543196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676682.1">
        <property type="nucleotide sequence ID" value="XM_062829216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJ39"/>
    <dbReference type="GeneID" id="87866370"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042264255" evidence="2">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="256" mass="29972" checksum="8AC57B01DA279501" modified="2024-05-29" version="1">MVRKFCELFLLVVCLGCLWLLSKFRPGCFPEKKQKDLDKMSLTPPQTPQRPRPSRFIYPPEVHRSKERVQATLQSIINPLFDLLYIIYQGHPYTRPENIIQTLDRIQSDYMRQLTSHFFISPVSEQPLALYKLRHYFGCLEDIFEDEFCGIEGDLLNEYPTKAIKAAARAGWHERRWQGVVGRMVRDGSLRKDWGEMRLEDFVKVATNYMVFLVSLKLAGVERDSSLKSKKPPSIKDITRRTINKDESSNSRERIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJ64</accession>
    <name>A0AAE0MJ64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_83295</name>
        <name evidence="4" type="ORF">B0H65DRAFT_84548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000014">
        <property type="protein sequence ID" value="KAK3334270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676608.1">
        <property type="nucleotide sequence ID" value="XM_062831467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJ64"/>
    <dbReference type="GeneID" id="87868621"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="224" mass="25608" checksum="166EE86CCBB1918C" modified="2024-05-29" version="1">MGRKRADSPSNIKFQQPDRSGPKEKTLLELAEERGLFAQAQKKQEENDKYSKTKIKKIPIKPENPNDHDNEPLSPGAERFLDTTLYTMSLTMLHFTLDVLVQNQYSADRIVWPKVWMRAFQALFVFGFLIYTLHAHSSNPTILPGLPARFQNHLRQVIFLIMSVTSGCYLIHITNTYGYLAVMKQAPPVGCLWVWSVIELQLPWAVLSLAVAGTYLKVRGYDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MKG7</accession>
    <name>A0AAE0MKG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_553342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677179.1">
        <property type="nucleotide sequence ID" value="XM_062829955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MKG7"/>
    <dbReference type="GeneID" id="87867109"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3335013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="124" mass="13160" checksum="E2B61127C478AFCD" modified="2024-05-29" version="1">MPPIFFLDVGVSSDSPFYPSQAGIFANGKILRLDSPNQPPNGSNDIWSISCRKSLVTGLSAPDGIDVDPSANRMYWTNMGADVNDMDGSLMSFTLDGSDKKVLLGGADGVFTTPMQLGRPSAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MKM2</accession>
    <name>A0AAE0MKM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_481164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676745.1">
        <property type="nucleotide sequence ID" value="XM_062827621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MKM2"/>
    <dbReference type="GeneID" id="87864775"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041997898" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8288" checksum="84A24B0E8BEEA9E5" modified="2024-05-29" version="1">MPSIFRLLLLLLPVLPPPPVIFGIRHLSPTQPPWPVTSPILRYPPSPTARYDVVLRVNEVLVMGKHAPHPLIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP71</accession>
    <name>A0AAE0MP71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_252582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679173.1">
        <property type="nucleotide sequence ID" value="XM_062822495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP71"/>
    <dbReference type="GeneID" id="87859649"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH64" evidence="2">
        <location>
            <begin position="30"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="505" mass="53789" checksum="AE445684D413BE2A" modified="2024-05-29" version="1">MATLTIPPTQQSTTATAAATTTPLDAPITTQTTPQTLTISLQNNTPSPTVYAYITGQTLSGGTLFILSSTGTTPYTFPSPITQTLTPIPSSLISIPLNPPSSPPKTVTIPRLAGARIWYSVGSQLQFFLNPITGQEQDGKGRGVALVEPSVTNESDVNYEKEWGFAEFTFNEYQLFGNVSMVDFVGRCPVSLGVIRDTGRAGDVQEVEGMGYGSGLDRVIDGLRQTGGDWEKLVVRRKQDGVVTRVLSPNSAVVMASQRGERLFSGYYDGYVRDVWEKYKREDLVVDTQNKWGVVRGRVDTATGLLTFPIPGSGTGGKITFGQPSAADIFSCSTGPFAFPPLPANPTEADLDVQAFRGNVGARLAAAFNRSTLLINPNQPAGEVISTFYKSNAVTNHYSRVVHENSPGGRGYAFPYDDVSRTEEENVAGTVAAGDPKVFVVAVGGGKVNFAALGTAGVSSAVTATGGAEKGEKRVATEDRGMRSGRGRVKRIRGLLRRAVGWVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ06</accession>
    <name>A0AAE0MQ06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_433253</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678650.1">
        <property type="nucleotide sequence ID" value="XM_062825057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ06"/>
    <dbReference type="GeneID" id="87862211"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="106"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3339290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="625" mass="69217" checksum="0239D81DE839BC42" modified="2024-05-29" version="1">MRTSVLRQAGLCRAALAARHLQISSKPSAALLSQVTRAAAVQSLPSASLPRFYSAEATVQSNTAASNGLVTRFADLASLGVHENVVRAITHGMGYENMTEVQSMTISPALKGKDIVAQAKTGTGKTLGFLVPVIQKIIAQDPDLAHRFGGKRARSDDIRAIIISPTRELAEQIGEEARKLVKGTGVIVQTAVGGTQKNAMLYKTRQQGCHILVGTPGRLNDLLSDSHSGIDAPRLSTLVLDEADRMLEVGFDEELRQIINYLPDRKVLPRQTLLYSATIPKDVVGLARSYIDKNNFEFVQTVKADEVLTHDRIPQYIVPCKGFENIYPTMLELVEKAINESKTNPEALPFKAIVFLPTTAEVIMANAIFKRLQWKFRYIPKTWDIHSKLTQGARTRAAEEFKNARTGILFSSDVTARGMDFPNVSHVIQTHTPPNREQYIHRLGRTGRANKPGQGWLIVPDIELHVARSRLPGLPIKRNDELECASVNAADSGADKPANFEHILDAASRLPEDLFRDCYSSYLGGALQSVDRQALVYALNDLAKFGWGLPEPPAVRASIMKHMGRVQGLRVETREHSMRPMGSGPGHRRDLPPPRRRQSDDPFENVLHRAQDLDRRPTRRQQASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ23</accession>
    <name>A0AAE0MQ23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_467857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680103.1">
        <property type="nucleotide sequence ID" value="XM_062826928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ23"/>
    <dbReference type="GeneID" id="87864082"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF10">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3342310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="529" mass="59833" checksum="CAAC8B22B35EA553" modified="2024-05-29" version="1">MTGANTIAAALERHATTVTRLSSQISSFYASRLPYRIFHGSTNSTRPPTQKGNTKFVDISSLNNVLSVDRQTKTALVEPNVPMDKLVEATLPHGLVPPIVMEFPGITAGGGFAGTAGESSSFRHGFFDDTVREVEMVLGNGEVVKVRNPEIAAKSEGVTGEVEKGDLFRGAAGAVGTLGTTTLLEVQLMEAKKFVKTEYKRASSVAEAIRMVREETQRGDNDYVDGILFSKDHGVVVTGKLVNELPSDVPTTKPQTFSGAWDPWFYLHCQEKTLSSQTATDYVPLAEYLFRYDRGGFWVGAAAFQYFSWVPFTRLTRWFLDDFLHTRMMYRALHGSGESARFVVQDIAMPFETSEEFIDYTSSSLGIWPLWLCPLKRRAPPTFHPHTTRPGTDPADEKAQDDMMLNIGVWGWGPDKPAEFVAKNIELENKVHELGGMKWFYAHTYYEQEKFWKMYGGREWYDQLRKKYNAETLPTVWDKIHVDADKAGKKQRHWLLAKKPIGGFYGIWKSIQSKDYFLHRKAEWKWKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ71</accession>
    <name>A0AAE0MQ71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_428139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680253.1">
        <property type="nucleotide sequence ID" value="XM_062824737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ71"/>
    <dbReference type="GeneID" id="87861891"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000577">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1780.10:FF:000005">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="62361" checksum="38212E890E17B944" modified="2024-05-29" version="1">MTFSILTDDEIRSLLDNLTIDEFESFRKNLRDALHEYSTGAQTPGQALIHQPERTVVRSGVTGATTLFMPSCSPAGHGVKVITLSSAEQIVKSTQEEEAGQDASNPLIRPTGAITLFNPNGSPRGIIHASTVTAFRTALASLCLVHKRDHVKTITVFGCGEQAYWHVRLTLLLRGSTIKHVNVINRRFSPSCGAMLRRFYGVSPATKAREGWTDTQFGVLTPSYGDYERLMRDQVRSADVIFCCTPSTVPLFDGNILTERDARRKGRLIVAIGSYTPQMREVPVELIQQAVKIHDHAGKRIINLSKQAVEGGVVVVDTLDGALKEAGELIEAGLGPRHLVELGELVMLHRIKLSESDDSSRASTDVDTDSLSASASTLTINSAPTEEKDSSSSKESSEKEKRPRHSRHLSVQSIHNLVRGASRSRSRSRNPDSADADYEQRKKEEKEKKKKKKEKEDELARWLQKGNVIYKSVGLGLMDLTVGMQLVDFAEQKGERNGVGSIPLMGLQGKEMVEVGLGLEPLDVGGGGGHVVGGSETSTEPGTGLGHKSGSSRLDSSGDSQESRDQGPGEIHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQE7</accession>
    <name>A0AAE0MQE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_427803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680493.1">
        <property type="nucleotide sequence ID" value="XM_062824710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQE7"/>
    <dbReference type="GeneID" id="87861864"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="80" mass="8690" checksum="DA3E469B997C86E4" modified="2024-05-29" version="1">MPAKETSDHASETAEHVENVTTPTAGMTYVASPKVTLTALALEVLRVQILEKILREVKDEEAASQAKKQRASRAASRAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRM9</accession>
    <name>A0AAE0MRM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_588839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681783.1">
        <property type="nucleotide sequence ID" value="XM_062831013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRM9"/>
    <dbReference type="GeneID" id="87868167"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3345170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="120" mass="13156" checksum="BB93042676CDB0A0" modified="2024-05-29" version="1">MTDGDVPIHLALRRGPQGGKLSITTDIITFQVAVRPRCESQQVYSHLYSTERTPDTDFLCANDTMISDAELYRLAIVLGCSAMVLIVLHHFLETNAEDLETDVVKEKKAAKVAAAPAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRQ9</accession>
    <name>A0AAE0MRQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_200504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681857.1">
        <property type="nucleotide sequence ID" value="XM_062821779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRQ9"/>
    <dbReference type="GeneID" id="87858933"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000629">
        <property type="entry name" value="RING finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042261811" description="RING-type domain-containing protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="539" mass="58194" checksum="6B61F569B2DFCED0" modified="2024-05-29" version="1">MAASTVASALGKMAPRRPLFFLALVISVVNALSSVPKLSDFAMDQYLTLQLTVPSGSGDAPPVRHPVVPLTEAVGMNQSAIARESIKIEGTMVPTEEGDWLEFIDSNSIAYLNCDHSNSTSFLNQLMVKAPKAILLFSLTGAGCRRDSTDDWNYTTIFTMTNRIDAQDTLNLTMSGSTATITGDHEETDDDEDEERSGPGSPVAMSILYSITGLITLLFLVIIATGAIRAHRYPERYGPRTGYGGRPSQSRAKGLARAVLETLPIVKFGENPPAKPDPDLELEQQPSRSSQDPAPGAKSSAIQEEVPSSDKSQGPVTVSSVDASEQASSATVYGAQTGMANTAGDIENTSSDDINLGCSICTEDFTVGEDVRVLPCNHKYHPACVDPWLVNVSGTCPLCRLDLRPHSSIESTNSPADNHSMSSPTAGESTQQPGTSGSARPDTTSRERRRSSRILDLHRLRTASIEERIEILRRHRSQQQQRRSTTGSSLTGDLDNGESADHPHRARLTERFRGRFRGSRPQSQTQSQPTEGNIPTSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSH4</accession>
    <name>A0AAE0MSH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_570367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682592.1">
        <property type="nucleotide sequence ID" value="XM_062830448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSH4"/>
    <dbReference type="GeneID" id="87867602"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="406" mass="44446" checksum="41B653CAD0C753BF" modified="2024-05-29" version="1">MANRNEIHDEIMARLQSRLLSIKVSRHNEQPGSQARVQAQASSKSPVDGSTRRDYFTKAMREEANNDMNLPLCTPSAGPAYQPNPNPTPTPAPSPGPSSALSAFYARWRLERGRSMPADFKTCDGTHNDAPSSAHPPSQTDFFGSYVIGQDALNHSTFSSTGTTATGGGRAATNLPLPTSLQTPRQASVRTWYQPSLCGKHAKRELKVAQTTFAKSQRERAKAKKAQAEALGVSLKQLSKEDLQQRLADTAARKQKTMERRMRAHIKADMRRLRALGYGMGLTAAEMAARMPLGYEMGLTAAEFAARFPPLGMGQNGHGSHSQEEQGHTSSLDGNASDGEQMEVEQEKPESVQGNVSDDVQMEEGLYKSRQINLFGYGLVEVMVPEKTESLQGNVNEYSDDDQMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MST7</accession>
    <name>A0AAE0MST7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_157791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682937.1">
        <property type="nucleotide sequence ID" value="XM_062821185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MST7"/>
    <dbReference type="GeneID" id="87858339"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3347855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="206" mass="22123" checksum="1540FD43D4754D74" modified="2024-05-29" version="1">MAFPSPAGDSDPVLGFYDNFLPVLCLPSLTPEELYTADRLYELGLEMKVAAQQAYGISSTLGPVPSYAGLGLEPALRFPPSSWMTPITPIPHLVNPYLLPGSAAKAVCGHYFTVHVTPEPQCSFASFATNVPGGQNGRQTAEVIEQVVNIFRPRRFSVTLFEAKGALATTPGENADDSRRTLATSSTALLWNTACKTSFSTLRPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTD9</accession>
    <name>A0AAE0MTD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_422974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683567.1">
        <property type="nucleotide sequence ID" value="XM_062824428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTD9"/>
    <dbReference type="GeneID" id="87861582"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042074736" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="29"/>
            <end position="632"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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        </source>
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        <source>
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    <sequence length="632" mass="67130" checksum="3D410A45E555C96E" modified="2024-05-29" version="1">MFPPGLLKACFLSSALLLATATATSGLAQEPISNLLPQQDRITTSNDSSNCRCIPGDACWPSPTEWSRFNQTVGGRLIATVPLGSVCYSSDERYDKAKCAQLRSDWHLTATHYRDSASVMNQFFAHGPGPDGGQCDPFDGDSSPSGQERNHEKCSIGSLVTYSLNASSASSASAATDFISTLSFAHQHNIRLVIRNTGHDYLGKSTGAGSLALWTHYLKDIDFFDFDNTHEAEQQGSVAYKGKAAKLAAGVQVSEAFAAAKAHGLVLHGGNCESVGVVGGYTQGGGHSVLSSAIGLGADQVLEWEVVIPPSSATGHPEPRLVKATPFNEHADLYWALSGGGGGTFGAVVSVTVKAWEDFETAGAMLMFSANSLEDRGIFVKGVQAWLEGLPGIVDIGAGAIWFLLKDVLAVSPVLAPGVKAKELEEAFKPVMEKLDGLGIPYASSFTDFPSFHDAVAAMVAQQNVTDANMGGRLIPRSLVTEKEGAEKLTEALDAIASADGTVAGISVNIERGRKLSKAYPNSVNPLFESAIQIGVFGLPYNHLNFSANIDAQDKITNVFGAALEKVTPGGGAYLNEGDPHQPDWQTTFYGENYERLLAIKNKYDPEGLLYALTAVGSEKWVQKEDGRLCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MTH7_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
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    </protein>
    <gene>
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        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="150"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3348234.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="156" mass="16135" checksum="6ABBF50EB4AD8A2E" modified="2024-05-29" version="1">MLFQTILTRTLSLFLLPIGFTTAAPAAAPGAVIIGEPEASSSSPSSPEDLTTRSFSSRITWYNTGLGACGISSNDGQLVVVLNAAQFDPSTPNGNPNRNSLCGRRIRVNANGRSVTVTLVDRCAGCPYGGLDLSPAAFSALASTSAGVLQGSWDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MTL5_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062831595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87868749"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1427" mass="154401" checksum="81B7FEFAB3CD08CC" modified="2024-05-29" version="1">MAPSSDQAMSRPESAILSPSIKTHSRSRAQSISSDRPSTIAASFMSPPLNVSPEAAFIAASAASQIVTNDHDSHADALLDQHGIEPSAEPALVSPAALQLVNNFLDHLLFNFIAVARSATLAALRPAIIEVLKPKLAKDVINQADEELQEYMGDAEDDVPDSSAAKDLDLELIWKRTRLRCMVYSSLGDLEEEDEDYYMEKELLNPRQEDQSSELVSSAVSMFLTSIIEYLGEQALIVAGQAAFQRIRVKYEKELKEGLRKPGEATEQIVVQELDMERVALDRTLGRLWRTWKKKIRPTVITNLDRGLSHSFSRDSMRSSRGTPTHLRSSSVTETPVPETIPEPTNETGAKADANETETKETAKEETVEEYLSAAAIPLPMGDNDVEEIEGTGLSVRSRSKDGAEERAARKRAVRPKSLLVWPMTKPANPPTPTLSPSHTPLSASKKRSNSLPTPTATPSGSPTRTEPQASELAPLPSVGEKDLEQSQTSDDKQPTRDEKSNDLGGAEMSPVEASLVDAPASLQQAETKPQTQNSGNVETEDEVKGSDESEYDDESMDEEPQILTSSRISISGRSASPTVSEQGRPAPIITTMGRTRTPSIYSARLIEVTSPRSPGTAARNSPILDSSEHMRLSRSSSLRTASIAEERSRYSPDSASGARISGHGGNKSALSAEVAPEDVSPITDDGILEAIPEPPSPDGFEGQGISRGSDPILGSVAERGSPGSSPIRSTPKMTTPTSSAGTFYFEDKSKPPPTHHAQSRPRVSVIAEVAVPEMPDRSPTTSRRTPSNLSAEDIPTSIGNISVQRSRGRSGASETGFISRFPEPPKPGVMVRQETEVRQETASSISSSSSLKSTKSTNKLRPVRTSEEGSIAAQSREDVARNFEELIQSDQTIQFTLTPESMRDIDSQSTRSTGSPNTAVKPRKSQDLRRDSDRSRSSSSNRKKDAKKDKDAHSQHPMPELKRNSNNSPTTSGPILHAIPQPPRAHPPQARDPRISRESVADFAVFIRATGPTGINTAAMNRLSREQSGLPSPVSPPSVPLINRPRLTARDPHTDRDDNSDLIDFIRRGPPTAGNPRIPQAVAPFRKTLDSDQMSIEEAGGKAVDAQLRDVDVRNSQASTDLTNNSMYSFQSSANSQSALLSKNKPQHSTATGRFEGIEEDDVVMPMPSAMPQRKRRGPRDPYAIDLTDEEDFDEDDDYPVKPKRPPTNEESLMDFLNNVPPPPEPTVSPVVTSPKQPQPKKKSSATSLMSRFTRRENKSNVPPSSSGSMSPLSPVRLNESRGLSSRASASSGRGYTPLQVHMPPGVDKYAPSSVNQKSVNHNQNMPMSRGRGMSQSSGTTAPRVAMKRFEPRDAHVAPTSGISDLASFLRNSGPPPSIGEVAPFDFGGPAPSINTVTSSRGGDGAGDSNSFSRVFSRRSRKTSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTX4</accession>
    <name>A0AAE0MTX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_463112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683419.1">
        <property type="nucleotide sequence ID" value="XM_062826683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTX4"/>
    <dbReference type="GeneID" id="87863837"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="113" mass="12081" checksum="DD34391A9E9117EB" modified="2024-05-29" version="1">MLIQATLPKVSLALLGCNGCNGSTRHSQCLVAATANENTEVISTGPPFAVSLQSSRFLTPRSVSVPRVASQAMGDIVHLKIIFTTEVGGFLCRRAEIPWPLRSRELSKAATET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTY7</accession>
    <name>A0AAE0MTY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_441268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682745.1">
        <property type="nucleotide sequence ID" value="XM_062825517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTY7"/>
    <dbReference type="GeneID" id="87862671"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="521" mass="58214" checksum="FE949D33256B3803" modified="2024-05-29" version="1">MTTDDVENESDCWNTSWKSLIVRVISIFRPSADALNQPQPGEPNDARIEGEELNELFDYEAYCMAQNQDHAVANMNDHLSNSEQGFDMDMLNMNDTPGQAGPQVQDQNPFSNLIVDQDQLAQLQFPLLDTAHNNNVPAMNLGIPESAIDPRLRAPKDDGSDAGPEGQANMLLLAQRLACPVGGPRYPHEQRYSLNPPIGPILENFPGQNNSLPLEVFMPSPSVSNKPAPTAGPANAVGSSSGSRSNTPLKLGHKQNSLGPTESPSKKRKASPHNRSQSLAQLQCHSPSHNHGNNNGNPAVRDKRAATVGSSMSPRGPPDQFQGHSSEPGHRVPPSGNGPVQISPATVARRERIQKALMNLDKNWKVAWQKMPGHMRFGFHKELAQAETRAEPLELWEKYLLFKNSEKDKIRVYQELAIERYREREKFMVMLSDHLEKYDGLRSEMQKLREHVFNLESTVQKNELARQKMMGRITDLERSHLELNRGLDERVHILNGKVDRKAQELEEAVEKLKMGEEGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWI0</accession>
    <name>A0AAE0MWI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_416127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686838.1">
        <property type="nucleotide sequence ID" value="XM_062824028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWI0"/>
    <dbReference type="GeneID" id="87861182"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="534" mass="59137" checksum="10C5A8D1F52296DC" modified="2024-05-29" version="1">MPATQAAPTAAGAPQPPKEKIPEGGETQQDYKLVTFSEGDPANPKNWSKAYKWYCTMVVAITCFVVAFCSSVITADVDSVAHEFGISHEAALLPITVFVVGFGVGPMVFAPLSEVFGRQIIYGTTLLMAVVFTIPCAVSKNIGTLIVCRLIDGIAFSAPMTLVGGTLADLWRNEERGVPMAAFSAAPFIGPAIGPLVGGWLCLAGWRWLYWIQLILAFVVWVLITFTVKETYAPTILGRRAKNLRKQTGDNSYVTEGDLDQRPFSERMSVFLIRPFQLLFRELIVLLISLYMSVLYGLLYMFFVAYPVVFEGGKGYSHGQTGLMFIPLAVGVICSAMCAPIVNKHYLTQVQKYNGKPPAEVRLIPMMVSCWFIPIGLFIFAWSSYPRLIWVGPCLAGFPIGFGFIFLYNAANNYLVDSYQHQAASALAAKTFIRSFWGAGTVLFTEQMYHRMGDQWASTFLAFLGLLCCAIPFAFWKFGARIRKRSKYAYGGDDGEEDSHDSDIENQKNERDPNAPLVHDQLALERARSYVSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWK0</accession>
    <name>A0AAE0MWK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_452502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686972.1">
        <property type="nucleotide sequence ID" value="XM_062826103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWK0"/>
    <dbReference type="GeneID" id="87863257"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31222" checksum="3BD7CB03820EA2E1" modified="2024-05-29" version="1">MRNNTISNDETQPLLYPIMSTDDTTTPALTKPPSGRWRRHLTTDIDRTHADLVLIICYLITGLLDSSSISIWGSFVSMQTGNTVYIGLGLAAPHESTRWIKSGTSLLAFCLGSFLFSRFHRFFSPKRRWVLCVSFAVQFAFTIAAAAIVTVTGKPKDSDATEWHVLLPIALLAFQSCGQAVTSRALKYNALTSVVLTSVLCDLFMDADLFNFKVHNRERNQRVGAPVFLFLGALFGGFFAHTSFGVAGALWMAAGLKLVVIVLWLVWPAKPRAVLQHPNGLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWM9</accession>
    <name>A0AAE0MWM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="7">PME-1</shortName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_485884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687062.1">
        <property type="nucleotide sequence ID" value="XM_062827687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWM9"/>
    <dbReference type="GeneID" id="87864841"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000186">
        <property type="entry name" value="Protein phosphatase methylesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="152"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="463" mass="49653" checksum="3EB48DAF61AAAAAE" modified="2024-05-29" version="1">MTEASTAHAMSELQKKWAKARLGSQALGQPPAEIPTATTMPEFNEADEDKEMAGPSPGGFPFDDDSSSASSVSSTGTVIPSPGRALFARPQGFASRSMDPIPWTTYFERELFLKEEAGSDGGSGSSNSSNKPVIITHHAYLTSPVGKGPLFVTHHGAGSSGLSFAVLSSEIRKRLPNAGILSLDARGHGSTTITTPSSAPGEGGETTEQAPPPLDLSLSTLATDLFTVIQLTRAAMHWPDLPPIILVGHSLGGAVVTELAKSYRLGPSLLGYAVLDVVEGSAMDALQSMQTYLSTRPQGFATLKDGIEWHVRSRTIRNSTSARTSVPGLLAPVEELQRQQLHQPRGVAGTEGTAKPWRWKTDLAATQPFWEDWFVGLSKKFLEARGGKMLLLAGTDRLDTELTIGQMQGKYALQVFPEAGHFIHEDLPEKTAIALVDFHRRNDRSQLVLPAKVSDLLAQGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWN3</accession>
    <name>A0AAE0MWN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_55591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687077.1">
        <property type="nucleotide sequence ID" value="XM_062830040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWN3"/>
    <dbReference type="GeneID" id="87867194"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3355699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="643" mass="69137" checksum="055441CD777E20AD" modified="2024-05-29" version="1">MAYNYGPPPPPPGPAPPNNPPAGYPATYGQSPYQQQPQPAAPQRGSYSGRGRGGSDRGGYHQSSHSYSYGQQPSSYGQQAPPASPYPSHQPQPGAYPPPQQQWHSEQHGQHTPQQPPGPPPPQGYAPSYGTQPHYPQAQQPYGAQQPAYSPAPQTAYGPAYAPPAPQASPPPQPWGSHHQPPPPQTSFNTSGRGGRGSHSDRSGPKGQMMGPPIRMGFDGAPAQPPAPAPYPPQPYGAPHAAPYAPAPYPYPPPTAYMPPAHPVYDGAPAASTPRHGRGGGFHQNSHPRHRPQFGGDRARGRNGHAGGNHSRGGKAHSPPTHHQKPDPSGGKKKKRKTNTLGLTPGDESDEDDENEEERLNEMIGADAPNPTTNEELASWIAERRANFPSKAKIEAKRAAVKAQTAEAKAADEKASLLMRQEQKAEKLRKQLEKVESSIKRKREQQDEGDEMRHSEPSSPSTISKSDDEKPEVLTTRPDETVVPPVARKADQSKHCKYYSTGGNCGKRGKCRFVHDPNEREKALKERELNGGKMTLQQRLLLNDKEQEDLSIVQAIKYLQDKGAYKVKKPLDQSSGGITTSNGQPPATGPASLPQNPLKREPGSGLPSIPPQPEAPNGNASASKYPGWNLSGFGNTGVRPNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX00</accession>
    <name>A0AAE0MX00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_545229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687377.1">
        <property type="nucleotide sequence ID" value="XM_062829357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX00"/>
    <dbReference type="GeneID" id="87866511"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3356000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="206" mass="23101" checksum="E2F600787311873A" modified="2024-05-29" version="1">MALETLQIEHVPSDHHVYAALFRDVQNVDFLQAQLIGKNPEFEYAFIDASVIISRTHLLAAIFRALNTLTEGTLQTPNVHSDIVIGLSPTNNISESYRRYGLTPSKTRDVLVIKVVYPKLSSENSTITNEVPTPASIWQHLTTHIQGKPVPLTDEELAKSTDWQKVRKYYKLNGVPGVERIDKADEEGRRREMEGLVVSGIALRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX18</accession>
    <name>A0AAE0MX18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_19078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685985.1">
        <property type="nucleotide sequence ID" value="XM_062821635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX18"/>
    <dbReference type="GeneID" id="87858789"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="800"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="850" mass="94961" checksum="DA14E4DEB0582B72" modified="2024-05-29" version="1">MAEICEPNSLPGGEQNPFVVDDEDDVIQIHDEEELEEQVAEVIDITEDGIEPFEFNRGPRSRPGEEILPSFLLRDQGFIIRPGMTVELKEPEPIGKFFISFVRVTSIARQAFANNVTIRGHGFTRAKEMNGMLPKQLNECCLIALVDTHDPRPCREKAMIDIKPENILTTRELRVTNAAFPQHRDNAVEIAGKRQQIKDMGVLVSRYTYVEHHQIDQNKPREWAFMRVEEEDADENFRVSGNVLVNGWRGGKVPGGSLVPAERTHGRRPMHIHNLDDPTTSTAPGPINVPFNQKYTAGDTFAGAGGASRGITDSGVHLEFCVDNWEHAIASLKANFNGTTIYDTDMHDFIVDKDIKHRVDILHLSPPCQVWSPAHTRPGQNDEKNLAILFSCTHLIEKIRPRLFTVEQTFGILHPRFENFFQSLVRGFTDHGYSVRWKVVNFSHYGLPQPRRRLIMIGAGPGEKLPPFPAPTHSPDVSRNRRHGGLKSLTTARQALAAIDGRRRYPLHQPYLQQFPIPRAPWDGDKPLPYTVTCGAAENYHWSGERQFTPLEYALLQGFPMHHKFAGNYIKKQIGNAFPPIFVKLLYKHLVNWLDTQDNVVRQARIEGVEPFRTPTVRRHVNIERREEDEVTFLSSRKRRQLDAVDLIDEDDNIYNRKRARLDITPSQPKQKTVIDLDEDISNLELDQDNDDARSDSATIRESSVDSPRGSSPSTPFSTSASPYLPVGPPGSSHHTPGLFVSPKPPAPSPLGLGLDPPSKATSSTTQRTQTLPNSSSSNTQSVRRKLFLTVPPPRTEPFSSPSSTSSTSSSATSSSSSAPASSSGSSSSGAEVKKENQKGTKEEPMELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0H0</accession>
    <name>A0AAE0J0H0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_81838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676561.1">
        <property type="nucleotide sequence ID" value="XM_062831453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0H0"/>
    <dbReference type="GeneID" id="87868607"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="224" mass="25092" checksum="CBC605CEAC6C5EE5" modified="2024-05-29" version="1">MPPARQPIPEDLKNVYLMMAIQEAPESTIRTVLRALCGDADYKARIMTLMFNKKLPLKPEATTTAAGTGTPSGSGSESRKRKAPNTEICIQCDELFEEGDKSKTCKHHLYDMELDEDDETWLEMPIFREEISDTPFCRKENPQGFVFPCCGTKGSRSKVNRGCTMGKHRAADGKRTKYPGEEKESSGEEDDDEETEEDEVDENQKGQVEVREKDGDKNEGGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J105_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Cystathionine beta-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_338759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677123.1">
        <property type="nucleotide sequence ID" value="XM_062823609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J105"/>
    <dbReference type="GeneID" id="87860763"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19497" checksum="13FC617B512BE1D2" modified="2024-05-29" version="1">MTDIMAQPIATEGSPSVPELQQPFVSKWASRYRGATVEDLDPPAALSLNPSDPISLALLSAFEREYTHLTIIDSQTRALLGYISIPQLQARLERGEVKPEDEVRTAMMRFRRRGGAKYQVITMETPLEELEAFFAGVATAGQKQDFAVITDENRRFVLGVATVADLEEFVKRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J163</accession>
    <name>A0AAE0J163_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_553365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677213.1">
        <property type="nucleotide sequence ID" value="XM_062829956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J163"/>
    <dbReference type="GeneID" id="87867110"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3335047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="421" mass="45366" checksum="3D67424DCCBB48FD" modified="2024-05-29" version="1">MSSQIRLHDYVPFAPIYPDDGLEFPYNGAARVHISKAGGTTAVAVTRPMTMEMTTNTNCGDASTGQPVFGLTLAAVVTSHPAYVVDEEGWELYDPAALVDVPIEHDDEQQQQPVPSLPAPVPVPPPVSGPPFSAPVNPGRGRFRRSPTPQPDPRLALWRQERRRFAGNVTIETHHPAVKRAKAAVHRPLQTPDGVPQLSFFVDGSMGDRQFVSPAVQSPEGERYQQQDVEHPAGESGGVRAKDFTIGSWSSEKVFSPDMAEMAALAQAMCMSVNFLDSPDPSKKPTVANLEIFSDSRECLGFLQATKAHRAPKELRPIVKAIVWMSHYLKERGSSVQLFWNKRCCALGPGLADAAAGAWRDNRGHIYYSQGHVDLPQGLACTHTTTTPSTSALTTTSPTAAFTTTKSSTAAAMSAVASPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6R7</accession>
    <name>A0AAE0J6R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_552467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677408.1">
        <property type="nucleotide sequence ID" value="XM_062829892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6R7"/>
    <dbReference type="GeneID" id="87867046"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3337957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="361" mass="39112" checksum="B26041C04EF6297A" modified="2024-05-29" version="1">MSGEMANEVKLISGRSHPELSEKVAKRYACLPALDYSALSNKSDIAHCAVVQQQSLTRLVFVCRRLGIEVARTISLNYSNQETSFTVGESVRDEDVFIIQSTATGDVNEGLMELLIAISACRTASARRITAVIPNFPYARQDKKDKSRAPISARLVANMLQTAGANHIVTVDLHASQIQGFFSVPVDNLYAEPSIIRYIRENYKPEDTVIVSPDAGGAKRATSIADHLNTGFALIHKERPRPNVVGRMTLVGNVEDKIAILVDDMADTCGTLVKAASVLKENGAKAVLALVTHGILSGNAIENLNASVLEALICTNTVPLGDKIERCPKIRVIDISPTIAEAIRRTHNGESVSYLFNHAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6S3</accession>
    <name>A0AAE0J6S3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase DHX8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_310167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677457.1">
        <property type="nucleotide sequence ID" value="XM_062823283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6S3"/>
    <dbReference type="GeneID" id="87860437"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29987" checksum="97524B270891618C" modified="2024-05-29" version="1">MSFPNLPPKPPTRQIRALQDQDGATITVYQAYPSTIATAAVAHQRLDASPDFRTTRMTWIKPSWAWMLYRSGHSYKDPGQERILAIKMKREDFLGLLGKGVLTHVTTSTATASPRSGSRQKQQQQEEMTSDSQGGTNTETEKKASKKISRESKRKDRLQSLNVKIQWDPERTVRLDSLNYRSIQIGIPAGLIKEWAENMIVSIEDVTNKARELKRILDERPDVIDEELAELGLVPKETEFEVPVELRSRLGMSHDAPGLVTRTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6X1</accession>
    <name>A0AAE0J6X1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_434129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677532.1">
        <property type="nucleotide sequence ID" value="XM_062825113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862267"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="566"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1659"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2724"/>
            <end position="2799"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3829"/>
            <end position="3902"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4930"/>
            <end position="5006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3405"/>
            <end position="3424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="3408"/>
            <end position="3424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3338081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="5490" mass="601725" checksum="C401D98E159B4C13" modified="2024-05-29" version="1">[encoded data, 5490 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6Z3</accession>
    <name>A0AAE0J6Z3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_477643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677515.1">
        <property type="nucleotide sequence ID" value="XM_062827436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6Z3"/>
    <dbReference type="GeneID" id="87864590"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="5656" checksum="AC7F926AF2015681" modified="2024-05-29" version="1">MANLAFTWNSQGRHEDALALMQDCVEARQRVLGPEHPDTLSSLATVSKWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7E0</accession>
    <name>A0AAE0J7E0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase family 76-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_435547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677368.1">
        <property type="nucleotide sequence ID" value="XM_062825195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7E0"/>
    <dbReference type="GeneID" id="87862349"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3337917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="404" mass="44330" checksum="1B68998CAD2154FB" modified="2024-05-29" version="1">MVAIQWGALAARALFFTSTHPHQHAVDNSAYPKNAQDAAKALQEWYDQPSGLWKTTGWWNSANCLTVLGDLALADDAVGQAIGIKDIFQNTFYNAQKTVATADKLLGKTGMFISTYKYEEHKHKSSRKRKAQGFPKFLNNFYDDEGWWGLALVRGWDATGDAAMLTAAQTIFDDMAENGIDSTCGGGIWWSKDKKYKNAIANELFIALGASLASRVPLRKDSYIRQTVKNWNWFKQSGMINDKGLINDGLKITDKGCVNNGMQTWSYNQGVILGGLVELSKVTGDQSFLAEAVTIANAALKALQDEKGIIREIDRCEPNCGDDGSQFKGIFVRNLAYLHKVAPHDNFRDAILKNADSIWAHNRNSKNQLGINWAGPAEAGKGPTAATHSSAMDVLVGALAAIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7Y0</accession>
    <name>A0AAE0J7Y0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_327551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678038.1">
        <property type="nucleotide sequence ID" value="XM_062823487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7Y0"/>
    <dbReference type="GeneID" id="87860641"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="64"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="569" mass="61834" checksum="1A11EDD880666E3D" modified="2024-05-29" version="1">MAARASTPPAPASPSSGSSAAGTPPGSATKNEFTKEQFAVDDDAPSFAEQNAGPELKRRLKSRHLQMIAIGGTIGTGLFIGSGSALAKSGPGGILIAYCFIASIVYSIMMSLGEMATYIPVTGGFTTYAARFVDRSLGFSMSWIYWFSWAITFALELVATGLIIQYWNDSLSIGIFIAIFWVVIFIINMFPVSWYGEAEFWMSSIKVITVIGFLIFGICINAGAGQLGYIGFKYWHEPGAFAPYIVDPSRPVAKWVGFWSVMIQAGFSFQGTELVGIAAGETEDPRRNVPRAIRMTFYRIFLFFIMTVFFIGILIPYDNKDLNNSGYTAAASPFVIAAQLAGVKVLPDIINAVLLTVVLSAANSNVYSGSRILVSLANDGMAPKWFKLTTKQGVPWVAVIFTSVFGFLGFLNLSENGSQAFNWLLNISGVAGFIAWSGILIAHLRFMKGLEAQNIPRAKLPYTAALAPYYAYYALFFCVLITLTQGFTAFMPWSTEGFFVAYISLILFAVMYLGHKLFTLIVHGAAACKPVAAKDMDLTTGSLDLDVEIIDEVEEPTSIWKKIGTGIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8A5</accession>
    <name>A0AAE0J8A5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_552847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677833.1">
        <property type="nucleotide sequence ID" value="XM_062829922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8A5"/>
    <dbReference type="GeneID" id="87867076"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="125" mass="13086" checksum="40519B6394FFCCAC" modified="2024-05-29" version="1">MSASTNFNFPSHPTSRSHAMQIVEGTRALQQSPALASSTSKSSSAKNNYAESTTSTSSFSSRTSLLKDKFRSSFGSSSSSSPSSSDSSNSNTKSSVSSNSKPSKPMTSTSQQGLFLLGSQIRMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8Z5</accession>
    <name>A0AAE0J8Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_500269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678564.1">
        <property type="nucleotide sequence ID" value="XM_062827831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8Z5"/>
    <dbReference type="GeneID" id="87864985"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="597" mass="66585" checksum="6A20DF1648E4FDC3" modified="2024-05-29" version="1">MEPQVPFEDYARPRPLRTYSHKARTASASVLPLLRTRDLPASLARKHQREPEPQDKNRQDNGSIPEEETIAYQAEYDFEDAHELEFEPQYASDTSQSPDDYATEEVASLEYSTDEDENERTTPEESKSTPPSSVKSSSSTKYISKTVTDQSNRLRRRPFLLFDKLPPRGFKRLKPKAEDSNTSTLSAKYKLGDGFSKDEAKPNGLVQLGLRPTAKRKAPQVESKVGALDLTQYSFTRSPKKDPTANQNKKVTKKRVYDNSFLPDPKRVERQRKRHKLLKKKDNPLEDKEMLPPTTASTPKIILTSAILGEYAKLAERRPHAAAVALSQQQKQTQNEGESGLKEVDMPPYQDDNEEGNIDFEEPIAREPSVELGESPARKEVVAHSAFNHQEECQQQKATPGDHQEDTVEVLSEEAVEQPVTEPVKGPVLLEQPLENPSERTVKKLVEEQAQPANHVQTGESHPRPVTIKESASASDSVKSKSSFEPSQRGLEKHSIHTTTEPPKLTSHDDSPGESHHHQSQGSHEDQDQDHEKIQDAPPSEETSPGSGWETYVSETDIHTPTPPRPLNSRAKSAVPSVPSTSRGPGTSGLRRSNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J999</accession>
    <name>A0AAE0J999_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_297483</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678700.1">
        <property type="nucleotide sequence ID" value="XM_062823105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J999"/>
    <dbReference type="GeneID" id="87860259"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3339340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="421" mass="47025" checksum="651332172ACE3D39" modified="2024-05-29" version="1">MASMALRLPTSQLCKAARPSSFRPSLRCAQQQMRWLATPTTHPVTQKNVGTAMVFLNMGGPSTLDEVGDFLSRLFADADLIPLGRLQNYLGPLISKRRTPKIQKQYDAIGGGSPIRKWSEYQCEEMCKILDQISPETAPHKPYVAFRYANPLTEEMYKKLLADGFGNGRGGRAVAFTQYPQYSCSTTGSSLNELWKWRQRLEGKAGPSEDGKDGTIRWSVIDRWPTHPGLVEAFARNIEEKLAEYPEERRKDVVLLFSAHSLPMSVINRGDPYPQEIGATVQAVMQRLNFSNPYRLCYQSQVGPQPWLGPQTQTSVEEYIHKGQKDLVLIPIAFTSDHIETLYELDQEVIGESGHPDTVKRVESLNGNPVFIKALADLAKEHLDSGLACSHQNSLRCPGCKSERCAASKKFFAGQEILPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9M9</accession>
    <name>A0AAE0J9M9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_511678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678840.1">
        <property type="nucleotide sequence ID" value="XM_062828508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9M9"/>
    <dbReference type="GeneID" id="87865662"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="13">
        <location>
            <begin position="547"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3339480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="779" mass="86686" checksum="DB94B1E3E4CB22BC" modified="2024-05-29" version="1">MGTPFISLVVIPILSVLGWYVISWATSPLKKYPGPPLAAFTNWWRLYHAWTGRYHDVIYEQHKKYGPVVRIGPNTLDLDYPELIKTIYGTDNKWLKTEFYHNNSAIVNGKITYHMFSTTDPAEHTRMKKPIAKYYSTSYVQALEPHVDVVLNDFCKYVEERFIDVPGGPKELDFGEWLGYHAWDLISSVVFSRRFGYMEHGGDFDGTIEKMEQSLRYFQTVGQIPILDYFLDKNPVKRVGPPNLVHPARIAVESFVARVQGKDENYDPKHPDYLQHFIDSKETHPDLVDDGAIISAVLVNLLAGADTTAISLRAVFYYMLKNPSVYNKVSEEIQAAGFDRSKPVPYSGARQLPYLEACVREALRIHPAAAILLERYVPAGGITLPDGSFVPAGTAVGLNPWVVSRNKSIFGEDTDTFRPERWLQQSGEDDEAFHVRMQKYNAADLTFGNGSRICAGKNFALFELYKVCATLLHRFEIELADPAKEWQVSGSWFTFQKDVIAKMKAIEHNKSPRTLHRNDEAHLFLDCFARSGDGNTNAHPRQTTGGSGGTVTTVSTLAQFTAAVSEKNTAPAIVVIKGVISGNEKVRVASNKTIIGLPGAGFNGVGLHFRRQSNLILRNIVSSFVEADNGDGLTIEASSNVWVDHCEFYSDLVSDKDFYDGLVDVSHGSEWVTISHDSNGSQDRGHLHITYANNYWKNCGSRGPLVRFGTAHIYNSYYENKYSKQVGYAVEIDNDFGGASNTAPSGTLTANSPPYSYSLLGSSNVAATVPKQAGAILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9S8</accession>
    <name>A0AAE0J9S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_285747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678322.1">
        <property type="nucleotide sequence ID" value="XM_062822943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9S8"/>
    <dbReference type="GeneID" id="87860097"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="154" mass="17146" checksum="1A7F52A0B1D2D5D8" modified="2024-05-29" version="1">MQGRVGNRKPPSEDEGDDNEDDDSALDGHTAWSPKLHRARVTEMSSVSTLSARNTTESRPSQTPAHASRASSDQGTRSTRISLPIARSHKQTSRLNRNHSSSDQDEEEDDIDLFSRIRSRRAGQRRRPGSPVIKTEVKTEDSQSATSLHEIPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9T8</accession>
    <name>A0AAE0J9T8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_511754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678930.1">
        <property type="nucleotide sequence ID" value="XM_062828518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9T8"/>
    <dbReference type="GeneID" id="87865672"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="243" mass="25291" checksum="94CCB8E02CD9FB60" modified="2024-05-29" version="1">MTERKIPPSNVPDDKVPRESSKGEPTKDLETSAREVPAEPDTSSTNDPQNGQPQPDDDSLEKIRWAKEWIKQNPKAAAALGLTAGGLTVVAAPALLTGPVLSFMGFGSSGVVGGSIAAGIQGMIGNVVAGSWFATATSAAMGGYGVPVVAAVGQGVGAAAAFVGGAYATKELRKEQAGEEEEAKDEDGEVPEDPKDGDDEDGAVTEKEKASRWRQSGLGRRDFDDESTLLDNSDSENSDDNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAN9</accession>
    <name>A0AAE0JAN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YL1 nuclear protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_471526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679111.1">
        <property type="nucleotide sequence ID" value="XM_062827106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAN9"/>
    <dbReference type="GeneID" id="87864260"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="718"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="920"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="968"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1055" mass="113419" checksum="4B0BAC7FB50EC228" modified="2024-05-29" version="1">MTTLDLNLDPKHKHPDLPLPKEINEEDWSDSSDDSDVETANDGEVAKQPQQQVEWLATSRAKRSTAGNRMKSMLANEEPAAEDSDLELLFAEDEDDAGFTDEDKDDASDVQMDSSSDDEDDKEGAAADDLEGEKELERQAREKRNAQRKRKAQEAIPMKFRKKVRIEQPPSATGESAAGSPAPSTTGTPAASSVRQGPTPRPPRPKKKSERTSWLPTPADMPTRASERRTTKMSKEQLHQKMIDDEIRRKKLMEKMEKNAKRLEALKKPPMTQAERLAEAALVEKRNEKSLNRWEEAEKVREEERLRKIAALNNRKLDGPVVTFWSGIQTLEEGQQKHVGKMVSMEEKPVRKKRQSVSATLAAQEAAEKEKAKAEEASKQPPSTEQGDIQPTEATTKQDNKAEAQVEKTDPSTALPEQPKEPMSTQDVVMKDAPEQPQQTQPPQPPQPPTLAPIRGPMAPPPIPPPPPMETKTTPSSGVLAAPVLAPPAGVAPPMLDAQMPGLAFPFSNGMSNVLAPPNTTSPLSMPPSSGGLSTPAPPPAPAPPLISAPVTTSAPTTTLTFAPTHIPASAPDVDLPPRDTSSPATTVITATIQTKQAPTPPSSQPATLSPEKTNKENKPAVPQKNDKGEGGGKGEESNKEKKSENAEKGPDGPQEGSTVPTDQPAAEGVEGKTVNKVTRSCIILQNFDEAAIKDKQVQTQIIFGRRMEKLAKPAHSPLCVVTGHPARYRDPKTGLPYYNAYAYREIQRVHRGDYKFSALLGAYVGSVTYAAKGVPERFLNPNGKRSTPKEDPAKLAKLKEAQEAEKEKEKQASEKAKEVEAGDKKLDNVQATELPPLREPKVPHLPRRASGTEVTTTKARSKSTSKETTIPSELKGKSSTSSLPATMTGPVVQAKLEPIDDVALPPTKAASAPAPPTSKPTAATTTTAKPSPQLSTPTPPLQTQAQFKLVDDAETRQQRQQPPPAESTSSSNSQSTKTPKASQPQGQSSQAPAPTQNSAAVAAFAPAPASTKPAGPVEPSKPTKPAEPVEPPQPPQAPPVADARFQPAPVPDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBS7</accession>
    <name>A0AAE0JBS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial ribosomal protein L27-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_467810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680084.1">
        <property type="nucleotide sequence ID" value="XM_062826925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBS7"/>
    <dbReference type="GeneID" id="87864079"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3342291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="103" mass="11806" checksum="043F2A167C5D884A" modified="2024-05-29" version="1">MQPTRVLQGLKYRKLRLTTKDVNKGFYKGNRTGSMGTHTSYGTYKIDYSKVRTYVCPDLTGFKLTPFVSKTIRPVHDQFPGDKLGPRNPTTYLARWKSENGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC41</accession>
    <name>A0AAE0JC41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nuclear transport factor 2</fullName>
            <shortName evidence="4">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_509544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680232.1">
        <property type="nucleotide sequence ID" value="XM_062828324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC41"/>
    <dbReference type="GeneID" id="87865478"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3342439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="123" mass="13726" checksum="208E4C66F8471910" modified="2024-05-29" version="1">MTDFASVAKQFVTHYYATFDADRKNLAGLYRENSMLTFEGAQSLGVQGITEKLISLPFQKVKHEYGEPDAQPTANGGIIILVTGQLVVDDEQRPLGYSQAFQLCQDASANWFVFNDIFKLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC73</accession>
    <name>A0AAE0JC73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_468379</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680275.1">
        <property type="nucleotide sequence ID" value="XM_062826957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC73"/>
    <dbReference type="GeneID" id="87864111"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="15">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="16">
        <location>
            <begin position="298"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3342482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="419" mass="43644" checksum="13F3407809FF8FAB" modified="2024-05-29" version="1">MGALDRLSQIGNQISAGVTGGGRDKILQKNADDIVVTCALRTPFTKGGKGGFKDTHGADLMAGALRGLIERSKIDPALVEDIKVGTVLAPGGGATEMRAAALVAGFPESTAVHTLNRQCSSGLQACVDIANAIRAGMIEVGVGAGVESMSTNYGPQAVAEFSDLLESHTEAANCKVPMGVLSEDMAKDKGVSRKDQDAFAASSFQKAVKAQKEGLFKEEILPLKAKFEDPKSGETKEILVDRDDGVRDGVTAESLGKIRAAFAKDGSIHAGNASQVSDGAAAVLLMKRSTAEKLGQPILGKFVAASVVGVKPLLMGIGPWKAIPKVFELTGINKDDVDIFEINEAFASQCLWCANELGIPMEKINPKGGAIAFGHPLGCTGARQVSTLLYELRRTGKKVGVTSMCVGTGMGMAAVWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC88</accession>
    <name>A0AAE0JC88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_549679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680265.1">
        <property type="nucleotide sequence ID" value="XM_062829673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC88"/>
    <dbReference type="GeneID" id="87866827"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3342472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="311" mass="33265" checksum="9F2CAB37A24BE626" modified="2024-05-29" version="1">MRATLSRLLQATRVLQHENPLGLPRTGTIPRFQRGLPQKRKIKNVNKVIAVSSAKGGVGKSTIAANLALSLSRLGYTTGILDTDLFGPSIPTLFNLSSDKNPHLSPSLNANDQLLPLTSYGVKTMSIGYLLGSEDSALVWRGPMLLKAIQQLLHEVDWSHPSLDILVLDLPPGTGDTQLSIAQQVVVDGAVIVTTPHTLAIKDAVKGVNMFRKVEIPILGVVQNMSVFCCPECGKETHVFGGTEGVRKVCGEMGMEFLGDVPLHPAIGEDGGRGKPTVVSDPGGREAEVFMGLGRRVAELVGLEKMPLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCA6</accession>
    <name>A0AAE0JCA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_222850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680337.1">
        <property type="nucleotide sequence ID" value="XM_062822075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCA6"/>
    <dbReference type="GeneID" id="87859229"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12160">
        <property type="entry name" value="2-Hacid_dh_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="57"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="126"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3342544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="337" mass="37001" checksum="F6EC9E125A41490C" modified="2024-05-29" version="1">MRSTPTRFLSRINSHLSASSSKMKLLYPTSLKLDVSQIEGFPSVTLHPYDVKAPIPEEHVDAEVLVTWTNSSDNLKDAVNRLTKLRWIQSLAAGPNDVLSAGFDTSKVAVTTGSGLHDRTVAEHALGLLLNAARRFYEMRDFQLQGKWPGHLGGPQPDRPSDRFTTLRDARVLIWGFGNIAKTLTPSLVQLGSQVRGVARRQGVRDGIEVYSEDKLAELLPQTDALVMILPGDPSTKHALNAERLKLLPKHAWVVNVGRGTSIDEDALYDALVEERIGGAALDVFETEPLPEPSKLWKAPNLILSPHAAGGRPQGAEQLIVENLRKFLAGQQLKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCQ9</accession>
    <name>A0AAE0JCQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_575985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680408.1">
        <property type="nucleotide sequence ID" value="XM_062830642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCQ9"/>
    <dbReference type="GeneID" id="87867796"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042084719" description="Glucosidase 2 subunit beta" evidence="7">
        <location>
            <begin position="21"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="438"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="170"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3342615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="565" mass="62620" checksum="6DF6C75761EDFF19" modified="2024-05-29" version="1">MRRTAALVLLSTIAPTGTIAATESVPRGVGPEFAKFYSNKETFTCISNPSIVLSSSQVNDNSCDCPDGSDEPGTSACSHLDPLSPEQPLPGSVTGTTNTTRALPGFWCENKGHIGAYIPFMYVNDGVCDHELCCDGTDEALHVGGTRCENRCASIGKEYRRIEEERRQSKERSAKRRRTLVKEARELRRRVESKVASLKEELANLEVQKAELQKKYDEVERAERGKVVKAEGEGGKLGVLVGLAKKRVDELRDTLDKVLDQRDDLQDRVDQLEDILSKLKEEYNPNFNDEGVKAAVQGYENYAAGKSTEKKSEVVDADVLEVLKEDGPDSGINWAEFREEETSDADIVYNLEAYLPPSVRSFVHSKISSLKVWLIENGILADNPTTGGPTESKLVMAARDALEAARAEHTTKSSQLADEERDLAKDYGPDDIFRALKGQCVSADVGEYEYELCWFDRTTQKSKKGHGNTNMGNFERITTEVADEEDRVDGKGLGKGPRMVLRFENGQGCWNGPQRRTDVWLACAEKDELWRVSESEKCVYRMEVGTPAACEEVGEPGVGTKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD08</accession>
    <name>A0AAE0JD08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_468587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680336.1">
        <property type="nucleotide sequence ID" value="XM_062826965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD08"/>
    <dbReference type="GeneID" id="87864119"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="692" mass="75025" checksum="F0B53E4EB0153C5C" modified="2024-05-29" version="1">MGAYTSVPQCLAHYGVTINCSVVYAPDNQTVISVGGNRPGDFNPDPDIAGIGIIGAFVVTTGFSLFIAFLHVLWHYAKLTKLKRRITEEEKENKRWQLSIGGFFEMLVISCSDQQIFTGAAYAITMRFAKACSISAYHYNIISNMLLITCATHLLTLLVSKHYWEHPWVAAIRTVATALLYLATGILLSTQAAPGSELAFPTQVPKDNEKWSTLLLPAACFQGSAAQFGNTLEQSFHGAGLFKVGDRITGWTPFVILVLYYVLANIVTLGRVVRAGRENGGKREKFCKWLVELIGQKKLKWVHRIGGQVYGVYLLAGLVISAYTMVSSSEYIEMLRRWVDRSGWIQLYLGTNPENDPKSFGQLVPLLMMTLTVFTFLQMLSEAITIRKLKNKQSEEIEDLQEQLDEARNSSDRLEDGNNGNGKQPGVHEKETFSRQSEASGSQAYGMNSQTPWSPAPMYTMFANPSSSSNAPFFVQAAPTGSPMATPAWASMTPQQVTPSHFIIPAQFVYGAFPMTSPGNGSVPPSQGFPWNPSTPFGPGPAPASNAPGPSKPSPSDDSPSQPEPLSKAEPEITTKDTKSTPVVSVYESSTSSPPSRSSTVPDNEKLAPHPANLLRADTDFTLIGQPSSSLDAGGQTDQQMPAQGFNGVAADPNTLSYFPEVAIAESSVEEEGQEAERNTAGGTGFEVGKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD30</accession>
    <name>A0AAE0JD30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_235306</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680759.1">
        <property type="nucleotide sequence ID" value="XM_062822250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD30"/>
    <dbReference type="GeneID" id="87859404"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="673"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="211"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="428"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="590"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3342966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="953" mass="103928" checksum="9D48EEAFCB5DFCD2" modified="2024-05-29" version="1">MDGQLSLLSPTSSSSTSHRKRLTKKQRPPSTNHRTSSSFNVESLRIDAQSLDSKRSSSSLRRGPSSSQNPSLARTVSVPVSVPSNAPANAKASNLSLPRSHTTRSQSANCPYNPTQTIPTNGFILSPTSSSQPQYQSQHYPSAAANTTVTSSRNKDTSKQYDPLDSCIGSFDQNKSSTDELIGAPFDGKAILNRIEATKLSAAPAPTTTTTIAHFNNISPRRIAPPPPPLPLSRSNTDSKAVRSSKPSKSPKSTTSNKTMGASSFRHSASFSSAEQLPPSEKPSKSESSSSSNKRHSGDGKESRVPGMLRKKSGFSGFMNSLVGSPKKPLISAPENPVHVTHVGYDSNTGQFTGLPKEWQRLISESGITEKDRREHPQILVDVLTFYKETTEKPQEDQQLEKFHDARATDFRSPPVTGTTPLVLQTGGGYTHGPMSPMISPPASPRFPQVGHEGSFENPRAPPPVPKGPGPLPAKDINLIPSRPAPKPPANISTRPLVPPTSYPAKDSGIGMPPPGDEPPMPYLPPKDNVQHMYQEEHRNRSRSNSRTNGAAPFSPVQASSPLLPIAAANQTAAYQQQLLQHQQEQAMAQAQAAMSGQLSRAASKRQQPTPPTSQHQHPRQPDVNGAPRMPQAQAAVPQASARPRHRPRQSNAIDVVASLKRICSDGDPREIYRGFTKIGQGASGGVYTGHERGSNRLVAIKQMNLEQQPKKDLIINEILVMKESSHPNIVNFIDSYLCAGELWVVMEYMEGGSLTDVVTFNIMTEGQIASVCRETLRGLQHLHSKGVIHRDIKSDNILLSMEGNIKLTDFGFCATINEAQSKRTTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALWLIATNGTPHIKDEQSLSPVFRDFLYFALKVDPEKRASAHDLLRHDFMNKCVDLSTLAPLVRAAREARAQEKARKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDM6</accession>
    <name>A0AAE0JDM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_589585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680347.1">
        <property type="nucleotide sequence ID" value="XM_062831040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDM6"/>
    <dbReference type="GeneID" id="87868194"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="439" mass="48262" checksum="40AC890E3D12CEE2" modified="2024-05-29" version="1">MPPPLSQRSDESSSEEEASDSGSVHEAAPESDSLQLLRESAMGVLASRLTAQNSGTSGNHVTGKLINNAKRGPADDLTNDHVAKYPRLDQGKEVQDEEESDEEEEYSSSEEDEEDEEEDEEGQGSGSYPSHSASGRFVVSEGISPWTPRDPSADKYPLHPDLVGMTPVELFPHALPNFKLPHHLAPIARHLAERPIKRMPILEKPFVDNKPDNFSAYFLQATGHMVPDEQACARCKGVVIKKRYVGGTFVGCVVFADPEEAKLTGGACANCWYGRQGSLCSFRNPGAVGKLKKQPKESYEPRSQISNPSLMSPPPPPEGQPMQHGQQLGNTGQVHPAFLASISSASPAYTPSSDYPHIEAQIVHQRNGEAPILPRPDGSVNKVTAWETRYRKMSTDKLRATHGNLVEWQEDLNTRLLAMNKVLLDRLDKREQSYSVPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDS2</accession>
    <name>A0AAE0JDS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinesin-like protein KIF22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_245438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681100.1">
        <property type="nucleotide sequence ID" value="XM_062822388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDS2"/>
    <dbReference type="GeneID" id="87859542"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000072">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="559"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="691"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="698"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3343307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="895" mass="97558" checksum="24AA05840B33A6CD" modified="2024-05-29" version="1">MSVRVVARIRPLLKKELDKDVIVRAASTEEGRPSTIVKIPNPKNETEEFSYIFNSVYDQSCTQEDLFNAEVYPHIKALFQGLDVTIFAYGVTGTGKTHTMRGGMKMVDRGLIPRLLSNVFRRGKKIEKDSNGETIVDVHLSYYEIYNDKVYDLLEPPEMRTPMGLPLREKEGKTFVVGLTERPCDDVTDFERLYVEANNNRVTAATKLNAHSSRSHAILRVKVTQTTGDMVLESTASAIDLAGSEDNRRTDNNRDRLVESAAINKSLFVLSQCIDAISRGDKRIPYRESKMTRILSLGQNNGITIMILNLAPMRSYHLDTLSSLNVSSRAKRIEVREIENEVVYKQPHRSHSSTSFSGLTNGVLAPRQPLRPIGLGTHNSYTGSAPALARSSTDRAAASGAVIEKAEKPSKLFNVYTDRASAHKATASMGGSSRFAGPPQANTSQIRQPLSLSGLTSRRSMTDTATASPSETSALRSGLIGTGPSKLARPTGLPLPGSVSAGVSRQNSSSSGSIQPPQQTSKSVDNTPILTLSAAQIEAMVEKKVAEILAARAAAAAALAPQTPTPSTPKSENHHPPGSEQQKSEPQISEEVQRRLEALERRIEEQSMSTSRSSSRRGRGHSGKDEKSAGLQLLLEARKAKEGGNLEEALGMYEDALGFFPGQRKLVGKIEKLKLKLGKISREEYEVGAQLREEAGSRQGSGVGTQQSRSASVNSGRRTAMTGISSTDPEAEEDDDDMEADVEETPEEAEARRRRLLKSRGRSATLGVGISRSRQQLYSNTTTDHSASDYDDRSPSNSDQEPSPRTKQLLDIVNSRDTELIKSLNGFGQKRAQDLVDHLDETQGPSGKVRSLGELTTVPGVGVRTVERAYEGLAAAAELSSKLALKTYYDETETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDU9</accession>
    <name>A0AAE0JDU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_179395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681162.1">
        <property type="nucleotide sequence ID" value="XM_062821487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDU9"/>
    <dbReference type="GeneID" id="87858641"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="224" mass="23792" checksum="EB768E417447AF75" modified="2024-05-29" version="1">MYRTNHPWWKLTHILCILGHLGLIIAGVVAFIHNLQSEADNLDTTLQQPTTIVMNMSDDQTVINSDTKSCNIVLVQGLGNGVDGKSGSGHSNFGIIVNELLPVASVIVGTIGLILNIGIFAALLAVETTSAKVTLTEGEQHWRKKIVTVSCCVFNLLLAGAGIGLAGAMGIRLSNVGGRQLGMSESERSLIAPLVLGAVQALLCVITALFDFIKNHREGKDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEB7</accession>
    <name>A0AAE0JEB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_573152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830537.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87867691"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
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    </dbReference>
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    </dbReference>
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            <end position="387"/>
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        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="598" mass="67253" checksum="03BF54398A521836" modified="2024-05-29" version="1">MPRLSLICHLPWFKRTGYFKNAEATGHKDKVSSISGHGGTFNIGTSVYAVAPTPCRLLPVSRLDKLRKKSTRRSLATVFLVPASDKGANETVTLDWITNAVENYTASDGVFHISFLETVIFKGGGKKKPRISPKAQKYLFEQGTRDIILWSDAVDLPPGPYYKTGNQMRDVWKLEDDTYGTCMVTVAPKSDPSESFQPLHWIGTRHQFPSFALPSKVQTGDTVDFESKPLAGWRIVVKDNIRLKGTKTSQGNRAYYDVYDASKEIAPCIQKLIDKGAIVVGETKMNSFANWEEPIEYTDYQAPWNPRGDQYQSMGGSSSGSAAAVAAYDWLDIAIGTDTWGSVTRPALWCGCFGLRPTMGAVSGEGIEPLCKEWDTAGLLGRDLQRCIHSAMQWLDMEKMVAEPKPFTSIIWASDFWSIIDDTQQVNSAREFARRMGSILSVDFDTWAVSPPQEAQGLSLREYIEDAIEVQSYDAYHNFEDFRRRYQEKFGHTPYVSPRNQGMWELAKGMSKEERDRGFHKMGVYRKWFNKTILNGKHFNALVMMPLEKMEPRYRDEVPTFPRPPQGGVNALALGPVMKSPVLAVPSRHIPQLPKKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <organism evidence="3 4">
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681445.1">
        <property type="nucleotide sequence ID" value="XM_062829588.1"/>
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    <dbReference type="GeneID" id="87866742"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="chain" id="PRO_5041991150" evidence="2">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="141" mass="15868" checksum="971FA6418F538B3A" modified="2024-05-29" version="1">MQITQTSFIIAFLAIGAIALPTPGKSDEAWTQIINKRGNEESWTQKFGGRAEEAWIVDPPTPAKRADEESWTQQIGKRSDPEAWTQQIGKRSDPEAWTQIINPTTKRANDEAWTQIINPTEPTAKRANDEAWTQIINNPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEI8</accession>
    <name>A0AAE0JEI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_185948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681414.1">
        <property type="nucleotide sequence ID" value="XM_062821572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEI8"/>
    <dbReference type="GeneID" id="87858726"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="217" mass="24250" checksum="F51CE9EDFF3DE86E" modified="2024-05-29" version="1">MNGKINVHGHFRHDQWKIPWYGYLHFVKYNTVLTAPVMEILGVSAGFCACRQWAPVDGKPPSCGQPQTRWQGSKHTASPACSFRRPVVTPPPSRRPPAKRHQQLPVSGVVWCRGPPGRDRGLHLVGAGPLLAGESSKTVVCERQQLSCPAHPPSAKQQNKLTTTRSILRKQQFLLPFSFFYLSIITTERDHPNTSRTPLVSPPRIISRAKQPRKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF63</accession>
    <name>A0AAE0JF63_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_426132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681481.1">
        <property type="nucleotide sequence ID" value="XM_062824615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF63"/>
    <dbReference type="GeneID" id="87861769"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="49"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3344868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="358" mass="39967" checksum="F306D8A9BD3BF417" modified="2024-05-29" version="1">MPEATTSGADASNGSSAHNRQHNQGNQDRKYTVEQKAAVLRIRKCEPTAFYEILEVSKTCTDAEIKKAYRKQSLLTHPDKNGHEHADEAFKMVARAFSVLGDKEKRDKYDRFGTDPDSRFASAQQQNPFAGFANRGAARAHQGGMWGEDADISPEEMFARFFGGGGFGGGPFGAAFDGGPQFVFNFGGGPGIRVHQFGGGRPRTRPRQAGQQQEGNSMWSTLMSLLPIIVLFIFPMISSLFSGATSGPSTPSMSFEQAKPPYTMARKMPNVKVNYYVNPNDVRHYSASKLYNLDQKAEVIFVQQLQQQCEREMEEKRRLIEEAQGWFRTDQEKLAKAERFETPACIRIKTLYSPGSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFC3</accession>
    <name>A0AAE0JFC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FGGY family of carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_574101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681864.1">
        <property type="nucleotide sequence ID" value="XM_062830568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFC3"/>
    <dbReference type="GeneID" id="87867722"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="5">
        <location>
            <begin position="313"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="598" mass="64902" checksum="0E6E75163360C367" modified="2024-05-29" version="1">MSSSQNHYIGIDVGTGSARACIIDSTGDIKALAAQNIKLWTPSSGYEGSHYEQSTTDIWNAICYCVKQVLAESKVDPNSVKGIGFDATCSLAVFTHDTNEPVPVTGPDFKNDGNDRNVILWLDHRPLAEADKINNTNHNLLRYVGGKMSVEMEIPKVLWLKNNMPPELFARCKFFDLTDALTYLATGKETRSFCSTVCKQGFVPVGVDGSVKGWQEDFYETIGLGDLVKDNFMRMGGVDGVNGSWMSAGELVGGLSEEAAQQLGLPAGIAIGSGVIDAYAGWIGTVGAKVKLSPDALDDSVAPNDVSQAFTRLAAVAGTSTCHLAMSKGPVFVPGVWGPYRDVLIPGYWMAEGGQSATGELMKHMLETHVAYDETLKEAEAAGKNIYDYLNEHLKEMAKKTNAPSISYLVRHFFFYGDLWGNRSPIADPNMRGAIIGMSNDKSKDGMALLYYSTMEFIALQTRQIVEAMNAAGHTIKSIFMSGSQCQNEILMDLIATACDMPVLIPRYVNAAVVHGAAMLGAKAASAKPDGTTEPLWDIMDRMSKPGKTVWSRGDPAEKKLLDAKYEIFLDQARTQQEYRKKVDAALKGSSLEGQEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFI0</accession>
    <name>A0AAE0JFI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_494412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682035.1">
        <property type="nucleotide sequence ID" value="XM_062827775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFI0"/>
    <dbReference type="GeneID" id="87864929"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="325" mass="35610" checksum="5C29241B67F854B5" modified="2024-05-29" version="1">MHVIPLLPIRTAALRVRLDFRPRKGALTLRPHSVSVRTTATTTTTIPNSRPRVVHQAPPPYCSSSPINHHRRPFTTETTTTTALLVTMSDVQAAMPSMVVLSTSMISLITGFVLGVYAIRGYLIPPEMKEERRRYFEDPVESEESDVDEDDLILDHAPNWANGLEADQRQGLRARGAAAASFSGEKKKKEKAPKVGLDPTEECKLVLVVRTDLGMTKGKIAAQCSHATLACYKRLFSAAQLEPMSLSARLLRQWERNGQAKIAVQTKSEDEMLELMAKARSLGVTAEVIQDAGRTQIASGSRTVLGIGPAPKSLVDQITGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFK8</accession>
    <name>A0AAE0JFK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_204090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681984.1">
        <property type="nucleotide sequence ID" value="XM_062821840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFK8"/>
    <dbReference type="SMR" id="A0AAE0JFK8"/>
    <dbReference type="GeneID" id="87858994"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="145" mass="15910" checksum="BE5E4C8AEF5732E4" modified="2024-05-29" version="1">MSGGKPRGLNAARKLRNNRREQRWSDLHYKKRALGTAFKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFY5</accession>
    <name>A0AAE0JFY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAPA-1-like conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_204615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682003.1">
        <property type="nucleotide sequence ID" value="XM_062821851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFY5"/>
    <dbReference type="GeneID" id="87859005"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="320"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="425" mass="46622" checksum="A91E93A2358AB67B" modified="2024-05-29" version="1">MSSRPRRSAAQRATALITDLIHSDRVTPERTMSSSRSTTARRPPSSPASSRSDANGHNMLTVKVPSNKLREATSGNSSSGIAASRRNRPGAKKSYVVESSEDEDEEMEEEEDDEEVEEADEIEVSNNAPVLDDDEDDEEDEEEEDDEDEDMDVDEDDDVDMDDTPAPPTITVSKAQATTSPNKAKATAKAPSSSPTTIKAAPKTNYYDDDDDDDELSELESEPEDPELEDMAAAEDDAEEAEEEEDEDMDAEGDEIEVAEDDAEAEEVELDSDEEGGSRGGTPDISKMTARQRAKVGVASHEYMKLSDEVQAKKVFTAEELSMRRAEMARRRRNLSEKRNEEVKMETINKLLKKQAPKTNRKAALLNGDETPAGDAGPPKADPTFVRWINNKSGSRIAVPEDMLAGPVGQVFTGGVKRKMVEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG06</accession>
    <name>A0AAE0JG06_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_205990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682048.1">
        <property type="nucleotide sequence ID" value="XM_062821865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG06"/>
    <dbReference type="GeneID" id="87859019"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="478" mass="52986" checksum="FDC00E9E8B2CB8FD" modified="2024-05-29" version="1">MDAAYNQHSHAARRKNRSSTNLNHLSLAPLTSKLPIDNDDFLEQYQQQFEHVSHSTSYLQGKSAPSTPRLISHSPGPHPARVATMTGTGMNHSRGKSAPAAGLPKSKSTTHLGSKSGAASPTHKRRSAAAVAADNERNLSDWLLRAGALISTETRESKGQSWLVSRASSTSLTGLHNAEEEAFERELARERELLLQNTAANQIAGIGSRNVSRNASRAASRNASRRGSLVMTTGHSTNIIDDEYYTTSPIHSRLGSRSHSRTGSRTQLARTPNERHAALEHSAGYFHHHGMYNHQHHEVGITEEDDEDNNGPGPDFVNLDEKLELAHYNQQQLLLDNDAAASIVQDEIAVRRLVKDRNIGSWFGRVLGVQLFAVEEDDEEDSSDSDRDDDDDDQLAYGSRQHSEGQLTEDDDGSTTETDSSSEDRRRRPHDNQRREQRRFEDAQLSKLVDERVPPPKEEGGTWHDAAWLLTVASKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH56</accession>
    <name>A0AAE0JH56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA ligase</fullName>
            <ecNumber evidence="7">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_155823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682870.1">
        <property type="nucleotide sequence ID" value="XM_062821158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH56"/>
    <dbReference type="GeneID" id="87858312"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000018">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="10">
        <location>
            <begin position="542"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="649"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="882"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="132"/>
            <end position="147"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="651"/>
            <end position="665"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="666"/>
            <end position="676"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00007572"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3347788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="915" mass="100888" checksum="98B9E893041E4BD1" modified="2024-05-29" version="1">MSSPAKKRKLNSGAKQSSSVPSRGLEYFFAKQKQNGASKEPSPLQKESDSQPTQKGPSEEQLSDEELARKLQAEWDAEAKASTPRENKVRPHDVPVPETGFVDTVAVEPTKESKPQTVTSPSKALPKGKNTLSLSSEAAAEDQASASIPLDESPLTFDPAKYIPQLQDSWAIDGGDASYALLTRCFVLVSSTSSRIKIVDTLVNCIRLLIEADPSSLLPAVWLATNAISPPYVSMELGLGGSAISKALKQVCGLDNRSLKTLYDKLGDPGDVAFEAKKKQSFTLRKPKPLTIKGVFQSLVKIAKTQGQGSGDVKQRIVDKLLQDARGGEESRYVVRTLCQHLRIGAVKTTMLIALARAFSLSKTPGADFPTKDPNQLAKLRKEELAEVYLKAEEIVKASYARHPDYNDLVPVLLEIGVCEELLVRCGLTLHIPLRPMLGGITRDLSEMLSRLQRREFACEYKYDGQRAQIHCDEKGVVSIFSRHLELMTDKYPDLVALVPKIRGEDVQSFIMEGEVVAVDRATGELKTFQTLTNRARKDVAIGSITIDVCLFAFDLMYLNGQPLLDRSFRERRDMLRSLFVEIPHHFTWVKSIDATSQDSETVLEFFKSAVDSKCEGIMVKILDNLPELEAPEPADDAADPGILEEQQLPTSDAAATVSASSIKPPKGKAKAKPKPKPTETTPSDTPPIPEKKLPTRRKPLLATYEPDKRLDSWLKVKKDYIGTSAGVDTLDLIPIAAWHGSGRKAKWWSPILLAVRNEETGSLEAVCKCMSGFTDTFYKANREFYDKDGSFSSDGEPRNVHVAKPGFVEYAGGNPDVWFEPQEVWEVAFADITISPTYTAAIGLVREDKGLSLRFPRFLRKREDKGIEEASTSEFLAGLWRKQEAKAPAPPPVEGGREIDEAGLENEDEDEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHA0</accession>
    <name>A0AAE0JHA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_423733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062824476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861630"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1014"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1313"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1436"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1632"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1686"/>
            <end position="1735"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1756"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1832"/>
            <end position="1880"/>
        </location>
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            <begin position="2024"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="419"/>
            <end position="436"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
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            <begin position="657"/>
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        <location>
            <begin position="815"/>
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            <begin position="1027"/>
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    </feature>
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        </location>
    </feature>
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            <begin position="1712"/>
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    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2044"/>
            <end position="2060"/>
        </location>
    </feature>
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        <location>
            <begin position="2073"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2097"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2133"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
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            <begin position="2164"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2186" mass="234257" checksum="B407EC9C7BBB2B5A" modified="2024-05-29" version="1" fragment="single">LTSYLQGSVNKQISRFEVTAVYTHPQATADIVLVHGLNGHPEKTWTAANGVFWPTDLLPASLELKNQHANVLVYGYNADVYSRGTNTPSNNFIHQHAQSLVTSLTSFRKSEGTERLPIIWVVHSLGGIVTKRALLYSNDIRAHQQEDLRSVFVSTYAIIFLGTPHQGSDLATWGRMLQAMSDAVIPRRFFETESVLLKSLKRDNETLQGINNHFLDIYQRFKIHMVHENHTTDLRGTRALVVDANSASPQLQGVIYYGIEATHSGMCKFDGQNAPGYRNVSTAITEWVAVARTVIDIRWEAEEEERKKRAADEYYERSVQAMQSYRRSHSPGYSNQQFPSIGRFRRSPSSCYGHDHDCGYGRNETLLLQHRPHGQQRPPELLPPLPSSSSRSALSTREPTLVLEPGDISPSQPVDGNNDDPITTITTDIQPQSQPQAPLTPQHPEPLFIHPDSFRPNSFFIGREDELRGLHEMLQDRRRRLEGTSAVLIQCLPGGGKTHLAREYVYRYREHYPGGVYWVRAKSRGEVESGYWRVVRMEIMRDTTENQMGVGVTGVENLREDPKTMVQVVKAWFNSHRDWLLVLDGIQFDIPGLSEFIPDAKHTSIIYTSTERAVTGDPRFDNPQVMELGLLTPRQAVQLLLTELDRASVSTPSNMGNGKGKGGKNAHGGWKDEEEEKRALELVNLMGRLPLMIHVAAQHLKATREPLARYLAGWRASKPKQVGNLHAYKKVREQLDARGNSAALNLVGVLVWWEQLVPVEMVVFGLPALSRDTPVKTCDASHRKTTLNNTLKVLIKFALIERTTESDDSITPLTRSPSAASGSSRTSANRSLDTPGGNYYRIYSDSSDSLDLLRIHSVIQAFFIETLAEEKTAVAWLERAAAVWCRSFDEAHRRIDEARKSVVVGGGGGGGGGEHEGFEVSPRVGVPDDYRRYCIHGQKLLQNIERFGNEKRDPERRLEKWRWMVRQRVEEAGRGVEELSRLDRLGRVGGGVSGEQEGREGRWGQGLEVVSVFDRNSGSRGGSSVSETDSTATTAPSHESQEEGHVGPGSWESAFGGAELDEGFTPMESPSSYHHSTSGGRQRPSNLTMTISGQAALGPFPWREMGMEVTAPYPTEGVMPPTPGLDNKIRNMLEDERTVVPAAVSDYYEPVDEQPLDEVDQAALTPIVETPSVYTALDGLEIPTPALETGLFEEWNAVIPNHRVIKKQEARRYRDRAGSWRDVRTVGDPRVGVTLDVAVGSLAGKPGTSAAGVVPVWPPHRKRRVTAQTQSEAQLELNKIRQKAAGTQAVVAQAQAQAVNEGVSGGLGDNLTLPMPSRKTSGGGLSAASDLSPPTPSSSGLLSPSGWLKRLREGFGSSVQSVPTAVGSTSPSMPLGQQLSQSAPQEDELMIVPGPIFRGSRTSRSSPANHTSSPFPPPSFAATADLDESAVRLPRSAHGFSEPPSQVSWDQDADYLSSSQPVGALPQWDRLPRNTTPGQGLNRQSNVPPPLHPVTGLPYPTVATRPGPSPLMVPGAVPGHVPTGYSSQPMSRDPSHQSSASGVGQSSGGANNHSPSPLSLSMQSVNGFSSSEPMVMGVSKPRPLVSAGKVAAGSSSLGMNNNSSPAVPGTNVNLGNRPSLMQLQMPLMPININAPGSGAGRLSSQKIQQAQQQQHRPASYTETEPSPRMEDAFPDVDTSYSRWEQMHAPGHHQSASSYQSPTAGGHAHKKSTSSTGPGQVTTASSSAPHPQPAPAILWRNLGRGLTRRRTKERIQNVLGANNGRSQSASPSAFPTGSRRGSGQHSGSGQQHPLASSVTSTATVGSAAQSQGYGGSLDLVASISNMGGQFPATPASAASAMPSTSAPPQRPSIGSLYAVASSPVPPPSLQEPRSSSPAVGTGAGAGAGILLSDGTIFQFPSTSSVASPLTPMTMTNVSTGSPIVGPAGREMDVEPDTGVFHGMEEDFNNDLHGFPPPGSPVASGVAWEVQQSSPRPMATPVQGGVMNAGLGAAPGSVVTPPMPPTPPTATGLGIARRKRIVHQLTSGSAPGLRSPNPNTPPLHASLPTLPSGSPLGSVPLPQGTVTSPPIPVPASSTRPVVNPNSPSVRGTRTRTRARSGSSPGPWRPSSMSSMSMGTLHRPWGHGHGAGGTGSASLSRSGSPSLGTIDAGRLSPRQAQHRKEGGTSGDEGAGAGSGGGTGLGILPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHA2</accession>
    <name>A0AAE0JHA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_157867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682945.1">
        <property type="nucleotide sequence ID" value="XM_062821188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHA2"/>
    <dbReference type="GeneID" id="87858342"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="385"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="117668" checksum="636544971529075F" modified="2024-05-29" version="1">MQLHVFQQLRQEISDAHVTVVTIQGHGNTMAMRPQDMTAADKEQYPSSPSIHDLKALMDQLSSMVGTLELLRFESVLASLNYETREVRHDTIKDAHVKTFGWALDSNFPLSKWLQSGDGIFWVSGKPGSGKSTLMKFLADHTQTKTFLKQWAGGNELVVASHYFWCSGTLMQKSWHGLLRSLIFDIFRSYPLSIQQACPERWARAGAPGAASTPWTIAELANALRAMATLQPSSSLRFCFFIDGLDEYEGDHLELCEIFKGLVRAGTIKMCLSSRPWPVFEDGLGKDLSRKLYVQDLTYNDIKTYVAAQLECHPKWKTNSLTETERMDMVEAVTKKADGVFLWAYLVTRSLREGLSNHDTVTDLTRRLEHLPGDLEKLFRQMLESVNPVYQSKMACFLQAATVYNPNSVNYNYPEIPLDAGIYCNMEKELDEPGYALQCSLVQISKASKTHDTFHEWLHNDNEHVSPELRTCISKRYAQMQDIINSRTKGILEAPIMQNRPQPPIVQYFHRTMHDFIQTTEIQEFLSSKLSNNFNIHIWIMKGHLIRRKGYPVESYRSDSSFIELHSDLGDEVTHMLACAANALSVIEREDFKAVFTLLDEYERALHHLSLQAIASEPSRKNKMLLMARYAGKRPYLNLATYFREMVVLYACRSLLSEYFEAKAMETPDYRDGLPGPLLLQFTVLIFSGNLRGLRLNRYSLRPCHNMVERLLRTGANPNEPFIDQTAGFHYAEEKMITSMHRQDPKQELERILIQFKISPWVFLMRICFWLYGVPVCQCTGDMETWQFLTAFEPDFRVVGLYLNYGADPNAEFWDREPKPLLECSEKCYGTKNMSIFSVFNPSMTGVQIHTPTHYVAEFLEHPMFGKPPLWSISCFFAYIWSPFQRPLRHQYQRDYLATLDTFLSKHPSLDASSHISDVITSLELDSLGWIILNDEPSKSPFVQFCAHICYKDTWTEDSALNQFRSAIIEKLIGYCGTINADEKFFTLLEFGISKAEKCPEDIKRRLLMLDLVEENRSRNDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHE0</accession>
    <name>A0AAE0JHE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_153810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682798.1">
        <property type="nucleotide sequence ID" value="XM_062821118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHE0"/>
    <dbReference type="GeneID" id="87858272"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53093" checksum="94343FEA07A7F4C7" modified="2024-05-29" version="1">MQFPEWLVWYKKPEYRNFKEYANNASSGKRSPSPYAGREGMIPSRLRLERILQNKTCSPMSLYDFYMYLKYIEFSSENLEFYIWFKNYEESYSTGLAYRYEKDSDGLAKTASESGSVSSSVFKKSHYQPSDGEGDEDSEKATTAGETLRRISLLIAASAPCAASVAHPSCRPCGPCAPSSNLAFPTTTFFNNFNNSRTAVLASDPTPDPSDPANKSTTLGLLAPQPGPIPPSEIQTIITLFLLPSSPKELNLPMSLRRSALDALAATPHGTLPDPKILRPIADHVYHLLHSCSHRNFVRLGVSNGTFETICFATFLGFVSLALGFLVVLVRAFTEGRGARSRWESFDGFGFWVVGMSLVLCGLRGSCFFLLLFSRRQRLPWERLNDGEKTEGVEMSGGQEENEEGKETKRRSVRQRVGRMMIFDKRLKVQERSLRRLQRKIVAQSMVGGTIFAALSTVVFFLLPIWKEMVCDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHL4</accession>
    <name>A0AAE0JHL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_162247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683094.1">
        <property type="nucleotide sequence ID" value="XM_062821262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHL4"/>
    <dbReference type="GeneID" id="87858416"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="77"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="206"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3348012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="330" mass="36428" checksum="939F50CBB7090AD0" modified="2024-05-29" version="1">MALVGVLSPLRASMRSTAARTGAVRSFSSYLVTPKELHEALKKAPPSPISSEPRVIPLCASWFLPNDPQKRTGLDVFIEKRIPKARFFDLDKVIDKRSPYSHMLPSSKDFAAAMSELGIRREDTVVIYDSQELGIFSAPRVGWTMKVFGHPKVHILNNFKLWIEEGLPTESGNVWTIECGTYPIPEMDEDKVASFEEVREVAIDSNNEGVQILDARSPGRWSGKEPEPREGLSSGHMPGSINIPFSAVLDPNTKAFLPADKLKEVFTKAGVDPSKPIISSCGTGVTACVLETALNEAQFGSPEKRKVYDGSWTEWAQRVKPSESLIQTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHL8</accession>
    <name>A0AAE0JHL8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_461046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682741.1">
        <property type="nucleotide sequence ID" value="XM_062826581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHL8"/>
    <dbReference type="GeneID" id="87863735"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="240"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="684" mass="76045" checksum="C0C24EB551BFAD3B" modified="2024-05-29" version="1">MSTWKEQQNRIRIKKEASSHPYFHGKNSSVCDNNLNFWTRSRFPPARVTMSPSDPKPVDAAAAEKQQMHEPPQPPLARAPSQKQDERLDSNRPEHLDHLDDPEAQHSPMSRRHTNTHMNTSSSSDDEYDTEKDSDEDADDHDGHRITSRDIRLTRTRTNRSMRPSTKEGPEYANTTGRLDLAKTVSRRDTVLSRLRSRPTARYEFTHPLAHTPTGKDVIVDFDGPDDPYRPMNWPMKKKVFTTLLYGLITMSASWASSSYSAGTALVSKEFHVGHQVAVLGTSIFLVGFGIGPLLWAPLSEVFGRRVAVFVPMFFAICFTFGSATAKDYQTLMITRFFGAFFASAPVTNTGGVLGDLFSPAERGIAMAGYAMAVVGGPAIGPVVSAAVAIQPSLGWRWTLYLTGILQAFVLVLGMIFIDESYPPRLLVNKARRLRIETGNWALHAKFEEWDVSFSELAHKFLFRPVQLLCTPICFLVALYASFCYGILYMQLGAIPIIFGQVRGWKQLVATLPFLCIFLGAMIGCGANVYNQFLYNKAYRAAGNRAVPERRLPPMMVGSVIFSGGQFMLGWTAPKNIHWIVPCIGLVCLGSGFFMIFQAALNYLVDTFTRFSASAVAANTFLRSCFACAFPLVVGPMFHNIGVGPGSSITGGFAALLIPVPFVFFVYGKRIRKRSKWSRPSVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI64</accession>
    <name>A0AAE0JI64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SDS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein sds23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_557372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SDS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683198.1">
        <property type="nucleotide sequence ID" value="XM_062830080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI64"/>
    <dbReference type="GeneID" id="87867234"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="281"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3348116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="535" mass="57545" checksum="ABD603E22A4E9E98" modified="2024-05-29" version="1">MESSSEIPKSPSPGTFPVSDAALSGASLPSPPERPSSQGGISLSKTASNVSSHSHRQSFAENQRHPPPSPRTQRHPSFTQQAIQDLMNHPPPNRHQNPRYVGRDWRDIAIGELLQPDEVKWAELDTSIQEATKTLFQSSPNNVVVVRQDSSSKEAISTFDHSDLNDYLLVVVGLAKPQEEQVALYRDISVKAQSQAEIPLRDLQPIFRHEELVKLPADSTLDKAIEVFGGGIHRLLVTNKDSEVVGILSQLRLLEFFWNEAVNFPEIDRLYTIALRDLQIGTQQIIAINADAPLADALFLMSSEGLTSVAVVDNGHNVVGNISTVDVRHLTNANSLPLLKASCMHFISVILSERGVEHGRDSFPVFYVNPYSTLAHTVAKLVATQSHRMWVVESASPSPSAPATPLLQASSLPPLSTLSPPVASPGRTGSPASGSATVVVPPPGAITTSTPQSPSTQGPFTSVPASALPGAGLSGRLTGVVSLTDILNLFAKSSGLRPLDPSEQRARRRRSSSSSIRPTLDIGRDNGRGSVDSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIT9</accession>
    <name>A0AAE0JIT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_178754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683639.1">
        <property type="nucleotide sequence ID" value="XM_062821478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIT9"/>
    <dbReference type="GeneID" id="87858632"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="260"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="715" mass="74450" checksum="5F17BFB897E20249" modified="2024-05-29" version="1">MSANDEKRKLEAQYFPPPPPGPPPGQAPSSSIATQQAPPQSQQPRHPDEIPIPDYNSSHPQYAPPPNSNKEDIYGVTPTDEHPPPFPPRPTSSGKAGDEKVKLSWGQKLAGWGTKAAAPINALANKMGSEAFLPGPMDKEVEKAARILRSFCKDGIYSDAAPTTAPPQTTFPVANKVEPTAAETASKPPVETKPVDAATAKKKSRVLLTIPSKVIAKAQGLAIFTTVRAGFQVTGASGSGVLIARLPDGSWSPPSGIHVHSIGAGFVVGLDIYDCVVVINSKEALEAFTRTRLSLGSDLAVTAGPWGAGGALDWGVPQGQKTDKGKGKDGKPSSRPTTADGKPILSSDNTQFTNPPVDPDFDPDHPEEAGKQANKNRKPSPFVEAVKKPVYSYVKSRGFYAGVQVDGTVITERKDANAVFYGRQVTVQQILKGEVAAPPVVNGLLEVLKGAEGWRGQQGQQGQQGQQGQQGQQQQTVHMPQGHIPQHHVQPTPAQQPQQPYPGQGQQPYQPQLLSEPSPEGYCAPGKPPGGPAGGPAPAPAGTGGYLYNPQLLSEQPPQGQGYGGGARGHFSPLNQHPTDAYHAPPPPASAYTESGPAEVSGVTSGVRGLDINSAGPSTGTAGVVPPAPGPQASDAARAKAAEAAAEAAHAHGSEPPPPSYEEFGSSSSTAPAVPGYPGHPAHPPQTDGVTDELPPAYAEDGVYRPDVGDHKRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIX6</accession>
    <name>A0AAE0JIX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_462353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683167.1">
        <property type="nucleotide sequence ID" value="XM_062826636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIX6"/>
    <dbReference type="GeneID" id="87863790"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3348085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48660" checksum="A5B984EEBCBA3EA0" modified="2024-05-29" version="1">MGDSGENWPEPVSSLQSMQLDLPPSCIEFCPFAPSYFLIGTYNLEGYEGPAAASTAEAKDVEEQDEQHDDLEARVTREKEGPQNRNGSILTFQLVDDQLVHVQTLMQPSAILDLHFNQAPGKQDICAAVSSTATLALFRLSPGEPQPLRHLKTMDMASMCKTAEDWLGDKDEVIFTHLSWHPTKSDMVAVTTTAGYVHLIYLGDDLVGGDWVMHPEPILTHTLEAWYVSISPSLSPPFSQDKEEDDSFLLLSGGDDSALRYQVCKRTRADAVDDDESESPYTIEALRPPVNVRGHGAGVTAIVPLGLKDGESELVVTGSYDDHIRLFSIPAYGFGRAVELAESNLGGGVWRVKIVKEEMGLLDGQGWRLTMLVSCMHAGARVVELLKSGARKYEFRVIGRFEEHKSMNYGSDCQLSAEGTLSVVSTSFYDKLLCLWKLELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ00</accession>
    <name>A0AAE0JJ00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerato-platanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_454835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683744.1">
        <property type="nucleotide sequence ID" value="XM_062826210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ00"/>
    <dbReference type="GeneID" id="87863364"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042257413" evidence="4">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3350449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="138" mass="14400" checksum="F9A3F7DA921CD74D" modified="2024-05-29" version="1">MQLSKILSLFTLATAASATTVSYDTGYDDGNRSLTVVSCSDGSNGLMTKYHWNFQSQITNFPYVGGVEAVAGWNSPSCGTCWSVTYNGKTINILAIDHAGSGINMSKEAMDALTGGNAEQFGRVDAVVASVPLSACGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJC6</accession>
    <name>A0AAE0JJC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_439738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684040.1">
        <property type="nucleotide sequence ID" value="XM_062825437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJC6"/>
    <dbReference type="GeneID" id="87862591"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042217914" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="110" mass="11700" checksum="FF8AE0569DDDAB2E" modified="2024-05-29" version="1">MGRLTTLMLSALASLAAMAQADCDEGAMQCGRQLIDDEGYTQADLIAILNNTQQPYDNDHIFESIFYCDSSNNGNGWVYYEWCGGQDSCVAGGDGDDAGCAAAVARVDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JJD5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_439750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684055.1">
        <property type="nucleotide sequence ID" value="XM_062825438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJD5"/>
    <dbReference type="GeneID" id="87862592"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="285" mass="32942" checksum="85E75E97CFC0AA05" modified="2024-05-29" version="1">MAAASTERTNTLTSSVSSDQKVQEPANDIRHPRWPLWTDSSPDAGLELPELKGEDNFELWDRSVLDTFKIYGLEGFVKGTETPPPSDTAEDYLDLQTFNDRRLCAFRIIYTSSTPIHLQLLPYGYDGYQLPDVLDPQVLWDAIHRWDVAVHLNTLAKVKLVRELSHIHHSGFDNLREFMRRANWLRRRLERAGVPIADELMKTYVLSGLTRYPDENWVTSLFIKASDWTYFTLGTNIEKQASWESVGECQVKPSKPQHLKKRRNARGRRPGHPHREGARQRGSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJF5</accession>
    <name>A0AAE0JJF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_420765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684057.1">
        <property type="nucleotide sequence ID" value="XM_062824302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJF5"/>
    <dbReference type="GeneID" id="87861456"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0034456">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
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    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="202"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3350762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="323" mass="36406" checksum="EB0F853C553CC314" modified="2024-05-29" version="1">MAPSPQTIGEFSVLPISIPPVPSFPRNVVHYLYVRRNAPKIPTANDSRSLFLANVPVDSTELHLRALFASLVGAGRFESASFEDERKEAEAVAAALDAAPAQAVRLLAAHGKKRKREDQEAVERAEEEAAARLPSTWTRPLRKSGSTAVVLLADEKSVQQVLKAIAKVHKSKKYPTWGGEGNVVSERVPQLGSIWLKAHNQLSYPDRDQLQAAVDAFSTMFTRREREAAEIAKRLRNEPDEDGFVTVTRGGRSAPATRNEAEEAKKMMIEKAEKKKQEMTDFYRFQMRERKKAEQEELVKRFEEDRQKLDAMRQKRGRFVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJH2</accession>
    <name>A0AAE0JJH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein EsdC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_98951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684084.1">
        <property type="nucleotide sequence ID" value="XM_062831662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJH2"/>
    <dbReference type="GeneID" id="87868816"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30232" checksum="E6A6E86662445B0B" modified="2024-05-29" version="1">MSAIQLSFSLRVSSGVKTVHLLGSWDNYAGQLPLSKDKTSSKSGSWKGTFRFQPALVQPGQRYWYYYIIDGYHVSHNPSEEFTVEPTTGRSLNILDVPKSSSSSKSSSRHSRDSVKSSKRESLSLDIPKGRPLSVSQIKAPKPMSPHATRHILDADYNIDELSSRFATTGIYDEYDEDVITDFDMRSSPVSSTGSSVSYRSDSSSPSSSLSGYSTPASDCSSCICERYGITRKGERVRLDCGGSRCGYEDSCSSEDEENYVERSSRRNGIVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK05</accession>
    <name>A0AAE0JK05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_106836</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684329.1">
        <property type="nucleotide sequence ID" value="XM_062820498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK05"/>
    <dbReference type="GeneID" id="87857652"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3351034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="385" mass="41988" checksum="2F71493791549ED8" modified="2024-05-29" version="1">MSFSSLVQDLSLRDPNAPRRRGDASVSTMDDRASRTSHISRAMSYASTAATSVSIAGDISSQLHGGYAHPLARSWQAERQLTKSMLIYPLFVSDNDDEEVLIPSLPNQYRRGINRLVPFLEPLVQKGLRSVMLFGVPLKPGTKDALGTAADDPEGPVIRSIRLLRQRFPQLYITVDVCLCEYTSHGHCGILRDDGSLNNQLSVDRISDVALSYAKAGAHCVAPSDMNDGRIRAIKLKLIEEGIVHRVTLMSYAAKFSGCLYGPFRDAAGSCPSFGDRKCYQLPPGGRGLARRAIVRDMNEGADIIMVKPASQYLDIISDAKELGKDLPIAAYQVSGEFAMIHAAAKAGVFDLKAMAFESTEGILRAGATIIISYFVPEFLDWLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKZ1</accession>
    <name>A0AAE0JKZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_124283</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684824.1">
        <property type="nucleotide sequence ID" value="XM_062820721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKZ1"/>
    <dbReference type="GeneID" id="87857875"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="774"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1122"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1160"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1172"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1228"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="803"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3351529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1240" mass="137769" checksum="23E0A31E1589DEEA" modified="2024-05-29" version="1">MGSSPPAAAGPLLDSRTRHDAAMPNGSRISKDQPRSLTDEHALGMNTSRPTTSPAAAVVNRSSDPDPVPDPAARHKPNPDRPSGSNGPSSKSGKPRGRSIEPPSSSSQPAPRHRHPSRHRSPDRSGRSSRLPHPHRSRGSPRSRRDRSREPRGRDGHFSPDRRHRSPGPPRGRGDAAHERGQNVDHGKQHSQPPPHPARASQRASSRSPGSSKRRRSRTPSPGGPESKRSRRARSPRRGERDDVNSVQPPRDRRRSPFDRRPSRSPNHHERRRSRDRKRSGRSRSPDRSRRRKSRSPDRGVFDQASERVRRRSPSPRHRGRSDRPDRPERRHQSRSRSRTPPHHENRHPASDAGSRRRPSPDPDSREPYDHPQGSPRDRRRSKSSKKGKSRDDQKFDPASGVNSIEVNMAARNGYRGGYGAPMPPGYTETHDGRNYSHSSGHATPNSSFHGSPPAQSPYGAGRGWNNPQFSPQSQYGYPHGNYGPPTGPQAHYHSNQGHSPPYPPTGPAAQYPTGPYRSGHRAASGGFRGGSFGVPRGGHRGGSKGAQWSPNAHNASGRGQYTTTTTENNSAHPQNSAAPSKHADSGQNTQEGAREDVNNSSRPAKDSQGDDTNKSGKEKEEQMQPPTRPAAGSQSQPSNKFSFSMKNATKPAVAAPRPEISLKFNAVVPPREPSQKQPPKAPAAAPPTAPSAHRSNRDRHDLPKNVPTEPASARARHNDRRGPDQHRPVDSHRPAEQQKPRTRIVKKIVKKLKEKPALPPDLAKSKSVYHRKPGNESVIGSGTYGKVFKALNVYTKKQVALKRIRMEGERDGFPVTAVREIKLLRSLSHKNIVKLMEVMVEMNECFMVFEYLSHDLTGLINHPNYTLDPAQKKHLALQLFEGLDYLHTRGVLHRDIKAANILVSNEGVLKLADFGLARFYAKHHQLDYTNRVITIWYRSPELLLGETQYGPAVDIWSAACVMMEIFTKRAIFPGDGSEINQLDKIHSVLGTPTRNDWPNIIEMPWFELLRPTQRRANVFAEKYKELVTPAAFELLLWMFKYDPDKRPSAAEVLAHPYFTTEEPAPRQAVELKDIDGEWHEFESKALRKENERKEREARRAVKEGAPTTTAAPSGGGGSSSARDKDRDPRKRPAETREPPPSERDSKRPHLDPNAATKPSTTTSSSASHQQQQERQRQREPERSSVPTRPRDQQQQQEQQQPRPSASSSSQLPPPTAPAQAQSRAPTNAPSGPAASQSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMY8</accession>
    <name>A0AAE0JMY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_18500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685965.1">
        <property type="nucleotide sequence ID" value="XM_062821562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMY8"/>
    <dbReference type="GeneID" id="87858716"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="12"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3354587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="432" mass="46992" checksum="7F97C9439A6F6144" modified="2024-05-29" version="1">MLPPPTPSFQTRKSRILSQLSVPDAEYTDASPKGSVDVAIRELIDEINHGYEGLVTTSSCAGRVSVYLEGVKRKKQEDKSSSGGDGGQGEGGKDGEEEEGGELEDAARAATVTASSSGGKGGGEWLFVSHDPLETVDPSTGREHDGKHWMEVFGLTGGNGSGTESGDGDGEEQQEQQQRLIHFKFEPMILHILTTSPSHAHLAIQSGMTSGFRETGAVSILPRLTAPFFSSCHQCHTHQHHQQPQQPSLSSSSTPPPAAPNSSSAAAETTATNTPNPIVAIRSMGLSFESLIGAQRGSSQRQALVSPEYLSLLVKIANERFEENKKRIARLREALRLAFGDEAGAGVEEKKKKGGDAGDWEDAEARKQRKREEGLARREEVRRRKEEERERKRREEEGKQQKQEDEGKQEIKEGKEGKVDLAEVVLQVPDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN26</accession>
    <name>A0AAE0JN26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_504318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685561.1">
        <property type="nucleotide sequence ID" value="XM_062827901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN26"/>
    <dbReference type="GeneID" id="87865055"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="954" mass="105913" checksum="8DC971EB252F6A97" modified="2024-05-29" version="1">MGSLAVGRESQGAISAAAFVMPDGQQHVPHVPANGIGAFHALLDLDDMSVDRSFFMPLSLLEPKASPAGCPAGCSGCPPGDSTPFTGAATPSPTPPDHHVRQRLEQLDDEPLVEPWTYVPQTPLSIDNRSPRDFAFHLPFRFLPNAKHDQNTNIGTFLDDSSYPYTGSSERHHLPDLGLDEFGPFHVDVDLPRSPVYRSFYLSPSTSTTSLASEPCTYHHYFDNSSTSFSSIKHGAIMPDPTAVASADGAGPSGRPNFAAKTIAQRRQRPHSAHSEQLARLPSPFFSLWTKRHHHQHMDHNGKPQQPFEYPGHGFTDTKPTTHKRFTHSRSSSIGTRQSQANAVPQMTREEFEALPLAIQRKVHVQLEASSPLLLSGDDTHPRAPPSEHHSRPVSDWGSGELAPRGLFAERFSRLSKQLRFCFFEASHATLVDEQVPVSKGKSRDPISIHFRTLAASFDSPACRSNACQLRFARESYLIDGITRHYDEISNFKRQKGHKQQSRSEQIVSRNGRGPLGGEPSLPSPVLEVPQSPLDNMRQQELTREEQVALARRLRASVILDAADEAIYKMNRRTSGHPSVNREGLMSSHSSLQTTTEPRDGVQSRAEQPISQELPQSFYDSFRWIDEEDDLDLRLFLDDYHKNLRDSLPSPKQTRPSFRRQMSVSKRPFGLSSMPTPTSRPGSHNDLATGSPAPTSAGSVANSDGHTNRKARTLSLITPKHSSHESVFDPSAAHYQDPEARLKLRVYLASPQKFDEAIEFGFPSTDALGAGPIIRTEFMETPLGPGRRKVQSTQKGEDTWAMGTFLADDDDEHVSLNSDQPSLADPESPKTPQAFESRPHPQRATSSDPTFLRDGCGMFAEGAGGYAQAPANSREMTLRMTLTRPDLRAHENEIYGWQQKPVYRNTRKSMSLGGFENKGMFYGEPILNESLENQASTTSEKGVMKRIWKRVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNC6</accession>
    <name>A0AAE0JNC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_554146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685871.1">
        <property type="nucleotide sequence ID" value="XM_062830000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNC6"/>
    <dbReference type="GeneID" id="87867154"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="550" mass="61425" checksum="F3B73C8F10EDAD95" modified="2024-05-29" version="1">MASLNEDLAEGTPQDDGANVPRMEILAEEIAETLPINRPAKRKRDKMDTQDNLQDPLQTATEENNGNNAKFSRNWKPPQGIITDKDLEDIYASLGLSSTRINELRKYKAVREIALRKNKDTIDLTEKHQLGAAYLQLTGERAQNPCKECLAGKGPFELCVYGSGRRCGNCWHRHTGNGRCSFQKTGKENGVSEAVSKPSHHADKDASRSDTESVSDLLSEAGIGVGLEHHPEPEPEHQKGGRELRPRPPQPPQPPRRNKKPPQREQNIRVTEPVTQPQARHESSTVFTNPTTNTTPPANAPNSPSIRPGIDTPLSPPPAAATPTRQALPSGVYKPQFPPAVASVVNAQITRERCGCGSRDIRPERQQQIDNNTDPDRDREREREKEKEKEKEREKQREKQRTHIVSDRSFSLGGGASPGPPNSILACLPPNTPVEIMRCLMQYHQNHADELRLECMSIVKDGRGGSRPAMAWGDAGGVGPSSILACLDPNQSPLETMRRLGLHYQYQADELRLECVRIEREERMRRAREREREWERERGGRGGREDGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNK9</accession>
    <name>A0AAE0JNK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_14638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685861.1">
        <property type="nucleotide sequence ID" value="XM_062821014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNK9"/>
    <dbReference type="GeneID" id="87858168"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1076" mass="113638" checksum="D37724C3AC92F0C4" modified="2024-05-29" version="1">MMPEQVASQPAVAKRPSDTTHRNPGAPNSNNKYQINVNRSKTKKWANFKPQNYDGDDWGSDEYDDVDEEPPSALRQPVKQYKPYTPALHLQTQQPPAAPSGRIAQMVAASSTPATPNALQRAGTFGQPQFDAPPTSSPVVGGKQALPSMMRVATMPQNVGPASTQFPPRKSSMGPREIPDMTDPTRQSRSTTWAVPTQRPWSDARSASPNARSPVSPNKPLPLPRPTDRYRRMGEDNNAGLQSSGSVNQGQLGNGAHTAGLNSGPGHQERRGSAAGNEGGDNSWGRRPSLAPVMERNSEYGAEGMLAGPASKESGVEPVAFGEEEDKVRRFSTSPKLPDLTRLSGFGEDLFSTRFSVLAPQLASIPDISNPSSPAKAPEPEGISTDERAEKGGNSENGIVTPANPSVAPTSLPVAEPMSTAQAPPPSTSIGGAAVSDATPQLAQKAIRSQSPPDESVGLRYNQDDANESHAVANAPQQLPSTMETPQETISSDMDKQPVRPRLPGGWVTETLSTPGETPPPARNETFSNMTSNFPQPPSASLVAKSHADAERASNGGQSQQHDPSETSEAAIESSHSTSDREAAQATPTSDKDIHASLAPTMEPSKHRDITPTAPLNFNRGLLGSKSAEPLHVLPSPNMGGGSTLNTPGDSPLKESDLLRDEITKFLGDPEISGSFLDISRSSTTPNHPVADATRESSYFGDVYGDYFAASEDNQSQTKLGATTQPAATDTLTPVAAGTSKAVVVAPLSVATSTSSGSGAATSVSKQDPTGETAGAFELRRRFSWEGPSEQDASNAPEVDPAYHVEQKSRTSGPDGVSLASSTPAAEKIGETMALTLSNADESLPIPTETENKPAPEASGGISHDVSEVSTLPSRSMLEPASPISAGSDEAESRRRALSLAQDQALPQPLDQHPAFGEKASIRRGSSGPKDPVNIISFRQIMDMPSSSDRLKHYNETRLQFAAIDTGLEEWLLAMKSKYPEHSNATSSFKDSLTIPVMSMDNQQSGEVLSLQQGGRPGTNMPMPPSLPYGHSGFAHSSQQVGTKGKELLFAAGKAGKGLLSKGKSKLRGTGDKVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNR7</accession>
    <name>A0AAE0JNR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_515372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686400.1">
        <property type="nucleotide sequence ID" value="XM_062828656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNR7"/>
    <dbReference type="GeneID" id="87865810"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="265"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="907" mass="98017" checksum="F86E3329672596C1" modified="2024-05-29" version="1">MSAPSNGVDTTASSSKMPSTAPTSTAATAARGTPTGAVSNNITTIPSSSNPSLSTSANTTNKSHDKTAPLSLSLPIRSITNPQNGGNGSNDPNTAAAADPALAALRTASSSSDIRAALAALHARESSLTSRLSSVLASHQDLARSLSRLDNLRAGLGSQVIAARSVSNNMLAGAADTASHLSSRVRQLDLEKQRVEDTLRVVELVAELKACVAGVVGSMGAPQDWEAAAGYIARAARVPEEIVRSGFAAAVVPTVEVPDAPWVTLENARESLCVLFLREFWKAAKEDDPAKITRFFKLFPLIGRGDVGLDAYGQYVCQGVADRARAILKDGVGAVGGAANANAPATLRPKKDGIFYANALNLLFGHITQIVDGHGGLVERHYGGGKMIKVIERLQGEADVQGGIIVDSWSDEHGVDRALTDVKSYPFSFLVQSFLPQNRGFGAPPRLNSPAPGGDGRNSEDEGVSMREVDALLSEIAIMLSRWSAYSHLLAQKCMEPGVPEDAPLTMPEVLTKSNLSRKVSGKLVMPYNVLTTFFFRRSVEKAFQLDEWPTGLSLRMSKPIDSSPPFIVSAVEDVMYIANTVIIRSISTSQRGVIDSVLPTISSLLGSDFVGMIQRKMRDECYPKPVIQGGFPPEDKIIQFIVLINSLDMAEEYLTRIITGILTPGEQSVNGGTGAPSQASSLKNSFPFKNDLKEVATRLNNLHHSFTAKATELLSEGIKVLFSQVVRPRLRPILSDTFRDADYTMTEEELLDLCAQNDENEDDVLEQVTRRFEEGWDALMKPIARLMTPKTFSTVLDHTAQHLARWLEKRVWSYAGSQTRGASPYGAIRMERDFSGIIGTISKGNYAVREVFGRTLQILMVANMEDEEWEELIVTDGAAGEDGEDGMLWVLSEDERRKARTIVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNS9</accession>
    <name>A0AAE0JNS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fms-interacting protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_30966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686349.1">
        <property type="nucleotide sequence ID" value="XM_062823277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNS9"/>
    <dbReference type="GeneID" id="87860431"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3354971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="24440" checksum="4F38FF1E6DD5FFC4" modified="2024-05-29" version="1">MAADGPITDPLLVTVLDTSRAAREQAVVLIDRIQEALDAAGNGPLPLEAQAEISKQQKLLNTNIAQLRGLHRSAHFKARETKGQTAEARHEVDVLHLQLQNLYYEQRHLEGEIAACESFEHTYQKLPLIPVEEFLALHPEHADDDENDLMVARINHERTEREALEQQRVELQKRKQKLIADNKKRRDDLANLDKDLEKFIDAAKPIQKLFEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNX1</accession>
    <name>A0AAE0JNX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_437744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685762.1">
        <property type="nucleotide sequence ID" value="XM_062825329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNX1"/>
    <dbReference type="GeneID" id="87862483"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="470" mass="51911" checksum="4484444B8CC2F9EF" modified="2024-05-29" version="1">MAMNLRTGSRALGGALRNHARVSRRGYTTAEPDLKTVLKEAIPEKRELFKKVKAHGNKVLGEVKVENTIGGMRGLKAMIWEGSVLDANEGIRFHGRTIKDCQKELPKGKNGTEMLPEAMFWLLLTGKVPSTNQVRQFSRELAEQAALPDFVNKLLDSFPKDLHPMTQFAIAVSALNHTSKFAKAYEQGLNKADYWEPTFDDCISLLAKLPTIAAKIYQNSYKGGGALPAEVDLEQDWAYNFAAMLGKPGKENENFQDLLRLYLALHGDHEGGNVSAHTTHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWILQMKEAIPSSYTDADVRDYLWNTLNSGRVVPGYGHAVLRKPDPRFEALMDYAASRPKIAADPVFQLVLKNSQIAPEVLKQHGKTKNPYPNVDSSSGVLFHHYGFHETLYYTATFGVSRGLGPLAQLIWDRALGLPIERPKSINLEGILKEVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPG7</accession>
    <name>A0AAE0JPG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_415432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686017.1">
        <property type="nucleotide sequence ID" value="XM_062823985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPG7"/>
    <dbReference type="GeneID" id="87861139"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="49" mass="5537" checksum="AD3CE32AD1624A64" modified="2024-05-29" version="1" fragment="single">TILKTISTSNRTILPFVLLPGVNITYKYINNSLNNRTILAASVRKYINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ02</accession>
    <name>A0AAE0JQ02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_505283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686741.1">
        <property type="nucleotide sequence ID" value="XM_062827980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ02"/>
    <dbReference type="GeneID" id="87865134"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
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    </dbReference>
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    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
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    </dbReference>
    <dbReference type="Pfam" id="PF00780">
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00036">
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    </dbReference>
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        <property type="entry name" value="DEP"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="385"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="554"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="930"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3355363.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQD6</accession>
    <name>A0AAE0JQD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_564716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830263.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87867417"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="146" mass="16910" checksum="FD2CDC60EDD38830" modified="2024-05-29" version="1">MTDEEVKQWFLDADREYEEKKKAGYHKNYVPAGGHTPDFSSFIRAHSRPQRTTGMENSMYAPKPPKPGQSSKEVAPFHRDIYRSMAAYNAMLKTKKEQPEVPLQPHTLKESNFPTLEPFNCNAYRSMDSYNAMLKTKKERSCPCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQU3</accession>
    <name>A0AAE0JQU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_54881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687046.1">
        <property type="nucleotide sequence ID" value="XM_062829604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQU3"/>
    <dbReference type="GeneID" id="87866758"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113239" checksum="5F33DD502F969CC7" modified="2024-05-29" version="1">MLSKPGSTIRKLVSPRKTLFVEEYEGSYFHHDDEGYRSVYRELKMRSWGLRRGSKPDLDVPKKEDLHKILTIIPPFPDTPLSSRSSLSSCGYSTDHTSPQCSSRRVGGQSPQRSPLLCPEHLEHQPQQARGRSQPSSTTPGTPPRTPSTQELHQIILLPPSPPLQQDEPNRDYTIRRPSITLTGLGINHQSISAEEIAEGYTGSREQHRSPSNGYSNDIQQLIPEMDRAFQPQRSPIEIKLPLPALVIPPTTYYSANHTKPLTPADTPSQWNKARRRSQASLQSFTQPSKRSFLLTSPARFASASRTKRKKSKKSQRRPRIVSTQVSRWALPDTARNLFERFNPIEANEVLPESVLQEIMDRACLAQSAMNDGVTATGQEGDQTSQQPITPVEPFHLDDLPTRIDNAGVSLTVTSATPPLETARPSLSDHGEITRDDCATPKQQLQEDGQKQNRPRSPPVALAEDGKEHSLPIMFRLEEEEAQQPPKPPSVAHLTPSTTGPIRPVPRRTPSRQLPPLPTIPEGITSSMLTPTSTSSPGFGSDANNDDFIFLKGTPYTWTMPSFRHGPIRLPKPEPPINLLAANAEYGLDWVAFQISIGSGIGDFDSDPLDYSRPSDAELNERDDIIAWFSGFGFDGYGALRTFPTADEEIELMKHRQENAPLHTHSASSGSPLNMGRREPPDSGSRGRVPTGNALRRIQHLQAYDWDRKHSHERSASVNGHLPLHAPATHIAAHQMQQQQQQQHYLPWISRETPSSTWPIERQSRDHLEKPTTNTPYGHAHSQSWSYSLSPFQAPTSNPTVRRDHSRGRSQSDAANNNNTNTNNTLVPTSINRNQSPTLRTSTPTKTLTSRLQPSHTQRPGTPQHQIQQQYSLALTSSSLFSSPTIQRSESPFLPGGFAFQYEQQTVIPSSIVPTTQQHQQAPPPHSQPTKQTAKKISQAIDAARARTWQQGSQGPRHRRADSQESIKSLPQSPALNMVVSRDVNGQEYVIPMGFNLDHDLGDFLKWEAEHVALGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRK4</accession>
    <name>A0AAE0JRK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_482713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687550.1">
        <property type="nucleotide sequence ID" value="XM_062827659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRK4"/>
    <dbReference type="GeneID" id="87864813"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="131"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3356173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="656" mass="72574" checksum="4966A61BCFB44AA3" modified="2024-05-29" version="1">MKPKKRDTMPTDIEMAAYGSRGGDSSFAQGSSWSIREPFGVGHVPAWARGRHRQEPRLRRFIDSFKRDPVRRISTHGIYGHGHPDHYRDQAQDSSEPSFEPTRERSHYFDLHAANVRTANTGLARELKGRHLQMIAIGGSVGTGLFVASGKCLFLGGPAALIIAYGFVGIMLWCTIQALGELAVAFPVAGSFSSYSTRFLDPAWGFAMGWNYALQWLTVLPLELVAASITIGYWNEHLNKAIFITVFLTIVVMINLFGVKGYGEAEFVFSLVKVTAVTGFIILAAVINIGGFPDDPQGNTGYIGGRYWENPGAFHNGFKGLCSVFVSAAFAFTGTELVGLAAAETANPRKSLPTAIKQVFWRITLFYVVSLTLIGLIVPYNHPRLLGNVTPGKEKDSYSVSDTSHSPFVIAIESASIQVLPGIMNAVVLIAVLSVGNSAVFGSSRTLAALADQRQAPQILAYVDRKGRPLFAILFAALVGLIGYLADLKFQADVLNWLLAVSGLSSIFTWGSICLCHIRFRRAWARRGRSLNQLSFTAQAGIAGSYIGLFLNFFVLIAQFWTAAFPIVTFTDNQSPDHASTSKVVQTFFLQYLCVPIVVAFYLSHKFWFRTRIVRIDEMDLDTGRRRDVNLPVLLMREREEVEGWPGWKRVYRFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJE7</accession>
    <name>A0AAE0MJE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_553610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676848.1">
        <property type="nucleotide sequence ID" value="XM_062829976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJE7"/>
    <dbReference type="GeneID" id="87867130"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="268" mass="29048" checksum="AF472021F9468107" modified="2024-05-29" version="1">MGLPFYRSPSSEALRRQAADQAANQQQQPDPRRARSGAPPPPLRREDAQRLFPQTTSEAATGSQERPIDLTRRALEVEAQRRPAPPPRLDAPIPSTEDEESDAAASAALYRYSRTRFDSSELATPADEEELRLPDYGTPDVDWSTPEIEAASTHPRPAQSSPPPPQPQQRQQQPEAGPSQAGTGQQERQASGGRETFVQVTVDEGRGPLVQVRGGEGQSIPPSRRLPLPRPSDATIRGPRRQRLGQSSASSQGTSSQSSRSSGSRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJH3</accession>
    <name>A0AAE0MJH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_388779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676923.1">
        <property type="nucleotide sequence ID" value="XM_062823729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJH3"/>
    <dbReference type="GeneID" id="87860883"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15533" checksum="849CEBA1C8E7A148" modified="2024-05-29" version="1" fragment="single">ASRRAADLHKRATDLGLKVDHRKTEALYLPPRGKNAKKIWRNPTRITVDTPLGPVRPQKEMRWLGPGKNGNPVSTNIKSALHELETAASKALRKTMPIWRTVPRQIPFWLAGIAPPEILGRETARTAARLHTLPGNHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJN6</accession>
    <name>A0AAE0MJN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein arginine N-methyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_338650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677118.1">
        <property type="nucleotide sequence ID" value="XM_062823605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJN6"/>
    <dbReference type="GeneID" id="87860759"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="167"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3334952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="346" mass="39717" checksum="1C8E205D165E1440" modified="2024-05-29" version="1">MAANDQMDIEVAEQKLKSMDHAEQHYFNSYNHHGIHEEMLKDEVRTKSYMHSIVQNKHLFKDKIVLDVGCGTGILSMFAAKAGAKHVIGVDMSTIIFKAREIVKVNGLSDKITLIQGKMEEIELPFPKVDIIISEWMGYFLLYESMLDTVLYARDRYLAPGGLIFPDKATIFIAGIEDGDYKDEKIGFWDNVYGFDYSPLKETALSEPLVDTVDVKTVVTDPVNILTLDLYTCTTADLAFKSNFELVARRDDFIHALVAWFDIDFTACHKPIRFSTGPHTQYTHWKQTVFYLKDVLTVQQGEKVQCSLHNRPNQKNKRDLDITIDYKFENQDPTRQAEGRCLYKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJS2</accession>
    <name>A0AAE0MJS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_392846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676926.1">
        <property type="nucleotide sequence ID" value="XM_062823756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJS2"/>
    <dbReference type="GeneID" id="87860910"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="107" mass="12768" checksum="833A303A6AB2303C" modified="2024-05-29" version="1" fragment="single">ILKTIANKNKITSKLGKNNNSKRNNKKEYSFNSISAPKSINESRGRGAARQSSDRYEETTRLFNKGKYFFYKKKGYIKRNYSRKERFHYECYDYITTIVNCHLVYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJV8</accession>
    <name>A0AAE0MJV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_480104</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677016.1">
        <property type="nucleotide sequence ID" value="XM_062827559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJV8"/>
    <dbReference type="GeneID" id="87864713"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000247">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="18">
        <location>
            <begin position="118"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="19">
        <location>
            <begin position="547"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3334850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1017" mass="114806" checksum="CEC22F9C76F154B6" modified="2024-05-29" version="1">MRQWQPSPKIPSPNQQTSPACRTTRPPSTPTATMASLKRSFESDPLAQNISSKVYVRSTKSGKVQKIVREVYLRQDIPCSSRLCNACLKIAPKDAANRPIPFVLSEKPAGTSVFTQGHYIVPDTNAFLSAMDLFEQSSAFYDVIVLQVVLEEVRARSLPLYNRLVSLTKSEDKRFYVFFNEFRLETYVTREEGESVNDRNDRAVRKAVKWYNEHLSKTSKKAPAVVMLSNDRDNLRKAKEDDIPAYSLADYVRQLKDGEQLLDMIPELEERDALIEKKPGQFLYPEYYTLSKMNTGVKNGLLHQGIFNVSPYNYLEGSTRVPAFPKALLILGRENINRAVDGDLVVVEVLPKDQWKEPSTQVIEEEAVTKNENPTEEGSDLISEKERKALQEEAKRTLAKTTEGHALPTAKVVGIIKRNWRQYVGHIDQSSVSSSAAQGRKQDSVFVIPMDKKIPKIRLRTRQVAELLGKRILVTIDAWDRTSRHPTGHFVRSLGELETKAAETEALLLEYDVQYRPFPKTVLDCLPKEGHDWKVPASMDDPGWRDRQDLRDLLICSIDPIGCQDIDDALHARALPNGNFEVGVHIADVSHFVKPNNAMDTEASIRGTTVYLVDKRIDMLPMLLGTDLCSLKPYVERYAFSVIWEMNSNADIVGSRFTKSVIKSREAFSYEQAQLRIDDASQQDELTNSIRTLLELSKKLKQKRLDAGALSLSSPEIKIHMESETSDPIDVKTKEHLATMSLVEEFMLLANTSVAAKIYEAFPQTAILRRHAAPPKTNFDELANQLRVKKGLDLSVESSRALADSLDQCVDPKEPFFNTLIRIMATRCMMSAEYFCSGTQSYPEFRHYGLASEIYTHFTSPIRRYADLVAHRQLAAAIEYEAVHPAVRSRGRLEAVCKNINVRHRNAQLAGRASIAYYVGQALRGKATEEDGFVMKIFSNGFVVLVPKFGIESLIRLRDLAEPEPAATYDAETYTLTTSGSREVKVELFQKVKVRVTDQKDETTGKRGVKMELVSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNA4</accession>
    <name>A0AAE0MNA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_591973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677404.1">
        <property type="nucleotide sequence ID" value="XM_062831115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNA4"/>
    <dbReference type="GeneID" id="87868269"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="37"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="635"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3337953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="723" mass="81017" checksum="B89D669488A520E6" modified="2024-05-29" version="1">MGSMAFAELSEALLTVDDLGNPIYLQKQDVLRDMGIETPPLQIVLIGGLSSGKTSLLERLTGCTLPYDGGPTTRFATRLTFRRDPIKSIVTFITPKGWSQDEDTVKRLRSFHHVLDNLDAKTLADTVEEAAALMGLPTGFVEHEHDVSLCEDILEIEISGPDQPNLAFIDTPGLLGAESLGPDNSGKKKRSLVDGIARNHLTNEQTLILAVISSFSDRAKEDVLRLAKAADPKGVRTLCVLTHADMVKGEPKVQTILAPAREDTHALGCFWVRNRGADEGELSAGQCRTRELALFAESRRASFSKLGRTGVDALKSALRMPLKNLANECLQRQRTELLRRLSACKKERLALGPPRDTPTNQREYLMERVSTFERLASAALEGHYGADRLFTTNAVYKLVTSITDLNYKFCNAMRKRGHTYYFKNEKDDDGQFDCNVHGFMQGLRELCEWAASCEELGEFLHPYKGEEVDAMTKQEDSIIAYLRAVTSGLPRVGIQSTPGESIFTMIFQEQAENWTLHANYLMKAAIFNVHRFICQLMEDVFEDSWIRTELQDLLSEKILKAYKRAWDHKDFLVKMELGCRSQTYNPHLDAAILKIGRENFRTTLIESYNNEKRRLQPESAFNAAVKVAFGSSGVEDDLHDLLQAYYTIAIDRFLDNVCRQAVSYFLLEADDGPVKILTAEFIANLSDSQLDRIAGEDAITRATRLSLDAECEPLENALKVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNB2</accession>
    <name>A0AAE0MNB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_433048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678243.1">
        <property type="nucleotide sequence ID" value="XM_062825038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNB2"/>
    <dbReference type="GeneID" id="87862192"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF3">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="519" mass="53888" checksum="B26A8C0781408FF5" modified="2024-05-29" version="1" fragment="single">VISITLVYLFVYAALLIGQILSAIAAPNAHTKGILTITRSFTSTVTAGETFTTTAPSPVIVTQTVHDAPSSSPSSKAVETVHDVPSVPSSSPQPKPKTPVNFHEDYKTWYMWEEPDMWEHNGYKGKNIKGKRSVENKDWRRIPTGLPTPKPEIGKGKRELENVEDANLSTSYRTLTATITPAPAPVAPPAPATTQQQQQQPQLLPGQIRATRSDLDGIAVGSGDWQAKNIDEVHMFVWDADHPEYVAIGGQYAALVSTLVKAAAPAPSPSESPSPSESPSPSPQVQVTTQQQEEGDQPDGVTRITLPGQTTESILMTMNVTTTITFPSAEVSTSLVTIPAGQIGNSEATVLSVVVPATTSAAEAPVAPDPGPVVVNTAAAAAGASDSVVTSLLTVSAGQVGNKEATVMTVLVPVESETTPSEAVVPAPAASTPAALTPTTTSFITFTPPVPAPAVNTTPSATAAASTSVSVSEGPQAQKSPSPKAQSENNVEWETVVPGQEVVVNGQTVEVVTVMTGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNC6</accession>
    <name>A0AAE0MNC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GLEYA adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_579848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678288.1">
        <property type="nucleotide sequence ID" value="XM_062830781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNC6"/>
    <dbReference type="GeneID" id="87867935"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042186347" description="GLEYA adhesin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="45602" checksum="A5993A38AB88DE14" modified="2024-05-29" version="1">MKQALFLVSGFAWLNLASAACCRSNKCLKAIVLNEHGIDDCASVLIETVIVTEIVTVSSTQYATVLGTEIVTEIESTTAATETVFFTESSSVTIGTETVSQLTTETTIASTETVFQTITVPAPTEKKRDIDTLTFVEPTSSAPVEPAPVQSSPALPEYALDCPSFDKYKSACKCVGAEVVTITVPVPVSTVTVEETTTVFASVAATVTTTETELVSVTATASATTTVLVKDVETVTATQTDIVFLTATVTAIETATAAPEPVQPVCLTNTDAFRAMTTFNGNTIYMYANLLNGISGNLNWLFGSTSTSASVQPRYNLALDSEGSLYFHDRVVPYTYTYYVYIGTLNSGSSWLQINDKQAVEGQIAAGAKVSKIKGCVNSVTGELTLQDSLGRKNILICGGQVWLSAGLGEDINRGTCYQQFPHVVAPYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MND2</accession>
    <name>A0AAE0MND2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_311416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677494.1">
        <property type="nucleotide sequence ID" value="XM_062823304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MND2"/>
    <dbReference type="GeneID" id="87860458"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="171"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="327" mass="37404" checksum="3FC7AC2762A5671D" modified="2024-05-29" version="1">MASGLPANPLKKINLVRIAHVYYKHKNIDEAKRFAEDFGFAQTAEVGKKTYFRGYGTEPFVLCLEASKEDEFGGAAFVVESMEDLMQAAKTLPNECKATEIYDLADAPGGGKCVTFYDPVDGFPFHLVYGQTPVEARDVDFPIVRFNFPNEKNRGANEFQRFKKRPAPVHKLGHFGVCVTDFATCYDFYAKYFNFFPSELVHNDEGVNKTVFFRLNRGNDLVDHHCFFFFEGPKMHVHHSSFETHDFDTQVLGHDWLRHQGYKNCWGVGRHVMGSQIFDYWFDPSGFILEHYVDGDLLDMNEPTHNTKAAPDNLHVWGPEVPATFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNH4</accession>
    <name>A0AAE0MNH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_292629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678542.1">
        <property type="nucleotide sequence ID" value="XM_062823030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNH4"/>
    <dbReference type="GeneID" id="87860184"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="212" mass="23727" checksum="0C728E05045980BF" modified="2024-05-29" version="1">MTSDSDCLSSTSLPSVNIQPVILRLNPTAVSCSHFSRDNGMWDGNLDGKEQTEHRQCHLEMGQTGGEAVPLTDAKAPNYEQGVNCLLQPFLPLLPASSFGTISQHQRHHQSKKALTIQRSRSFIQFTRLLQSPNLLSIRSQFHANPESQTPKTPISPSFPQFPNSPGLLQLAHSVVPSCRLTFRQLPTHPRMRHFRYRLLGLYKRDVPPGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNW1</accession>
    <name>A0AAE0MNW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_479475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678034.1">
        <property type="nucleotide sequence ID" value="XM_062827529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNW1"/>
    <dbReference type="GeneID" id="87864683"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="164" mass="18923" checksum="F5B1BC3FAB0B3CC9" modified="2024-05-29" version="1">MDDDSEDEDRSQPLVLAEPQPRPCAHCQIYGREDANSHEIRDCGYGSKLGDVPGCPLCNRMTHYYDGCRKRKRSPADRRHEDWKFLVEYRSGLPPVRTKMAWPDLVTNMQPTHGFPITKDMALQVRDNHRHGTQYHDPLTRTLGDVRKNLERLRASEVFTGMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNY0</accession>
    <name>A0AAE0MNY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_471109</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678992.1">
        <property type="nucleotide sequence ID" value="XM_062827078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNY0"/>
    <dbReference type="GeneID" id="87864232"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="92"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="279"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3340050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="425" mass="47359" checksum="7B231C3A77CB2F18" modified="2024-05-29" version="1">MSALGAGLQKQSWDMSALPKFEKSFYQEHPSVANRSAAEVDKFRADHSIAIFGSNVPKPVETFDEAGFPRYVMDEVKAQGFPAPTAIQSQGWPMALSGRDVVGIAETGSGKTLTYCLPAIVHINAQPLLAPGDGPIVLILAPTRELAVQIQQEISKFGKSSRIRNTCVYGGVPKGPQIRDLSRGVEVCIATPGRLIDMLESGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIIGQIRPDRQTLMWSATWPKEVRNLASDFLTDFIQVNIGSMDLAANHRITQIVEVVSESEKRDRMIKHLEKVMEGRENQNKILIFTGTKRVADDITRFLRQDGWPALSIHGDKQQNERDWVLDQFKTGKSPIMVATDVASRGIDVRNITHVLNYDYPNNSEDYIHRIGRTGRAGAKGTAITFFTTDSKCHLNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP91</accession>
    <name>A0AAE0MP91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_475346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678439.1">
        <property type="nucleotide sequence ID" value="XM_062827303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP91"/>
    <dbReference type="GeneID" id="87864457"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="143" mass="16118" checksum="33F5813C3A10161A" modified="2024-05-29" version="1">MTTPADLVPPPEGTLTTPQIDGIRIMRKTLLGSPSYDEVWQTLSMTSDAINLDVPSLLLWQEEGQKRRNALFYLIDEGEEAVAMEICQILLDAKDEETLQELVDATCFIHGEATTFRELAERKGYERILRMLERVGCLLSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPI3</accession>
    <name>A0AAE0MPI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_251753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679131.1">
        <property type="nucleotide sequence ID" value="XM_062822475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPI3"/>
    <dbReference type="GeneID" id="87859629"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="332" mass="34190" checksum="61D940AC7FB61170" modified="2024-05-29" version="1">MAAPQVKSSSELTMAVLGCGTMGISILSGILTSLTTLAASPSPPPTNPPALPRHFIATVRSPSSIHKVESALSPLVKPSVSTLRVLPSTSNVSAVAEADIILLGCKPYMVSGLLSAPGMKDALTVNHTSGHARKQKIIISICAGVTVPQLEQILREDVGLPADDLPIVVRAMPNTASKIRESMTVINTVDPPLPDSVTELLTWIFERIGEVVYLPPNLMDACTSLCASGTAFFALMMEAAADGGVAMGLPRAEATRMAAQTMRGAAGLVLEGEHPAILREKVSTPGGCTIGGLLVLEEGGVRGAVARAVREATVVASLLGGGGAKNVNGTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPI7</accession>
    <name>A0AAE0MPI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_550684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679146.1">
        <property type="nucleotide sequence ID" value="XM_062829758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPI7"/>
    <dbReference type="GeneID" id="87866912"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF9">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="480" mass="54201" checksum="75A014B5FD32B1B0" modified="2024-05-29" version="1">MLVLNANEAIHHGRGTINHQSITEFTNVDIVVWWEGGEGEPSNTMSPEIFGHSFTNSSDPNWVPEPGTRGTFSILSVCLVTLGLCVWTAIHLNVPEHKEPGWKQLMRKIGWLVFSLLSPEIIAYTAYQQYVQARSLVNTMNKQDNEHDSDSLSESDSLYHDGPPSNSKGLMDILVSWLHPGILATLAITTPSRGRRGDTVEKWTMVHGFLAVMGGIAIEIRDSDPKVDDADRMMNFLPAQEFTSVKWKRKRLTINKSQRQRTRLTLTPKGLQFLQENGHEMLIPDLSENRIKDKSKGSALAKTLVCIQASWFCVQCLTRFAQGLAISLLELNTLGHAICTLFNYALWWNKPLDIVEPETVLIHPSRKREELEKAKLIAAMCSASRLDKEASESDHLHFDGEMFAFPVHCGTKDGPDSHVDLSGRPLREKRYRLNMRDINPKERYKTRQGVTEDTHLDDEDTIILGPFFETMFHGGINANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPK9</accession>
    <name>A0AAE0MPK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_253486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679206.1">
        <property type="nucleotide sequence ID" value="XM_062822513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPK9"/>
    <dbReference type="GeneID" id="87859667"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="590" mass="65673" checksum="A1326EAA6B2C46DE" modified="2024-05-29" version="1">MDLIQAASGYVTKMVTVGENAGTAAAPSAKMKMLLLDKDTVPCISAAVTVSTLLNHEVYLTDRLDNPKREKMRHMRCLCFVRPHPDTIGLLIDELRDPKYGEYHLYFSNVVKKSALERLAEADDHEVVKVVQEYFMDYVVINTDLFSLNMSLPMNRIWSGNPDTWNTDSLQRCTEGVISILLSLKKKPLIRYQKSSPLAKKLASEVRYCMTQEDQLFDFRKVDTPPILLILDRREDPITPLLTQWTYQAMVHHLLGIHNGRVDLSDVPEIRAELKEIVLSQDQDPFFQKNMYLNFGDLGGNIKEYVSQYQSKTQNNANIESISDMKRFIEEYPEFRKLSGNVSKHVTLVSELSRRVGAQSLLEVSEVEQSLACNDNHAADLKNIQRLIQSPTVTPDNKVILVALYALRYSKSPSSQLPMLVDLLSAAGGVPTRRTDRVAKLLAYHSSLHATTGGSGSGVGGIADIFESSGIFGGAGNRFKVLKGVENVYTQHSPLLETTLQNLVKGKLREQQYPFVDGGGSTRDKPQDIIVFIIGGATYEEAKMVAEINASVPGVRVVLGGTTVHNAQSFLEEVEDAVGGWPEQVAQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPU9</accession>
    <name>A0AAE0MPU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_429994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062824855.1"/>
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    <dbReference type="Proteomes" id="UP001278500">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="29"/>
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            <begin position="41"/>
            <end position="62"/>
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    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
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            <begin position="103"/>
            <end position="220"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3340534.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="305" mass="33064" checksum="3C4B6C557D824DF3" modified="2024-05-29" version="1">MASLLYYPVYFLEGCVVLTIGFYMLSLVLPKAAFVARSLASYLSLLLCAGFGVFTSIAFSLLGHGQSAQWAVGRSFKYVMALTTGVRFKIEDPKNILGKTRPAVFIGNHQTELDVLMLGCMFPKYCSVTAKSSLRKTPFLGWFMSLSGSIFIDRASKTDARAAMAGAANQIQKKQQSVYMFPEGTRSYSKEPELLPFKKGAFHLAVQAQVPIVPVVVANYSHILNVKDLVFNAGVVPIKVLDPIDTTGLTTADVDELCKNTRDLMLKELIALTAKARGQSVSEVTGANNHPSVAKTSGTDMKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MPZ3_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">B0H65DRAFT_473158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062827184.1"/>
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    <dbReference type="GeneID" id="87864338"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="12"/>
            <end position="29"/>
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        </location>
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        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3340669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="87" mass="9766" checksum="5A91F22229455565" modified="2024-05-29" version="1">MPVSFATVPSRIWMPAMFLPFSFSLLVSVRMSRPFSRSLSPEWGFPNNTTHLTQTTGPGPSPGQAFSRLPPCHLRRQVLYHYVSSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR47</accession>
    <name>A0AAE0MR47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_510027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680841.1">
        <property type="nucleotide sequence ID" value="XM_062828363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR47"/>
    <dbReference type="GeneID" id="87865517"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="463"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3343048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120771" checksum="6B8B63C436B7C9E7" modified="2024-05-29" version="1">MPPAADLNGGVPAYRTGSGDGMRDRSHNNNNNNNNNNNDNDLPPFFPLQNQNQVQPQQRPKSSYLRSLMGHKRSNTVGAGLVQLPPAVFSTDFQKSSDRDRDPVISSSAASVIDPPELLRPPSKINPDLVAQRHSCDMNLSGYQRRQFADALGELQPNQLDDQPPRSPEKKSNPFATISLNPFGSKDSSKASKNKGDQSPTKPKKVKSAANIGQLLRPKSTKNLKQQQQEEEENSRRRNKDKENRAPSAIDTSPPPPIYAQFARGSPFAPPPGLSSSTTPVASPLDYRDPFWDSSKPLPADPERPGTGRSSIAENQHLKPEAENRDRDRNNSRSKPRPKSFHQYFASNNQQDEKRTPSDSSTDTRYRQPQSDNNNNQSSSQERQERSWKRQTWATAKGSDLAAGGSQGSDRSNQRYNVKSMFSSSGNGGGSSSSAGGERIKSAAAAAQSASMERQQSAQSLLQQHIDPKDIDKHLEAMLDRRNIPENQRYKMRNLNDTIKLEFIRQDWAEMQAKMVSQNASNTSLEKGGNAGSVNGGAGSEREDQQQQQQSSSSSKREDGNSKDKDNERTGRTKRKGFGLSLGKGAASKAQSSPSKSIGRHFRSKSNDSSMNERPSFGDLNGNSSGNGVGGFLGMKSGKSQQVPADFVAYLQKVRKPELVEVGKLHKLRLLLRNETVAWTEEFIKQGGMKEIVDLLHRIMAVEWREEHEDALLHENLLCLKALCTTALALQYLHTIHATLFPALLHLIFDPEKKGPSEFTTRNIITSILLTYIECATPQERITRAQTILQFLRDPETEEEKKPVEFILEMRRERPYRVWCKEAVSVTKEVFWIFLHNMNIVSLPPADPSLSGISGAGGGSGGIIIGEQKDTQQQQQLHQAGIIDPSALPRSDTDPHSGSGGEDSETATAAQLAYMSRHFPQERPPVPAAPYVGGVEWDATNYIASHLDLMNAIIACTGPTAAERNALRAQLRISGWERCLGGSLRMCKEKFYGSVHDGLRTWVAAAAEDGWDVRDVRFGPPPESRGVSPMKKTPGKKPREEAPPKIEIPKLDFHIGGANSPGIGGLGAGVVAGAVANINGGGGRSPMPVSPAVRAPDYWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR48</accession>
    <name>A0AAE0MR48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_426689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681197.1">
        <property type="nucleotide sequence ID" value="XM_062824646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR48"/>
    <dbReference type="GeneID" id="87861800"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="197" mass="21604" checksum="28643EE93D0A235C" modified="2024-05-29" version="1" fragment="single">NSLPIPAPRYSPPKDADGKPIFVPVQSKKTNGDKKPSTADFIRPPRDDEGNIVTLPLLAAASAASPKKKTKTKTVGAKKIEKKNNPRHVFFPGCIPGSQPGRVLWLQGLDYFAASRADLKAGGKTKGHGGSGRGRPPKHIRRQNAQKEEALAEKQCKFIEKSCPGVKYGEDEEGKERMGREAIVRRIKEQIIKGVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRH4</accession>
    <name>A0AAE0MRH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_573650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681618.1">
        <property type="nucleotide sequence ID" value="XM_062830554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRH4"/>
    <dbReference type="GeneID" id="87867708"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF9">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="67" mass="7357" checksum="AD5F88AD34E696D3" modified="2024-05-29" version="1" fragment="single">MGLIGQNISGHSFTNSSSPRLRWVTEPDIRGTFSILSTCIVTLVLCVWTAIHLNVPGHKEGAMKLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS90</accession>
    <name>A0AAE0MS90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_470586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062827048.1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3343167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="143" mass="15633" checksum="ED29D6A461EFB647" modified="2024-05-29" version="1">MGTACIGERVPDQFIIIYNLHLKYHQKTTSYHESTDKHQTYNNQTHTHKQSKMSVIRLSASALRPVAARRIAPVSRTAFNQTRSVSSNGDELGGVQGSEPATKPNRYNVRAGTITAIGVLAAGGYMLYKKGEEKNTSPLGASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MSF0_9PEZI</name>
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            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_507647</name>
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    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682668.1">
        <property type="nucleotide sequence ID" value="XM_062828156.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87865310"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="150"/>
        </location>
    </feature>
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        <location>
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            <end position="229"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3347586.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSZ0</accession>
    <name>A0AAE0MSZ0_9PEZI</name>
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            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683253.1">
        <property type="nucleotide sequence ID" value="XM_062824388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSZ0"/>
    <dbReference type="GeneID" id="87861542"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23310" checksum="E9F8FF6568CBFDB5" modified="2024-05-29" version="1">MMFAFWRFLEIITLIPTMGMLAYFVDGYVKANQLTPTYILILFIVSVLALAWSIATLFSYHRSSTNAQFVSFVDLAFVGAFIAAVYYLGWIGSVNCTSVDRGNPYFVDLGAVGSANFNTFRININKTCAMLKACFAFGIMNTIFFFITSLLAWIHGGHTARSEKVYHTTRKTTTHSHHHRGGSGHRRSHSGSHSRTRRSRSHSRSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTG2</accession>
    <name>A0AAE0MTG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_549261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682190.1">
        <property type="nucleotide sequence ID" value="XM_062829645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTG2"/>
    <dbReference type="GeneID" id="87866799"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042041201" description="CFEM domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="10">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3345577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="104" mass="10594" checksum="616BEAA5FCC63536" modified="2024-05-29" version="1">MQCTTIPITLLSSIAFTSARPQTGPPVASCPVTAQMPECGVPCISAAAIEIGCTKYMDFECQCKNAAAMQAAVMPCVAQARGAALAPVVGQVANAICEQCVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTS9</accession>
    <name>A0AAE0MTS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_149282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682535.1">
        <property type="nucleotide sequence ID" value="XM_062821056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTS9"/>
    <dbReference type="GeneID" id="87858210"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="343" mass="37183" checksum="0DCE7F76E258CC48" modified="2024-05-29" version="1">MAVRIALPRNTTSSFRRFVRVAGRFYSTEAPAGPIIRVTNLPAPNSGHIRILELNRPAARNAISRALLSSLRDEIDAVHSQYDASTGEEKPVASWNKRFGGVAGEDEKGPTRALIISSAVDTSFCAGADLKERKGFTQEETAAFLTSLRTALTSLQSLPIPTISAISSIALGGGLELALATHFRVLTSNAVVGLPETRLGIIPGAGGTYRLPQLIGIPRARDLILTGRRVSAPEAYFLGLADRLVEVAPESEEQAKEWAAMEQEPRDEMVLSLARRTALSEAVRLAQEICEGGPVAVRAALKAVQEPSEMVENDMYLRVVRTEDRDEALKAFAEKRKPVFKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTT1</accession>
    <name>A0AAE0MTT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydroxy-acid/6-phosphogluconate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_462734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683284.1">
        <property type="nucleotide sequence ID" value="XM_062826657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTT1"/>
    <dbReference type="GeneID" id="87863811"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="7">
        <location>
            <begin position="85"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="8">
        <location>
            <begin position="418"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3348202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="664" mass="70759" checksum="8A9D7651C79259D3" modified="2024-05-29" version="1">MASTSAPSPSEASAPTTDTHHTQSQNSPALNNNNKDYDLSTPIDPNNSVGGLRQNLTSYGDAHFSLFMRKLFIKAMGYSEDALSRPIIGIVNTYSSFNPCHANMPQLMDAVKRGVQLNGGLAIDFPTISLHESFASPTSMYLRNLMSMDTEEMILAQPVDAVVLIGGCDKTTPAQLMGGISANKPIIHLVTGPMMPGSFQGTRVGACTDCRNNWAKFRAGTLDMEDMAALNEELAPTSGTCGVMGTASTMACLLVALGLMPLSLPSATAPAVSSARLRVAEHTGALAVQLSQSQLKPQDLLTCESFLNAITVLQAIGGSTNAIVHLMAIINRHPSLAGTISLKTIDDIGRKTPLLVDLKPSGNNYMTDFHNAGGMLALLHQLRPLLHLDALTVTGRTLGEELDSIPFRPLPSGTELGQIIHPLSSPLYPSSSLIVFDPSISNLCPLGGAVIKASASKYRRLLQHRGQAVVFHGPADLARRIDSPDLNVTPDSVLILQHIGPVGLHSPGMPEAGMIPIPRKLALQGVEDMLRISDGRMSGTAGGTIVLHVSPEAADPESVLGVVRDGDWVVCDVEGRRLNVALSGEEIEKRKRERREGMKKGFSKEEEEKGNWQKREGMRGYRGLYMREVNQADEGADFGFLTAAGPKGKGKGEVKGEGGGEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUS1</accession>
    <name>A0AAE0MUS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_519329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684546.1">
        <property type="nucleotide sequence ID" value="XM_062828715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUS1"/>
    <dbReference type="GeneID" id="87865869"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="240" mass="25772" checksum="2846A2880DA10BFC" modified="2024-05-29" version="1">MAENNDTFTIAGGDIPVASSSATAQAEAQTQTTESSSDSQQPSVSPEEETLPFAPSLSTSVLLPLTPTTSSAPALTHVQRVWDSIRPNSAIYNLLLSDIVLVAAVSYPTGRILAHLTLNPVHLNSKRILHGAVSGTLCDWAGGMAIAASIAGDELKEGEKEGERKMTTGVSTDMHLSYCSTAREGDTLEVEAWVSRRGRKLGFTGFEIRKRVEGWERGERGEVVVCGSHTKYLPFGQKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVL4</accession>
    <name>A0AAE0MVL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_417733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685953.1">
        <property type="nucleotide sequence ID" value="XM_062824106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVL4"/>
    <dbReference type="GeneID" id="87861260"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="53"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="334" mass="37158" checksum="5EA0C279491B06A7" modified="2024-05-29" version="1">MPPPQSQRRQAVESDEDEDVHQRPDSPADDGNSDVDHMHGVERDETSQLIKKLVRYALACEYSRTPIRRDGIKERVLGVHGREFKKVFAGAQKQLRATFGMEMVELPTKDRNLLTVEQKRKATKSQSQKEPTSNSYMLVSGLPEHLRVPDIIAPSKVQSADGEAAYIGLYTMLISVITLSGGELSDPRLRRYLTRLNAAENMPSSNPNNENAPSEKTELVLQRMIKQGYLVRVADNKNAGDGDAITWHVGPRGKMEVDNEAIAAVVREVYGGGQQNEDLERKLQASLKVKDRKPPRSAAAGRAPATIQEDEEEEDAEEDDEPDPGPSTRRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVN2</accession>
    <name>A0AAE0MVN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_19602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686013.1">
        <property type="nucleotide sequence ID" value="XM_062821715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVN2"/>
    <dbReference type="GeneID" id="87858869"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="596" mass="62076" checksum="128831D12808F726" modified="2024-05-29" version="1">MLRRPLTVLTITAEDIASYDDRALERQKAREMAARTQARQDAMRRGHHGHHSQPLQQPQQPSAGARIFGREHPGVGNVGPSGGFGHGHGQGSGLGFGTSGGGGGGGGGGGARISEQYMGTGDEDEEEEESEEEEEEDAGDESYYAQRHAQRQARMMEQQQSAAQRHAAQRHAQQQQQQQQQQQGQGQAEERTTTTAGRRGGGTGTRAPQQATTAAGGGRQPHHQSRAAVTPTGPTTTATAVETPSAMLPGGAGGRRGLRGGTTTTRAGQLQQQTPAATGQYDGAQEADSEEEATQRIDQGYGYSWEMDLDINTHIPLISPSDDNNGSNGDNIRGMEMLPPYHLHGYGLHVESHEIQFHTPPVAAQSGNQVIATPTNQPPHAHQQQSQASQATTHSQHSHQTTHHNQQPQQPQPPHHTRTNTNTNNTNRRLSQSQNIPPPIPPTPVPRTTTTTTTTTTTTTTTPQPQQPAAQTPAQRVAAQQAQQRAAAQQQASALRAQRRRMAMEADEQEGLYARLTRGHASLSVASTSTAAVPASRVGSVSAVTPEGQVGTAGAGAGAGAGGGGGGGGGAAGGAGAGGGAGGGGRTTAAHGRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW61</accession>
    <name>A0AAE0MW61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_556523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685055.1">
        <property type="nucleotide sequence ID" value="XM_062830052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW61"/>
    <dbReference type="GeneID" id="87867206"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="147"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="263"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="354" mass="38394" checksum="033EA5A58C614EFB" modified="2024-05-29" version="1">MIKSSDAGLSPALVETVAGLSAGSMATLIVHPLDIVKTRMQVHRSSPTNPSAALTTVSVFRSLAQTDRPLAALYRGLTPNLIGNATSWASFFFFKSRFERLIAHLKAPPPSLPLAPSLPTSPLGESTLSQNVTTPKKETQAQIKSHLSPTDFFAASLLAGAATQIITNPIWVLKTRMLSTDRLAADAYPSMFSGAVRLFKSEGILGFYRGLGVGMLAVSHGAVQFAVYDPARRMYVASRDAKRRLRGEEVALDGESERISNEATIVLSTVAKLVAGTATYPLQVMRARLQHHLADELFGRGIGGVVAKLWREEGFRGFYRGMMPGVVRVLPATWVTFLVYENVKYYLPKMVGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWP5</accession>
    <name>A0AAE0MWP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_6840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685655.1">
        <property type="nucleotide sequence ID" value="XM_062831273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWP5"/>
    <dbReference type="GeneID" id="87868427"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="532"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3354277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="616" mass="66781" checksum="09580BE090C301F3" modified="2024-05-29" version="1">MAPRVIVVGGGLSGLSAAHTIYLSGGNVVVLDKQGFFGGNSTKATSGINGALTRTQVELGIQDSVKQFYDDTLKSARDKARPDLIKVLTYKSAAAVEWLQDVFNLDLTLVSRLGGHSQPRTHRGHDAKFPGMAITYALMQRLEELAETEPERVQIIKKARVTSLNKEGNKVTGVKYEVNGETQSLDGPVVLATGGYAADFTADSLLKKHRPDVYGLATTNGTHATGDGQKMVMAIGGNGIDMDKVQVHPTGLVDPKDPNSKWKFLAAEALRGEGGLLLNGDGDRFCDELGHRDYVSGMIHKEKDKGKYPIRLVLNSKASKALDFHTRHYSGRGLMKKMTGQELAKEIGCTPEHLQKTFQTYNAIAEGKQKDPWGKKFFHNLPVDINDDFHVSVMEPVLHFTMGGIEINDKAQVLNSEQKPFEGLYACGELAGGVHGANRLGGSSLLGCVVYGRVAGDSASSYLFQEALKGNTGAARLGQIALHIDPSQPGKISVQWGGESGAQATANTEAPKKDTAAAAPKKEDPKAFTIPDKEYTMEEVAKHNKKEDLWVVVKGVVLDLTNWLEEHPGGVQALLNFMGRDATEEFEMLHDDEVIPKYAPEQVIGRVKGQKVTLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX02</accession>
    <name>A0AAE0MX02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_584331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685925.1">
        <property type="nucleotide sequence ID" value="XM_062830893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX02"/>
    <dbReference type="GeneID" id="87868047"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="508" mass="54644" checksum="091B6FD5B2A6617D" modified="2024-05-29" version="1">MDELLVPFQHRNRHKSNEEIKQCPPIITPRTLLHADKYQLARLVFLIFSIRVTPRINNMAISHDPPSVLIGPGDFHTGPYYIIISGVSVLLSHNLLSLNLQASQLPERTSWQDVKDFIKSQIPWKLDIYVSIFGKRQDSGWVRVIGFKAFNHVRRVLGESLFRGREILAHNPGYDETGAGLVLVRAPFFRDRSLFINPEALADPTTTTVSVQAAEEYTTTTTTPIASNSPSEQSYPGTCGTTSGALLELPHGQQQSQTQGQGQAQTSPPPPDVQFPPTPPNTPKTSRSISEPSLSGFRKLAITWREEENPKPIVKPSPPSSAGPLSPSTQEKMGSQIKSELAPLLAPLLARGGGGPVDPLETLECFPGIALATFSSHELARRAIKVLRQSERLNARPVVDEVPELTEKGQRVKGGKKRGGKKGAAGRTVSAPAAAEAGAGAGAGAGAGVRGGDDEFQTSQGKDKETTTMGSRTVADDKTITSARGTATTTTATRKTPAVLIVNGSWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX26</accession>
    <name>A0AAE0MX26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_504690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686015.1">
        <property type="nucleotide sequence ID" value="XM_062827934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX26"/>
    <dbReference type="GeneID" id="87865088"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="483" mass="53022" checksum="C1599270D0522776" modified="2024-05-29" version="1">MSEIDPLVLSYSHLHHLPQPSSALHLLKKIASLVKPLMRARGWRVRELGEFYPEQENLLGLNINRGAKILLRLRYPSDKSLFLPVEQVTDTMLHELAHIVHGPHDGKFHALWNQLRDEHEGLVMKGYTGEGFLSEGRRLGGSSRGRIPMHEARRLAREQAEKRKVQTTLSAGSGQRLGGARPRPGEDIRRVIVEAVERRNKTLKGCGVKDTGDEGLGEYEIRRIEEQATRNGFRSQAEEDEANEAAIAQALWELVQEDEKKKFGSGYVEPSREFPAGSQGAFQQIEEKGGGSAASSSSAQPPPIPHHTKPTTIISSRPPPSVSSKPEPSNEPSTGWACNICTLHNPDTFLCCDACGTERPLRTSTTTTAPIPKKNTTGTSSSSSSRSAGKRPSSSVVDLTKSPPSIRTRPSQPSSHIRTGSGSGSGPNKDKEKAKAILQAQAEAEAARRKVLHEIWQCSFCGTRLEKQWWTCSTCGKMKDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXB8</accession>
    <name>A0AAE0MXB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_453089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687171.1">
        <property type="nucleotide sequence ID" value="XM_062826131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXB8"/>
    <dbReference type="GeneID" id="87863285"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3355793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39765" checksum="C46C592A6CDC6D79" modified="2024-05-29" version="1">MLLQMSAKAQICADLLRRTHRERKELYIKALEDEVLRLKEIFSTIAQDKERLAEENRRLKAKLAQNDAAGDPIAADTNFFDQMVSSPSGPSLGYTSRSSILGSGSYLPGPASSQTSAPGFPSPPPSTTMTSPVYRPPPGGPRDFNTILGDGAGVLAPKRNPDMDYDQAGIDFVLTLERPCMEHMTWLLERGAGTEDRAQRQPCGHALMASCPPEPFSELSPESPFGYANMPNLAIGGNSSGDGGANTPIGQQHVHAHAHGHPPMPTSISGGGQRTWELSKADLATLLDLSKRLDLDGEITPVMAWGMVLAHPRLAELQLEDFARLSEELGSKVRCYGFGAVMEEFEVRDALENLFSTEPDGGVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MY14</accession>
    <name>A0AAE0MY14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_564558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687065.1">
        <property type="nucleotide sequence ID" value="XM_062830258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MY14"/>
    <dbReference type="GeneID" id="87867412"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="373" mass="40622" checksum="BAB7913AB9F6F226" modified="2024-05-29" version="1">MAPGFSFGFAGDDIEDDGQPTSQVNSVAPPTPSAATSASAFPVQGKPLLPPTHHDIDHMLSRLPSKIAYSLLDVELEEGKTIQIPRRELWDVRVQLMAEDDGSNISETEPGLGEHDVKTGIYEGGFKSWESSVDLVKVLASENAPTILNRDPCVLMEIAFQLGCGTALPSLALFQWAMNERKSGEKQPLTLVLADYNPSVLYLVTLPNFLLAWALFQRESTPVLADAFSLEDEVELLPEVVEAFKEFLTSNQITLSFLSGGWSPEFIDLLYSSGIPSNPTGSVQTLVIGAETIYSPFALESFAATLLLILERERKERPSGHASSIVGAKKMYFGVGGSLDDFVDRMRGLGALVEPLREEAEGVRRGVVRCFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZV5</accession>
    <name>A0AAE0IZV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_534839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676527.1">
        <property type="nucleotide sequence ID" value="XM_062829015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZV5"/>
    <dbReference type="GeneID" id="87866169"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40523" checksum="60E11DD4FE1394CA" modified="2024-05-29" version="1">MSICFGAYLRELGRGQLWGHRVLSVCKLSKLPLSVCVTVDFGVAYPSSDHPRELIGIKADIWSLATAMFEIRFGFPPFGTNNHAPSSIPSMEESMGPVPHPFRATIREWYKFPAESEEELQGKSNSELSYIATNPEEMEKNRKFHMEERGAKDPMIFRILYPRSMNISPAQAEDIANQAKSNPAQLPLWTPIPPNPDRRAYYSRKDYLKFVPPKEEVEVFWDLDRPTIEQIMEQPWFEDRKERRVAAVKTDITTAEAGIAGSISTKLGQIKSHINNWFNILFWDEEKEKTKGPDFLWRYVWQPTFKAFDKISGVPTAIFWLLMIVPAAWVIKRRIDRGGNVFFPSSVRGLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZW0</accession>
    <name>A0AAE0IZW0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_481517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676484.1">
        <property type="nucleotide sequence ID" value="XM_062827631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZW0"/>
    <dbReference type="GeneID" id="87864785"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="181"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J092_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">B0H65DRAFT_436986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676635.1">
        <property type="nucleotide sequence ID" value="XM_062825276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J092"/>
    <dbReference type="GeneID" id="87862430"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="82" mass="9820" checksum="B8ACB794F9D5C999" modified="2024-05-29" version="1">MCFYYYKYLYCSEGANCVAGYGWVNRSGRTYVKEYRIEQYRKPCDNHGRGCTRLDYMGSDTKQSEDRCDDCKDYNRGRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0C1</accession>
    <name>A0AAE0J0C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_534492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676680.1">
        <property type="nucleotide sequence ID" value="XM_062829004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0C1"/>
    <dbReference type="GeneID" id="87866158"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="79142" checksum="51CFF1E6D5DADEEE" modified="2024-05-29" version="1">MTVHNESEGSQSPSNAAHKPPTKSYHEHRGEPLEGAALEECIESLIEGWTTCVDELSQLHTKAESASKPIRGLYTLLKVQQRTLDKLKAKKASQPSPPPSTESNEDGTEPKPLFTPAQYFGMRSCCWDERWSVIKKCRGLVAINKEFARSPKQPVPGGKGWLSYKDKPLLEKPIAVDAVIDSGATWLKFVSISPKTLAYQIAVDGWESDDEEEDDTAYSDDEDQQNGNGNGIAARNGVQEALGNTEFAESIKKVILAARWNHCHHLHLLLPGLRDGESEPVDRMLRYIREKIGGDDVSVTVSCADSPLLADAPPPLDTALAALVDERDPLVADDCGRITPTANLDPSVLVSLVTDLHHGLVDLQPEFQQRVIARSVSDHTTDSNELVPREDILAKVLYPALRGRKLVTTRLAARYFRQLIASISTHSEEVRASFILPPDAPPALLSPGGSSEPLSTASLTPEQRRAELQRWSAVPVPDDLLLPVQIVDDIELEQVSPLITEGKLPPMALGVAQDLSRLNRSVYLYGWVNRLTTITGHRGIERQICLSLATHWTPATDNYRGSENDAKNNEIPPDIWHRHLGGYLIHRDKPRDWKALIAGYEECKDGRIPSEVVRWTNPWTTWGRGISTYGLPDTKTWEGVGHADKQSFGRKLQTREERGQRNPGDEQDVDEEEEERQSKEEDEKKEEDEKIASPVDAHPPALTTTAISATPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0I5</accession>
    <name>A0AAE0J0I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_78062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676844.1">
        <property type="nucleotide sequence ID" value="XM_062831408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0I5"/>
    <dbReference type="GeneID" id="87868562"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="24224" checksum="FA7B932185377EDD" modified="2024-05-29" version="1">MNNGCRCIFRSSRVREASRNKANNDPGPDFRDLLQEPDMRMALFNFVLADMADKVLKKLRREDLSHHCTRHLAYCDSFSVGLKCSLTLHNNGHSQAAPGKRRKFEKIASLLLNITVSFDALAVRVMPESQSSPFPRVLQEDSSQQQDDKCVRHPYGPPTRLERAKRHGRHLTSPRPIITTHHTKDRKPIPNSHPDTSGVVSPFFSRTVASNVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1M5</accession>
    <name>A0AAE0J1M5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_583427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677191.1">
        <property type="nucleotide sequence ID" value="XM_062830881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1M5"/>
    <dbReference type="GeneID" id="87868035"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3335025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="192" mass="21331" checksum="1A5E95B8EE0399B1" modified="2024-05-29" version="1">MRFDTPKRVCWQLLGVKHVVSPGGAMDCWADVGGIASSELARTCHAITALGQIGKLLEWYGARWEDALSLGETFQMYSRDLMEMLRGKKQQMGQRQDGRIRMDREDGRTTSSINNTNNTNNTNIYINNININDNRIRDHIIGPNRSAVSGAPVAHNRSMFPPLLLSPSSSSHIVVVVVVVVRIANGRMSRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1Z2</accession>
    <name>A0AAE0J1Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_329611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676882.1">
        <property type="nucleotide sequence ID" value="XM_062823493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1Z2"/>
    <dbReference type="GeneID" id="87860647"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15556">
        <property type="entry name" value="PHD_MMD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058054">
        <property type="entry name" value="Znf_MS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="437"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="738"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3334716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="786" mass="87348" checksum="D02BC52598F978F3" modified="2024-05-29" version="1">MPTSRKRALQEADTSNNAQPPKEPSVLHRIRNMWQFANLFQFVLLFGKALKLDDSLDIEDLEAECLKPGSMVLQDIGLGILKFLSSHRGLTHDVFEEYTRRQFLAKAPEKNPFGTEDLPTKFADFDVFTKIRVLQQMSQLVMCTPERLRERTEEQKDMDQTNWRIEPYGWDSEDRTYFVLDDNRIYRLTEAPAPAPKPKKNTKKAKAVSRSSKRRRVSAAVSEDGDAGDEDSVTGQPDGPEDDDLGGMKWECLAVSLDEVRQFLATIQKSKDPNEKILREQIQDHLVPILEKQEESKKRKQLQREKELQALEKMAHAKRSSRIAGKLEQQKAEEQAREEERKRREEEAARRKEEQRQAKMERERERRLMSREERVKEREIRRLQAEEELAQLSEDSKSVGSGPGRMSERHRQAAIEKNRRALQELQDEEDDWIFDCICGVYGQVDDGTHSVACERCNVWQHSKCLGIAEKDAEQEDFHFICSSCRRSEAEKPQQPRVIKLKVNRHASSSPPPQQAVSGISQSPAGRSQLVVELEARATSGSSTDRSSEENPRSGSQDSPSGQQEAGTEPTNLPGEKEGAARPVTATGSVGHSPGRREMNPFSSPHPTLSPPNQSPGKLRAYDSIFDHSAPSPAVGREKSAHLREEGSLPVLPPPAGNGRWASPSKQPQRPSSPLGTKSSPAAGARIVSTPLPQLTPVQSDPHARNGVIDRSSPLPPARGGLSPTKHSPPVPPRHQVNGSASAGASPSGTGRAAPVFPPSAALAPSPQQQNLAPPMKPVKPVEPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6S1</accession>
    <name>A0AAE0J6S1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_445851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677370.1">
        <property type="nucleotide sequence ID" value="XM_062825772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6S1"/>
    <dbReference type="GeneID" id="87862926"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3337919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="102" mass="11564" checksum="C8A5AA707160AAFB" modified="2024-05-29" version="1">MFSQDDESAAYLMVSTGPLSRAVCYDCIPFLFAVFTIRSVFVDKLSTTIGRKSVDTCSPFSPNTHSHSMNVIWLLEFSSSQKRHHRLSTHITLRMSRYAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6W7</accession>
    <name>A0AAE0J6W7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_434879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677485.1">
        <property type="nucleotide sequence ID" value="XM_062825161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6W7"/>
    <dbReference type="GeneID" id="87862315"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="277"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="777" mass="88536" checksum="9BE089B07BFD0C57" modified="2024-05-29" version="1">MHVVDMDSAMSPNCPCQDGPLAKPSDAIRVTPHQLCDRCSTVVRKSAVLQECFRRLDEGDQRRQDWRRCEIFYHSQGVEELAKSSQAGCHICTIVHDSMTKSAAPIREHGPVLVKVGIEPLQDELIDNDSLSMRFGILTVEKWRYYRVQAGWKEEDGTALIYTGGPLEADHLFRYGCTRQLTVLTDMTDTHFLLPKEARGYHLSRGPSTEAPETFELARYWLEECIKNHAECNSHGLQISKSDELPTRLIDIGEGPGQLEPRLFYPSASASPTDLKYLTVSHSWHATGVTEKLTTENESKWLQGLPIEKLSPNFRDAMTITRRLGYRYLWIDSLCIIQDSREDWEREVPTMTNVYGRTTCNIAMVGQAGDEGCFRQRNPLAAFPCRLYEADGKQSRLYAFIEGSNRKFSRGPEEIVGSFPLLKRGWVVQEALLSPRTIFFGDQEVYFHCTKQTMSESWPVALDPHIRHFNPRFLGFSKVRGFREFGQIFEQSWKEKFKGAQFDIKDERRAAMAAKNFLKKSRQLRAMWNRFLLYYTDTSLTFTTDRLAAVVGLAEAVENYTGLTYIPQAGTFKEFLPLDLLWYRNFRSVDLLWRKSPTGTKAPSWSWAANEGDVLFDEKSWLEGSHDDFEYMGLLLNVSVPPALTSSPQGSRPEVVIKLKTLINRQTALGLGMREPPGFWVEYLPKARLQVVLDEPVQDGTTIFFVVVLRTRTWNNSGYDKHVSGLILVQKDPSVAQEIPGQTLHRRVGFFRIAEPANVGGILDFFAGCPKREICIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6Y8</accession>
    <name>A0AAE0J6Y8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_311007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677484.1">
        <property type="nucleotide sequence ID" value="XM_062823299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6Y8"/>
    <dbReference type="GeneID" id="87860453"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="284"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110559" checksum="F0D9B2E6AF37C780" modified="2024-05-29" version="1">MLPPSSPIAFPSSPPPATATATATAKRPRDSDAPKPAKPRALGGFLSDSDDDHVSLERSPKRRMLQHDIQADTQTTEPPLLSQLAIDEDPEEETERYERLFGTRTTASALPTTLLSDFLNTPSYRISTCSGKSIPLRERKPTEPVSYETMVAARSRTKEGRAKKSYYGIDIHELIDDATKEIAEAHKAAATTPITPPTNPDRPVRSVEEHTTNTKKHKKSLLWTEKYRARTFMDLVGDDLTNRQVLRWLKRWDPIVFPHAARSKPSRRHGAQGQPQQPEEEKPHRKILMLTGPPGLGKTTLAHVCARQAGYEVMEINASDDRSKDVVKGRIRTSLGTESVKTVENKKPETGKQQKIARPVCVVVDEVDGVVSGSGGSGEGGFVKALIDLVLLDQKNSSGAGASSAAGRKKKKGDDFRQMRPLILICNDVYHPSLRPLRQSGLAEIIHVGKPSVEAVVTRLKTVFEKEGIPCEKDAARKLCEAAWGMTSGIDAKRGAEGNAEGDLRGIMVVGEWVAGRLRATITSTPVLTRQWIDQNIVQDLAHGGGGARGLGRGGVKEIVNRIFQEGGGFPKPVLSQAEQPKYAKHEQPQANLGFSEQRKKYAMARLREMIDTSGEVDRIMTEIFSEYPNREFNDDSFLTKPDSAYEWMHFHDTCSTRLYSSQEWELGQYISQPPLACHHLFASPKRHQPQNTERKWGDVMEEAEAPPLPFSGPRANFEAHEAEKVNRAALQGLQGQLPPSLHRLFRSPEDISTHFLPYLVRLVSPDVKPVVVGGSDKSGAVASVRREGEKAMVRRAAQVLAEVGIALQKGKIEPDPTLGQQYRTQWVYRMEPDLDTLATFETAGALVLASQAPTRYAVRQVLDQELQKTMAMRENAARQARMNNGQTNSTFKPHAAASLNVMDLDANKENMAMLADQKEVKRDFFGRVIVERKKGVNALGEKNGDATAAAGGGDGKESRRKGRGDVAGDEKDIKVWVTYHEGINNAVRKPISLEEFMRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J781</accession>
    <name>A0AAE0J781_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_306132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677311.1">
        <property type="nucleotide sequence ID" value="XM_062823213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J781"/>
    <dbReference type="GeneID" id="87860367"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3337860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="463" mass="51756" checksum="3D0423E76DF853FD" modified="2024-05-29" version="1">MSYPGYPPYGQPPPPQGGGYYQQPPPQQHHQQPPYGAPPPHAQYNAYQQPPQGYGQPPPGPPPGQYGAPPPQPYGAPAHSPPPGPYGAPPPNASYYPPGPPQAGYGAPPPHGYGQQPYGAAPATPTAYPPQPYAVQYPPTPPSPGYGPAMTIPWNPDPDADRLRKAMKGWGTDEKELIRVLADKDPLQINLLRDAFQRRHRRELVADIKNETSSWFEEGLVMLARGPLLNDVHMLFNAMDGAGTNEDILNDILLRRSNADLKAIKAEFSRIFRRSLEDMVRGELSMKTERHFMIVLGATRAEDSAPVMKADIDRDVDDIYNATEGKIGTDEMRVCSILSLRNDNQIRAISYEYKQKYARDLDTVIQKQEFSGHMKNALLIQLRHGTDKYMLQARLLEDAMAGMGTKDRLLTSRLVRAHWDRDNMRNVRNAYEQRYKKKLAKRVMGETSGDYQRLLMALCGEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7I0</accession>
    <name>A0AAE0J7I0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_582021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677745.1">
        <property type="nucleotide sequence ID" value="XM_062830835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7I0"/>
    <dbReference type="GeneID" id="87867989"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="37288" checksum="296FAEC507519308" modified="2024-05-29" version="1">MDSQSVFPFFRLPAELRLEIYKHVWTVPEAEYVYQPNDRDYRLRLSVDYLTAQLSAIRKLGAISQRIRAEAYPEYFDHTQILLRYDTAWRNWFPLDDPGWDDRNRRALYIISSSYLLQTQARHVYLHWPARGKESSISMFEVGNSRMRARWQEELLNEQWALECVSRFKNLRSLDVHVDNGLVIHWKDHYWFQHVYEFDHPDPDHDHDYKKELKRLFYDDERRAKLIEALKTHHRKLEKAVVRTDLGDSRVVVVKLMDEHKAFKWWRRLKKDVAVLASQGPSTAKGEKEDTYVFKQHIGGLKLCWPRASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J989</accession>
    <name>A0AAE0J989_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_392681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678326.1">
        <property type="nucleotide sequence ID" value="XM_062823755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J989"/>
    <dbReference type="GeneID" id="87860909"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="53" mass="5757" checksum="26CA22F69290429B" modified="2024-05-29" version="1" fragment="single">TTNSFQGREGSISVVITGTKEGLSTGFVSDENRLNIILTRQKSGFLIVKDKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9F7</accession>
    <name>A0AAE0J9F7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_476278</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678735.1">
        <property type="nucleotide sequence ID" value="XM_062827353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9F7"/>
    <dbReference type="GeneID" id="87864507"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3339375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="72" mass="8361" checksum="F3EFFBE9189331B9" modified="2024-05-29" version="1">MESPHEHQQNLLLSRIITNVEKLNEAIVVMNKALQEINIQNMNIELVAQMFKNYQSNVLFHLEATDNLKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9S2</accession>
    <name>A0AAE0J9S2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_302978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678900.1">
        <property type="nucleotide sequence ID" value="XM_062823165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9S2"/>
    <dbReference type="GeneID" id="87860319"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="299" mass="32429" checksum="3204AC632B46B814" modified="2024-05-29" version="1">MTAAEPSSSTRAAQERSDNDGITAMQGAPLLPHQEKNGAVFQQQQAPVPFGYGTGTYQPFPQRIPGSEIAYSKRWHVVKLAFQTASLVCSAIIFGIGLALGTYAEQWGDPWAVDIIFAVDASAAGLAILWTVAEFLALYASKERRGIHPGAHVGVQLIIVLVASLGAGIGGVFAVDFTEEYDEDETAITNLLRGLMRTLFAFSIILWIIHFFLFVRACVETHTVNATNKARRITYVRVPVPVPMPMDQIPQNLVAGQHPIPPQQNMMYGGHYAPVAQQPSAFPSGSQHQPAVPPQGYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9T2</accession>
    <name>A0AAE0J9T2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_296313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678661.1">
        <property type="nucleotide sequence ID" value="XM_062823084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9T2"/>
    <dbReference type="GeneID" id="87860238"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3339301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="364" mass="39768" checksum="B0D0B213A47E8C2D" modified="2024-05-29" version="1">MASMLEFRTPGYNPYAVKYSPYYDSRLAVATAANYGIVGNGRLFCLGLSAAGVQCEKTFETNDAQYDLAWSEINENQLIVACGDGSIKLFDLGVENFPVMNFHEHKRETFSVCWNPVTKDSFISSSWDGTVKVWSPTRNASIKTLPIGCCTYSTSYCPSNPALISAVSGDSSLRIFDLRTPVSSKYHLTNVIPVHAPATGGQGYSRLVDGQIYSGTVPNEVLTHDWNKYNDTVIATAGVDKVIRTFDIRNPAGGPLALMTGHEYAVRRVAWSPHASDILVSASYDMSVRVWTDGSTMPQHVQPPVPSGRQPDTVRAGTQLGLMNRHTEFVTGVDWCLFGAGGWCASAGWDERVLLWDAASLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9U9</accession>
    <name>A0AAE0J9U9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_433439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678691.1">
        <property type="nucleotide sequence ID" value="XM_062825070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9U9"/>
    <dbReference type="GeneID" id="87862224"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="107" mass="12159" checksum="2C77235007007A6F" modified="2024-05-29" version="1" fragment="single">DKRELPAARLPHAPSAPGGGPQVPYPKHVWSPSGGWYAQPANWKKNTAVLGGVVFLITAAVWKLSAEKEYRHKMPEPGRFYPSRYWSRQIIEYERAQKENGTTQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA69</accession>
    <name>A0AAE0JA69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_251710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679125.1">
        <property type="nucleotide sequence ID" value="XM_062822472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA69"/>
    <dbReference type="GeneID" id="87859626"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="212" mass="23091" checksum="0B3079EF38A90D08" modified="2024-05-29" version="1">MDPTQSLRLPATDSRPPARPASGPPAVCPASTTTSHPQLINLALGPQPSCTPQAYLGKPARFSSRAGERESLTRPGRHEIGQGPCLLFFPSQDLGTPISLDMDFVADIVDSIETYPGVLLPGSIVLLCQQVCVLAFSLFLQLARHLPHSNKPRNPLCFATAAPVPDLLACLVESLALAKQVRRVSEKRIFGCRIYTYTFKRRPLISLPQLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA91</accession>
    <name>A0AAE0JA91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_444301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679225.1">
        <property type="nucleotide sequence ID" value="XM_062825675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA91"/>
    <dbReference type="GeneID" id="87862829"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="109" mass="11667" checksum="153F2DC167ABF95A" modified="2024-05-29" version="1">MTGTQMGGGGGGGGVWLSLFSSALSEAVMSDSGKFIYLSTQQNPKYPLAGFPLYLFLCSIFRSSSPLNLHDAVNQPNLLSTLVFGLVTQLRESDLVIYINLAVLPRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAC7</accession>
    <name>A0AAE0JAC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_255353</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679269.1">
        <property type="nucleotide sequence ID" value="XM_062822544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAC7"/>
    <dbReference type="GeneID" id="87859698"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="879"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="391"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="783"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3340327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1142" mass="125015" checksum="D134D5CF6E45D577" modified="2024-05-29" version="1">MTDHDHGLGLSGLRRIRQQPPPLRTGTLPSAPGSRKPSFGSAITRSASVSTMLDVHNNSIPLHSVPNSPSIAFTEDLSRFPSESLHSFSFAHQSEDLIHNRQNVLKRSIEFMKDRMGWSVASNTANAALASAQARVTGDVETQNMLDLLARAQLVGAGSLPNGAVTLSTGPLTGPAELSGENIFDKQFMVPRVASPEPLEDDDSIAPESPASQKTIGATKRQKEIDTSRPAKFSLGNDSEHSSRSTTNESGTTAQTSPSTSLRPGFLKRTMTDTEHAQMQQKLMDVMATPFLAVESGPQDHLSSPARQSFSSISSQPPAISSAVHGHSTRWAPAAQAIFTTESKPPWTILAANDLACLLFGVTKAEVRKMGILEVVQGERRAWLERKLLQGSSDDAGDGSESEIVKPVSPPPMSSILGSRGGGITAKLLSKPNSRNQPPKSNAGRRAATIHNGDPKPPKPGQGHHPASQSRGVLLCGDVVPIQKRNGATGSASLWVKEKKVGLIWVLEEIHEDVAYLTLDEEGIVLKLSGALGPIWGDENLKPGMDVGKLIPRIPRQGFDPRTGDIDYAQIAKRRYYTCRNSDKINIPATIDQVRGQSELRVASFPHIAGIVVVDPQTFTIKSSNSVFCGALFGHEKPDGLPISHLVPDFAGVIRILTDEDGIDLVDGIVVPEHSFRKAAAFLALKEGRPDAATSLLRPEGLPAKHRDGSELKIDIQMRVVKSEKQTQISDQAIVEESEDEESVSGADMTDSFTVSQSELVYALWITYSRHLHATKNNLGSASPLLSGTATPLHQPSPGQTPAHTPPKMDSDSSSESESETPSQRRESATSLITRQLKEVAMTAAAKLTGTPKAVEPKKEDIQTPKPVEPPTKKTIDDFVILEDMGQGAYGQVKLARYKNSGKKCVLKYVTKKRILVDTWTRDRRLGTVPLEIHVLDFLRREGFKHPNIVEMEDFFEDDINYYIEMVPHGLPGMDLFDYIELRTNMEEQECRSIFVQVVRAIHHLHTKALVVHRDIKDENVILDGEGQVKLIDFGSAAYIKSGPFDVFVGTIDYAAPEVLAGKPYGGKEQDIWALGILLYTIIYKENPFYSIDEIMDRDLRVPYVISDESIDLIRKMLDRDVSKRLTIEEVLAHPWCNMEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAE0</accession>
    <name>A0AAE0JAE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_430234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678976.1">
        <property type="nucleotide sequence ID" value="XM_062824868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAE0"/>
    <dbReference type="GeneID" id="87862022"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF2">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="97"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="346" mass="39201" checksum="575C983743F2E178" modified="2024-05-29" version="1">MAGDEDEPEARFHDPMPPGYVFVPKGDVYITKNCRKETHSAGQTVYVVVNKRRKPIGLRCPVSIVKAVQESEQATAAKRAEAVQKRDAAMEGGFEEALKRLYPNTPKESIQKIVSHALKKRSRRVGRSGTVQLDDKVKLAVRAHIRHEHTEYEQLLRKGKTREGARRKVYSKLKEVARLWGGRPAKSAGTKRKAEDDGDEVRITREGSKMRKRQKKEEGIKTAATGAKTARLKRGMIERKKARKRMTREERQLLAEESRTSKVSGLRVQTRRMAREGIEPLGGTEEEPIIIDDSDGQDAVFTRGEDTDFDDGNESDWSNWSDISFGNATGKKSQQNDHHWTKPCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAN0</accession>
    <name>A0AAE0JAN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_552186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678817.1">
        <property type="nucleotide sequence ID" value="XM_062829872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAN0"/>
    <dbReference type="GeneID" id="87867026"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3339457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="101" mass="11038" checksum="396C177E6C0181B9" modified="2024-05-29" version="1">MSAAFEKAVADSKKLTSKPSNDDLLEIYALYKVATGADFSKADKPGMFDLKGKAKYNAWSKIVDEALTAEEAQTKYVAKVEEMKTTYGYDENKAPEAVGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB68</accession>
    <name>A0AAE0JB68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_578631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679710.1">
        <property type="nucleotide sequence ID" value="XM_062830738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB68"/>
    <dbReference type="GeneID" id="87867892"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="191" mass="21964" checksum="6C15E136D3B34560" modified="2024-05-29" version="1" fragment="single">GLSDVLQSAVPPTIDFFKSLPTLPNDALVWGIYALVFEKEDQLPKLYIGSGTESKIGLRDRFRDYNRGDFTDLPSKCLKKGWTEKHRGLLCWSSIPPEIDIPLQRLRFLAIEATLAFAFSVVRNRPQKTDDVWSEIVPWPQATFPWAPLCTHSAFWEVPRGIDKINITSEELEERKAMQAQRKYCLTCHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB98</accession>
    <name>A0AAE0JB98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_274656</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679827.1">
        <property type="nucleotide sequence ID" value="XM_062822796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB98"/>
    <dbReference type="GeneID" id="87859950"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="46"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3340885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="667" mass="72686" checksum="6269EB8D1ACEFB08" modified="2024-05-29" version="1">MLSEVIAGSLAELAKRDEEDPGADNPTKQEMYSAMAIFIFILLLMTAFFTSYIMQERKIQAVHETVVSIFAGPLPGMVVGLVIRISGSDNIQSLLSFSPQIFFNLLLPPIILSSGYELHQANFFRNIGTILTFAFAGTAISAVVIGVLLWLYTRIPLEGLEVTFREAIQVGASLSATDPVTILAIFNSFKVDPQLYTVIFGESILNDAIAIVIFESAQHAEGNGQRIGVVSIIHGIWYFLKEFFGSLAIGSVVGILAAVLLKFTYLRRYPKMESCMIVLIAYSTYFFSQAIQMSGIVSLLFCGITLKHYAYFNMSRRTQLTTKFFFQVLAQLSENFIFIYLGLSLFTEKNLVYQPLLIIVTVLSVCAARWLAVFPLSRLINWFIRYRARRHGRDAADVLPYNYQAMLFWAGLRGAVGVALAAAFTGKSRFALQATVLVVVVLTVIIFGGTTARMLEILEIKTGVVEEIDSDDEFDIEAIHGGTWHKRSGTGIGFSAPRRGSTVPLGNLDSERNGSPGGRSGWASGHRSPNPMPRRQSSRLDVKNGNDLERVDLLGVSGNNTDSEIGSDIDTSDLPPPAPRRRPSPIPGGGDADLEAGPGERGSGWNRSTSNNEGGQGLSATAAIRQLFSSEDPSALFRQFDENYIKPKLLLDGGTGRGGHGGPSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC15</accession>
    <name>A0AAE0JC15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_430908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679846.1">
        <property type="nucleotide sequence ID" value="XM_062824911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC15"/>
    <dbReference type="GeneID" id="87862065"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF80">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042172401" evidence="1">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="396" mass="41288" checksum="AC4A7F4BEC4491CA" modified="2024-05-29" version="1">MPSLISALTTGLLLASGIHAVPQGPFGAESGIVSAVPTASASTAGVAAAQPTTASASSSNAASDISACNNSPLLCDRAYNNVTYMGAHDSSFLRDASTGNSLAGNQYFNATVALDAGIRLLQGQVHDANGTLHLCHTSCTLLDAGPLEDWLAKVKFWMDNNPNEVVTILLVNSDNKLVSDYAAVFEGSGISIYGYQPSDGSTASTTWPTLGNMITSNKRLVTFIASIDYSPTYPYLLNEFDHVFETPYNVLSLSGFNCTLDRPSGQGSAGNAISAGMMPLMNHFADSLIMQGVQIPDETDIDITNSADTTTTGNLGLHADTCVKQWGTKPVFILVDFFDHGPAIDTADRLNGITATGRKSVSGEGKKSTSGAGENHSPMGINVALVAFVGFALAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCA1</accession>
    <name>A0AAE0JCA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_468158</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680199.1">
        <property type="nucleotide sequence ID" value="XM_062826946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCA1"/>
    <dbReference type="GeneID" id="87864100"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.486.10:FF:000011">
        <property type="entry name" value="ATP-depentend DNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="13"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="293"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="842"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="925"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="842"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1083"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3342406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1122" mass="121834" checksum="EF1096FC51F58A98" modified="2024-05-29" version="1">MSPSAPPKHSILDSLNNAQARAVTSDAATVAILAGPGSGKTHTLTSRVVWLVDHVGYQPQDVVVATFTVKAAREMKERIGKALGNGREKKIILGTFHSIGRRYLAAYGRHIGLSEKFSIADDNDSRSIITRICKRLQLGLDPPMAKAWISKKKAKGMEPSPSSVPQPPKKQPIQQGQRDLEVCYKEYQSHLERSNLLDYDDLLVRCVELLRKFPSCVSNIQTVLIDEYQDTNGVQYELMRLLAQRHQRITIVGDPDQSIYGWRSAEIKNLWRLLRDYPKTDEISLEENYRSSQAILDLSLLVIQQDKKRYQKVLKPVHDRGSRPVLRKLKNASTEAEWIVAEIRRALLMSGSMLTYNDVAILLRSASLSRHVESALGKAGVPYRMVGGFKFYERAEIKTVLDYLRVIHQPDNNDAIGRIMNVPKRGIGDGTIKNLIEEAEKSTLSLFSLLVKHCRGDRTAKTKITKHAEQKISGELIRMLNGIRKKMEEATESKPFGLVDLIEHLLTALNFQNYLQVTYPDDHEQRWANVQEFISLANDFVRDLDRSGEDALPEIEGLEQSKEEEVLPQFLANVSLASDAQKGEEGQESKPLVTISTIHAAKGLEWPIVFIPAVYNGSIPHMRSDDGDEERRLLYVAMTRAQSLLYLSYPVYSSPGSSERTELSSFVSPVANSFAKKGPNFERSLMRHIAKVLQRELPSEKDIFKGIPNMSHTEDNMYPIDPDENLQESGQGFDPSRSKRPKLYNPVAISTGDGHEEPQWAKPHATTMDQASTFTMASLPGFVNAAVHQAAITAAANASAAAALEARANKASASSGIKRGTNKRPADQKSILGFVKTNFEPATGSGSAITSTSTSITTNRPSAPTPRLPQPSLSRNPSLPTTRALTGHGLQRAQSHPSKPSVPIAGIAAGIAPELASHKLGTSRGLNLNVTRPPSLQPPKDSSASSFHYKKQYVCFSSSPTRPEPDDFAAPTTGSGEREEEEEENEQPPTPTRPAGSLHVTTCHNVLPTGLGGYPGRRAGGGGGVGGGAAGAGAGVVRKPVGLARLGGTEGMGAGMGMGGIKPMERLMKPFKPLTMNRAVGSGVSGGGGRGIGGSGNGSRSVGGGSGSTMGRPGVQRPGMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCM7</accession>
    <name>A0AAE0JCM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_218088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680188.1">
        <property type="nucleotide sequence ID" value="XM_062822011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCM7"/>
    <dbReference type="GeneID" id="87859165"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="492" mass="54978" checksum="84E4512112CFCD94" modified="2024-05-29" version="1">MDMIDPSSAATVNPPYDVPSLSTTTTITVNDAALVNSNVINGPGALPSELYHPATSSSLKRRNTDGGCPRGRRRGHAFPSLEIFSEYHGFGDIAPVGYSSWEEGDTQEHMHGDTMPFDPEGYYSPPYSKSELLELCANNPRADREDCEETDASFFSRAMIFDSLTGGDPMAYTGKQDIFTYNNVSSCDNVLTKECEVMFADNKSTTADEYSVASSDEDAMVKLADSLPSLLAQIPPSSVIKAVEGSSTPEIFDPSLQRSTPHSNPKSSSVPEKDNQPAESENLLDEDIDWDEVFQHLPAAPKDVNTSQILEFQNNTSQPLENTIEWMQSRSISPAKYQPFTRPAFPCPLRNKSPVEGLSNTNVLRTCFRLGSIFKEVAQCFRQDQEVTFELFARVSYSSRENGSRVQHFQFVDLYEDQPPHLSGVLTGWKNDTILEKDSVLFLGETKNKMCRCMCRPRKAKKPEIGWDLEVLRIRLTDWEEIESVRSVVCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDN7</accession>
    <name>A0AAE0JDN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_527304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680731.1">
        <property type="nucleotide sequence ID" value="XM_062828875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDN7"/>
    <dbReference type="GeneID" id="87866029"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="109"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3342938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="697" mass="75926" checksum="4F4C56E862CFE05F" modified="2024-05-29" version="1">MANTGPGNVPLHFIQKPPFTVEDPNAQPIPGETIPRRHPKAKDGLITRPAPGVNTTLDLLTRTVELYGDERAIGSRKLIKLHKDIKKVPKVVDGETVMVDKEWQYFELTPYSYITYGEYFTIVKQIGAGLRKLGLEPKDRLHIFATTSPQWLGMSHAASSQSLTIVTAYDTLGESGVEHSLIQSKASAMFTDPHLLKTATNPLKKATSVKVVIYNNHTTQPVSQDKIDAFKAEHPDLTVHSFEELRALGEENPVPLTPPSPEDTYCIMYTSGSTGPPKGVPVSHAGFVAAVAGLYAVMEESVTHRDRVLAYLPLAHIFELVLENLGVFVGGTLGYSSPRTLSDTSMRNCPGDMRAFKPTIMVGVPQVWETVKKGVEGKVNSAGALTKALFWGAYNIKSFLVSNNLPGQTIFDDLVFGQVRTMTGGDLRFIVNGASGIAASTQHFMSMVVAPMLNGYGLTETCGNGALGSPMQWTSTAIGATPAAIEMKLVSIPELNYHTDTTPPQGEILFRGACVIKEYYENPEETAKAITPDGWFKTGDIGEIDANGHLRVIDRVKNLVKLQGGEYIALEKLEAVYRGAVFVQNIMVHGDSANPRPIAVVVPNEKALSEKARELGLDAEAPSEMHRNRKLRDAVLKELQSVGRRAGLSGMETVAGVVLVDDEWTPVNGLVTATQKVNRRAVKEKYKKEITDCLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE01</accession>
    <name>A0AAE0JE01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_181251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681237.1">
        <property type="nucleotide sequence ID" value="XM_062821508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE01"/>
    <dbReference type="GeneID" id="87858662"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="116" mass="12933" checksum="45F49AEBD6404D36" modified="2024-05-29" version="1">MLPKGILAGIAFCLFFLSLLFTATLHPIIWVFGGFIPYLMCEISRESERELGLRHEDHVLITCTVTPGAAAGDHISGGQWIYKWELNGWERALMGRRGTFRAGSAGRGRKRKGKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE98</accession>
    <name>A0AAE0JE98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_184229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681360.1">
        <property type="nucleotide sequence ID" value="XM_062821548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE98"/>
    <dbReference type="GeneID" id="87858702"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="84" mass="9179" checksum="A6166FF7F6125B3D" modified="2024-05-29" version="1">MPAKIKPSCLVGAVWCVSGGCGLWLIRGVGVRIGSRQTSRPNEDFKKMKLEAGPVRSRSEEQLGVRTVPDMDLYGSPYSRIVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEP9</accession>
    <name>A0AAE0JEP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_550281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680902.1">
        <property type="nucleotide sequence ID" value="XM_062829719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEP9"/>
    <dbReference type="GeneID" id="87866873"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3343109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="251" mass="27951" checksum="5F85404BEFE18E2F" modified="2024-05-29" version="1">MSRRYDSRTTIFSPEGRLYQVEYALEAISHAGTAIGILAKDGIVLAAERKVTSKLLEQDTSAEKLYILNDNMICAVAGMTADANILINYARQAAQRYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGWDPQRQFQLYLSNPSGNYGGWKATSAGANNASAQSLLKQDYKEDCTLKEACAMAVKVLSKTMDSTKLSPEKIEFATVGQTKDGKIYHRLWSADEITALLKEHDLAKDDNTEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFE9</accession>
    <name>A0AAE0JFE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_509085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681974.1">
        <property type="nucleotide sequence ID" value="XM_062828279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFE9"/>
    <dbReference type="GeneID" id="87865433"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="82973" checksum="72A7D160E67B7C62" modified="2024-05-29" version="1">MSHPYSDNLYSYPGLGNDEDIEEAAGPQQDQRQIQNVSLPIDDFINNTSESSFNSPFSPPPLDEDPSLDPSMTGDSKAREAARLSGRDEDIYDADEGETTHQSSRIDGGYPSLPVSSSTYATPSAHSQPHQAAYYPHFPSQADSSSSPYIPPTSGSPYAAYPQHHQSTSSQGSSPFLFEAPPAYTPSPTSASPTSPLNSHAASSTTYQTFPQATTPPSSSTDSMGRPDESTGLLNRGPESMGNPGDGPENTNPTWTERARNRLPSRETVRKTLLALIVAVLLLGIVTPSSNSDHNNNPSSPSRPGHGDGRGGSSPSTPPVMQYPDVDNESDWFSRYRCRGGRTITRPTETYDVSFSSSKHLTINQERLDDGDTHHYDTYVQIQGEVIVRRSGKDTPDPSIVLDVIVNDDRIPIETHWNPSDQALTIKTPDGLNTGERNLKLCATVKATVWVPEDAELNYLQIATIHLGVQLLDNLSLTVKTLARFDAVVGNIISASSGASKNNNKEVPRDTSPDSYTFHPRKCEAGTTSGQIYGVWPLFDSLTLKSTSGDIKVGIEPHDNWDKDSMSAPQSAELSIRSASGDLDFREHGVSVTGKTPPQVPKRDYILDVHTTSGNVHGLAAFRSYATVKSTSGTLKLGLLPVLKSAEDDHPVEVSTSSTSGSTTITIFDPVYFSSSSQVATTPNPAFRNLYNQHTSTSGDFHLYLPSSWEGEIVMTSLSGKLAVAGKDVQIIKSGEQWPGFNKELVAKKGSEGSRVRVGLTSGSGEVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFL2</accession>
    <name>A0AAE0JFL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_206622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682064.1">
        <property type="nucleotide sequence ID" value="XM_062821873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFL2"/>
    <dbReference type="GeneID" id="87859027"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042030125" evidence="2">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="123" mass="13642" checksum="A777CB09554EA9B9" modified="2024-05-29" version="1">MIWVPHNCFRLFQFFHLLLKSLAMELRTEGPQPKGMDNEPVKATVQPVSATVWGHTNLSPETGLASLLRACITTKSSPKVILLNHDNETSKPPFSKRSNSHSHAGASRRPPAPPELILTNPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFN7</accession>
    <name>A0AAE0JFN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P115 like vesicle tethering protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_426423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681908.1">
        <property type="nucleotide sequence ID" value="XM_062824631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFN7"/>
    <dbReference type="GeneID" id="87861785"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="340"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1125"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1132"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3345295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129506" checksum="F4284C2C92445411" modified="2024-05-29" version="1">MFSTITAAPAKQSVSETIAVLSGRLNTATLLEDRRAAILGLRSFSKQYPASVASGALRSLIGSLSRDGEDVDTVKVVLETLLMLFSPNEDSPEASEEIALWLADEFTQRQENITLLLDLLDTTDFYSRLYSLQLLSHIHFARTERTEECVLVAPLGIPRLVAVLDDGREAVRDAAISLLIDLTAESVDIQKLVAFEKGFERIFDIITNEGGLVEGARVVEDCLILLANLLRLNSSNQSNVREMGFIARLAQLLRSAYKGSTDEEEVAQWAEEQRNRNIYALLALIRLFLVPGAAGTPANQIAFLNDRVLENTLQLGFTYGVDLPIRVEALAACADMIRGNARLQERFAGQEVPSPLAMNGQGPHSNGVPKVYVIDGLLDLILAVNSLMEFDLRMAACNCLKAYFNNHEEIRKHFLTRAIQGHKMQADELTNIFTTLLQPVPEQVTADPYRYWFAAMLMLHLVHELPTTKHLAMEVTEGDEASGEEVVTSIQTVASHLLRSVARNDDPRVIIGYLMLLLCWLFEDLDAVNDFLGEFTNLQGLIQAAVENPNGDIIVQGLSAMLIGVVYEFSTKDSPVPRAKVREMVMSRMGRDRYVDKLTRLRSYPLMRDYEILPQRLDLSLDQKLPDVYLDDTFVEFFKDNYSRIIRAIDRDPGLEISVITNGVQKGISRELVDSLRAQLEEKDRALEDFAAEKARLTSQLGQEQADHRRTKEQTAADVHRANEAIEHMRVQLGAKDHAIQNIEALVATLKQNLAKEQAEHQRSRAEAARLKTVNDGLQRAHEQELNKLAKDLRTKEDESRKLLEAARREAKNKEDELAKQHATQIESLKRDHQTKLESYQRDHATKESQLLAQIETARKTAEQETERAAQRFEAEKADLKATISRMEVDLMKANKAKTESQNKMTELETALQKSGDALSTAEKKLAEAEKAAKVTGEKLEELERKLKGVEEEREGVERTLKEKEDAVAEVERTLKEKEGEMVSMRERLLEGMEKEKEEAVQKAVEEVRKEIDSSLKVNDKTDAAATEAEKAAAIEAATTAKASEIEKRLQKEKEDALASVRKQLEKEREEAVAKAVAKAVTEAVEKEVKEKLDEELKNAQSERDDLLLLFDDLEEKRQKYKEQLKKLGGEVSEDEVEDDEEEEEDGDGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFQ7</accession>
    <name>A0AAE0JFQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_206534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682059.1">
        <property type="nucleotide sequence ID" value="XM_062821872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFQ7"/>
    <dbReference type="GeneID" id="87859026"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="445" mass="49401" checksum="25884F49A50764E8" modified="2024-05-29" version="1">MAPVTRSRRETKTTESPANKKSKTSTPKSDSKKPEKRKATEDATPVAAKKQKATKDAVAAPSPKPTPKTEKSTPKTTPKEEKKSTQKPVKENKKEKKEKPAQKEKKTKEPTPAEPEAQEKEDDNEEEEELDNETQALVKNLDGDDDNEEDTEEASKQISTFKKGQDVGKIPKKKTKDDNDASVTKGSGKRGVMYLGRIPHGFYEHEIRAYFGQFGDITRLRVVRNKKTGASRHRAFVEFAEAEVADIAARTMDKYLLFGHILTAKVVPQAQVHKDLFKGANRRFKVIPWNQMAGKQLEKALPESKWQGKITKEEQRRAARAAKLAEMDYEWEAPQLKAAEAKEPALLTAAEEEPVKAIEAPAAAEEKTEEKAEPEAETKEEAKEEESKEEEEPKSTRKRAAVTPKKAAATPKKAAGTTPKKAAATPKAEATTPARATRSTRKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG88</accession>
    <name>A0AAE0JG88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_467535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682347.1">
        <property type="nucleotide sequence ID" value="XM_062826911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG88"/>
    <dbReference type="GeneID" id="87864065"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3345734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="205" mass="22899" checksum="DCB9F4626C1E681B" modified="2024-05-29" version="1">MPRTIVTKVARATSRSLQTVRNTRITPTPFAAASVLPRTTVPRFFSTAGPNGNMITPDKQPVQPKEDAAPSVVRAATELTDDEYHKLADLYMDRLVTHLEELQDEREDIDVEYSAGVLTVSFDDGIGTYVINKQPPNKQIWLSSPKSGPKRYDYVALGDGQNEKEGTAKGEWVYLRDNSTINQLFRDELQIDLSMPVGHYGEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGN7</accession>
    <name>A0AAE0JGN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_203581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681967.1">
        <property type="nucleotide sequence ID" value="XM_062821834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGN7"/>
    <dbReference type="GeneID" id="87858988"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3345354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="851" mass="93635" checksum="DDB240A10AC6CB27" modified="2024-05-29" version="1">MGNDNSNRGSRAFVPGPTSTMTFHTPFPLLQEAQRQYHVCGSPYESPHSSSDSGYGSAPPTPITPHKKRTLIEADYLWRLGDGNLSDQENFSESDDKNTSDQEYKPEAYNDKERRPAALGTEAVDIECPDNESPRKRHKPATLPRSSPRSRPPLLSFFVSDSGSKIPRRSSKISQSRGIPDRFIPSRTLSSNTVEKFRTSKSPHELTIPEKLLRHNSATEDAFSNHRRVVATSTFDFNTRSRSDRAASRNRVGNVLGPVNTNAGHGRDRQFSLGSIWAVGGLAPPAETAVNNGRGHLMRSGTNARLFRTSFPTIKPKVEEELERHEARLATALGLDRAARVLDVNIIPHQSESKEKRSNKSHTQWNGTEWVKEGSFPKQQKKKQENRSLPAAPFKVLDAPNLRDDFYCSILSYSATCRTLAVGLGDLLYGWSESRGVRLLNAGTQDDCHLTSVAFSSTDGHKAILAYGRSNKTLGLMSLLDDADPATSRAAPTPRFEVLHPSPIACLSWKPSCTMRPSSCPSKPGVLVATEDLLVGDEAGRVWYYSVEWPDRWEVERHNWQGQLTLLARIDVHSQQICGLSWSPAGDRFATGGNDNLCCLFETQKVLDMNYARRNMGRVRHTEVSHHSHTQGDSESSSATEVATEIRTTPRPASVIPVLKPGDERYRWMHRAAVKAIAFCPWQEGLVATGGGSNDKCIHFFHTTSGAALATISVAAQVTSLIWSTTRREIAATFGYAQPEHSVRIAVFSWPDCRQVAAIPWVGEHRALYAIPYPGGPNDARKSGNSGGRARGSSRTAMEGCIMVASSDKSVKFHEVWTADKKATTGGVGMLGGSDILESLEGIDREGDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGZ3</accession>
    <name>A0AAE0JGZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_521533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682558.1">
        <property type="nucleotide sequence ID" value="XM_062828753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGZ3"/>
    <dbReference type="GeneID" id="87865907"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041917410" evidence="9">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="528" mass="57348" checksum="EF0742AF2C85C88D" modified="2024-05-29" version="1">MKYSIPVSRLVLVASLFGRILSIPSAGDDIHRVHARNHLPRLMDIPIHVDDSETEAPKAVVALEDDGRSALEGQTPSRDTGGRVEAESMTLAARGDTSAIQAQTAATSTATEVEEVVIYVDENSQTVTTETNTIPIISQATPSASSSSLSPSPSSSSSTSSSMAETTLKLKTKRTNLSSYLSYNKAHKKLIKPIKPTKPMDSTPPATNNTTILTNTNTTTHIHPGFSPQRLPGITYAPYDLTGCRSPSNIASDFSRIARTGLYSTVRIYGVDCSQVLHTLRAASSVSPPLKLFLGIFHLSDLSSQITTLVKDVQTFAAASSSPKKTVEEVWTNMVDTISVGNELVNNGQATPAQVLAAVRTVRQALRREGYQGPVVTVDTFVAVLAHPQLCSSPDTDYCAVNVHPFFDPHTVAGQAGNFVRRQVLNIREATNPKTQATTEKEGKQKRVVVTETGWPKQGNANYKAVPGRAEQKRAVEGVMKVWKEGRERGFGDDGDFEVYMFTAFDDEWKVAEKGTFYAEQFWGIQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH17</accession>
    <name>A0AAE0JH17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_587473</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682588.1">
        <property type="nucleotide sequence ID" value="XM_062830975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH17"/>
    <dbReference type="GeneID" id="87868129"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3347506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="539" mass="60269" checksum="3C484467AEBC7DA9" modified="2024-05-29" version="1">MAFGAAHLQLWLGALVVLGAVYTSCLIFYRLFLHPLAKYPGPFLAKLTDGYMAYHAFKGDRHLEFWRMHEKYGKFVRFGPNSLSVNSNTALKDIYGFKANVRKAEFYDAFVHPAPNTHNARDRDLHARKRRVLAHAFSDSAVKEVERYILSNIRTFCDAIGDLGRSSFAPLADKKGWSSPKNMSDWCNWLAMDILGDLCFGKAFHMLEHPDNRYAVDLVSVAAHRHLICGTMPMLDKLSLDRVFLRKIASGRAQYMAYSRQQLAERTALGDETDRRDFFYHLLKARDPETGQGFTTPELWGESNLLIIAGSDTTSTAMAATLFYLVRNPTAIARVTAEIRSRFASVEDIHQGPSLQSCTYLRACIDEAMRLSPSVGGLLPREVLPGGITIDGEHVPQGTIVGVPHYTIHHNAAYYPDPWSYTPERWLPTSSSTPSEKVPGTTTDDQLHLAQSAFCPFSIGPRGCIGKGLAYIEMSITLARVLFLYDLRRAVGVEDPAEGGKDGAEYGRHRVGEMQLVDTFTSTKEGVMVEFRRREDIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH53</accession>
    <name>A0AAE0JH53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_490447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682486.1">
        <property type="nucleotide sequence ID" value="XM_062827730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH53"/>
    <dbReference type="GeneID" id="87864884"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000722">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="484" mass="53487" checksum="0CE4596CA5ACB90D" modified="2024-05-29" version="1">MAHSVEETDLDKEKQLDGVQVSRNNEFTPEFEYSQAEERALLRKQDLTILPLCAAIYFLCYLDRSNIGNARILNSSTHNDMQTETHSTQYQFNIALMVFLVAYATFEVPSNILLKKLRPSRWIAFLMFSWGAITMGLGGVQSFHALAAVRFILGASEAGLFPGLVYYLTFWYKSDERSVRVASILASATLAGAFGGAIAYGIGHMNGASGLSAWRWLFIIEGAPSCLSSLFVLFFLPDYPEEHLKGREREIALARLKVEGSKRHHRSMTWQDAKTTLSDWRLYGHYLIYFGVSVPFSSLSLFTPSITAGLGYKDLRAQLMSVPPYAVAYVTQIVVSWSADRFNARGIHCAVFALIGAVGFIALVTLPVDAYQHRYGCLILASAGSFACVPPMLGWLSSNVYSTASVGLAIAINVSVGGGIGQIPGVWIYKKEEAARGYPTGHWTNAGMLLMVAAGAAGLRVWYGYKNRRLLRESNGQEVRLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH66</accession>
    <name>A0AAE0JH66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_424773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682857.1">
        <property type="nucleotide sequence ID" value="XM_062824529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH66"/>
    <dbReference type="GeneID" id="87861683"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3347775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="496" mass="56292" checksum="1EAF881F7333F456" modified="2024-05-29" version="1">MALLSLGFGNLMALAIASACLYVFGYAIYNLYLHPLAKYPGPLLMRATRLGYCQKLLQGTLSFDLLELHKQYGDVVRVAPNELAFANAQAWKDIMGHRTGPGGDFEKWDKFYRPVEGVTTDIVNAGREEHGMLRRTMAHGFSDRSMRDQQPLIKGYIDLLMQRLRENCDNGNKAVDVAAWYNFTTFDVIGDLAFGESFGCLEKSKYHSWVKNLFKMASGGTIFQAMSHYPPLMKLMLALVPKSLMEEHEKHTENAKDKLRRRMEMGQDRADLIEGLLKRKDEWGLTIDKLQANSAILVIGGSETTATLLAGATFLLATSPVALKKLTEEIRSSFNSEDEIDYASVSVLPYLLACLDEALRMYPPVPTGLPRVVPKGGASIAGHFIPEDSIVAVHHWAMYHNDKHFKDPFTFHPERWLNDPAFENDHKEAFQPFHIGARNCLGKNLAYLEMRIILARLLWNFDLKITEDSVDWMKKQKIFNFWDKGALNVYLTPRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH75</accession>
    <name>A0AAE0JH75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_460897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682673.1">
        <property type="nucleotide sequence ID" value="XM_062826567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH75"/>
    <dbReference type="GeneID" id="87863721"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="352" mass="38781" checksum="BC6707776C5C71D6" modified="2024-05-29" version="1">MSSSISRVIFNNKCPACKKLYTRHHRSCGTQSHRRNRNNKVADGLQSDDLSTPSGSSPRFDGTHEADYQPHGGSDSVLVGERGDNIRPPAGKLIEIRSSSSPGTHGGTAACQTVARAASIPYDKGGPLSRVPSDGLGLGLLDWRFIVTILPADQPSYVSPLRHASDYLPRNRTCVWNRHRLSQHLLEASHDASLLLSDKQKAAELANKLVDRNDYQLQAKVTYRCSVLLRLKGDIKGSEGIIRSFFSMASSVIDTVAEEDLARLYLSQANNYAYHLMFENAHEEMRRVRSWVRHEESSLLWEHILCVGRVMRGDGDFVGSRAVGEEARCCPRGHGWCDERGAAGGFPVAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHF8</accession>
    <name>A0AAE0JHF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_507880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682979.1">
        <property type="nucleotide sequence ID" value="XM_062828180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHF8"/>
    <dbReference type="GeneID" id="87865334"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="435" mass="47753" checksum="0AB9268225100A17" modified="2024-05-29" version="1">MAPRDPRVKQRGGSISQASQPNPATQDSIEVNTTEKVRSKVVAGRTEKPKPKPQDARTHEANQERAYVAASRRSDRSLEARLQSARLASEIHKKRTGKGFKITTEAVLNDAMYEEEEEPRTARLPYATGNFQNFALEQHYQRVNAQFAEAFPTLLQPPAMPLVPQYMPMPQQRTMSMMSMNSAPSYGLPPNHGMQQFRERTQSVPNIPLVSANSANSTSPGMPHGFGQRTQSLPVVPPISTNSPTLSVSHRPAGSHTRNSSMSEFSPPPALTPSVGDGTPPLPGLLTPTFGHENFDSSTTMQPRYRQSSVTSTSDAPLTPQSAMSVLQPTQAGHSAALPKASTDGVNQLASEPQFYPSYVDGSFEHFDDLYNSLSQQPLDLDESRSFYPSFAQQDENAPMFFQSQTEKPKEPDTEPDPLVNNDHDTFVDWNGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI30</accession>
    <name>A0AAE0JI30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microtubule associated-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_411624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683143.1">
        <property type="nucleotide sequence ID" value="XM_062823840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI30"/>
    <dbReference type="GeneID" id="87860994"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="4">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3348061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="223" mass="24446" checksum="13A677F86C056EFC" modified="2024-05-29" version="1" fragment="single">MVQPGVEGLGTPRTAVGDATFLDRQPDFDLSQELSFHSPSKDANIAQQLRNGNRPNLSTPRGTRAPFTNRRNVQANGNINVGGPEFTPLLKSATRNSARRLPGKENGRTTPNFLERIDEDITPLPKLNTSVYSSHTPLPNDATVSSTEVTTPITIRRRGGAKGPLDDGNQLSLREQENVVNKIEKENFGLKLKIHFLEEALRKAGPGFSEAALKENTELKVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI49</accession>
    <name>A0AAE0JI49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_165370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683168.1">
        <property type="nucleotide sequence ID" value="XM_062821290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI49"/>
    <dbReference type="GeneID" id="87858444"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001371">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1236"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1238"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3348086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1275" mass="143810" checksum="96BF43F2C1A8DB24" modified="2024-05-29" version="1">MDTNGAAGAGADPVIPRIHEALNIVHSPYSPNQARQEAQAFLEEVKTRGDAPSHGFSLASGGSQEPVVRHYGLSLLEYAVKHKWSEYDTNQREFLRGWILQLAQGVAKPDPPFLRTKIAQLWVEIAKRCWGADWMDMDELLNRLWQVPNSPVHKEFVLLILEILSEEIFNGEDAIVAHREGALSKGCVEIFTPSAVLSEAFPTRQHEPQVRFGDDGWISRVTELVRDCLNENLDSNEDVRACVVKALAVLNSVMPWAIPKAIHATGCRPVICNGLANSNVTVQRAALEALHSLYSRSAFSSEEFVDLVVPMYSPELVDLCRRLFEWSTVDAEDIDDDKYQFAKKFSEMISCVGNYLDRKYAFIPPQVDIQDFLKLLIAVVQSQSLVVSIPVLVTWTRLLNHRSLGPAIGKTDMVLPLLDVCSARLLRYENLPEDTEDPTFVLLMEDTDTIPERHAFLGNYRRYSCSIIESIIQLRLTDAFQYILNQAENALQTLYEGQLPLNPATYSKTSMPVLRVDAHATVIEAALKGYVKWRARQGELPGGEQEVSSIETHLEQWCSRLLEMNIEDPLIRKRILQLLVAFSTTALDTKANFMLRVLEHILMTWPALQPEHKTFNDAIRDLQTESMVELQRLASKMPDHLLDVYDQLEIKVKEMIASGTLDEKRQIAYRSFLFIIIHRATRIDQETRVRRLAEFVEPVKNQWKEAPLQQALGSFEGFCQLIGLDKAQNYIAQRRVHQVGDWGAADLDAEGLALQAELEQRQTFLPLRSTKSFLTYSVEKLEKNSPAYQASCALWQDGFPIILPELLKFLSYAHACHDPKNWSLLPEEMRPVVSRLLTDRFWQAGISEGSKDDFYARVLDKKNTLEGLASTIRGTVRFVREACYAVIYCMSRLDVQFYGFTELPGPLANALFADSFNLSSHQLINLLNLVRYLVDHCPVELRDHFLPPILAACFQQMDSKISSEWEKLGQKQTVQVADNDELTEEMKAESILRQLTYTAAIMVAEFLDPARTGPPSNLPASPNGTTPESRYPSLRRFCLMQTSIAGPLLLFLCHAIHMRDTRCCGVVLRVFRSIVPEFQIQSQPKEQKEPSHPLLPDENFPIPDATKAEIHQFLGTDVMRAAISSMNDPYFVDAQKDLATLIATILAHSCVGDEFSGGNSAPRQILCSLPGIKEQEVDRTLTFLRRPGTHSRQQRAVILDLLRNVKSVSISEMGKLKDPREDVVRKAPKRSKMAQKFMTPQQGVDTTVTGTEQGTGKRQATPDLEGVAGMFDEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIB4</accession>
    <name>A0AAE0JIB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_461988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683071.1">
        <property type="nucleotide sequence ID" value="XM_062826622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIB4"/>
    <dbReference type="GeneID" id="87863776"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042245834" description="Cytochrome b5 heme-binding domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="262"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="368" mass="38809" checksum="FFFD97E608228756" modified="2024-05-29" version="1">MALLGISLIVASVVLLVLRRPEWIQQFWTSLYRQASQNQLPRPPQRPIPRIEEPKPEDDQVNKKEKEKKRISTPEKVVSPPPPPVVIQENGITDNPDSPREEQTTPKASAAIPSDSVPAFTLSVPELPQQPKVEEEEPTPAVTSSTSTSTSTSTPSMMMPPPPVPARGGLSANLLRQPGTSTLPLPGGGPLPNRSSGGGSGPLPNRGPGGGGGLFPPPTHSTKPAKPSRAVVLTPGHSPLDWARLSGHPTADLRGLPKGTPYLRVTPSMLKKMTGRKGKDAWMVLGGRVYNITPYIPFHPGGELELLKGAGRDGTKLFGEIHPWVNYEGMLAACLVGISVSEEDGEAALAAAKNAGGGGGGGSMEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIK4</accession>
    <name>A0AAE0JIK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_175781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683519.1">
        <property type="nucleotide sequence ID" value="XM_062821439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIK4"/>
    <dbReference type="GeneID" id="87858593"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3348437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="371" mass="40221" checksum="6526410C02BF6286" modified="2024-05-29" version="1">MSAEKRPASDDPSRGQLVKRPNLGSSRALTRTSATGDSGALIQTAPRTSSLQAPVMELSGHSGEIFAAKFDPTGNLIASGSMDRSIMLWRTYGDCENYGILNGHKGAILDLQWSRDSEILFSASADMHLASWDLTSGTRIRRYVGHEEIVNSLDISRRGEDLLISGSDDGTIGIWDPRTKNAADYIETDFPITAVAISEAGNEIYSGGIDNDIKVWDVRKKAVVYSMIGHQDTVTTLRVSPDSQQLLSYAMDSTARTWDIRPFAPADRHIRTFDGAPLGMEQNLIKGSWDKDGKKIAVGAGDGTVVIWGSDTGKLLYKLPGHKGTVNVAEFSPGTDPLSKFIVVWLSFAVTNLVIVLSASSDRTMLLGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIL1</accession>
    <name>A0AAE0JIL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_178545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683635.1">
        <property type="nucleotide sequence ID" value="XM_062821477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIL1"/>
    <dbReference type="GeneID" id="87858631"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3348553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72024" checksum="1AD914B737AE4542" modified="2024-05-29" version="1">MATTTEANVNGEVVPVVEKLGELSVAEQEVVTFSSPSTSEASTPGTPETSVSSQPQYNFIPFEPHPGYPKSRISIVNRFIDQPREVRVAVIGGGLSGILAGVLLPAKVPNIKLTIYEKNHDFGGTWLENVYPGVRCDIPSHVYQSTFEPKLDWSDQFAGGAEIRDYWQGVAKKYNVYQYARFHTKVEGLNWNDSESVWEVTIKNLQTGETTTEKADSVITAIGRFNAWKLPDYPGIADYKGILRHASHWDSSFDPSGKAVAVIGNGASGIQLVANLQPSVARLDHYARNPTWIAASWAGDVRQAGPQPYSEEQIALFKSDPDAYLKFRKDMEDNYWRRFNAFFRGSKDSTELRERFTQIMHERLAKKPELIEHIAPDFSPNCRRLTPGPGYLEAISEPNVEYIRTRIRRFTETGIETEDGVERKVDAIFCATGANVSQVIPFPVVAKGKNLQDAWNPELKGKSDEHHGFPYTYLGVATPGFPNLFFLQGPHGTGPSGTVPHSTETQLTLLAKILRKVGREGIKSIVPSRKAADDFVEYSDAFFSSTVLTDNCSSWYNGGRPGARIHGIWPGSAGHLTAVRQNPRWEDWEYEYLGETGNRFQWYLGNGWTSREADPQSDMTPYLRRPGEKVELRDVHESWWNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIX1</accession>
    <name>A0AAE0JIX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_177066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683573.1">
        <property type="nucleotide sequence ID" value="XM_062821456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIX1"/>
    <dbReference type="GeneID" id="87858610"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="62"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="284" mass="32625" checksum="5E42EDF53FA3020B" modified="2024-05-29" version="1">MSSAKELNDVSLDSWETNASFWDDSIGKDGNIYWQKLQEPSLRRLLGDHLKRQHGQKPCLALDLATGNGLCARWLAKHGAKVYATDGSENMLQIARNWTRGKDWSENVRFWNLDVTRTEDFDVLIDAYFEDKFDIVLMNMAIMDVSTLEPLVRALPRLLKPNGVFVATVLHPVFMTSGASRNVDLRYDGETGDLEVVRTKVIKNYLHVPPYKGIAIPGQPKRQLYFHRPMDELFTTFFRAGLVMDAMEEPAFSEEDEEKSRVESSRNYTQLPAILSFRMRLPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJG7</accession>
    <name>A0AAE0JJG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dabb-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_463212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683452.1">
        <property type="nucleotide sequence ID" value="XM_062826687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJG7"/>
    <dbReference type="GeneID" id="87863841"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="110" mass="12638" checksum="5011BAF8D810478B" modified="2024-05-29" version="1">MGIVHVELFEFKPLATQEEVQEVCDRMMSLKDRCTHPKTHMPYLKTAVGGANVCPEGKQGRISHVFVSEFDTPEDRKFYLEEDPARREFVESIEGFVEGRQVVEFSPGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJK7</accession>
    <name>A0AAE0JJK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_567079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683776.1">
        <property type="nucleotide sequence ID" value="XM_062830348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJK7"/>
    <dbReference type="GeneID" id="87867502"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="275" mass="29871" checksum="D280FAADD7C9563D" modified="2024-05-29" version="1">MESSKDSTSTQKEPFQPKDEIAIEREPAMEFSKDSDAQEEPFPPAPKGEIAMEEAPAMESSEDSDSQKEPFLPAPKEEIAIEEALAIESSEDSDSEKELFPPAPKEEIAMEEAPAMESSKDSDSQKEPFPPQDDVFMEKTSVVEDAPVVEEVHVTEKAPPVMDKAPVMGTETPVAPKAPVVENAPVVGKAPLVEKASVMKETPIVGKVPFMEKVPVVPKATVPKKAPLMEKFKKEIRAIQNYQPSYDAAEAPSAAESAAMISVLFLSPCTSYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK16</accession>
    <name>A0AAE0JK16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_455932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684086.1">
        <property type="nucleotide sequence ID" value="XM_062826262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK16"/>
    <dbReference type="GeneID" id="87863416"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041917411" evidence="2">
        <location>
            <begin position="25"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="456" mass="49945" checksum="402A2718931545A8" modified="2024-05-29" version="1">MTSLTRRLGCLLGVLSLGTSLAHGQSITTINGQEVTMLTGTKAEHTTSSIPTNLYQTYTTRITLGTTTDTASTIIASVSDNGTDVSLTSESASETSSVTLSYLTGTKSDSTSTSNATASSTESPKPVPTNTRPCNNYPEFCDRKYSNITEVGCHNSPFVRANSAAANQQFPVVDQLNDGVRFLQAQIQWTANDSVPHFCHTTCDLFDAGPITDWLTTVKDWVVAHPYDVVTILLGNGNYSTPDFYVPHIEKTGILRYVFTPPVIPMALDDWPTLSHMILTGQRVVMFMDYMANQTAYPWLLDEFSQMWETPFDPVDQNFPCTVQRPPDLPADQAKNRIYLMNHNLNGEANLLGNVLSVPDLSRINVTNSAEGFGSLGLAANNCRSDWGRPPKVLNVDYYNMGDPPGSVFEAAARVNNVTYNRKCCGEEASSAERIEAMLKVPLTLGLMWAAFWTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKD8</accession>
    <name>A0AAE0JKD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein 12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_457247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684534.1">
        <property type="nucleotide sequence ID" value="XM_062826347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKD8"/>
    <dbReference type="GeneID" id="87863501"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="231" mass="27200" checksum="6618B76B13D8EACF" modified="2024-05-29" version="1">MERDPAFFAAPRPKKEGLIPPPKKRKTVHKVEEITFDKDARTEYLTGFHKRKQARIKAAKAQAEEEARLERIRLRKQIREERQKNLEEHIQTVHKLLHEAERAGTDDKTAEKKSDDEWDGISEDEVAEEPALDVEEEYIDEDRYTTVTVEAVSVDRDGIHKPRTLKDEEDSETEKNNKKKKAAEEAAQQEADKKSKRNFPEKKKKRKFTYESRHDRNVTERKQRAKKAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKG7</accession>
    <name>A0AAE0JKG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_457501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684612.1">
        <property type="nucleotide sequence ID" value="XM_062826355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKG7"/>
    <dbReference type="GeneID" id="87863509"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.150:FF:000004">
        <property type="entry name" value="Centromere/kinetochore protein zw10 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="2">
        <location>
            <begin position="694"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="857" mass="94032" checksum="09289175A47CD127" modified="2024-05-29" version="1">MAVATPDSPAGQIAQALVDFSVEGAFPEESVSSLTVDSDALPAAIEALASAKAKLQAEIHTINEETADDVRTWKTNAQSVQDDIIRSKALANDILKQSEAPQASGKAIEEAEARAAFLARELDYNTQLRSALKGIKAVNQILDQVEQARDERRILDALHLLERSWKELDAVPVNKSCRAIKLLDIRAFELKSDVHQVFDHVWNTLIHVDIEGHKVSISDTKQDEAMSLSDAVIGLKAYKEVDQRAAQLWHDIDKAILAPRLDIKQERLPSIRINENTLEIGGTSDQSIEAVFRDLEQIFAFLVEKLAPDLVETISTVLLPGLIPTITKTWLDLAVPSSLEEMDRFQATISTTKGFCTTLKALGLSHLNELQEWTESAPRVWLSKRREAALDQMRTQLSQGLGASKQVERVEKQVVSKSEGQQLAANGAMVTEDDGGWDAWGSDGEQETGGQQSSKPAATTSATEPSADAIDDAADAWGWGEEDPEPEKSEEPQQKKQKQEEDDDPTEAWGWGDDAQNDDTAPEPAPTAPSASSKPQTRELTFKETYSISSLPQPVLDLISSLVEDGAALTQGTYANSPVAAAAAGLFGLPTLALAMFRAVAPHYYAPDLGGNMFLYNDATYLSERLAEFAEEWVKRDNISTRAQTMLRLDNDIKSMQSFANRAYSNEMSIQKTVLRDLLGGEQNLIQQDDTESCVSAAVARVRSLAIAWESILSRSAWQQAVGSLVDAVANKIIGDVMDLPGIGQDEAYNIANHIASVTALDDLFLPSRFATESGNAGETNEIPTTAQYAGSWLRLKYLSEVLQSNLKDVRYLWLESELSLYFSADEVVDLVNLSFEDNPRTREVIREIRARPNPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKK2</accession>
    <name>A0AAE0JKK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_519533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684639.1">
        <property type="nucleotide sequence ID" value="XM_062828719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKK2"/>
    <dbReference type="GeneID" id="87865873"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="381" mass="44662" checksum="9823041D847E6CAB" modified="2024-05-29" version="1">MSTIRPLKGAFTSRLSLWARPSPHIAFRPHVSSHQPLSCARPYSDDQSREWGSLQDFFNDQIEKPKSHGKLHRSKQTKEARSTDDGEDEFSRILSPKQEKPKKPWLKKREESLARRDKDKAEERRRRKTARNIALLEQETSRRHAAGRPDITSAIDPERSEITPRTAKEAIARWQEMKGKDSQFQPKESRAVRALKRDVRREAKEARIFMASQAAEKAWEHEFEQIEKEKKPWNVKERVAKESLEKLKALDKLPREVPAQAQQNAVRTPEDPRENDSPEENPDEWEDELDDDAEWAGKKKPSKIERRRMKLLQRFKEGLQKKMGVPVGDTKPHPEIDAKCDAWLYNRIKAEEDRERRKKTRKAVAHKKFVSKLRRKAKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKS6</accession>
    <name>A0AAE0JKS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiol methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_419691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684734.1">
        <property type="nucleotide sequence ID" value="XM_062824229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKS6"/>
    <dbReference type="GeneID" id="87861383"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7829" checksum="52B09ED2D7EB593F" modified="2024-05-29" version="1">MDASNSTPTTQQTSSMASIQRSPVAAKIVPPQPAPAKTGNSTDAFLKDFTLVAEAAKRAQMAVMMRDFEDIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL17</accession>
    <name>A0AAE0JL17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_457491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684608.1">
        <property type="nucleotide sequence ID" value="XM_062826354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL17"/>
    <dbReference type="GeneID" id="87863508"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="363" mass="37943" checksum="0B3F2D81F220E725" modified="2024-05-29" version="1">MAPSTTAPTGPITTPLTTLLGIKHPIILAGMARVSGGLLAAAVSNAGGLGVIGGFMYTPDQLRSIIAEMKANFTRPDLPFGVDLALPQIGGSARKTNHDYTGGKLDELIDITIESGAKLFVSAVGVPPKRIIDKLHANGILVMNMVGHPKHAVKALELGVDMVCAQGGEGGGHTGDVANSVLIPSVVDVARTFKPQILNKVLGTTDHPALVVAAGGIADGRGLASSLMQGAAGVWVGTRFVASKEASCSEQHKEAVVTCGFQDTERTLVLSGRPLRMKTNGYIAKWHAQPEKIAELTGKGIVPIEWDMDQGNEIDPPHLMGQVAGLVKKVQPAGEIVEEMVQEAVEQLKLGQAYLNGDRASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLB2</accession>
    <name>A0AAE0JLB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clock-controlled protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_506868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684758.1">
        <property type="nucleotide sequence ID" value="XM_062828097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLB2"/>
    <dbReference type="GeneID" id="87865251"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042261789" description="Clock-controlled protein 6" evidence="1">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="13792" checksum="A8CDA3B127EED3F7" modified="2024-05-29" version="1">MKFSAAAVLAAAAGAHAWSNVTYTTEVVTAVTTYCPYATEISYGGTTYTVTEATTLTISDCPCTVTKPIITTSSVICHSCTGYVNSTVPAPTSAGSVGTGSAPAVVSPTVSPSDIPTAGAGKAAALSGAGLAGVLGLAAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLQ5</accession>
    <name>A0AAE0JLQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hsp90 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_507100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685016.1">
        <property type="nucleotide sequence ID" value="XM_062828113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLQ5"/>
    <dbReference type="GeneID" id="87865267"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="705" mass="80162" checksum="77330ACD2CB86E90" modified="2024-05-29" version="1">MSAPETFEFQAEISQLLSLIINTVYSNKEIFLRELVSNASDALDKIRYESLSDPSKLDSCKELRIDIIPNKENKTLTIKDTGIGMTKADLVNNLGTIARSGTKQFMEALTAGADISMIGQFGVGFYSAYLVADRVTVVSKHNDDEQYIWESSAGGTFTIRPDTEGEPLGRGTKIILHLKDEQLDYLNESRIKEVIKKHSEFISYPIYLHVQKEIEKEIPDEEAEEVTEEGEDKKPKIEEVDDEEEEKKKEKKVKKIKEVTVEEEELNKQKPIWTRNPQDITQEEYAAFYKSLSNDWEDHLGVKHFSVEGQLEFRAILFVPKRAPFDLFETKKTKSNIKLYVRRVFITDDATELVPEWLSFIKGVVDSEDLPLNLSRETLQQNKIMKVIKKNIVKKSIELFNEIAEDKEQFDKFYSAFSKNIKLGIHEDAQNRNALAKLLRFHSTKSGDEMVSLSDYVARMPEHQKNIYYITGESIKAVSKSPFLDALKEKNFEVLFLVDPIDEYAMTQLKEFEGKKLVDITKDFELEETEEEKKQREEEEKEYEGLAKALKNILGDKVEKVVVSHKLVGSPCAIRTGQFGWSANMERIMKAQALRDTSMSSYMSSKKTFEISPKSPIIKELKKKVEADGENDKTVKSIVQLLYETSLLVSGFTIEEPASFAERIHKLVSLGLNLDEEPEAAADAPAAAEGVPAAETGDSAMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM05</accession>
    <name>A0AAE0JM05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_587087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685183.1">
        <property type="nucleotide sequence ID" value="XM_062830962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM05"/>
    <dbReference type="GeneID" id="87868116"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042037753" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="133" mass="14385" checksum="898DC292D7E814ED" modified="2024-05-29" version="1">MHYLATALVAFALAHGGLADNEPPHIITYTGFQCTGEATSSVVGITGCVAPPPPEFRSYKENGWGPHHTRIGFYEEGTCRTQLFDTWAYDGDYFQSHQCYDVGSIAAHENPLGPMPISASGLLLKIVVDIGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM11</accession>
    <name>A0AAE0JM11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_547104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685424.1">
        <property type="nucleotide sequence ID" value="XM_062829489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM11"/>
    <dbReference type="GeneID" id="87866643"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="451" mass="49781" checksum="CE68DCD43E410271" modified="2024-05-29" version="1">MTGSSDRSTANDATATLTATSNAPNTTSAQRPSAVRDPAAEDSVETSTSAPAAAAPADEVANTTSNTVPDAPQQQASQAQQAQEAHEAPLLAPTTTHEQQATTAPSSSSYNGSHNDGHHGRHHGHHHDNIEAAGHDDASDSDEFSLTEGYETRSTGSTSATSSIYAHTYEHGRRYQSYKNSRYPIPNDDAELSREDMKHAMLLELLDGQLAFAPLGKNPQNILDIGTGTGIWAIDAGDRWPMARVRGMDISPVQPIWVPPNVDFLVDDCEQEWLMRGEVDYAHFRFMATVLKNLPVVLGHAMEALKPGGWIEFQELNCEVFCDDETMPADDPVKVLYDLTQQAFAKFNMNITMPKILKQYLADAGFVNIQCVVKKVPIGVWAKDKTLRLVGMYQKMAILEIMQALAGRPFDALGLDQVQKEMIMMEARKGLDNPRVHRYFNYYFWFAQKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM43</accession>
    <name>A0AAE0JM43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_124595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684832.1">
        <property type="nucleotide sequence ID" value="XM_062820725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM43"/>
    <dbReference type="GeneID" id="87857879"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="282" mass="30984" checksum="EE633B420969A256" modified="2024-05-29" version="1">MANIIDLDAEEAPKPRILVISLEYLESFDDIVSQFLTPMLELAIVQRVKKAATLTRLLSKEDAEPYSALVLTDAALTLPENLPLWEQVLAYLRRTGATAVLTGQVANFAIPDDLDEFFRVSGLPDWKGGMYQRNIVVMNEKADGIRDATHFDYRNKNGLKTMYSVKSLCLSGVRTEHRWYVPDANLDDGGGILNLPGMLARGPEGRDPERVHLQTAVAYGPVGEKGRIGWVGDVNSEEPSCKVILAMCGLDPAKASIEPYQSSTSGSAAMRWDAGQGRFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM93</accession>
    <name>A0AAE0JM93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_543541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685574.1">
        <property type="nucleotide sequence ID" value="XM_062829234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM93"/>
    <dbReference type="GeneID" id="87866388"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000483">
        <property type="entry name" value="Related to allantoate permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="78"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="529" mass="60070" checksum="593CE2481E5BAE47" modified="2024-05-29" version="1">MSEHDEPNVASPHRDIQQVDDKHGLEEVERTFSPDLDKGNQQRYDKVDKELAKYVADEAFEISEEENSRLRRLIDKRVLAIMITTYFIQAIDKGTLSFSSIMGIREDTGLHGQQYSWLTTCIYITILIVEYPQNYIIARVPIAKYLSFMIIAWGVVLACTALCKNFTGLVVVRTLLGLFESACQPAFVILSSIWYKREEQASRVTYWYMMNGAQQIVGGLLAYCFSLIKTGPLKSWQWLFLSYGIVSVLYGLFVGWWMPDSPMRAKCFSEEDKRLMVERVRSNQTGVQNRKFKKEQVYEALKDPQVWGYALVQLCTTLPTSGLGSFQGIIISSFGFSLLETQLLAMVLGFYIIMVLLGSVWIVKKTNQNLLTMLGFCIPSFIGTICLMTVPTDSKTQKIGLVICYYITLSFWSAQTLALSMLSRNVGGQTKKSVAVALNFIIWATGNAIGPQVFLDTDKPRYFFAFSTHLGCYSLLVVVIVGLRFYLVHQNKKRDELAAAGVQEARDAKMVHAFEDLTDKENPNFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMG5</accession>
    <name>A0AAE0JMG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_459933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685408.1">
        <property type="nucleotide sequence ID" value="XM_062826498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMG5"/>
    <dbReference type="GeneID" id="87863652"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="82483" checksum="B881B3B2A62DA991" modified="2024-05-29" version="1">MPRISFSSPIGSDGDIHEGNVQSDDSEFNESMDEIMQDQQEYYLEPASPQAAEYFPMLPEGFNQGDHEFQDRPEDDNPAVNAEFPHHHLTYTCYPMRAPDALRRNVLNPTSNAFLRPGSSQDFPDGLRLIFVNWLKKYDLNATTGVSVGLWRTVGPDPLLVVVKRIKGWKGRWRPDGYQQRIPNAGEVPGEIAYNNLPDPTGRTLKFSFLYHPHLTCLPQTHAFQLNNWPEENVTHFGKFYNGGQVEDLIERYKKQGKPIPEAMIWHVIAQVGRAYKFVHTGRTMPDKTQERGWVRGPPRRGREEQEWKAREEERAADWVPTAHCDGHSANIWLHFVTQYEREHDRENCLEHFDDYFPQVILGDFGLAVDRESNNSFCLMAEECPDLPDRESWKDKAEFGLTLHHMLLAGRRDLLRFTMQAIPEDWAEKWAEWLDANYSKTLIDVVKRFSHVAHLCDQNRLVGIVSFARLMERDYQRWKDGFPLLLGPCNEWFHHTMIDLADKEVDERRRFRDGVESVRWATGQRMSTMPYQVPNRTKYSRKITRPNAERPEDRQVAVPLDGRETLRSKARTIYTRKLRRPVTGAFFRHPPEPAHRVDKDKLWVSKTYRLERIRYRKPRDIKVESDLKGDLRREQTPFTPPPSPGEVEGIERTMFGPPGPWNSWVLQWDREGRGDGDESPTLKDWSRFGVNQNGGSSVSDEGLVNIPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMJ2</accession>
    <name>A0AAE0JMJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_447672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685615.1">
        <property type="nucleotide sequence ID" value="XM_062825875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMJ2"/>
    <dbReference type="GeneID" id="87863029"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="182" mass="19734" checksum="DAAD8423E3F815F2" modified="2024-05-29" version="1">MAPTVLPASGNPLVFFDITLGGEPLGRITFELFKDVVPKTAENFRQFCTGESKNNLGRPQGYKGSKFHRIIPNFMCQGGDFLNGDGTGSTCIYGTKSFADENFLLKHDSPGLLSMANAGPNTNGSQFFITTVPTPFLDGKHIVFGKVVDGMDVVRKMENTKTGYRGKDVPNLDVVIAQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN09</accession>
    <name>A0AAE0JN09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_514487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685979.1">
        <property type="nucleotide sequence ID" value="XM_062828644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN09"/>
    <dbReference type="GeneID" id="87865798"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="273" mass="28880" checksum="DD5E671855B09096" modified="2024-05-29" version="1">MATYPRQTSWIHDASTISLEAGNDGFNNAIDHVRPSGTQPSTGIRSHAYHEEIAQNHISIGEEGNGHQFDDEDDGTAGEGYLHANGNVEESVEDQDRPQSPIKDEEGKMRDQNGNDNETAASDHASAGNSPRENGGESSSHSGITPNRSFSKAHRNNSNSAELMLQGVSSRSPTPSQSPQSPETLSYNLGGYFQSCEDCFIAGLGCVHFTAAATIIMPDGRGSLIRDGGHGGHGDGKAARERHEWLVERMKESLAKINCAGGGGGGVVPRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNW4</accession>
    <name>A0AAE0JNW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_504972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686369.1">
        <property type="nucleotide sequence ID" value="XM_062827957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNW4"/>
    <dbReference type="GeneID" id="87865111"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000020">
        <property type="entry name" value="Oxysterol binding protein (Osh7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="529" mass="59310" checksum="D5C537B0507FFC93" modified="2024-05-29" version="1">MMGLVSGRRRATSTTSSRSSGDANQDVAEDDTTVVEPDQGNVLSHIISQLRPGADLSRVVLPTFILEPRSMLERITNFMCHPEMLLPIPEIDDPVQRFVAVVKFYLSGWHIRPPGVKKPLNPVLGEIFTCYWDFPDKTRGYYVSEQTSHHPPKSSYFYMVPGHNIRVDGTLKPRSKFLGNSAASMMEGIAILSLLNRGKDPQRGERYIITQPNMYARGILFGKMKYELGDHSYVRCPELDLVADVEFKTKGWVSGTYNAIGGTIRRESTGEILYELSGLWSEEMYLRDVKTGHKEMFFNALRAKASPPIARPIEEQEERESQKLWAATAKAVKERNHELATIEKTKIEDQQREEAAKRINDGVEWHPRLFRMVRGGPGGSEEGEEDLEWIINATIDGDTPEKQAEQIMAIYPIVKGQRFVEKNPIPPRSPIASPSKEAHSPVITADHEKLDHEEAGAEKEPVDTAPKVHPPLDPSHESTTEIQTLLVATGTVAKEGPLIDFHEDMAKDLPAIKKVDTGDSHDEFVDAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP24</accession>
    <name>A0AAE0JP24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leo1-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_450548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686425.1">
        <property type="nucleotide sequence ID" value="XM_062826011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP24"/>
    <dbReference type="GeneID" id="87863165"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="406" mass="46022" checksum="68A778B946DDD891" modified="2024-05-29" version="1">MSDSEDHIDNVPDDAGDDLFGDEDVNDDQPLSEIGEDKLSDRDLQSDREDEVADRHHDEVDGMEDEEPEFRSKTVADTPLYRHRIPKSGDGSLYSFKVPDFIKLNPIEYNADTWEPSKWDLRNARAETPIPTVMRRRDPKTGKMQSNTNIYRWSDGSVTMAVGDEHYEIQSKPLAPPSNKPYQEVQDAHYYAAAAHLTTNSLVIIGHFTEQYMLRPNKNIQDHALERLKAELATAKKERGPDMIILAKEDPELQKKQAEMAERERAKAQRRRETAAARVDGAGGRFKGGALSIGDLEGGRRGRKRGAPGGGKKKNRRPEYDSDDELPNGRGPTDKYDLDDGFLVDSDEESEEVEDDEEEEELLDDDDEEEEAPRRKRQRTAEADDEDGAGTTSHRRRRAIVDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPH6</accession>
    <name>A0AAE0JPH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_35953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
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        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
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        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="226"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="272"/>
            <end position="337"/>
        </location>
    </feature>
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        </location>
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            <begin position="273"/>
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    </feature>
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            <begin position="305"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00388"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3355090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823957.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87861111"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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        </location>
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            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3355557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="422" mass="49216" checksum="489972C6DE0E0264" modified="2024-05-29" version="1">MTIEEYDQYEQAYRDESDHEEYIRGNDINKENKAPSHSHSVPPTLRAPLANTFEEREERPLATVEREEPTVHTDLPDAIRSGSDTDTTDQMDRNEELQAQLAYLNRLADVNQTRIKELEIQQLAYNRQRRHIHRQDRWDYEDTFKDSQKKPEELIALIQASLQGLKKKITRDSKWTHKFNLDEKYNRQIQTEFYAGPIDDDSFIEPYPPRQSFQSIGVTAFEANVYTVCDRPWSPQAGDHPQVHPGHPSHGKIAWIQCLYDACPWHLSYKMEHDHFPQRVWENDVPIPVRTAHHKDSISMWDTCTPRKRDGGGRLMRLVLKDGYTRECMESPHTRYQDCCKINCAVHMADKARQWHSRQAMREERAFQRTQRKEETAVAASSSTSETASGSSSKSKSQRKRRARGGRRRQGNGASSSREDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPZ7</accession>
    <name>A0AAE0JPZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_536225</name>
    </gene>
    <organism evidence="7 8">
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062829039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPZ7"/>
    <dbReference type="GeneID" id="87866193"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3355587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="439" mass="47696" checksum="B791DF8C47C914F7" modified="2024-05-29" version="1">MDTLQHGARDLPWSSIPTDLLRAELSKRDDATDTSRPQCGSGEKGEYNTGLHVFALVLILLLSTLSCGFPLFSRRAMKGSKLQRKIIFFSQHFGTGVLMATAFVHLLPTAFMSLTDPCLPYFFSEGYKPLAGLVAMTAALVVVALESYLTTRGASHSHSHTIFEDEEENGHAHHGAEHGFKDSPERIALQDREVTQGLMGRQSPIASTSAQPSPSDQPRTSRDNDSANSLDLDLTFDELQPIPNTDHDQLLEPENTSSYRTGLKPAVAPDMPNPEEQKRMLLQCLLLEAGILFHSVFIGMALSVATGPPFIVFLIAIGFHQTFEGLALGTRIAAIHFPRSSPRPWLMVLAFGTTTPIGQAIGLLIHTFYDPMSQTGLLMVGFMNAISSGLLLFAGLVQLLAEDFLSEKSYATLHGRKRLHAYFAVVAGAGLMSAVGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQR6</accession>
    <name>A0AAE0JQR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_545027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687163.1">
        <property type="nucleotide sequence ID" value="XM_062829345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQR6"/>
    <dbReference type="GeneID" id="87866499"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="90" mass="9851" checksum="A1A7EC9AF6AD341B" modified="2024-05-29" version="1">MVPNNNRKAHSNKGKGKATYRKKYGPTPEEDAAVKAFFAKSPKRETQKAGEQSYQAADHETSKAKMENPLPLGNKGLAGSCFAKKEDPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQU6</accession>
    <name>A0AAE0JQU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_453017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687143.1">
        <property type="nucleotide sequence ID" value="XM_062826130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQU6"/>
    <dbReference type="GeneID" id="87863284"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000190">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="216"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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</entry>
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    <reference evidence="1" key="1">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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    </feature>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14179" checksum="4A59EB1AC8F1F067" modified="2024-05-29" version="1" fragment="single">ICQGVHVDDCAEGYVALAEWEVVNKVEGGGEVFNVSSRGTEETVDGIVKALCEEYGVDFERVRYVKPEDLQEGENPWPLELVVDFPQWTGDEKLRRVTGWRDRRPLFREAVGVYRRAYEAAKEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MJF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3334816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJF0"/>
    <dbReference type="GeneID" id="87860691"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP20-like_chaperone"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAK3334816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MJS6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676941.1">
        <property type="nucleotide sequence ID" value="XM_062823517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJS6"/>
    <dbReference type="GeneID" id="87860671"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042001635" evidence="1">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="198" mass="21619" checksum="1D58762F5333B311" modified="2024-05-29" version="1">MRTQLVFPALFAGLASAAGLESKSIYAVDAIKTIMPGALADCSSAQFPTECRTPEQAAPYLIKSFTGRTTGEIAMMLALIGLESGDLKYRVNLAHDDQGTANMMSPDFVKEYAQDLNLPIDGKSGAEILQLVISDDFRNFDSARWFVDKHCSADVKAKMKMGTDEGYNDYITKCVGTTMADARQQYWDRAKKAFGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMM2</accession>
    <name>A0AAE0MMM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_314108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677627.1">
        <property type="nucleotide sequence ID" value="XM_062823342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMM2"/>
    <dbReference type="GeneID" id="87860496"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="24061" checksum="93341BBF12CA43D1" modified="2024-05-29" version="1">MRLLIASRIHFSREPLHYSVSRCRIVVRLQLLFSIRFEATSKELPYEHILSSYQAPFSNLSSPVEQTKLKALGHDPIRKPNSMWTDVDIRLECNRPIPSPGPRLARPLRYGLGIDPLSRVSELCTGRTPLSAVLVRSQETTVSCFTHTCGSLSFFSFYTSTNLCDLCSRFCPPSLLPKCTVAYAVAVVTCGYLWPTPAGTRVADADHRRKYPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMT5</accession>
    <name>A0AAE0MMT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_478416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677733.1">
        <property type="nucleotide sequence ID" value="XM_062827481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMT5"/>
    <dbReference type="GeneID" id="87864635"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3338282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="375" mass="41268" checksum="38EA52481722CD42" modified="2024-05-29" version="1">MFLRKPLPTFTASTHFALPRHNPLRMATDDLSNKPLAVRTTSSTSTDSASSQDGASFDIVKTYRNLLTSDPDMTMPVAAIESLIELLRVTPSSTAMETVEVVKTQKALLLDSAPNPLPLLAGADLFEQYLLRSLRGQTAESFDETKRHLLKNRQLFAARAKAARDNIAVIGSRYISDRKIVLAAGGSRVVTKILVHAATSRPNTHFKVIYVMDGSPHCDASVSALREAGLEVETISTSKVAYILKDQKDINLVLVGSEVVMQNGGIISRMGTSQLALLTRFAGGSQKRFFVAAESHKIVRKTPLWHPQVLRVGVKQKDISKFDNVGVDPVGQEARDWVADRDEVDYTDPELIDGIVTEQGVKQPSQIWELVDYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MND6</accession>
    <name>A0AAE0MND6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_432727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678318.1">
        <property type="nucleotide sequence ID" value="XM_062825026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MND6"/>
    <dbReference type="GeneID" id="87862180"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="53" mass="6246" checksum="5418C3E4DCF735DB" modified="2024-05-29" version="1" fragment="single">RGTAQTLLNWILAVNAEILSSTLFLFRADFLCPVWRTRIRKVWISYLKVHKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNF5</accession>
    <name>A0AAE0MNF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_435246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677991.1">
        <property type="nucleotide sequence ID" value="XM_062825186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNF5"/>
    <dbReference type="GeneID" id="87862340"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="92"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="902" mass="100635" checksum="97EBEEDD5A4F4140" modified="2024-05-29" version="1">MLTRARETGGGILARKLFPDKVNYRLIGEWLQLCRSGHVRCDSREADEGDGGVGTGQIPGFQVIDCTTGNIVSFASLSGGTSCGEQSQTPEYVTLSYVWGQGPFEGPVKIKPPPGSGIRQQQRLSLPDSLPLTISDTIQVVQRLGYRYLWIDRYCIPQDDLPAKQIQIENMGRIYSRSVLTIIAAAGEGPEYGLPGVSERRRAEQLTVQVDAAQHEGKGISLVLYERPRAAITNSKWHTRGWTYQEGLLSRRRLVFTDQMVYFQCYEMHGDEVLSLPIPDGPSGGHVSDDVKDKDKFDEIRCLSLDDQESNFGFIFPRRMTDWSNPDTVWDRIKEFCQRELSFDADTLDAVAGIFGMYTAENPSKHQGDGTSFFYGMPIAPFQPERNESNQQRLWTCELRTFWETYENNVPGNNTDPIPKLEVEEVDVKTSLTYKLVESLLWTDSWYHVLKPDKIQQLSQQFRRPVFPSWTWAGWKTCIVERDRLFSKMFDSRTKIHVEYELEAASPASSSPGLTHAHAQKATKWRRLDWERENEEILELARNGAYKIPARLVIRGTVLDMRLKWRGGEENNEELWWRKVGKWTVTWPEFMEGKEIDVPRGLLDDTSEPGGRISKGEEEVQALALILAGRAYSGEANGSLLALMLRPVTRMLNGRSETMYERVHKMDLYVRKEEYKAEWTPLAGLFREMEVRFISTKAGANQGIGYETAKNLVQSSADYHVILGSRDSSKGEAAAQALQQADGVKAKGTASSVSLDVTDEASIAAAAERVAADFGRLDVLVNNAGIISTASPPTAQALRRVLETNVVGALAVTEAFLDLLRKAEHKPPRLVFYSARLKPEGFLVIGADPGLCATNFTGDAASLRNRGAVEPADGGDRVAAVIKGEKDADAGRVIGVYGVSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNH2</accession>
    <name>A0AAE0MNH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_541864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678423.1">
        <property type="nucleotide sequence ID" value="XM_062829190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNH2"/>
    <dbReference type="GeneID" id="87866344"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="249"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="791" mass="90987" checksum="812ED089F9205725" modified="2024-05-29" version="1">MGRPCPEVDEPHSCAFCEEHLALDFSKVDGAISPTRLEQMQKRLLQVGFLGQNESLYDDKYAWFRLELENYHIYDMNLNLFWSEVVDACPLAERIRKRIGQRKENDEHYLLTAKIKRNYHDEQDIVSISYDNVKIEPETRPFQLGWRLQRSHEPLLFSSSGEMGSVLRMEIMADEGSVTAREFPRRAINHHPLEHTLEHARGWLESCLRDHPDSSEVPKYIPKRLLEISRSLDGSSWVTIVDGSTPVAYAALSYKWGGIHEPRLTRSRLKGAAASALQFDLEVLPKTIADAVKVTEAFGINHLWVDALCIIQDDDADKAREVGQMSQIYSQATVTILASRSNSASEGFLHCRHGRECHESAEKSYLSKWDFRLPYRTFCGEQGSIIITEQGLDPYHQEPLDTRAWAFQELLLSPHIISYGTLWTVFDCLRVIPSLPSQRNRVRFSDDGDIMPYDKFGPKCIRRDIREVLHMPYKGSDHNLNTNRWGRDHDQPMDESLWELRRKMEGYQSLWDRPHYHAMYLWQVLLSSYTSRGLTNPQDRLNGFAAVAEVFARYLKDEYVAGFWRSDLLATLIWARKLTFGRHPQKRPTEYCGPTWSWASIVEPVCHPISPGLLRWDRNLLILDCQAKLVDEATKFGAVSSGFLKVTGKIVHGTIAMCPCCAVKASLPEEDDPFGVNVNWPTEFEPEGKVRWEDLGYHYRPDVLEQDFLEGDHSIPVVFLIIGFGLRQVCYCLVLREASGGLYTRLGLLEFMMIESTGKFPNMVCVLMRSVGIKLFLSRHLPSYRRIHRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNN7</accession>
    <name>A0AAE0MNN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_283939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678261.1">
        <property type="nucleotide sequence ID" value="XM_062822917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNN7"/>
    <dbReference type="GeneID" id="87860071"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="358" mass="40825" checksum="124F6B6F2FD571CE" modified="2024-05-29" version="1">MAPNTKGSSSAAGPTKVPISMLLSNEEQTAIGILPASHWQQQFTQEDPSDIFSSRARTASLTESIFQYRHIHGRTYHSDIGNAESWEPNDERHIDAMEIAHHAYTVTMEHRLYRAPLDKNKVQKVLDVGTGTGLWAIDFADEFPGADVVGTDITPIQPSWVPANVKFELDDCNQEWTWPDNTFDFIHARMLIGVIEDWYEFHRQAFRTCKPGGYIETFAACSTFECDDGTVKEDSAMSQWSKVFNEGGRRFGRSFEVYDHDLQRKGMAAAGFVDIEYKDYIIPIGVWHPEKETAESGLWWKLAIEADLEGYLNYTFIVLLGWTPEETKSYGDQIKKEWNNPNIHGYVRARSAWGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP78</accession>
    <name>A0AAE0MP78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_580926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678846.1">
        <property type="nucleotide sequence ID" value="XM_062830804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP78"/>
    <dbReference type="GeneID" id="87867958"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="595" mass="68206" checksum="DBA148C813595DC7" modified="2024-05-29" version="1">MGPPPRASQWRGCAEHGTDPYRLYVATAVHKDCFVIAKQSCPLAPRLACERIWELAVARSLWLYALSLRSLYLISLQAVNQVASIINIPQLINFSSELVERIRSYLPGNALFWRAVAALTVASSLPDLPISAEQRVEIRHILHWERGEEIATIGPRGQHDVLRLTFDVDGIREIERFCQQPQCEDWQMNNRRFAYALLDTKRDEFSRRFVYCRNGLLRLLLDADDKYYDHDHDMDIPFLPRVWDTPTPPDLTMSNNLFHHELFEVFSTGHYVSLDSISGLIFVYRGKELVAIHPHRGDDVEMDCPKTSASGSSRVQEACFFLPVTKEDTILGIGVGDYQNAFVVVVKKRLSGETVIGLPCLEPPEDNFNWEGPDEDEEDFFDKRDFMWGQRDPVALVYGFLGKRKYLDLLGGYRGTRLAKPKWEGWRGTIPHLWPSGLFSLDDEEDLRFYTRAPLRGVVAAQMFFYPSHPKRPKQRVCSGIIFHYDNGGSRVVGEIRLEDRAKLAGDMIINPKLICLECEILPGFDTPNIHFVTESEIESEAHPDEAGWSFDDCPQFPGIAMTCHPMRGIINWWFTARQRNSIEIHEWADEVSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPF9</accession>
    <name>A0AAE0MPF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_472860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679517.1">
        <property type="nucleotide sequence ID" value="XM_062827167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPF9"/>
    <dbReference type="SMR" id="A0AAE0MPF9"/>
    <dbReference type="GeneID" id="87864321"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="57"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3340575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="194" mass="23056" checksum="BEE96E591581ECE1" modified="2024-05-29" version="1">MLNTRQRSTVERLDRPSAYFFNKNRRNRRHDRDHRDGENEDSNMHPEAFDDPLKDATTLYVGNLSFYTTEEQVYELFSKCGEIKRLVMGLDRLQKTPCGFCFVEYYTHQDALDCMKYIGGTKLDERIIRTDLDPGFEEGRQYGRGKSGGQVRDEYREDYDEGRGGLGRQIQAERMREHDHKRYDDNDEQYGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPH9</accession>
    <name>A0AAE0MPH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zeta toxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_263553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679503.1">
        <property type="nucleotide sequence ID" value="XM_062822654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPH9"/>
    <dbReference type="GeneID" id="87859808"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta toxin" evidence="5">
        <location>
            <begin position="53"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3340561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="350" mass="38723" checksum="DC446633A4A6C746" modified="2024-05-29" version="1">MANTFPPSWTLTPSARLEIFTTQILPAEQPYIPVSPPSPPSPSTSTSTTEATTTTTTTTTTRRRPLAILIVGQTGAGKTRLAPALLSAMTASHPSHRPPAHFIADTYKTYHPHYLACLSQFPPAQASVLAGLDARLWLQMACEHAVQHRIDVLVESACRHPDDFCRLAEIFHRGGYVAKVAVLAVPEGLSRLGCLVRYWKRLPEAGSRGLPVRLTPRRVHDESYEGLREAARWVDEGGIVDGCVVVRRGEGVAYWNERVELDGERKWAREPGALKALEIERARKLSEEERRILEEDLEVLRKLGDPKVDQELEAIQTLVDGIGVGFTGTFPELEPLDADEFVRGRSALGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPT3</accession>
    <name>A0AAE0MPT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_276461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679877.1">
        <property type="nucleotide sequence ID" value="XM_062822815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPT3"/>
    <dbReference type="GeneID" id="87859969"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="234" mass="26066" checksum="0F083A9472C47287" modified="2024-05-29" version="1">MARPLRGIVRPAPRKGTSKGTSQWKASHATWQPLSLIAPIIPERLLLLVSHEPDFPVQKVNFSKGPTQNPWGITDFHRASIKANWTIKKATGTCLQSISANMSTFYLPVFPASWALLSHISRRWAKVHSCTEFIATPRVRGTSGIGTLTVQTPMCKPRPVFYQKQKEKGSLRIFIGSPCSFPTQLIINKKVDPGQSKVLLIISGAAGWQRQQQQQQQHSKRRRLSLSAKVGACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPX7</accession>
    <name>A0AAE0MPX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_252594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679174.1">
        <property type="nucleotide sequence ID" value="XM_062822496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPX7"/>
    <dbReference type="GeneID" id="87859650"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="398" mass="42098" checksum="50D4853A7F3BB818" modified="2024-05-29" version="1">METINKVASAAATTASNVAVEASNLAAQASKAAVNAVYGTNQSHEEPISGKTGDVSKGEPYDAGNMEPGESTGVAVGERMVTDRTVRPTSPKITQDAAGPVKEDGTEPKPANQVKVPEAEKDHSPPTVNSRIDNHYNIPEHSTVNPKTTDIKALDNNTSSHETTAIKPLDSNTSFPTTTTHTATAIEPLNDTFSSHRNIPAEQSTTFQDQSSSKHDVPKVNPAATQDSSRQTGDSTQAQNDIRSPNDPSTHPTHVNARVNVDDRDGGLDANKNPNKELGSGPKPLVEVAKQHDGDAGKVENGGVKEPQSGAPKEEQTKPESHHIHHATGFVADGGDFDAAAPGAGSEADRLLESTGIHRDNANGPLTGNTEALDQHDQHGHKEKTSLKQKIKDKLHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ43</accession>
    <name>A0AAE0MQ43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_273273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679791.1">
        <property type="nucleotide sequence ID" value="XM_062822772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ43"/>
    <dbReference type="GeneID" id="87859926"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="8">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="157" mass="17294" checksum="F2E848509695268C" modified="2024-05-29" version="1">MGKVTKFGDDGEEVTMKETPTSHQPEAQDDVSMADAGEEGEEGEEEYEGEEEGTKVRLLPGSTPTAASFEFLEENHTLGNALRYVIMKNPDVEFCAYAIPHPSEAKMNVRIQTYEGTNAVDALRKGLRDIQDLCDVVSDKFLEARKDFTEKKAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQA9</accession>
    <name>A0AAE0MQA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_431676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679579.1">
        <property type="nucleotide sequence ID" value="XM_062824960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQA9"/>
    <dbReference type="GeneID" id="87862114"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="68" mass="8007" checksum="FEBA1E6481772684" modified="2024-05-29" version="1">MTGCWQRRANVKPLPAVKRLEKAVDLSSWVPMRLTNNQTDYLSLARPRTTRPFWNRIQTQGPELRIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQP6</accession>
    <name>A0AAE0MQP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_429731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680808.1">
        <property type="nucleotide sequence ID" value="XM_062824840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQP6"/>
    <dbReference type="GeneID" id="87861994"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="5">
        <location>
            <begin position="152"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3343015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="473" mass="52691" checksum="F9B81DA1D366A126" modified="2024-05-29" version="1">MAATVATSLVTDNETPPLTPDPTPAVGVTDAATISPAAEPPAVAITPSDPWPRPYYIEDGLRRVVPYHYTYNTWCKERWRGRKLMEIFEVEFRDRPAEYYRNAVETGLVVVNGKAVGPEYVLKNGDLISHTTHRHEPPITAEPIRVIHEDNDLIVINKPSGVPVHPAGRYNYNSVVEIIKSERGPDFLPRPCNRLDRLTSGIMFLAKNQRAAERLVAQISQRSVRKEYIARVVGRFPDGEVVCDQPILQISPKLTLNRVRANGKAARTVFKRLAYYPPVDPPAKGQTEQPAMPDAEQTAQRRGEGEGYSIVRCLPVTGRTHQIRVHLQFLGHPIQNDPIYANQKVWGFDLGRNDADAARNSDEDVISRLSRMGKEDVADAVAYYDEMVDNYHKKKAEKMSGQVCDVCQTPLYTDPGEQELSLWLHSLRYEDADGAWSYVSPLPAWALPPSGMTGPTQVGGMEDLVSAVEASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR10</accession>
    <name>A0AAE0MR10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_244764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681062.1">
        <property type="nucleotide sequence ID" value="XM_062822371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR10"/>
    <dbReference type="GeneID" id="87859525"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3343269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="476" mass="52931" checksum="C2EECF89BB84137F" modified="2024-05-29" version="1">MTDQQQQQQQQQQQQQPHPFKRVLITGAGPSGLLLALLLSKHRPNPIPVTILEASHELDSQPRAAHYGTPCIPEFIRAGIVEKIRERGLVLSTMTWRKPGSFEEVGGFDARGLRDVILEGLEGVPVGGWGLGTGTEGEEGAKEKKQDMRTHCLVLQDLLKLMLEECVERGVEVLWRHKVVGVGHTGEDSKGEDGKEGGKKGAWVEVEVTTGEDGEVKERKKVGGEGCIVVGADGANSAVRKGLFGDEFPGFTWDRTIIATNTYYDFDKFGWSDANFIIDPENFFMAARIAPSTPSHPALYRVTYAEVPNLTRAQYLSRQPFKFQSMLPGSPTPDQYQLLTLSPYRMHQRCAPSFRVGRVLLVADAAHLCNPWGGLGITGGFVDVGGLYDCLVGIWDGKADEEEILELYSEKRMEKWKTIINPLSQENFRRVSGQVEVEGDEFLGVLRKVKGDEEGAKEVLLGMMGVRYDFTQHYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRU8</accession>
    <name>A0AAE0MRU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_463858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681199.1">
        <property type="nucleotide sequence ID" value="XM_062826728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRU8"/>
    <dbReference type="GeneID" id="87863882"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="346"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3344586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="541" mass="59826" checksum="B9E195C627E3BFEB" modified="2024-05-29" version="1">MRPSRLAMRPYTCLQCLTRTRPVFPRPTQTPRIASLHNSSRFLQQQSSDSPAASRPSIAPKPVVDIKHIRQNPDLYAHNCIERNYHQQATYPQRINDLHAQWQAKQREARSLRERSNILRRQLTDPGSIRDENADAIAAGTQLLTRDELIAEARNLKSLLSTIEAEETRILSEIESLALSIPNLTSEESPRGPEPKLLSLINEHPEPVPSASDRVWRSHVHIGNELGLLDFASAGTTSGWGWYFLLDEAAQLEQALIAYALDLAVRSGWRQVSPPSIVYSHIASACGFQPRDQNGETQIYTLAQSADDAARGKPELSMAGTSEIPLAGMHASKMLLCPGDISEFSPLKYVAVSRCYRAEAGSRGLETKGLYRVHEFTKVELFGWTYPSLDSASDVFNEIVDLQTDLLSSLGLHCRVLEMPTHDLGASAARKIDIEAFFPSRRERNEGWGEVTSASICTDYQARRLATRLKGEDGKMIEGGYPFTVNGTAMAVPRVVAALLENGWDEETGTVVIPEVLRGWMGGKERVGPKPPTKKGLGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSY3</accession>
    <name>A0AAE0MSY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_422862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683238.1">
        <property type="nucleotide sequence ID" value="XM_062824422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSY3"/>
    <dbReference type="GeneID" id="87861576"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="300" mass="33755" checksum="922B866ECF09AF64" modified="2024-05-29" version="1">MCRINIIHFSPHHHDFHSEAPPNSLRLTTICNNCNLFNSKSSSIAFAKLNLLPRRPTEDEFMTQRQPPHQFVLCPTHVNSCCCVAYKQTTACLLQKFHSAGWQWQDVAAATAATTAAAAAAADVDGDVNGDFQSFSQARTSVLGTADEIHKQKVVMDKHLLEASELLEQLFLDLADARATIHARQPAQRRASFFREFEIPLQRAVELCQKIREADERICEDFKVFLQRRKGMSNLLMAIDKKETINSGFYPISKARQDLTELSASNIREVCEGSLRRGRELSAELVRLLDAVSNFVQPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MU09_9PEZI</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_176524</name>
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    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683539.1">
        <property type="nucleotide sequence ID" value="XM_062821446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU09"/>
    <dbReference type="GeneID" id="87858600"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="355"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="512"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3348457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="533" mass="59692" checksum="649CDB608ECA8BB1" modified="2024-05-29" version="1">MDNLSSPSSGLSALRSQLSSDLEDQLDIESALRSSQKKIKKLRKQLEAVSSGVEQMRENYTTLKGALLALDRKVKVESEKSRLLIGAGLRRERRRKEREVVEGGDEGEGEKEEEEEEDGGDGGDDGGDDGGNDGGGDEEGEGDEEEGEEEDKKRKRKDSSESNPSTESASSSISVEDTTLRAVERIMPLQSEEGNQEDTIENTEGGSSMSRQGNKKIHKAKREAKRVRIISPESESEEDDKKTETESKCEEELPDDGGEMDFDQELQVKVILLEQRLKRYEQGMNKRVQKLEEDMKEGLEWLQSDMNEKFQREENDRNEVVEEVEENMNKRVVKLENRMSWNEWIGETIAYGGGDTEDEEQEEDGDEEDSDEEDGEEEDGDGEEQVDDDENEEEEEEDDEDNEENDNGDDDDDDGNLPSPTAHHPTTGGKQPMKTIPEGYGAGDTPFDEWYPRYSSQATLLNSDQAEGGGGEEDEPSPEQPGEEEDDREMGNIQSEGVDEVKEEEAVDGEEVEKGVKENRTKEDIAQNEATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU53</accession>
    <name>A0AAE0MU53_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_547669</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062829533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU53"/>
    <dbReference type="GeneID" id="87866687"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="119"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="218" mass="24021" checksum="C4F6E245EEED5988" modified="2024-05-29" version="1">MSDDGWDDDYVDDGSYDDGPYDDYAGDGGYDDGPCEDYTGDRGDCDEQDVGTTGYAEVEEVNDDNYRNAEGDNGGGDDEDVGTAGYAEEVDAETTGYAEVEEVGNDNCSNAEGRVQVLPHHHHRHHPYPHNILNNDNDHDDRTSSDLVQNADRDQDQAEGNDEDGPSMSNYEYVKPWGGMHGFMRSYGIAREPGGYEEAGELRDAMMEAAHKNRNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUR3</accession>
    <name>A0AAE0MUR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_539007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683570.1">
        <property type="nucleotide sequence ID" value="XM_062829105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUR3"/>
    <dbReference type="GeneID" id="87866259"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="115" mass="12449" checksum="2B88A1FC4DE1FF08" modified="2024-05-29" version="1">MNISSVPDYLMPHFISPDHRSLIYVPQICLYGGHIAPLLLILCLSFRSSRLPLLIPPATCCSSTGRESLVEGIIDAYVSFTTLLINDIQFKSSHRAAAEPAVPAVPGIFKLGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUX7</accession>
    <name>A0AAE0MUX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Clock-controlled gene-15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_421640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685277.1">
        <property type="nucleotide sequence ID" value="XM_062824353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUX7"/>
    <dbReference type="GeneID" id="87861507"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042159637" description="Clock-controlled gene-15" evidence="7">
        <location>
            <begin position="23"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3351982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="43360" checksum="A8B43916E7D181E3" modified="2024-05-29" version="1">MLVKYLAPAVVAIGAASAQTAAVPTATCTVSGGTTTVNSQADATGLANCRTVKGSVVVTKDVAGDFELSGPEIITGDLRIENNPNINSVGSDTLQMIGGEFSLTQLTQLNSINMLKLTSVSKLTWQSIGNAADMGMTQLNKVDEITISDSHLRNIDAINVTSIKSMNLDNNQFITKYEPAIKSISGDLTIQANGLDMEVSFPNLIWAMNMAVADVSKISFPSLQVVNGSARFDNNKFDSFSFPNLTQTKTGDISFVGNENMKNLTFPKLTQIGGGLLIANNTALTDNGDFPVLDTVVGAIKLRGNFTEVKFPKLQSVRGAFDLSSTNDVTNDCKTLAKMAPTTQGGNGEIEGTFDCQSNNKEANQDTSGKTGSGEGVTGGSGSDKTSGTKNSGAAGLSVNAGLFLAAAGVLAQLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWH4</accession>
    <name>A0AAE0MWH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_547096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685415.1">
        <property type="nucleotide sequence ID" value="XM_062829488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWH4"/>
    <dbReference type="GeneID" id="87866642"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042079248" evidence="1">
        <location>
            <begin position="36"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="348" mass="39030" checksum="3B515993EEFC0A6B" modified="2024-05-29" version="1">MHQRSFKPTTKHRATSTKTALLGLLMAAPGVWVDAAPGVSLDAVVANKLEAKSHHGVGDVDKPVIIAAKKPEDDDPWLMPANKFYDNYLDNYWANRNQSSVHGRSSLVGMAHRKRTVPKYDSALYCGIFATGYREDISSLLWDFHTQKNIIHYIVGWRECRRVACKNTSGIYICNDTTQTVRVTGERIYSLGKIPSDNCCHQGPPENPTKKAGHGMSGQKFTGTGFNVIVAYANCNKGEMEYRPQMGPEDNPWGPNLQCFTEFYGLSPSPTNGDVVTKRKRDGVVEEREWELVDDGTGVMDLKEKEVKGVVEEREVEENEVGGDVDVLKLEEWEMSKRDERAVKRFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWJ4</accession>
    <name>A0AAE0MWJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_33515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686421.1">
        <property type="nucleotide sequence ID" value="XM_062823555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWJ4"/>
    <dbReference type="GeneID" id="87860709"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="319" mass="33128" checksum="3D15D0E7BB43A401" modified="2024-05-29" version="1">MSTRQPSRVVFVGNIPYGLTEEQITEIFSGAGRVLNFRLVYDRETGRPKGFGFAEFPDYDSAASAVRNLNDHEIMGRKLRVDFSNETVSDEDGGRDRDGGPNQNASGSYAQPPNGGGYNAAPPASAAPPALGPLPQGKDLPPDVTCTDAISRTLNTLPPAQLLDILQQMKTLATNDPARATELLNQAPQLSYAIFQALLVMGLVSPDAINSVLDNPAAAAAPPMGASVVPNPMGGAPYGAYPGATATPPVAPGPAGGYAAPPVAAAPAPAPAAAAPGQDPEALMRAVMELPQEMIDQLPDAERQQILALRAQFSAQGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX15</accession>
    <name>A0AAE0MX15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_415640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685970.1">
        <property type="nucleotide sequence ID" value="XM_062823997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX15"/>
    <dbReference type="GeneID" id="87861151"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="458" mass="48623" checksum="401313F287D655F2" modified="2024-05-29" version="1">MSSTTTTTTNNTGTVILGAGIIGVSTAYYLSLSSPQSSSSSEIHLIDPSPTLFWSASGFAGGFLARNWFAPEVSSLGALSFAEHARLASAHDGRRNWSYAPSTSLGYSAVAADKGVKKRGDDWLRSGTSRAEAAPGDQKQKVPVLSVEDLNQKTPAWLRRREGDDVEVIGGEGDAAQLEPERLCRFLLEEAEGRGVKVSKGTEAVEVLRDGEGVVSGVVVRDVKTGEEREVQCSRIIITAGCWSGQVWEKLFGATSETVKRLPVTSLAGYSLVVKSPRWAGAVDGEGCHAVYTSHAFCPEIFSRVGGQIYFAGLNSAAMPLPNVAEGSKVPTEPMQLVKQAARELLGSGKDGEDDLEVVREGLCFRPVTPWGLPIVARVPDEHLGGGIRTSPGAEGGVFLATGHGPWGISMSLGTGIVMSELESRSCRCCSTVLQAVMNSFEDSRRAAGFSRRLLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZY5</accession>
    <name>A0AAE0IZY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_437273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676584.1">
        <property type="nucleotide sequence ID" value="XM_062825297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZY5"/>
    <dbReference type="GeneID" id="87862451"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="236" mass="25625" checksum="7E101D2F39E65A19" modified="2024-05-29" version="1">MAPLPGPPPQGGFTFTISPSATHLNHPITHFLSTPLKGSIKPQGLAGGALVFSNSAPDAVDRILLLQRAPHDSMPLRWEIPGGACDPEDESFLHGVAREMWEEAGLVPKRMVCQVGGEEKPQVFLTRSGKVVLKVSVEVEVDEGSGVGDEEGEGDGKVDGKWKGLPKVVIDPNEHVRFVWATEEECRAGVMVIEGERGEKEELKLVFTTKEQRETILEGFEGRGKRALEGKDVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0T3</accession>
    <name>A0AAE0J0T3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_83477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676616.1">
        <property type="nucleotide sequence ID" value="XM_062831470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0T3"/>
    <dbReference type="GeneID" id="87868624"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041938193" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3334450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="502" mass="54427" checksum="6F34446CFBF58926" modified="2024-05-29" version="1">MWLPLILLTATAAPILANPLTSPLNKRAAIDDCLKSAGVPADAQGSSDWRADVNPFNQRLPYTPVAIAVPTTVEHIRGAVSCAAKLGIKVTPKSGGHSYASFGLGGENGHLVVELDRMSKVTLDKTTNIADVQAGARLGHVATELYKQGKRGFSHGTCPGVGVGGHSLHGGFGFSSHTYGLAVDWIAAATVVLANSTVVTASPTENPDLFWALRGAGSNFGIVASFKFNTFAAPSQVTAFQINLPWNSASSIASGWGKLQDWLAAGNMPKEMNMRVFGSPSQTQLQGLYHGSSSALRTAVQPLLSTLGASLSNAQQYDWLGAFTYYTYGGTVDVTHPYNTVETFYSKSLVTTALPSAALNSVANYWINTAKRVSRDWFIIIDMHGGPKSAITSSTTNSANYTSSYAYRAPEYLFLYELYDRVNYGSYPSNGFSFLDGWVKSFTDNMKQEQWGMYINYADPTMKRAEAVGNYYRGSLSRLQQMKAQYDPNEVFYYPQSVEPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0W8</accession>
    <name>A0AAE0J0W8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_74277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676663.1">
        <property type="nucleotide sequence ID" value="XM_062831357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0W8"/>
    <dbReference type="GeneID" id="87868511"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="248" mass="26259" checksum="F263C9F1B2D710C3" modified="2024-05-29" version="1">MEMPSVLETRESNLLPHIIQFLSRSIRTATASLSLTKRNANQTPAFDFAPTTTTPRDHQLIPRDSAPLSSTALLGAILGSIGGVIFLVICCFFYIRFRAWGNASMAASSRQRRWRRVYYYHDSSSTSSSGSSSTSHSSGSTSTRTIPRDVEIGEAWPGVGGAGAAQRGYGYGQGKHYGQDSVYGQGGVYGQSQAQRGYGVGFEGGAKGGSVGVGNVATGYGPGVAQAPRVPPVATTKWSPHVFKQGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J156</accession>
    <name>A0AAE0J156_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_331570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823514.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87860668"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000273">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000045">
        <property type="entry name" value="Actin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035718">
        <property type="entry name" value="Abp1_fungi_SH3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
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    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="642"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="741"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3334770.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J190</accession>
    <name>A0AAE0J190_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_78010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676841.1">
        <property type="nucleotide sequence ID" value="XM_062831405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J190"/>
    <dbReference type="GeneID" id="87868559"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="218" mass="23987" checksum="D64195D59271F5A7" modified="2024-05-29" version="1">MERHARGWPFLCSAVTYEAHTQSTTTSSPRSSFDTDKSPCDHTSPLLRNAAWSLVMRLRNSHQGPSWTRLGDSVVAHIISCPLGAKVSLAGVFVPSLSSCTTSPYTSPKYQQKSPKSAKMEPSKIALGIFCFPKRDMLSGHRALRLVPLLLVLKRERHRRQTPTYNFPKALFLLAPSATALGPSSDWHNVALADAGLADAHSSDPFDTVVELTFWNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7I8</accession>
    <name>A0AAE0J7I8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_310205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677461.1">
        <property type="nucleotide sequence ID" value="XM_062823284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7I8"/>
    <dbReference type="GeneID" id="87860438"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="126" mass="13082" checksum="74E5804D9F1D77CC" modified="2024-05-29" version="1">MPRLHKAHGSAPYIYITSPDSSNSSISASASDFTPGSNSPTSSDSSSSSSSSAAAAAWRSNASELRDVTRDFSAARATSTDAKTKSYTEKEVARFEAMARNAELMASMAMAASAAKRRDGVSSKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7X3</accession>
    <name>A0AAE0J7X3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_325530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677980.1">
        <property type="nucleotide sequence ID" value="XM_062823462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7X3"/>
    <dbReference type="GeneID" id="87860616"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042082445" evidence="8">
        <location>
            <begin position="23"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="589"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="795" mass="86102" checksum="F61AEBCF3403C5A6" modified="2024-05-29" version="1">MLLDRRLATVVSGLLAITTVSAACTSDLIIDDFTKWVEGTNNLNYPNGDDASMTSIAAAAGKVQFIPKDGGSYFYESFSCQQAVTNGYGGIQFTLEGPAGGSVALELQTSASCNASDTANYTSSYNVISSLTGSQQTIDLPLLGFDNNPNYDAIVGLVWSEFSKTNSIWSIGNIKLTCGAVAAPTTTTAPTTTPSSTTRSVVTSTTRSVITTATRSTSASPTATACSNLLIDDWESQSRLTFLGYNAMNQASSDDGTMSSIVVSNHRVLLTPKDQQSYFYSQFGCLNTNNKYGGISFRIRAARGTTFAVQMSYFATCGSSTGRKTISMTSTQLKWTFDGTERLYWFPFSVFTGLDTTKLDMIYFSSFNAAVILGPMSFYCGSTASEYILPTLPPPSNTGASPTVPAPSSNAKPFVIDTFSNQDTNSLGQWHGGDDGMTVTFGKNSITIRTNDSDLGWNTQLAAKCFDLTPYSTAYLHVAYRGSNKFSIALQQHNAQCDESIKPYPETWDSLEAARYSFGGSDIYIPLSHFAINLTRTIGFNLRGFFSPSESTTISALEIVSSVPSSSSGVSIPHKLPSGKLVFACTRPNSFAFAIDDGDPKLAARVASIVSAASIPVTFFTVGLPLLDPSTNLSKIYRDMAARGHQIALHSYTHPKMEGLPTIADIDWEYTNDIGAVRQTFPSSKVSPYFRPPFGTEGARMRQRLVENLGDENAHIVGWSIDVEDWLWAESDTPEKQLEAFKRDLKAGGNLVVMHYLYESTVGYLEEFIKLAKGTGKRLMRVDQCMEDPNAPPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J852</accession>
    <name>A0AAE0J852_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_582061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677761.1">
        <property type="nucleotide sequence ID" value="XM_062830839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J852"/>
    <dbReference type="GeneID" id="87867993"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="276" mass="32400" checksum="8AE5D3B5544F5089" modified="2024-05-29" version="1">MSDEGVICGLDTGAYRPFPLLLLPVEIQLQIYRFAWMTGPIEEHRTRVRGNGPEYILRCVKNQLIQREMSKKVKEELSTVCTMRSVCRHMRDVVYEEYFSRTQAVLQSNIILLRPSQSAISNDVRTVIHDSTFISEHVRHACVVINDMDFTSHNGPGDDTLRWLTSLRKLTTLEVVFEQWQDLASRNSIFWRHPGLESAKLGIQSLPRLEKLVFRLKWGHIYPQEEAISWEEFPWFQELRQVFEHAPVSENTEQRCFKFKNHIGVTYPDWPCSYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J867</accession>
    <name>A0AAE0J867_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_435221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677788.1">
        <property type="nucleotide sequence ID" value="XM_062825183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J867"/>
    <dbReference type="GeneID" id="87862337"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3338337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="847" mass="94013" checksum="2D1D5828142B5FDE" modified="2024-05-29" version="1">MASELTPPDQRHDYLHQHPQPPLPPSSSSSEQRHPVGVHSLQAVPEPSVMKLTRGHSCVLCQQRKVRCDKQKPCANCVKAGVECRVVPPQPPRRRKKKPHERDLIDRLKKYESLLSQHGVNFEPIAHDLKTSDSIDDVADLEQDLSGLKTSPSSAADHVSPSDQGYDKQKWFPYNKEFRAMDEELADSSDEDCEGPTLHHAYDTMFDNNDGFPFVVGGSPTSVTNSHPSSFQIFQLWQTYITNVNPLLKLSHTSSLQKQIISAGAKPANIPKPLEVLMFAIYFAAVTSMTAEEVQTEFGEDRTILLAKYHGATQQALVNAGFMRSNEIMTLQAFLLYLLCVRQYVDPRSMFCLMGIAVRIATRIGIHKDGQQFRLPPFEVEQRRRLWWQIVILDKRIAEITGSAITALSSCGGDCRFPLNINDSDLNLHGKDFPTQYPGPTEMLFTLTRIELTVAAEPNGLRAVVTTPGGTRVTQPRVHFSPSPASPDVVTHVANTNLPRDLESFCTYMENAYLKYCDPKVPLHFFTLLMTRQALCKLRVIDFLCREATQGIMDHNERDALFEQAVLMVEYDNMLQGNELLKGFKWYTMLNFPLPAYIFLVQDLRTRTTGAPCERAWTLMIENLERRGLTSNLRTPMHIALGGFFVKAWDAHEAAQNQLGRHLQTPKIVTLMRNTAAKFKRPNSPPQVGSGPVGVVGGGMSMSSDPRQSVPNSATPPGMMPVASMPPDMAGMTGPHGLPGVSMQTGMYTTPKQMQQTSQTDTSPQMGSANMMMNDSMMFGSPNGGFDTGMGQMFGAGPSAPTPAGSMDLDISQMDWNYLVQLSSFGGFNPNYSAQMQYPHQPGPGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J898</accession>
    <name>A0AAE0J898_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_319852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677801.1">
        <property type="nucleotide sequence ID" value="XM_062823396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860550"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000494">
        <property type="entry name" value="Sister chromatid cohesion protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="3">
        <location>
            <begin position="1505"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1716"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1852"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1720"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1731"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1853"/>
            <end position="1863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1949" mass="215671" checksum="2DEA9B5F6F4E7A3B" modified="2024-05-29" version="1">MDPNAQDYHGSQGAPASSSPQQAGGFMRPFALYEALPYTPFTSIVPFDPSILPTPSIGAASPAPSVLDLLSTQEFDGLNQEVRNTGPSKRVQQTLSQVQHLIERANITEFKFKTGPKAPTSGSSSAVAPIASLASTLSPFSKMFYEQTSIPFRYPTPDTPGMTSANGQQPKVERTTPVPIKQESPVPPPKVEHRAERQTPTNAPKNRQAHSQNRARFEIVLPTRAELERAQAALQASSSQGIASSEPPVSTRPPISQPPPQFAPIQPVLIQPAPPQPAPQQPTLSAPPELAPPVAPKRPSEEVAALPSPALVVRGSPTKSTSQAPSNSQQPAVAIAIELPHAPIFNKSEYMAIPDEPDEPVNLSERKRKREDLDEELYGESLGFQQRSNAALHELKVFLQQVFEAENHAVHNRTSNEWVLLTVDGESTLSPVCQTKAQTLLAKVIQLNCFHKVPLQDLLRLLRFCENALKQADSLEIKVEESWVPADVDSWIQQLPALETALKAARTALRMMCGGREDKQLYSEDTIDQSLNLFKRVMDGIVIPVAELRSSDNTAELFKLLSSHKKRIASLFNDSQKLFSQMSVLLAKIDTSDTVTNTLEFTASQLIFLETAHTERESVLDTQKFDGFRLVAMDMLSQIFHLNPAQRQGIFDEILTSLEKLPLGKRARTFKLVDGNSIQPVSALIMRLVQTSAGQVDETKTHGGKALRSDGDEEEDELAGAVTGGKQLSFVIRDEDHGAIQHSTAIQELTALATPLMDTAKRNASYVVNFIVNRALTSTKSGDTPYRNLLDLFVEDFTTCMDNPDWPAAELLLRLLNFMMVKLVEGDKTSVTAKNMALELMGTMGAAISKLRSHVRKTANALDARDADELGLFLSDLAASALELRSRSETMVAWVGPYRATLEWLESRFTEDPHLASAISFIISDWGTKVCAGYDSCDDDDRERDQEFGRLAYRLRQMIQDRRWLSNEYSFKKVSPNQAKLSYSITLLRSQLCESFSAILNILLGSMASDQPTVRSKSLKSINQVLETDPSILDGDSVVVQLILRCSNDSSTQVRDSALGLIGKCISMRPELETKMIGTVVDRFIDAGPGVRKRAMKLAKDIYLRNKSKAIRSAIANGLLHRVQDPEESVRDLARQVIEEIWFIPFQEGENSASSQISLSDHVALMVQTVKQGNVTNVLDKVLQTLLAPDFKSAAVSLEVCRKLVASMFELVDNPESGDSSVPSGRDALTVLQIFAKADPSLFTFEQLRLLKPHIDSMNSSEDLVVSRAVVVIYKLVLPEVSSVHNEFLTDVRNKLLPAVPKVTRVLLDDIVACLWIISERLDNSDNLARLVCSSLVAMNHMRVSNPNKPLEGMPRKQFERYSLIVGMIGKHCNLDSHFQLFKQSKIGPRMTGSAISKLMVDIVVPFASPIQPLDVRKAALDSVGLVCQSSPRNYVAANVYTTFQQVFDDQNPVLESMVLRSFKEFLFTEEKRSEQAPETAAGDGKGKKKRELTVIGGTNHDDVASATTHRFLKEIIRIATATQDEHAFLAVEVLASINRQGLVHPKETGVTFITLETSSNPRISELAFLEHKSLHGKHETVVEREYVKAIQSAFAYQRDIVKDPRGATVNPFTPKLHLMMEVLKISKSKNRQKFLEKLCTQVDFDVSKLELTGEEIPPHVQYARFIIENMAFFEYMTVGELQSTVYTMEKLVTSTGSTIAQIIESEVFQVRMDAIDGPAPEPEPTPALAPTPGEQPHEQPMAPVQPVQPALPDIDIQRLRQLTAGSMILLALWEVRTYLRRLYNMGTNRREQKAKIQGKDLSRPPVKIQGVAGDKVWEEIGTIMTGLISRERMMQTCKAFVELMNVDKEFLVQDEDEDEDMMDPLTPPSGGEEDDYDEAGPAAGPGRGRKRKASATGPNGSPAPKRRGRPPRSNSKGPQGPPKKRGRPRKNPLPEASQQHDDMEADWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8B0</accession>
    <name>A0AAE0J8B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_445149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678233.1">
        <property type="nucleotide sequence ID" value="XM_062825721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8B0"/>
    <dbReference type="GeneID" id="87862875"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="343" mass="40622" checksum="6AEA32DFA5F8C0C3" modified="2024-05-29" version="1">MSSKSGWPRLLEADRPPPIYAFNNLKIFIKGNISDSIIVVLNVEHINFEKADYQTLVEAIEAQHIITTEFKDITEETCPNPDHLPEDPRWEFNHIARPYHGQFTKSVFKCRADAMEDLYHYMRSLTTKDLTEQERKEGSQREIKVLFWDSRLEERLFKQTRLDLAELGGNIELWDLQIWQPFDHRFRQIRPFFPPESWELRRPHRTKAKTVFHSLGIAGIYLHNAANDNVAEVLTLLSFITMTEQEWDTWHTRKEDLPPKAHASWDQMQATFSHNYAQRPTRSRFSEEDLAWAKSDARIARQMERIRRLEEAGETDIIWDDEAVEVDIKTSEWDIGDSWKFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8M2</accession>
    <name>A0AAE0J8M2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NMDA receptor-regulated protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_434068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678384.1">
        <property type="nucleotide sequence ID" value="XM_062825106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8M2"/>
    <dbReference type="GeneID" id="87862260"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000002">
        <property type="entry name" value="N-terminal acetyltransferase catalytic subunit (NAT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="600"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3339024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="734" mass="83661" checksum="E4B8754746A4531A" modified="2024-05-29" version="1">MPQTLSTREANLFRTVIRHYEEKQYKRGLKAAEQILKKNPRHGDTMSMKALIMNSQGKTEEAFALAKEALTIDMKSHICWHVYGILYRQHKNFDEAIKAYKFALKLEPESQQIQRDLAVLQVQIRDYQGYVQSRFAMLKAKPHLRQNWTALAIAYQLEGSLEQAENILTTYEKSMTNVPLKTDQEHSEALLYKNTIIAERGDIQRALEHLDSDCKNCLDRLAVMEMRARYLGQLNRKEEAAKAWRALLDRNPEHPEYYEGLIGALEIDEKDEAALKAIYDEYAAKYPRSDAAKRLPLNFLTGDSFKAAAKSYLTNMLDRGVPSVFANLKHLYSDVAKKEAVLALAEEYLKEHKGSEQANGDSSKGVGAALYFLAQHYNYHLSRDLAKAMEYVEQAIELDPKNVDFHMTKARIFKHQGDTAKASEAMDHARSLDTKDRYINSKAAKYQLRNNENEKALETMGLFTRAETVGGPLADLTDMQCMWFLTEDGEAWQRRGNTGLALKRFTTINNIFDIWQEDQFDFHSFSLRKGQIRAYVDMIRWEDSIREHPFYFRAALDAVKLYLDMFEKQQAAANGTNGTGEATNGDDAAEKKKAAKKARKEAQKAEREAAEKTAKQDPNKATAKKDEEPKKKDDDPNGLKLAATTDPLGDAMKFLNNILQFSPKNIEGQIAGFDVYMRRKKYLLALRCLNAAQALNPEHPRVKEQFAELQKAVESLDDAQSAKVKEVLKAKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8U7</accession>
    <name>A0AAE0J8U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_591492</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678554.1">
        <property type="nucleotide sequence ID" value="XM_062831099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8U7"/>
    <dbReference type="GeneID" id="87868253"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1210:FF:000003">
        <property type="entry name" value="Exocyst complex component EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="460"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3339194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="684" mass="76585" checksum="8209F1CA3BCD8A30" modified="2024-05-29" version="1">MSEERSKISLRSGGKRKNRPTISSPRQISAPIPQDNGMPQPPQLPPGATMADEPRTMRPRPPPPGGKTSDLVKKRYSTRFGHMPTDFDPSSNPMPALPDFEKYMQAQVGPPPSRGGDAGGLGPAGREPPRVDIRTLRDPNFAPEQYVAEVLGEATEDEIRDYEDALKQLKARAAADLQQNVYQNRTQFIKISKEAEKLKGEMRTLRNLMSELKTNTTALRASSNSADSSGGLGPEFSMSKRDRRSSITDRTALWSAQMQTLYKTVEGSQKFLPNSQGRHVVQNAGPWVELDNATYKSRRSMQIFLLNDHLLIASRKKRKVDAPGADARGPMTKLVADRCWHLLDVEVVDMAGTGDSSNGRNKLADAIMVRGGGQNESFIYRTEKPEDPEKTTLMLNIRKTVEELRRNLQSERDATNKAKETINYFASRDPGLLQKTELLETLSDIKDMLIEVDGKQQNLRWVESQMDELDINIALQQIEPAVARIEMLKNLASGLKNNMIAQDFISFKVDERCARLATLVVRELMNSHNDQKKTKRNVTWLVRLGFEDRAREAYLEARSEVIQKRSRQCIFQGDLHLYIWEISFVYFTVIRNTVICFQSCFPPPMMSACVKWAKEEVDAFNVILARQLSSAEEGGEVWTECVNRAKEHASMLSDVGLDFRNLVGRNVGTSATVSGGAPVGLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8V5</accession>
    <name>A0AAE0J8V5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_541977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678569.1">
        <property type="nucleotide sequence ID" value="XM_062829195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8V5"/>
    <dbReference type="GeneID" id="87866349"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="66"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="370" mass="40554" checksum="7ED611F19FA6A488" modified="2024-05-29" version="1">MIGSHTADCSFHLPEHDEHVPEDLPVSPRLFGICIVSSDSADSTMRHNIRMASNTTTPVITPLAHPEGSNLDFGATVTGVDIENLTDQDFAVLRTALFTHQVLVIKNQSHVTPRAQYELTQRFDPLAAPLYGHGNDSKSGSAAVASKSILHPDLKTIPHQPQVQVIGNGFVPAYEGLTNIQLRHPHHHTFHSTSIPASHDLTHTRFYRWHIDAALYGGVARAPPVVTTLLAVKVPKGRRQTCVYDDGTGDELDVPLGTTAFVSGYKMYDILSDTQKAFARSTRVEYAPHPYVWMSSAKSRSTGLGMVSEGKEMPLGELPEIEEDKIQILPMCWRNPVTGKLALQVHPSAVRRLHLGDGTVVEDLKEGHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J979</accession>
    <name>A0AAE0J979_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Replication protein A, subunit RPA32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_294157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678600.1">
        <property type="nucleotide sequence ID" value="XM_062823053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J979"/>
    <dbReference type="GeneID" id="87860207"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="6">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="161"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="29290" checksum="EBC81424769C4882" modified="2024-05-29" version="1">MAGYGGYGGGDGGGFMSGSQQGGSQAGGSKYADESLRPVTIKQLLDWEEPYSGADPAIDGHPVTQVTIVGQVRSVKPQPTNITYRIDDGTGAIDVKKWVDSEAQGGEDGSGASAIAPDAFVRVWGRLKSLGGKKHVSANFIRQIEDFNEVNYHLLEATYVHLFFTKGAPGGGGVKQEGGGGDNMFVDQGYGAGGGDVAMGGAGPGGGNSAMQARLSTCSRNAQTMCNFINNSPGGTEGVNLHVIAQGTRMSTRDIVNAADELLGQGIIYTTQDDETWAILDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9J9</accession>
    <name>A0AAE0J9J9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_302045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678850.1">
        <property type="nucleotide sequence ID" value="XM_062823150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9J9"/>
    <dbReference type="GeneID" id="87860304"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="329" mass="37294" checksum="9DC68435FA77B4DC" modified="2024-05-29" version="1">MMEGNKPAFFLGPDCVTWARREKVNTASVKLRTANNKQNNSVTTKSQNQQHHLYNPNARLRVSDSGLVIVTMSQPPLYYTSPEVPLEEAPWAWDDEQWIEDSLWSILEGLETPSVSQAHTFMPPSDTCQQTSSTTESTFYPYFDLQGYNSLPENPLTYERPAHSFSSGSPTYTHTPSLGFSPVPSQDSPHSVESLATTPNFTVEEPMDGLLPKDPQAHTESSYEQAQSHPAPTDQPGHSPKLSARRRRRKEKPVKCPIPGCGMGHAYQAELDRHIIAQHKDQAEQYALSVKRFPCPHCPRDFARKDHLTRHRQRRHGLAKQEKRRSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9Y7</accession>
    <name>A0AAE0J9Y7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Got1-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_552107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678733.1">
        <property type="nucleotide sequence ID" value="XM_062829868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9Y7"/>
    <dbReference type="GeneID" id="87867022"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="140" mass="15042" checksum="7519E3AA20DDF69A" modified="2024-05-29" version="1">MPTMWLSDSQKIGVAFCSGGGFFLIGGVLLFFDRAMLAMGNILFLIGLTIIIGPQKTITFFARKQKAKGTAAFFSGLALILMRWPLIGFCVELYGIMILFGDFLGTIAGFARNIPVVGPYIGTAVDRSGVVARQNADLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAN7</accession>
    <name>A0AAE0JAN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_257657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679328.1">
        <property type="nucleotide sequence ID" value="XM_062822573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAN7"/>
    <dbReference type="GeneID" id="87859727"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
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        </location>
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            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAS1</accession>
    <name>A0AAE0JAS1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Emopamil-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_431523</name>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="87862102"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="48"/>
            <end position="65"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17544" checksum="CE7082B275BE45B3" modified="2024-05-29" version="1">MPGGALHYPLWAPYELYGRVDYVYGWKAWNERNGFTAAQGMMNALETGMYLVYAWGVLGLGCGNGNGKGAEGRRGAMVLLVGFAAAVMTLSKTVLYWLNEYYSGFDNIGHNSTFDLVLLWIIPNGAWLVFPSIMIYTLGSEIIDGLAGPSTEVDRSIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB09</accession>
    <name>A0AAE0JB09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_432002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679316.1">
        <property type="nucleotide sequence ID" value="XM_062824973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB09"/>
    <dbReference type="GeneID" id="87862127"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="723"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="665"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="825" mass="91216" checksum="6D440AB248B69900" modified="2024-05-29" version="1">MQQQIGMSYHRAKGTREATTIMGPRPDPSGTSSSTPRPAQSGRKGSKKVRTGCLTCKIRKVKCDEAKPFCVRCTKTGRRCDGYLDAKTMISRRPRRSGGVSQTGANNPRGSLSVFYEWASSDEKRSFHFFQDVTAPCLSGDFDGAFWRVLVLQICESEPVVKHAVLAVSSLHEAMVRGAVAPYVDITDKQSFALFQYNKAISCLLDRMPDADSRPLVPLLTCILFVFVEFMQFKDVESLIHLQQGHQILSQLERKPSLRGNPEFEIIRNHIVPMYTRISLTLMMIGGDPTAIPVPLKTLIDVPTTFETIDQVRYALHDFMEECLRFTKKSKPAKYQQVSPEELRALEEEQDLLMRKLSRFNVAFSLFLSRNQKLLPPGCVDLIEIHTKTIHIWISTALSTNETAFDDHISFFSAIIPRASAFMETLSSPTTRENQTTKAGTMTATGTAASLTDARRFSAMFTFETHVIAPLFFVAIKCRHPEVRRAALDLLRRNPARRENVWRADIMASIADYTIKLEERHLHSPDSDYAPPHQASPPDATGSPFSYPLAPGEMWSSELQDTPFGYNDADSSSGSVGEGTVDLAQLDLSNLPVDPSLLLAEDQHSVHSLSGYSYSAASSYDMDAAAESNGTIYMDVDVNNTPVTVPMTLSAAVAAVTAATSTPTTLSATSPAWTTTTTTTTTTTGTYPTPSIFLEPPTPLVQNQQQTQHQQQLNWNTITAANAPSYTTTHPHSPHSRKQSSGISFSPSHSPPTPAQAQRMRSPDAPYDVPKHFRVHTAALMSDCDDGKEEGTGSRRRSSSKVVLLRKLRGLGYEWDVQTEYLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB10</accession>
    <name>A0AAE0JB10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_473141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679605.1">
        <property type="nucleotide sequence ID" value="XM_062827183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB10"/>
    <dbReference type="GeneID" id="87864337"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="645" mass="72399" checksum="9172E2657C6DB924" modified="2024-05-29" version="1">MAASSPLTDLDGTSTPASFHTAADSPNAADTTNITSPDHEDDQKPKYYKCKEIPHVLKQSCQIHLEEQMYLPAIDLLGSLLSDAGEGQQPDKPVRVPPPAQIALLGTLTIHPAYTSRAPEQANLDIAAESREYLRTLLNKVGPVNADFRSAFSFRQGQNSGRWARRNSREFNSPGESDGGGSIGSFSEADNIESKWSGNDHSIWRRSSDFWSVLGWAFRCSTTHPHRWVHWKAWLDFMIECLEKDWDERLAQDQANFQAKINRSSDPGSEAKCQYPLLQQSLFVQYVDDLRRDRKRVLHEVIRALFAFADDENTADNTYYREVFNKETVLHTDKSNKRKHSHMTAVDLEKDQFGDYLEDWDDPVTDDDDKADAFHTPHLPSARTGRRTKGRPRSTPFSKPGKAFDVSPTTTPNPLRVTDGLADSIPLRLRLFRLISACAYYLPPDILSKPKDLYDLFSSRLKSLPLPCFELFLSLDHVDLALPRYIYVSLFRYVAQSFTPRNAPQPEDADPEADADHAISQTMLRECFLPYPAKTVTVEDNAKFSLVLESMAWCLFQSGSVDYFDGLKWAVEKGIEEREKKIKKGNGRGGAAMTAAEKMGRQVLERSAASLRAFVDAVETTSLAEDGVIGTGDEMDEDSIMVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB69</accession>
    <name>A0AAE0JB69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic peptide chain release factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_510888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679782.1">
        <property type="nucleotide sequence ID" value="XM_062828441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB69"/>
    <dbReference type="GeneID" id="87865595"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3340840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="434" mass="48681" checksum="8D4FDAE8AD8985FA" modified="2024-05-29" version="1">MDPNANEAEKNIEIWKVKKLIKRLEAARGNGTSMISLIIPPKDQISRAAKMLAEEYGTASNIKSRVNRQSVLSAITSTQQRLKLYNKVPPNGLVVYCGEILTSEGKERKVNIDFEPFKPINTSLYLCDNKFHTEALAELLDSDQKFGFIIMDGNGALFGTLSGNTRDIVHKFSVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAELAVQCFITNDRPNVAGLVLAGSADFKNDLNASDLFDPRLQTKVVKVVDVSYGGENGFNQAIELSSETLGNVKFIQEKKLIGKYFEEISQDTGRICYGIEDTLKALELGAVETLIVFENLEVNRWVLKDSNGSEVILHTTKAQEQASRDKFMDKETGQEMEVVSQESFLEWIAEHYKDFGATLEFVSDRSTEGNQFVKGFGGIGGILRYKVNFEQLADVSDDDEYYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBD3</accession>
    <name>A0AAE0JBD3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_274210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679815.1">
        <property type="nucleotide sequence ID" value="XM_062822789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBD3"/>
    <dbReference type="GeneID" id="87859943"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="81"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="315" mass="35228" checksum="3F4ACCD7FF716E37" modified="2024-05-29" version="1">MSDQTPAQEEFASFLAKNSSTKYSSHPEDRDDYHDSKAFHSDDQADSEDEDEEDRFRNAQIEAAMRMPTMDSRTEIRLPPAGFDAGASTGVKGVIADARAYETAKRSAKWKDRVRNARRSVFGGGGDASPQQNSSSGLDSDFGSDAGLDSMDEDEKEFLDKWRESRRRELEKSSMNPASRQRRTSPSSRQFGRLDNVDAMGYLDAIEKVGPETAVVVFVYDHECPVSAAIEIALRPIVHSHPAIHFVKVHYAEIEFDNAAVPSILAYRNQGDLFANLTGLIEMIPDDEDFDSDTLKRLFERHGILRSQRGEPAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBF6</accession>
    <name>A0AAE0JBF6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_272882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679779.1">
        <property type="nucleotide sequence ID" value="XM_062822767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBF6"/>
    <dbReference type="GeneID" id="87859921"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22668" checksum="A1D7C596B1286A48" modified="2024-05-29" version="1">MDRKSKDERLLKAITSADEASLRAVLLALSAESDDTRDKISDRLLSIEYFNSSTPSTAGVKRKAPSPVYICRRCGDAFDEDNNRKSCLFHSEHMVVNPSSSVWDHWSYNLQGPKDTPKNRKNYRLIGGFKYSCCDRSADPVEGIGCRRGYHQAADGKRGRSGIEDSEDEPCPSEWDEDELDEDDDEDDDEDDDEDEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC68</accession>
    <name>A0AAE0JC68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF21-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_468442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680294.1">
        <property type="nucleotide sequence ID" value="XM_062826961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC68"/>
    <dbReference type="GeneID" id="87864115"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="62"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="327"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="610"/>
            <end position="668"/>
        </location>
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        <location>
            <begin position="694"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
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        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="715"/>
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        </location>
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            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3342501.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="83422" checksum="54B58E07EA6E3BC2" modified="2024-05-29" version="1">MSIAPRTAQHFRGASSRSNGLLAARSLTVGLARALFMGISSVTAAPIPLGILEHGRSEEPEEGAGLWVLYVVSAVLVLVGGAFAGLTIALMGQDGIYLQVLARDLTEPQQKNAKRVYDLLQRGKHWVLVTLLLSNVIVNETLPVVLDRCLGGGVAAVIGSTVLIVIFGEVIPQSLCVRYGLPIGGYMAKPVLLLMYLTAPVSYPIAKLLDKLLGEDHGTVYKKSGLKTLVTLHKNLGDVSERLNQDEVTIISAVLDLKEKPVANVMTPMEDVFVMAEDTVLDEKTMDMILSAGYSRIPIHETGNPTNFVGMLLVKILITYDPEDCKRVKDFPLATLPETRPETSCLDIVNFFQEGKSHMVLVSEYPGEDHGALGVVTLEDVIEELIGEEIIDESDVYIDVHKAIRRLTPAPKARITRRASEDIIGKTMSRGHDDVAGSSKTNGVDIPPSKIVEPLTGAGSTVSEAAHLINERDPKQTTFMMRRSSAGVDGQMVNTTVPVRANLEELRQHLKHLGPSNPAINPKNTRSTTVKIKPGIAGHLSQARAASIADSSAVAETPFEDDETTSLLRPQQSTAKDGIQALTQSYGGVSPATAQLISPAESAITAVPISVDNSDGNQDTVDKSTQTPPRQQQNAATDTAGGLSGHRSSGSSVASLRDSGLLPPRRGIVRSGSITENIIETRGVRKVVLETNSSNDEEEYAITTTSPDHGRGTKVTLSIAQPSARSETGDESQGLMSPTTGDEGHQSGDKGDESAKTNGGGQSSSHGKKHKSKKKKRKGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCD8</accession>
    <name>A0AAE0JCD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_223662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062822087.1"/>
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        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
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            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="10"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3342572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33002" checksum="FFF503F88FB7D778" modified="2024-05-29" version="1">MGDTLEKPDFRPIFNPTKQRPLGSPPPKEIIIKDAFRLRTLMAMGALAQILLFAILPYRYAVVPALILALQSIGSTIGQMLFYKTNENPFMTGVVQGITSGQPPSWQTGRYPNAPCSSPIVVFHLGVSYNHPLGPACPGGNEFYTHFMNMIKAMNEKKEEYGLLGMSNWKQTKRATHNAGLVIMYFRNVEGLHKFAHDKEHRDGWDFLHDFRKKGYNHITALHETFEVPAGAWESIYLDSPPILMGDTTIKVTEKDGSSTWYKSLVDASVRPLTGMMNRMARGKATARERYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCH3</accession>
    <name>A0AAE0JCH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_430764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679732.1">
        <property type="nucleotide sequence ID" value="XM_062824900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCH3"/>
    <dbReference type="GeneID" id="87862054"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="79" mass="9364" checksum="3E27C95541725292" modified="2024-05-29" version="1" fragment="single">FLANFEDEEDLYYKFTRKATLLSYNKNFVPFKIYSKKRAKKVRRGSNLLIKFILSNKGINILSELPIIYLYLIGVKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCN8</accession>
    <name>A0AAE0JCN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_526783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680490.1">
        <property type="nucleotide sequence ID" value="XM_062828862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCN8"/>
    <dbReference type="GeneID" id="87866016"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="279" mass="31451" checksum="A136EC9E4535AD1D" modified="2024-05-29" version="1">MPKRTLASARGAHSDKAQGINPNKRLVGMNIRTVPQRMTAQAEPSGPGEEPEEEPAEEEPEEESEEEPAAKKRKTTKAAGGKRKRASNDEDENEDEDEEEAEEESEAERPKKKAKPAANKKAGKGKGKSPKKKKKASNKAKEPEEPEEPYNPNQLWAVRDIISQRTTSEGVLQYYVDWEPTNGRKWDPTWEPAENVVDTSPEIIAEWEERRAQRAISEEEVMAEAVDPDDIEVEDVPEEEMPDEEVRREIVYGRRRAGPKPMTKSKYPGKKLVAMTAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCP8</accession>
    <name>A0AAE0JCP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_589746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680545.1">
        <property type="nucleotide sequence ID" value="XM_062831046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCP8"/>
    <dbReference type="GeneID" id="87868200"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3342752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="632" mass="70325" checksum="2DDCC868AB4820CD" modified="2024-05-29" version="1">MSDPVIRTASPYTDPNVKGPRIQLLSSGQSSSLINNKSSNSKYPNFKLSSLDNAHAYTLHIHLAYNAPHDQWSSYLLNHDHVNKTNLHPGGVKPQVEHTELEEELHQKAHIDYDRVAIIANPSVASLYEDALVYETGTAITSSGALTAYSGKKTGRSPSDKRIVKEPSSENDIWWGPVNKPMSPEVWKINRERAIDYLNTRNRIYVVDGYAGWDEKYRIRVRVVCARAYHALFMRNMLIRPPREELEHFHPDYTIYNAGSFPANRFTEGMSSTTSVAINFADKEMVILGTEYAGEMKKGVFTVMFYEGPVKHNILTLHSSANEGKDGDVTLFFGLSGTGKTTLSADPNRRLIGDDEHCWSDRGVFNIEGGCYAKTIGLSAEKEPDIYNAIRYGSVLENVVFNPETREVDYDDATLTENTRCAYPIEYIPNAKIPCLSPNHPKNIILLTCDARGVLPPISKLDSAQTMFHFISGYTSKMAGTEDGILEPQATFSSCFAQPFLALHPMRYAKMLAEKIEGHNANAWLLNTGWVGAGFAQGGKRCPLKYTRAILDAIHSGELANVEYENYEVFNLQVPKTCPGVPSELLNPKTAWTAGADSFDTEVKKLGGLFLENFKKYESEATEDVIKAGPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD15</accession>
    <name>A0AAE0JD15_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="5">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ5</name>
        <name evidence="7" type="ORF">B0H65DRAFT_469264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD15"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3342765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="345" mass="37751" checksum="1B6243E8F4F2E8FE" modified="2024-05-29" version="1">MVARPALRRAIPSSLRSTSSKLLHAESRISRPFSTTLQSQQKPNNNNNSVPEYAIPDPARPTHFGFETVTEAEKRERVAGVFTSVAESYDRMNDLMSFGWHRVWKDHFVASLNPGFSPLTSSSDPRAPQHILDIAGGTGDIAFRMLHTAHILNGNPDVRVTISDINPAMLSVGKQRSAALPASQQAALSFLEANAEDLTQTKPLGANQVGYSPTTGVPDESVDLYTVAFGIRNFSNIPAALREAYRVLKPGGVFACLEFSKADAHPLFNTIYKQWSFSAIPLIGQLVAGDRDSYQYLVESIEKFPSQEDFRDMIVDAGFVVGGKGYEDLTGGVAAIHKGMKPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD42</accession>
    <name>A0AAE0JD42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_231243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680618.1">
        <property type="nucleotide sequence ID" value="XM_062822185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD42"/>
    <dbReference type="GeneID" id="87859339"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="122" mass="12342" checksum="A510267FFED8E5AF" modified="2024-05-29" version="1">MPREGTRSSTGNSKPRVFPVVDTAPAVKRTTKPKPAAAEEPKAAPAKGAKPTGVTKKAAPKKESTVAKKVKAVADKVEKKAGKTADKAEKKAEKAAAEPKPKAAPKKKAAAAPAAAPAATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDI1</accession>
    <name>A0AAE0JDI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_540658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680940.1">
        <property type="nucleotide sequence ID" value="XM_062829160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDI1"/>
    <dbReference type="GeneID" id="87866314"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="258" mass="28485" checksum="3011B8D1FC31D8ED" modified="2024-05-29" version="1">MPLSMPPRQEAGMPNKGLLFRTGSPGRLTALERGTSQVDDNSNNYDNSSYDNSSYDKSFECLGFEWVPQYLPYEGSGFYLDGQFPDLSANTQNTCDAAYQTSQAYNGLDWQHLDSHLPLQQITTLIGNDSDVSRWVSSPIPRSMIQGLPLMQLDMTSSPLVDMPMQSWDLQYIHSSGPPMNEEQLTAILQLGQDTCACMSPFGRQTTGSTSMAHTPDMAWQTGTGSNSSTSPISSNDDQFICDYPSCKATRPSQKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDQ3</accession>
    <name>A0AAE0JDQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_428442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681045.1">
        <property type="nucleotide sequence ID" value="XM_062824761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDQ3"/>
    <dbReference type="GeneID" id="87861915"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3343252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="259" mass="28194" checksum="A255D4317E88A6AB" modified="2024-05-29" version="1">MAWHSSGVSNSELIENLWRNKLIKEERVKEAFLKVDRAHYSPTSPYSDSPQPIGHSATISAPHMHASAIEHLLPSILPSPSRPAPRVLDIGSGSGYLTHVFAELVGSEGGTVVGLEHIPALRDLGARNMAKSAEGREFLDTSDSASTSTDSHAASAAGRRSSVNQRNPMGEVEGQGERKGEDKDEGKWDAIHVGASAREIHKELVDQLRSPGRMFVPVDDDEMGLQQHVWLVQKGEDGEVSMRRLFGVRYVPLGDPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE78</accession>
    <name>A0AAE0JE78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_508559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681325.1">
        <property type="nucleotide sequence ID" value="XM_062828233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE78"/>
    <dbReference type="GeneID" id="87865387"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3344712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52803" checksum="3E75086809E8F1E1" modified="2024-05-29" version="1">MFFGRKAAMAPLDPTDRVLPLHFFESSVLVQKCNVAVSMVFDEVLDPEKLKTSLESLAAGKTEWHIPQKFTAERPAINYVHVDHGMPASAHPAASKIPVPSARPCVVGDPDLLADLAWEAGYTPNGITDYLTEDKPVLGLRVNSFTDKTVVVLQWQHVTFDTLGLQYVVDAWQLILHGRGNEVLTPCGIDGDPFNPLATGSAVATEEHVLNNRRVGLGGILKWGLGYGVDMVLRAKDNGMVCIPESYWRPQYEKALEELRAEAVEKGEDPNKVFLTENDVITAWIMRCVVESMNMDPQRTVAGSIAMSLRKAFEGDLIPYASEAPYVGNAFGWGNVLVTAGDVSTKPLSWVARQVHRAINEQGTRQQHMAYYNTVRTSNTGLPIIIFGDGGMYQIGFTNWSKANLFEVDFSLARKQAKNGQCRPSYVQENHGPVKPCDGFVILGKDPKGNYWTAAYKLKGQWIKFQEQLDKDFAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE87</accession>
    <name>A0AAE0JE87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_183951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681345.1">
        <property type="nucleotide sequence ID" value="XM_062821542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE87"/>
    <dbReference type="GeneID" id="87858696"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3344732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="359" mass="41220" checksum="1E5036A676F6D472" modified="2024-05-29" version="1">MSDLYLSRIRNWFLSSPPAEWALKGLRETLIGALKQGPIPRHVAFVMDGNRRYARSHKIETIEGHHLGFEALARVLEICYKCGVEVVTVYAFSIENFNRPKYEVDGLMQLAKVKLEQLIQHGELLERYGASVRVLGERDLLSDDVLEVIDRAVSTTKNNKKCILNICFPYTSREEMTTAIRSTVDEYSKSSAPKSTPFSQTRITQKIMSKQGDRSEKSESDNSSSGQEPTHTPPGSDDNEDSMSSTTTLYPESPGRTSKDSSNNVTIYPNAENITTETIDKHLYTADCPPLDMFVRTSGVERLSDFMLWQCHQDTQMFFLKCFWPEFDLWHFLPVLLEWQWRQKKKAMEERPRQRVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF32</accession>
    <name>A0AAE0JF32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_577359</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681097.1">
        <property type="nucleotide sequence ID" value="XM_062830691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF32"/>
    <dbReference type="GeneID" id="87867845"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="224"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="462"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3343304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="704" mass="77261" checksum="6144421E32A9D053" modified="2024-05-29" version="1">MVETRRRSARIADAKFDPLEYHTAPTNADSDPNPDSDSSALSDIDESEFDSDARPSKRRKTASGQASRAVRKTRSTTVKTVTTKTVTTRTKASATTTARTSTSITATLTTTTKAKPKSTAASIQALITQLFDGALPQKHELPCLPSNPHSLTYHNPLLFSSSTARTTRDALLTWFDSVSSDRQMPWRKPWIDTTSLLSSASACPQDLREAVAQRAYEVLLSETMLQQTRVSTVIPYYNKWLAALPTMQSLAAAQPEEVLSLWKGLGYYSRATRLHSLAQLVCPPCSQGGYDGLLPHTVAKLMQLPGVGRYTAGAVASIVYGRAEPMVDGNVIRVLARQLGIRGDVKSKKVLEVVWEAAKHLVEAAAWDGTDATDEERKGKEPQVSDRPGRWGQGLMELGATVCLPGPAKPKCGLCPIKETCRAYQEGVEIATQKGLLPGRKVTETKKGMGAGEMVDIEDSCTLCPPPEAEDLEKSAAEDKPDEKKGKKKGGVSAFFDKFKGPGTHRKKEVEDDSDSTGPSLAAMEVITSHCSKYPYTKPKTKKLREEECLVVSIRRQSDGCYLIHKRPAKGLLAGMWELPSHTLPADSTWNDEPSTKKMNKVRMVLKEVLKEMGVRQWRVRYWEKEDEELGTVPWTFSHFKLMMHVWAVDLVEGGDVGGERGGGDAKMKRWATVEEIEGENMGTGMKKCWELVKGSRDLAGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFW7</accession>
    <name>A0AAE0JFW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_209540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682195.1">
        <property type="nucleotide sequence ID" value="XM_062821913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFW7"/>
    <dbReference type="GeneID" id="87859067"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3345582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="464" mass="50388" checksum="1FC1A8DC78C4B72A" modified="2024-05-29" version="1">MNRSPSSSGLLPLPGAPSSSWALYRARLSSLLQSVDTAVFVAFWLFGLINNVLYVIILSAAQDLVGNGIPKGVVLLADVMPSFLTKLVAPYFIHRIPYATRIFIFVALSSAGMLLIAFTPPSQSVAVKLIGVGLSSISSGGGELSFLGLTHYYGHMSLAAWGSGTGGAGLIGSLLYVMLTDWIGLSVKTSLLASAFLPIIMLVSFFLILPHGPLRASARKTYEPIANRDSFQEEREGVEDNFGDIPTSTASSSLLAPGPAVAATVYSSHPTEDARKDSLAAKIRRSKLLFFPYMLPLLLVYIAEYTINQGVSPTLLFPLDSSPFTEFRSFYPFYGFLYQVGVFISRSSIAFIRIHHLYLPSLLQVANLVLLTLHALFNFIPSVYIVFVIIFCEGLLGGGVYVNTFAEIMENVPAEDREFSLSATSVSDSGGICVAGFLSMAMEVWLCNWQVDHGRDWCRRIKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFZ3</accession>
    <name>A0AAE0JFZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_465109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681577.1">
        <property type="nucleotide sequence ID" value="XM_062826791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFZ3"/>
    <dbReference type="GeneID" id="87863945"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="122" mass="12434" checksum="A599C00F26A8BC2A" modified="2024-05-29" version="1">MADGGPSPLTPGVPAGMDALSVADGFETPDTPSKSTFGGNTASSKKRKTAAGQTDADAILMEETPAKKKAVRKPRMTAKQKAEAAKAEAAAAGHVSSDYIVVGMDEDGVSQVEEAVIDPCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGE2</accession>
    <name>A0AAE0JGE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_147602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682450.1">
        <property type="nucleotide sequence ID" value="XM_062821027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGE2"/>
    <dbReference type="GeneID" id="87858181"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000014">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="139"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="285"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="431"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="612"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="804"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="967"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3347368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1128" mass="125531" checksum="47646244F669AD47" modified="2024-05-29" version="1">MEPGSAKRRKIGHSRGESAVGNIDAAASSGLSRGRAFILEAEELLDQVKLDYATALEGVDSLLHKIKGSIEAIEAHDALQIAEAATKLEKKHKIQIPFPEPRPSDKSNYKVAFAKPSQFNVVGSYVSKTMIKAQKSHAVDMVVVIPGETLQEKDYLDLRYLYKRAYFLGVVAAALQKDLADDGELSYEYLNGNPLSPILSLKPKVEGEKKEGRLDYRVRIIPCAPDALFPKSKLHLGATLVRKAGGDESKAATKPTPFYNSTVASESCFFPYLKLLRQTEKKCAAFKKACILGRVWLQQRGLGSDMADGGFGHFEWAVLLALLLQSGDNTRGHAPLSTSLSATQLFKAMVQFLSVTNLSEKPCVLGTATLESGTAGPVLFDSVRGLNVAFKMSNWSAAKLHQHAKWTRSLLNDSTADQFTPTFILKADLPWQNYDLITHLNYDGKQDKTQPIDCRGRVWEYSDKVHRVLKRALQDEELGERARSIHIQLPKSSSWDLTKKSSTKQNHTIEIGVLFNAANMTRAVDRGPAAGPSNEEKEECAKFQRFWGEKSELRRFEGDSIRETLIWSSTSSFDLCEEIMRYILKLHLRVGYLEDELTFHGDGFTELIPIKPTDTSVFNAARKAFSSFEKDIRNLDDMPLHVRQIAPICPELRHASVKVPFSTVTKSGPRPLECVISFEASGKWPESIVAIQRTKIAFLRMIGDLLERSKPGEVRTYVGLESSTTTNTELENLAYLDVVYESGPAFRLRIHSDLEEALLTRQSHDKTIDQHHRHQASVLLSNFRRLYNHLPLHTQSINTFATRFPAFSPTIRLLKHWFSAHKLSSHFTPDFIELVALQTFLSPYPWDAPSSPSIGLLRALLFLSRWDWRSEPLIVDTNGDMPSSKRSAIATRLEAWRKIDPLMNHTVLFVATAQESSGVAYTTVNGVAQPSKVVAARMTALAKTACRVIREEGVELDARRLFVPSTKEYDVLLHLSAKSLKSASKVYPSEDLTSTTKSSAGNSRYKNLSTHATEDPLPLPTSPIDSLFEKLEQVYGSGSSAPLVFFRGGEDEKVVGAIWNPTLSRRGFKVNLGTSYKPVGAGKKRKGDDEDGEEAGGEVMVEVNRDAILSEIARVGGELVERIEVQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGS4</accession>
    <name>A0AAE0JGS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_521725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682664.1">
        <property type="nucleotide sequence ID" value="XM_062828760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGS4"/>
    <dbReference type="GeneID" id="87865914"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="238" mass="27444" checksum="3CE75270D6EE5634" modified="2024-05-29" version="1">MASPAETSVTYEELRDLENEFEDVETEIIRQQVQLSRPLYEKREKVVAQIPNFWPLVFEQAPQDIDEYIQPQDSALLLSSLTSFSISHFEIENGGSGDPRSVLFRFEFAENEYFEDKVLEKKFWSRRSKGGWTGLVSEPVNIKWKKGKDLTSGLLGLVNAVWEEEKAVGKHWSTVKGEEFTDKQKELKDQIEKIGLGGLSFFAWFGYRGRRVSAEESKAASEKLQEQLFFCCCCCCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH10</accession>
    <name>A0AAE0JH10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_460617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682568.1">
        <property type="nucleotide sequence ID" value="XM_062826544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH10"/>
    <dbReference type="GeneID" id="87863698"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3347486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="468" mass="50034" checksum="BD8F842CAD01552D" modified="2024-05-29" version="1">MKPNTTLLCGGFGLCGVPDTLIDEVIHKPEITGLTAVSNNAGTDASGLGKLLKTKQIRKMIASYIGENKTFEQMYLTGEVELELTPQGTLAERCAAGGKGIPAFYTPAAFGTVVQTGELPLKNKPDGTPDVFSYPKDVKVFAGKSYLLEHAIAGDYAFVKAYKADRLGNCQFRLAAHNFNGAMGRNAKVTIVEAEHIVEPGEIPPEAVHLPGIYVQRVIQSTAEKKIEKFTFAKDPNDPEAKKALGSGEMANKRERIVRRAAKEFKNGMYANLGIGMPMLAPNFVEEGVEVLLQSENGILGLGPYPKKGEEDADLINAGKETVTLAPGAAVFGSEESFGMIRAGRINLTILGAMQVSANGDLANWMLPGKVKGFGGAMDLVSNPEKTKVVVTMEHTDKKGNAKIVKQCAFPLTGKACVSRIITELGVFDVDFGKGLTLIEIADGVTVDEIKAKTEAPFVVADDLKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH97</accession>
    <name>A0AAE0JH97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_547658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682930.1">
        <property type="nucleotide sequence ID" value="XM_062829532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH97"/>
    <dbReference type="GeneID" id="87866686"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF18">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041984804" description="LysM domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3347848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="161" mass="16402" checksum="030A771A36955541" modified="2024-05-29" version="1">MGFASLLMLGVVPQLVAAHVLQARQSVSCDFATATNNSDTCASFAAAWGITEAAFAKLNPGVSCPGNLIAGTEYCVIGTVSTGAPTTTKTASTTTKAATSTTPPTTTKATTLPTTPVSPTGPSPQMPNITSTCNKFYQVQSGGLRTQEHVVHLALPTSRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHC4</accession>
    <name>A0AAE0JHC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_571282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-232 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682995.1">
        <property type="nucleotide sequence ID" value="XM_062830478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHC4"/>
    <dbReference type="GeneID" id="87867632"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3347913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="344" mass="36944" checksum="A585B6B897306FDD" modified="2024-05-29" version="1">MSPSVLEPQSVPTLVNVGPKAVGKNDATVERDARGLSKPLLELMPTLGTDAFTFSPIRESTVSRAMTRRYFADLDAHAESDIVIVGAGSCGLSCAYVLSTLRPDLRITMIEAGVAPGGGAWLGGQLFSAMVMRKPADVFLDEVGVPYEDEGDYVVVKHAALFTSTVLSKVLQRPNVKLFNATTVEDLITRKHHAESSSSSDDGEAEDEAKVRIAGVVTNWTLVSMHHDDQSCMDPNTINAPVIISTTGHDGPFGAFSVKRLVSMKQMERLNGMRGLDMQPAEDAIVNNTREIVPGLIVGGMELSEIDGANRMGPTFGAMALSGVKAAHEAIRVFDLRKAQNDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHU6</accession>
    <name>A0AAE0JHU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_571752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683232.1">
        <property type="nucleotide sequence ID" value="XM_062830489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHU6"/>
    <dbReference type="GeneID" id="87867643"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042025434" evidence="3">
        <location>
            <begin position="26"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="67"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3348150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="245" mass="25841" checksum="BCE893C33F52DB44" modified="2024-05-29" version="1">MCFTRFIKHPLTAWLFGALVQAAFAEEAEDAVQPNTAVPILVPQVDPANTNVVTGIAVSYPAASTTPKSSTSSINSINSEEEYETEVPSLYTTTTTITTTSTKTGTETVESSVSRSLTSSSSLSLPPEANSAATVTKRAPDTTSTNSSGNKHFIPSAWRSYQSAHFNKSTATTKKTTTTSETEVGSNTHTPCSDFPILPPKDIDVGNKNDSWSDRETPSMMNVFGAAALAMVVQAGMVFGGGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHX7</accession>
    <name>A0AAE0JHX7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_570441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87867605"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1772"/>
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        </location>
    </feature>
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        <location>
            <begin position="2045"/>
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        </location>
    </feature>
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            <end position="2187"/>
        </location>
    </feature>
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        <location>
            <begin position="2196"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2226"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1566"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1699"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1806"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1843"/>
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        </location>
    </feature>
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        <location>
            <begin position="1927"/>
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        <location>
            <begin position="1971"/>
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            <begin position="1990"/>
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    </feature>
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    </feature>
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            <begin position="2163"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="2203"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2226"/>
            <end position="2244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2274" mass="253678" checksum="93A00C92D9E07286" modified="2024-05-29" version="1">MPWGIPFFRNRTENQNQKKRGSSSKSPKNANKPINSSSTNRVTKPRPRASSTGNLEKSTKSASTTIQKAIDSAGSSKSVPITNPYASRLFGTDPSNLTSFNLQRPNPAAVTLSPSELAIQKRDQRQADLAQRKAQEEHDNQLRLASYRRVDPTVTPSSDVFQTILYSIRNHLDSPTSTLNELLKARFSPEDRDLLLPADWERNPVLAELQGKNSERYSRLVKGEVKGWATKKESTSSKGSSTKGKKGDKKKGEGEENEGWAKEADLAFKLTCLYFGLPVAPMGWEQSETRRWWEKKMMKGVTQKGGYGAGYDEVEDDMGNIVRRPREDPIKFLNCYGKRVFEKDAVREPDPVLETYNALPQFPETLRELDPEGDYINADALRAVLPDKLDFSFGLRGGGDFDDEDEEVVDEEEEHSMDVDEPVELFPSPENALVSLRGGGPLKDIGEVFKDIDRGKYRLSTEAYYAFAQTDNHKDGLKSRLEGERGGVENLWIPLYGYQGIVWFHIGMLNTFVDAVDRLLGFGVRAGASYKLYLFDRNKEYKTRAQKEAFSRNNRNTLDVACKGPGDYSNDHIAWNWVIGHLGSLGHDTNGSPLARQKVLFVAGPLDPVPYQWEPTDVHNVAKLVLEWDGMPDMNRPDVAYLRMPIAGDPSTVDVHTNQFAPWMAQVCRVLCAGRIPNRPGQPFVPDAYIGVKVTSDPRYGGDDNDDGTYGGLTFNFDQWLSILQAHKDSRNQPIVLRAWTSESPSGNIDRWHMFVPGVSYQYSDNCAILHSEFKDSKLVHAKIRNMLESGLGLEQLQDLEHIEVHLPGESFLADAREQSEVLIPVDSNGKLDKQGVQRLAELLEQWYNWLKEKPGVPPAKNGVDMFPQFITLQPVYREYALVCDEDHEQTLEWNPRETSLAEFRGLVEELWSPGRFSVDYYPESSRVRLTQNELEGAPMLVVLPTTTELEWYKIRDMVVWPELVVQVYDDQLDVFGDIYAQPFGYRDIYKTKDADVLYSSLSNKDDLPNANSLRFGRDYQLWAEEVPWSHGELRTIQPSDRQPQPAPGTTASQQSRTPQAAVEVNQHNTNPMGFASNLPPPRPTHTGVFSASRKLDLNAMNPSEKGRFLREFSYANPLTVDFVKGIPVHIPPIDQLLDCKFDSTPRLANRVLTPSEARLLQQKYFEMRTIILEREEKCHFPGCDAAFPYSSGLMARHIKAAHTAEKCNFCADPLYQHWTVAQRFQHFASKHADILGALQTTRPINGASANDDHPNPFQFQRELTWGFCCRCGRDHSVLASKLDRFHHDLVCYPGAAHHEIHPWKACTVCGERIHTDDPSSAKAHKHPDVARGAGTGYKPDFCAQCGLELRKLEVADREKHAHFCRGHCGGKGRNSSSFNVRFCPWCGLEMEMTTSTSADGNGNGSKTIDVVAAQRHIDSCVAKPEDDKRTFGPIHPVSHLAYYYGVPKGAKTARVDVPEGVIPLKQWLGRSAAMGGVGERKPLRAKKGERVGPAGARDLTMGTVVPAGIFGNATQGGPGPATTAAKRARFADVVEEVEPEEEDEDEDEEMSDLSILSEDEPAGKKAGKRPARAGGKRKRAPFTSDDPTYKPTWSWDPSDHSSEFMSDDESAPRPSAAKKAKTVAEPEVKTTPKVSFRPTGKGGKKKLAPFQSEDPSYKPPKGYSNELDESDLSDVAADPLDISLWPQPHEVVKFPGDDVVDEPEDEEEEEREPAPPPATKGKGATKNITATKPPRPAKTLALTAAAQKAAAKAAAAAQSSFVERIILPAPKKILPTIHGIREPNSDATTSSSEDEEDSDEEPKKGKGKGKGKAAAKKAAPKKAAACGRVTTRGKAKQAAAVDDSDEEGEEDEEEEEGEEAQSPVSATALDQDIEDEEGPPANPPALKAMKVKALRAPDSPTATGTRSRGLNAKMMQLPSGSGGGESSSLSKSSNNTNTNSPSKPRSRGRGRPKVSLSPNPRLFGKGTSPDPLQSPTSPSRTRHQARTDSSPSSSSSQTQSRLAHLNHLKARYAKLQTSPPSPPSRIEFDSPLVTRARESRMMRDAYTGASPSAPVHPGSPWAALQKQAESQEREDDEYYAMAIDKYYQKIEDEQDRLLEEIEREERLLLQTESRDRQRERERERNNQKQKEKEKEKEREDLEKEFERVKQLQAEAARRQIRQRAETQEAMEAREAAEAAEAVEAVEAAERMERIQRKREVEHDEDEDEDEEIEQEWEEYIRRVKRRKEEERRRANERALERLKGRGQGQMPPPGRVTDEDLEALARSYPGTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI53</accession>
    <name>A0AAE0JI53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_588049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3348212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830995.1"/>
    </dbReference>
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            <dbReference type="EMBL" id="KAK3348212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830937.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87868091"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3350385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="279" mass="30324" checksum="25A0920BDD6CA44F" modified="2024-05-29" version="1">MTAFDEGEKAIYKAAAFPRCILFPEHGTSSNASAKRRCVNAHYRESKAESIPPVWSPPASTTAPVYPPMLPSALSPPSAQSYFPAPAESYSPGYSPPHASTPFNMRAASQRDLPIAWKTQLAVEKPSFRIKEMLIYYLTGDEIPNSYLCSLPGANCRQKFMTVGPAVDSMEQENLAIYKDGVFPRCVLFHSFSGKRNCCNATTLGDRAVDGPAHGVDDLMAAAGLEVDEVKGFIAAGDGDWLLGLRSGQRVRRGDRFLVLVPAIGEEVGALPEVRRLKN</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683784.1">
        <property type="nucleotide sequence ID" value="XM_062824287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIX7"/>
    <dbReference type="GeneID" id="87861441"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="787"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
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        </location>
    </feature>
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            <begin position="104"/>
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        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="227"/>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="735"/>
            <end position="750"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ29</accession>
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        <recommendedName>
            <fullName evidence="5">Questionable protein</fullName>
        </recommendedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683890.1">
        <property type="nucleotide sequence ID" value="XM_062825429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ29"/>
    <dbReference type="GeneID" id="87862583"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042084547" description="Questionable protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15565" checksum="E01F5C85C8151B16" modified="2024-05-29" version="1">MGFELFACPTCLLLSWYVSPSSITRYLLSFITYTDNAPQLLGSCLELPGLPGTAKARTSTNAKPCSPPVGSGWPSGELPHHFRPPIVPDAHPRGGPELGCQASNCSGKCPFQSTKSTEWPPTDDRSPPLTEQQPPTATATGKINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJK2</accession>
    <name>A0AAE0JJK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_456078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684132.1">
        <property type="nucleotide sequence ID" value="XM_062826272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJK2"/>
    <dbReference type="GeneID" id="87863426"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000601">
        <property type="entry name" value="DNA repair protein Rad7, protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000632">
        <property type="entry name" value="DNA repair protein Rad7, protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="607" mass="68020" checksum="C8E56CA52A994459" modified="2024-05-29" version="1">MSRQQNNRSSRQIRGPQSALTDFLASHNISANQIRLDADARRRAAEQENGASSSNQQQAAEDEVGESSTVTTSVTVTTRTSRRKKDQMVIDKIKASKTYQKRKRNADEDDEDDDLLDTLLRERAPLPGQMDNCANCGKRFTVTAYSRNHPDGGLLCSPCGKEMDKDAPPKKKPAKRAAAGPVGRRRQIQSKILDGTFQLGAKSLMTLCIETLAKNIDLAEDLGDLPQPVIDKIARKLSKHRLLNPTTLSLFLQPTTDEVCIYDGAKLSADDYIRIFQTVPGLKKLKARNAIHFKDEVMDFLVSRKTELEDLYLHGSNLIDEEKWLEFLQKKGKSLQSLRVYWTDKHFGDSALAALPSSCPSLVRLKACHNQKITGEGIKHLAQLKHLKHLSIDLRNHVHSDVYVNVLSSIGRNLETFSITREIDLDNTVLDAIHNHCRSLQKLRITDSEVMTDEGFARLFTNWENKCLVFVDLQKCRQVDSANPRENPDNIGLCDKGFKALMAHSGRKIQHLNVHGCRHISAKAFEEVFPADGKKVYPELKNLEISFCEEVSDFIVGSIFKCCPNIHELNVFGCMKVKSVRVPKGKILVGVPNALGMVIEGVDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK08</accession>
    <name>A0AAE0JK08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PI phosphatase group protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_107232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684354.1">
        <property type="nucleotide sequence ID" value="XM_062820510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK08"/>
    <dbReference type="GeneID" id="87857664"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117089" checksum="F962F81F812931F3" modified="2024-05-29" version="1">MPSSEGPPPLSRTRTGSATTDPVDLATTNPHSLHQAIYARREEYTRPHRIRVKVGTWNVAACPGTDKDLASWFVDGKGIDTALATLDLNRNAAIEGNTDGEDGVHILGGDKIGLYVLGLQEVVDLNTASQYVSRVYAGDEGVTQKWKTALDAALPPGYKLVASEQMTGLLLLIYASPEVAPTISNVSTVSVGTGLLGYMGNKGAVVTRIILGESTRLVFVNSHLASGIEGTYNERRIWDVGQILGRTRFKPVSFAGVSEDYEEKIGDEDFAFWFGDLNFRLDGLPGDDIRHLLMLHTKGEYGAPRPKFRRDNSLEGEPIIVHADKSSDAGDETNDDKSTTTHSTGDTKATDYDTKAIDYESDSDLDALPDPDDFLPDPHDDPTSLQATLDSLLPHDQLTRLIKQKKVFHDGWHEGAISFLPSYKYDVGTVGLFDSSEKRRAPSWCDRILYRTRKDKEAYDKKIKDAEDARKKDEEMKARGIDQAGDDDEVLFDYDPDNDGDDDHSPGVSRLEYDEYDEGEEGDDQHNRDDWVDRIRQDIYTSHQRITSSDHKPIISIFTLNYDAAVPDLKAQVHAEVAWELDRAENEGRPSLTVVNDSRDARGPGRPGGSQDSAEELVDFGEVRFLQKQSATLTLANTGRVACTFSFVEKPSPAKEDGPNPPPWLKTSFISSEPAIDDSQLPDMGKEVTLEPGETVRARLEVNVNHVEQARVLNSGKDRLEEVLILRVTDGRDHFIPVRGVWMPTCIGRSIDELIRVPEGGLRKFVHSLTEKNGGKVMSVPEEMDVHCAAPRELFKLTEALEAVTERVLADEQMLEEYKAPRASGWPFEEDTWRVTDNSLRASRAADLIDALDVGMAHIVDAFTAEVPAVERLETVAEVLQLFLRGLTDGIITTSLWSRIEQASLVSLGQGATAASKVPPQETAYEDDKGTILDILSTAPNHNISFVFLTATLAKVTTDLSPITKSDLELLKSDTPVRLSMLNRRSLTAGLVKRNTSSGSFGQAMAAMAARQAKERSFAEVFGELVCRAPVQKGMKDKERKAVVEKQRAVLELFLRRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKA4</accession>
    <name>A0AAE0JKA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_456388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684218.1">
        <property type="nucleotide sequence ID" value="XM_062826288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKA4"/>
    <dbReference type="GeneID" id="87863442"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3350923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="282" mass="31099" checksum="322D146A9559D77F" modified="2024-05-29" version="1">MNAFIARTSLAPRHVYRQFAATTRKMHIKSIPMWTGSSDNYAYLVVDDKSKDAVIIDPANPEEVAPVLKKAIDDGSINLTAIVNTHHHWDHAGGNTKLRTALGLPNLEIIGGKDCDKVNKTPAHGKGFNIGSIAVKALHTPCHTQDSICWFMQDGDDKVVFTGDTLFHGGCGRFFEGNGAEMHKALNETLASLPDETRVFPGHEYTKSNAKFCLSVLQSEAVKALAAFADKHKETQGKFTIGDEKKHNVFMRPQDPEIQKATGETDPVAIMTKLREMKNNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKJ3</accession>
    <name>A0AAE0JKJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thiol-specific monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_546007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684226.1">
        <property type="nucleotide sequence ID" value="XM_062829420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKJ3"/>
    <dbReference type="GeneID" id="87866574"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3350931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54268" checksum="1DCABB1A01D1C66C" modified="2024-05-29" version="1">MGSQKPRRFNVKKIAIIGAGPSGLAAAKYLIAQKVFEDIVIFERQDEVGGAWHYSKEPTHTLHVPQVSAYCPPDPPLHPEGKPPLFPSPMYEVLHTNIPRHLMQFSDKPFPEDSLIFPSRELVQEYLVDYAKDIRHLIRFSTLVQDVRLRQDSDGRDQWDVDALTLETGEVTTTTYDAVVVASGHYYTTFIPDVKNIAEFHKAHPNVITHSKLYRTPEPFANKKVIVVGNSASGIDIAAQISRVSQQPLLLSVHSATPPAHLEWIGAEEVPAITEFLVEERGVRFEDGRIEKDIDAIVYATGYLFTFPFLKSLQPPLVNDGRRVYGLYRDLIHIDHPTLVFPGLPIKVVPFPFTESQAAIFSRTWANLLPLPSVEDMKKWEDEEAEKRGHAFHVWPKLGDANFINEVHDWIKRSGTKGKEPPFWNDELVWQRGIFFEAKLQFEIDGEKAKSLEELGFKYEPEEKESEKKTTPTETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKJ9</accession>
    <name>A0AAE0JKJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_104428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684241.1">
        <property type="nucleotide sequence ID" value="XM_062820470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKJ9"/>
    <dbReference type="GeneID" id="87857624"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="9">
        <location>
            <begin position="258"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3350946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="596" mass="64009" checksum="5B7A6C0F3BE8895C" modified="2024-05-29" version="1">MGQVSFMEGSNPESHYPESRVLIIMTGGTICMQPSADGLVPMTGFLKNAMAPRPSFNDPTAPNVQLRAYKNGAKLTLDSLRTPVSAYSRHIRYGILEFTPLLDSSSISSMGWTEIALTIKENYHLFDGFVVLHGTDSLAYTASALSFMMSDLGKPVILTGSQASIFALQSDAVDNLLGSLIIAGTFVIPEVCLFFHHNLYRGNRTTKVSASSFEAFASPNCDPLAKVTSLGVDVNWGLIRRPTRIAEFQVTKYLDTAHVACLRIFPGIKPEMVDSVLRVPNLRGLILETFGMGNAPGGADGSLTKVIKEAIDRGIVIVNVSQCTNGFVSPLYAPGTVLGRAGVVFGHDLTTEAALTKLSYLLALPNLTYSEVTAQMSHSLRGEMTEMALPSFSHPAGSIDSAMARLPAADAAFTALGYAIRSGDLRTVREILEGDEFNHQLLKRADYVGNTPVHLAAVGPNPDILHELLTRGASVHPRNHANQTPLFLAEQMGNMATVKLLKEAGAHLWRTEPHSGNASEAGDLASTTDVASVGAAEDEEEVGDVAERRSNEKEQKTSDQVADTVSPRDGLDKGSLVTDESLVHGLKKEDIGKFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKP6</accession>
    <name>A0AAE0JKP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CTLH/CRA C-terminal to lish motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_118135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684744.1">
        <property type="nucleotide sequence ID" value="XM_062820684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKP6"/>
    <dbReference type="GeneID" id="87857838"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
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    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="192"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="472"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="725" mass="79317" checksum="D353E1D557FC259C" modified="2024-05-29" version="1">MTNPNPFPRRMSSFASANNGSRPVRSAGFSHLLNPSPDSGGHGNGAGSHAGAPFSSLDAGAPHSGNTPHGLDEGGGSHRTSGGSLPSFSRAFDMFTSKEPLLAGPNVTYSGVGPSASVSKTGFLSPSYLRGSGYIEKLAEQHKAKLLADREITMSKGPSGTVFTGNTGNTENRSATLHTKLPSGTHRGVALNLIERPPASAEFEDVVSPLPTRWNSDDKDHTVEVFGDGYEVKYTGSKGSEHEAGAIRADNPMPTQCGVYYFEIMVLNKKREENIIAIGFETRKASLSRFPGWEGESWAYHGNDGKIFASGSNSGRSYGPMYGAGDTVGCLVNFRTNQVLFTKNGDELGIAFKDPIFKDTTKNFYPAVGLKRPGDHIWVNFGQVPFQFDIDGYMKKQQKMVADKIRSTDTANLAPPLNDTELIQQLVLQFLQHDGYVGTARAFAEEIHMEKQALNMDADVPVEGVNIKDDEDANNRQQIRRAILEGDIDQALSYTNQFYPKVLEENGQVYFRLRCRKFIEMIRREAEMNRSLQEAGVKAKSTSQARPHPGNDTQRTYNQHPGGGEDEMMTEGEEEMMDTGEDGTEEYSQRTGNPEDETMAMSAAGVSELCQDALEYGQELLDEFKNDPSHEVTKHLREIFALMAYPNPLEVKEVAHLLDRKGRVAVAEELNSAILTSLGKSSRAALENLYAQTTVLLEDLRKDGGDGAFVTIQSVFDEIPKAQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKZ0</accession>
    <name>A0AAE0JKZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_419724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684172.1">
        <property type="nucleotide sequence ID" value="XM_062824231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKZ0"/>
    <dbReference type="GeneID" id="87861385"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3350877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="594" mass="65788" checksum="A0CD6AB69F787F36" modified="2024-05-29" version="1">MHYPEPPQGGMFSTPVDMGISPEYYPPRSQEYTTSMAYDPNTTLYADAPYNMYHAKSPSLYPEDSNLSVDSRSASSSNAGSPLSNPGNLASWGAPSGPGVSPGIVDQGEYYHGNEYSFTPLDGYNPNFEFSNPKGPGFVDPSLIHPEVRSMAMPSYEQMYPAPSSAYPGSPALSASPQLRTGSTSPFLQNNNYPTYSPFPAPLEPQRRQSLVSYQSNFSEQPYSGDEASKEKQRCPHPECGKTFKDLKAHMLTHQTERPEKCPIATCEYHVKGFARKYDKNRHTLTHYKGTMVCGFCPGSGSAAEKSFNRADVFKRHLTAVHGVEQTPPNSRKKTGGVNGGSSSNKKLTGYAPDATGKCSTCSQTFSNAQDFYEHLDDCVLRIVQQEDPAEAINAKRLAEVENDREVHNTLEKNNLPTTTTMTTQMDDVDEDEDMADEDDNEDSVAGRGSKNSPSRKTKGNPANGVQKSRGLTHSRGGVALQSKTRGRKNRRDYPSSWGFDKGQMTMKKRVVAVFDGPRRLAKDDMMLSTEHEVRIKLQDGKSYVTDLDVQTLRRTEGFLNATEEEKGPWISDDPTEEEKEEARRLLMLQSCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKZ9</accession>
    <name>A0AAE0JKZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_124817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684839.1">
        <property type="nucleotide sequence ID" value="XM_062820727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKZ9"/>
    <dbReference type="GeneID" id="87857881"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000255">
        <property type="entry name" value="Alpha/beta hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="312" mass="34550" checksum="7D89396EEF7ADA3E" modified="2024-05-29" version="1">MAVEKESTFEVAGASLYAKSWEPEGPIKAKLIFIHGFSDHINRYYGFFPSLAARGIAVYGFDQRGWGRSVKKPADRGLTGPTSRVLADIVAFIEPHLSDAPGAPPVFVMGHSMGGGQVLTLACDEQYQDRIVSRVRGWLLESPFIGFAPELKPSFIMVYGGRLAARLFPHRQMVNQIPPGDLSRDPEVQQSIAADELMHNTGTLEGLSGMLDRTDGLTRGTIRPPGGENTKIKAIWFGHGSGDKATDYNASKRYYDRVIAGTVKDRMFKRYEGWYHQLHADGPCSEDFYKDVGDWILERSEGSDSGKFEAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLJ4</accession>
    <name>A0AAE0JLJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_419806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685179.1">
        <property type="nucleotide sequence ID" value="XM_062824237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLJ4"/>
    <dbReference type="GeneID" id="87861391"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8458" checksum="A29DE3A77105C4A6" modified="2024-05-29" version="1" fragment="single">EKLEVQVMETRKAKLGADHPDTLTSMANLTFTWNSQGRHEDALALIQDCVKARQRILGPKHPKTPSSLATVSEWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM64</accession>
    <name>A0AAE0JM64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_513138</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062828630.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87865784"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22474">
        <property type="entry name" value="KH-I_PRP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="590"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="795"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="950"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="965"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="995"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    <evidence type="ECO:0000256" key="8">
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        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3354151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1192" mass="131208" checksum="60C493E3576EBB35" modified="2024-05-29" version="1">MARLRDSRSPSPAGSLSARKRKDDDRRDRDRRDGPVDHRRRSRSPIDRRYRDRDRDRGRDGRDRDSYRRRDRSIDRRDDDYYRGSRRDGDRRRSRDRGPDRLRSPDRRRDRSRDLDREYRPRRDDSRDRARARREGTAESSSHRRDDVRARDQPKPGSTTVKENEPAKSTPTQPQTEAEKKAERLRKLQAMKQKHALKEAKEADVTAGLTRKLFLEMDQRASGAVVGSGANSPAPASPAAAESPATPAPYVGKFDPKAIARNAKPARASSPVRLGDVKLGDVKVGAAAVAASTAVQGKVAASGKAGLLQTGRPISTFGFNKATDALKSTTKRKIDMGDEEIIKRKLVKLPDLALENADDTPYADDDVAEDAEKDFDVLLAGTEEDRAEAQRLLRERREEQIQKESIAMEIDSVPPSVEATTEPVAQNPTAMDVDDEVDPLDAFMAGLEQTASGEEVQSKVDTRTEKKGNTPPEAYFSDDDYGYEADGTDPTSILAMASKKKKKDIPTIDYSKLDLNPIRKNFWVEPYELSQMSEEELAELRLELDGIKVSGKNIPKPVQKWSQCGLTRPILDTIESLGYEKPTPIQMQALPVIMSGRDVIGVAKTGSGKTMAFALPMLRHVKDQDPVTGDDGAIALIMTPTRELCTQIYSDLQPFAKALKLRVVAAYGGNAIKDQIAELKRGAEIIVATPGRLIDLLAANGGRVTNLKRATYLVLDEADRMFDMGFEPQVMKIFNNVRPDRQTILFSATMPRIIDALTKKVLRDPVEITVGGRSVVAPEITQIVEVMDEGKKFNRLLELLGELYADDDDVRSLIFVERQEKADDLLRELLRRGYGCMSIHGGKDQEDRNSTISDFKKGVCPILIATSIAARGLDVKQLKLVINYDAPNHLEDYVHRAGRTGRAGNTGTAVTFITEEQENCASGIAKALEQSGQPVPDRLNEMRKAWKEKVKAGKAKDASGFGGKGLEKLDKDREAARMRERKTHKAEGEEDDVKEDAPAEDGEKKDKTKVAIQSAVSAIVSRDASKAETEDKHAIPAGAVKAGHHASSGKSGGALDKAASAISEINARLARAGQLRPGQPIDNKGPDAGAFHATLEINDFPQKARWAVTNRTNVAKILEATGTSITTKGNYYPPGKEPGPGQEPKLYILIEGDTEVVVGNALSELTRLLREGTMAAADAESRAPASGRYTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM94</accession>
    <name>A0AAE0JM94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_137360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062820894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM94"/>
    <dbReference type="GeneID" id="87858048"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="145" mass="16173" checksum="A8AA535983967C52" modified="2024-05-29" version="1">MAKEQPSNAGCPLQNCDFKNTNGNWTFCQCGSPNTTGWCGGMLPSPRWERNALTNEWQYIQTCDHMCCRNCPREAPAPGSAPESSRKKRKDSSKRGTRGPKDGVSMTAEEAGQPTSYDIALDYSGKEKKHNKDKELSSKSRSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMU4</accession>
    <name>A0AAE0JMU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_584292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3354496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062830892.1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAK3354496.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
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    <name>A0AAE0JMU6_9PEZI</name>
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            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="ORF">B0H65DRAFT_413710</name>
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        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823860.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87861014"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:histone methyltransferase activity"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
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        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="595"/>
            <end position="814"/>
        </location>
    </feature>
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            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
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        <location>
            <begin position="986"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="181"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN45</accession>
    <name>A0AAE0JN45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_19732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686019.1">
        <property type="nucleotide sequence ID" value="XM_062821738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN45"/>
    <dbReference type="GeneID" id="87858892"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="143" mass="15996" checksum="7FDDFC5717C80084" modified="2024-05-29" version="1">MITETNINTIASALQQTVNIYSSSTQTRKAFVLHQVDSIFNINITKTPTNTNAAKQFPPLDVKGTVLDKPAPKQKASTAASKNKEAPHLPRRQPERQVPDGRVEPVAPREQRWLGFSRFFPWLSRNGNGSAGWKRKRRTTTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN75</accession>
    <name>A0AAE0JN75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inhibitor of apoptosis-promoting Bax1-domain-containing protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685781.1">
        <property type="nucleotide sequence ID" value="XM_062828639.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87865793"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="287" mass="31633" checksum="443E4B38950C9FFA" modified="2024-05-29" version="1">MSGTKYTPAPQEDPDVHLDYAQPPPSYQATAESSTANAVLGDQARLFSGAPRSSQDNDHDIPDDFKFGGSVAEATVEIRHQFIRKVYTILTVQLIATGAVSALSFLSDGYKNWIQSHPAMIWVSFAGALVFMLLTFWKRQSYPTNLLFLSGFTLMEAYSISVCVSFFDSATVMLAVVITAGIFVFLTAFACQTKYDFTSWMPYLGGALWGLILTGFVYAFLPHTSTSELVYGGIAALVFSGYILVDTQLVMRKYHVEEEIAAAISLYLDILNLFLAILRILNSQSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPW6</accession>
    <name>A0AAE0JPW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_50721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686905.1">
        <property type="nucleotide sequence ID" value="XM_062828121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPW6"/>
    <dbReference type="GeneID" id="87865275"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="67" mass="7504" checksum="F4B3E60FB454DC8D" modified="2024-05-29" version="1">MRVRPITGLAWETLAPRVFASHSKSLPRYELMVVYELMALTRGFPPSQTVDFVDLTSIPSVPCSCYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ35</accession>
    <name>A0AAE0JQ35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_536284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687040.1">
        <property type="nucleotide sequence ID" value="XM_062829040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ35"/>
    <dbReference type="GeneID" id="87866194"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="535" mass="58062" checksum="235B3E0EB98DE62F" modified="2024-05-29" version="1">MAFLQRSLFSASRNTAIVRSRFQTKSLPLVLHSYSRLASTMAPKLKDPSLFKKDVCYVNGEWVKAQSGKTFEVNDPATGKLIGTCPEFDAQDTKKAIDAAEVAFETFRHKTGRERSKLLRKWYDLMVENHDDLTTLITWENGKPVADAKGEVTYAANFFEWFSEEAPRIYGDTIPSSVPGNRVWTIKEPVGVCGLITPWNFPAAMITRKVGPALAVGCTVVCKAPGETPFTSLAIAELAHRAGIPPGVVNVITALENTPEVGSTLTTDPVVRKISFTGSTPVGKLLMKQCSGTLKKLSLELGGNAPFIVFDDADVDAAVTGAIASKFRSSGQTCVCANRIYVQRGIYDEFASKFAEHVKNNFRVGNGFEEGVTHGPLIHHRAIDKVEQHVRDAEKKGAKVVVGGHKLEKLGPNFYEPTVITGMTRDMAMASEETFGPVAGLFAFDTEDEVVKLANSTQVGLAGYFFSRDIQRCHRVAEHLEVGMVGINTGLISDPASPFGGVKESGFGREGSLYGIGEYQVTKMVTIGGIGPLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ61</accession>
    <name>A0AAE0JQ61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_53941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687014.1">
        <property type="nucleotide sequence ID" value="XM_062829117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ61"/>
    <dbReference type="GeneID" id="87866271"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="518" mass="59148" checksum="20E049889DCCAAC8" modified="2024-05-29" version="1">MAELMGFIIPNLDFLWSTKSWFYFHIVIWLHRYVRLLVHCVSHWTYKSVQPKKDPKFTSADVTVVIPTIHNQFEELRTSLESILACKPAKLILVTTWNKYEALEAMAATLRKPACDHPIKIEVLHVDKANKRLQVCKALEDNHVETKITVMADDDVEWPSTLMPWLLAPFEDDKIGGVGTCQRVKRIDGDLTTRIYNWLGAAYIERRNFEISATHNIDGGTSCMSGRTGAYRSDILKGYPFLSGFKSEKWGKYILNADDDNYVTRWLVAHQWKTWIQYDPECEIETTLETSVKFLYQCSRWARSNWRSNWTSLVHERYVLTQQPWCTYALHIATFTSLAFVVDPLLLFSCWRATEGWDVNDRYTLLAAEIIFMFGFTKVVKLVGLFRKNPQDLIYLPVSILFGYFHGLIKLYALFTLKHTSWGSRADGDEHNTFRLQEKPPRSQTMLTPSGPGLDHLSEKPSKGSRKTGGVTQSRRLTTTGTSVSHNNCEHANGGCTVAPTDLSHSSLQDGGTWSGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRM6</accession>
    <name>A0AAE0JRM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_545359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687525.1">
        <property type="nucleotide sequence ID" value="XM_062829368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRM6"/>
    <dbReference type="GeneID" id="87866522"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3356148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="567" mass="62395" checksum="5C70DA845AF1F479" modified="2024-05-29" version="1">MSLNRVSSLETFAPLLTENRSRRSSDASTRARKISFNPLPPSWDPPALEQIQAVGAFEVPRWKRTLQVVVAVIYCLFAAGIVFGYAAIKPVLKREGAYQDVCRVDPNDEDAISEDTCVEIHLNLMFTTAAVATNVAALPVGAILDRYGPRVCSLLGAFFLAIGALFMSFENKLPFDGLLFGYLFLALGGPFTYISSFQLSNAFPKNSGLILALLTGAFDASSALFLIYRVIYEQTNETFGHQSFFLAYLVVPAAIVVIQFVLMPAQSYKTVGELVEEIEEPITADLEPYDQIDEETALLHEEERQHRAEVVSGIQELLGTTKADKQARKEERKNEISGVWGVMHAYTAWEQIKSPWFILICLFTVVQMTRINYFVATIRVQYAALLSSPALAERVNDFFDLALPLGGILSIPFIGAILDRTSTLTVLTTLVATATTIGILGIITHSMLAAYANVCLFVLYRPFYYTAVSDYSAKVFGFRTFGTVYGTIICFAGLLNFSQSGLDYLLHETFNGDPVPVNVGLMAAGLVIGVVMVMFVGVKARGIKRKLLEEEARGAFGGSHGTREWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRV5</accession>
    <name>A0AAE0JRV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_453242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687217.1">
        <property type="nucleotide sequence ID" value="XM_062826138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRV5"/>
    <dbReference type="GeneID" id="87863292"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="124" mass="12419" checksum="535B5F7A4D7A05F2" modified="2024-05-29" version="1">MATNSAAGNGAIQSPSFSPTANPTFASQGQGQKSSSSTNQEEAPLPSDIKAQILGNNPNHTTTSDASTSSKGGAQEGGKGASEHAPGSSTQEQGVAAEEEGWSEEVKDLERRMGDGQGGSGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MIV4</accession>
    <name>A0AAE0MIV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_512988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000015">
        <property type="protein sequence ID" value="KAK3334261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676427.1">
        <property type="nucleotide sequence ID" value="XM_062828625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MIV4"/>
    <dbReference type="GeneID" id="87865779"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="43"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="898"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="921"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="934"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3334261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1074" mass="120218" checksum="9E522A2D2758481B" modified="2024-05-29" version="1">MSGSSAMTNGGGASFMDVDSQPPGGSKFTDLPDEIQHITADIMPLSLLLTRLSQWTHTKLQDEIAYLASKPLPQAVLNGNTNHQSADNHDTSQESLEKKVHLLNFLQDMHSKWVKTLVITEWSKKAAQVGALIDIRVHMLTKQAHYQELFWELIRMKQDLHWAKVPGPDLKTALEVLTTGQASWMPEEKEAFIDNINTMLSVRLTFDEHEKIPAAFRDYNISNGRVTFKVKGEFEVDLTIGDEDFEQQFWFIDFRFLFTPAPAELSHGVRTFLENKVNTILGDQGLAGCYNYLHEFKIVEFRRQATELAMGRWVDTLKVEKLNRAMSIQYWLKPPHGLEGPSSQTAKSWVLLGVWSGKGVEGDLDSKPSSYISLRWFRDNKETISAEKLLTAVIASHVEYILTSISSKLLSKPRFAQKHARLDLEISKEEPQNSSLAVQLFDNDKAVIKIEPLTGFFTLFPRSPVFLKGQMKLNTSSNAAEEGANLMEQLRFDHTVKDLNSRVRSIGWISEAFKAVWLRKANWMTRQWFVMMSMILGGDQWWLVDLSPPSLTSPAGRLRLFTKMPMTSNQLTLSDTFFRNLSVYAAGMISHITDLRKLHTLKNHTGTRVRLPTIYVRLSECFNKRPGSSSRTLTWAKARTHHLQESGLTQVTQEGPADATQPLRNKFKSLRGNVDHDVVYNHRTGQFSLKLRADMGTPVVDFARRSRTGPGTLDGVVVEAIRLAVLRSARVVFTYSNDPAEPVSGPSQGPRAWSVHLDLPKDAKICCKKWPSPTKTELLTVYLPFSLPLIAAKNAGNVAIVVKAAEWVTIRFSLSAPTTRRLLCLDIRTMGRKGRLLWHGHERPLNAPQDEFDTSLQRSVWHAHGDGRKSFGTSAAADPKIGIETLLCESVKSLVGTLPPPPITAPHQGGAQTPQELGMPPQRPKQQPPPPSQPQQQHRPVNQPQAQPQPQAQPHTQQAQLQAQRQAQARANNNRFVNRAHPGQPPQQRQPGPQTQAQQQQQQQQRYQIQQQAQAMQRMQQQQQQQAAQQHAQQQGQAQQGQRPVHGQGGPQGPGQGGAGGGMGGKNAPVVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJH4</accession>
    <name>A0AAE0MJH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding module family 50 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_561616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676641.1">
        <property type="nucleotide sequence ID" value="XM_062830178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJH4"/>
    <dbReference type="GeneID" id="87867332"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41846" checksum="2CA3D6D6387EC041" modified="2024-05-29" version="1">MSGAQVVDHGGLEESASASSSSSDNCSTPSRLSTTTSTPPPTPPTSPLNLPYHIPSFSPTTDLSRIISYDKPTSQHTHFAQPTLQSLYTTTATNHRVAMGRWKDLDTDAERLPENMTRIGYDADTQVYTYRDNTDGTIWEGAPGATYGKLFPVKPPTPLPSVEVPEIDGTEPGYVLEEGPDHDPFGDHNAVREGDEKPKRGYSTRKRVDSVMDRIANVREKPDRRPSRRESRRERGDAGYGDEKGLERKITKKERDGHRYSEKETVSRSSTTRTTRTGSVPSWDPRPSPPQQEGSSKLKRAGTLSRLSRFLTGKRKEDDPDYDVTPGTGSGSSGWNANGARPRTQPQTDWNRTPQPGTRRRQRATTFDDILAGIPGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJW6</accession>
    <name>A0AAE0MJW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_437300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676564.1">
        <property type="nucleotide sequence ID" value="XM_062825301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJW6"/>
    <dbReference type="GeneID" id="87862455"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="330" mass="34775" checksum="FBC35153E44D9BC5" modified="2024-05-29" version="1">MSAQQPTDRPQPPKSEGCRQGQNPASKHTTPAHSQPSSKIGTPLNSAPGTPGSLSSLSSLSGYPVPPGGPLRMPSENAVSDTPLTSDPYGTPAGGGAQDYMSYRRPTNAQSQLPTAEVRNNLNAARSAAVGASGAGAWGSSRGIIGGSGPANPREARETQYVSVSRNNSSTGLNGMAGGQNYNGRGGHPLRENMQSEARTEGEQMATYGEGEVADAVEGQARKRNEGRNRRESTAQGGRPNLSLAQMGEGQEESDHHGRDRIGSASHREVSGERHGRVRGEVSLEPSEADLERKKLQQSWKREEIKRARKAGKDVDGTSGLGGRQPRPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MK96</accession>
    <name>A0AAE0MK96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable beta-glucosidase btgE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_332834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676969.1">
        <property type="nucleotide sequence ID" value="XM_062823527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MK96"/>
    <dbReference type="GeneID" id="87860681"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3334803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="627" mass="64113" checksum="7577F22409474B82" modified="2024-05-29" version="1">MKGTLVAATAAILAGGASAHRNHHRHLHQPLFEKRVHNESEICVPGCTTIWTTITGPAGLYTPPATAAPATSSAITTSEALPTLSSSMGFANTSSIAVPSTTEVVVVPTTTSMGPVTVPTPIQQTCATPGTYTFPATTVVLTETKTVCGASSTVVPSGTHTLGGVTTVVETATTVVCPYATTKTAENGVVTSVVEMTTYVCPSAGTYTIAPITTTVTDSTPVTVVVPVVETYCPGIYSAPAVVTTVTETNVVVYCPFTSVGDSPVASSTQAPEPTTSVAAPVVSVAPPVVSVAPPVVSVAPPVVSVAPPVVSVAPQEPSSTSSALPVVSVVSSVSQEPSSTVASSSAAPAPTAPTGNLGGKGDKWAMTYTPFTQDGQCKSAADVMTDVKSIASAGFTTLRVYSTDCDTLPSVGAAAEATGLRLILGIFIGTVGCDNGSPDVADQIAAIKSWGRFDMVDLVVVGNEALFNGFCTVGQLKDLIYHVKSELGSAGYSGPYTTTDVVSAWQSMDVTDICNAIDVVACNAHAYFNANTAPEQAGTFVAGQLDIVEKICNKPGFVMETGWPTAGECIGKACPGFEQQATALAAIKQEMGKKVVFFSFSDDHWKQPGSCNCEQHWGCGQVFGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNA0</accession>
    <name>A0AAE0MNA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_432596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678213.1">
        <property type="nucleotide sequence ID" value="XM_062825015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNA0"/>
    <dbReference type="GeneID" id="87862169"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54586" checksum="8CCC8A90F0D66D64" modified="2024-05-29" version="1">MNQQTPPQSTSPSTHSSPAMALTSPDLVLCHTFYMTKDTVSFDRDADTLILVRGTSPGVVIPPQRLFLIRSDHLFLNSSFYKRLFSERCIKNIPRTDDHLRLFKITLSSVDPEALFLILRACHNGWVSLPASTLNVLDLVLRIAKTAHDLEFNIGMADPSSTTASLSWAARGWLLDRRNGLFANNLVDRWKLVKAAFYFGQRSAFRRLSVDLTKRLPDPFWAHLAGDIRRGVNMHFEHLLTSEEKTIIIAIRLLFLFYNILHREAPFPPNMAPLLPTSALPARITQSWSDHTKAMWDAQVQESSVCTCSWLPSYYTVWTRGLELHVDLFAEGFTEHESHESHGMLFRSIAWALGHDVVAKPWDKCEVGEEPKCGLANGREGHEEKARELIGKLRRCLCGWMVDVERNPVEDEDSVEGSDKDSDEDSDLERSGVPYSRVPYYDVEVPGAQYPDPVYQLPLENLNFDAPDFEDRDIEDFQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNK0</accession>
    <name>A0AAE0MNK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_295040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678617.1">
        <property type="nucleotide sequence ID" value="XM_062823063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNK0"/>
    <dbReference type="GeneID" id="87860217"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3339257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="844" mass="93262" checksum="1FC95A3C84D636F1" modified="2024-05-29" version="1">MVNFTIDEIRALMDKPTNVRNMSVIAHVDHGKSTLTDSLLAKAGIISSGKAGEARATDTRADEQERGITIKSTAISLYGTLPDEEDIKDIVGQKTDGKDFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTVEGVCVQTETVLRQALGERIKPVVIINKVDRALLELQVSKEDLYQSFSRTIESVNVIISTYFDKTLGDVQVYPDRGTVAFGSGLHGWAFTIRQFATRYAKKFGVDRNKMMERLWGDNYFNPKTKKWTKNGTYEGKELERAFNQFILDPIFKIFSAVMNFKKDEVAALLEKLNLKLATDDKEKEGKQLLKAVMKAFLPAADCLLEMMILHLPSPVTAQAYRAETLYEGPQDDEAAMAIKTCDPKGPLMLYVSKMVPTSDKGRFYAFGRVFAGTVRSGLKVRIQGPNYTPGKKEDLFIKAIQRTVLMMGGKVEPIDDMPAGNIVGLVGIDQFLLKSGTLTTSETAHNMKVMKFSVSPVVQRSVQVKNAQDLPKLVEGLKRLSKSDPCVLTFSNESGEHVVAGAGELHLEICLNDLENDHAGVPLTISDPVVQYRETVAGKSSMTALSKSPNKHNRLYMVAEPLEEDLCLAIEAGKITPRDDFKARARILADDFGWDVTDARKIWAFGPDTNGANLLVDQTKAVQYLNEIKDSVVSGFQWATREGPIGEEPMRSIRFNILDVTLHADAIHRGGGQIIPTARRVLYAATLLAEPSLLEPVFLVEIQVPEQAMGGVYGVLTRRRGHVFGEEQRPGTPLFTIKAYLPVMESFGFNGDLRAATSGQAFPQSVFDHWERLPGGSPLDSTSKVGQIVQEMRKRKGLKVEVPGYENYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNS1</accession>
    <name>A0AAE0MNS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbon catabolite repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_323437</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in carbon catabolite repression. Represses the transcription of a number of genes by binding to a GC-rich region in their promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677899.1">
        <property type="nucleotide sequence ID" value="XM_062823441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNS1"/>
    <dbReference type="GeneID" id="87860595"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="93"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="262"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3338448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="424" mass="46123" checksum="CBA0508738AA24A6" modified="2024-05-29" version="1">MQRVQSAVDFSNLLNPSESTAEKRDHSGSPRQQAAQPQQPQPEADMATVGLLRPNGPLPGAQPTEPANELPRPYKCPLCDKAFHRLEHQTRHIRTHTGEKPHACQFPGCSKKFSRSDELTRHSRIHSNPNSRRGNKGQQQQQHPLVHSHGLQPDMMPPPGPKAIRSAPPSSMSSPNVSPPHHSYSPYNFAPSGLNPYSHSRSSAGSQSGPDISLLARAAGQVERDGAGHHQFQPRFQFYGNTLHAAAASRNQLPGLQAYHMSRSHSHEDHDDHYGQSYRHAKRSRPNSPNSTAPSSPTFSHDSLSPTPDHTPLATPAHSPRLRPHPGLELPPFRNLSLGQQHTTPALAPLEPALDGQFSLTQTPPAASRSSGMSLTDIISRPDGTQRKLPVPKVAVQDLLGPADGFIRSSSSTSLSGAEMMDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNU5</accession>
    <name>A0AAE0MNU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_551809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678426.1">
        <property type="nucleotide sequence ID" value="XM_062829845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNU5"/>
    <dbReference type="GeneID" id="87866999"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3339066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="691" mass="78721" checksum="B4300305AA1EB43D" modified="2024-05-29" version="1">MSSQEVNNKNTTKRHEVSLWHEIKDHVHASTAPLKKAGAPIANAAVPFARCYVCLDELDIKGIPPVGPAAETRAGCFIPCGHFFCVMCWKVWVRSLKEPVKCYIGPTNPIPVNGIQDNLKLTTMDLSECYRYGQSKPYREFACPICKTDLHHSGCCCEIRPVMIPTNKPKDRLANLLALPRTFLEVLRDTRATVNDNDTAEDNEENTDDEQDALDDEQDAPDDEHDRGDDKQGKPDDKQGVPDEEHVTTNEEADVIIEGYRQKLTPAYNNHRVRRFPNYSDLIQQESGGSTVILPARPLVYDIQTIPQPGFYPVMRLRAQYPNIQDPNGWNCRVTGGRLDKVVDPVCGQCIHDLTRYRFLQHKYDEAEPYWPGYDAHCSTLSAHLDGGGLRQFSGLSWKHAVTSVYLKADNNDWTTKPTWGRWPIELDFMLKARGWTKGVDFVDWKKGCSELEGDWVPKPSFNGLRSRFELEGMGYYPDWDELLEQPYWRARGITKIPRNHWSDHHALGRWVPGFGTVILKTAKFSYTARYTPKEARQSLGELDVKGKLAVTAVYLSAGQDANGHWITKPTWGRWPKELHYMLKTRNWTRGVEFVDCKKASSGLSLSDMEGMGDYPDWDERLEQPEWQARGISKIPRDHWGYGPRHVMGRWVQGHGEVIFQTDRFSYCALYRPVEATTEGTGQTGNSSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP18</accession>
    <name>A0AAE0MP18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell division control protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_251267</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679112.1">
        <property type="nucleotide sequence ID" value="XM_062822463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP18"/>
    <dbReference type="SMR" id="A0AAE0MP18"/>
    <dbReference type="GeneID" id="87859617"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3340170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="196" mass="21804" checksum="A02FEBBE51D33834" modified="2024-05-29" version="1">MVTGTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLICFSVASPASFENVSQKWAPEVNHHCPGVPFLIVGTQKDLRSDKELRDKLAQRKQSMIEFKQGEKLAQDLDAVKYVECSALTQEGLKNVFDEAIVAALEPPQKKTSKRDKKCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP42</accession>
    <name>A0AAE0MP42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase regulation protein NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_298032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678726.1">
        <property type="nucleotide sequence ID" value="XM_062823115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP42"/>
    <dbReference type="GeneID" id="87860269"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3339366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="673" mass="74952" checksum="1BC12ADC4D6BBF14" modified="2024-05-29" version="1">MAIVADKVRRLDVHIDRILGLEPGSIPDAEQDQQETGLLTAVSEPPSPRADELLRIARTLSTASRSGTFLPPSRIKQLLEDSGLATETELAEQGEVGVESQYERDIEWLLVAKATVQTYGILMSNFFDEIMPLSDDIWYWDDVLSSYPKSCLYATQIAPARAWSRAKEVYDVACERIRNIHLQQQSEGVEAAQTGESLSEGVSQKWSQFYSIVRQSMAETSVSNLRRKILSPVDLARAEARRKRAELQKLRETIAAGLGILVDEGLAFDSNAEEDKGLESRLMAADSTLADSIALMDAILTNSAETNEPLSVFEDSVFAYARDVRGAFSTTDSSKPKPSSVAERLIQILDHSLVQHNTAVAKHVSENGRPSPVVRYWLPALALLVSSPTILYVLVKRRDSIIDWIQNLGVTVRDFWFNWVIDPIRKVIGTIRHDENSEIAIMSRDSLKADRESLERMVVEFTLDNPSVAVGSPNVTDLQIADIRAKVREGDVTPVLKAYEKGLRRPFVGAVSGDLVRSLLIQVQKTKVDLEVAISGIDSLLKSQELLFGFVGLAPGVVVSIGIVQYLRTVFGSRKGLRRGEKVRRVVRVLRKMDRILAAGATNPKGELNYKDRGLLLCEAHVLRELATEVLPGDVKREFLEDLEDLTSVKNLVLQEKALQRIRWAYAEWLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPG8</accession>
    <name>A0AAE0MPG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_591606</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678679.1">
        <property type="nucleotide sequence ID" value="XM_062831104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPG8"/>
    <dbReference type="GeneID" id="87868258"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="60"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3339319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="316" mass="33325" checksum="D226B97393F1DB70" modified="2024-05-29" version="1">MNSAVPSTEPQGTPSPSDGLLDFPASSALKLEPHLPPPPPSPAATTTTDTTKSKTSSTKPFVTLTFATSLDSSLSLAPGVRTTLSGPQSKAMTHFLRSRHAAILVGVGTAVADDPGLNCKILSPFSSSQREQHPNQPRPIILDPSARWEVSEKSKVIQLARLKQGLGPFIFTARRVEEVPEERRGVVEGMGGKYVHVEGLKVKGDGEGEGETGSGESFAWADVLRTIKEEGLDSVMIEGGGSVINSLLALEQGGEQELVDSVIVTIAPTWLGAGGVLVCPPRAVGRDGQPAPPVRLRDVSWHPLGEDVVLCGKILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ66</accession>
    <name>A0AAE0MQ66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_468269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680238.1">
        <property type="nucleotide sequence ID" value="XM_062826951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ66"/>
    <dbReference type="GeneID" id="87864105"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="495" mass="55335" checksum="82E7E21FB0596839" modified="2024-05-29" version="1">MATRIPLSLRGASQRSSHLFVTANRLTLTRAFTTTSLLAKSKFPPQSKASRLSRPSTTAQPIPEVTPEPAYDYSLHRQYYDNPTPEPKSEEPPKSNSEPQDLGTLLQQRRWPLLFSGLTALIMGAYISMLIASLSRGPDACSHVHPVTGQLPVTGRPRELDSLTSNPIINDRILREKAMAFDNGLNLPERMAGIRLLRKWLGTRVKGHVLEVAVGTGRNLQFYDWTDVVKGPVTGRELTEEEREEEENKAKERIRSVLDKGGKDGEKRDKDWVEKMKLPGSLEGEMLTFTGVDISEGMMGVARQRLRENVPDGRKLVPKGAFLASREGSDSRIGEGKRGEEQEVLLTTLEDRIRLVRADAEAKLPEAPAYPARLGDKDEEKKKYDTVVQTFGLCSVSDPLALLQNMAGVVKPDTGRIILLEHGKGWSDWINEKLDAWAPQHFSRYGCWWNRDIEKLVKEAEQKVPGLEVVKIERPGFFQAGTTVLVQLKVKSQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQU2</accession>
    <name>A0AAE0MQU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_550276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680898.1">
        <property type="nucleotide sequence ID" value="XM_062829718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQU2"/>
    <dbReference type="GeneID" id="87866872"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3343105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="267" mass="30239" checksum="45870AEB0BB84512" modified="2024-05-29" version="1">MTLLASESTPVPVVEKSEASSWGWDDKDTGGMNDTLTDVILDTRTVVRFNEHREESNTGLQETGHHVQLTDLPNEVLYEILSHLDICDLFSASKTSHHLRTLSTSPTLHSLRLRRARLLLPLSLTSPSRPSLPDLIRRSIFLTNTALISRKLARKLASIHLARRLAARPSAEQLVERCVLPAECVPPTYTKKGKGVKVPQVAPALVAKKRAVERERVKDGLRGWIGEVWMGRVKEREGRVRREEEERGVGRVWRLRRFWEGVSRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR58</accession>
    <name>A0AAE0MR58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_463934</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681227.1">
        <property type="nucleotide sequence ID" value="XM_062826737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR58"/>
    <dbReference type="GeneID" id="87863891"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="198"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3344614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="453" mass="46737" checksum="A396329D7EDA19B0" modified="2024-05-29" version="1">MISRSALTRGSQLALRRPAAAKTAQRGFAAAASPAASYEPTTIAGVKVASRDDSGPTTRLAVVAKAGTRYEPLPGLTVGLEEFAFKNTNKRTALRIVRESELLGGQLQAYHTREALVLQASFLREDLPYFTELLAEVISETKYTTHEFHELVEDCIHAKQAKLDSAAVALDAAHNVAFHNGLGSPLYPTVDTPTSSYLNENSVAAFANLAFNKANIAVVADGASQAGLEKWVEPFFKGVPATSSGNLNTAASKYFGGEQRVAKNGKNAIVIGFPGAALGASQPETSVLVGLLGGASNIKWSPGFSLLSKATAANPGAEAFATNYAYSDAGLLAIQISGKGAAVGKVAVEAVKGLKAIAAGGVSKEDLTKAIAKAKFNLLSASEVSGTGLVHAGANLLAGGKPLQVAETLKALEGVTAEKLQAAAKKLLEGKASVSAVGDLHVLPYAEDLGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRJ6</accession>
    <name>A0AAE0MRJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_468272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680240.1">
        <property type="nucleotide sequence ID" value="XM_062826953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRJ6"/>
    <dbReference type="GeneID" id="87864107"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="120" mass="13674" checksum="C43CD527F2ED4AB7" modified="2024-05-29" version="1">MAWIPRDGFSYIRRTEIALSSEYPGRSMSSNIATQPTSFSSLFATTTTGFLVIIPRLQRGAARPVKRMKGTKEDGKSLVFSGFPAPFLRYRERADVVIHKREKPERMRSEKKKIICSCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRV7</accession>
    <name>A0AAE0MRV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_425360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682053.1">
        <property type="nucleotide sequence ID" value="XM_062824570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRV7"/>
    <dbReference type="GeneID" id="87861724"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042090857" evidence="14">
        <location>
            <begin position="20"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="150"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="462"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3345440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="523" mass="55274" checksum="918791BED973035D" modified="2024-05-29" version="1">MVGVSKLLELTLLATSARAFFIWPPLPCDPGEPCYVSGSTDVSGKGLVAAGGQFHSPSPPGGEPQMDGFISLSVVQRNADPNESLEAGAARAARDAKRIAYRFATLDSPRVPKKRSKLAARTNTYSVVEPESTKRKDSAGIYHDPSDYAYFAKVQFGSSKKPLYMLLDTGSSTAWIMGATCKSDACIYHDLFGVDDSKTLKLQSKEFRLAYGTGVVQGTLARDSVSVAGISLNMSFGLANETSSDFTHFAFDGILGLDMAVGGTDGFITELVNQKVLQSNIFAVTLGRASDPINEGQITFGAVDSSKYTGDITYTNLANNNKGAWVIPIDGFGFGGKQVTLKDRTTYIDTGTSFAFGPQSDVTALHKLIPGSTTVDQVTWYVPCSDSPIEVTFSGVTYKISAKDWQAGSGTSCRSNIYGREVVANGWLLGDVFLKNVYSVFDVDQKRIGFATKVEPVAATTTSGTQTSQTVAGTISSDGTPTSADATGQSATPSGKDSAGYQLKSNAYALVLGIAVMAAAMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRX9</accession>
    <name>A0AAE0MRX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_465434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681696.1">
        <property type="nucleotide sequence ID" value="XM_062826808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRX9"/>
    <dbReference type="GeneID" id="87863962"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3345083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="85" mass="10121" checksum="C9FF282419B46DAB" modified="2024-05-29" version="1">MSDDERVTKPFKFVTAGVDARFPNVNQTKHCWQNYVDYHKCILAKGEDFAPCRQFWLAYRSLCPSGWYQRWDEQREAGNFPVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRZ0</accession>
    <name>A0AAE0MRZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_208837</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682158.1">
        <property type="nucleotide sequence ID" value="XM_062821903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRZ0"/>
    <dbReference type="GeneID" id="87859057"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042129535" evidence="10">
        <location>
            <begin position="18"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="126"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="12">
        <location>
            <begin position="390"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="13">
        <location>
            <begin position="628"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3345545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="940" mass="101778" checksum="FA5EA0C0CCA55457" modified="2024-05-29" version="1">MRLSSFLLPLLAVGGEALKKYIIEVDQGVDLDDLANKFSVSAGGRSVIRRFDKTSDVFFGLCVETDDMNIDDLPNFPGILRAWPVGRATLHAARAASPVGNIVSDGNYSVHSLTGVDKLHAKGIYGKGAKVAVVDTGIDYKHHAVRSFLSLSAFPEINNGSSVEDSGMDSKSPVAPILLEITVSTKMAMLRKRGYNTTNRGLAWPFPDDDPFDYQGHGTQVAGVIAGKTDWFNGVAPEATLYSYKVFSNDSQVTDEDIIIDAFLQAYKDGADIITSSIGGEGGWSGGAWATIASRLVDRGVLVTISAGNEGYKGPFLASSGSSGKNVIAVASTEPSVAPAWPFKATFTHGGNSTTIQLGYLIDDLFDQPWGQDLTDDLPIIPLSLNVNDTADACEPLPEHTPDLSAGILLIRWGGCDSSVKQENAEKAGAKRVLFYSDDAGPVWWLSVTSNPPAALIEAKTGEAMVATVAAGGKVTAKFAVTNDTTWRVGFYSSAGGIPSGFSSWGGTNELEIKPDVAAPGGNIYTTDINEPWTFQSGTSMACAYVAGIAALYIGEHGGRSVHGPGIAKALANRIISSGAAVPWQVDNPVGNPIDYGFWAPVPQVGTGLVNAAKVLDYTTSLTWEKFHLNDTANFQAHHSVTITNNGPKSATYSFALQPAGAFNAQSDYDPEYLSTFTDYISPYPLVPRVQLPQNVTIAPGHSKTVHIKFQPPSPTSYNATKLPIYSGKVLINSNENEDLSIPYYGAAFSLRFAFKDHMFIYGPFQAAGPDREDIDTYHTYDFNLSLAAQSYPTVAVDLRFPTKTLRWDIFEADWTEAQWNASAPYPPTGDNGYVGSVAFWSYSDLVWRFDPDNRDLPGYWDTISFPLTVGSGLNRGNARDRFSTWFMWFGKLVGGSYIRPGKYRFRFAAQIPFTDPSHSDSWDVWKTPVITILDYDRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS77</accession>
    <name>A0AAE0MS77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_240863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680915.1">
        <property type="nucleotide sequence ID" value="XM_062822319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS77"/>
    <dbReference type="GeneID" id="87859473"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3343122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="281" mass="32551" checksum="4A9E00F33A648540" modified="2024-05-29" version="1">MVERVQLQETVKVPARRLSRYYHYAAIPAIEWFTRLYIEPVLKPPSYGRVSLPRIKFPYCPTPLYYPEFYESVLESARSEWQKNGIKLHPFEVARMIPQDGRIDLAYNLWWRQILDGLRWQTRKPTREGSLQAEAVDTSTDTNTLRQQFMAKEGKEEVRRLSCFLVDFLKHGEFGVWDFSPRILHSPDENTSRYVSYVKHIIVATSYSSFEGHVYGITQPKNKGDLYPFWHPLKDCPNDTFPTSRGTAAWNRVILLEGLKDVATTSTPVDLCSPPGTSART</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSD5</accession>
    <name>A0AAE0MSD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_549222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682146.1">
        <property type="nucleotide sequence ID" value="XM_062829639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSD5"/>
    <dbReference type="GeneID" id="87866793"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="340" mass="38440" checksum="4139C2C92F3BBF61" modified="2024-05-29" version="1">MSDVYGHSRCNITALGTGGNDGCFTPRNPLQISPCRIRVCDDKSTIYAVNSLLENTFVENVEQSPLFKRGWVFQESVLSSRAVYFGAPQLFWECRRQAFAESWPLKTDTPRVQQRLTEPTLRATGDTPFSSKTVFEALCNAEEQQHTFPSFLAWEKIAKTFIGTSLTFTSDRLFAMAGIARTIEHFRSFTYVTGTWRELYPLDLLWRFTRELGERKNIVSGSNAPSRSWAAKELDMQELLKNIAESEKNTQRPAHWDGNKRFLVESVTGVAYLSQLVEFPDPPFESKYRPDKEGEITIVLKGHVRKGLVKTELDVQSYPEEGRLSTGVGTEAAIVSSDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSL4</accession>
    <name>A0AAE0MSL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hsp70 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_467607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682371.1">
        <property type="nucleotide sequence ID" value="XM_062826915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSL4"/>
    <dbReference type="GeneID" id="87864069"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="925"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="968"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1002" mass="108774" checksum="900A8E844C71B426" modified="2024-05-29" version="1">MARVSTLSPLRIFLSAIFLFSAHVFAASAVLGVDLGTEYIKAALVKPGIPLEIVLTKDSRRKETSAVAFKPSSNGPKKGAYPEREYGSDAMAIAPRIPGDVYPNLKAILGLPAGSAEVREYAERHPSLRLEAHKTKGTSAFKSAAFTEEEEAWLVEELLAMELQSVRANAESLAGPSSSVRSVVITVPPFYTIQEKRAVELSAELAGLKVLSLISDGLAVGLNYATSRQFPNVNKGERAEHHLIFDMGAGSTKATVLQMQSRTVKDVGKFNKTIQEVSVLGSGWDRTLGGDALNYLIVDDMIRQFVESPKAQKAGVTLEAVKSHGRTIAKLTKEAERLRHVLSANQNTQASFEGLYDDVDFKYKITRAEFEEMAATHAQRVSVAINNALTMAGLQIKNLDSVILHGGASRTPFVQKELEKVLGGADKIRTNVNSDEAAVFGAGFRAAELSPSFRVKEIKIADIASYPAGMRWKNDEGKPKHQRLWTATSQLGAPAKEVTFNNVQDLSVNFYQLVDGVEVDTTVFTTKNLTASVEALVEKHKCEKADIKFKVGVRLLSENGEVDVTKAAVECEADELEKAGIVDGVKNLFGFGKKDKTEGDEDSTSASTESSTSTSSTTSTSSSASASASAETKPGEPKKKQLVQINVDFTLTPTGPTSLLTKASLQSLKDRLKSFAASDRTRQLREEALNQLEAYTYKISDILDRESFIAHSTASERETLQQKKDEASDWLYGDGADATREEFKAKLKELQNIVDPVLKRAEEAEKRPEILKGLQDALHNTKKFVKDIREKISAYDAFHASASASASASTSIASSSSTTAPASSATGDFDGLEDDASTTATAEDPMKFLEKDLGPVPPLYTLEDLKESEDLYTSISTWLELKVAEQEKLGPTDDPVLTVKDLLERREKLDKAGMALAMKGVKNFEKTQTKGKGGKTNGKAKAGKKNGKATKAGEKPAKETVSDEEIEEILRKVMADEKAKEEAKAQKGEKGSKEEPIKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT56</accession>
    <name>A0AAE0MT56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_158044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682956.1">
        <property type="nucleotide sequence ID" value="XM_062821191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87858345"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="11"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="860"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="928"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1229"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1248"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3347874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1288" mass="137295" checksum="E077280D70E433EF" modified="2024-05-29" version="1">MSGYPDPNASSITVAVRVRPFTIREAAQLVRRDEGTVFLGDGSLAAAPTPKLNQRGIRPVIKVVDDRCLVFDPPEDNPIQKFSRSVVPAMGKKVKDQVFAFDRVFDENTSQVEVYEGTTKGLLDSVLDGYNATVFAYGATGCGKTHTITGTPQSPGIIFLTMQELFEKINERSGEKHTEVTLSYLEIYNETIRDLLVPPGSATNKQGLMLREDSNQGVSVSGLTSHKPKDVQEVMDMIVQGNEYRTVSPTAANAVSSRSHAVLQINVAQKDRNAAVNEPHTMATLSIIDLAGSERASATKNRGERLMEGANINKSLLALGSCINALCDPRKHNHVPYRNSKLTRLLKFSLGGNCKTVMIVCVSPSSEHFDETQNTLRYANRAKNIQTKVTRNVFNVNRHVKDFLVKIDEQMALINELKAQQRDAEKVFFAKFLKQSEKRDAVVREGLARLHAAYEHAEKDRMEVIGFMKKQRAIERRIGLLSSWIAAFDSVCDARGCASEEEMPAPLTAIRKTAIGIMNELETSRNHIHQRLGRCNWERSLDTALQHSISQLPAMGGNSEGCNAERDILAREAELLRTGFMRDAYHEVVEQDKAGDAAVLQTLLMAQFEIMASLEELLRMEERQAVEHAKGMVNRLLETGLQAAGQVVKPDGSLSTAGYRGTGLSVPKLRRKSGAINGAKTIPQPVFTPSAAVGTATSTSTETAMDISTEPEADVEPQMETWDGESIPHLSPVKARKVAYASSKKAGTSFTFTPVKKKPSVRWRDDETEEGTLADFEKTPQKWDSSPGEPENGISPVRPSMPSYLSDMKSPPPPQRDNTDEDVEMDDGTGPALPSIPDLSGLSIGKPNRFQAGFLSKSRTSLAGSTPGSTLTGNGVLQSQPPPVFNLNLANNNNVASQPNGGDEERPAQPLRSIPVSRAANAYSSPVSYSAKAPNAAPSTSNTMNNGNQDGSPKIPPPPTMSSLQQVDENQPPVAMRKSSSRLSLGSAIPRRLSTSPRSASGGSTDSDNSLVIDPLKLRSALQEKKRRDRLSLMSGTAASIAKAKRRASSAAPLSNGASSGNGSASTPGPAASRPSVAKVSHRASVGHGRSSIGGHRASFGGSLHGRASMGAHHRASIGAGGHPGLGGAGRRSSMGVGGGPLASATNGISRHRRGSSLEKSGAAATTRKGGIPLPTITGSPPVRSGTTGLAARRVSLGPNSSWLVETGIMGPKSGSGLTNAQPRRMGINGNGSGFGKGSPNGGEDDNSASGTTTANRLSGFGSFDGKNRRITIGAGPTGKKSSSSLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTF1</accession>
    <name>A0AAE0MTF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_462546</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683241.1">
        <property type="nucleotide sequence ID" value="XM_062826648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTF1"/>
    <dbReference type="GeneID" id="87863802"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="146"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="672"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3348159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="781" mass="86968" checksum="58BD5A4901F5BDBB" modified="2024-05-29" version="1">MSLIPYHPREGREIVLRHRNAIVVRDPLTQRLEIRGLQLHECPTCHQPLRTSSESHVDDDSDRRESYVDPDYFRMLRDGHNGQGPSNPRPPSSPIRRLVRPVPAIDDRGNQVGVHNAEFVSSEPVPPETTRIKKEAFAPNYFETFFHEERTLGRGGKGVVMLVRHEIDGCNLGHFACKRVPVGDDHAWLGKVLVEVELLAKLSHPNLVSYRFSWVEDVKINKFGPKVACAFILQQYCNGGDLQQYVIGDLLKEPTIEEIKAQRRRRSKGFIERPSVTQRQLPFKDIFSLFKDITSGLAYLHAANYIHRDLKPSNCLLHREGGRTSCLISDFGEVQPENAVRMSTGSTGTISYCAPEVLIKDANGKYGNFTAKSDIFSLGMILYFMCFGRLPYANANSLHEELEDIDLLRTEITDWKGFEDERRERPDLPAKLYQLLKRLLSINPAERPSANEVLSAMKNESSLDGVGGNSTGPIPSIGLAGRRIQDLDSPMPPSTPVPGQSPAPSSPDAPSLTTPPQTDHRHAKVSSSSDEDLPLSVDGYTPVFDTHQNGASDHRPHDTRTQSQSLTLSRNGSVVSPHPSPPAITTPLLMPPPSTRLEQMKHRAVLTRYHAGRWLDANGLSSGVLLRLAFLGIKIFSLSWICWPYTSNIGILTSVFALAILDLLNPVGSPEPRRGSNAMLGVSPGSRRGSSNEQLNNHNSQLDDHDGHMVRVTPDTAPAYDNEQYWRTGTMVGWKTSVSLLLLHFAILWVTNHMGLLCAVQAGHGRWSHWPPPDLPHDEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTI9</accession>
    <name>A0AAE0MTI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_159453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682999.1">
        <property type="nucleotide sequence ID" value="XM_062821206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTI9"/>
    <dbReference type="GeneID" id="87858360"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="200" mass="22797" checksum="F55CF2897A77929A" modified="2024-05-29" version="1">MHINRLPLLTRSQSVFGITTLEISVDDWRFPVTLIAVCIPFFMVIFVLQTRWGMRMAKKMGNRIERYTSGLFGRPPSTNSWQTTGDYGRLRERSSTANGNEELGERRGGRKRPTLRDKRTYSGSSSRFSTGSGAKRGGSQHGLLPQHQIREGGSWMVMERMRGFFASMMNTNRWSWLIWWRNKGITEDLAAGDGASVEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU95</accession>
    <name>A0AAE0MU95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_111478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684527.1">
        <property type="nucleotide sequence ID" value="XM_062820583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU95"/>
    <dbReference type="GeneID" id="87857737"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF8">
        <property type="entry name" value="STRESS RESPONSE PROTEIN RDS1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042284188" evidence="1">
        <location>
            <begin position="22"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="324" mass="32798" checksum="65EDB6B161AA3840" modified="2024-05-29" version="1">MPSITKTLGLITAGLAALTSALPAIPKLTDNQLNIHSLMRRQNALAAAAGLTDVDILEFALTLELLEAAFYREGFAKFPAADFTALGLSESQIKDLKNIGSTEEEHVILLQGAIAAAGVKPVQACTYNFAAVNSAAAMVATAAVLENVGLSAYLGAAQLVTDPGILTTAASILTVEARHQTFIRAASGVVAVPQAFDTPLSPKQVFSLAAPFITSCPEGSNLILTAFPTLTMGGDGKTVAAAGSEVKLQSSDTSATAGAKFCAFTTGGIPGGTAFTAFDAATGGCVVPQGLKGVVYVNLASAGPLTGKLTDDIIVAGPIVMQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUL5</accession>
    <name>A0AAE0MUL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_423624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683420.1">
        <property type="nucleotide sequence ID" value="XM_062824471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUL5"/>
    <dbReference type="SMR" id="A0AAE0MUL5"/>
    <dbReference type="GeneID" id="87861625"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3348338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="147" mass="16514" checksum="214C6CE3AFFD154A" modified="2024-05-29" version="1">MALKRINKELADLGRDPPSSCSAGPQGEDLFHWQATIMGPADSPYTGGVFFLNIQFPTDYPFKPPKVSFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRARYEATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUU2</accession>
    <name>A0AAE0MUU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_454569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683660.1">
        <property type="nucleotide sequence ID" value="XM_062826200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUU2"/>
    <dbReference type="GeneID" id="87863354"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="18270" checksum="6AE50245073B7518" modified="2024-05-29" version="1">MASIARCLRIARPSVVSAFAQSSVRIARPFSVTANNELRKYTREHEWIELSDDKKTGYVGISSYAAKALGDVVFVELPEEGKEVQAGDALGAVESVKSAADINAPISCKVIASNLTLEESPSTINKVPEDHSASGGWVAKVQVSEEGIKDLEKLMDEEAYKEFTAAEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVJ8</accession>
    <name>A0AAE0MVJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_144736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685401.1">
        <property type="nucleotide sequence ID" value="XM_062820984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVJ8"/>
    <dbReference type="GeneID" id="87858138"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="513" mass="59065" checksum="964CE2288D7D0FE1" modified="2024-05-29" version="1">MSGQTLIAWLQDCDYNNNICWICGDPGSGKSVLMKHIVSQARSDPSIFEPYTRGAERNKDTDREKPIVIWHCFARAGNPVSMQFEELTMIQNILFQLFKQFPGEIDRAFAYTYNMMLSQRKPDYIKAGLSTLKFKTLENTLFFFLADTGLVRPRVFIFLDGPSGFSRQKSAFFNIDEVEEAPLIHKLKGIRGVKVCVASRPGGVFHDWDRSFHGREERGYKFHTLRIQDYTREDIQKFSSNRLESVLLPLRIPLAASIANASEGSFILAKDGCEAALRAYEQSNDEEAITYSQILFNSLLHEIERMPLTFKLPNYDFVQENRLETLSTYLNFIITHIENNMSQARNQRPLSLLQFTLAVESYRDTLPSGPLTDFQIEFLARACDNIAHKIRKELYPFIVLREMEHEEKPQYVDENLVQNWKGLVRAAGSKVMLLHSNLVLFLENTLAGRHLLDNDDGQRANSLVQHDQLHSHIADEMRAQNPRFLRDRVATLLKASLFEHTSLMPEIINEECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVS8</accession>
    <name>A0AAE0MVS8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_7370</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685671.1">
        <property type="nucleotide sequence ID" value="XM_062831341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVS8"/>
    <dbReference type="GeneID" id="87868495"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="17">
        <location>
            <begin position="98"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3354293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="455" mass="49769" checksum="BF80C70CA0826C64" modified="2024-05-29" version="1">MSISDHPRVYGTVALTAAFAAGILVTLGFKDCYPELENRYQRRRNRNLSRSNGDFGVVVSTANRKHRESLIFGPVRLEDHEEVTSNINSSFDWVEGIEGCIGNTPLVHIRSLSEATGCMILAKAEFLNGAGGSPKDRVALNMIQDAEERGLLVPGRGDTIYEGTAGSTGISLATLARAKGYKCHICMPSDMAIEKSQLLHHLGATVERVNPAPITSPEHFVNLARRRAREHEATHADGSVGFFADQFESPANYQAHVKTTGPEIYRQTDGQLDAFVAGAGTGGTIAGVAKYLKEEKNLWEARVVLADPQGSGLFNKIRHGVMYSSTEREGTRRRQQVDTMVEGIGINRITENFESGRVLIDDAVRVTDEQACRMARWLVEHDGIFCGSSTAVNCVAAVVTAMKLPKGSRVVTLLCDSGNRHLSKFWKKIGDMGLENDTHAPEDLFAELGLEDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVY7</accession>
    <name>A0AAE0MVY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_437616</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685609.1">
        <property type="nucleotide sequence ID" value="XM_062825320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVY7"/>
    <dbReference type="GeneID" id="87862474"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="322"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3354231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="460" mass="47733" checksum="B4D0790C8A12877E" modified="2024-05-29" version="1">MASPPKPWERQGATSGASAPAPAASSAATPSSESNTTTTSGSTPAIPARPASLTASVNQNAANYSRPMGAMGASPYGVGVGSYGTTYGSSYGSAYSSPYSSPYSRYGGMGGYGSSMYGGYGGSMYGGGMYGGGGMYGGGMGGMPGDPNNPESLTNRFNMSTMATFQMLEGVVGAFGGFAQMLESTYMATHSSFFAMVAVAEQFGNLRQTLGSILGIFTIMRWIRTVFAKITGKPLPADATSLTPASFAMFEGRGKGGAAAAAGGAAGAMPKPSRKPLIFFALAAFGLPYVMSRVIKSLASNAEEEEKKRQLVVAQQQTIDPTKLEFCRVLYDFSPAMQGNGEIVPGVDLEVHKGDLVAVLSKSDPLGQPSEWWKCRARDGRVGYLPATFLEVLKKPGQPVAAIAGAPSISIDGDTRANSLSSILSDADDTVGEWVDISLPTVVTQLPSLFSMFGFNCTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW27</accession>
    <name>A0AAE0MW27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_544361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686462.1">
        <property type="nucleotide sequence ID" value="XM_062829286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW27"/>
    <dbReference type="GeneID" id="87866440"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="67" mass="7651" checksum="18FCACA03D7AE044" modified="2024-05-29" version="1">MNSRPNSGYYDRNHRQSAALIRARRPYLFKNVVLGASITAFTLAVYAYTLNVVGQDEFEDVKVPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZU7</accession>
    <name>A0AAE0IZU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_437157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676523.1">
        <property type="nucleotide sequence ID" value="XM_062825290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZU7"/>
    <dbReference type="GeneID" id="87862444"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="221" mass="23880" checksum="43AC913B6B36F852" modified="2024-05-29" version="1">MPPTRPWTTKDGKVHGMDQQIPNPSSHVRFYPGDQIQGNGLDLATVLKKKAAAAAEREKFMKGAGARGPGGWGSSSRGRGAGASSTGSARTFDPAQFGLERDTNIVWIEEPRRRFAKNQQGTDNFAQVQSIIRQSLSRLGLDYAVVRTGPHEDQNLHDELGTVRKRTDAVSGRVSNETSPADLHVTLYAGKKDGMRGEELSNSGSSKTRTLFGSRSRGGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J020</accession>
    <name>A0AAE0J020_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_387340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676643.1">
        <property type="nucleotide sequence ID" value="XM_062823717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J020"/>
    <dbReference type="GeneID" id="87860871"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="78" mass="9349" checksum="3B5E6C7C85769FE8" modified="2024-05-29" version="1" fragment="single">MANTADLSPIWRSLPYDLVQEIINHFTDDVIASCDYGDDHADGQMLDPGFPGRVYRYWQTFRQDRLFKSQRRRLERHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0U9</accession>
    <name>A0AAE0J0U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_335549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677034.1">
        <property type="nucleotide sequence ID" value="XM_062823561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0U9"/>
    <dbReference type="GeneID" id="87860715"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042290910" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="4">
        <location>
            <begin position="181"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="294" mass="29967" checksum="AB8DC9AF8534F1D5" modified="2024-05-29" version="1">MQLSRLLLVGLSALSVAEASYMRIGVNVPHHKNLGALARRADDDSSSADIPIPTVKAPTPETTSTKAAPVTTTSADPPAEPTTTTKPPPVSVPAVTTTSPPPAPTTTKPSNNDQPPVTANPNGDVVSSTQGPAPTPSSSAGGSGGSSNNDDGDSKSYSSVKPVILTVTQVITTTNQEGVATTMTTEALTTSTPPPSLASDKNNGKSGGGMSNQTRNTVIGVVVGIGGAIVLAGCGIVAWRIRSRKRQSDEADNLMEYNDAGKPEVGGSMVGRTPFQSTLESYHAPTHVNQASNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J124</accession>
    <name>A0AAE0J124_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_436475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677055.1">
        <property type="nucleotide sequence ID" value="XM_062825246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J124"/>
    <dbReference type="GeneID" id="87862400"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="671" mass="73558" checksum="2F95C7207141A0A8" modified="2024-05-29" version="1">MNLNSERRVHPRCSSLLRNASYPTTTLTSYTSVDSLLSVSLISVPSDTTSSQDSDDSRSSASDTEQSYRTFFFPTQFSNSSQTSISSVESLCEPSVKHVSHWQKSCTEQAKGDRLLRQNPRRTNRSATSRTGHPPSLVRQDDRKVNFVDTVVDSATLTVEAIWPLSSACPRNGNGANPGLSLRQFIQETLKRSRSSYSTLTVALYYLILIKPHVPACDFTMEQSRDCLENPGLQCGRRMFLAALILASKYLQDRNYSAKAWSKISGLNVKEINQNEMAFLLAVNWKLHIPDHLYERWTECMAKLNPSLPPCSGSAAQQIYQQQCANYKNAIRKLTPELDNVEEVASWFHQRSPVIVPAVARSLYTPPFERSSPFESKVECRARIPAPMATPAVMEPSPFAVQAECRMAPALGLLPSPRPTPQLRAMTSTPAVSAASCLLAKGSSMGYAMQQVSHATAAQLSDRWPSASSPPYLTRRSSLANSVSTASSPESMVSDSSQLSRSSSFSATSVESAPSSDSDAQARYQYGKQEGEKYGLQPVVVSAHETYGGNTLTLSPESCYMDPAGQNLNDYKVAALALQDLRRQGSDFPARAGMKRARAPSTHKPLQDNVRDLLSGMDSVNPSRQMPVRSFSDESYKRLCFSVEDARPAIPSLHPAMGGIGGPGMWDGILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1E6</accession>
    <name>A0AAE0J1E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nitrogen catabolic enzyme regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_512562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677071.1">
        <property type="nucleotide sequence ID" value="XM_062828583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1E6"/>
    <dbReference type="GeneID" id="87865737"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="720"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="775"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="785"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="910"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3334905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1019" mass="107910" checksum="D861C1095FD685FC" modified="2024-05-29" version="1">MAASTTTPTATTRPFFSMNPTTTEHDFRFPRRPGDSVAGTGLGGAAMSSSSANNQHHPMSAFNHHNAANARGRDSFGRPNNNINGFHQRQSSSNNSMNYSSRNTHPTSDYHNQSASSGGPAYDLLRSSAFPPFQDGLAGMTQSPDEMQKQDPLATQVWKYFAKTKLALPNQERMENLTWRMMAKPLQAHRRLMETDRAHRFSETAPRSGIAHLRKSSEQTQSQGSDLMNLDDFINGENMGTPAGMSIAPSPETSSKMADDRAAHHSSAIPIKARKEQQPQHMIPQSVPAALHHPRMQTEFGYLPRHLRKTSIDETSKRNPNRKRPADFSPHVSAVTPSYATNGLDADTDLHDYSLDHTSHGGMRQQTAHSSVPYALDTANLDADTFITSAGPFQQNFSFSPSTSPMVSHDPFTAMFGPNNSSMHTGPIHGNNFYSPPASAFQSTASTPHPMNEGGDNFYFSVDMRQARQQPYRAGNHGMGNTMAHQFPYGGNGNMMFPASSAGPDPTPSFTAPNSFSGHIDPTQVFHNEQPVRSPGINLLQDSLFTFGAESDGDEEDGGAFADRNLSISHDFSSQSMEEPAFNSSSMGWDPSLPGNFSTQAARYPGGPPRKQVTIGATTTDYVDNTGEWDGNGLPRSQSQSFRQNDPRKGKMHRTASTPGLFAKNNPFERLAQSTSNSPPADAGRSSGLSSVPASRPSSPPPGAKQGSTTNLQGAAGNSAETPTTCTNCFTQTTPLWRRNPDGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRGSGASLPVGGTSTRSKKNASMSAAARKNSTLSITSNANNQPAAQVATSPAQQQNRASSVNESPSPASGPASGGNTAGSTPSSYHGSAGSSSGVVSGKNVIPIASAPPKTAPGPGAGSTSRRDTISSKRQRRHSKSAGSDQPVSAGAVSSSGMDVDSPANSTASNETMPTFNPGGAFSGLPPTTQSSLGFGNGYINTPRPMVGPGGMMGMPNGQAGQMMGASSSSGPGSGPSRTGAEWEWLTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7K1</accession>
    <name>A0AAE0J7K1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_478753</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677834.1">
        <property type="nucleotide sequence ID" value="XM_062827497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7K1"/>
    <dbReference type="GeneID" id="87864651"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3338383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="484" mass="53204" checksum="CB32A15F77252BA3" modified="2024-05-29" version="1">MSVPGTSNTRPLTLTEELEKLEQSITLTLQEIDSNFSRAHRIVTTNILPLVEQYGEHSKSVWESTKFWKQFFEASANVSLSGYEELANGNETTVLNSNEESTSAHDQTTPARTPHPQSAGRSHDITIEDESSTFNARGQDQGRQRTTNDSVLTDTGDDLSGSTPRPPATKSIPSRPQFANLDSPYEQLRRRELKAAAEANKTPGFGSGSGGDAMEDDDSELIFRQHTARLPDMSMTPHRAQNTPFGEQQQQQRGGTANKDPILHRMPDRNYRVGATPHKGHQASGVSPIKWKVTEKKPLLDPKGKGKAKEDRPLWQDSFMSSPEMEVPQLRSAAFMSPIRSAYRGNTRAAAAAYAARTAPRTPGLSVQTPMAGRKTKDVFSANAANATNAGKTPIPKGTVEAKKRYLEEIDWESDSEQDPFGGMSPPKTIQFALPPSKLLQTPAREASKKIVENLLLTAGEMPEESEFSPSVVKMNPDLMDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7K8</accession>
    <name>A0AAE0J7K8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_477571</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677491.1">
        <property type="nucleotide sequence ID" value="XM_062827432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7K8"/>
    <dbReference type="GeneID" id="87864586"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="318"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="596"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="815"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="823"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3338040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="857" mass="95954" checksum="5184D3AC2613C478" modified="2024-05-29" version="1">MRLDVKRQLFARSERVKGIDFHPTEPWILTTLYSGHVYIWSYETQQIVKTFELTDVPVRAGRFIARKNWIICGSDDFQIRVYNYNTSEKITSFEAHPDYIRAICVHPTQPFVLTASDDMTIKLWDWEKGWKNVRVFEGNSHYVMSLAINPKDTNTFASACLDRTVKIWSLGSSTPNFQLEAHETKGVNHVDYYPHSDKPYLLTTSDDRTVKVWDYTTKSLIATLEGHTNNVSFACYHPELPIIISGSEDGTIRIWNANTYRFEQSLNYGLERAWCVSYQKGKQGIAVGFDDGSVVIKLGREEPAVSMDGSGKIVWARHNEVVSAVIKGADADIKDNEPITLTTKELGTAEVYPQSLIHSPNGRFAAICGDGEYIVYTALAWRNKAFGQALDFVWASKEYSSTNEFAIRESPTSVKIFKNFENKVGGLDVPFAADGLSGGVLLGVKGQGGISFYDWRTGGLVRRIEVEPKQVYWSESGELVALACEDSTYVLRFSRENYNEAVQAGLVEDDGVEAAFDVVTDISESIRSAEWLGDVLIYTNSTNRLNYLVGDQTYTIAHFDKPMYILGYLQRDGRVYITDKDLNVTSFALSLPVLEYQTLVLREDMETAAELLPSIPEDQLNKIARFLEGQGHKELALEVATDPEHKFDLALSLGQLHIALDIARETDADHKWKTLGDAGLAAWDVPLATECFVKAKDLGSLLLVYSSTSDREGLAKLAEQATEAGAHNVAFSAKWLLGDVEGCIEILKNTNRLSEAVLFSQTYKPSLTPELVAAWKESLEKQKKGRVAKVLGVPGEDSELFPEWDEYLRLEQEGPAAGNLIDIDAEEAQEESPAEEAEEEVAEEQQEEEKEVEAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J806</accession>
    <name>A0AAE0J806_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_308031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="493"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="877" mass="95898" checksum="C33749CD1171633F" modified="2024-05-29" version="1">MPTYLCHGFRWQRRSIRVYTVVQDLDDVSPEWLIRPTSSRCLLQSFYNLFEFLPYCSPYGSGSWDSEESEEDEDGASDEENGEGIGGNGGEKRDEGRNQWPERLESLGILGGGVKRKGEDASSAITAIHVGNDSTSRTTSRSPSLKLPLQGSRTSSKTRQTAAAATPTTTTTSAPASRTASTLGISSSGGRKSKKTGSRSGSHSPNCKKDELSAQRWSAVKVLEEYDPNNLDEVSRPYAYVADHVVRVDGAVDILAEVRRYEERVQQRQRQKREEEEEEVGGRDNKANRDSGGSGGSGGRGDEEYHDALEHLEEQNAKQEKEQTWIEQLRDELQRGEEIKWYVVVNGDEERNYSNSNDFDDSEDDEDEDEYYAEELSSESYYGGGTYHHDTSEDLSASELLTNPSLAAHPPTEDRRPSLLSHSGSRTSSSSRGQSKSRSQSRSHSRTRHRNHSRQRHGDRHRRRPKPTKEQRQHHAQYTLQQELFERNDLRASSSAMATPTSTPRTTTVAATRGTTTTTTTTTTGPPPTAMRNMNTKAIIKEGAARRVISEGGIHPALRGGPKNPEIPIIMVTPTRMTFPTGTVASGKRVVEQQQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQGQQNEYQTKSSSAGGSGSGSGTSSGMGIVSSAAAATSSFSLETSPSNVPASAPAPTPRRPNPRNPTTTGHGHGQSTGSKRSSLTSLRTLSWSCLNFPVHGHGHHSTSPENKDTSEAVSPPRPSPSPPIPLHPKGSYPSISTLPPRPAPPPPASAAQRPGRPLTPPPPLGQSDSNKVPTAPSSPVVIKISATPAEALEAQAAASPPVVGQYSSKTMPTRKGNQGYGSRKRRSSGSLRRLFQRTSGKEGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8G8</accession>
    <name>A0AAE0J8G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_474756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678225.1">
        <property type="nucleotide sequence ID" value="XM_062827266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8G8"/>
    <dbReference type="GeneID" id="87864420"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="103"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="443" mass="49038" checksum="D448D10C38AB5AD1" modified="2024-05-29" version="1">MAAITTAVDTAGPTSSEEVHVAPSLPLTQKLKYGALAYGITKLVMTPVNFINSIKTDYLGSSPNKPDIIKALPSRPQLPVRVFLPKSHSPSNPERSHEKLPTLLTIHGGGFVIGAPYENDGWNRRFVQIAEEAGTPFCVIALDYRKAPSYPFPTAIHDLEAVILDLLVDYGSDPSTAVVEKHSDLPIDTHRVASAGWSAGGNLAMAVSQLPDIRHRIKAAVPMYPVLDFVTPSVAKTKSRRYKLSLGGFRGRDTDYLMSVSGMFDWSYVSPGQKMGDPLLSPLYAVEVLEEEDAEGTQGRVTRVKGRERFPANVFIVACELDMLGGEAWRMACKLAGRRVPGVEEMLGREEPGPGEKKEGKKGGLLELEDERFHWQEEVTEMEEDGRQQVKRSYRWLLVPDVVHGYDQDGISRIKDEEAVRNGMEKREEVMEIVRGWLVDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8Q2</accession>
    <name>A0AAE0J8Q2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="9">HIBADH</shortName>
            <ecNumber evidence="3 9">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_475446</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 9"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678479.1">
        <property type="nucleotide sequence ID" value="XM_062827311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8Q2"/>
    <dbReference type="GeneID" id="87864465"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000630">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="28"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="206"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3339119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="338" mass="36130" checksum="D51511A2DE5F6A72" modified="2024-05-29" version="1">MRANTRLCKQLFAQRRTFSSTARRLDNYAFIGLGQMGYQMARNLQSKLPPSDTVRLYDINRGAAEKLAQEMSAQQAGGASVHVADSAADASREADTVVTCLPEPQHVKATYESILKAELPARPGPRLFIDCSTIDPTSSREVAAAVDKALPNGQGHFVDAPMSGGVVGATAGTLTFMLGAPESLVARSEIVLQRMGKRVLHCGPQGAGLAAKLANNYLLAIENIATAEAMNLGARWGLDPKVLASVINVSTGKCWPSEVNNPVPGVVETAPAIRDYQGGFGIGLMRKDLRLAILAAKEADAKLVLADKASEVYETAESEERCKGRDFSVVYRWLGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8Z3</accession>
    <name>A0AAE0J8Z3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_290302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678465.1">
        <property type="nucleotide sequence ID" value="XM_062823001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8Z3"/>
    <dbReference type="GeneID" id="87860155"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="254" mass="27578" checksum="77717F6159D4BF8E" modified="2024-05-29" version="1">MTVDAVTPQQITVGVLALQGGVIEHISLLQKAATQLSSQSTESPTPTPQFTFIQVRTTAQLSQCDALILPGGESTTMAIVARRLGLLDPLREFVKVQRKPTWGTCAGLVMLASAASATKQGGQELIGGLDVKVLRNRYGTQIQSFVGDLRLPFLEEEKPFRGVFIRAPVVEEIITSSSSASEKQRAEQVEILGTYPKPQGTGKGEDIVAVRQGNVFGTSFHPELTDDVRIHVWWLKQVVEELRSGRGEGVQLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9L4</accession>
    <name>A0AAE0J9L4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="9">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_476574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678810.1">
        <property type="nucleotide sequence ID" value="XM_062827373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9L4"/>
    <dbReference type="GeneID" id="87864527"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3339450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="92" mass="10763" checksum="4177E8CD6DA74484" modified="2024-05-29" version="1">MTGRGGGGNRRVLLPPINFLFRLLQQHSTVQIWLYEQLHIRIIGTIRGFDEFMNLVIDNAIEVKLVSKTNEKEERRELGVRIFLLLWCERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9R8</accession>
    <name>A0AAE0J9R8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Penicillopepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_285517</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678307.1">
        <property type="nucleotide sequence ID" value="XM_062822939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9R8"/>
    <dbReference type="GeneID" id="87860093"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF23">
        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042234338" evidence="12">
        <location>
            <begin position="20"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="124"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3338947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="434" mass="46461" checksum="CDCD0EBC48E318A4" modified="2024-05-29" version="1">MPVLFKLFILSVLLSLVVAAPYTKRSFKVERIRNPNFKARNGPRELLKAYRKYRMPVPQPLLDAMNAQRNGTTPTITSITQEDFSESSTPDTSRIDAIGGSGKAAAGTEAGAVTATPEQDDVEYLAPVTIGGQTINLDFDSGSSDLWVFNTQLSPQITNGHQVYNPAASKTFKLLQGQTFSISYGDGSAAAGNVGTDVVEVGGVAVQNQAVELATQVSQTFIQDTQNNGLLGLAFSKLNTVQPQQQKTFFDNVLPSLAEPVFTADLRHNAVGAYEFGRIDNTKFTGQMAWIPVNTGMGFWQFTTSAFSVGNGQAKKVAPAQAIADTGTTLMLVSQAVANAYYSQVQGAQNDPNAGGVTFPCNANLPDLFVDVGGRYMARVKGDDIRFSQIDATTCFGGVQPTTSGLEIWGDIFFKSQFVVFNGGNNSLGMAQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA98</accession>
    <name>A0AAE0JA98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_540959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679170.1">
        <property type="nucleotide sequence ID" value="XM_062829166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA98"/>
    <dbReference type="GeneID" id="87866320"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="276" mass="30422" checksum="24F2A4D087056117" modified="2024-05-29" version="1">MASVTQDYKDNRGNSGGEVSQFKFAFQSSTGPSLTINFFRVGVARLQDFRSINALNGGGSGMMYLGDELTGRHVQVPGLQAPRDITPTPRTAPWKHGSMTAASNNDRHLSGGGMVRNREIARGGAWEGRSVSGQLVSGCTVWSKKFDDGSLNTKQNTLRHVSWPSTSKVAWRHAVGENCTRRNIGAYEDAPAPRLASRPSFPFSGRHVKPAPPWRVCETHRSGKVGRWARWAARKTGVPTLLAFTSNIFALMMCLDFHLRLVFKLCLGLSRPNHWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAA4</accession>
    <name>A0AAE0JAA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_510384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679148.1">
        <property type="nucleotide sequence ID" value="XM_062828396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAA4"/>
    <dbReference type="GeneID" id="87865550"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="90"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="417" mass="46050" checksum="9287CE1F5A8D846A" modified="2024-05-29" version="1">MFSRAARLSTRVAAPIRARVAAPRVVIPSIAARRSVTTNAASAQLEKPLPESEEEPFQVTLSDESFETYELDPPPYTLAVTKKELKQMYYDMVVVRQMEMAADRLYKEKKIRGFCHLSVGQEAVAVGIEHAIQKTDDVITSYRCHGFAYMRGGTVRSIIGELLGRREGIAYGKGGSMHMFTKGFYGGNGIVGAQVAVGAGLAFAQKYTGGKKASIILYGDGASNQGQVFESFNMAKLWKLPALFGCENNKYGMGTSAARSSALTDYYKRGQYIPGLKVNGMDVLAVKAAVAYGKEWTNNDNGPLVLEYVTYRYGGHSMSDPGTTYRTREEIQRMRSTNDPIAGLKQHILEWGVATEEELKGLDKEARAHVNEEVAAAEAMAPPEPTQQILFEDIYVKGTEPDFIRGRTPDELFYFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAD1</accession>
    <name>A0AAE0JAD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_258264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679349.1">
        <property type="nucleotide sequence ID" value="XM_062822583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAD1"/>
    <dbReference type="GeneID" id="87859737"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="90" mass="9982" checksum="BD8EBB81175DDF45" modified="2024-05-29" version="1">MSTFLLFRLMGIMSVLCVLCIKCTSMTVCISSNLVYSSHGKLECLPVLLCLLAFSSWLPILLLYLSHCPHTCTRVILKYCVIPIVNMGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAD4</accession>
    <name>A0AAE0JAD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_476911</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678961.1">
        <property type="nucleotide sequence ID" value="XM_062827397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAD4"/>
    <dbReference type="GeneID" id="87864551"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3339601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="273" mass="31019" checksum="62EF57E36B598D0D" modified="2024-05-29" version="1">MSPSATENGAKANGVIETDLGIVPVPKVEGDWTVDKAVDTIGTGKYTEASNSPIGYFHLLERLKTTKREGWRRFDINRGESISDHMYRMSMMTMLAPASLAEKIDVNRCIKMALIHDMAESLVGDITPVDNVPKTEKNRREASTMDYITKRLLGNVDGGKQGEQIRAIWQEYEDSKTLESLFVHDIDKIELLLQMVEYEKRGKGKLDLGEFTFVKTKVGLNEMRAWADEIIKEREEFWAGKEHIRRDGGDEGVITQEKEKMQEAYYAGHGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAI3</accession>
    <name>A0AAE0JAI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_510546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679344.1">
        <property type="nucleotide sequence ID" value="XM_062828410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAI3"/>
    <dbReference type="GeneID" id="87865564"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3340402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="108" mass="12308" checksum="FCD2C8CD3B0A59F9" modified="2024-05-29" version="1">MPQYASRDVGDPSQIKKNKQSMADLKLRRLTELNNRLREDLERERIPSFGTFAGRNSMRLTVVSFSPYSIIAYCNSTRDYMVPSVWGPVPKSEDPYLPQQSSGCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAM7</accession>
    <name>A0AAE0JAM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Phosphoribosylglycinamide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_263190</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679484.1">
        <property type="nucleotide sequence ID" value="XM_062822645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAM7"/>
    <dbReference type="GeneID" id="87859799"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="113"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3340542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="789" mass="83680" checksum="906B54D1E00FB31F" modified="2024-05-29" version="1">MSSLRILLIGSGGREHALAWKLSQSPSVESIIAVPGNGGTAGVPKVTNNNTVSENDFAALVDLAKKERINLVVPGPEQPLVDGVENVFREVGIPVFGPSKDAARMEGSKTFSKDFMKKHNIPTAAYENFSDYEKASEYLKKVGHNVVIKATGLAAGKGVIIPESQEEAQQALKDIMLEKQFGNAGDEVVIEEFMTGDELSILSFCDGTTIKSLPAAQDHKRIGEGDTGLNTGGMGCYAPTKIATPALLAQVEREILQPTVDGMRKDGFPFKGCLFTGLMITPNGPKVLEYNVRFGDPETQTVLPLLKSDLAEIMVACSGPLPLLKYVPVEVEQKFSATVVVAAPGYPNSYPKNIPMQVSTPPAGTNIFHAGTKLSGDYLVSSGGRVIAAEAVGESLRAAVDKAYEGVKLIQFDGMYYRKDIAHRAFRDDKSSSDKLTYAQSGVSIDAGNELVDRIKAAVATTRRPGADAIIGGFGGEVDLSQAGYPGAPIIVGAIDGVGTKLIIAQKMNKHDTVGIDLVAMNVNDLVVQGAEPFMFLDYYGCSKLDVSVAAAFVEGVAQGCKDAGCALVGGETAEMPDLYTGDDYDAAGAAIGVMKAAQRLPRKEAMAEGDVLIALASSGVHSNGFSLVRKVVDKCGLSYTDKAPWDSSATVGESLLTPTRIYVKPLLKVLAQTGEAVKGMAHITGGGLTENVPRMLPKHLAAEIDVATWEHPPVFKWLRESVIPTEMARTFNNGIGMVLAVAPEAADAVVKGLEAEGEKVYTIGKLVNREGGEKGEWCVLRNLESWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAZ3</accession>
    <name>A0AAE0JAZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_528720</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679286.1">
        <property type="nucleotide sequence ID" value="XM_062828900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAZ3"/>
    <dbReference type="GeneID" id="87866054"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000234">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000008">
        <property type="entry name" value="DNA ligase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="437"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="746"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="973"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3340344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1063" mass="120331" checksum="531B1FEEE9067A9F" modified="2024-05-29" version="1">MNTNRRSRSPDEEALEEDQHQYGAGTLSLEELDEHFPNRPRNHSKTFPFSDLFRTLFNPLIDCKPSTSGTVRGPKPGRGGHFSKVSYHEQRRHIIERFMLRWRSEVGNDFYPAMRLILPDKDRDRGVYGLKENTIGKLLVKVMKIDRNSEDGYNLMHWKLPGGGQSGISRSVGDFVGRCFEIVSKRAMCAQPGGMTIADVNVMLDRLAGASGEAEQLPIFEEFYRGMNAEEMMWLVRIILKDMKVGATERTFLNLWHPDAEALFSVSSSLRRVCWELYDPEFRLEQHETGIKLMQCFQPQLAQFQMTTTFEKLVKNLGVTEENQEFWIEEKLDGERMQMHMQEDDTVPGGFRFAFWSRKAKDYTYLYGESLGDEQSALTRHLHKAFDDGVRNLILDGEMITWDIDIDKMVPFGTLKTAALEQQKNPSKAGPRPLYRVFDILLLNDKPLTEYTLNDRRRALERAVVGVHRRLEILPFERATSPDAIEPLLRRVVAEASEGLVLKNPRSRYSLNSRNNDWIKVKPEYMSEFGESLDCVVVGGYFGSGRRGGTLSSFLCGLRVSQNFIKSGKAATAEKCLSFFKVGGGFKAEDYAEIRHHTEGKWHDWDPSSPPTEYIELGGGDRLQYEKPDVWIRPSDSVVISVKGASITPSDQFAMGWTLRFPRFRKLRLDRAWDSALDMDEFEALRGKIKDQEQERKKMEMENRKRKPATKRARKDLVIAGMSDPYSLASSSATPVIVAPRETREASTHLFKDLDFCVLSESLKPNKMAKPALEKLIKDHGGRIHQQVMDRRSGEGKKIIIPIADKNVVKVASLKKAMPEMDIIRPKWIFDCLAQPMSQKEKGYLLPFETSHLFHAGSEQTQEEAEQAADKFGDSYTRDLADTNELKAVMDGIESDDYVSDSDWDSDSGGGRGVGGGFDVNYFLDHLEAQGTSLDELRSFMFRRCRVFFALASNGTSDGTSAAVVCENKALRLKNYVRFGNGKVVDELETATHVVVVTASSGSGAGEESKNAKTEEREMAAEIRYKISLGEMGSPVPRIVKGEWVEESWKEGTVVDEEGYVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBQ8</accession>
    <name>A0AAE0JBQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide hydrolase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_277719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062824792.1"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="332" mass="35055" checksum="ECB8EA5A36DBBB79" modified="2024-05-29" version="1">MSFRPSSRTSSSSTSSGSSTRTCREKRLPNSTAVDALVYFCGRDPRKVKAMRVYETTYLDNDTSDDFDTRSSSSSSKRSTHSGLSWVSGGSNSGRTKQEFYFIESRGGGYWPGGGAGYQFGEQPAPGTAPGKKWKPPKNESGRESRSSRRSSKSGGSHRHSQGHRRQGPPSDISEEEEEEEVDDGTTNDSASVSDDGSGSGFNEYVYRGGGGPGGPTSSSYSPSPFPPGQPGPGMMPPPFSSPAPPPPGSYPPGGGFPGYHPQQPMYNMGGMGGGPTPPMSSMTPHGGFHHLPHHPHHPQMPTPGPSPPPMMSGGGGHFQQDGNGIQVFMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDK7</accession>
    <name>A0AAE0JDK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_231533</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680636.1">
        <property type="nucleotide sequence ID" value="XM_062822192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDK7"/>
    <dbReference type="GeneID" id="87859346"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="19">
        <location>
            <begin position="52"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3342843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="319" mass="34908" checksum="42289FE8B077780C" modified="2024-05-29" version="1">MSSQPSTGMATPVTYPPPEQASTGNTMVPYTFPQAKLKLRQTQPGRTPLVLVACGSFSPITFLHLRMFEMASDFVRFNTSFEVCGGYLSPVSDAYKKAGLAPGHHRVEMCSRAVEQSSWLMVDPFETVNCDENGEPAYVPTARVLRHFDHEINTVLGGIEGTDGVRRKAKIALLAGADLVMSMGEPGLWSPVDLGVILGEYGAFIIERSGTDIDEALATLRQYESNIWVISQVIQNDISSTKVRLFLKKDLSVRYLIPDPVVEYIEEHGLFHDEQSSKKKNNDSSSTGGKDKEKEKPTVADGTNTPSSSAEQVGTTQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDN8</accession>
    <name>A0AAE0JDN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin-capping protein subunit alpha</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_540510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680743.1">
        <property type="nucleotide sequence ID" value="XM_062829154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDN8"/>
    <dbReference type="GeneID" id="87866308"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="10">
        <location>
            <begin position="93"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3342950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="653" mass="71166" checksum="E6B6FE741F9B678A" modified="2024-05-29" version="1">MRGSTIRPKAQCLRSLSRSLVQRPSTGLRSVPIAATLAPSLPSKRAYSTHPPHAKLNLPTDYSTTPLLAQTSQSALNNPELSAEVRNGPTKRMNMFQAVNDALSIALAQDESVLIFGEDVAFGGVFRCTGKLAETYGADRVFNTPLCEQGIMGFAIGVAAEGMRPVAEIQFADYVYPAFDQLVNEAAKFRYRDGSCGRSAGGLTVRMPCGGVGHGGLYHTQSPESLFTHIPGLRVIMPRSPLQAKGLLLSAIRSNDPCVFMEPKILYRAAVEQVPTGSYTLPLSKAEVLKEGKDVTIISYGQPLYKCMDALQKAEKDFGVSVELIDLRTVYPWDKETVFQSVRKTGRCIVVHESMVNAGIGAEVAAAIQEDSETFVRLEAPVVRVAGWSTHTALMFEALNIPDVANIKALTSSTPNLLNELGPAFQKYNEEQFATVKLPGGSQLVIISSHSSLGDGRYYDVESSSSFAYDHITQKASDVQSHVPEGEQADLVKSTIKGLSAYVKEHFPNAAYGAYSIENDSKVAVIIVANKYSPNNFWNGRWRSLYIYDPSNSSIEGSIKVDVHYYEDGNVRLLTNKTVTATVSSGTGSGIAKEISVNEKKYQEELNKSFTSLSEGAFKGLRRQLPVTRQKIEWDKVASYRLGQDIGGGSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDW1</accession>
    <name>A0AAE0JDW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_427924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680786.1">
        <property type="nucleotide sequence ID" value="XM_062824719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDW1"/>
    <dbReference type="GeneID" id="87861873"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="764"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="826"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="869" mass="89734" checksum="7C04C6A01B37CCD0" modified="2024-05-29" version="1">MGTFTFRWPHAAEEVYVTGTFDGWSKSEQLDKVGDHFEKTVTLPDFTEKVYYKFVVDGRWTTDHTAPQEKDHEGNENNVLLPENLIRTTDPSTQEPEQQAMSNENRKVEGSSNTGEPSFAETIMSALNTVTPDSTAQSVSNPLENKKNHGPPGGWVETPAADGDKTFSVSPLPATDGALNPIDLKPGEKIPDSFSAQNVNTHVTLDKESYEKSDRIPGVDFSTSPVAAPTVTTDAETEFKVNPLPATEGALNPFKLAPGEKIPDDVRAADINTNVTLDKESYENSPDRIPGLDAALPPISKNMIPESSLPITSNNDVFINTVTPISTTAALAAQVPFDEPAVPEAVRESQEKAHVEPGASGMAEEVKVKAAVEDELLHKVSEVPSTSEGTAGYGTEKAETDLSLADAVAFAGNAAAAAVVGAATVAADKLPGVLESTANAAVNVGSKIPGAVNATANAAVDVGSKIGQTASEALGTTANAATNAAYAAKDTTSDVLGSAANVAASAGTQVQETAANTASTVQQTTADATSTVASSLPSVPDVTGHLPQAVQNILPTSFQPAFQNGQALPTSAEVERSLAAEKASRVEGISAAVPIEVKDSIEKAGESPEATTNAAAVLEKQAVEAELLREVKPTQAEPPAVAASVPSEVRDSLQQADESPEAAAYPAAVEDKKAVENELLKTVKPTESVPLALASAVPGTVKDSITKAGKAPEAAANADVVAEKTAVEAQLLQEVKPVEVVADKKAVEAELLHEVKRTEPTGESSTKATTNGTATNGSAANGSPANGAAANGSTAAASKPVETPVTPTTPTATEGFHAANGNGKATEQPTVTTGPETTTTTTASASTTPERKKKNRVSGFFSKLKHKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE08</accession>
    <name>A0AAE0JE08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_245986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681129.1">
        <property type="nucleotide sequence ID" value="XM_062822397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE08"/>
    <dbReference type="GeneID" id="87859551"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="703" mass="75407" checksum="48C0FD7950C001CF" modified="2024-05-29" version="1">MAARPHVEARSLSTLNSLAANPPQYPHSADVKESLTLYISRVPGSRDVILSPFRPQRKNVTVEDINNALYLIHLDLPTDELLVENTRPNETSTAASPRTSGESARSVIPRKPLPPSARVEIPTPRQPPATASATQNENNAPKNTGPVPTRSPSVRRTSSVRRTGSVRRPQAPGLERVERAVAAQAPVAGKDGYTPNPMFQPSLVSEPPSRPALQLPPPAENLAAMRRSFGPRPQTALTIPEEPVVSPGTTTPTNNRPITPTDQTLYTPTSNVPRPGDGILSPSTVTRARAPSNSKLAATIPFTLTLIRRDPSTNLQWNVGKISSFETNIPTPESAHPDLGEPHDASTTEQPPPIATQLIDVHLETSGYAKYRGMPSRANIEALRPTSPQSFARTLQGLGTGSGSTSGNGSLGSLGSSGSPQKQIMGVAHREVEEGFHRQVVMAYTKSWTSGFKGAFKRHSRSGSASATVGDISGHARHGSSSTIGSADISPNEHQTPQSPPPNHNRQESMGGGQLITQPGPNLRPKGYVFLSPWLGRCEFRTGSTGRSLKCRHILDEHTGGITQIDPAKLAQSVRDAPTIGQSRGDSLSSAITGAKPVSELRFNLPSEPRSPGAGGENSTQTGSKRHRFTKFLGLEPPSSEEDYFDDEDIMDLALGREDAGGGSRGKRAKLGKLIIHDEGLKMLDLVVAANMGVWWNTWEKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEG1</accession>
    <name>A0AAE0JEG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_244984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681071.1">
        <property type="nucleotide sequence ID" value="XM_062822378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEG1"/>
    <dbReference type="GeneID" id="87859532"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3343278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="537" mass="59413" checksum="9A4BBD72B64FD646" modified="2024-05-29" version="1">MTTDQAKTTGRHLAHSHAKEGDIPGTVNLQVAEGDDTAYGQALFPVPANDPNDPLQWSQTRKILILVVCSLYSFLSNSALQGPSVYIGIYIQEFGVTPTAASDLVNYANLAYGFGSLLMVPLYHKIGRRPVMLASLLLYCGGLIGCAQSKTYASLMACRVIHCFGASVCEALPVQLVNDIFYLHERGKRLGIYTVCLCVGATGPLFAGYMLDGDYSWRLFFYVEFAFAGALLILAFFIVEETTYHRKVPEEVTRSSISLNDKELASDLMVTTSEDLPPRKTFIQTLKFWGIWEKDSQFFLMIARSFTYFLVPHVFWVVTTYGIYIGLGALTFNFIFPLKITSPPYSWSETSSGLIALGSLSGYILAVPFTSSSDRLAARLTRRNGGIREAEMRLGVILPVMLIGPAGLVIFGFAAERNLHWFTYFVGSAMTTFSGYFYFTFTLAYSIDSYTSNVSEMLIAMNLGKQAISFGMGLKLLDWVVEKGYAVMIAGVFGGLLLANNLALVGFMVWGKRVRAYMAKTWLARVHRESVTEVATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGM5</accession>
    <name>A0AAE0JGM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Taurine catabolism dioxygenase TauD, TfdA family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_460649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682584.1">
        <property type="nucleotide sequence ID" value="XM_062826546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGM5"/>
    <dbReference type="GeneID" id="87863700"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="101"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="498" mass="55805" checksum="D7B473400602DEEF" modified="2024-05-29" version="1">MAMSLHWLRDTCKCPHCVNPDSGQKSFSSTSLPEALEVQSAEVNAADGSITIVWANDTVSTNATTHTSTYDASDIFTWQLPYDLAGNLLPVERTLWDRSKLQAHIDSGDLRVSYNDWLTSDAAFWKAFESLARFGILFVHSIPSDRALVESQVEKIANRIGILMHTFYGFTWDVRSKPRAENVAYTNVFLGLHQDLMYIDPPPRLQLLHCIANSFEGGESLFSDGARAAYSLELNNPAAFDQLRGNRSPQFHYHRNGNDYHMGRNTFRYAGRTGQGNGFLSRIHWAPPFQAPFSRQTGATATNVLGNRVIQDGGGGAYAEGEHSMVVVEEKGKNMTKWVPAAKEFEREISAEENMFELKMKEGECVIFDNWRVLHGRREFQTEGQAEGAERWLKGTYISHQVYKAMEDKLQWRLAQKEGGIPLAIGVAEAHGLGWKERGQLPQKEAPKEETTAPVQTEEAPKTEETPKVEEAVKPEGTQNEGPSRQPEEQLGTVNWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGQ6</accession>
    <name>A0AAE0JGQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_150752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682629.1">
        <property type="nucleotide sequence ID" value="XM_062821075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGQ6"/>
    <dbReference type="GeneID" id="87858229"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="112"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3347547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="645" mass="73545" checksum="B64B911B6C52FA64" modified="2024-05-29" version="1">MEGNPATQSWPAPWHHILPSPTQHTDNAAAADEDPHHRQTPRIHAEPLDLDVYTTESQSFCSATDSNSERVAEYMASQQRLHPFSPLLSILGRVDTDERDIADQVNNLPEQTSPLVHLPPELLEGIFDHLSAIDLVAVSATCRHLRTIATSEFRWQGLVQENVPGYRVTSCYPYTLFRQLYKAHDPRWFLPKYKIWFADDSLYGRLIIARFDQRRGCIEGYQLVASVPNNDLWDDDVLDNGTMIRKHDFRVGLHLDQPVFQLDPENQSPESDNATVRLWQDLDSVRYKDDPTKPKPHFKVEVRAQGGSSISAGSRSRSFHTNFFLAKAQRLRNAIHDAEELMDAHDVRDLLHSDLSRSLSPRDYLIRSAIPGIGGGDGLRNAVPHGMMTILRDKYWPPPTIEAPHRVANVGPVGVNGGYNAEATSKILQSPPATRAEISDHAFHLRRWVEFGRVMRAHIGEELVTYSTLDERLYTPTPEKPYRGIFVGHYGPHGCEFILMHQPDDEPRVRDAQIERRENETDEEFQKRNQESKVYRGGLAGIKLTGDPNVPRGEYTFVAKDIGEEGFVKVAEEEEFAGARVVKAKGHVAEHNFRDDDWIDCDLFLASHNRLALHWHRWDMTSVFERVDIGKFIVPELYDGPWFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHI6</accession>
    <name>A0AAE0JHI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_538339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682696.1">
        <property type="nucleotide sequence ID" value="XM_062829085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHI6"/>
    <dbReference type="GeneID" id="87866239"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="244"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="739" mass="84248" checksum="161773AAD5272602" modified="2024-05-29" version="1">MSDKQTQASHVPDGEGRLSSHSAACWQLVAKIPFFRQVDQEQEEDGNSLNLCQRCKEIDLNGIFNDTSVFFDSETVLFLGILDKESTCALCRLFYSMRRTAPDGKPTDSYNLRKYCFGEFFDAEECTLWAVDPAKSSLLQLGKFSAKPTLLDMRHSWFIPHSPSSDFNQPMRPWPNKRAVKGLPVKETSVNYPLLRCWIKECEDDHPGCSLRSSEPTKSHTGPTIRGIDCRTRKIVELQPGDQYIALSYVWGNKPFLENKGNRALPTNAPKVIEDAMIVVRELGQRYLWVDQYCIDQHDEQAKHAQIRNMAHIYEGSYATIVAFSGENSSCGLPGVSSTPRIPQPRFTSSRLTLLGFTPVLTRQSFEASIWSKRGWTFQEALLSRRLLIFAPEQVYFHCPSGIWAENSTPAPRLDVSSYIDHQSADWKREMRSIFPLTRVHDSTYGFQVETFDIQDLLPLIEGYGRRQLSFQADALDAFRGLLSRVSIVTYWGIPAYDLPQSHRGSFVLDGSEADALFLQCLFWIPLHTATRTQYLGRREGFPSWSWLGWRTPVTFAWHYPKYDIDAMMLPTVKVEDENGALLSLVDVIESSGTEMERSRALPERTTYLWLEGLVLTLGFQRGSRRDGRPFRFCLNHPLGYSDPPCEMRDSCKQRTYASGGLLARHNQIEFRLEAMGPIEIYERILERTWDCILLFTRDPSELYFLILDEGDDAAYCVGTLCVGDSSGDLIEKLKTKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHN4</accession>
    <name>A0AAE0JHN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis, uroporphyrinogen III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_165153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683160.1">
        <property type="nucleotide sequence ID" value="XM_062821286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHN4"/>
    <dbReference type="GeneID" id="87858440"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="303" mass="34168" checksum="BA7ED0580B2DB00B" modified="2024-05-29" version="1">MSQKTPVFLLKTKSTPGDSYQEQFSSETDGFNFEPFFVPVLEHRFKDEGLATVRNLLKTKAIGTGSDCAYGGIVFTSQRAVEAFTHLVQEVTGDDRWPHLQDIPVYSVGPATTRTLKAVPQQPPLQVFGEHTGNGETLAPYIIEHYGEWYKDRSTKPPLLFLVGEQRRDIIPRKLMDPALPSDKFIRIDEVVVYGTGVMESFQEDFTKLLKETEDHPARWVVVFSPSGCDGMLSALGWLNESSGRVGDDFRQEDRKTYIATIGPTTRLHLVKNFGYEPDVCAEQPSPEGVWEGISRFWNESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI01</accession>
    <name>A0AAE0JI01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_158167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682961.1">
        <property type="nucleotide sequence ID" value="XM_062821196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI01"/>
    <dbReference type="GeneID" id="87858350"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF20">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3347879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="583" mass="63723" checksum="71DC845456460E2F" modified="2024-05-29" version="1">MGGGGGSGAAGFYDAALQRREAMMGKSGPAALVKNFRVFSIACFACIGGVLYGYNQGMFSGVLAMPAFQKHMGEYDPIDPNASQTKKGWLTAILELGAWLGTLLSGFMAEVLSRKYGVLVACLVFMLGVVIQATSISGGHETILAGRFITGMGVGSLAMIVPIYNSEVAPPEVRGSLVALQQLAICFGIMISFWIDYGTNYIGGTKLETQSDAAWLVPICLQLAPALILFFGMMFMPFSPRWLIHHGREAEARKVLSNLRGLSQDHELVELEFLEIKAQSLFEKRSVAELFPELREQTAWNIFKLQFVAIKKLFQTKAMFRRVIVATVTMFFQQWSGINAVLYYAPQIFKQLGLGDNTTSLLATGVVGIVMFIATVPAVLWIDRVGRKPVLTIGALGMATCHIIIAVIVAKNIDQWETHKAAGWAAVAMVWLFVIHFGYSWGPCAWIIVAEIWPLSTRPYGVALGASSNWMNNFIVGQVTPDMLNAIPYGTYIIFGVLTYMGAAFIWFFVPETKRLTLEEMDIIFGSEGTAQADNERMEEINAEIGLTQFLRGDSGANHGAATGSDTGYGAEKEKGEHYAEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIE8</accession>
    <name>A0AAE0JIE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_156863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682897.1">
        <property type="nucleotide sequence ID" value="XM_062821166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIE8"/>
    <dbReference type="GeneID" id="87858320"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="743" mass="80560" checksum="CC9E5ECB660D8D2C" modified="2024-05-29" version="1">MFGLESSGSAAEPSRPASLFRTRTQHSTRSHQSIFKEEFNSDLSLPLSHHHGHHRQVPYHHQNGSIYSNYKPVTGAKPYRPSTDTGGSTLDNDRERERAGDPEQEAMATPTAREVRRLASHHDFIYDTSSKSRRLGWWAFVGRHLSLPAAFLAGIIFVIVAIVFTTVTSKRPLECPDWAEDCRTIDRWTAEHLPTVQGIITLVYITGLGALAYVALALCEAAVWPLVVKQTMTMRGLEAYLATTRGSILAAPRALKEVKTVAMGVMLVSAVAAILTPLAGIPLVGQAYTSTSREVELKSNYTPGGGLAESFMQTEAPSFANMGVLTTYNSWAMDPASEPLPEYRNWYVDREVLGTKGNFSARAVKLQTTVSCSPRTVEQLVRSGKPLNAFPTNWTRTNISSLRGEKRTPAEVYVRPYPQLTLWADNFTFEASHRTKATLVFAALNGTIEGGKQSSIALGTMNSVSAIACEVVVAATDDIITVGNPLIHSDNTTLPTLSSLETLQTNTSSPSTALNELLLWFAVAPILSAPSVSGVQPMFSNSTSTNRAVAYTGQTSQRNTWTVDGIESFIHRSIGALLQSSTASQSGSTENTTLFTSTYPLQFLSRSRALLLLLLPLLLVTVIILLSFYLSHTHSRESIPVLRLGGLCELLKSSQTPWLREQAGTDAAKTYLPSDLGAVIVKFGVVGKEGAEMVGLGDGNGGKVGAFVREVPRRVQPLDKGKESDESQKRGTSGETVEMGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIF5</accession>
    <name>A0AAE0JIF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_508350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683545.1">
        <property type="nucleotide sequence ID" value="XM_062828214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIF5"/>
    <dbReference type="GeneID" id="87865368"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="937" mass="105208" checksum="F89505A292B79038" modified="2024-05-29" version="1">MAPTSSRKKQTLALHKPIKRPVASAPRLERPPNELPTSSSKAPKSASAPLRTAQASPGLSSRNAASALASTSSKPRGILSKSGPNTSLRKDVSVRKTKKTDARKLAALSAERSNSQLPMDMPLSTEQPASVPFPRGSRSRKAKESQLSGPKLAAMMREAEKTRRRSNSVDLGRGREEEVEMEMVDEEEQNQHQKKLEGRKLPQKRPIKERNEEREMEEEEEEEEIRERRKRQKETEKEEVVEEEEEEEAGPEEATDDVDDLDIENGSVQTDREGDVPMEDNDDDEDGQEELDDEIDSLDMDDGSVQMDREGNVTMHDVDNDYQTLDGSPQEDVELEESWENVEEDGEDTDMIPESERGEEDGDGGQSGVEEGGDAEWDGLKSPGSAIEDNEEDEEEEEEYEPEDIEREWAGGEAGGEEEEENEEEGEDEEEGEDEDESEELEDEEGTTGDSADANVGADTDPPAPAEEHAEQEVTLIDEEGNNDSTTETLPSADEEENAGIYNTVKELIQNIPSKHFVYCRTLDQPNDIQHVAFKVYDTDGKEYDFDTRNLRDDQEALGRLLSVAQGIYKKDYGWEYANLKRDCTFFMSARREEKTTKAKPKTKKKATKGKPKTQGSKQEQAPTYKGHITVVDGGGFDDDDCDDGGDEGGQWDKYIQRLAEEALDVLGTIPKVRFKPELEYMWVWGEKTLFPNYDFPKPEEDKYLAGRLMVILAGLDYEGGEFAFSCENRCHYFDPKAEPCLIATLSGGSAYVDAHPLTSGYRIGLVYQLRFPIVKMADQNTAVNAVNILNDYEKEFLDGLTTWRNRVRNADDDKPNGIHRTVYYILKKQLSGTKDFDPSADLIPAQKLQLAWLYKLCCQMPGKRIGDEVYNWQLHVDLAVLSCRTVKRKDKGGAISLRPGFEVGWTADADIETDDWNRNQGEAGMECIRLNTPSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ87</accession>
    <name>A0AAE0JJ87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_385598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683666.1">
        <property type="nucleotide sequence ID" value="XM_062823707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ87"/>
    <dbReference type="GeneID" id="87860861"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042139354" evidence="2">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="289" mass="30385" checksum="C1540BC90564C56E" modified="2024-05-29" version="1" fragment="single">MRTSRIATVLLALAPTAILGNPVPILKAGVITNDHSLAGSEKNTNHGLCNRDDHDCPTKTVDPGDLCINAHATMICTPGGEGNPNFNQNTKRSESADSINLEATYTCTGGPDNETCIFDDGRQVSCTSNQKTAALQTNTRDGGDPDFTCDTDVTGDYVCTGADVRCIIGKQGDATCSFNGPDGSDGDASKFKVNTDRLALVLSPVAPKPKDDSDPFDANPNYSCAQISDWTWSCGPNGVGPGSGNEKGKSLDIRGSDDEHYDPGQGCNQPQGFFGGCNGKRASNEKREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK42</accession>
    <name>A0AAE0JK42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_488121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684430.1">
        <property type="nucleotide sequence ID" value="XM_062827712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK42"/>
    <dbReference type="GeneID" id="87864866"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="343"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="700" mass="74578" checksum="EB4E8181DB4DEAF6" modified="2024-05-29" version="1">MMKATPTISRLLTRSSNRVLGVSLSQPVSYPLTSLLLHSSATPARISTGQTLQLAYRNGLTPHSASFSTSSPSHQEAAAVAPAPQVSPAPVADMPGVYADMAGRLDARLLKALDAMGYANMTPVQEKVLNMGSFTQDCLVQAKTGTGKTIAFLLPALHTLLNAKDLNPSQVALLILAPTRELAQQIVDECEKLVSQCNPRFECHLAVGGSAKASSLSKFLRGKPTILVATPGRLDDYLSDERVRQKFNNLRCLVLDEADCMLDQGFLPALTKILQSLPTKQQAGWQGMCFSATLPPSIHKVLHHVLAPKHAHISTVDENEAPTINSVPQSYMKVDSVDDVLPTLHNLLSAERFDNPKLKAVVFCSTARQAALLYTLFGHTGGASPAKLPVWQMQSRMNQAQRTRTTEEFKNTESGILFASDVVGRGLDFPDIHLVIQVGIPLNSEQYVHRVGRTGRAGKAGRAVLIVTPEDFWFVERNRQFPMAQSKLDHPKAAAVDSASIISQSLAKVPDQVKAQAYVAYLGFVNTMRSKMKITPAQMVQVANRYAFSLGCEEPPAIEASTIGKMGLKGVPGLIKNTGPSLRGQRNGGNRPNQSAPRGGGRDAGRDAGRDAGRDAARDVDASFFGNGSNGGASRGGGGGGGGGRGRGGFGGRGRGGPGGAGGDRNSGFKKPRDDSAPPGSSGGSRNKRPRREDNRREAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL59</accession>
    <name>A0AAE0JL59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1365-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_122882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684763.1">
        <property type="nucleotide sequence ID" value="XM_062820698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL59"/>
    <dbReference type="GeneID" id="87857852"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="70724" checksum="6A7414385FD949BD" modified="2024-05-29" version="1">MNGLSGTAAVGSLVNYVGFLTFYAGFLDATLLAFFILVRNGFFGRTTIQICAGVAKLSAAAAVVFLFFQLFQIFRLRWTSVETPGWDGPGQVLLLPCRTTHTRLSPKSHTFSYAYLVVGVPVGYRGNAANMVSVGVKQTSGWASWFSSSSRPQKGWFDVDASDYLQRQSGELTLREKLDSYLQIQGVDPATYPHAYLVTAARFLCYHFNPVSFWYLYDSHKSLAAMILEVNNTFGERHMYFLKRDHVPGSLNYHLQGNPADYENQIAGAIEEQANGIPFTQAWPKVFHVSPFNSRKGYYSMIATDPLSPRNNGKPIVDVTIRLSTSEGHDKLVARLHHEGPAIDPFSMTTYQKARFIGAWGWVGFATAPRILLQARALFFYRQLHVWFRPEPSKGTIARNANPTESQLEKVFRRFLRHLVEKATIPLEVSYIASGIAHDTERMLSHQATDGKPSIERLEFKVLTPAFYSRFVYYAHDIEAFFSEMNENCTIWLSNPRVLPALALRKTFPPPLSITNPWEFLAFKCIQHLRRRPDPIERPLTSNAVPRTRQAAVDIRNFRPSFMDAYVLTHEDPATKAAYKECVLKLFLADRIAFGYVSVLEVQRFVALAWFAWMLACPPWRGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLA6</accession>
    <name>A0AAE0JLA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_132905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685044.1">
        <property type="nucleotide sequence ID" value="XM_062820834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLA6"/>
    <dbReference type="GeneID" id="87857988"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041987668" evidence="1">
        <location>
            <begin position="19"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="404" mass="42589" checksum="6C5911C7793FDFB3" modified="2024-05-29" version="1">MVRKNIILSSLLLGLVSASPLHQKRQELPFESYDESVAAGADSTDAPPVGDAVPQTVSTFDPDAVAETVVATVVDTPPAEAQASTDAPPEVITVTNLLKRTDAPATSCIVRTSNGPHVSSPDTPEAFTSYADFATAATDATKAANVPSGYAVVPNFVNLKAVAKDKSYITYTSSKLSFYDPKKCAAICDTMAGCTSFNIYYERVPLEISKATQVPDAALGCPGNADATSATLIKCAFYGMPLVASTATEVYQFQGKAFKVVHAGSTAFTKSAGPSVDGFQGPITFGNNGDASINAPAPVIDHGYLRSQTFGTNVPFSPELCAASCNAQTEYNKLHNINKGQACVFFNAYIFYKNGKDGVFTCAYYGIPYGASFAKNKGQRDNSGNVWTVGSSYGYYAPGFYTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLI3</accession>
    <name>A0AAE0JLI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Indoleamine 2,3-dioxygenase gamma type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_421437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684736.1">
        <property type="nucleotide sequence ID" value="XM_062824340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLI3"/>
    <dbReference type="GeneID" id="87861494"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="513" mass="57799" checksum="AEF934704B554826" modified="2024-05-29" version="1">MGSLGTDTTTYHEDFPILHDPRPDDASLPAFMVSTTRGFLPRMEPIVTLPPEFDPLESILQRMPVKTASGEPGLFAQGNGKLGEVVHSELPDLTEFVDKYRHDLPLMNALYRDYSFLASAYLLEPCHERFVKGEEYGLGRQVLPANVARPIAKCAEICEFKPFMEYAGSYALFNYYLVDPSLGFSFSDPSNVRLIRAFEHGLDPTSSEAGFVLVHIDMVRHSGPLVAGAVASLDACRRSALSSSSSTDNPERTRLSARQSLNVSLSQMLAALKQVNATMETMWKRSKPNDYTSFRTFIFGIKSQSMFPNGVVYEGLPDSDGRPLSFRGESGANDSIIPLMDNLLQIPMPDTPLTKILEDFRSYRPSNHRAFLEWVKRGSEEMGLRRWALALDGTDDMAEEERDEVRRSRSLWIQVLNQVRDFRWRHWCFAREYILKQTSHPTATGGSPIVTWLPNQLQAVLGDMVGLYERMGGDEAGGLGEECKDIMELVRRQDETLKKEVRKFCEERGVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM47</accession>
    <name>A0AAE0JM47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_417977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685497.1">
        <property type="nucleotide sequence ID" value="XM_062824119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM47"/>
    <dbReference type="GeneID" id="87861273"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="280"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="525" mass="56412" checksum="5A9663838FB6D73E" modified="2024-05-29" version="1">MGGHSGGGIDPNDLAMGGNFHGSFQNNYLNHTNNPSNGFSSGSALFGDDELLDGLNSPSDPHVGMQGHGQDFGGMNDVGMNFPDSYHQSLPINQAHTNGYSSTPDGDPIASPFVHNFSHFRQMQHPQSFGTSLQSPMSYAGSPLANNDMNSDGTDPNFLSAKARTRIPQTMQRKPSTTRSPLTPKAIDMAGLSVNSGSFGPQPIRTTGPHHEKSHSAQWMQTPQSLSSFPGSGFSSPLQAGLHGPHAQINDILLKGGTSMPAKLGTTTSSVSTQEAKRKRRRESHNLVERRRRDNINERIQDLSKLVPAHRLEDEKIRKAIQNGTPLSPTLAGIPSPSQATSALAGPGARRAAGSTAGNITTGLPIEEKDKGPNKGDILNGAVSWTRDLMWMAYLKIQQQEELINALLERGGTVPFEITDDEKRMQTELMEAIARGEDGSGKSRGFSYSRTAGTGLRVPHHTDYKGEPLNTNGVNGEHLSTSPAHGGADGKFNDGLDAGDFLDYEDDGADMEFKEEDEYGMDLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMQ1</accession>
    <name>A0AAE0JMQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_459900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685381.1">
        <property type="nucleotide sequence ID" value="XM_062826493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMQ1"/>
    <dbReference type="GeneID" id="87863647"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40347" checksum="E5AC81F94578612C" modified="2024-05-29" version="1">MSNCEEPPPSYEQAMASSNTSRPGTSDTSSRPGTSGGLQAHLHTDNLLHVPGDDHHHGHDGIPTPTRLSMEDELRPLPEGWVRTYDPETNHQFFVDTKADPIRSIWHHPYDDEHFLNSLPPAERDRIEQLKHRNPGPDSHSRPGSSRGAGSRAHSPQPPRSPRRAGAHADAHPQRTQQQQQHDHDEEQKTLGRKLKDALTGTTHSERVEARAAREEAEREALQQHLLLRRAMQKAMETSRPQLLGKDDNGVDLYLEPPGHMFPGVAGVKPLTPWLSEVFYERDRSNGNVRQPGPPGRYLRPEGSMYGFGYGGGYDCGPSPMGGGRYARPQGPYARPMRPVVYGGGLGLPLMAPMLGGVMLGSLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="1 2">
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685192.1">
        <property type="nucleotide sequence ID" value="XM_062824226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMV5"/>
    <dbReference type="GeneID" id="87861380"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="579" mass="63239" checksum="F3429AFEC528844A" modified="2024-05-29" version="1">MQSSLSTEGKSIHTDLEEEFRDDYHFGALSRRDLEERWFGSGILDWLARIVKPEITREFTYDYKDTLTAKLIDETWQCNRNGIDYEGHILAQALLNLKVATSFGFTLIVTKLAPPVDVSQSYLTFYNKGEITGVLTLEAVAKFSYHKGDVIVNIPFPGASFKIPGIATIGPQLTVESNIDASLTLAGKVETRLEFANWEVRQVLPDNGDSKYTPKEIGLGDPDLKRTGDNEGLDEPNFYAGVQALGDVTAKMSAAAEFGIRFDKRWDVDPAAAAIVAEASVMLKMGVGGSTKDICPFTFGVDVGARLFARATAPGFGWPGAEVPITPAYKKPIIEGGTCPGLGPLPTKRDLNFLTIEANDTRGHSHTHNSLIHGYGHTHNSRSLAKRAAVWGPVLNVPVGSYFCPPEADDSSGPGSPCSKIGYAWDESDIIADALFRRSDPFVHVLEKRASSKPTEICGVTTKFQYPTDYDAKTLGNDIYGFKSTDCKDYAFDKLTAEVAGVSYDSEHVLEAQLISQFFNTLKNLGPFDHPNPERAQEDIKLNFCALVKLLWNAPVVIPNLETAQGTGVALTAFKHVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN11</accession>
    <name>A0AAE0JN11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_16166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685900.1">
        <property type="nucleotide sequence ID" value="XM_062821250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN11"/>
    <dbReference type="GeneID" id="87858404"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042070888" evidence="2">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="244" mass="25704" checksum="4D5F2B770DBFC3F9" modified="2024-05-29" version="1">MKFTTTTVFMGFLTSLAAAQGAPEVTPCPTVTRTMQNRGCGKTCQFTDCAFVNTVRNPCGCPASIPTATLIAPCEADCPYGGCNIEFRTSWLTCPATTTSSRRWPPWQTRTSTTTTTSSPPPKPTSTRTTVRSTSTSTSTSTSTSTSTTYTQTTISWSIITLPPKTTSKPVLSTSTTPCPTVTKTTSPADCSPIRCPVPTCQVRSTLNVPCGCTVKTLLYVQGCATTCSEGCLTRTETASATGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN28</accession>
    <name>A0AAE0JN28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_569611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685312.1">
        <property type="nucleotide sequence ID" value="XM_062830417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN28"/>
    <dbReference type="GeneID" id="87867571"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="175" mass="20892" checksum="1E6342AC976E237F" modified="2024-05-29" version="1">MPSMNRMSTNSEPLAAVRVPAAAAPPAAGYLASFLRMYPSETNSDLVHSSRGVKRKREEEEEEEQEEQQQEEEEEKEESLEESLSKVCDRVWQEVREEQQQQEELDKEIEELERKIEAQEQEYQERFGDINEYTQWQRWREAVRKAAEEYKAGEGRVKKAEKRHRGCWEMRRIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNA8</accession>
    <name>A0AAE0JNA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_449452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686109.1">
        <property type="nucleotide sequence ID" value="XM_062825953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNA8"/>
    <dbReference type="GeneID" id="87863107"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="116"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="346" mass="38675" checksum="41C3399612CEA708" modified="2024-05-29" version="1">MPSPTTTMAEQYLICTACGTQHPTTDRSSLKTCFICDDPRQFVPPSGQSFTTLSDLRSSTSPKYKNEFHPYKYSSPQEKFESSKSDSSGEPKEATIDELKQAELISIVTTPKLGIGQRAILVKTPSGKKVLWDCVAFLDEETVSKIKQLGGVDAIVISHPHFYTTHLEWARAFGDCPVYLAADDKRWRARVDDAVQREITEEETRITNKKGEDLGVVAVKLGGHFPGSLVLHIPHSGHLLTADTIFTTPSGLSNWEVNALGEPRSRPKDTNSYSFMWSIPNLIPLSAGEIARMWGILKKYDFKSTHGLFLGQDIEDVNVKKRVLESVRIQLRMMGLKEHPVYSVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNP0</accession>
    <name>A0AAE0JNP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_29603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686307.1">
        <property type="nucleotide sequence ID" value="XM_062823078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNP0"/>
    <dbReference type="GeneID" id="87860232"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="189"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="450"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="530" mass="58377" checksum="8EE6F6C3A3AB84FE" modified="2024-05-29" version="1">MFRSAPATPALKTVRGFHNTPAASGDEDSDYCLSPDPRRGLTTKSSRSTLMVDDVVSANCSPALRPVLSPAMSGISMLRMHQDIQALSLDTSRANTAASSRASSMTSKLGRRVLSGGLVRQNGYKRSNSSGTSSGDETASVATESYEINLEHDFAVDGNVTTTTGSTEAVEIGTDGGVARSQKMTADDFEPLRCLGKGTYGTVLLVKQRTTGRLFAQKQFKKASLVVHKKLVEQTKTERQILESVNRHPFVVKLFYAFQDQEKLYLILEYGQGGELFTHLNTEKMFSEPTAAFYMAEMVLALSHLHTTLGVVYRDLKPENCLLDSEGHLLLTDFGLSKVAVESEECNSMLGTVEYMAPEVIQGKKYGRSVDWWSLGALGFDLMTGNPPFRGGNNAKIQENIVKQKLIMPYFLTAEAKDLLTRLLRKDPAKRLGSNMPKDLDTIKKHRFFRKIDWKKLAAREIEPPIQPMITDPELAENFAPEFTDLSLSPVVSRFEERYAAAAAKDDLFGGFSFVASNSLLDGDGFGMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP38</accession>
    <name>A0AAE0JP38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_35186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686455.1">
        <property type="nucleotide sequence ID" value="XM_062823666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP38"/>
    <dbReference type="GeneID" id="87860820"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="155" mass="17795" checksum="F360D38625376BD0" modified="2024-05-29" version="1">MPVQFAAKRLGKELNKIQNGLPPGIELVSADNLEEWLLDIRVLDNNPLYLNETYRLKFRFSQSYPIEPPEVVFVKQADRPIPIHPHIYSNGIICLDLLGQQGWSPVQSVESVCMSLQSMLTGNTKNERPPGDEEFVRGNKQRPKDIEFYYHDNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPU5</accession>
    <name>A0AAE0JPU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_26690</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686227.1">
        <property type="nucleotide sequence ID" value="XM_062822693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPU5"/>
    <dbReference type="GeneID" id="87859847"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="173"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3354849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="372" mass="40936" checksum="AE28D6524B162671" modified="2024-05-29" version="1">MAPTVLHLRSETKHLEHRSALTPATTAELIKAGYIVNVERSPERIFDDEEFEKVGATLVPEHSWVDAPKEHIIVGLKELEEKDFPLKHVHVSFAHCYKQQAGWETVLARYPRGDGTLLDLEFLVDEHGRRVAAFGFHAGFAGAALALEVWAWQLNHSEPFPGVESYPNEDALIADVQKAVKEGVEKAGRLPRVIVIGARGRCGSGAVSALKKAGIPDENILDWDMAETAKGGPFKEITDSDIFVNCIYLTSKIPNFVNMESLQIPDRQLRVVCDVSADTTSPFTPVPIYTVATTFDKPTVPVDGLASGPPLSVISIDHLPSLLPREASEAFSHDLLPSLLTLNDWQNSPVWARAKKLFDEKVATLPESALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPU8</accession>
    <name>A0AAE0JPU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_505138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686566.1">
        <property type="nucleotide sequence ID" value="XM_062827969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPU8"/>
    <dbReference type="GeneID" id="87865123"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000789">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="113"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="526"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="699" mass="75724" checksum="EEC7590FCB899208" modified="2024-05-29" version="1">MDEDDREYGSSDNEQDELMEDADDAENDTYGEDFNEDDEEEQEEQDEPERDPEPEPEAEPFDESQAQNSHDPNAPDQATSQTARRVSATPSGSGSGAKWRPTIRPEYITASTYDIVPTMAAPQATSINAIAVTPDMRYWLTGGSDGYIRKFDGIGTINGKQQLTVAQKHPFVDSVVKSGVLMSYWDNQEWTGQNTRDDDRILSPVYSLAVHRQALWALSGLESGGINLQSVRHDEGKRIHCLRTNGHTNAVSVLQLAPDEKSVLSGSWDKTVLDWDLNDGSVIRRFEGSGGQISAIELRPTSGAPIPAEASDPEIITDTFESNNSKPVMNGFFSNGANGDMDMTGQASANDGDANDVPSPEHESLFGSPAGSLFGDNETIGGGNAFGDDEDDNEFSRAMGMELKEEQNNQGHTDDFPMGDAEPLTDTNAAQGPGPAANGPAENGTINMDISNGDSSHTMSDFGHQAAAIPEQQNQQQQQPQQDQNPVSQTDHEPIPFEPVAPATPSMVFNTAPSPAPQNDDTQTAPNIFMAASIDGTIRIWDRRVPDPVARIGNRRGVPPWCMGACWSVDGNWIYAGRRNGTVEEFSIHKARGGWQPERTLKFPNGSGAVSCVRPMANGRHIICASHDILRLWDLQGETQATKHSKVPFVVVPGPPKAGVISSLYIDPTSRIMISAAGTRGWDGTSTEVLIGYEISPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ21</accession>
    <name>A0AAE0JQ21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_544808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686939.1">
        <property type="nucleotide sequence ID" value="XM_062829329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ21"/>
    <dbReference type="GeneID" id="87866483"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="141" mass="14969" checksum="A4C41E5934D7FA5F" modified="2024-05-29" version="1">MGPPNGIHGTNETLAPTIRSVLADVVKKVVEEETRQGCSSVVARMLSNADKAWAEYCHRAGIDRDTPLGSPFLPDDGSGEEALRAQKPADRLPARKMLSATATVEDGGSHTAGTGNLVAPLALRPKCNEAQRPAPMMRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ24</accession>
    <name>A0AAE0JQ24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_53700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687010.1">
        <property type="nucleotide sequence ID" value="XM_062829064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ24"/>
    <dbReference type="GeneID" id="87866218"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="158"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="610" mass="66324" checksum="7288C53CDFB0C95B" modified="2024-05-29" version="1">MASTKKFLNHPGAKEAPAHVLEFKPEADHNPPMRGLPLVAASMLVSNSQWLQKFMWSNAKFGQARSMSELNGEQWRVQPNVIPLSSSSETSTQTLLSFDPSLTTPQPPTVPGRFNSIADYHAAYASGQLTPLQVIDALLPLIRRDIKPEQQQSKYAVAFIQSKVGEVLAEAKASTERWQAGRPLGVLDGVPFGVKDDTEVEGYVSTMGMKVDERFEYFKKPATETVWPAKKLREAGAIMVGKMNQHEIGMDTTGCNPTTGTATNWYNTKYFPGGSSSGAGSALSAGLVPIAIGTDAGGSMRIPPAFCGVYGLKPTHNRVVSRNSSMCVVGPMCSNPSDLTIAYRIMAQPNPSDPAQSSLAPSIPPSPTAKKYLGLCPEWIALADADVRTTFNRAIETLCSSPSFGGYELVTIKLPYLREGQLAHAATCLTEAAADARNRVTNPDDYLKPLNYPNRIMVSMGAQTPAADYLRYNQLRQVIMQHLAHLYEQYPGLLIVSPTTPMAGWPIMPGDEAYGCSDGNRSIRNMTYVWYANTSGCPAVTCPGGYVEAQQGEGKLPVGVMAMAEWGEEERLLGFARELERYLAEAYEGGRQRPREWVDVLGAAKGQVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQG3</accession>
    <name>A0AAE0JQG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_585518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687285.1">
        <property type="nucleotide sequence ID" value="XM_062830929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQG3"/>
    <dbReference type="GeneID" id="87868083"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="192" mass="21567" checksum="A4072CAA8EFE617A" modified="2024-05-29" version="1">MCQTTLYKDTHCKHRWMRITTPCFPGAGFTTCPSFSFNNTHTHNNYLYDHHQSPDGLCHQPLCPYQQHPHPNHYTPNHTSPFSPPFSPTLTPSIQAQGQGQLQIQGHNTCHINLPTYPYHQIQHNCPHHQQLVAKPAPPAYIARAEPCPECDLRGVYDRNQVRMVTKIKKGVKLGGGPSGGDPGVEVRCCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQM4</accession>
    <name>A0AAE0JQM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_63086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3356203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="87868460"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="98" mass="10476" checksum="2BFEC860D4F4F70B" modified="2024-05-29" version="1">MRTSPPHTQAHHSHPVFCVSAMRCCEVLLLLLLLLLLLAPQERGSPSEGGVELQHPNLPGPSFTGLFPHFPSSGSSDPQSAPGPIHSRSPTFGQVLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JS53</accession>
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    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
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    <organism evidence="10 11">
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687367.1">
        <property type="nucleotide sequence ID" value="XM_062824125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JS53"/>
    <dbReference type="GeneID" id="87861279"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="189"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="364" mass="39913" checksum="C226AFC480524CC8" modified="2024-05-29" version="1">MPPTKTPDDDIESGQSEATTINEETPLLISQDDDHRAGPDNDTVEDAEQNEGSRYTRSYFAWRIFWAIAAITVTAVFVKAWIDDGADVNFDFKGALKRALGGGISGAAAMVLQVLLLMPLRTIMNYQYRFGTSFTTATKTLYRQGGLRRYYDGMGAALFQGPAARFGDTAANAGIHALLQSNSFLKHLPITIQDIFASLCAAAFRMILTPIDTLKTTLQAQGPRGTAILRQRIKTDGVGSLWWGAFATAAATFVGNYPWYATHDYLLEIIPEPAKHPLGIWLLRLAFAGFVASVVSDSVSNSLRVVKTYRQVNDSKVSYSEAARLVIVNDGIKGLLGRGLKTRILCNGLQGLMFSILWKLFLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJJ4</accession>
    <name>A0AAE0MJJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_583243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677102.1">
        <property type="nucleotide sequence ID" value="XM_062830873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJJ4"/>
    <dbReference type="GeneID" id="87868027"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43800" checksum="52BABECFBFFDB0C8" modified="2024-05-29" version="1">MSKPWILLCPSSRGIGHALTRHLLRTTTLPILATTRTRDPEETKAALLKDLFPYGQQSSPLTDSSSSASDRASAASATGPGVAASSKFSDSSSSDTYPYPSPSEFSSTSADSGESSTSATPDSSPDQFSGHSASSSAASRSTRSSLSDPPKSTPKEDPRLPSASSRLHLLPLDVCHEDSILSCAQQASSLFPPETHHLHLAFALPGILHPEKSPQQVDYDLALDTYRVNCLGPLMLMKHFGGFLPRRGTEMDLSLSWHPVGLGSRTSSGINEEELEGHHHHPLERMLLLPPHATWINMSARVGSVSDNKSGGWYSYRSSKAAVNSLTKSFDHQLQSRSGKKAMCIGYHPGTVRTDLSKGFWESVRNDKIWEPEEAAGHMAGVIEALGEQQRGRIWDWKGEEVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJK4</accession>
    <name>A0AAE0MJK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_553279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="1"/>
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            <begin position="62"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 560.94</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAK3334655.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
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                <person name="LaButti K."/>
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                <person name="Lipzen A."/>
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                <person name="Yan M."/>
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                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJT7"/>
    <dbReference type="GeneID" id="87867471"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MMQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C-type lectin protein</fullName>
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    </protein>
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    <organism evidence="11 12">
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677732.1">
        <property type="nucleotide sequence ID" value="XM_062823379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMQ7"/>
    <dbReference type="SMR" id="A0AAE0MMQ7"/>
    <dbReference type="GeneID" id="87860533"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="9">
        <location>
            <begin position="63"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="10">
        <location>
            <begin position="393"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="8">
        <location>
            <begin position="571"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="8">
        <location>
            <begin position="782"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="727"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3338281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="887" mass="100062" checksum="585C4840F03A6166" modified="2024-05-29" version="1">MPSAETMASTPNGALGQLKITGKHVLSKLQQQTSNADIIDIRRVAVEINLKTEITSMFRPKDGPRQLPTLLLYNERGLQLFERITYLEEYYLTNDEIEILTKHATEMASFIPSGAMVIELGSGNLRKVNLLLQALDNTGKEINYYALDLSREELERTLAQVPSYKHVKCHGLLGTYDDGRDWLKAPKNINRQKCILHLGSSIGNFNRSDAAAFLKGFTDVLGPNDKMLIGVDACNDPARVYHAYNDKEGITHEFILNGLRNANEILGETAFIEGDWRVIGEYVYDEEGGRHQAFYAPIRDTMVMGELIRSHDRIQVEQSLKYSKEEAERLWSKAGLEQVTEWTYGNEYGLHLLAKSRMSFSLIPSVYARSALPTLDDWEALWATWDVVTRQMLPQEELLEKPIKLRNACIFYLGHIPTFLDIQLTKTTEQAPSEPAYFYKIFERGIDPDVDNPELCHAHSEIPDEWPPVEEILTYQETVRSRLRGLYAGGIENIPRNVGRAIWVGFEHELMHIETLLYMMLQSDKTLPPTHIPRPDFEKLARKAESERVPNQWFKIPAQEITLGLDDPEDGTDVNTHYGWDNEKPVRRVQVAAFQAQGRPITNEEYAQYLINKNISKLPVSWAGLDDENLTNGTRNGVNGHHRNGASKQLPSSFLEKTAVRTIYGLVPLKHALDWPVFASYDELAGCAAYMGGRIPTFEETRSIYAYAEALKKKKEAEKQLGRTVPAVNAHLTNNGVEITPPSSPSSETPSESPSSPSSSSSSDNTTITTTTEDLFADLDGANVGFHNWHPVPVTSSKPDTLLLGQAELGGVWEWTSSVLGKWEGFKPMELYPGYTADFFDEKHNIVLGGSWATHPRIAGRKSFVNWYQRNYPYAWVGARVVRDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN39</accession>
    <name>A0AAE0MN39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_445063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678137.1">
        <property type="nucleotide sequence ID" value="XM_062825712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN39"/>
    <dbReference type="GeneID" id="87862866"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="410" mass="45473" checksum="46DB421CBC46CEEF" modified="2024-05-29" version="1">MADNTNIEALIESRIEAAISAVQDLPQLLEEAAENNSVVLLDMWYKILIHMYNNLVSPTGTLRSLNEIEFTMVSDQERPRYSDFIKLAHRWLVAMHCAGVGEQAFANLAQYKPRLNAEVLEVLAPHELEQCEKRSNMRKVVDQEYPGHIKSEAEFRLRKGALMTTTVYETEDSEVANISHTEEEKIEFVKKLVKAMANMTGIADKANHHHVQAVKAISGSVVEELGWEFYVYAREAQQGRTWVLPWNTSFTWQSYATFEDRWADIVDFFHECKSAVANALQATYIQRYTSDPHREHTRPGGGKFPSCSTAARDSGRCRCFRPDPYGWALTAVANSAEGINIAPVDQVAMSPNVAPAVAPEVAAITSPSEASIDGNFPAAPPNSPIMNPTALAPGVAGVRSADDPQDGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN71</accession>
    <name>A0AAE0MN71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_305849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677299.1">
        <property type="nucleotide sequence ID" value="XM_062823211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN71"/>
    <dbReference type="GeneID" id="87860365"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3337848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="124" mass="13900" checksum="08EE9A91AF4A2890" modified="2024-05-29" version="1">MGVFFRFWASLHGRGETLSLLFLFSQNSSQTLPFGRGSTYLRSETRMLQHRGMHPCHVVPVVQFLHMAFGPLTIGAVPDCKSMQWYAVAEPAPGEPLHAAYSHAAQRPESGVRPVRGILYMWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNS0</accession>
    <name>A0AAE0MNS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_476285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678738.1">
        <property type="nucleotide sequence ID" value="XM_062827355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNS0"/>
    <dbReference type="GeneID" id="87864509"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="251"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="564"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3339378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="814" mass="89392" checksum="924E9D47A44FA11F" modified="2024-05-29" version="1">MGTKSLEFKVRKLQANSTTEKDLAKKQPSRVYVNEEALLELTGSKDGGRAITIEKIDKNSSDDQPVRREATLWKSPERIDKASIQLYDAFRDVCGYQTGVQVKVTVQEGKLPEAEEVVLEQLPPEKAGKDAETAGPIDPSEIPGWEFFLSGRLSMIEHVHAGLTFKNLYARGPQRSFVVASVNGRPTGNARYLDGKTKVRIGAPSPAGQADGVRQGKLEVTGVRGLDTQIEKLNDLLSQFTDPWVFKGKPRYRGIVIHGGHGTGKSMLLNTIAATGWGTVYRIQPKDKLAEIQDMFQKARLEQPSIILIDQLERLIDKERNNRTSVIQALCEALDTLGADAQESGEIPKVAVIVTCLDYTTDVPEDLKDPGRLTGEIYLPLPDVDGRKEILASFNLRVASEEEDALLRSLSERTHAYNGKDLRRLVDEAEFIARTRINRTAKKTTTPPSTEDLVSLNDQPAAATEEVASLMNSLQLSDANANASTTTTLVADSITSPTEYFLPADYEEALRLVRPSAMHDVNLKPPPIHWSDIGGQASVKVSLRRAVRMSTEPVHVLSRFFARPPKGFLLYGPPGCSKTMAAQAMATESGLNFFAVKGAELLNMYVGESERAVRRLFQRAREVAPSMIFFDEIDSIAGQRSGFGHGGSSTSSGSGGSSSGLNVLTTLLNEMDGFEALTGVVVLAATNRPQALDPALLRPGRFDELIYVSPPDEEARAAIFGKEAEKRQMLIGEEEIERLATITDGFSGAEIKGICAVAGTRAYDRYLKLDSVEEDTPVGITIEDLEMAAKGMMRQITPEMIRGFEQWEKQFRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNT9</accession>
    <name>A0AAE0MNT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_476526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678798.1">
        <property type="nucleotide sequence ID" value="XM_062827368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNT9"/>
    <dbReference type="GeneID" id="87864522"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="64" mass="7274" checksum="EB7A39D769995FEC" modified="2024-05-29" version="1">MSSPSTTTSRRNIRPHEAIDDLESLYKGPSPSFIAREFDLSRLHSIRHLLWLAGRPYGEEAGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNZ5</accession>
    <name>A0AAE0MNZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_304562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678963.1">
        <property type="nucleotide sequence ID" value="XM_062823197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNZ5"/>
    <dbReference type="GeneID" id="87860351"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="133"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3339603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="634" mass="68549" checksum="410F32215777A5F3" modified="2024-05-29" version="1">MAPSGGASKRDDDARSGLLSDNNNNSGGRGDSKAAMTGVVNYHTINNNRYVDSPRSSADLTYLDPEPLYDSSDNDDTMGSSSSSSSSPILESQQHLPRARRQGGDQDGSPDDSADLLTTTESRSLTRGLAQRHLSMLGIAGSIGTGLFLGLGGAVARGGPLGALLGYFIIGLIVCAVQFALGEVASLLPVTGSFVRHAEFLVDPAWGFAIGWNLVYGNVLSIPSEITAICVLFEYWTEGRISPAVFIVFFVVVTVGMGMALVRVFGEVEFVFALLKVVLVVFLIVLGLVIDLGGIPGTERIGFRYWKSPGPFVEYIATGDWGRFLGFWSVMTGAVFSFAGVESLAMAAAETRNPRKAIPRACKRVFARVVLFYMLAVLVVGMLVASDDPRLDGSGDSVAQSPFVIAASAAGIKAIPSVVNAIVITSAWSASNQSLLAGTRVLYGLALKGQAPKIFLRTTSWGTPYMCVLLFGVFMSLSFMSLSERAINVFWWLVRLTSAGVLVSWSSILVNHIRLRKAMDRQGIAYTRLPWSSWWTVYSSPVALFMCIIILLTGGFSVFTKGNWDAATFVSSYLDIPIVLIAYLAWKLYKKTKVVSLDDIPLDIAFKQAEDAIFEEPEEGKTKGWVRAVSWIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNZ8</accession>
    <name>A0AAE0MNZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_445081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678154.1">
        <property type="nucleotide sequence ID" value="XM_062825714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNZ8"/>
    <dbReference type="GeneID" id="87862868"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="434" mass="49922" checksum="DC93338A443ECDD6" modified="2024-05-29" version="1">MDVKVATEVAENFPAWEHKLNFLKTSVGKTYQELEVDRDKLERERLARERTRRREEARKAEERHKQIEEEEEKIKKATKEHRRREEEAKQEEAAKKAEEAARGKTFLASQTTVAYLSTHPASGSAHARRMLLISDPVALYPVVFRWYTSHIAQLPAFIAMIDAIAEASRASKQRHHQEILQKEAEERVSLQSQRTLQNKVMQWRFKDKEQLYANHDKEMLNMVNDNGIMKAQVLSPGFQAPPHEPPMDTLPTLSFEDKVLVSNLPKIMKNANPETRAIYWKIIDEMFQSVRNIQAEYVGQDPSESMYPPVSHYTATISHAEHVSTLVMKNTDFTDRTNPPQTDADGDAGQGKKRSRNDNDSMDGDDYLERQSRAPKKARLQQGAIVQQAEFAPQEDFEQPTIVQQAELAQPGHFDHQDMELPMPGFAQKGQFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNZ9</accession>
    <name>A0AAE0MNZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_405498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677555.1">
        <property type="nucleotide sequence ID" value="XM_062823807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNZ9"/>
    <dbReference type="GeneID" id="87860961"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="52" mass="5710" checksum="3431B6666678F714" modified="2024-05-29" version="1" fragment="single">VTTSTTEAEFTNLVPTAKALDWICGMLDDLNVDLGLHKVNRILYTDSSNAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP56</accession>
    <name>A0AAE0MP56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_286091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678334.1">
        <property type="nucleotide sequence ID" value="XM_062822948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP56"/>
    <dbReference type="GeneID" id="87860102"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="105" mass="11822" checksum="5C1E24D25D16A73D" modified="2024-05-29" version="1">MIPLPVVHLLKFSKLGLASGISAVFLGVFFFFFSFSQGHDGVDEKTWMNDINDGIRTYFFRTLLGSRALLCAILRDFGRGPGAQRQIRFYIHSGTHVHTDGVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPA2</accession>
    <name>A0AAE0MPA2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_433080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678484.1">
        <property type="nucleotide sequence ID" value="XM_062825041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPA2"/>
    <dbReference type="GeneID" id="87862195"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="259" mass="28701" checksum="2345BBB17BA24A32" modified="2024-05-29" version="1">MGSSDQSPSLPALATNPKFIFFTDFDGTITQQDSNDFMTDNLGFGPELRKRGNDDVLFGRRDFRDSFQEMLDSIHTPLDQCIETLLQNINLDPGFKEFFHWAKENNMPIVILSGGMEPVIRALLAHFLGKEEADSLQIVSNQVAVREGKQSVNEEGGWMITFHDDSGFGHDKSLAIRPYANLPADQRPVLFYAGDGVSDLSAAKETDLLFAKAGKDLITYCEKEGVPFRTFHDFFDILAVVKDIAAGKLTVKEAAVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPJ4</accession>
    <name>A0AAE0MPJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_430326</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679548.1">
        <property type="nucleotide sequence ID" value="XM_062824874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPJ4"/>
    <dbReference type="GeneID" id="87862028"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="333"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="537"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="737"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="813"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="683"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="758"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3340606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="842" mass="93295" checksum="3733EE8333BBC583" modified="2024-05-29" version="1">MAPSQKRKAIDDDFILTISDNEDNIPLEEEQEVVPRKKAKTAEQSNKQKKKNNKKSKKQQQTEDDDDEAAETKEDDAADLGIWGSKDEDDGAMDTEFQFVVDGQNEVDAEFDGWGFEGAHKGGVKGAGANGDKKPVDIDEIIRRRRERKAAKEGKTTTASKEEDKMEVDGDDEEEEDDMEEIDVDLDDDEEGVLADDAFGMGVGSDVEEEEEEKQDAKMGGVDGEDEEDSEGEEGEKKEGSDEEEEGDASDDDSVATAVEHPDDVQSSDDDEEGIDEEEEAKMKEFFAPEEENQPKKKGEMSSFQEMSLSRPILRGLTSVGFTKPTPIQAKTIPISLMGKDVVGGAVTGSGKTAAFVVPILERLLYRPKKVPTTRVVILTPTRELAIQCHAVAVKLASHTDIKFCLAVGGLSLKVQEAELRLRPDVVIATPGRFIDHMRNSASFAVDTIEILVLDEADRMLEDGFADELNEILTTLPKSRQTMLFSATMTSTVDKLIRAGLNKPVRIMADSQKKTAGTLVQEFVRLRPGRESKREGYLLHICKTLYTERVIIFFRQKKIAHKMRIIFGLFGLSCAELHGSMNQAQRIQSVEDFRDGKVNFLLATDLASRGLDIKGVDTVINYEAPQTPEIYVHRVGRTARAGRSGTAITLAAEPDRKVVKAAVKSGKSQGAKISSRIIDSAVADKWQAEIDDLEDEIEEIMQEEKEEKQLQNMEMQVKKGENMIKYEDEISSRPKRTWFETQEDKKKAKAAGRAELNGVRDKLKSKNEGKLSNKDRKKLDTMAERKQERTYKKGSAERAGKGAVLNLKKVVKKAGVKKVGRSAGPKKKGGNGARGGKGKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPU6</accession>
    <name>A0AAE0MPU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_433203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678455.1">
        <property type="nucleotide sequence ID" value="XM_062825049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPU6"/>
    <dbReference type="GeneID" id="87862203"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="55"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="487" mass="53907" checksum="711E141A6E6D48F5" modified="2024-05-29" version="1">MHGSRYSSEAYVLYRSEDENTTPPPRGYRINEDYGPSMLGAIWTTWSIAVIFVALRFWARSRVVNGLGASDWCILFSLSAKPNEVTEIAHGMGKHLWNVDYKADYVPLMAGFWASALAYFSSLAMTKISICLLYLTIFTVESARRATYAVFVIVCVTSVYTIIVICTACVPLRDYWDPLQPWGLGLPKPNCHTNQWYWSCTGMTIITDFLIFLLPIPIVGPLKLPARQKFFVIGIFAVGFVICIISLVRVFYLYASQDISQKDITFSTGKLNYWTALEVHTAIVIACVMTLKPLIVRFFPGFLDPRANNSSGEQGATGEPTAASSEPPLTVGRRPCRNAFGQRLSVIEVPETSEQQQQSGPGPTTTATATWDVALSEIPVSGRERYHQFLHPSFPLAAGRTSSDSRPSYEMKTTTTTTMTTTNYNTTTTSAESMKANSDTTSVTASYREEDLDSTANLKGFVHVQSDAVSVHTGDRELGPEHAVRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPY3</accession>
    <name>A0AAE0MPY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_591082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
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    </reference>
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Mondo S."/>
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                <person name="Yanf M."/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Labutti K."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Gladieux P."/>
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                <person name="Johannesson H."/>
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        </source>
    </evidence>
    <sequence length="1119" mass="119713" checksum="05E339F8875F934D" modified="2024-05-29" version="1">MDIYRAYELHFRLSKEVDDLEKELEAEKQNASRELQKAKNEIEDRRLEERLMLQKSLGTIPPNLGQFIEDKRDFYLRQATQNYEARLENDRKRFVEKVSAVNEKWRTLPFDIEDTSTPFTELPLSRLSLPLGTKAPELSNGTRTPGMPMPMPSSTQKPLPPTQLAPRAHPAAGFPVFNPSNLLPKPPTAVPAASVQKTVPASSTSKRPITETQSPNEMIANEQQPAKRPSTKRSITFTEVYQDGNAKFKHIIVEYPPESGEFYILKCDDHGVHFGANPLAGAAKHLASRMHDHQSKNYSVAIDTLGFRVIGCNAELARMNNTAVEEAAVNGYRPVNLLQLSVGKRARYVEANPEFANSFPTPIPPLASPAAEALVPAMAPPSLQETASPAMAPPSLRETASPAMAPPPLRDPSTPSPAKDRRKSLHVRTPSDRSTRSAVLIPDPKPASLYKGFWVQDKRHYPVMVLPVKEADLSSVGLQKTLEDIKLLQNVPLCYKLGKIAGGKIKFEGWAPGYEDGGPLVKLRQVPVMYFDRDMSFGWLSIKDISAFDFDDPDWRQIPYFQKAVEHWESLNKVGADGAQEPRLEPIPATLPEPARNPAAPAAAAAPTASMAPTASMASTASTGPTAASSGPQSVPAAVPQPTQKPAIPAAAVAPKPAPPRPQPVSAAVSKPPAAVVAPPRAAPSRPQPASVAVSKPPTVVVAPPTAAPSQPQTAAATVTKPTRTPAAPTAVMPPTLASSRPQPVSAAVPKSPAAAVTPPTAAATPTMSKPVAPSTVSVPIQSGPNGIPPAVVRLAEIAKTDPQLRALIERVSSKQGTKEENERLESIVDRIALELSSSGEAVAATVQLLQPNSVTSDPKNATARAAAFGAPASRPPSLAAPSLKEGKKGHGTGLKSPESSKPPTPQLSKAAIPAAAAPSPLVTAGPTPDSSKASSRTTSPTEAPTSTPINNPPAKPATFVKPENGVTTTPPTTKTTQPQNEKFEVSIEKGSWNVETKCPMEDNLSVRLIACNQTKIASTAPGMAYKYCPYKFEIDPNNFASVVVENCPSNPNAKTIVTMILKKEREGSGDRTVVLTFDRFVNPDTKAVESGRVQARRFCRWLRGVNTSIAYSNKRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQU8</accession>
    <name>A0AAE0MQU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_229884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680571.1">
        <property type="nucleotide sequence ID" value="XM_062822164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQU8"/>
    <dbReference type="GeneID" id="87859318"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="3">
        <location>
            <begin position="138"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="807"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="924" mass="100158" checksum="1853AE1DACF85CC3" modified="2024-05-29" version="1">MDNLTPPPTLNGDVPDQEGHCTNSQCTRDRGILEGLNNTLRAEKAALETENTELRAEIARLRARSSKHTQRTWPRMLRQYLLTGDPSWDEVCRQCNKEENMSVNVKWHHPDIKFVTPEEGDAAVPDLLGPVDNRQFNFNALPVEVQARIFRLWLYKEGNLIHAISRLDPFVPNEDFPEEAALRKRSGLKHTFFYGERNCSITHSGQPPNSLLRILLVCRRFYFIGIHCFYGLNTFAFSSLGEFLRFCQGIGPARVDRLQHLEITLTGNQYLTVPLDEKGRIPYSRRTFPLSFLPDCHRLRTLVIHVDESSSHYSRRRYETRAIKEFMDGKTAGQPNQRKLRALRCIQGIDFIYALRGLEWIRFYDLHKAIISGTATREPVADWSFVEDVTNTATMQKVASRRESSKLENLQPLFSNNDHQQEAWNPGRADWELVKSFYIDNGGIRSYDQLRQDGFPHDADILSRMSASSGPRQGHSSNSGSSSSSSSSSSGGPHHGRGGPAIRGRGDRGKAAAARRGQVARGNASRGRGGQGASGRGRGGCFANVNVNAARSNPTPSPSIPVDHDTSMSSGSSDSDSDSDDSQGMAMSAAGGSIADAIDLSDSDSDTETDSPHTGSAAGSILIELLSDSESDSEEDSLFVSQHNHNHHHHHRDPSRSRHGSSSTGDAATPMLIDDDADDGDHHHNHHHHQAPSTTASVPVRLHSLTPMGFMTPSLMDRGISVPANLPFLGPPSFASLLNIQPASAAGARYLPPNNAAALESAAAGVAASRRGSMSMSMSMSRSVSRSVSRAGSFASANGGGSGSGSRAGTASSCGRSLARLSVRSGSSGSSGSSGLFVSQRQRQRQSGGTSERDSVDLTNADEDDEHAEDDEHGTSGGSGSGHGDGELMTIEEEKGDENGNDREGQDSGYEGADDSDVEMVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQV1</accession>
    <name>A0AAE0MQV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_428455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680897.1">
        <property type="nucleotide sequence ID" value="XM_062824762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQV1"/>
    <dbReference type="GeneID" id="87861916"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3343104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="110" mass="13275" checksum="EF09FF2878987D95" modified="2024-05-29" version="1">MCYFEQTLWSCGYWKWGNFRQQCNKEYRTGETCGLKLVYETNFIPSPCKICEQITKKDRRVRKMAEDIARWRREGNRMATIEKTEQDIAGVRSQIQDLWRGHEEKQRSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR74</accession>
    <name>A0AAE0MR74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_540654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680931.1">
        <property type="nucleotide sequence ID" value="XM_062829159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR74"/>
    <dbReference type="GeneID" id="87866313"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134:SF9">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
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        <property type="entry name" value="ANK_REPEAT"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="431"/>
            <end position="476"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="460"/>
            <end position="471"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3343138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="624" mass="69267" checksum="D0755422974BFE4D" modified="2024-05-29" version="1">MDENEQSQHENETSKALAHALRTGDLATILRLLNSSQHPISPTTICISPNFPAGNPLSCTELVQCHPLGVASMFSHPKLVSHLLSIPQVLTHIDDPVSNLCKCLYDPVDTRALVDPDVWHDPAHWTALHLAICQGKEEEYENPPIILPNREPSLRIVKDLIKAGASLTGSADQPHQEKITILHTAALKGRVDILSYVLSPEFSRKAEVDINARDRKGRTPLHYAALRYSPSPDDDEKDLSCIRYLLYMGADRESRDIYSQTPFTLALSFGCFSSAKILFLKGAKHDFRFLFPHTYTLSFPLQVLAHSYETFFNSPSRPGPVAKPTWEAQRADLIKTITRLSPPGVTSVDCGCFYADNIDPDEQEVLHPLHIAAGDGSNPTSVLSLFLDAYAGPQSRSGSRGTWTTALHEAVRSQPPSERLRWSMVHPDYDPESGQIARFGEEPEPPAAASFVNPPPPSSPSRSNSTSSAITEESEERGIWKIGAKPRINTPAQLHQWTAILKCVVLITRGAKLCKTNSEGLTALDLAIRRSEGEESIYRIDEQGGQQYKYCSYKFVGSLLFNLILPFKNPPQPLLDVEDRMYLAEKLREVIVANPQLAFELVAAGVDLVVVKERRHEIHRTACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRH9</accession>
    <name>A0AAE0MRH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septation initiation network scaffold protein cdc11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_181459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87858666"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
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    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
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        <property type="entry name" value="LRR_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
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    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <end position="741"/>
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    </feature>
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        <location>
            <begin position="1164"/>
            <end position="1175"/>
        </location>
    </feature>
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        </location>
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            <end position="1338"/>
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        <location>
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            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1956"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1979"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2138"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="2169"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
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            <end position="2218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2233"/>
            <end position="2255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2255" mass="247402" checksum="7D423247234016C7" modified="2024-05-29" version="1">MGHAWLDSLSEDWPSQPGSLASNASQFANKLDSHQRSQSQSQSISRPGTATSQSRKPPKTPPSRIPRPNSNRTSANNSILHDDRVNSNTASNAASRRGSTKSLGDRVRDRQRAIDARSRTASIAESVQSGGSVIHNMNGYDSPGRKQDTPEWKRRLVYRELDYGEAPDLFTSAGAILESIFKPPPPPAATTMADTNPNSNARNGRGFESQYESQAESHVEITLPSSPPFLGRERDPSTVEIHVEESLQSLPPIPKEPEEEVEEGQQEQQRRKIPEIRYRRATDSSAPSQGSESSFRASTTQQQTYPKVRSRTPSTSASSHLGNLSAGSRQASGQSVLRHEDFSPILLTMHDAGDGNSSFAPEISPDELRYRLETLRKNQLRMARTGRSDSGASVSGKSESGKSEADAAATGGSSRSDNKAGDTNNTSKDYEKLGSYINVRRGGRSADGSFQNHMLSSALNDISELNPEESLQASTPKRFPSVRVEHWDDYEHVPAQVSGNISDEISPRSRPAFPRIPNLSAATKRVPSSQQGAGSPLKLFQPYDTFTSEILQRRLSQYHNDTPGEQASSGQQTGDESPVNISYMDSGGYLSPPKTHTRRGQETGQRKASVAVNHFGAGVLDGYEFQDEFSYQSVGASGVEGDKENQGPNDDSLPGPPIPVFDFSRPSSHSEADADADADADASNSSVRRKRQKPVDSGSSKRHSKTGSSSAHKKRHAFTHIPATFATPSKRRTDPAPEFKRPRTSPSKDPTPKRRRTLHESDIEFGLEDLSPSPETQSMKLSYQQIQATIDKRRKEVHAEKRREPVEPGTPSGKDVPRPSTPTPLQRSSLQKEGKKGRPPLTELITKSSSRPTRPSSKASSKGRTPKKHGAPGSAMNTDRKPSIKTEDFLIEANKIMAMIRKNAASGLTSVEESDEYDSRHDADGESSYEESTQESFLRPPSREGRPPLTRRSTKQEDPVLAERLKQYEEASDMGDIMGSSLRSAALYRQGFGTVRQDEKHHAGKKGGPVLPDFREDGVISDPPNIRISWNPALKTKLSHENVEDGRHTQSESDNYTGRSSHTTSSKGSDTRKTIAPESVLHLIPDRVGNMVLDRERNVWVRKRPSNGFMGSRQNSFIASEVSEDDPFADIPDLTVDITEELEKLRLTTNQRGQEHEQEHEQEQEQEQGDLDLDQPSDVAAPFGDDDFLNSEPQWQPTGSRRDSDTSNPGKKNKPTSTDEQRDAKPSLQSQKNTGTGTSTGVDVEHEIGIYEDRVSNTPQAARRRQLTISFSSPIASIIQDIQDVADDVDSDADAPSALGLTGGEGNNKQQRKRSLPPLPPRGYTKQQQQQQPQQPQPRGRRAVSISASKLRNEVASGSASRSRSRSRGPPRHLSVKGQTYMARPVSRIDEHDEESSNANKNSLRFHGHDQPSLLSPQPQGMELSIVAAETSMVNQEDHEAQHNNSISFLVATPAHHLRPCSMSGTDPAHIISQYVGTFSLSPLSDFTIHPPDESSLALEASYVIGNHHLVTGDHHSRGRSMSMSTRDLVAKLTEVEPFEPYWEDMRNLCLAHKRLESLHALDAFCGRLESLDASHNEIRNLTGAPSTTRFLKMINNQLSSLTAWGHLINLQYVDISNNRLTSLNPFKQLVHLRELRVDNNRLESLEGIKFHDGLQVLRARGNCIEEVDFDGARLVHLTELDLRGNKIKTVVNLDQLPVLSSLNLEGNQIDVFEVGSPAAITSGPNSPVSEHGQAVSSLRYLHLNDNCLSHLSIHALPHLRLLHADRNRLVRIHGFSRARHLDSLSLREQQGPEPLDLDHLLSRAYEVRKLFLSGNYLGSTTNPKGVEESGFNPRIDLLNLQLLELANCGLTKLPVDVGQMMPNLRVLNLNMNALEDLSPLRHVPRLKRLFLSGNRIRDLSSLVEVLTNFSCLTAVDLRGNGLVMGFYSPVQELCKGGAASLGKQNQNKSSNNMDEEAHAQKGQEADDGQQDEHENKDQWTLPSQTPASDKAYSSRLDLQTKMRRRVYDHLLAEKCSRLKKVDGLPFDRQDVLGRRDEVWKALVARGVFSIPSSTPVHAATGPATAAPANNMSGVPNVPGMPGLPTGASSFGSAVGGFGFGSPTTVVGSDAEGPNGQGGHGGGRRQSMSPVAGRVNGQSQSQSQYQQQYQQQYQQQQQVLHNGSPLNGRGRGVNGVNGLSGGGNGVLREVDINANGGMGGHGVNGCPPSGGMGHGQGSGMQQIQMSGMGMNQREMEERVRQMQREREERWLAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRV1</accession>
    <name>A0AAE0MRV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_465190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681606.1">
        <property type="nucleotide sequence ID" value="XM_062826798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRV1"/>
    <dbReference type="GeneID" id="87863952"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="107" mass="12117" checksum="7ADB42CB530EAC01" modified="2024-05-29" version="1">MVLVSVEGPGRETREEDLCSSALESLMEDLVMDPENGLYRCCCCCPAEPCRGQIDGDRQLLVCHHYHHFSFSFLTIVPGGPFRSRCHRLVPPFTFTASLEHPSWFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS06</accession>
    <name>A0AAE0MS06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_427229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681771.1">
        <property type="nucleotide sequence ID" value="XM_062824674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS06"/>
    <dbReference type="GeneID" id="87861828"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000041">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3345158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="395" mass="42456" checksum="4BA0E87097380B8F" modified="2024-05-29" version="1">MASSQHVLLSPAELAYLHASLSLTPPIRPDGRSPTQFRPLVAETGILPGTNGSARICFADGTEAIVGVKAEVERTRTRHDFPSLDLDEGAEDDDDLDDNQRDVVKGDNDWVEMTVEIPGYRDDDAGTVFLSAMLSEALLADGEFTKRLWINRRFHWKLYLDILLISPPLSYPLPLLSLTTHLALLATRLPRLKSEGDEDPLFDDDWAAAPYLYPRPTGKKGSKKAASAPTARPPVTLLVMAVGNNIIFDPSKEELAVADVALAVSVGESSSSSSTTSTSSSKPTAMDLDTEETKGHNLRLLSVRTIDPPSRLTPPGIPNASNSAYGANAGAKDTEKKKQQQEQARTAESEAVEGVWKAPRGGAKPLVMAALVQKVLEKGGVADEVLDALDGVDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS42</accession>
    <name>A0AAE0MS42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Plasma membrane ATPase</fullName>
            <ecNumber evidence="4 18">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_426022</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cell membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="4 18"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681876.1">
        <property type="nucleotide sequence ID" value="XM_062824612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS42"/>
    <dbReference type="GeneID" id="87861766"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 18" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3345263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="923" mass="100174" checksum="625B1771F652D5E4" modified="2024-05-29" version="1">MADHSASGAPALSTNIESGKFDEKAAEQGAPYQPKPKVEDDDEDEDIDALIEDLESHDGNDVEEEEEEGTPAGGGRVVPEDMLQTDTRVGLTSEEVVQRRRKYGLNQMKEEKENHFLKFLGFFVGPIQFVMEGAAVLAAGLEDWVDFGVICGLLLLNAAVGFVQEFQAGSIVDELKKTLALKAVVLRDGTLKEIEAPEVVPGDILQVEEGTIIPADGRIVTDDAFLQVDQSALTGESLAVDKHKGDNVFASSAVKRGEAFVVITSTGDNTFVGRAAALVNAASGGTGHFTEVLNGIGTILLILVIFTLLIVWVSSFYRSNPIVQILEFTLAITIIGVPVGLPAVVTTTMAVGAAYLAKKKAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHDPYTVAGVDPEDLMLTACLAASRKKKGIDAIDKAFLKSLKFYPRAKSVLSKYKVIQFHPFDPVSKKVVAVVESPQGERITCVKGAPLFVLKTVEEDHPIPEEVDQAYKNKVAEFATRGFRSLGVARKRGEGSWEILGIMPCMDPPRHDTYKTVCEAKTLGLSIKMLTGDAVGIARETSRQLGLGTNIYNAERLGLGGGGDMPGSEVYDFVEAADGFAEVFPQHKYNVVEILQQRGYLVAMTGDGVNDAPSLKKADTGIAVEGASDAARSAADIVFLAPGLGAIIDALKTSRQIFHRMYAYVVYRIALSIHLEIFLGLWIAILNRSLNIELVVFIAIFADVATLAIAYDNAPYSQTPVKWNLPKLWGMSVLLGVVLAIGTWITVTTMYAQGENGGIVQNFGNMDEVLFLQISLTENWLIFITRANGPFWSSIPSWQLSGAIFLVDILATCFTIWGWFEHSDTSIVAVVRIWIFSFGIFCIMGGVYYILQDSVGFDNLMHGKSPKGNQKQRSLEDFVVSLQRVSTQHEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTL0</accession>
    <name>A0AAE0MTL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_423391</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683376.1">
        <property type="nucleotide sequence ID" value="XM_062824452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTL0"/>
    <dbReference type="GeneID" id="87861606"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="6"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="87"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3348294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="519" mass="56883" checksum="AE6F454EC73692CC" modified="2024-05-29" version="1">MAPAHKACLIVIDGWGIPSEESPKNGDAIAAAETPVMDELSKSATGFTELDASSLAVGLPEGLMGNSEVGHLNIGAGRVVWQDVVRIDQTIKKGELGQNDVIKATFERAKNGNGRLHLCGLVSHGGVHAKQTHLYALLKAAKEAGVPKVYIHFFGDGRDTDPKSGAGYMQELLDTIKEIGIGELATVVGRYYAMDRDKRWERVEVALKGLYLGEGEESTDPVQTVKERYEKGENDEFLKPIIVGGDERRIKEDDTVFFFNYRSDRVRQITQLMGDVDRSPLPDFPFPNIKLVTMTQYKADYPFEVAFKPQVMDNVLAEWLGKQGVKQVHIAETEKYAHVTFFFNGGVEKVFPLETRDESQDLVPSNKSVATYDKAPEMSADGVANQVVKRMGEQEFPFVMNNFAPPDMVGHTGVYEAAIVGCAATDKAIGKILEGCKKEGYILFITSDHGNAEEMKFPDGKPKTSHTTNKVPFIMANAPEGWSLKKEDGVLGDVAPTILAAMGLPQPEEMTGQNLLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTW2</accession>
    <name>A0AAE0MTW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_456414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684228.1">
        <property type="nucleotide sequence ID" value="XM_062826291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTW2"/>
    <dbReference type="GeneID" id="87863445"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="271"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3350933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="361" mass="38602" checksum="3DF110BF7EF94FE6" modified="2024-05-29" version="1">MASRPTVTIIGADGKATGATEVLPKVFGAPIRPDIVKNVHTGMAKNKRQPYSVSEKAGHQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNMCRSGRMFAPTKIWRKWHVKVNQGQKRFATASALAASAAAPLLMARGHQVATVPEVPLVVDSAAFSGVNKTANALALLKAVGAGADVEKAKASKKLRAGKGKLRGRRHRQRRGPLVVYSAETDGKDLVQGFRNIAGVETSPVDALNLLQLAPGGHLGRFIVWTSAAIKELDAVYESKKGFQLPANVVAQADLTRLINSSEIQSVLRAPKGDAKTKRTNVQKKNPLRNKQVLLRLNPYAATFAKEKLGEIKEEGKPQRVPATFKALLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTX0</accession>
    <name>A0AAE0MTX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_547417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682685.1">
        <property type="nucleotide sequence ID" value="XM_062829517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTX0"/>
    <dbReference type="GeneID" id="87866671"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="220" mass="25369" checksum="5DB68C992946C9F8" modified="2024-05-29" version="1">MATAFQRWLSPRPPQRTKNNDKPSWSHLGDAALYEPLSKPDGLWYIRETHHMENYFVRAGLSGPPLHIHRLQDEFFKVEQGVLGVVKNGVEYAITKDDGVFPIPRGTRHRFWAHKTGTEDLVFSIWLDPCTSKKEHILDVNFLRNLSGYVNDCLKAGLQPSVLQIILFTENASSLLCPPFLNWMPTPMLFWAHRGIAWYAESILGYERSYPEYIRDSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU85</accession>
    <name>A0AAE0MU85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apoptosis-inducing factor-like mitochondrion-associated inducer of death 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_160948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683045.1">
        <property type="nucleotide sequence ID" value="XM_062821237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU85"/>
    <dbReference type="GeneID" id="87858391"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="433" mass="46891" checksum="811ECE10F9BCFC83" modified="2024-05-29" version="1">MGSIAIDDATMSRPPFKVLVVGGSYGGLSAALNLQDICSGRAARCGPDAKKATLDGTSAAHDGPHFAVDITVVDERDGFYHLIGTPLAFADESYAEKCWVKYEDVPALQQSPNNIRILRGSVQSIDQERKVAKVLGSESGPEPTELEYDYLIAAAGLRRVFPVVPQSLLRKQYLFEAGDHIQAATANRHGVAVVGGGAVGIEMAAELKLVCPDLKVTLIHSRDKLLSAEPLPDEVKDRSLELVHEAGVEVLMSHRVDKTEEFIDNGHKAYKVYFTNGHTLVADSVIVAISRSVPSTTFLPRDVLNEEGYVKIQPSLHFPSETPNSDDHLAIGDLVKWSGIKRCGGAMHMGYLAANNIHMRMKQAVSGTEPTYLELDEIPPMIGLAVGKKAVAYWPTNGVSSGEDVNKLFFGDDLGFDICWNHLRLGGYDVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUR5</accession>
    <name>A0AAE0MUR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cwf18 pre-mRNA splicing factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_106937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
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        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 560.94</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="230" mass="26050" checksum="C639FE926631BE16" modified="2024-05-29" version="1">MDHSDYLQNEGPRSFRRRFTDIKPPSALRIGPIKPLSLQPKRSTSYPLSNPSYNKPSQDSSSNDTIQPLNSPTTLLPPTSTTTTGTNSTTSDDPPNPNPSTNILTRADIIQHIQLKKFLEAFIRRRKNLKTELEDRLRLLKQEAKNNRRRRQNVFFYPSAASAAANNAANNGNNSNMNGNGMLDLQKEQRIDGLVEERIRLAHETYEQQLSLLVNEFVVVGLREEVLRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW76</accession>
    <name>A0AAE0MW76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_562587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685894.1">
        <property type="nucleotide sequence ID" value="XM_062830205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW76"/>
    <dbReference type="GeneID" id="87867359"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="914"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="914"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3354516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1047" mass="119527" checksum="1B9CDF59BE259CF4" modified="2024-05-29" version="1">MDANAIRSCIVATLDADADLRRRAELQLKQAEQQVGFTDVLLDLLQTEQDVNLKLSTVIYLKNRVNRAWQRSDDYPQEAVLDEDAKARFRDRLLPILASSETLVRHQLVPILQRILHFDFPERWPTFMDYTVQLLNTNNAPSVLAGLQCLLAICRSFRYKMSDTDNRAQFEKIVEVSFPRLLAVCDELVNQDSEEAGEMLHIALKAYKHTAWLELPACLREQSVNLGWCTIFLRTVSKPIPASAMQDDPLGRERHHWWKAKKWAYFNLNRLYIRYGNPHNIMEKGADGQLLQFAKNFIAQVAPEILKHYLTEIEKWVAKTVWLSRPCLSYTLVFLDECIRPKEMWTHLKPHLTNLVTHFIFPVLCLSEEDVENFEEEPEEYLHRKLNFFEEVSAPDVAAVNFLVSLTKARRKQTFEILKFVNEVVNQYEQAPEDQKNHLAKEGALRMIGTLAPVILGKKSPIADQVEYFLVRYVFPDFTNPQGFLRARACDTIEKFEQLDFKDQQNLLTVYRHILDCMADPKLPVRVTAALALQPMIRHEIIRTSMQQNIPTVMQQLLKLANEADIDALANVMEDFVEVFATELTPFAVALSEQLRDTYLRIVRELLENNERRDGAEDEFGDYLDDKSITALGVLQTIGTLILTLESTPEVLLHIESVLMPVIQITLENKLYDLYNEVFEIIDSCTFAAKQISPNMWQAFELIHTTFKSGAELYLEDMLPALDNFVQYGAPQLVQKPEYIQALFEMVQDMFNDTKVGGCDRICACKLSEAMMLSLRGHIDQCVQGFVGLAMNVLTSQDVKVKSYKIHLMEMVINAVYYNPLLTLQILESQGWTNKFFSLWFSSMDSFSRVHDKKLCIVAIVALISIPADQIPPTVAVGWPRLLQGITSLFGSLPTALKNREEALKDDYHLDGASYDENEEWDDDENNWDAGEEGEEEDLGDVKGESEAYLEFLNEEAQKFSGTDLEYSDDELGEDGVLLESPLDKLDPYSIFKTSLLKLQAEQPQYYAGLVQHLSMEEQSVISAVLQQADTQEAAAQQAAAAANGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWI2</accession>
    <name>A0AAE0MWI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_145601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685445.1">
        <property type="nucleotide sequence ID" value="XM_062820997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWI2"/>
    <dbReference type="GeneID" id="87858151"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3352150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="573" mass="61626" checksum="07B6F346709957A8" modified="2024-05-29" version="1">MGTQDPISSVQPDLEQSSHTGGNGNDGNDELDESRLAQFGYKQELNRDWGLAHNFGVSFSIISVVTGLTTLFSYGLSTGGPAVMSISWIVVSFFTLLVAIAMAEIVSAIPTSGGPYFWSAMLAPPRWSPFLSWLTGWFNLLGQVAVTTGITFGLAGLVSTAITVKSPDYEPTAAKTIGIYAALLVSHGVLNTFGVKALRILNNVSIVLHSAGITALCIAVLAKAPKLQSAKFVFGKYHDGTAAEEGVEGWGQRASPGYVVLCGALLSQYTLTGFDASAHLSEETKNASWSAPIGVVSSVGFSSLFGFFVLLSFLFSIQDFERVLDSRYGQPVLQIFVDVLSEDGALVLFSLIMVCVWHCGLFSMTSNSRMMFSFARDRGIPSFFHQVDARFKSPIRAVWLAATLSFILALPSLGSEVAFGAATSIATIGLYLSYGLPILIGLFWHKNFTAIKGPFNLGALSRPIAGAACLWICFITVVFCLPTANPVTSQTLNYTVVAVGIIAVGSIGLWVVWARRWFTGPAAEAAEAMRLGVDITEPGALERKEKEALEEARMEGERERREREEKQAPADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWQ1</accession>
    <name>A0AAE0MWQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_555050</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687048.1">
        <property type="nucleotide sequence ID" value="XM_062830010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWQ1"/>
    <dbReference type="GeneID" id="87867164"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="73"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="315"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3355670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="410" mass="47313" checksum="535A47AE1A5653B0" modified="2024-05-29" version="1">MPANSVAALPYNMKMKEENTKRKATEEPTSPSSAKRIKHSDSTEETEDTKKPKIPAIPFPEKAAVIEERNGEIEFRVVNNDGERESLIILTGLKCIFQKQLPKMPKDYIARLVYDRTHLSIAIVKKPLEVVGGITYRPFKGRQFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDVMHFLTYADNYAIGYFKKQGFTKEITLDKSVWMGYIKDYEGGTIMQCSMLPRVRYLEMGRMLLKQKECVQAKIRAYSKSHIVHQPPKQWKNGVTPIDPLSVEAIRASGWSPDMDELARQPRHGPNYNQLLHLLNDLQNHASSWPFLVPVNKDEVHDYYDVIKEPMDLSTMEDKLEKDQYNTPEDFIKDAKLIFDNCRKYNNENTPYAKCANKVEKYMWQQIKAIPEWSHLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWS6</accession>
    <name>A0AAE0MWS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CwfJ C-terminus 1-domain-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_9717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685745.1">
        <property type="nucleotide sequence ID" value="XM_062831626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWS6"/>
    <dbReference type="GeneID" id="87868780"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="324"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="514"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="574" mass="63761" checksum="E98C147CDF726B40" modified="2024-05-29" version="1">MAAKMSVRSQLHFNNITHTDQISFVFGSINGQLQSAFSKLSTLHAKNVFSFAIVTGNLFDESQDDEQLTALLAGEIQIPCPTYFTVGTVPLPAQVIERIEKDEEIAPNLHYLGKRSVTKTSEGVRIVTLGGLLDPAVVVGQSKEQHLPFHTEGDIKSLRGANNADILLTTVWPADVWKNSAKAREQNLPTDAIPSSQAIADLCAHLKPRYHFTMSPDNFAFEREPFFPSEPRGEEDKDKGLDVTRFISLAPWANTAKAKSMYAFTLNREAVLSPPVGSTLTPFYKPAAAAQKRTADEAGFSRFANGNHEKRRKHQRRERSPPPGPERCFFCLSNPNLPTHMICSIGEEAYLATAKGPLPSAETFKAQGLDFPGHLIITPTPHIPSLNVAALAESGEDVKKTFKEMTRFRESLQGMVSKQSKGKLGAVTWEINRARNIHVHWQFMPVPAEMVRKGLVEAGFQVLAKDTNIGKFVSREFETADEVPGDYLRVWIWAEEEGDAEKGGAEGGQVISKTLLLQIDENVRFDLQFPRKVMAKLLGEEDRVVWQDVGQSVEDESQDVAAFRAAFKEWDFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWS7</accession>
    <name>A0AAE0MWS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_545002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687138.1">
        <property type="nucleotide sequence ID" value="XM_062829340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWS7"/>
    <dbReference type="GeneID" id="87866494"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="66" mass="7287" checksum="0F6CE473E1DFB695" modified="2024-05-29" version="1">MCDFFKNYYIYASCTDPGLHFYKIELDGSPQGACPRAPHERFIVKGDKCGATNKQGRETGNLVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWZ2</accession>
    <name>A0AAE0MWZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_16056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685895.1">
        <property type="nucleotide sequence ID" value="XM_062821228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWZ2"/>
    <dbReference type="GeneID" id="87858382"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001000">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="353"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3354517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="717" mass="78771" checksum="5CA27D680BA8B134" modified="2024-05-29" version="1">MAASVLAAAATQTSLEDHPHTSHSEPNLPGPEPSPHQYPTDLSSAIPEEGDETESDATNEPVTPVSGRQSQDFHESLVAPDAHPSDDDDVTYGSIVAPGKPRDSFSAASAVSSKSTLNLNAHYTPAPRARKNSIAESTATTTTGRRSNTFKRAMSGIFRRTASTLERSVPGLMDHHGDSAVLDPHPHDMTQPRDIPGRRFSLARSSNTTTRSNTPPSPGSPLEMSIMSKEQASSPTVPGPDAFFDKKKRATTGLGLRSRAINFITNNASHDETKHLRRPLRRRASSFDTSKREKSAKSSAAHPQVEMSRAPWEIPAPTGTGLKARRLSLSLPDDFTVDVVDLLSEFEYHNKLLRRHATIGKGGSAKVTLVSRKGQPDEIYAVKQFRAKSSSETTEEYRKKILSEYTVSKSLHHPNIVETIRLCTHHGLYSHVMEYCSEGDLFSLVQKKYLMSEDREKDRLCLFKQLVQAVNYLHSNGIAHRDIKLENILITSDSKLKLADFGVSEVFSGRHPGEREAGGQCGQGMVEVRRCAGGYLGSLPYVPPEILEKATDYDPRAVDVWGVAVCMLAMTFGGSIWNQATLTPPDGSKPDVCYVQLAEGWRKWNAKHAGQTDPVPADTDMPRAKFMDFAVTHNGLRRLLLQMLNPNPDKRISITDVFNSRLVKNIECCQLESYEDPSKTIDASKKGAFGKGAPQKIFCHNHLPPKPHHVAAVIGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX17</accession>
    <name>A0AAE0MX17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_66328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687422.1">
        <property type="nucleotide sequence ID" value="XM_062831242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX17"/>
    <dbReference type="GeneID" id="87868396"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3356045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="990" mass="110860" checksum="D6A17AC0941B16FB" modified="2024-05-29" version="1">MPIDDNQSAISVASEGSPCVDHPSIGPSHDSFDIHQHHLVAHHPPPGASVYPPSAPFSGALNPRSCVTCRRRKVRCDKHMPCSNCRRAQIPCIFPAPGRAPRRPRPKDPNAPSKQPSSERELELMKRLRKLEGIVEELSGQIELEAVRHPLSSSNSPEGTGVHDADGHTPGATRAADKAGTPNGSNFGKNSPSTGTGMGTDRSGAHGLQTQLNRPPFGPLRRISSDIHKQFGRLVLNEKGVTRYVSSGFWSAINDELDEIRRETINCGHHDSDDSDDEGSPESVDQPVSHSDHQSFIFGYRSADVDLRPLHPLPSQIPFMWQVFQENVDPILKVLHVPSMTKTIRHARNNMDSLTPSTEALMFAIYYSAVASMDKDEAKMNFGAEKDYLVQQYRFGCEQALARANFTTTPDITLAQAFLLFLILVRRQDDTRFAWTLTGLLIRISQALGLHRDGTNFPNISPFEVEMRRRIFWAVCVLDLRSAEDQGTDLTLVDRTFDTQLPLNVNDSDISPDMKDFPESRDGPTDMTFSLIRYEICTVARRLHTASSAMAPVCPVDAESSLEEREEMLAELHRRVEEKYLRDRSCLDNPMYWVAANIARVMVAKMTLVIYQPVLFPGPDSEELSDELRERLFNSAIEVFETNHILNTNPKSKPWRWLFLTYTQWQAVAYLLIEVSHKAWGPASERAWGALNSVYTAPKEYELEKLASHTAVWLPIKKMYFKAKRHREAETARLRANPQAAMQLELEDQSRPAPTTFGALSVTEEISITVARERWRKLVNAPPLPVEPVPPPRQPTPEIPQTVQQQTNEVRTDDNSHPTENMGVPKPEMMDFLDPTMADQAFNPQEFIPLWRGPSFDPSRPPVYGFPNGDIPRIDSAANFNPATIPDFNRSTTPAPAGGNQLHHTPGPGPNMNTARGMQVQSPVKDENAPWLWPGAGLPEMLRVPNFQVEDMDVNMDESFDWQNWQESLGRFEMETNGGSAATSTWGPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX95</accession>
    <name>A0AAE0MX95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_54948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687049.1">
        <property type="nucleotide sequence ID" value="XM_062829660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX95"/>
    <dbReference type="GeneID" id="87866814"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="464" mass="52218" checksum="03F04BBD888FE96D" modified="2024-05-29" version="1">MEEQDVAQHDNDNSVTHGIYENVVAHVDNDNVDADPDWSENRPATSANRVGRPPKRGRGRPRIHQRGRNTNRGRSTWTQPQAQKEPKAHDQPSGEKKTVTPFFEPRKTRATAKKEDLVLQEAIRTSTEPDSRHGSRALSAGADKETVIMNTGFDARASKAGPEKSRPDYAVQPLQNLETTKKLPDQELDGGKKTGGNGTESNVSNVSQGHTQGFIQAPEPLIYPDGFGKWEQQAALDRYGEDVLSEFRGIWREILKSIDTDAPNRRSAVDVWKSLLDPDLATRFRASLSARYREYTNRCKQKMEQGTPKRNSSGQPGKRQHEEAESPEQDDSPVPPHPKRRKRAASPPSDRSMQQQEQQQNQPGKRQHEEVESQEQEDSPVPHPKRRKLATSSQSDSTFSDSSGPRQGSAWRMIRDPYGESVTDLPRKHDIEAESPSKKVSFRIRKEGISKTQTQRKNNPIGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXI6</accession>
    <name>A0AAE0MXI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_453773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687380.1">
        <property type="nucleotide sequence ID" value="XM_062826167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXI6"/>
    <dbReference type="GeneID" id="87863321"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="72184" checksum="453C1D55E559C1BF" modified="2024-05-29" version="1">MGKGFQFIDSTKTDRVTRRLVRSHAMKGKNVGKVLHRRSRLELDLHTPRPSKKACTSSTARNLLPQQGQQPTSVSTSTSRPSSTKSRSKSPEETPSPSDGSSSTRSSSYITTPASSVTDLTSNDFLFLDDLDNLDWLADVENHEIDGYIVDTLSSPPVDTSFQGQQVQQSLILEAHTQKALNTTLGARDSLFALAFPVQATPQSQYVISQFFGIVIDALYPPQLVRGAAKAYDYWMSNLFQDRTSFHCAIALMAALSDFFFGDQALTPDAIYHLSQAIHMVNRTLETNGALSDSNLAVVNFLVIQELLRDSMKSKAEVHLKGLQRMLELRGGLNSLGEENPLGIKISKTAVDYALHRGTPIPAPFYRDRMSSIRARLLSEGFILSSPPSPFFSLSPISPSSSLSSPGGLGSVQQQIQIHPFLSQILSDVLSITHLLNSPFLNFRFDPHTLQEFLVSVGCRLIRFRPLSYYNQTPQRGKRQPPPPPPTKQQSRIESAIHLGLIALTTTLFLQFGRRRFLRYELVKDCITSLINDWDFHSSLATTGSTQGSESSDDIENQTLLWLLHIGGISVLAGPEEQKWLAPKLQELAWGVMGILEWEGSGTPPQGTAEGGSSGIGTTRGIRECLLRFPWVDSLHSEPGRAMWDSLGVMGMGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J708</accession>
    <name>A0AAE0J708_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_312489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677549.1">
        <property type="nucleotide sequence ID" value="XM_062823323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J708"/>
    <dbReference type="GeneID" id="87860477"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13131" checksum="167F1105C81CE7CF" modified="2024-05-29" version="1">MDGYGTNVNEPAADALLTHAKIYALAEKYLISGLKAVALRQFKAAATVSLDIDDFLGAALVVYESTIEDDRGLRDVVVETLCKHSEWLDEEKVRDVVKELGALTYDMVIYMRQKRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7Y8</accession>
    <name>A0AAE0J7Y8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3' exoribonuclease family, domain 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_552683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677656.1">
        <property type="nucleotide sequence ID" value="XM_062829904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7Y8"/>
    <dbReference type="GeneID" id="87867058"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000019">
        <property type="entry name" value="3 exoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="41"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="286" mass="30396" checksum="36D7DBDE985DA38B" modified="2024-05-29" version="1">MADRRRINGPVGTTIPPIYDDASEKKSEVARATRSRPANVIRKMYLKTGVTPSASGSAYLEIESSGNGGSGLKLSCSVHGPRALPRSTPFSPHIILSTHVKFAPFATKQRRGYIRDPIERDLGTHLEAALRGSIIADRWPKSGVDIIISIVEGEQDRETSKAQGIEAWDTMNALSGCITVASAALADAGIDCVDTVAGGVAALVQDAGDDAAPSIVVDPIPSEHDKVLAACCIAYLPTRQEVTNLWFKGDLPASDMDVYTQLVEKGIQASKSANRVLVDCLNETVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J812</accession>
    <name>A0AAE0J812_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_502782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678039.1">
        <property type="nucleotide sequence ID" value="XM_062827862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J812"/>
    <dbReference type="GeneID" id="87865016"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="314"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3338588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56246" checksum="1A146E5E06982908" modified="2024-05-29" version="1">MLFSTPNSRSRRQWLVSLAAIATSLVTNILAAEIAPHELPSYHYGAPIRVECMNRSSETGEHIETPAHEIQWIPFPMCEETKAPLEFNYGIETEQNCTIPMIDDPFFHLLEFYIHSDAPLACRLPAHPPPQVEIVGEKPHVTEYIPLVFALAGTLQLSHMHISTHMNVLLHSTPKHHLHKKDSGVLDSATAYSTSPLTHMEGSSTRRLVIGDPLPLQFSVRWFPTPELPRVEGKVEWQGMGGHIYASTVFYALVSFGAGVCVSSVWFFGSVLPQRLKGRSLGGATPLGYGMGVDLTTFGYRSTNNMAVYNESRLNYVWLAWFALSIPIILFIDALHFYPSSWYSSPSAPLHIFHLVRQDYIAQYNDPIVQWSPATSVPGSHDSWIGLFLYLEFGFTLPVGLYGFFKLAVKRKGTTGRDELLFLVYALETALTTLVCIYDVGYWDPAVYSEEVRRTMILQFFGPWFLVPSIMAVDMARRILGRIKVADEAMEETERRKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8Q9</accession>
    <name>A0AAE0J8Q9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dihydroorotate dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_511346</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678443.1">
        <property type="nucleotide sequence ID" value="XM_062828477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8Q9"/>
    <dbReference type="GeneID" id="87865631"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009220">
        <property type="term" value="P:pyrimidine ribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="397"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3339083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="749" mass="81563" checksum="0750D848C5E5C328" modified="2024-05-29" version="1">MAAESLLRAVLRRKVEFLRHVRQRRAHHSHKPPTAGEQIPTPGNVPTLPFWQRLGPLTRAAMAYARAQRKRPYTTQVATSLVICFTADLSAQRMGGRDYDPKRTVRSLIVGSISSIPSYKWMLWLSNKFNYSSHILSLGTKVVVNQICFTPIFNTYFFGMHAFLAGESWNNIVERIRVTVPVSFVNSWKLWPAVTAISFTFIPMEYRSLFAGVVAVGWQTYLSFLNRKAEDGKTIEPAPALAVKAVEAPVVAGSTQAAAAATRPALSAALRPLAPKPRLQSFPRRPNSTTTTTTTTTTATPTPTEPTKAAVADPSILPRRLKLSAYAAALAAVLGVGYYYATDTRASVHQYLVPRLLRTIYPDAEEAHHVGTAALKGLYEVGLHIRERVPEYPNGPLSVNVFGKQLLNPIGISAGLDKDAEIPDPLFALGAGVVEVGGCTPFPQEGNPKPRVFRIPSVDGLINRYGLNSRGADAMATRLRERLRKFARSVGLTENQVLNEEGTDDIPPGSLHPGRLLCVQIAKNKKTDEKDVNAVIRDYVYCVDKLAPYADVLVVNVSSPNTPGLRDLQATEPLTKLLSAVVDAAQQTKRKIKPRVMVKVSPDEDDDTQMEGVVEAVWNSGVDGVIVGNTTKRRTGIVPKGVKLIDDEPNILHEEGGFSGPALFKNTLSLVGRYRKMLDGYALKSESDKSAAQKVLFASGGITNGEQALKVLNAGASVAMVYTGMVYTGSGTITRIKTEMKEKLAVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8R3</accession>
    <name>A0AAE0J8R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_291212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678507.1">
        <property type="nucleotide sequence ID" value="XM_062823015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8R3"/>
    <dbReference type="GeneID" id="87860169"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="90"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="517" mass="59335" checksum="875F24384AE359B6" modified="2024-05-29" version="1">MLIPYYLSAGPQAFEAKQESKRVKIGFPNLTVSSSQHMGLMRQWLEYCDSRHQCKPQANSSVPTRVIDLGTGKEHTVRLCETKPGDSFRYIALSHCWGTEQHFLTTATNIEEHKRSIPIQTLPRTFQHAIQTTRQLGIRYLWIDSICIIQGDHGDFDKEAEKMESVFSSAYCVLAASSARSQQDGFLNPRKARKVINMVKEGHTRGGVYVSLFSDDFKVHVVNSPLSERGWVLQERALARRTIYFTEWQTYWECGDGIRCETLTLMDNKLISFLGDPNFPSKLSDGTSDRGEKIRFYEGLYKQYSRLTLSRDSDRPIAIAGLEKRLIHDLKSSGGFGVFDDERSLLPRSLLWQRGREFRTLEKIGSQVLPRVPTWSWMAYKGGIDYLDPPFGEVDWNISEIRGNWFGKGNRAELSAITREFRMATTGTTDFDITWDIPKEINSDQARLKCVVVGVLRRRGVSAERKTHYVLIVRLREHDAELPTDETEVYERVGVGKMLGQYIDLNNSQPREWVKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8S3</accession>
    <name>A0AAE0J8S3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_432918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678509.1">
        <property type="nucleotide sequence ID" value="XM_062825031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8S3"/>
    <dbReference type="GeneID" id="87862185"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="279"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3339149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="822" mass="92259" checksum="228699A777F1CA3B" modified="2024-05-29" version="1">MLTHLNQGESFKGKADGTGCRQPFAYHHPETWSRCEAYRDTNILGRVFVDDGWPPPDVPPVPEEGPQRDPDTFLATVIGLLPEICPEYARKHGHEYGWNPEPFLNRVLEEEGNGTKYPRRAKKRKRGDEDVGDNAKESKLQKLHKKYEGRVSQHNRDHNYTRVCRVLLKEAFPKAYVGDIEDAMSKHNFSVYQTYSALHEDFSKPHGVTFRRKTFPRHKNNIEEVAIDNEDDTPPGREAQQEFLAAQEVCSARLAKDAAEEARQREERENLENAKAEGAIIECGCCFDELPYNRMAHCDGDTPHWFCYDCARRQAENQIGQQRYHLGCMSMDGCEATFSRDQKDLFLDDRLKRTLEEIEQNDSIRRAGIEGLETCPFCNYAAEYPPVEVNWEFECQQPECGVKSCRRCRQETHIGKSCEEAMAEAARNKGEDAKRKLEEARSLAMIRECYKCNNRFIKESGCNKMTCPRCRAMQCYVCRQPCDYSHFDDVHRGGKKGNCPLFEQQSLDEIHDKEAREAEERERKKLLEADPSIDAQELEIKFDEKLFPKRQQHVHANGVRAPGAYPGRIPAPIRHALAGAIARPRVRGPNQAQPGMPGAAHVQPVGQEADLLQQYVRLGLPPGPIRDRFMERWGRRYAQLAAQRNRGPVQPHQGQVVNGGHPNQGMNQGLAGYAAPGVHPNPYPNPLPNYNANPAPNPAPNPAPNPVQAPQAFPGFGNQVLHHNHNHNHYMLNAHFPANVPDWNPGGPGLLGLGLGPLPPNDGFGLPQMAQPAAPRMAALPPPVAVNNVPNPSVNVRSFGRAPVVAVPPGQQVPVVDLTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8U6</accession>
    <name>A0AAE0J8U6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_511302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678390.1">
        <property type="nucleotide sequence ID" value="XM_062828473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8U6"/>
    <dbReference type="GeneID" id="87865627"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="211"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3339030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="557" mass="62594" checksum="735BD3DFAF02F7B8" modified="2024-05-29" version="1">MNSRFESVSPYTEQQHLLDLTTLDIENQILALALTQLTCLREDYATAPYRDTFNWDQIIEHVRALAQKRNHTWKETSFFVVAFRSQVLESTVENYADLGELDKAAHAEATASGGFLKYWFGTPNEERRNLATCIWRSPEDAKKGGTGPAHRKAAGATRSLSSPPRLTNSPSSSLTTATAYPTTPSRLHVRIESRQSAIMAEVQKDAPIKSVQVEALVVMKIVKHCSTSFPTVATGSVVGMDNNGVIEVTNTFQFPTVDTSSSDSHSDASSLAAAAPRAKANIVYQNEMIRHLKEVNVDANNVGWYTSATMGNFINMSFIENQYHYQKENEKTVALVHDVSRSSQGALSLRAFKLSPEFMTAYKEAKFTTESLRNSKLTYKDIFVELPVNVHNSHLLTSFLHQIPAPPKSAEIPMPASLDDIRRDPVQIPAHPGFESLDLSIDPFLEKTCDLLLDSIESHYTDLNNHQYYQRQLTREQFKITQWQAKRKAENAARLAAKQQPLPEDEWQRLFKLPQEPSRLEGMLNARQVDQYARQVDAFTANITAKMFAVRGNLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J910</accession>
    <name>A0AAE0J910_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_323540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677902.1">
        <property type="nucleotide sequence ID" value="XM_062823442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J910"/>
    <dbReference type="GeneID" id="87860596"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3338451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="244" mass="27089" checksum="50530BC997CBF0EC" modified="2024-05-29" version="1">MMKMLTTSAGVRLLSPAAVRQATITASRAPTTASAILVSSRRQYATTQETSKRRSVTPFNDNGHVPWTRLSAGEKAGRAVQQTFNFGLVILGVVLTGGIAYLLFTDVISPESKTAYFNRAVDRIRADPRCVALLSPGNPKAIAAHGEETYNKWRRARPIAATVEKDSRGVEHLKMHFNVEGPRGSGVVRLHLTKQPGHWEHEYQTFYVDVRGHQRIYLENKEAEMAAAKKGGNKEFKFLGVKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9J2</accession>
    <name>A0AAE0J9J2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spo7-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_301748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678835.1">
        <property type="nucleotide sequence ID" value="XM_062823146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9J2"/>
    <dbReference type="GeneID" id="87860300"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="448" mass="49923" checksum="8C13D45127BC0510" modified="2024-05-29" version="1">MADALDSIVKGAPMPQDLPHLNNLNRAISGTTPIASSSNAPSTPTKGSHNGGAGASSDPLSHTPSSPSMIYLNLLILEASLRAQYLELRARRRHHTFFLVLLGLWTAGFGYALFLAPREDGSGVGGSVYWVVETGEKVCFLGGIMTGVLVWATGIWERGVRWPRRWLTVSNRGLRGFNCKVVLMKRPWWKEALGTIGWFLTYGLFSNATSSYHYVEPAILKEVDRELGLSGHGHPTLPVVNVGHDMEKGGHEEDLSPGDDYVKLLLLAKPFSPTFRENWELYRSEYWEKENERRALLRAKLKERDRKLRKQTGGWFWWLPWRRTAKTQHHHHHHGSSVSEKALHPRAAAVSSELRRTRSTSTRRGSMNGSALRSTTPTPSSRGEHDEPGLTRKGTFSLTPEKVRRKKTLAPPGSATKTRPRVESRSVTPENPSPLAKESSLEPEGTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA16</accession>
    <name>A0AAE0JA16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_408145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678806.1">
        <property type="nucleotide sequence ID" value="XM_062823820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA16"/>
    <dbReference type="GeneID" id="87860974"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="117"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="497" mass="55006" checksum="807D11B784ABCB76" modified="2024-05-29" version="1" fragment="single">MSQRLHNTEGWEDDKGQEQSRPAPLQQISAATAMSATRMPAPGLPAAPATGSADTETSADTETSAGVQSPKQNLYYKVPMSRGHIRLLQLLPSENEDAAIHCRLFCTRLDSKGTRPYEALSYVWGSEAKPCSISINGCDLPVGENLHAALLHLRDHSIERTIWIDAICINQDDEEEKGHQVQSMAKIYAKASRVIVWLGEEAAGSDQALEEIRIAAKRDQAPEEIRIAAELSTRRLDNKAGILTLLQRPWFQRIWVLQEVAAARHILIKCGSAEVDGFAFCSGLKALNLSNELPADLRAQILSVTYLIRGAIFRPKYATSQSDNFSLNIRPLSELIEMYHTRKATKRLDKVYALLGMSSDNPTAAGLFADYKISWKQLFKKLIHVVLSELVSVNGLSDDKEIAVIEGKGCILGEVSSVKRNAIWEDRQDMAITWRNAPSYICVKEAWGFCWTLPTTVKSVQKGDVVCLLQGASRPTILRPYNDHWAVIMIAVSPAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA28</accession>
    <name>A0AAE0JA28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_250251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679065.1">
        <property type="nucleotide sequence ID" value="XM_062822447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA28"/>
    <dbReference type="GeneID" id="87859601"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="60"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="269" mass="31345" checksum="655FB512FBDFC7FF" modified="2024-05-29" version="1">MGLAATADAPKDTTPETNQFVNWVSDFLPDDLPPTIRREVRIFYYNYDSYWQRDALHTRLELLGKRLLEHIRGIRITEAERSRDLIFVGYSYGGLVVKQTLVQAQRNRDHNHVNRDLNQIAEYTKAILFLGTPHHGSSLSRLGWWVAQALRLRGSNPSILANLDCDSVPLFDLHSDFTEITRDDWYIFNFFEQRRIEIFRFGLIRWELFGVPEQSSTYHGSKVRNIGLPVDHYGLNKFGTRSESYQIILSILKEVTVSRSRSKKRHYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA39</accession>
    <name>A0AAE0JA39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_471873</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679229.1">
        <property type="nucleotide sequence ID" value="XM_062827121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA39"/>
    <dbReference type="GeneID" id="87864275"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
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            <end position="146"/>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="34"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <ligand>
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            <position position="95"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
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                <person name="Ament-Velasquez S.L."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 560.94</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
    <sequence length="95" mass="10584" checksum="337A02443504BE12" modified="2024-05-29" version="1">MQHRVTCMVGAVLSLLGVAAIWLQRGCQTLFLKGPAESVQSFRQIPSCPGPAQRPCRTSYPVPIYCLMLRLINEVEASNGTLFMVYFLECIILHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAX3</accession>
    <name>A0AAE0JAX3_9PEZI</name>
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            <fullName evidence="12">PQ loop repeat-domain-containing protein</fullName>
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    <gene>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679632.1">
        <property type="nucleotide sequence ID" value="XM_062827816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAX3"/>
    <dbReference type="GeneID" id="87864970"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3340690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="481" mass="52461" checksum="67309C735A1971E7" modified="2024-05-29" version="1">MPLAPPTELLHLDVEAISGILGSVSIACWVVVFSPQIIENFRRSSADGLSIQFIIIWLTGDVFNILGAVLQGVLPTMLILAIYYTIADVVLLGQCFYYRGFTWRDEVAIVDEVVESDGDSRKNKRKGRGDGSRREGENLGSGSGPDERTALLGGAGGERGNAGVASSAASATTNTTLTPHHGHHLGPYDGTRERRGSWSHLSPAVPLVDPAELEADILHRRRGRNGNRSRTSASSGGPTKLQSFLFNMLAILMVCAAGVMGWFLSREYYPQQQPSTELPSSDPKDGDLPKTGVEFSFWGQIYGYLSAILYLGSRLPQLLLNFRRKSTEGVSMLFFLFACLGNLTYVLSILAYDGSSECAAGPGDCEAGEEGKIYWRYVLVNGSWLAGSAGTLLLDGAIFMQFFLYNKEEVWGDEDDESEWDSESGSGSGSSVISERSGRVSEDGEEGGEQGQESDGRGWDSDDERSKLDEDEMRDRRRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBU9</accession>
    <name>A0AAE0JBU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_258891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679372.1">
        <property type="nucleotide sequence ID" value="XM_062822590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBU9"/>
    <dbReference type="GeneID" id="87859744"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1020" mass="110303" checksum="0E6D705E6D33A8ED" modified="2024-05-29" version="1">MPIAPSPRDRITSPYLDAVSTASFATSPSPNAREWIKNLPAMAGSPGNILSLAGESPPTAPSSYTPSSFEDTRGMSSGWSSPRPPSNLYAASVSPPTAGRRPMSFHMAKSPAELHGHLGEPASRRSSMHSHFARAGNPPLPHQPQPHFYSAPGFNLDTHRHDGIKAGDRGYYFGYDTIASPSLDHVMRNDKVVLAGYEGGLEVHKLTKGGHLEAFASLKGLRGGVYHAKVLPWTAAQADVFPLIAVVVHGPDLPPIQSSPNSAPKTEGDYDAVSEDRSEAMANVPLDAPKDTPGDRAVPGFIECYQTTVEIYSLKTNKLVDILLEAPKIPLKTSVLSPIFQAPLPSGAFHIHADGGSVVISSGITGECWVYQQVVTDESAPRFVCHGKLWTTLQQTPRGSDGSQDMDRNYTPVPPRPRPQTAILSVRGKWIAYCPATPSSQITLRATVPVPIYGRAPNLSSLTPGQLPPASSEIDLPLGDSVVNKIVRDATQELIQGAKWVGKQGWQAWNSYWNPQTNPTSRSPVLAPQSWGGSAQPDPSQFPPTHGTITPPVAKDPNMISIVDLEILSSSATIHPVTSFHIPQGCSFLSFSPSGLSLFTASCKGDVQTVWDLMRLQYTKSSPLQGTGLSTTGGPRVRQVAQFSRMTVTRIVDVAWTQPNGERIAMVTERGTVHILDLPVSAFSWPPPRRRIRPSEATNSVSEGTSAIAIASNALSSVREVARPLISRPRRTSSNGQLVGSGIGDYATHGGKVIAASISHSLGKTGHAISQLRHTGENRVSLPTSNSAPGMSCVTWVTGKRGHLLYVLGNGLVRSFAVMNRRTSGGERRAPRLSRHKDVKVPLMPDLSLAARAKAFVDQEEYYEFTERDLDTGNETMVLDRHRARAKITNLAIRSSIPQAEIESSAPYQPFHTDRRVALYEVEDGSGASQAWAFGGRIQGRKLDLGLHQLGDDDFMFNDDLRALPPSAMERVLERNGDTDQVVVTTRRKRGASRLTAAALDYDGFFEDDCEVLDFADQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBW5</accession>
    <name>A0AAE0JBW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_431692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679756.1">
        <property type="nucleotide sequence ID" value="XM_062824962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBW5"/>
    <dbReference type="GeneID" id="87862116"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF79">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="46"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="732" mass="83384" checksum="E30B26BD4D411544" modified="2024-05-29" version="1">MFTYSPLSREKRETRVFRYSPACQSTPDSISLELRHASLDDDALQYRALSYVWGDTKDKDDIEVNGEQFSVGENLHALLQMLQHHGVESWLWADAICIQQSDDDEKSWHVQSMCDIFKNAELVYSWLGPGSEATDVAMEFFADWGPRALEVGVMEKLWPTDIPMDGSFSSRLTASLNLHKLERYFLPEPYWHRIWIFQEVALAREVLLICGGKLTPISYFEAVLEALWKFRGGLLTPFWDKCPLRRGFCERFPSHLYPNKAMLIRQLLCRGTKLSLGNILVAFSNQTERPWYQATDPRDIVYGILGLLSNDDRRPFGHVDYKNMTWVDLFTQATRSLIKASLTSSLFADDVLYNIGHCLPRPRDQPSELPSWVPDWRDVGVNGLPQSLVAMRLAYLDASDSRMESSYHIFWGHGNSSAIQLPGYRVDFVTDVMAYDYQAENALEKDRPSDWLAHIREFTGLPVSSDTWNLEGEDYVWRLVMDSRNANFLGLWLKEPKYKTEAACFIRRLMRQDYPDPESLPDFLVEYIQRSGELKALSKIRSSKRTLKRKLSNPDDDTCRGATTITDGKAQTKSESVDPECVTDSISESDLRSFMDAKIRALFRRSRSKNSTLFKTTKGMLGNGIGDVRPGDIVVILQNAHTPFILRPRPQDGDEIATDRGGSGSTFTFGGEAWFFTTKISGASFMLVLYAFNATNNRIVSNGTTRTENVRLKEGFSKDQTSSSKSMRQPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC58</accession>
    <name>A0AAE0JC58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_575445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680139.1">
        <property type="nucleotide sequence ID" value="XM_062830619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC58"/>
    <dbReference type="GeneID" id="87867773"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042268817" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="238"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="290"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3342346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="390" mass="42420" checksum="E58A9A34E49F06B4" modified="2024-05-29" version="1">MMPPYVLRPLLLLSLGLIVHTTSAAVQLLNFTATDLPGLTSTCRSVINQAINCDPVFQDAARIGLDVIKFWNDDTLSKFCTSTCDAALSTWMRRVQGACASQYFAVGEGFGQSPAAYVEQYYEIYRATCVKDPSGKLCNAIFRDAANIDPLNQVVTATPKTSFECNSCYLTMLATRLQMPLASNPIWESAFTYLTSSCGISTMTLTPPVPSTWIVPITTTGTATSTASAEPTETCSGTKYTLKAGDTCLSVSTSHGMSTINLAVANHLSAFCYDFPTEGTLCIPTDRQCTPYIVKEDDTCVSIADSIDTTWNRLVSWNPELGINCNNLQDYVGHVICTSNPGGGWVDLNPEPTESPSATIHQKLDPVRHRGFTCRDRHSHHDQQLHHGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCE2</accession>
    <name>A0AAE0JCE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_575250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680068.1">
        <property type="nucleotide sequence ID" value="XM_062830613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCE2"/>
    <dbReference type="GeneID" id="87867767"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042223776" description="Cerato-platanin" evidence="4">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3342275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23038" checksum="9A204D5B309B6B8D" modified="2024-05-29" version="1">MLANALAVFGLMATTLTSAAVIPPVRRGEAIGITPHDKYSSSVGVLGCKIDINRVAYWPSSVSCNDICVRVTANGRSVTLLKIDSSTGAHDISYDAYAYLQNGVGAAGGAALGGAVDATYEYVSPEECRPLIKTPDGKLPFSAANSMSFVNSCQGGSWVGNNFQLYNIADARCQWGEDVPCSFPDLAVTNQPDCGAGHILGIQTVLPEEYPVVDIPYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JD27_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_467747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062826920.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87864074"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="337" mass="38521" checksum="C7D60177399AC9D7" modified="2024-05-29" version="1">MIQSLEVFIDTQFTPKAKSSAQLPISRRGVNMAHLQPEPTSPYNFGLRSDFEIALIQPFLYFFSGVFLDIYFPSHVAPKPTSPTELAFPNTCTPDEHLTSPDQRRNTIGEQALISLMFILVIMRASPYLDFKGPDPWAFDLPLAWPSFLKNKLLASEHVLPPDDYRVTQRREAMRLLFLVVISGLLCPIADYYCGRGEGAFVFWFDAVELPLSYVGSVPLTIAVILVFYRYGVSWGVQVMMMLSRITLPCVATAAASEALAYATFGRRYGVVDIWDRRIEKWVEAWKKEKSKADREVRDEVEMSERNKELLVWRRGMKEGNGYGPDYWLPREKGPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD61</accession>
    <name>A0AAE0JD61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_429116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680411.1">
        <property type="nucleotide sequence ID" value="XM_062824801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD61"/>
    <dbReference type="GeneID" id="87861955"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="926"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1088" mass="117064" checksum="C952D774E21CDC30" modified="2024-05-29" version="1">MEAAHSISARSMPSMSTQQHDTDSFPRPSSASLARKTSIRAVPYDPTDTRLPLAPSLSGASTGSYSPSSWPFPKGHQRQNSKSKLPLSMRSVPVDSGSPTKMAPRETSPTRKFAQRSVMRAAASAPSRQGSFHESSLRNETFSNGRESSTPDEERDSDEIDNGTIRASQTNGARMSESEERPKSRHGRPGSLTRASSSSLASRPKTPFPFSVPDDMPLERPTNPTPHAGLAKQSEALQDPRFTAEYFETISIHDHAPSPEPLTPPRRLSVAQSDSTDAMYGGSRQVSTFSTVHEVDEEDGDHDADTRDTRDTFDLERTMTFVHDSSEDQTFADKNITLGSSTQQDESIISARRTSSNPFGFHQNVDIGDGTPDRGIMLIDPNLTADLTNHNISRVTSGSRMWTPLPNIDSIRRGPKIRHHRVIPEPGSGGGGGPGGIAPARSGIIPPVNTLADLAILGGNGSGNKLNDLEEQDPDQQEIARRVLRLQKWLVPVSFGVLQVSIISFVASIAVYASRASQSPISAGIVVWISISTVLLVSSLATFLIGAYAVGRLRQQETGDDPWIEMHRLARALPPRPNPAEKGGDNKADKKSKALAEEDKAATEEAWKKFADDQEQLRKYVEKLEQEILDIKEKREEEEQGVLYAAAQQQQLQATNGQQQHQQQHELHPIGTAISTGDHTPDSKCNSSHKQPTVEDCPDCPSHHQPSEDEEDTTLTPKASKSTQTAANPRRDSLIADNKPTYYTSGGGHRRRRPRSNTTGTATQSLHRLIGPPSEFSSTGFGVPASNSGGTIGSLNLHIHHGYYSPSRNGHHSGHGGHHNYGHNHNHNHNHNHGDHILPNHTHTAYMTTPSGITMGVPISQTQSSILTELCEAVTLSGLSGSGSGTVGGIESYSPLGRDEISGAMRKAGVVNNNGVTPSPSPRPSQSPLGSSSVSGLGSSVPVPASVGTSSSASTSTGGASGAASGSEGKSTGMGTRTGYGMANGMPKGIMGGVRAVTASDVAPEEHEDHQQEAMPQMPQMPEMPEMPEMAKRHQQRQYLSPELELTTSSQKERAYYGTFRRMPSRREDVRGMEFFAGPNAPGDGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD80</accession>
    <name>A0AAE0JD80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_549898</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680503.1">
        <property type="nucleotide sequence ID" value="XM_062829697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD80"/>
    <dbReference type="GeneID" id="87866851"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000019">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="100"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="227"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3342710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="700" mass="78188" checksum="7646E5BB4CA27DBD" modified="2024-05-29" version="1">MGSVGTTLPHPFDPLSREEIENTIFTVKKAHGDVYFNVVSLQEPRKAEMTAWLEDPINAPRPKRLADVVVIAPGGKVYDGLVNPAKGEILSWEWAEGQQPIITMEELQIVEHIVRKDPKVIEQCKISGIPEEDMDKVYCDPWTIGYDERFGSSVRLQQALMYYRPELDNCQYQYPLDFCPIYDADKQEIIAIDIPKIRRPLSKAPAFDYHPAAIEARGGFRNNLKPINITQPEGVSFKLNGREIEWQNWKFHIGFNYREGIILNNITFNDQGNVRPIFYRLSLAEMVVPYGNPEHPHQRKHALDQGEYGAGYMANSLSLGCDCKGSIHYLDAEFPTRVGGVRNIKNAICIHEEDAGILFKHTDFRDDSVIVTRGRKLIVQQIFTAANYEYVVAWTFHQDGTIQPEIKLTGILNTYAMDPDEDTHGWGTQVYTGVNAHNHQHLFCLRIDANVDGPQNTVYVTDAVPGEAPVGSKENFYGNAFYNKRTKLATTGEAKTDYIAQTSRTWEICNPSKLNPYSKKPVSYKLVSREVPPLLPKEGSLVWKRAAFARHTVHVTKYRDDQLWPAGRHVPQTSGEPSRGLPEWIGDGTESIDNTNIVVWHTFGVTHFPAPEDFPVMPAEPMTLLLRPRNFFARNPVLDVPPSYASTPSQLLAKGAGVYDAADKLSKLAFEVPAGVDGEGVSGAGNGAGGSSCCKSGGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDH4</accession>
    <name>A0AAE0JDH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_241636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680954.1">
        <property type="nucleotide sequence ID" value="XM_062822332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDH4"/>
    <dbReference type="GeneID" id="87859486"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042073938" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3343161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19884" checksum="6421003266139651" modified="2024-05-29" version="1">MPGGKWWTWIRCHALSARLHATNCSSSPTRWSRKGGSGPGATTRLNLFAEVTRRQDASFFVQFQSLAAFQKHPNMYERSRRYAIFHHCSMPISTLFTNGHMGAKRMDMTRRTGSTVNTVCAQQKLVAGNTKRQLQSARPGATGPGPMWNPPKGVRPRANFLISIHVQYTRLLHFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDK3</accession>
    <name>A0AAE0JDK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_240199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680889.1">
        <property type="nucleotide sequence ID" value="XM_062822308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDK3"/>
    <dbReference type="GeneID" id="87859462"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000125">
        <property type="entry name" value="Intracellular beta-galactosidase BgaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="8">
        <location>
            <begin position="737"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3343096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1031" mass="117130" checksum="07F348870240C560" modified="2024-05-29" version="1">MASVYPSSIPDWNNNQVIHRNTLPPRSHFFLYPDSEKALTRDVSLAEAQLLSGEWKFNLSKSPLVGPVGFQQFDFFADPDWKPIQVPGMWQLQGFGKGPHYTNINYPFPVNTPHVPIDENECGRYVTYFQLAPEGKDHQLRLRFEGVDSAFTVWLNGKDVGYSQGSRNPSEFDITQYVNLEGDNILAVEVYQRCDGTYIEDQDQWWLSGIFRDVWIHKFPKKSHFKDVKVLPTLDNEYRNGKLSVTIELSSPEEVTLKLLDPAGGEVIQGTIEVSGEQSTVIELNIKNPLKWTAETPNLYTLLLTTPDCALTERVGFRRVELLHGVFSVNGNFIKLRGVNRHEHHPDFGRAVPYEWLKRDLLLMKQHNINAIRTSHYINDPRLYELADELGLWILDEADLECHGIFVVGGDGNKMLSDNPDWQEAYLDRARQMIMRDYNRPSIIIWSLGNESGYGSNHRAMYDYIKSVDTSRPIHYEGDWNAQSADIFSRMYASVDSMEGYAREPSWDKPFVLCEFAHAMGNGPGALKEYIELFYKWPRLMGGFVWEWANHGLRTKTADGEEYMAYGGDFGDEPNDSNFVLDGLCFSNHTPTPGLLEYKKAIEPVQTLNLENGNQVRIINRYDFVSLDHLKCFYYYSDDEPDWIEKREIKIPKGIKAHEQRLITVDGLLDAEALKAAGRHDCHLTLEFSLASATNWAEAGHIVATGQLPLTPPNNPFANLPPATGAQFDLLSPTLLSITSSNNTYEFDLSIGALTSWKRSPTTPNILTTPLQLCLYRPQTDNDHGCDFGRNWTSSRLTMAKHHLLSASWDNPSSPASSGSGSGSGPPTVTIQGRFAPPVLNWALETTTVYSFLEDGNIHVKLSGKPVGNWLPRAWARLGLEVGLRDVHSASWQGRGPGESYRDKKESQLIGSWTSTIDELWTEYEFPQEGGNRTDVRSVEFFSERWEMVLGARYLKPDNGKNTSFQASRYTVMDVEAARHPFELHRKRREDTIVHLDWMHHGLGTGSCGPETRPEYTLWADREYEVEVVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDS4</accession>
    <name>A0AAE0JDS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_510209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681117.1">
        <property type="nucleotide sequence ID" value="XM_062828376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDS4"/>
    <dbReference type="GeneID" id="87865530"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="395" mass="45214" checksum="74305881A564150D" modified="2024-05-29" version="1">MDIAALFAVFSETTSQPQSSVAAVATPEQEAKRQTQERNRLENLWYKEWMAMRGRYPRLFRGRIIVQDEQDEGGAYARAFQAAQSAGTHVNTPEATQVVIFSDASMDPHQHINTFAGVGVAFRRHDPSLAGAPNGMVEIWAGWPALNITSAETLALSFAIHVAMVELYRLEARLEVEERQEKEERKAREWEERRARKMAKLHRKLAKKERRKERDAKRSKERLREKKRERKERRMARREQKKLKRAAKFKQRRTKVTVKIFTDSTGALLMLDGQLPITTAGLRMSAMAAIEQSMELERRFINRAASSALMDVGLELHWVPGHSRRDGEARSLHKKADKEARSFDDWSRRCGSPVASEELEAYVSDLNGDLPECDEPAVSLLFEHIGELPQQPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE74</accession>
    <name>A0AAE0JE74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_428042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681001.1">
        <property type="nucleotide sequence ID" value="XM_062824726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE74"/>
    <dbReference type="GeneID" id="87861880"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3343208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="132" mass="13875" checksum="FE9EA9A2882985B8" modified="2024-05-29" version="1" fragment="single">MILSYEPLSILTGLTPLHCATMSQNLAIVKVLLASNADVTTRNARGQTALILASIIGSHDIVGSLLAHRSNISDKNALGTTSLIAAARGGHVDVVKLLVEGGADLNARDCLGRTALYEAAYYGQTDIVKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF12</accession>
    <name>A0AAE0JF12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_196909</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681779.1">
        <property type="nucleotide sequence ID" value="XM_062821732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF12"/>
    <dbReference type="GeneID" id="87858886"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="242"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3345166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="623" mass="68599" checksum="DE0F1C968A3BEBF8" modified="2024-05-29" version="1">MPSQKNANGEGHFPSRLKQFFRINSGSKDHKDRDANTTSSSHGGAPRADSKTPSGFRQSRFFSVGRLRSTTVVSEGNPLDESMSPTAHANPYFAHQGQPGLRHHGDGSVPPSPPDTPSLKVDGPEGSQQPTAATKEELARKLRRVASAPNAQGLFSKGQGNGERPATAELSKEPLEESKDSNTVGFAEQKPNNDSSTSLAAADADGLGALPPPIRQSPLAFRRTYSSNSIKVRNVEVGPQSFDKIKLIGKGDVGKVYLVKEKKSGRLYAMKVLSKKEMIKRNKIKRALAEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCSGGEFFRALQTRPGKCIPEDDARFYAAEVTAALEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLSKQSDPGGKPTMIVGKNGTSTSSLPTIDTKSCIANFRTNSFVGTEEYIAPEVIKGSGHTSAVDWWTLGILIYEMLYGTTPFKGKNRNATFANILREDIPFPDHAGAPQISNLCKSLIRKLLIKDENRRLGARAGASDIKTHPFFRTTQWALIRHMKPPIVPNQGRGIDTLNFRNVKESESVDFSGSRQMGLKGEPLESGMVTPGENAVDPFEEFNSVTLHHDGDEEYHSDAYEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF92</accession>
    <name>A0AAE0JF92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_189507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681526.1">
        <property type="nucleotide sequence ID" value="XM_062821616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF92"/>
    <dbReference type="GeneID" id="87858770"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="276" mass="31920" checksum="61941E9E4BB8CC86" modified="2024-05-29" version="1">MDQHQRPRLPFQRLTPAQERNAKFHKAHEHVHSCAKTNELGIQQIHLDAICPLGRPCSYQKCGHGAQHLQFVPCAATFETNKQMREHYRTHVRTMTKTLPDRTKELSCFFGSCASNPEGGRLNRGGPTFSTEEDRLAHMWEVHQVYAKWTANVELCNYCHTWLSEPYEWRKHAPTHITEAATIIEQHGYSGVTTGRTLMPRICPFCYHDETKPAHQRVYCHERQGYPKHIGVHFVDMDRTKKTRRCPCFPTFCSSQNEMDNSEIAASFEACSSYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFL0</accession>
    <name>A0AAE0JFL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_466751</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682080.1">
        <property type="nucleotide sequence ID" value="XM_062826875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFL0"/>
    <dbReference type="GeneID" id="87864029"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000065">
        <property type="entry name" value="GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="410"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="769"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3345467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="917" mass="100920" checksum="53B632F875F5C711" modified="2024-05-29" version="1">MSASEVQEGAAAAHEEVATKEVPKETVQEVTNEHEKEGEETETKNKDAQPDHQRPASLAPTDLSDTDDKDTDTFEDAIDTGSVRSLTKRSSSFNRPRSPSMDDSAADSDHDAVSHTTETPQVPKTTEDKEEEQEEVFETPAQAQESKSLHRISHASKVSEASAFSAASLDDVSLNDNSTIGDTEKTVDTAPSSTKKLSISSITSALPAMPWSPSATDEAVKSPPVAATVAAAAPPPPAPAALTPAPPPPVTRKLTSPFSWLSRSSSKEQTNPPPPPAATTGTRRNTASSVATLSSNPEGTLGKVDEENKNTLKDRFKQLRLREEGSAPTGDDEVKSSTSEEKEAVQPPPSPLPPTPNPALAPGTASGVTAGPAGSDAPVDWDLWQTVVYEGPAAVARTSPEQLKEAIAKGIPSAIRGVIWQVLAQSKNEELETVYRDLVARGTDKERKSDRQSNASISLSNGKASGKDTPSSASSVHSEKSGPNGTGAPSPSEKDSEAFVKAQALAAAERKMKEKEDKEMLSRLEKVIRRDLGARTSYSKFAAAQGLQEGLFGVCKAYALFDEGVGYAQGMNFLVMPLLFNMPEEEAFCLLVRLMNQYHLRELFIQDMPGLHKCLYQFERLLEDLEPALYCHLHRRGISPHLYATQWFLTLFAYRFPLQLVLRIYDLIFSEGLSAIIKFGIVLMQKNATALLGMSDMSQLTTFLKDRLFDVYIDATPSSNSILENGFFGSSSASIDKEVYRADQLVRDACDVKITAELLKEYGKEWEEKTKAEKEREQELQDLKKANTNYAVMVRRLEERIEAVDREQTSLATELVRTKVENEELKDENESLKGQVKELRVVIEHQPAELENKWNLERDDLMKRNEKVHEENLKLEKELADLEEQLVQTKLQYAEINSAHETLTRKWADLKRQVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFW5</accession>
    <name>A0AAE0JFW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_548679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681532.1">
        <property type="nucleotide sequence ID" value="XM_062829592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFW5"/>
    <dbReference type="GeneID" id="87866746"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="83" mass="8804" checksum="64A11B8A4D5A059C" modified="2024-05-29" version="1">MTLIKVTASKPSKAKWGCRKSSESSHRLNTYLQSDPTVTERLLNNSDLDGILGRIGSLQAEVNALAQSSRGSPSPSSGSADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGH6</accession>
    <name>A0AAE0JGH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_521422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682499.1">
        <property type="nucleotide sequence ID" value="XM_062828750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGH6"/>
    <dbReference type="GeneID" id="87865904"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="126443" checksum="70C497F7B366AEE0" modified="2024-05-29" version="1">MDPVSIIGIVAAACQFAELAAKGAIKGAGLLKSLKDTPAKLTELLGIVQTSRRNMVQLRDHLTHPILMSLSPQLQLQSFRDDIDQAYKVAEELELQIEALVGPPSQDLRGIKWLWRDVITVKKEGEFNDRFGTIQRYNEQIHRGLSGVQLALSTRNLRTTVAIGTRVDENTSVLAEIKDKVYAMNSRKADIDIDVNVHGSTLIGAQQTRASPATTRVELEVRLEPATARNELRSELMLLMTGQAPYASSANTLLPILSRLSHEDRAQVASMLVMNQLQHPNDPRRNSNFAPASGPPICGCNINTYKTGRAFRRGPFSFGYGYQNQKRHHTSCPYSGGQAVKQTWKYQLCMQLLPLVNKTVQFAFSATIGGGGLELRFPLKVFPTVQRASSAIFMLFDNFGERCAELDFLSMYYVNQRFYPLFHLNRSQPESNRHNNNGGVVWDIDRIRQELPYIHRVLCDGPSCKLPFFNTHCHFFLLVRAFITALPCIHCDSNLNKYTCTYLAMSHLHSSMLTTAASPLNSAIDAVRLSLPLFAQMLDSKEQPYLLVNSLLTIMSLDFDRSMVGGLPTNVRFYDMEKDSAGFDWNGRRGEVEMYASADAMDWAQTVVKSHVRKRTELATLGRQHLSLFDQKRLGLSSTEVTPLDAHAREVYDLLRKKEIQVPLALHPGWDGSIYCVLGTLSKEQHGIPHYWKFGNNIPVPTCAMVYDSFLLVAVAQQLFDNGFTVVDLPESSNIREQLKGASPNFPLAIYDNEQDFPGFHIRSSRSLLERLATGCGTQPYSHWSLMRLLVQYVSGLCPPMSTDSCVCYCLASDGCSPQHLHVSCDAYSQKCNRHEHNGNALVSWLESCFLTRDEKLLCFEQAVRLELFDRLGLVHTCCQTLHNGDGPPEPEDIEEIREDDEELASQLDLLMLAYRGSLLMFLKQQHEDEEYSTEFDCGCYEYEGLGKRPPSWGSHNLDAHTTRLLAHWRHWWSLTDPILTDIYGITKEDVDKAYDEGAFDIDRYSDWNEERRVIADMRSRLKLETMGFGDLDYKEVIEQHFSKKLTYARENINLVPGEDGNYWEKKFDEAAFVPVYRTELLDELMEKLRRAVSGQDEMWTRETEIWCKYHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGN0</accession>
    <name>A0AAE0JGN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Necrosis-inducing factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_460747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682635.1">
        <property type="nucleotide sequence ID" value="XM_062826557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGN0"/>
    <dbReference type="GeneID" id="87863711"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041955624" evidence="1">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="177" mass="19447" checksum="229D8C3291CBA8B7" modified="2024-05-29" version="1">MLVKTLIALIPSLAALASAAPALGAFKHDADHNDTNVLTKGDGLPHMLFHDCSGDKYVTKTTAASPLVEDCRYIADVIIPDFDHTPICWSWHDTIPREILSHGTCAVNIASKLDKYPNGDLIEMCNKDIQDFIHYSIDNFRWTTPDGRLVVGAEGYAYCPSDFPGHSSPAIYGLYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGN3</accession>
    <name>A0AAE0JGN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_443079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682378.1">
        <property type="nucleotide sequence ID" value="XM_062825613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGN3"/>
    <dbReference type="GeneID" id="87862767"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="228"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="813" mass="92041" checksum="D1819D820A27AA9E" modified="2024-05-29" version="1">MSQHEPHAVDVARNLPCARILLSFNPNIQSPSKLAMEVITGLSRRSPWMTCGAAEDIDASTSRHGPPFTSSLSLSTEAGVLHDCATGHLRRSMPFAITPPEPQPLGQLYTYQKLQTPGDIRTVTLFPGDFKDDIVIRISCAMLRLSNFNPTPQTRMTLEEVTATLPPGWTVGETWDNRYIFGRVDHGRREERLSRTSWSHPDSLMDPSGYVKSESDDDGHIMRAEPRYEALSYKYTWGSSAKPEVTFVWTDTRDTPAPIRAKKFKGPIPSGYTHLLIGINLAAAMRQLRHRDHHRILWIDALCINQLHILEGNAQVHRMSDIFRLAERVIFWLGERDRLTYSAKTWLAIKKLLSRPWFTRQWIVQEIRLAKPSNTIIRCGRSETSFTHFRSAIANLYIKSSLHPCLPRSLLLLDLVRPENGRTPLSDVLLYLGKSGYADMRDRVLGLHGLLSPVFKEKLRPDYSKSVYQVYRETFLAYSGHAKRLGLLQKCYLNKSETLKKSPSWMLDLSDLSVPTIVKHQFAAGFSRCYTKLVPESPNVLTVMGVRCTTIKTIRDPFPKKSKELLRAVRDHTARELAENEGSTYVTGEPFKTAFSKTVCCNYLHQRLTDVVWYPTLESWLWQDSAHAFFGPRAQLPSPKPSAITDCETNKSSNWYEADLETRLWHRRYVTTHEGFIGIGPPDVQEGDIICVFLGFDTPVVLRPLPRSPSRPPLQPLSGPSTSPLAVASTSDKYLFVGPVVIYGLHDSLSLLGPLPTPWRVIRKDGICAGHDDSAVFQRFRNQVTGDIITHDPRMSPEVLRARDVPIREFVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH28</accession>
    <name>A0AAE0JH28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_155223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682845.1">
        <property type="nucleotide sequence ID" value="XM_062821138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH28"/>
    <dbReference type="GeneID" id="87858292"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="240" mass="26911" checksum="FD66C1D5F8FA13A5" modified="2024-05-29" version="1">MSTPSPTGCTHHQDAWIRLFSFRDMNIKLRLFLFSSSCSFVHPRQDNPSFFLQSSYPSYSSWRAGQASMSVAMSEPMDAVPIPEPDIPPVSISHGTIQSLHPQAPTTNNLRIPPPEQTSQGATVARTLRSTTIRPTPFKLPPLPTYNCSMGPNPTESVAGGPPFWDVADMPSEWHPPPPRDRRPFPRAPNFLDQEDATGHGIRGQVCGRWLRDWDKLNHNHRSRSDNERHLRQKAMSIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH91</accession>
    <name>A0AAE0JH91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sec23/Sec24 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_441099</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682556.1">
        <property type="nucleotide sequence ID" value="XM_062825501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH91"/>
    <dbReference type="GeneID" id="87862655"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="309"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="388"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="642"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="738"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="870"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3347474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1112" mass="121480" checksum="AA5F9B4D10B7EED7" modified="2024-05-29" version="1">MADYSMYHALGQGETLDPNDPNRTTQPAPPQFQPPVAPNPYHPGAEYNEQQQQQQYGQQYGQQYGQQQQYGAPSPYGAPPPHSPMAPMDDLGLATQMGGMSLGAGAGAEHHGRKKKKDRHAFHAVEAPAGSSQPFNGIPPAGTAATQFLNADPSLAGRIPGQGYGQFPMPASPAFSPVPTSAAEFAARDATQGVGSGVFAAGGPQGGKPSPDDTPSVPLSRDSVQPYFHTNVYPTFERLVPPPAVTSFVALDQGNSSPKFARLTMTNLPASAEGLKSTGLPLGLLLQPLAETQPGELPIPVLDFGEQGPPRCHRCRAYMNPFMMFKAGGNKFVCNLCTYANDTPPEYFCALSPQGVRVDRDQRPELTRGTVEFVVPKEYWTKEPVGMRYLFVIDVTQESYNKGFLESFCEGILSALYGGSEEGEEQDESGEPKRKIPAGAKVGFVTFDQEIHFYNVSPALEQAQMIVMPDIEDPFLPLSDGLFVDPYESKAVISSLLTRLPQMFSNIKNPEPAMLSALNAAVAALEKTGGKVFCSLAALPTWGPGRLFMRDDGKHPGGEPDKKLFTTEHPGWRKLAEKMVSLGVGADFFMASPSGGYLDIATIGHVTSTTGGETFFYPNFVVQRDSTKLSLEIHHAVRRETGYAALMKVRCSNGLQVNAYHGNFIQHTFGADLEIGVIDADKALAVTFGYDGKLDSKLDAHFQAALLYTTASGQRRVRCINVIAGVSDQARDCLKFIDQDAIVSILAKEASTKLSTTSANLKEVRSSLTEKTIDILALYRKNHLAVPHPPQQLVMPERLKEFAMYVLGMLKCRAFKGGNETTDRRVHDMRLIRSMGARELSLYLYPRMIPLHSLQPEDGYPDATTGHLRMPSALRASFARVEPGGVYLVDNGQVCLLWMHAQTAPALIQDLFGEDKTTLQSLDPYTSTIPVLETHLNAQTRNIIEYMRTVRGSKGLTIQLARQGIDGAEFEFARMLVEDRNNEAQSYVDWLVHVHKGVQLELTRYNLSAMAVLGHRNDGAVYTYIPTPSTFMDPITVALTLSGFVTGVGHWIERKVLLLPRCFFPDCAASCFFQTVEALTGFIFTPHRPAGFAVRCCVASQLFMHRRGGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHC3</accession>
    <name>A0AAE0JHC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_547493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682763.1">
        <property type="nucleotide sequence ID" value="XM_062829522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHC3"/>
    <dbReference type="GeneID" id="87866676"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26078" checksum="8A368E7AD81177D9" modified="2024-05-29" version="1">MIKAVRDFTEYCEDDKAAVILTAERAVVGAVDSWILFLFYDGPEPSKEVFQNFTDIGAVLNTARKRSFADMIAWSNWVVLPGFNVLGGTETIPLPDASKAETVLGDIHAHWRPVPKRIVQKARERSPDLIGMDDSVDRLIMEVNFIFLLPSDYEKMQGVMKETYSGIREKVVGWQKDGTLPDAYVPILMSYGNSQQDYFARLKPESRALAKSVASKVDPKGLFRDRTGGWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHP2</accession>
    <name>A0AAE0JHP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caspase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_462317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683154.1">
        <property type="nucleotide sequence ID" value="XM_062826633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHP2"/>
    <dbReference type="GeneID" id="87863787"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="132"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3348072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="426" mass="46979" checksum="C4379F38367D352C" modified="2024-05-29" version="1">MSGYPGAGYNGGGYVPPPQPQYGGYYPPQPAYNAYQQPPPQQQPYMGYHQPSPGPQQQQYWNPQQQTPTPQGYGNTPNSHYGRPDANMPTVNSNSYAHGNHQAPPPPPQAPQQFGYGAPADYAFRYSQCNGRHKALLIGINYFGQRGQLRGCINDVRNMSSYLVEHFGYKREDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEEDGYDEVIYPVDFRQVGHITDDEMHRIMVTPLQAGVRLTAIFDSCHSGTALDLPYIYSTQGILKEPNLAKEAGQGLLGAISSYSQGDLYGVANNIMGIFKKATGGGDAHARALATKTSPADVVMFSGSKDDQTSADATIASQATGAMSWAFINALKKNPQQSYVQLLNSIRDELQTRYTQKPQLSCSHPLDTNLLFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIG7</accession>
    <name>A0AAE0JIG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_176606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683547.1">
        <property type="nucleotide sequence ID" value="XM_062821447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIG7"/>
    <dbReference type="GeneID" id="87858601"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="249" mass="27996" checksum="2C13D40CFAFA82C6" modified="2024-05-29" version="1">MAPGRLRRDDSNSASDADDVSPRLLRGHDLVSDTPNAATQCKLTVYFPPPSVVSLDGKIGHVVVKLDPAPLRWHGIQGILTLLRAKPDEDDILEDTLMAAGEWKAHRKRDDSQQCDQIGPCILNQGLQEVAPYPVPTGYNAHPFYFVFQDVQIFNPQNFHGPPIKMKFKVKVEGCNTGVPVEDASVCLVECDTMSSVWISEDKNITKEQREYTKEEYEKLKDLHFDVGSGTWVKLDSNKDDSNWVWRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIU6</accession>
    <name>A0AAE0JIU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_572368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683543.1">
        <property type="nucleotide sequence ID" value="XM_062830507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIU6"/>
    <dbReference type="GeneID" id="87867661"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="33058" checksum="3AE03CC7167AF14F" modified="2024-05-29" version="1">MAGNLTRLWWSPLDTGIRGLLDRDLQLVCSPLLVKFLIGPSKREYHLSKSLIASLSDPLHGILSEHKNSGRGGVNAKPVDWSNFIDEDIFNLFVQYAYTGDYKIQIMSFPEQDILRKHQRYSEARRINQDAFWIYESSPFVQTPSPASVYRQYAQIWAFAKFHKIQWLVVVAYKHLRTAFQVLMRRSTPGDCLGLEEKICREVVDVIGFIYHQGRRFWDEEIHPDAHEGMRSMIACFARKYLCDYDIHTMAGSRNLKMWTSLLEKEPRIAVDMVTHNAKTIPWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJQ8</accession>
    <name>A0AAE0JJQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_419151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683948.1">
        <property type="nucleotide sequence ID" value="XM_062824190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJQ8"/>
    <dbReference type="GeneID" id="87861344"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="284" mass="31017" checksum="90D4C4882A72E796" modified="2024-05-29" version="1">MPQTRIPQPEDFEALKSSSGLHVSLHYPTPPESTTSILLLFHGLGDSDAPFLSFARNLSLPGVLAISVRGIAPLPPSLLGLPLDSGPTNNFHWGDDLKLDGRTGEIDMDSGYEKVWEVVMNKLIGEVLMGKCGWELGDVLLFGFGQGGGVALGLGSKVRIWEVVGGDEEPKVREVKEGEEVKEGVVETTKKEKAFKGIVSIGGALPPSMIPSISAREKAKTPVLVLHGSESEYVGEDEVDLIKREFENVKVVEWKRPDDGMPRSREEVLPMMEFFAERLKSGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJU1</accession>
    <name>A0AAE0JJU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-repressible protein grg-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_456402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684224.1">
        <property type="nucleotide sequence ID" value="XM_062826290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJU1"/>
    <dbReference type="GeneID" id="87863444"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="71" mass="7322" checksum="92A0363A34FB58F5" modified="2024-05-29" version="1">MDTIKNAANYVGDKVQGATATASKEANKDVAKDSNQGVGTRLNAAGDAISDKVSENKHDAKAEAHKQGATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK73</accession>
    <name>A0AAE0JK73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_112971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684570.1">
        <property type="nucleotide sequence ID" value="XM_062820604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK73"/>
    <dbReference type="GeneID" id="87857758"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042130717" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8072" checksum="5A80B058E81C3B4B" modified="2024-05-29" version="1">MSSLLTFLLLLPDHLPLQLCSAATIPHGRYQTNGENPLLQLGLFAPIPTNLSCRSGATHPTHPPAILLLHLYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKA9</accession>
    <name>A0AAE0JKA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CDC23 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_519246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684504.1">
        <property type="nucleotide sequence ID" value="XM_062828714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKA9"/>
    <dbReference type="GeneID" id="87865868"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="11"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="441"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="704"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="769" mass="85197" checksum="93E8C4C554FCC3AA" modified="2024-05-29" version="1">MRLSAIDTLHLKEALQNAVVKCSERCLYQSAKWAAELLDSVPDPVLSDLDQEAAAGLQGYQHPAFSSNPDPVEAELEAKELSKYLLAKSFFDCKEFDRCASVFLPDSLLSGLLSTKANDATTPKGKGKASAAPSFEQALPSLSQKSLFLALYAKVISGEKKKNEESEMIMGPQDLGTIKNSHLVIVSRFLERWFAERKAEDSDLPPSQGFLEYLYGMVSVKEKNEDAAFDYLLNSVHLFPWNWGAWLELTNLISGVEQLNKITPVLPQNIMSFIFYANTAVNLYQQGQDLAASVNDLLKLFPTSSFILTCRALLNYHSKDLYTAEQNFSNLLALHPHRLDSLDHYSNILYVLNMRPKLAFLAHLCSSIDKFRPESCVVIGNYYSLLSLHEKAVQYFRRALTLDRSCLSAWTLMGHEYVELKNTHAAIESYRRAVDVNRRDYRAWYGLGQTYEVLEMNAYALYYYKKAAGLRPWDGKMWQAVGSCLQKMGKDRDGIKALKRALLADSYYDSTLSSFGSAGPADRMAQMDPEVLLQIATMYDRLGEVEEARAYMELCVAQEDGGATENVDASAVGTSNHGESFVVHGDSPGSDGDAEGGYEGRGGAGQGEGTGVTVATSKARMWLARYAMKTEDYVTANRLATELCQDGVEVEEAKALIRERPPSLAFPNIEEYLPSAAMISIGSNGGGGPRLRRVPRSGRYHEYVDTIPPMTDHGSGIYEDRSQESDGDENGGNDRYDDWFGEGYLADGYDDDDLDNDDDDDNGGAPTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKB7</accession>
    <name>A0AAE0JKB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_537201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684281.1">
        <property type="nucleotide sequence ID" value="XM_062829068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKB7"/>
    <dbReference type="GeneID" id="87866222"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000023">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="421"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="620"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3350986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1193" mass="132126" checksum="4450408612A16C4D" modified="2024-05-29" version="1">MVAQGGKYVPRQRKRKQLDRQRSRSKGTQDPEDTNALEIAPGQDTTTDAEKKKAQLREELRPEGVQVSSKKAKRLEKYIDAKLKKDENRELLAKLAANKIDTTLFSSTKSLGQTKLTKKEELSRLVREAKAGLITEKEAAKKLYEKREVKEGAPVPQPKPAAVDEDSEGSEDEQDSTAEKTKTTLAATIEPTPTQATTTTTSVPVPVGAGLKRPLEVDESGRPILAKRQKRGGVKTKHNFTSSQAPAVIPVPEVVEWDGFSSEGEEGSDDEESEGSGSGSVEEGSEEEEDDDEESGEEDGSEEEEEGSEEDSDDDGSAEESDEDMEDAEEDKKAKSSAFKAWAHQARNEALGYKPAESSILEIPKPANFTPRPVEQEPLPIELQPTKNDSRKAFAVVVTRTPEIQETRFRLPVVAEEQKIMEAIHDNDIVIICGATGSGKTTQVPQFLFESGYGVPDGPTPGMIGVTQPRRVAAVSMSKRVGEEMGDYSHVVSYQIRFEGTVDSKTAIKFMTDGVLLREAAIDIALRKYSAIIIDEAHERSVNTDILIAMLSRVVKLRRELAEEDPTIKPLKLVIMSATLRVEEFTQNSNLFHTTPRIIEVEGREHSVTMHFAKKTNHDYVDEAFRKICRGHRKLPPGGMLVFMTGQGEIAQLSKRLKARFGGGMNTASTTKVRISANEAPMEVEDIDFGEVDDDRNINDRDDDDISIASDEEEDKEFEIEDEESGTGPLKMHILPLFSLLPTKEQMKVFEPPPEGHRLVILATNVAETSLTIPGIKYVFDTGRSKERKYDPVSGVQSFEIGWISKASAKQRAGRAGRTGPGHCWRLYSSAVYERDFPEFSEPELLRMPIEGVVLQLKSMNLQHVVNFPFPTPPPRESLIKAEKLLTYLNAISQTGQVTPIGSTMSIFPLSPRFARILLIGHLHDCLPYTVALVAGLSAGEIYIPENQAIPAASVQESKKNDDGSDDDEDNRGAVTFRTTEDVLADDRRAKIRAAFNAAHKNFCYLDDKSDAIKLLQVVGEFAHDPTESWCDSHFVRFKVLKEIKQLQKQLTDLLRTNIPAFANLSVPDTLDPPSQKQVQALKQMVAAGFIDQVAIRADKAPTPPEMYRKPKRAIDVPYLPLIPLEGEDGHKLELEEKLVYIHPSSPLAHLSVDECPDYIVYAYLQKAGNTGADGQKRAKTRMHALTDLTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKF4</accession>
    <name>A0AAE0JKF4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">B0H65DRAFT_567881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKF4"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1138" mass="122320" checksum="8EB397133CC924E5" modified="2024-05-29" version="1">MPGGPATAGLSAAVGQWTKFLARAEAKRLDPSDFARFVPILNADFYPLPPIIIANLLLKPTKQSSYSLDPRRLQYLTILLNQKLVNPQSVLKVLHHYSTSQAKIQSEHDAGTTNDAATANKDQKGDKKPKRVFWQNSYNDEEIIFLRLSKVITHGQGIRHASDAYEMATNLSKWITLFIDVIAAFSRDTFGTIQDMRTKQDMETSLQAFSLLLVNFLGNQRVVSAFSRPEAKGHRKRLASSIDQLIPYILQNPNTSGIAEKLEFSRGQALAGEESSDLKDAAVAEMHSYMDNMIGLDTWQIPDMPLVNSRAGLYIYINAALVGRPLIDDHSLYTYLHNRYQGDLQTTAIHLILASFDVLANAVFRYEGSKTGHLLKSYVVNKVPLILGNFAASSTHMYPFDAEFCISQALGQVDTNVFPTLSNMFDMSNTSSSFQDSVRQDFCFACQLHGLLSSSAIETLLGEITYQTLPDEGRYVKETLVQACLEDSERSQRLIGELDNMNGNVGAAAQAIVEVIGTLCRNKETMTLKQLCSQLASKPSSLDILLLFDKPYKILHPLCELLDNWGGYDEDQGEYQPVYEEFGSILLLLLAFVHRYSLTPTDLAIRSPDSFVGKLLGRGSLSRPLDELSDQEKSHLNGWVHGLFDSEAGGLGDDLMSSCPPQDFYLLMPTLFDQIVMALSTGCLNDYLLRSGLEYLLDTLLLPSLVPALLFLANNLRTDKQAGQGAVIKILQLILRPNSISNEASTMLSSVLNIVAKPLELSLRSYQRQVPASQEVEPLLRALKENLAVSGRTGGADHSELENWTGTHHNGSGSVGGLYGAIRHAVQNLVQWAQHSPGNGVPTTYTHRQVLVALQICGARRLLSALLEELKAQTEAGNGPVAYDVVTAIICAPDVHNTPVMDDDPSTRGGGDSNNHPVLKRQRRITLREALKFEAEEFKKIQKSDPLMAETVVRLHRRVEAQMALPPPPPPPAQHHHHHQQTMLQPELSALGVVAGDAMGDSIMNAAAVAVSSGDHHHSVDAMSLDAAGMGGLDVGGAGGMDLSGMGDMGMGGMGGLTVNTSTGGVGGGVGAGAQSGGGAGGGAGAAGNGAGGAGGAGGGGSGSGGAGGDLSGDDIFSGLGTGDFTTDFGNWDTMDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKJ8</accession>
    <name>A0AAE0JKJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_107985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684388.1">
        <property type="nucleotide sequence ID" value="XM_062820522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKJ8"/>
    <dbReference type="GeneID" id="87857676"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="261" mass="29926" checksum="E54A6AF08C0B198D" modified="2024-05-29" version="1">MSWAGFKKNVNRATTQVMMKTGHVEKTNDRDYEVEERRFKTMEAASLRLQKEAKGYLDSLRAMTASQMRIAETIDAFYGDAGAKDGVSRSYKQAVEDLDAETIKALDGPYRTTVLEPISRFCAYFPDVNECIKKRGHKLLDYDALRAKVKKLVEKPDKDVTKLPRAEKEMEMAKGAYEQLNEQLCTELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDPDTREQYAQGQLDTRVEQVLQEIRELSISGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL61</accession>
    <name>A0AAE0JL61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_130820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684984.1">
        <property type="nucleotide sequence ID" value="XM_062820800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857954"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1561" mass="168466" checksum="D8A40EA9A7F16E93" modified="2024-05-29" version="1">MASQRPGLGPSGLSADSRLKSPGTIAPPGSLLLKKRGGESSTERVRTLPQPKMPSRLPQSLPQRRPSDTQPEPIQPRPTAGNRNSKILGNTTSITSASSSRLPAPTSKPRNVLRRKNSGISNEVVNSIRKDSRDETGNHSKTSSSSSSSNPRSQTSIDSSASSRSERNPTINTMEVRVAHQVEVAVGAPQAPALYPELDRYRDVKVPAYNGSFGIEVLYPLTTHDLPPPTPLFSGSSSQMSGFSSSPCTGFSGSPGPGPYSRDTTPTSMSSQSPGMVAPLRFPGAGVRMRQVDLTQTRPPVSRRRGGSISNELDLVSADPQGLPSVRESLTSSSSNSTVRELERKDSKKRKQLSPLPPSPPSRISSHKFTKSHDGSLSPPRPWRAPPTQPTAPAAVGAQLLPKPGSFSRPRPAQTAQQVPPPRGQPPRRPSRDGTPDLNSQLGLPVPVIQSNLTFAPSEKRSSKLLAPAIVARPGLLSSTSDTHVHLLRPAIAREATPAPKMSRMVDDASTIKAEPGRTTRTPSPGVSTFRRFPLFGRRTKTAPEVPLQKDEKKPTRKGPAAGTGHEGYGRVGPARRRSNSLANTSRAIPGTMSSQESIGTNDSFLLERMAPVVIAGGEIIENRNVGSDLSRTGSSQSVTREPPSVESQNGSQVSLNSIPRNTLWPSAFPRAGQHAQSASVSSRRPSESSESETPVIKSTLALRRSIQRLKSGEKEPPRIPAPIVTQPHVTSPSITSIDAGVLMTDDSMMAPSIDAAQGIKASEGSKNLSGPKRLMKRARSPRKWNFFGRNHSQPAPETKKVDISENAAPVAAVAATVKVVQSKPLAFYTMMDSSEQEDTDIPDLEEVLREAKSPDSPTHKQIPDSQNRESEECRPSVTQENTHPSFLTSEASAQVPTVAELEHMSPVKFSKLPTPPSMPSSVATQAGNTTSPAQGRPSRLPQVGRIPKVISARAEQISPKSFSRPFHRLSVQATPSKMDLRDAYSIAKGPSPSPPRPSTPVPMEPATTAGMEAPMLTQSPGSMLPTYPTQIGQEFLSFSPRKGSQCTTNTTTSSSSGGFNFAEATAVIPEPDAPLAEDEIWDEYDDLFGDETLKQPPSTRSSFGNQFHLEKYTATPTRRIEPPLESPTLRSQFQEQQVQSLTQIMHSERIPVSSSVYSSDMAEKVKQLLADHPSPRCSLEPDMSRESEMQLQNEAVSKQSELEQELETEKQTSSLPVDDPRRSDSSGCSQSSEDGSPLALVNLRVGSMTVSKWLTFGHVLFSPVRDELLNDMGSLKRPSILVIDGLGNDDWSFYAAETYPAATFFNLSPRPPRPAARNGSTGLPLSPPNHYQTRYMSHTGKFPFGAESFTAVVFRFPAAAPEAHYRNIISEARRVLKPGGYIELSILDVDLNNMGNRGRKAVRHLKERINAKSPDVSLGSTSDLILRLLGRKGFADLKTCRVGVPVASVIPRSSGSENGKRSKAAGKGKTIKDERTLPEMISDGSPVADESITKMVAKVGRWWYSRCYESAAGTDIGPGTLGSMWRDKALLAECEEWGTSLKLMVCHARAPDGRPRLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLM7</accession>
    <name>A0AAE0JLM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_130974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684988.1">
        <property type="nucleotide sequence ID" value="XM_062820803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLM7"/>
    <dbReference type="GeneID" id="87857957"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="244" mass="25975" checksum="FBC9EB54AAD03B64" modified="2024-05-29" version="1">MADRFPSLEEFDSGAQTEIKEGSGSPSASNFLEREKALLGDDANQFATVEDAGFDDDNDLLGGGLDSSAGAGAGIETDAAFESQFPDLSAGNESVAPGGTITGAGPSVTYNSGYAPYAEQEQEPEVIREWREKRDAQLAKRAEQFAAQRAETIAEAQQNIDEFYENYNNKKEKAIAQTRKEADEFLASREDTTSGGTSWERIAKLVDVSGKGAKGGAAGSGKERFRELLISLKKDEKAPGASGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLP7</accession>
    <name>A0AAE0JLP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_139440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685210.1">
        <property type="nucleotide sequence ID" value="XM_062820909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLP7"/>
    <dbReference type="GeneID" id="87858063"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="183" mass="20822" checksum="31C480468802995B" modified="2024-05-29" version="1">MPSGLKTPSWSWLTIEGPKSFPAIRISSWLNYRLAHVIDSTTQPVTMSKHHIGEVEKETTITLKGYVRRAVRVDGRIKEKGPFHSGGSVHFSEATSPLIYWDDPPADGDAFLFLLIMSYEHRFSSYTHYYGLILSFAHCGENDGKTCDHYRRVGMFRETFRMPQNEGGTRFDEGAQKEVVTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLS6</accession>
    <name>A0AAE0JLS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_587163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685289.1">
        <property type="nucleotide sequence ID" value="XM_062830964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLS6"/>
    <dbReference type="GeneID" id="87868118"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="276" mass="30425" checksum="5FFBEB752563FF66" modified="2024-05-29" version="1">MAARGLDMITKFAIPATVGVALLQNSIYDVKGGSRAVIFDRIAGVKETVVNEGTHFLIPWLQKAIVFDVRTKPRIIPTTTGSKDLQMVSLTLRVLHRPEVQALPKIYQNLGQDYDERVLPSIGNEVLKSIVAQFDAAELITQREAVSQRIRADLVKRAAEFNIALEDVSITHMTFGKEFTKAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESAETISKAINKAGDGLIQIRKIEASREIAQVLASNPNVAYLPGGNKGTNLLMNVGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMB0</accession>
    <name>A0AAE0JMB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING zinc finger-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_504246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685480.1">
        <property type="nucleotide sequence ID" value="XM_062827893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMB0"/>
    <dbReference type="GeneID" id="87865047"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="393"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="453" mass="49997" checksum="9C8164C326F0961A" modified="2024-05-29" version="1">MPPRTSLTSSFSITDANNEVVCPLRNQDGSSCRKRCIGEKRYRSMQEHIRRAHPEHYISKLPATEESFLLMIKTQPNERPQNQPTSGPSTHAGQAKGLSHAYHRDGSSAPGTPRNGEEQYTGAALLPAAAALAQLHNHKMEQGWESDNDWHSDHEGKRRPRSSIELPPIHLTNADVTSAPYSGYDSGRPREILPSILSNSPPGRSSTLPPLHRTLGPTRTRRQSISKRGHQSKRSKGATSEWLRRLQNDSQHELLRPGGSDRKALSAEPSADFGKRWEDLIDAATSATEDIDEDRTPVSSQGPSKFNPHLTSQIPRSPVSIHRSSLPPLQQHHNYTSYQASPLQQALTPPSYNPEATDAFPSVESGESGENFHIGSRGLSDSSPSYSSQNTQIYCAACREVSLLRESYACTECICGLCRACVDVLMLEQGARRKCPNCATIGGRFKPFQLDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMI1</accession>
    <name>A0AAE0JMI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_131276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684997.1">
        <property type="nucleotide sequence ID" value="XM_062820809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMI1"/>
    <dbReference type="GeneID" id="87857963"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="87" mass="10060" checksum="C95A6CF2C054B656" modified="2024-05-29" version="1">MWAKIDCFLAVLARLPNLVLFFSFLFFSFREWYGGTRNWEVIVGQILGSEPASLLRGLVLLKGGKLGRSRWEGWHRTSRTKDEKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMR5</accession>
    <name>A0AAE0JMR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_416142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685839.1">
        <property type="nucleotide sequence ID" value="XM_062824029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMR5"/>
    <dbReference type="GeneID" id="87861183"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="85257" checksum="2D2100FB01BF4C65" modified="2024-05-29" version="1">MAGMSRTNSANAFMEGFSVCQANLGEALTWLPAMGTPELDEMINAFIPGPASIKDKRAHISMDFLSYSQRTGFNFKFYPVPSTSFASASTASPASSSQFVDSGYASSFNVSPIISDSSAWTQSPASFTSPASFDDATRIVKARSSTSATKKLTAPSSRQQPVDFANHPGMRIMTKDGRDVTNSASRGCKTKEQRDHAHLMRIIKACDACKKRKVRCDPSHKKRAASHTSPAATEPKPTKKQKKETAKAPPPAPVVETTPELLVTDNFENFDAAAFAVPSVEGTENVDDLFWNQYFNFDQDAFPDFASGTFDQFAPSQELFYQSTSSSSAASPSQVFTPETPVHTRPSPAIAIEPVISTAAPALPYLNPGVPHGTEYVDFNLYSPPADFSLDEELLGLGQQQSYAPFNSGYADQQYFGDASVVAHRTESRSSPSSPSVSSGVITSHQRLPLEVYGGLHGSGDLQTLSNVSPAVQTPGQLTVRQQQQQRRRQLASGNESRVILQNSDQHFVVIGPGTLPIPDSPPTQRPLSPALNVQNAPHDVSHKSVMNAGSTHLQQSPIALQSVNAGVLATTQHASSVEQQSRAETAARSSRLRSPVKSKSSVAQRQKQGFAGLPVDLPTTSRDVSSCGICHSAASNSTLLRTTTMASSPSSTTTTILPGRRESGDGEGFAKIGEKLSSYSTSASSSSQSSFFPLVVLGLVSCLVVTALRSYCSNNNNSWGGHLDPLNTLFIASMSLFSLWQRQSSRWSTDPDTDTTRCSSVQGLFGSSISRQAKTLVARNSALVRMVSGSRSIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMW3</accession>
    <name>A0AAE0JMW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_418235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685616.1">
        <property type="nucleotide sequence ID" value="XM_062824134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMW3"/>
    <dbReference type="GeneID" id="87861288"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042232741" description="DUF7492 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="3">
        <location>
            <begin position="25"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="531" mass="56413" checksum="A9143BCC950808D8" modified="2024-05-29" version="1">MKTYSLKDTGGLLVAALFAMVRLSAGHSWPEQVRRIAPNGTMVGPVGYSRAYQTGDNQYQLIHGLDSALLYMPERAVLTDQSYNVNYAMPKAAPGDWVAIQYNENGHVSLPESPQLNRVSPVNRGTIYLYGTTNNNLADVRFADVHLKWTADGTGGDKKGRLLATRHYDDGQCREPLNPATGDPAGIKAFRQANFKIPDIMGGRLMCQSDIKLPADLKIGQVYTIIWVWDWPQTRERGVAVSPYTFIEENKDAIVSVPEIYTGVVDINIVDPCDESLGEVKGPGCKGGGKTDVQFVETDFSKAAIRAQMANLFMVKVPQKGKAAKAGVDYNEADIPMAGLIGRTDRPNPIPYDIQARNMARQKSLFVQVGGSVNAPSASSHTGGGSVSASSSTASSATQTGSPPAGGVFLSASSSTAPAPAASSAPVSSASQASNSAPTSIPATVSQESSVSAPVSTNNPTEGNGQNPIAGNTKFVMVTQTITMPASTVYVTETTQIAIMTATIYETAYNQTTSAPKFRRGKGQWGFVGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNB0</accession>
    <name>A0AAE0JNB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_24357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686160.1">
        <property type="nucleotide sequence ID" value="XM_062822357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNB0"/>
    <dbReference type="GeneID" id="87859511"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="179" mass="19508" checksum="61E1F82DE3DCD193" modified="2024-05-29" version="1">MSSPASLTGTLASNASSAPDRQETYAVNLPVPVTATAPKATTKTAYLPPASAATSKPKYAQPPSPSSANATNMPTSNTPNPNLLGPTRTATVNFRRLSHLEMGDTNSVDINNIVSPHNHPIKEFFSVSVHTSDQPEEERERELGWRDAYEVMIKAPLRSLAQLARRMRRVRAEREEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNY1</accession>
    <name>A0AAE0JNY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_514821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686138.1">
        <property type="nucleotide sequence ID" value="XM_062828650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNY1"/>
    <dbReference type="GeneID" id="87865804"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042288355" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="448"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3354760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="686" mass="68115" checksum="B448D26418CF3457" modified="2024-05-29" version="1">MKYSASLLAFAASAAATFPFHNAPAFTCPQNTDNKCTDQQKTGFAFDDLSAGPFSQYMDFNFNGWTSGAGFGGRFGKRTFKGISGVCGSDKSKAPSFGAGDKFSLGSIHVTPEFDCDLEFHYHMPDGSTCKHRNQCTKGGTNVVNKQCGGATNVTIIYPPQPEKPKPSCSVIISTISFDCSTKQSTVPPKTKTTNGASTTSAAATSSVPSVPAETTSTSAAPVASSSAPAESVPGSQTSTAPAEITSAPSAPVESTPAENVPILTTSAPISEVVSAPPVTSTIVTSFDSTSTIFVTEIQTITSCAPTVTNCPATTTVVTIATSTTVCPVTETHTTVISATSSAAPVASSEGPSEIVISTSIGDIISAPAGSTSSAAAVESSAVASSAVASSAVASSAAVSSAVESSTGVVVPTSAGSVASSSAAAVDTTSSAAPVSTAPVEPLPCPGVVPSCLNTFLFETGCTDNSDAACYCPNALFVKNVYECIYAHGESESIISEAITFFQGICAPYVNTNPGIATGVPTYVTSTAAPTSVAPVFTTITVNLTTVVPCTDEAGSTIASSSTTVIVDTTMTVPQIHFTSTTDDVAIVPAPTGVPLVTETEAVPVVSATVTKTGAVGVSTSAAAPVNSAPAVTSAPAVPIGTAVGTGGLVRPSSSVISPPIVTAGSGRVNAGLGLAVAVVLGALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP75</accession>
    <name>A0AAE0JP75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_505094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686515.1">
        <property type="nucleotide sequence ID" value="XM_062827967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP75"/>
    <dbReference type="GeneID" id="87865121"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="31"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="714" mass="79896" checksum="4BD0E66077A7CBA4" modified="2024-05-29" version="1">MGNFASTCDRTRHYHQHGTKLTLEDRPSNLKIVIVGAGIGGLSAAIGLRRNGHEVRLFEQSAFASEAGAAVHLSPNSNGILRRWEFGANPMNRLIELLPNGQIVKDVDLIEFNKRWQHPWHLVHRVNLHERLKKLATSEEGDGIPTQLHTSSKVMDVDTAQGIIRLANGETVAADVIIGADGIYSTTRKYIKDAKLFSSGKAAFRFLIPRNIAEADPVAAPLVEHPNTMRIWYGDDRRIVMYPCNNNQLLNFVCTHPDTESHPTKSDEWNKQGSLEQVLKVFEAFDPAVKALIAKVDPSTLKVWQLLDMEKLPTLTKGKMVLLGDAGHPFTPHQGQGAGQAIEDAAALTIVLPRGTKPADVFERLKLYEAIRYERAHTIQNYSRLAGSDWINGKPQVEIELLTKATNYNFGHDEIDHSRNMFNKWLWSRNPNACWRMPIGFGPLPAPGPPSQQDRHAYFTSMIIRFKTSRTFLETLFPTAQFRFKEVSTVATASFAATRAHNSKHTTLRFYVHGVQYLKKDGTAVDGTYMSVVFESPAVFGTKEAGLLPKVLCDIELSTDNTSARVTVSWRGATFADITIDDLQDEEKTERNDEGVPWQEENKDEEVVLFYRYIPALDSPGKTATEYPCLIPRPACIGEEKPKSMKVTKVMRPRPESVRTGPTVKMDGHNWEKLPTLHHIASTLAEVPIYEIVDAKVIVGTGITDDSMSFMKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPD2</accession>
    <name>A0AAE0JPD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cryptococcal mannosyltransferase 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_515867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686619.1">
        <property type="nucleotide sequence ID" value="XM_062828662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPD2"/>
    <dbReference type="GeneID" id="87865816"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="359" mass="40804" checksum="F843358116335295" modified="2024-05-29" version="1">MNPEKNLPRFECPDFNPLRYEYLAVQDDDGDADSSGIQHFFALDLRECLHLLPRFIGSIVEAIRFFGPQSCALSIIEGNSHDGTAEVLEALRPELDALTKTYYFKSSDINPKQGARIQKLTELRNLALQPMLDPKNSKLYPAEANATVIFLNDVAACTDDILELVHQRRFLGADMTCAMDWTYVGRDPTFYDVWIARTLAAGDSFFEIPPDGNWNSAWNLFWNEPTARERFFAHQPFQVFSCWNGATAFTAKPFLEKKIAFRAPRKGECIQGEPQLLCKDLWWHGYGKIAVVPSVSLEYSDERGKQIKEARDFTTQLVGGEGHEDDAIQWQASPPEKVKCMSDYGHQFSKEWNKTQVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPY1</accession>
    <name>A0AAE0JPY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="9" type="ORF">B0H65DRAFT_44122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPY1"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="657" mass="72246" checksum="80A54C1ECD26E91B" modified="2024-05-29" version="1">MDSPLNLRPRPPNSRGPQTIADFIRRVNAEPGGFRALNEEEVRRNVIAERNGIHEDVEMVTDQEADDDSKKPDIIAARHNIVMNLGQAIQMSSNFLDFISLLLSKEIPTQAAVSISPWLRSQVPIGSIGATQLDAPTPLTQSRVADNKLITIGKRLVALNEAADTALAAANRLRQEINSETKYWQEVLTVSQKGWSTARLPQEPHDMAVKFGFSNAAPMFKNNSVAPLKRAEDGSVRLEYGRMGSRSERLQVTLLHNGEVIGRSPLPRPLPDHAPLDDRVKEARNTIFAQELWHEINREGRTLHGHHVRLEQSAVTCALDPNRSISFELVGLEDQDPSRAPLPGNLDAETASITLHLLLSNAHRQNQLKRSERTAPNAVRGPPPPYNLLLPIITYYRHEKTLEDCTTFLAAFCAALRSAGIQSSFSMTESINKGSPTAPPSEALMNTLLHPSEVQFDLTITPASRLRILAKPSPVFGTRFSIYLLHPQSNHLTSSFPPNQTDSVYENIKELVRYLSNAVPRALTMYYYPLVQEMRNSGNKGNNGEIPTPSATNTTTWIIHPDDLGLVDDDTETFGVRFAFVSNHTRGDAGGDGVDDAAATEPELRVTGDFMEDGKRVHNEWKWTALGAGAGQTGGSLDDIVKHILANGPSSSSVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQA0</accession>
    <name>A0AAE0JQA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_452207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686878.1">
        <property type="nucleotide sequence ID" value="XM_062826090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQA0"/>
    <dbReference type="GeneID" id="87863244"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042175805" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11144" checksum="2F468E5F7C1DC7A6" modified="2024-05-29" version="1">MTSSCLSAFISFIPLVIQQPSYLSSRCHPSIPLPSCWMRWFKSPSSQTATFHLRLETVHERSCFNMCVKLIWSLSLQHCNFALALHQLHQHCHPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQV4</accession>
    <name>A0AAE0JQV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_565129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687413.1">
        <property type="nucleotide sequence ID" value="XM_062830274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQV4"/>
    <dbReference type="GeneID" id="87867428"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3356036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="806" mass="91144" checksum="F1716D255A43C44A" modified="2024-05-29" version="1">MADPPVPQVHLKDPPLPPYHVYAIARLAGHYRCLGGVCCPSPYENTTKESVVLLLRRIFSDASNRIPLVLELELGSDIYARRGPPHSPPPSEEPCFPFIHTCLCVGSASLMEDAHFGESVFPLSADEILGNCPVGCSESLVPKEVGMSVIFIDVTDPSDIRHRFATWEPDLDPSLRSTKLEHLVTGWSLPLWSVVEMNTGLFTEQEKREVASASRIELGALKETWPGVIWNPDPSQRPVTLPPDRLTYARRREEWAMDPMVVTMAQVTWGELVRYEAPQPMGQRAATRLHIRLEMKKQKGKVVAWNDAVQLLRWAYRDEIFLDWACFAGLTARVVQLVLEYDPRAGGIPLASDRVLTLCPDWEKEEPKALAEAICSPKVVRFCDVYIMTLPEQAASVEICRKTGQLFEYLAENERRPTGKMLLTGAYSSSLHERFWLPQPSSLSVARRSPVLQFILHNWEYSPEGITGISSNTFQSYYLGDAFLTPVKVVNGLLDFIYQTHWTPDDDKLGPPWGDGLRLCICLSRASSTFDQDHERPQVQISPLPAEAYSIARTTSAFRVHPERYCQSESEPHPRYYSKLRDIDHDNWTLLLVQERHNAVEERLQPNGSSEMIPSMRLQLSYCFVRSSNPESRFSLTAKRCHPSDYVRGSTRWIGECPLSWLNLEATDMEGFLLNTMGPGVDITKLDARIDHYDERSAWALSTRGDVRHEDIWQILEVMSAEEARGALKRHSKNLKVTTEDMDRMRDRWSKVLLRPRWTLIWVLAGAGALKLCRGDNSVPFLQAPAPSAAINNTGALSSLLRLPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQW8</accession>
    <name>A0AAE0JQW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_545291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687444.1">
        <property type="nucleotide sequence ID" value="XM_062829365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQW8"/>
    <dbReference type="GeneID" id="87866519"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="147"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="902" mass="99818" checksum="492A409A91F32D88" modified="2024-05-29" version="1">MATTKTGNKQSHDEFHVCELRKYPVGPPQQPLALLELSLATSKQLLSRTFDFEPKYSGEDLLNQVKQLDAWTGDQLGFLDEALDKFLFKVLVHDTDTDTDTDTDTDTDTDTDTDTDTTTKPSNPTRLIKEEEKSSNLVPETQTIKSFVALSYCWHYPNWSVALGLQHGVDPTTIPDSPLAPAMFAAFLAERSSPEEPVWLDQWCIDQTNDEEKIVAIGAMDALYYSARVVVVCLEDVRLSPDDAAIILKFAEFVERKEKPEWKEDKEQVRLWTAVERIFAARWFIRAWCAHEYWMARQVVFLAPVTSDPEALPGEVGEVEIVRFDNRFLQLVHSVASNWFSGENAETFRRRERYRREAFEGEEAYYWGGRVPESNEEDAESFTKRRAFGIANNQHQMGDPEAKLLPQISSFAVIQSLAAGFERDKLSVWLNASRTRLFIKHNNPLSEAERSWIATVVSLASGDATVLAAVGPTLADRDSQHGQVGNKTPRETGWACVPEVDDYVHLGSSPIYPALDGNPSLSSDGLALDAIILDTSSGMQSPHHTSMAAAKGALKWYSEQRSKFPSSTETELGGWEDIDTITPLYTLHLTEALAILLELSDPPSFTWTRLCLSQAFPRPGSKYAKLLSHQSCVSFLEVGFLSLSGARSSLKAVVDGENDDDANLRAVEGYLNTFHSQNPDITFKGVTAFLAIAEGIVRTVCGGASYYRTGKVNETYQLQVSDAIPHGLIVFAPPASQFQQTKYTIACPLALSQLREVQVSYMHRGWILEQEEGNETVQEHPEGRKIPRYSLIGKNALFMPVGGSIIKHPETGGLCRMGDPVRFAASGVNRDGERRMVRRIVVGGGGGGEEETGELAEPGPGPGAVPELRFFLTSWPAAPEWPGAGSDSPFSAYVTPMAATTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQY1</accession>
    <name>A0AAE0JQY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_513620</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687521.1">
        <property type="nucleotide sequence ID" value="XM_062828634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQY1"/>
    <dbReference type="GeneID" id="87865788"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000695">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="527"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="218"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="581"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3356144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="609" mass="63796" checksum="2640CDF94202C2E5" modified="2024-05-29" version="1">MPRDDLSIDFVRKMPPAAELDPALILDEWIHNTQNLPEEIRFMQDEIAEKDRQYDKLVKEIDKNDERIQKFIKANGSFHPNPKEEEYRQTILKNFDLAEQLSKEKLELTRKLQHTFDKHLRALDKQIKSLYDRGEPGFTDPDELPSLVRDSAANITSTPTVLRPVNGNHPISSALNGLANGTGPNAARSNQIRNIQASHHHSASAPATPAATIILNQRARESSAGPGGAARKGAVRSNSGLNLQTSGIGRHSSLGPGTPKSSTASGGVQRAGSAGPRGTGKGSISSTSRKSVPSGSSAASRKKGSSAPTAGSGSGAGGGASANGTSGSGAGGGSGSHKSNLSRVLKRAGTGTSGSGAKNSPNSTSRANSTGDSDLSDADSNLSGSESDHRRIGTGRNTPIGGGGSHSRSASHHHTSSSFSHKGGDDPNHPHHHPGHHPSSSLASNNGSGLGGPGGHFPGRPLPTPSLHNPHQSSHNRNRSHHQLQEMHRSPSLSGHNPDDNPGLSDDDAMDLDDNMDLDDEEAGDDRKYCLCQNVSFGDMVACDNDECPYEWFHWSCVGLKSEPNGTWYCPVCAKNMEREGGRELGKKGSQGGGGNSSSQGGGEGGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR37</accession>
    <name>A0AAE0JR37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">B0H65DRAFT_439404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR37"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="778"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="521"/>
            <end position="537"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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        <location>
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            <end position="850"/>
        </location>
    </feature>
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            <end position="870"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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            <end position="889"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3356267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1000" mass="108172" checksum="613B3ADCA1020C4E" modified="2024-05-29" version="1">MAHNDTIDIISSSPEFPDIGALVAKAPPKTPALRTGSNAAPIPSDAVGLGNFTSAASIWRLSQVVEEEKPAQKSPPQPTKETRTIATSVSTVAVEVSTTTTAVSENKPGKKPRKPRKKKDETTATDENAPPKPPARRGRPPKQKDADGQTALPESKVTKPAAKPRASRKKAETASRHFAGSDHASTADAPVPEEPSKAPAAPKPPKPVPVRIDDEPVDLEPAVRRRLDWTPPPDDRPPPDDRPPAAAGNSSTVKELPSSTTAHIEPPVAFGKLLDTYGCKPENDQPSEVTKVDVLGKRKLIEMVATTTTTTTTTDKPTSPETSPTKPKAPKKKPRTITDLATAAYRIQDPVDDSTSTLTSKQDTLLGYIDVEDDKAATKPSGAKTKAASKKPAKPRVSKKKPEPRRQLLLSPKSALRQVSGQDFVFGTSSQLVTEDTDLLRALHESMKTAGNAPNSDPITSSPVKFSSLASRRKMGNNKLWKVGARDEDGDLLDLEVFDLTEAVEVPEDLLQQAHRPSVGVREDAKPGERVESKAETAIEIFPSDPVVPERPTVTRPETQISTLSTKGKESVLHTTKPPPQNPVAPPRARTHQRVRSPSRESSSSRLWSPRTKTPPRPTTPPRASAVLDFDFDFDDYEPPPSNQEHYQLLEQSQKSPSKTQQQRQQKTQQPQKRMDPPPRPKYELFTDAQLSREIASFGFKPIKKRAAMITLLEQCWESKTGAATGTSTGLGNDKLQEGTRSLESGHRSVDPIAVSPNRGRGQTMKDAAMHEAEAGIKIVAPAPKRPRGRPKKKEAAIASPPRTTSDKPPKAAAAGAAHRTAAASKPATAPLPVLSASTPKRQRRTSLSPIRTRPIILEIPDSDIDDSDSDPFASSPPASSPDASPSASQLFSTPEKHQDHEHDPAEMSLLTECEESLLDITSTPSEDDLFKHITEAITTAPRTTNPSEPSWHEKILMYDPIILEDLTGWLNTAGKGLDRVGWEGEAGTEEVFVGEMGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRM3</accession>
    <name>A0AAE0JRM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_414871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687097.1">
        <property type="nucleotide sequence ID" value="XM_062823950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRM3"/>
    <dbReference type="GeneID" id="87861104"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16965" checksum="F7D61D83DA7A7487" modified="2024-05-29" version="1">MFITPQESHSISVRAGQGDLAGLSVAVKTLAQREKVTEGEVLISCKDDFQRTAAHIAAQLGQRSSIETLAVLLGSQENKATYFNMANRFTGDRPAHTAMRFGYLDVLRTLVAHGADPTAKNRFGDTVLDYPGDYEMDEARSIVDEYRAKSPQTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRZ0</accession>
    <name>A0AAE0JRZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cortical protein marker for cell polarity-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_564896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687277.1">
        <property type="nucleotide sequence ID" value="XM_062830268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRZ0"/>
    <dbReference type="GeneID" id="87867422"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000127">
        <property type="entry name" value="Cellular morphogenesis protein (Rax2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042155880" evidence="3">
        <location>
            <begin position="36"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="5">
        <location>
            <begin position="242"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="6">
        <location>
            <begin position="402"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="4">
        <location>
            <begin position="920"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3355899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1249" mass="132395" checksum="DACABF7B44CEB28F" modified="2024-05-29" version="1">MRLPFRRRNDARGQSLSPIAVLLTLSSVALSPVTAISFTPAPATNLDLKDLGRVALAGDFSGISLFQFEEQNERPFITNGSQSLMARMPNGIFGPVVTTDATILTMCTFVEGNGKEDGVIIGGNFTSLQLPTHGSESPNYKESKAIALFNPNTSSIETLSGLEGQVYAVLCDRDTNSVYVGGNFVGKDSRNAIAWVGGQGWTDLPFRGFNGPVNSITKASNGHIIYGGSFTGLGNATAPTKRDGQVINLSSATISAGSSTTREGFSDPNNIVCSTSGTDGTGKTWLLQENSPGFWQATFRYGFRPTKLRLYNTHQDGAGTKTWRFTALPINGIMNMTYVDPVTNKNATCTSECPLSNNKTTKFQDFHFVNVIGMNEFRIDISDYYGSGGGLNGIELFGEDIFSYAINDFNEPTCANLEFKSSSTATGPWQVTPSHQSTAEYLTAQISAPITNTSAQVVFSPDIRESGYYSVNLYTPGCLQDDTCASRGQVHLTGQMTADPTKSDPVDKTLYQTNNFDKYDQIYYGMVDASSSSFRPQITLTPLAGQDLANITLVAQSIDFTLINSTGGLNGLFEYTPGRPVNVSDFTASAVNRLGSSFSGKSAVNALATSGDTVFVGGNFTSPSADHVVALNTKDSTNKTLDGGLNGEVKSMILDGTTLYVGGSFNSTSVKSVDGLNNVAAYDTEKNTWSPLGAGVNGNVMRVVGLTMNITGSTPEFVVSVNGDFDELNAFDKNPAVSVTGFGIWVPSQKNWVQNLDLQLESIDGVLSTSILDRSGNGSLYAGSLISSTLGVRDIAGFGDRLSGFPIKIQAPTKSSSSSSLAKRDGSVSDSSLQGVVTGIFDQENKRNLTILGGHFTATGSGSAINNLLIMDGQKNNEVSGLGDAISQDSTVMALAVHNDILFAGGNITGTVNGNEVKALVTYNLANKSFNPQPPSLTGGNGTVSSIAVRDDTDDVYVGGSFTQAGSLDCPGVCFFSTSSSQWQQAGQNLGGTVNTLLWVDENLLLAGGNLTINNTASTYLATYNPKTLVWDAYPDAGQLPGPVDVLTAGTSDNKQIWVSGTASNGSVYLMKSEKDDGSSWHSVGQTLQPGTKIRGLQIFQLSESHDKHPLIDDKAALMLTGHIVLPDFGSASGVLFDGANFRPFALTTNSGNSPGSLSTVFSEKQNFFGKDGKHLPLVFVVLIGLGISLALMLLIVVAGLILDRIRKKREGYVPAPTSMYDRGSGIQRIPPHELLEGLSKSRSGAPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JSH8</accession>
    <name>A0AAE0JSH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_71755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687606.1">
        <property type="nucleotide sequence ID" value="XM_062831318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JSH8"/>
    <dbReference type="GeneID" id="87868472"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3356229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="517" mass="57352" checksum="5D96BBA79585CBB2" modified="2024-05-29" version="1">MPPRRSHKKSRAGCRRCKSRKIKCDEVHPRCGNCVKHGVPCDFEHPEIIAELQAAQAASASSPSTAGTPYTPAYSPGAESVSNASTSRLQRAPPLCRSPPSQALSTTTPAAHRMLELRLMHQYTAMTCKTFTFTAPTTEDIWKITVPGMAFSGSQHLTDAILAVAALHLRSQSPNDKNLVRASHAYMAASLAEYSATLTKGIDSSNAESLFLTASLIAFQSTATRVFMKDELSLAQATGNYPEDFNKQGRYTAAGCYSIPFSWFHSFQGVKAVTAASWQWLRNSPVVTEVINSQAVLQLDFGPNRQTFFGHLLDGLDEELEEMANPSRPAPLHTDSPGQPFQQRRAPASPELVTRTRQAYQHAVAVLNWAHKIPHKGAPLAFPATVSKRFIETLEERRPRALAILACFFALLKSLDSIWWLHGMARREVLGVVSLFNSDFFGPEAYSKWWPHLEWAMRIALYETPDGSSTIPPEVWGADWYAEEQALESQGEHNYYRHIELLSQMTNPTKSIPVVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN05</accession>
    <name>A0AAE0MN05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nephrocystin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_434983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677556.1">
        <property type="nucleotide sequence ID" value="XM_062825170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN05"/>
    <dbReference type="GeneID" id="87862324"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="313" mass="35739" checksum="DE10CF3CCFFF716F" modified="2024-05-29" version="1" fragment="single">TRDCPETFGQEETFRQQYIERMAASFPTGQFENWAMCRTLFAHARVASDYRPSENTVESWAILLHNGGWYAWSQGRYEDAQQMLDKARKVRKRRLGKDDVATLSSTSLLASVFRDRGLWKVAEKLFVQVMETRKAKLGADHPSTLRSMANLASTYRNQGRWEEAEKLEVQVMETRKAKLGADHPHTLTSMGSLASTLWNQGRWDEAEKLEVQVMETSKAKLGADHPHTLTSMANLAFTWNSQGRHEDALALMQDCVEARQRVLGPEHPDTLSSLTAVSKWCEITNNESKRVYGWFLVCCPCYREKERLASLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN47</accession>
    <name>A0AAE0MN47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_479552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678048.1">
        <property type="nucleotide sequence ID" value="XM_062827533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN47"/>
    <dbReference type="GeneID" id="87864687"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042115570" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="210"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="550" mass="60673" checksum="B91D758617D2CBA8" modified="2024-05-29" version="1">MGSSSATTRLTWTPFVFSLLLLATAGCGHKANAHELPLSTHPLLRLQCPNLTLFHRHATSTHTATCPVPGLLGIFPDLNTDSNTNNLNLPWSFPPKCMTLASSSKKSSPASSYQSASSVSSTSSASSAYSSSSSSLSASASLENDESRGKEIPYCLFTSQPFRNGHGTSLIVSPNTASHLLGLGVFEDRPPPWKWIRQSSRSRSNEQQRTNLAYRIINVAGKGKGVVATRPIKQGEIIMVDYPALLISEEFLRETGREGKGHLRRRMVKRAIEQLPEITREKVWGLMRGPGKYEVDAIMGVNLKGLEGVGSGANSALALLEEPRTEEHGESYAAEGVMGLFAEVARINHSCRPNARLRFVENRATMEVISYRPISPGEEISISYTALTLSPSDRHHFLKQNHQFTCHCPLCTSLSDDPSAKTLTAESHSRRTHLQEVFDTMLHAKGEGFYQDAINILKDWLDFAEVEGLLPLMGEYHGTMAELYLLLAERGSPGDKEVDREGALRQALREARMAVDAWVKLRSVDGRKTEEARVFLEKVFKLKERRGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNF9</accession>
    <name>A0AAE0MNF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_288247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678393.1">
        <property type="nucleotide sequence ID" value="XM_062822971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNF9"/>
    <dbReference type="GeneID" id="87860125"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="89"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="282" mass="30486" checksum="721F59CEC9C402DF" modified="2024-05-29" version="1">MSSARLLSRVFQVSLRNQSRRSLTTRTVPTITSTLTSQATRSMAFSARVAAHEIPSIHDLYSKGVLPKEAFYAAESKQTLPVVVNGGPIALPIPSPELNKRLAIHNGDITKLQVDAIVNAANNSLLGGGGVDGAIHRAAGPQLLRECRTKRGCDTGDAVMTEAYNLPCMKVIHTVGPIYSSANHQECEKLLISCYLRSLQTAAEAGLTTIAFPAISTGVYGYPSRKAAQAALGAIRHFLLDPKTQNTITKVIIVTFVDQDTRAYHEWLPTYFPPSISEDGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP86</accession>
    <name>A0AAE0MP86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_432434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678424.1">
        <property type="nucleotide sequence ID" value="XM_062825006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP86"/>
    <dbReference type="GeneID" id="87862160"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3339064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="879" mass="99533" checksum="02EAA375687FFA0F" modified="2024-05-29" version="1">MATTKDEKAVNITPALSEKYDEKVGGVHEIGLDRIDSEEAQVLEGHLDVTEEDLLQAKAAAETLSLEDVVKLMKNVVSMHGRDPNFPHVVLEKIQEFLANEENILSNPEKHHEIITEMKIEAALIQSNSPYAEVRAVVDNTDDPSTPCSTIRSWTIGILFSVILAFVNQLFSVRQPSISIESNVAQLLAFPLGKAWEKWMPYYEFTLFGTKHNLNPGRFSKKEHMLIAIMANTAKSLPYTQYIVWTQVLPQYFNQPYANSFAYQILIALSTNFIGYGLAGITRRFIVYPSYCVWPASLVTIALNSALHHEENHTVPGPFKRLYSMSRFKFFMWAFGAMFVYFWFPNYLFEALTFFSWMTWIAPNNLNLNILTGFQNGTGMFNPFPTFDWNVMLFDAVDPLMVPAFTTFNKTFGMAFFGFIILGIWYTNVWNTGYLPINSNRVFDHHGSLYNVSRAINEKGMFDEAKYMDYSAAYLSAANTIVYFAFFAIYAATISHIILFHRAEIAIGFKNIWKAVKPKSWIKRNAAGESVEEEDIGYKDVHNRLMAVYPEVSELWYLGCLVIAMALGFAGVAAWPTYTTAGVVPYGLFLAIIFVIPIGIIKAMTGIEVTLNVLAEFIGGAWVEGNALAMNFFKSFGYVTCAHAISFANDLKLAHYIKIPPRHTFTAQMVATLISTLICTGVLNFQVNIENICQPNAPMRFFCPGINTFFTAAVLWGTIGPVKVFGIHGQYKWLLLGFPIGLCIPIIFWLVIRKFPRNKFIRQFHPVALFYGGLNWAPYSMSYCWPAVPIAWLSWIYVRNRYLAFWSKYNFVLSAAFSAGIAVSGIVMLFSVQWARVSVEWWGNTQPYTGCEDTACTIKTLSEGERFFPWWDATKVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ17</accession>
    <name>A0AAE0MQ17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B0H65DRAFT_269317</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679686.1">
        <property type="nucleotide sequence ID" value="XM_062822731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859885"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1102"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1145"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1180"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1210"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1249"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="232"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="327"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="1031"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="615"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="616"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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        <location>
            <position position="707"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="748"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="771"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="804"/>
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        <ligand>
            <name>ATP</name>
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            <position position="885"/>
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            <name>ATP</name>
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            <name>ATP</name>
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            <name>ATP</name>
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        <location>
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            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004166"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00034036"/>
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            <dbReference type="ARBA" id="ARBA00051303"/>
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            <dbReference type="PIRSR" id="PIRSR606539-1"/>
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            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF00122"/>
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            <dbReference type="Pfam" id="PF16209"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF16212"/>
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            <dbReference type="EMBL" id="KAK3340744.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
    <sequence length="1360" mass="152086" checksum="07352F252D4197B3" modified="2024-05-29" version="1">MAAGRPPPGAPSSAQHDDLLLDFGNEQPYYSGGQRSTLNDDDLLRLHSDDAQGAAQPRPSVSYDDFIGSGQTTQQTATRPIQPAPGATTGGGPTSPYPDSRSLDRHFSQTSDLGNYQRYAEDFDDYPDESTTSYYQHGGSIPPDSAAARDSARQRNSVLSMGGGLIGRAKSMLGMGSEGYSEMDLPLTDPRSTAPVDHSHEPPPQKPTKKFDFKFGFGGGKPDPATLGPRIIHLNNPPANSLNKYADNHVSTAKYNVATFLPKFLFEQFSKFANIFFLFTAGLQQIPGLSPTNRYTTIGPLAVVLLVSAGKELVEDYRRKQADKALNMSKARILRGSTFEETKWINVQVGDIIRVESEESFPADLVLLASSEPEGLCYIETANLDGETNLKIKQALPETSSMVSSSELSRLGGRIRSEQPNSSLYTYEATLTMQAGGGEKELPLNPEQLLLRGATLRNTPWVHGVVVFTGHETKLMRNATAAPIKRTKVERQLNTLVLFLVGILLVFSVVSTVGDLIQRKVEGEAGLAYLYLDPMNGASAIARIFIKDMVTYWVLFSALVPISLFVTIEMVKYWHGILINDDLDMYYDVNDTPANCRTSSLVEELGMVEFVFSDKTGTLTCNMMEYRQCSIAGIMYADKVPEDRIPSIEDGIENGIHDFKQLQKNLESHQSAQAIDQFLTLLAICHTVIPEQAEDGSIKYQAASPDEGALVDGAVQLGYRFVARKPRAVIIEANGQQLEYELLAVCEFNSTRKRMSTIYRCPDGKVRCYCKGADTVILERLNDQNPHIDATLRHLEEYASEGLRTLCLAMREIPEHEFQEWMKVYEKAQTTIGGNRADELDKAAEIIEHDFYLLGATAIEDRLQDGVPETIHTLQEAGIKVWVLTGDRQETAINIGMSCKLLSEDMMLLIVNEENAEATRDNLQKKLDAIRNQGDATIEMETLALVIDGKSLTYALEKDMEKLFLDLAIMCKAVICCRVSPLQKALVVKLVKKYQKESILLAIGDGANDVSMIQAAHIGVGISGMEGLQAARSADVSIAQFRYLRKLLLVHGAWSYHRVSKTILFSFYKNITLYLTQFWYTFQNVFSGEVIYESWTLSFYNVFFTVLPPLALGILDQFVSARLLDRYPQLYNLGQRNTFFKIRVFGEWIINAVYHSIILYVGGSLFWINDGPQGDGFPGGKWVWGTAMYGAVLLTVLGKAAMVTNNWTKYHVIAIPGSMAVWIVFVAVYGEVAPKLNISVEYFGVIPRLFTSPSFWIEMPTLAILCLLRDFAWKFSKRLWRPEAYHHVQEIQKYNIQDYRPRMEQFQKAIRKVRQVQRMRKQRGYAFSQADESQTRVLQAYDTTQHRGRYGEMASSRPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ40</accession>
    <name>A0AAE0MQ40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_472275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679354.1">
        <property type="nucleotide sequence ID" value="XM_062827139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ40"/>
    <dbReference type="GeneID" id="87864293"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="367" mass="40511" checksum="5D2D6076AA62E23D" modified="2024-05-29" version="1">MASISSRLSSQFVLLAHRTAPCARTPSQASATRFALVFGSGSGSGFRSAQTARFFASKAKKAAKKSASSSTVITTVTAPPTVIPASYAEQLAKKGRTLLYEAHSHAWFRFASFTTGSFCVTYSLYNYWNIHLNPPADLATWVPYAYGVICAMTIGMGGYFFMGMRRIIRHIEAVPASQIASQITSGGAASASTKKSKGWAELLTIKPKAVPVTTPTPIYIEVAYSRAIPFLPNKKEYYHPSEVEMPFRMQLLCERLNTLSAQKNVGKNLPTTKTGQIIAASKQKAAREKERKERMQHLLTLPFRDAAKVFRGAYEGLRRSFYREGFAKVYLRGVEYKLDMTSGWALDDGRAIDRLVHVKPSANINAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQG6</accession>
    <name>A0AAE0MQG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_431012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679774.1">
        <property type="nucleotide sequence ID" value="XM_062824921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQG6"/>
    <dbReference type="GeneID" id="87862075"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="401" mass="43279" checksum="11D96571966D9BFB" modified="2024-05-29" version="1">MPGDQENSAATASSSPAASSSTRVSETNTRISHDSFHLERPKTPGELEDGEDDHDQSLFLPEHENPISQPSENSPTSAFFWMAINTIATVLIVFTNKSIFSTPSLRLTQLSFATFHFLTTYLTLFLLSRPPLSLFVPRSISLRDTLPLSIAMSLNVILLNLSLAFSSVTFYQIARILLTPTVAVMNYVLYRSVLPGRAVLALVPACVGVGMVSYYDTLPLPSSSSSTGTGTGTGLAADQTQKQTVETTTPLGILFSFLGILASSLYTIWIAHYHRKLGGISSMQLLYNQAPVAAFMLLYAIPFVDVFPNWMVDVPVQKWVLILLSGLWASLINISQFFIVARTGPVSSTVVGHVKTCTIVALGWVVGGRAVTDRAVLGVVVALGGLLGKFRLPFAADEGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQT0</accession>
    <name>A0AAE0MQT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDP-alcohol phosphatidyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_429979</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679445.1">
        <property type="nucleotide sequence ID" value="XM_062824854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQT0"/>
    <dbReference type="GeneID" id="87862008"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000017">
        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3340503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="287" mass="31482" checksum="A8C62776FF341C29" modified="2024-05-29" version="1">MNNRLSVAPVHARHFSVSKSWRSQEDNKNGTKPPSRLAKTTAALKAALPQTGAITKRENIHTIPNWLTFSRLVAAPFIGYCILHDHHAWTLGLFAYAGVTDLLDGWIARRWNQGTVVGTIIDPMADKTLMTVLTVTLATKGLLPVWLAVIILGRDVALAISALYFRWISLPPPKTMARYWDFSLPSAEVRPTAISKYNTALQLGLMGLTTVAPVVPALDLAWSLMVMQYGVAVTTIWSGASYVYSKDAVKILTQPTTPKAAEKEEGNTEVVDEAEAKKVKDETATKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRM8</accession>
    <name>A0AAE0MRM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_426650</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681752.1">
        <property type="nucleotide sequence ID" value="XM_062824642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861796"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="125"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1960"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2244"/>
            <end position="2368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="482"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2189"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2387"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3345139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2471" mass="273300" checksum="26216E83E7DEFED0" modified="2024-05-29" version="1">MESVAIPPQDDQQQLDPPARIFERLRQIAGFAWDETKPPYHSTYDNWHVFGTRFVSPFSTTGTPAPASPAPYPNTSPSSLAKLAPGHRASPQDRPNVSASHSDAGSDRSVTSPPTVAHHATDAPVVEELVVARISYHVLREERAYHIAKSLVSTVDPNAEHIARPIDLIRLNPLPGDRGTIVVAIYAYSGENYLFKVLDMGPAFFYADKHNDRWEAQRKEHPVLEEPISLQHFLDFAIGAAQCLEMLHHSQSIVHGEIRPDAFHYNLELNRIKITSLGSGLRSFEHGLTSTGWSTLSKEVGARHKLQYISPEQTGRMPAEPDTRTDIYSLGVLFWSLLTQQPVFQGDTPLDIVQGVLGRRIPNVSQIRMDVPDVIGRIIQKCTSKNVSDRYFSASGLRHDLVKVQELLGSGDSQSLKDFQIGSRDVSSSFRLPTNMIGRDRERSELLKVIERVSKSHGMNHKGGVNWGSDGSVLSNDVVDSVEVSSEGASSAEGLNRQSGSWALPDPRNRVSLPPSALGTISVTTSGETTSSGTSTGTSTISGGNRQSRQWDKPAFETASLNENVSSDASRGSGLLSEPTSTISRQLGSKFRKQRQGNCEVVIIEGTGGLGKSYLVQSILADARRRGYCATAKFETARRTAFGPLLQLLSSLFRQVWGERNTETPFHQALKHHVRPVWPTLHKVLGLPEFLLGPPDNIPQRSNSTSSQGGGQPALKRRGSSPEFGCNNMYRHSSKVSSATQTSQEFLRAGGSTQTSRLTNTFLDVLRMFTHYKFICFCLDDLHFADDESQELISQIIGARMKMVMIITYRPEEIEPEKVLQILSPPKSEELPRGAGAPIMTKIKLTPLSEDDIIHFVSSTLCLPKEDVTPLALVIQSKTAGNPFYMREMLNAGYRKKCIWYDYLVGEWKYDLDKLFDQFQGEQNYDVLDTAFITRRLSELPPASRSILAWAALLGQTFSFDLICRLMTGEFHFEEDKDKGQQEEDCSYIIPADESVAGLEAAIQACIIVPSDRDDHFRFVHDRYIQAAAALQECNARKMHFAIAQTLLKYHANDRAYRDNAASHICECVDIICQQVSHRRSYRTLLSRCAQEAAVSGARPTAAKYYGNAVALLQPDPWNDDAGDSSYEETLQLYIQAAECYLYMGLHTAANDLLQTILAKARTAVDRAPAWVLQSRVFAQGGNSEQALDSLRLCLKALGVGFDDNPSFEKCDAQFERLSVRIQAMDRSELVNPSKTEDITLASLGAVLTETVSAGWWSNCLYFYQLALSMMELHLEKGSFPQSGLAFLYLGIIALTRFNLVQFTVQLAGIFLELLEKYRDPDSMARGYMIYANFVGHVQFPLGAIANQFEASVEYAAAVGDRISAILCFGLAAQLRFFASENISDVEAFCQYGCEEVPDWHLDTRGGAILIAIRQVCRALQGKTQVTDPYEVMSDEQHKVSTYKSWLTAKASVERTLMFYESIEIIPLFLYGHYERAIEIGEACYKNSKMIWSARNTKLAQWFYALSLAAVILREQQDPRRLAEDEEKFKSRVEETIEKIDELNKGLKDWQAVNNVNYLAWSKLLDAQISEIRGQYGDAIRQYEEALDHASEHNFLFEEALGNYLMASVFIRHKGRRSARSALRDSIALYRQLGATGIADLIETGHSILLHGPMRNPRTADAGVQTDFTGDAASVQYRAADEEGLEDEEETAQAAVAALKGERMTAWRGSMQPEAGVGLPALDMIDLHAILVSSQVISSVLRVDELLKTMCDVILQTCSGSATLAALVVYEDEKVKDGSPLCVAASGDPDKGAEAHIPGIPLSGTDLVAENVILYCSRFREVVFLRDLVSDERFGNVSESWLRRNPNSKAVIAIPILHGSENPLLGVLYLEGVPGSFTDRNVTVLQLLVNQIGISYSNALAMKAVEKVSAENVSMVALQKRALAKAVEAETKARNAEAEAIRNVKLAEEAAKAKSIFLANVSHELRTPLNGVIGNSELLRDSNLNREQLEMADSIRVSADLLLTVINDILDFSRMEADKMKLYIIAFNPEEMVREVVRAASYSNKEKTSKKNVKIVHDINLPPMLIYGDPIRLHQVLGNLIGNSLKFTEDGSITIGAKVDSETTEKATLTFWVKDTGIGISPQQLDKLFLPFSQADESTARKYGGSGLGLSICKSLIESTMKGKIRLESEENVGTTVRFTVTFDKAKPEVMAGDTQSTSPVQMEPPRDRQPRPLPGAVENGDVGSDQVPRPYIDLTHIPRNQLRICIAEDNSINAKIAMQYMHKLGYPNVDTYDNGLKAVEGLREKARQGNPYHIILMDVQMPVLDGYEATKMLRNDPIDAVRKILVIAMTASAIQGDREKCLAAGMNDYLAKPVRGELLKRKLDTYLGASASMSFSTQRFLERRFAQRPGSPQPINPGSSSPKKDVDTPLSSPVPPPLADNTAASASTVKIGVGSAAASLREVAANNRRKQQRQQEDFVGQAFVLSIFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRW4</accession>
    <name>A0AAE0MRW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_230239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680585.1">
        <property type="nucleotide sequence ID" value="XM_062822168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRW4"/>
    <dbReference type="GeneID" id="87859322"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3342792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="408" mass="43436" checksum="5C030F91411285DE" modified="2024-05-29" version="1">MTVDKNINQQKKTSSHIFYSKILFLFSLIVLILAIFSSRIISSFRVATISTQMMASSQYAKELEVAQLAVQRAARLTKRVFHEKAKGTVSKDDKSPVTIGDFGAQALIISALKANFPSDEIVAEEEAAQLREDTPLRDQIWELVKSTKLDDEAAEQLLGGAIKDADAMLEIIDQGNSQGGAKGRIWAIDPIDGTKGFLRGGQYAVCLALMVDGDVKVGVLGCPNLPVDDAAPLTADIGTNATDEGRGVIFSAVQGQGATSRPLGTAGLAEGKPIAMKPITEMSNASFCESVEAGHSDQGVAGQIAQKLGITKPSVRMDSQAKYGSIARGAGDIYLRLPVSKSYQEKIWDHAAGDLIVREAGGQVTDVNGNRLDFSVGRTLAKNKGVIAAPATVHDQVIKVVQEVLGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRY2</accession>
    <name>A0AAE0MRY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_231866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680645.1">
        <property type="nucleotide sequence ID" value="XM_062822197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRY2"/>
    <dbReference type="GeneID" id="87859351"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.250:FF:000006">
        <property type="entry name" value="Malonyl CoA-acyl carrier protein transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="64"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3342852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="438" mass="48647" checksum="951C4C6C36EE47FC" modified="2024-05-29" version="1">MPLRGPLRRPALALPPSALLSSNNAITKTPLRISPLPRSVVVRQRRGHATHLPVPDTRPKTAIFFPGQGVQRVGMLTPWLEAFPSTTSEIIDEIDSVVGYKLSDVIQNGPGKDLNLSPNAQPAIMATSIMIIRILEKHFNFRVEDNAHFTLGHSLGEFAALVAGGYIHFQDSLRMVHKRAEAFSNATRQAEEMYGGEYGMVALVSSKAEHLPPLCAAIREFVGYDSAGPKVESADDWSPIDQVLIANVNSKTQIVLSGSIERIKTLVAHVRQFLGHDPRAVRLKSDSPFHSPIMKPAVGVLQQMMAGNSMVKGRENEDIVTFPGKVTCISNVTARPFESREQLKDLLARQAVETVQWWDSIKYLDQSMKVRRWVGIGPGYVGRNLVGKEVGMRGKDVIKGAGVWAITDPKEIEEVLRGLEETDFYEDDEWQDAWDRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS61</accession>
    <name>A0AAE0MS61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_539947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682368.1">
        <property type="nucleotide sequence ID" value="XM_062829133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87866287"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="1147"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1251"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1321"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1326"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1341"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3345755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1416" mass="153146" checksum="7926821E556F88BA" modified="2024-05-29" version="1">MGFARACAGGTRWAQEPSDQHFYTTGHEPTADRRAITRDNQPEQFAVLRPTEKKVIGIDFQVRANRHLSRSHLRNRKRASYNHMRRPDSHLSKLKSLPGVLDKGCRPLDLRRGGVWGMTTTSRDAYTPLESLFLLRGIAKHGLDQQAFHRIADVLQQNRLIKTAPSYDAARLRPEPLQELFLHLLWDELKQEHDTPGPKPDGGLSPNSKRRRLQPPPLPTLREAHQYVPKIESLYRKLEQTYVNQTLQEIDQYERHYDRVQTEVRVLEQAVARDEEQERRQKIPDGVPAQDGPVAHKPSPALGPVPSPVAVQGPGARLPNGAGHGPSPVASPRIASPRLPPPQTQSPRTPSTPQLPIPTPPPPPPPPPQQQQQQQQQQQQQQQPPIPPQLPPQVSAHIPPRPEVVRHASVPSPTTQLPPVRSSPASLPPTTLPATLPPTTTAALQPQLVSSPRLGHHNIPRGPITSGPGSPRPMTAGGIPHVLQPPVSFSQAPPQPPQPPKPSTPTGGLPRLDGVTGPSRQSPVLPTAHHPATTLPQPQPPIPGQAQGGQLKWEPPYQPQAGHRPILGPGQQHPHYSPIPQSPQPLHSPRLPSHLPPQQIQQHPVVSRPPQPPPMKPQVLIPPQTGQHYAPPLQPAPIRSMSDSPGPSPVRQPLASTAATGIPRATFQQHPSPYPPYHLPQHLQQGAAVSSPPQSPSAIPPRLTHGLAAPQQQQSPPPLQPQQQQSPQHQPQALQAPPPFSQPVTTSMAPSPSLAPIQSEVQRAYPSPYPPQLPQASHPPQAHPPQVSHPHQPQAHPPQAHPPQAPQVPQVPQVSQAPQPHVPRAPQVHPTPHLPHPPQAALPQVTQAQSPRIPPITHAPQPPVTHAPHVPHPPQQQQQQPQPPIQQHRPRSHSAATTHSGPRFSPIASVTQTTLVPPAKLGLGSGTKWVSAASASTPKLPDVRSGGDEIRPPAFEPLSPVQQPAVLPTARQEPARPSPARQPTNEASRPRGSVPLVGPQPTPASQARQQAAQKVSRPVDKPAAPEQPSTAKEIAKESVKEPEPATSVKNEVDTPQATMDTGDTTADESGAGKRQAARQAKRKRDELSPTPAATPAEATPNGNATPANEKSEPEAPATASAAPPDTNRVLWSRGFHKVSASAMEQIVRHRSANMFAAPIREKDAPGYHKVILQPQDLKSIRAAIAQGNRSATQAAAALPGGDPGHMLVHLPQMEELVPPRGIINTAQLDRELAHMFSNAIMYNPDRWHGPGSSFLAEREERTDDNNQAGGHGHGHPGDVLGYKVDEFGVVKDARAMFSEADSLLADLRVAEDGRIKTMMEDGTLQMPGNGSQNHSRQTSKGGEKAEEQKEKEKPSGDGDKEKDKDGDVSMVGDKEGEAPGDGKLFISTTSTAYDYLYRISRRPGLKNSHGSLDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS96</accession>
    <name>A0AAE0MS96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMC oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_148339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682488.1">
        <property type="nucleotide sequence ID" value="XM_062821037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS96"/>
    <dbReference type="GeneID" id="87858191"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042011839" description="GMC oxidoreductase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="5">
        <location>
            <begin position="454"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3347406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="67002" checksum="1F8EDB4529136D09" modified="2024-05-29" version="1">MRFSFLSLLLAPALAAAADPTTTYDYIVVGSGPGGGPLSAELARAGYSTLLIEAGTDQWDNPTYADIQNFNEAANDETTRWDFWVKHSDDAARDLKFKHTTWDTGDGTFYVGLDPPEGAKLLGIQYPRAAVLGGCAMHNAGVASLPEDDDWNRIVNLTGDASWEAGKMREYLKRIERNEYAGVDDATHGHDGWLAISNTDPSWAKNDSNPAVKIMKRLAQLTGQDPSQVADLANTDLLGDFPNRDTMSSFFNMATHSDKNGKRASPNNYIRATLADPAKYPLTVKLNTLATKVLFNTTTGSKPRAIGIEVMEGSSLYRADPKHIPGTTAPKVHRYFANREVILSGGVFNTPQLLKLSGIGPATELQKFNISVVVDSPGVGEGLTDNYEGSVLGLGKVPIESGLITILFRTPNAPTAKRNIYAWCGAFSFEGFWPGYPTYYGAEQFSCAMVHVKPRSQDGSVRLTSADPQDKPEINFRFFEHGGDEDLSELVSAANILRESWQAAGEEVLPFNELHPCPSSESNSTCSEAQQAEFFKTQAYSHHATSSCQIGAEGDEMAVLDSKFRVRGTEGLRVVDASAFPNVPGFFPSVPTMMISVKAAGDVLAAAREAEADADAGVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSM6</accession>
    <name>A0AAE0MSM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carbohydrate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_461079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682757.1">
        <property type="nucleotide sequence ID" value="XM_062826583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSM6"/>
    <dbReference type="GeneID" id="87863737"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000026">
        <property type="entry name" value="Myo-inositol-1(Or 4)-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="556" mass="59552" checksum="E27775B708FDEC2C" modified="2024-05-29" version="1">MPTMACFTNKGRSVCFGMGVLGYRNRPTIITPRYLNTTINTPNNTPPRPGATTKTPPAADDHHLDDVDTPHTHTLFQRHHRYKCPLPLQCGSTHRHLNLNLNLRDTSSPQKTKKMTVTTSDPSKPPYQHERHIAELAVQRASLLTRRVLAGILNPSASSSSTSTSGTSTPNPHLDHDRRISVASISKPDFSPVTAADFAVQALLTAAIRAHFPHDGFIGEEDADALRADPVLARQVFELVRSCDASTESGDEALLSLAVLPQTIPEMLSLIDLGGRGTGSPTARFWAMDPIDGTAAFMRGQQYAVSLCLIEGGREVVGVLGCPNLGITLPFNSSSSASSSASPKAKNTCTATYIISEDSTPSPSPDAQGQDQDQQQTTNGILLSAVRSQGATIRPIADQTSQADLLPATPLTKSSTASTSPTDMSNLHFIDSLTTPATSSSLVARVATLAGVPNYSFPGTELYSSHMRYVAMILGGRSHVQVRIPKPMTKQTYIWDHAGAQLIYVEATGGKGKVTDLWGRQIDYGRGRVLDGNWGVVTADEEVSGRLLEIVGTLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSP5</accession>
    <name>A0AAE0MSP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_557897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681455.1">
        <property type="nucleotide sequence ID" value="XM_062830090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSP5"/>
    <dbReference type="GeneID" id="87867244"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3344842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="444" mass="46046" checksum="4D6F4C2BC87DBE5B" modified="2024-05-29" version="1">MSRPSRPGFLQPARSAPAPASVTNTNVTAAMVSVPGDIDIDGPDYHHDTEHRRGPGPGPGSVTAAPSTTGSTTTTTTTTTGRASSSGFPLPFFAGSSSSKRSTAPTVSSVSTAPQPLIPVPNAYTGQAVPVPPLAGTATTGSSTSGASTTAPAFPPASRSQSQTSRPGVQQPPHTPHTPHTPTVPGPNPGPLPTAQARTAVLASISNLLDRELTGRASLLHQNHNAILKQEREMSKAVEAFKKENDKLEKLAREGTKRLKEVGDVQNWAEVLERGFLRVEETIRRANGDFYRDYSEGSGSYSGSWSGSGSLWSGSEVGVGVGVGEGEGEGDDGKDSEGVGDGESKVKNGKEVGGSGSKSVEGEGAAEVENLNDDKREEKDVERDAEGDVVMTTEDDVQERHTRLDKGKGKAVDDTIPEPSMVPLPQSPGFGGGIQFPNLTPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT53</accession>
    <name>A0AAE0MT53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_149968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682564.1">
        <property type="nucleotide sequence ID" value="XM_062821066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT53"/>
    <dbReference type="GeneID" id="87858220"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="373"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="664" mass="73198" checksum="91B6AA67CA5748FB" modified="2024-05-29" version="1">MTRRLPPPSTPAQLLRLRLTRSALSTTSPLATCPSSRTASTKARAAAITPSPRIQSLLLPPSTATTPTATTTTAFFSRNNLSTTTTVNKRDQTTTTTTLAPSTPVVLRASVTGLGLLFVLGLGLGYGITDFLGQKSTEQQELGYTTIEKNIQDILDDQSSTTNMSGEIAPGRPGNLTPEQEEKLKQLWKLIFQVCGVYSPSESSTPAPEAAAAAATTTSDAASIKGDDKKKKSKLSMFSRKHKKDSDETTTTSDSASTASGSTTPASPAIVLNASTTSGDDDKYNQLSKFHETLASQSPAAIRETIWSMVKHDHPDALVLRFLRARKWDVEKALVMLISTMNWRDNEMKVDTDIMRSGEGGAVEAEKMEAKTSEEVARKKLAIDFLTQTRMGKSYVHGVDKQGRPICYVRVRLHRQGEQSEESLERYTVYLIETCRVLLQGGVDTATIVFDMTGFSMANMDYTPVKFMVKCFEANYPECLGAVLVHKAPWIFQGIWRVIRGWLDPVVANKVHFTNNIAEMSEFISPEKIPKDLDGQESWEYKYVEPIPGENDKMKDAETLDKLQAARAELVREYEEATLQWIQSGNNSEELKKKRDEVAEKLRVDYWNLDPYVRARSFYDRVGVLLPGGKLDPYLEGKKDGGVSGITEGVAKVGVSETQADDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTD1</accession>
    <name>A0AAE0MTD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_153894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682804.1">
        <property type="nucleotide sequence ID" value="XM_062821120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTD1"/>
    <dbReference type="GeneID" id="87858274"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="91"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="322" mass="35217" checksum="4F2A4DC124EF2E3C" modified="2024-05-29" version="1">MADNKFDPEYFQTIRPLIALKESLPPPVPTTDIDSLRANSASFELVLAAIPDSPDITETTYQIPSKDGTLITLYRFTPAAAAATPGPRAAVLHHHGGGFIQNTVDQFRKDIKRYAHGSGLTFYAADYRVAPEHPFPAPFDDCYAALEWLHANAASEQIDPARIALFGISAGAGIAAAVALKARDDKVSPPIKKLVLAYPMLDDRTYWPEEHPLNPYLMWTGAFNRIAWGAYAGADGVKEISPYAAPARAKDLSGLPPTYIDCGELDLFRDEDVEFGARLLKAGVSVELHLYPGVPHAFEMVAVDIRVSKLAFENRVRALENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU70</accession>
    <name>A0AAE0MU70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_571344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683000.1">
        <property type="nucleotide sequence ID" value="XM_062830479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU70"/>
    <dbReference type="GeneID" id="87867633"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="483" mass="55633" checksum="86AF4BC5963F2720" modified="2024-05-29" version="1">MAEYEVDDLLSHSLCTTKPIEQESFADQDLRNHLESVHGTSWAGETKLQDQWRNGYITTPDQFLEPWDGRDDGAYKNATYEVYEIPGSGDQKCIPEAKHKENGEDSQQTLSVKSVWNTLKEVNKNGEVVGRITILQEVPPLVLGAVHMTMQKHFDMDELFQHLISNEGNSGKTKAYMDRTTESNPLRQRTFFFVFKYYTVVNKNKCTPAPWQRYDTRPADRKWPDHVDIAECSSILALSLGGDPIKKYRARVKKRDIKDHVIFDTSAPWQLLSIQCFPDDEHTMRSKGSNRPLCNGPFAFLDSLALEYHDAVTRYSQINDEVTKLITPPSEFMFNSQLRDGLLFEDENFSYSRRYFWAYNTLGVINVGIDSMVSAYKETFTQEFWDGKHEKLWAHPNPDLDDGKAYAKCMGVLRQELDREVNNLEKVRKKNEKTREEISSLREQLFSGSSVKESRRAIEQGDNIKILTVVSMLFLPLTFVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUP8</accession>
    <name>A0AAE0MUP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_131174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684992.1">
        <property type="nucleotide sequence ID" value="XM_062820806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUP8"/>
    <dbReference type="GeneID" id="87857960"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3351697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="362" mass="40258" checksum="C1D70962160A0120" modified="2024-05-29" version="1">MWRDRTNLYISYRQSYAHHPTQRNRYAPQSAGDRFGGSSGGAGGSTGVLFSADDDRRGLLSAGAYDVDDGDAVIEMDLLPPRWADSSDEVSELLADIARKSQKLERLHQKHVLPGFDDEEAKKDEEREIEQLTQSITKGFHDCHRVIQRIEQMVREGKHNGQMSRADEVMAKNIQINLATRVQEASANFRKKQSAYLKKLRGMSGLASPTLDRVSTPLSSMGPSGLPPGNSSNSASILESDADRVFSQSTLQASTHQKLLHSNDQAISQREREIDEIAQGIIDLSDLFRDLQTMVIDQGTMLDRIDYNVERMATDVKEAAKELTVASGYQKKTTKRKIILLLLILIAGMIILLVIKPKKHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUU0</accession>
    <name>A0AAE0MUU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_456922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684409.1">
        <property type="nucleotide sequence ID" value="XM_062826327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUU0"/>
    <dbReference type="GeneID" id="87863481"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="465" mass="46208" checksum="1E8735752282C7F0" modified="2024-05-29" version="1">MPTATTVKQPSAAVSSTPKVKKTTTDAPKAVKEVKHRSSSTKPKSTPLAETTDNVVKKKPKSTPLAEDKVATIDHAVEKPTTKKPSTSGHTHAHTSTTKTSSHHKPHAHESSASKHESTSSHRPGRRHHAHHHHNPDGSLTRHGERARATSSSIAKPLAPAKPFAPALDADGNPKPNIRPATMTAHIKRAVRKSEAMNPSKPTKVEPETALPKVNVPTPQTARQKTAAAADAEATKRAKKVAAAAQEEQAQWDQQQQQEAQKPKKEKKYAPEAMIPTSRFVGNVGKTAGAALDTTGEVAKGVTNTVGRTAEGALGGGVGKTVGAAAGGVGDTLGAATGGLGRTVEGATDGLAKGGPLGAVGGLSKGLGQTVGGVGKGLGDTVGGTVGGLGDTVGGPLGGVVGGLGRGVGGAVTGITGGLGDGVGKIGQGDLLGGVGDVVGGVTNGVGGLLGGVLGGLGGGGGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUY0</accession>
    <name>A0AAE0MUY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1761-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_459675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685292.1">
        <property type="nucleotide sequence ID" value="XM_062826476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUY0"/>
    <dbReference type="GeneID" id="87863630"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18141" checksum="5982E2B07975DA4D" modified="2024-05-29" version="1">MSLHYLPPVKPSAIALGTIFNHTTELAIMTPLFGQTYQRAKLSNSKEEFIKSREATSAVMAWGSSLVGSALQSYGIGALINATGTLSYRGAAYLGGLIFAATSAPGFISELFVEKRAFETVGINVLAKLFETVGLSVFLTWWGTRTNPFEYSSATSGSPSLGRTSWRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV22</accession>
    <name>A0AAE0MV22_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_547093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685412.1">
        <property type="nucleotide sequence ID" value="XM_062829487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV22"/>
    <dbReference type="GeneID" id="87866641"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3352117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="106" mass="11768" checksum="BC794759EA7D2C37" modified="2024-05-29" version="1">MSATNTTTTTTPTPNAIPIKTIIPSHYKTLNLPPTCSGKKYDITLAKEGDREMGEKLGRELKTKGEKAVVRNVNLKGEEVHEGWGEERVVKWTVRPRGPRVRGTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVA5</accession>
    <name>A0AAE0MVA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_126706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684889.1">
        <property type="nucleotide sequence ID" value="XM_062820750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVA5"/>
    <dbReference type="GeneID" id="87857904"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="141"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="599" mass="67242" checksum="E7F7499CFEBD6FAD" modified="2024-05-29" version="1">MTVDFTARPEKPLPYSDDFSSADEYVDSLLDFATNSHLFQFLCGGVHILDFFTSEPGLFVSAVPKEWQDYLVQTEPMVLLDFLMRDDLDALATQTGPGQPPETLVQYVKDIRKLSLRRSFQPSKPKLPVLPRQVALGMNTKKVHEVTHFSGYIDRLSEDVARARGKELTHLVDFGSGQNYLGRALASPPYNRHIVAVESKEANTAGAKDLDILSGLAEREKRIRNKKLYHRIMESVDPSEANDEEALKRAAKALGVADEDIATIDLRSRKELQATYAREEGKGSIEYVVAKLGDADLAPVISQLEYTETHSEDDLSMMAVSIHSCGNLSHYGIRSMVLNSSIHAVAIVGCCYNLLTEKLGPPTFKPCFSRPTLQPLNARVVRESERRDPQGFPMSEKVSTYNDQGIRLNITARMMACQAPGNWTDKESDAFFTRHFYRAVLQRIFLDKGVISKVYHGPSEGEGEEGNESPFNFSTNPVVIGSLRKQCYTSFSAYVRGAITKLTTNTDFSQYSQIVREKLSDITDEEIAKYEAAYLPRKRELSAIWSLMAFSACVVESLIVTDRYLFLKEQSDIVRDCWVETVFDYGQSPRNLVVVGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVC0</accession>
    <name>A0AAE0MVC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S24/S26A/S26B/S26C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_410671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684919.1">
        <property type="nucleotide sequence ID" value="XM_062823833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVC0"/>
    <dbReference type="GeneID" id="87860987"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000015">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042118777" evidence="8">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="146" mass="15938" checksum="233190B8B930D94E" modified="2024-05-29" version="1" fragment="single">FRVLFSTFKLLAFTHLFLEHVLSMAPASGPSMLPTFEVVGEWLVVSRFHKYGNGVNVGDLVVYQIPISTSGELGVKRIMGMPGDYVLVDTPVPGGGTVPEGHCWVVGDNLTASRDSRTFGPVPLALIRGKVFAKIQSNWLPKLIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVD0</accession>
    <name>A0AAE0MVD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF2264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_129982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684964.1">
        <property type="nucleotide sequence ID" value="XM_062820789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVD0"/>
    <dbReference type="GeneID" id="87857943"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="38"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="3">
        <location>
            <begin position="395"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="76380" checksum="088C1727111C47A1" modified="2024-05-29" version="1">MSSTNKPTTTNTTTPEGVPGLLLGHSTPHPFSLIPLSSRSSVQRLLTTLLDPLLPFFSPLKSRIRIPGATAVRFDQTASEIEGLARPLWGLACLLAGGGEYEYKDWWIEGIRNGVQEEEGGEEFWGWPRDNDQRMVEMCPLGFALAVVPGLWEGLGERGQRGVERWLGERVNEKNMPNTNWLWFRVFANLGLKKNGGKFSQERLDADIEHLNTFYRGDGWSNDGPEGIHQMDYYSSSFAIHFLQLLYAKLAGEDEPERAAEFKKRAQIAALDLVHYYDKEGRAIPFGRSVGYRFAMVSFWGALAYADVELPAPLTWGMVKGIVLRHLRWWQTQDNIFSPAGTLTIGYSYPNMYMAENYNSPGSPYWACLAFICLAVPETHPFWTSSEEDPWPLIPAIKPLPQPGHIMSNLGGHCMLLSSGQACSYPMKGTHAKYGAFAYSSAFGYSVPPGCFTLEQYALASQLGFSDDGGEYWKTRRLSTSRLVTKENNPVLVSDWTPYPDVFVTTYLLPPTEAAPNWHLRAHHIRAEGGREVMTADGSFAILNERTPDGRYLDLYDPEKCEGTFPKLIGNYDLNTPEAWAPAKQGAFAVSRAGAVGIRALEIEKEGREAMLVNADPNSNLVESRTTIPTLQHRIKKGERWWYVTGIYAKPAGEGVAKESYLDGWERGPEVPGWLREVIEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVH7</accession>
    <name>A0AAE0MVH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_13233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685833.1">
        <property type="nucleotide sequence ID" value="XM_062820823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVH7"/>
    <dbReference type="GeneID" id="87857977"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="217" mass="24625" checksum="143C653481CE1924" modified="2024-05-29" version="1">MEWEISVFKRLIKEQVGLVVAAAAVPEAEDTPLPPMLWSSMGGEDQKFWYDLLSRAAWANRKDAVRFYVEELGVPSFSFPFPKLPREDTRESWAAMDEEAREEEAEDYAYYNVIQSPLESTFGRGSVKAAEYLLNTGLAGEGELPWEGLEEMGKMWDISRIEGRKERVDEILQLLRAQYLVRPGTFDVGITAEVRSQQRCWLSGCPSLVTVLSGSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVX3</accession>
    <name>A0AAE0MVX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_504884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686268.1">
        <property type="nucleotide sequence ID" value="XM_062827953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVX3"/>
    <dbReference type="GeneID" id="87865107"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="148" mass="16835" checksum="04D2355573408D47" modified="2024-05-29" version="1">MSRIFGRRSTSLKLMSPPDSMPLSEQENRDSSDNHHDSAYSSLLDPMVRAMEPPEHRRTKSTPGAWMQGFATSGQDVSHRTWLSTAERRPSWTGERPPPRKLVKDPNGSGRPSFSVELSDSDGEKEKGVLRRQLTRLRSFYRREKPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW88</accession>
    <name>A0AAE0MW88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_504620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685939.1">
        <property type="nucleotide sequence ID" value="XM_062827931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW88"/>
    <dbReference type="GeneID" id="87865085"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="605" mass="61022" checksum="9FBB659F1A671D9F" modified="2024-05-29" version="1">MTPGPVGSAVVPVPGMEPLVGNGADERENALDNGLEIPVPVTDVGDPVPVIGYGDVAFGRGNAPEVDASLIGLVPVPVGPGKPDVEFVKGNGAFEASELLVEGGPLEAPVPRGALLLGRGLIGKSVLVNGIPPVAEGPVALGSVVVEFGKGYGPDELLGANELRGKAEVPVPGAVEPPVGPASEVGALLITDGPVPRGAVLAPDPGTGVVLGRLDPYPVVELRGADAVKLPKGAELDISGAEPEETAPDGRVPVSVAGTVLFVSGKGTDGEPGVEVGSAEPIGPPVPVDPGTNGVPVPKPAPVELGIIPDELDTGNGAERDDSWEVTDPVVLDPVGPVRGIDEFVTGKDAKEDPDGKMLPDTGGVKPVVGALVGLEPVPGNVVPMYELNDIGTEALVPEGGVNVPDGGKPELEFDAGNGGELEPEGKVLLLEGPVAVLLAEIGRGADVPDKLDEKLGRLEPPDAGKDVAADVGTLEPVGPKLGPGLEELVNGKGSAVASDVELLDSLLGGTVAAPVLEFERDELSGPTLMLMEITGLGEVDDVVLPDVGFAVSEAELADVVDTVDVVLRKDVDASVVVVEFNVGDAETLPEIDRDEPDDNGAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWE0</accession>
    <name>A0AAE0MWE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_451920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
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    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
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    <dbReference type="PANTHER" id="PTHR22904:SF523">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="4"/>
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="72"/>
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        <location>
            <begin position="137"/>
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    </feature>
    <feature type="repeat" description="TPR" evidence="6">
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            <begin position="251"/>
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    </feature>
    <feature type="repeat" description="TPR" evidence="6">
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            <begin position="325"/>
            <end position="358"/>
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        <location>
            <begin position="525"/>
            <end position="564"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="EMBL" id="KAK3355414.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MWI6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686853.1">
        <property type="nucleotide sequence ID" value="XM_062827679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWI6"/>
    <dbReference type="GeneID" id="87864833"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="81"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="17120" checksum="355332A1C46498B7" modified="2024-05-29" version="1">MATNPNEPGAPLYSQAVSQDAGEPVTAEQIEKAPKTLASLEKEKSTEKKDTQQTESKKGTSDDSSEQKEKSPGLLSSATSTVTGAVGSVASGVTNTVGNTTSSVANTVGGVVGAASRGLGETITSVTGGLGKPVGETIANVGTSFEGAVRGKSEEKDEKETSDKKKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX12</accession>
    <name>A0AAE0MX12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_544683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686809.1">
        <property type="nucleotide sequence ID" value="XM_062829312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX12"/>
    <dbReference type="GeneID" id="87866466"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="534" mass="58696" checksum="8AE9C5C3FB08B540" modified="2024-05-29" version="1">MVLHSLHDLDPAEGTVRLRLADNSPVVLVPKPSENDPNDPLLWSRRKKRVVFLSVCSFAFLTNFGIGGLTPAFYILSQEFGKTTTETGALLLWPILTLGAFNFFWVPIANYYGKRPVFVFACGLLCACSMWGALADTFESLLWSLIVAAFAGSSTEALGASIANDLYFLHERGSVMGIYMNFISGGNTIGPLICGFIVSKYSWRWHKWTAFILIMINFLTVMFLVPETTYVRYSQKPVDSDSGTSRGPTPGPVGPSDAEKGIGSGNAQGARSPLGHTDESPAGLNLPKKSWAEEISVWPVVSRETPLWRLFFRPFPMWSYPCVIFAFLAYAISLEMTVAVNILNPFVFQSPPYNWSPMVNGLINIPGLIGNLFGSVLGGWAVDRFCDWKTKRNNGVYEPENRLWLCIVPLIISGSGCLVFGYGVEKTMGWVSLFFGYGMISVAMTAVPTIIMAYVSDCLLPVNSDALMLVNGSKNVVCFFFAASVLVWVQKVGYVEAFGTTAGVFALIMGGGMALLIPFGARIRHRQANWRIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX21</accession>
    <name>A0AAE0MX21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_66676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687437.1">
        <property type="nucleotide sequence ID" value="XM_062831250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX21"/>
    <dbReference type="GeneID" id="87868404"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF2">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042133379" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3356060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="232" mass="24191" checksum="389A932E8586AA3C" modified="2024-05-29" version="1">MVSATLLFAAAIAPLASAHFALEYPAWRADTLESGTNYSQWQYPCAGVPASTSTSGNRTDWPLKGGSLKVDLHHPWEYVFVNLGLGSNVTNFNYTLTGPTFWNVTGAGTLCVDLPLPEGLNPSDGQEGSIQVVTVGESGSALYNCADITFRANATALSKDECKTDEKVSFVQIKEQSDNSTDGGNSTDGGNSTDGGDSADDKKSGASFVGLNTVALTAVVGMALSFVTGMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX27</accession>
    <name>A0AAE0MX27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_415812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687452.1">
        <property type="nucleotide sequence ID" value="XM_062824005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX27"/>
    <dbReference type="GeneID" id="87861159"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="710" mass="79333" checksum="34E767424EE527AB" modified="2024-05-29" version="1">MSFPLFSLGFAPLSLTFPSSNVVKAIAIASLAALSVKMLLNTVAPSQAGHDHKHHRIDDKVCQESLATSTDDVNANNLTQSAQGAKQSRRIESATPMDHTITTSINNDKASHTTELIVAPKDVDLTKDVEIADDNTVIQGADSTEIGTDTKKACPAELNNAPEIVTSTHATPIVNDEKPAINSSNGVRSYRHSFPAVNIIEVVEVPSKQATTRSYYHSFPAVDIIEVVEAPSKQATVIASPIQSNNNTAALVNEQESTVSSDAAPKAEEAILNHTRKDSTALVTPKQSLFYSSEILIHHRTNFSTESQQTANSDLSATTPDTQDTLYSVPNIDFIDQLTPSGAKASEEDENHEENALTATAAANTTSRDNTRSKWYDFSHLSVEEMANLDTIIIIERPDTGISYTQLTCGFCYRLDEEENPLMMSQSEYEDLLAWFDSFKTKEEEIKLPLPVVLVTDEEGNERLAEEDNETSFESQVLDLQDRPACGVKYVLLTNGHWHYLNEDTTTARLMSEDEYEEFVFWLQEKQAEEDERLEQEEDKLGQEIKGIELFSYDDKFTDANHLNNAHDLSELEQSQEAECIGTSFNIVGLIDHPDGDKQYAIGNDDAVYWLIGAMFCLLDEDELDQFNRWRDGDKTALYGPIKQLKRPEGKEPKWKAPDLDAIFEEDEEEAEMAAEAAEEYIPKKWNKWGLYTIEEEGGEDQEDYADLWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZU8</accession>
    <name>A0AAE0IZU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_481948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000014">
        <property type="protein sequence ID" value="KAK3334274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676440.1">
        <property type="nucleotide sequence ID" value="XM_062827650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZU8"/>
    <dbReference type="GeneID" id="87864804"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="169"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="625" mass="67808" checksum="BD55D42D6A0685A8" modified="2024-05-29" version="1">MASKQAPHERRKGEAALGDFAEYAAQSQSATTNAPEVEHHAELDDILDSLNLSEPGPRIRLRDLLLSAADDDASLQKLVDIVGERLDEGHGESVFDIGFENHGESMKLTKEDWEVAYKRLSQAAAKIDADCQLLLTKNLGGDLDGTPTRDGDVSGKVMIRRRPSAAEEVIETRIAVVGNVDAGKSSMLGVLVKGDLDDGRGRARVNLFRHKHEIETGRTSSVGMEIMGFDSHGQTVLSDTPGRKLSWEEIGKRSAKVITFTDLAGHERYLRTTVFGLLSSSPNYCLLMVAANNGLIGMSKEHLGIALALNVPIMVVITKIDICPPNILEQTITQITRILKSPGARKIPIFIKSREECINTATQFVSQRICPIFQVSNVTGENLDLVRSFLNILPHHGRYDADAPFEFHVNDTFSVPHVGTVVSGIVKSGVIHAGDEVHLGPDGLGKFTTTAIRSIERKRIGVPAASAGQSASFALKRVKRKDVRKGMVVLSKTESGPPKVYREFIAEVLILSHATTIKTKYQAMLHVGPVSQTCAIIDVDRPFIRTGDRATVAFRFVQRPEYLVPGDRLLFREGRTKGLGIVKSLGYDPERPLGGVNVGEGGDKVAAGVEDAKNEGAGNEVKVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0M7</accession>
    <name>A0AAE0J0M7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_561399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676958.1">
        <property type="nucleotide sequence ID" value="XM_062830170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0M7"/>
    <dbReference type="GeneID" id="87867324"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32729" checksum="A03B47D4C3244734" modified="2024-05-29" version="1">MTDKGQFESGHRIPVSHQSFPGKETEMPNPQPLWDEIPTADGKSQKYRAAGKLKGKKAIITGGDSGIGRASAILFAMEGADSLIAYLPEEEEDAQETKRRVEAYGQKCYLVSTDLRDRENCKKLVDEAVKIFNGQIDILFNNAAYQMVVDDIKDLSEDQWINTFNTNIHPYFYLAKYSLPHMKRGSTIINNASINAYVGRPDLLDYTSTKGAIVAFTRGLSNQQAPNGIRVNAVAPGPVVTPLIPSTMKDENQKQFGSTPLGRPAQPSEVATAVVFLASEDSSAFSGQTLHPNMGTVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0W4</accession>
    <name>A0AAE0J0W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_480206</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677037.1">
        <property type="nucleotide sequence ID" value="XM_062827565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0W4"/>
    <dbReference type="GeneID" id="87864719"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3334871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="583" mass="66445" checksum="91542B3836BC9DD3" modified="2024-05-29" version="1">MALTALLPDLTTSSSLTQTLLTTLLLPLLTLYTIYIAIYRLYLSPLASIPGPRLAALTQWYEFYYDVILHGQYTFKIIELHKQYGPIIRINPWEVHIADPDFHRELLPTNTNRRRHRTPFFTKQFGADESIVSTNDHDLHKLRRSAVGPFFSMQNMRALQPVIEERVDALLARLREHGKTKKETPLDMMYPYSAMTYDIISEYSFAKSEHAVEDPDFRAEITNGILTGSNYGKVFQHFPFLVPYLASIPPQMLAAISPFYRTFLHLRACITVQIGEIEKSLRSEEGKNAHLDIPHPTIFHSFVNTEALPPVEKSVPRIAHEGHVIVQGGTVTTSWALTISTFHLLNQHTTVLAKLRNELREAIPDVNESVELARLEQLPYLRAVIKESMRLSIGASGRITRVAPDETLRFKPSKLCLQCYPDMKTTTDKEREWLLPPGTEMSMTSYQITTNPEIFPDPHAFVPERWLGKENEMGRLEKYLTVFGHGARVCLGMQLAHAEMYLMLSKLWRVWEGGPQVGGVGGDGKEEGEEEDSKEKGRRDGQTVGRLRLAEGVTVRDVEMAEDWFIPVPYRGSKGVRVYFESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1A2</accession>
    <name>A0AAE0J1A2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_553659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676477.1">
        <property type="nucleotide sequence ID" value="XM_062829984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1A2"/>
    <dbReference type="GeneID" id="87867138"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="83"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="358" mass="38580" checksum="F0B863AB9C197537" modified="2024-05-29" version="1">MAHTTPGISLSATSQMPQGKPHSINEYTSVKKPPHLDRLTSATHQESAVESVTIDVDDGPDGFVPGFLHMPPNFTAPDPFQEHHRTAAILLSGAGGGVTGPSSIYLSLACKLATLSSGIPTLRLDYRYPARNKHCVADVYAGMKYLQDLYGLDRFVLVGWSFGGAPVFAVAGADQRVIGCATVASQTVEADGIRKLAPRPVLLLHGTGDRTLSHACSERLYAMYGDKGERQLELFDGDNHALMGNAGTAEGMLCEFIARCAGVEVDEGLRREVVETELMNDGEREELMQRGGDLRGAERSHSHDKPSETTTATPSSHPGRSRTPRGTWIAGAAITPSATDHHRPPPDHRALWERGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1A4</accession>
    <name>A0AAE0J1A4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_446716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677205.1">
        <property type="nucleotide sequence ID" value="XM_062825812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1A4"/>
    <dbReference type="GeneID" id="87862966"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3335039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="136" mass="14302" checksum="B92C42B31609BA5B" modified="2024-05-29" version="1">MFLLMTPSVLLTMSSFSMGLISSTSTAPILSITSILSIVVSASSASLAVAASASPAPSLLSLSITAAATTAELLCLARGICALEGYSLWSKLPEGRLQVDVEKVFKCSDVGNKRCLHKDREMMAKTELYTPPEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1H6</accession>
    <name>A0AAE0J1H6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H65DRAFT_338628</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677116.1">
        <property type="nucleotide sequence ID" value="XM_062823604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1H6"/>
    <dbReference type="GeneID" id="87860758"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
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        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="107"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="308"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="463"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="383"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="508"/>
            <end position="512"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3334950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="547" mass="59832" checksum="59068F953F4D22B6" modified="2024-05-29" version="1">MAQHDEHILAASQKHAIVPLEKGQLYKYGTAGFRMKADLLEGVTFRVGLLASLRSRKLNSQTIGVMITASHNPAIDNGVKIVDPMGEMLEQDWERLATNLVNAPSPEALVQYYNQIATELKIDLSAPAKVIYGRDTRPSGHTLVTALAAALDATETEHVDYKILTTPQLHYLVRATNTEGTPTSYGEVSEVGYYKKMADAFVRALKGRRINGPLVVDCANGVGGPKLAEFLKHIPKDKVNWEVKIVNDDVLRPEVLNLDSGADFVKTKQRAPPKPAPQPGVRACSLDGDADRLIYYWIDPDTGFFMLDGDRISSLAASFIGDLVQSAGLQDELRIGVVQTAYANGASTNYIRSHLKLPVMCTPTGVKHLHHVAQSFDIGVYFEANGHGTVLFSPDALRAFKTTEPQSPAQQDALTTLAALSDLINQTVGDAISDMLLVEVILAHKNWSLRDWAMTYNDLPNRLVRVVVGNKDLFQTTDAERRLSHPEGAQEQIDAAVKKYKDARAFARASGTENACRVYAEAATNSEATELAKQVAQIIERFGGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1Y4</accession>
    <name>A0AAE0J1Y4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_446713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825811.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87862965"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3335035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="118" mass="11585" checksum="32D37E825A6A6462" modified="2024-05-29" version="1">MSPFWHTFLNRNFPDPQNPTIRERETTSPAFTMSSYGKHGAVGGGCWSSSASSTSGASGTSGSGNVSEGIISNPSSGSSSSGGSTTTVGGSTTSQGTQGSSWGSSGSTGSSSSGSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J745</accession>
    <name>A0AAE0J745_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_434796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677637.1">
        <property type="nucleotide sequence ID" value="XM_062825154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J745"/>
    <dbReference type="GeneID" id="87862308"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="60" mass="6593" checksum="5023B19E044E9752" modified="2024-05-29" version="1" fragment="single">PLRNAWVFPTEYSSIEIPHLTSYTGARGQSTGAVHSPILYLLHPVNKIDGAASKLLHIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J763</accession>
    <name>A0AAE0J763_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteinase inhibitor I78</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_477916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677605.1">
        <property type="nucleotide sequence ID" value="XM_062827458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J763"/>
    <dbReference type="GeneID" id="87864612"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9070" checksum="36C1A26026648731" modified="2024-05-29" version="1">MPLVVPGVTTNDPAVQKTEEWMNKLCGKTLADHTSETTFCKKDLPEQTRIIEPGSMVTKDFNPDRLNVHVGEDGKVSHVLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7V9</accession>
    <name>A0AAE0J7V9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0H65DRAFT_326297</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678008.1">
        <property type="nucleotide sequence ID" value="XM_062823475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860629"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein,Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="792"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3338557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1531" mass="168586" checksum="78C4C43C6627BE4E" modified="2024-05-29" version="1">MASTQIKTPQEAVARIAYLASDVVVSVQPSLAAESDFSATLKSLASSRTQSLASKAADAVTEIIPVRHNNDPLLSVFTPIRSGRLVSVTTTSEILLSSIAHLYKLAQLPVVLHVALGPKSLPDYTAITSIRNSGWTFLQSNSLQEAQDLALTAHALAVHSGKGVIHFFDPSSSASEQPIAAEDISLVQEILNLDNVRRFQSASISGSSIYANDGRVAVAPEQFEPVASQTVLDAQEVELAPAQDGADESAQTSQQQSEASEASEASATPSASIATTIEEQAPVVTSEHIYKYVTSIWAKLNELAGRQYSAFEYSGPSNAENALFVFGSGSPLFAQAIAQAQSDDSFAKAGVLTARLYRPWLGAKLLEAIPKSVKRVAVLEQVSRKTTKWGPLLIDVLTSVKSGPGGVETIVGHQLGYISQETVVQALRGIFQNLTSEKPVQNLEVGEREAPKEASEYGLEKPKLETAYTKILDQLFGERAYIANSIEKDNAGVSNTISATPEYGFGALLARKERKQKFVSEVKEAASNGQFSSDAPKQALAKWVANAEDAKKVEEVASEAVSKLSEDGSDLSKSLLEYKQFFRKQSLWLVGSDAWSYDLGNSGVHHVLASGENVNLLIIDSTPYSERAAADANRRKKDIGLYAMNFGNAYVASTAVYSSYTQVLQAMDEADKFNGPSVVLAYLPYFGEHDSALTVLQETKKAVDIGYWPLYRWNPENEKKGESNFSLDSERIKKELKEFLDRDNHLTQLMKKEPSFGAVLSEDFGTEIRAQQKRKAKDAYNQLLEGLFGAPLTILYASDNSNAISLSKRLGNRGRARGLKTTVMCMEDYPVEDLASEENIVFITSTAGQGEFPQNGLSFWHAVKDNTSLDLANVRYSVFGLGDSHYWPRKEDKIYYNKPAKDLDRVLANFGAKPLAPLGLGDDQDADGFQTGYSEWEPKLWEALGVANVDGLPEEPAPRTNEDIKLESNYLRGTIVQGLNDTSTLAISPDDGQLTKFHGTYMQDDRDIRDERKAQGLEPAYSFMIRCRLPGGVSTAKQWVQMDDIANELGNETMKLTTRQTFQFHGVVKSKLRPAMKAINRALMTTIAACGDVNRNVMCSPLPAHSKYHRAVWECSKRISDHLIPNTTAYHEIWLTDDDGSKTQVGGNAVQDFEPLYGPTYLPRKFKVSIAIPPHNDVDVYAHDIGLIAIKNEDGSLAGFNMTAGGGMGATHNNKKTYPQVGRMLGFVTAADVHIACEKVMLVQRDNGDRKNRKHARLKYTIDDMGVEVFKAKVEEYWGQKFEEARPFHFDSNVDTFGWTKDETGLNHFTMFIENGRIEDTAEFQMKTGLRAIAQVHKGEFRLTPNQHLILSNVTDEDKPELEKLLAQYKLDNLHYSALRLSSSACVAFPTCGLAMAESERYLPVLITKLEGVLEEVGLKQDSIVMRMTGCPNGCARPWLAEVAFVGKAYGAYNMYLGGGYHGQRLNKLYRASIKEEEILTIMKGLLRRYAKEREEGERFGDWTIRAGIIKATTDGTNFHEGVAEEEGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7Z1</accession>
    <name>A0AAE0J7Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_502724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678010.1">
        <property type="nucleotide sequence ID" value="XM_062827859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7Z1"/>
    <dbReference type="GeneID" id="87865013"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="489" mass="54288" checksum="48BD945CA7E7C127" modified="2024-05-29" version="1">MSNQQSLVDYLVEHEPSFRKARLPALYSDFTSLRTLNPDGYQANISAWRSALAHLARSGLAPAPKGSTPNLLVLNADESLLRALESKKYGRPLALGTVVREALAAKDLMPLHDFLTTKTSIYYKPWLPSPLGIAGGVAGWALKQLGVAEWLRSHSLPKGQFVVVANVEEAGKQFAATTASALTDSRFERTWSKAHFLQTYNEQVQLESGSDAKLLTETDLDVLLVFLSRDKDVILYDGSTFKIKAPSDDAGQHQQQQITQEDTTVASIKELISSLTHQTHLLAGRISELDKTARQAVQSKNRIAALAALKQKKLAEQTLEGRYASLTQLEAVAAKIQQASDSVAMMKVMETSSRVLESLNEQVGGVDRVESLVDKLRDQMAEVDEVNTILAEAGTSAAGVDEEEIDDEFEEMLAEQEKEKKAVEEKKEEEREEEREREREQEREAEELRRRLEAIGGVPVVEPGTGSRREREREMERLMKGMSLAGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J816</accession>
    <name>A0AAE0J816_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_552466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677407.1">
        <property type="nucleotide sequence ID" value="XM_062829891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J816"/>
    <dbReference type="GeneID" id="87867045"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3337956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="173" mass="20185" checksum="2344AE330E1442BA" modified="2024-05-29" version="1">MADPEKREKRNAKKREYQARDAETKDEINKKRRQKYAEKKDEQKDAKTKVKNSKEPAKKLKERQVELVAVEIDQIGNAQKGLRLTPRQAGAAMASNMHTEAKRSKKDEINKKRRQKHAEKKDEHNAKRREKRATNTDEDRDKQKEYRARWKAENPKKHAEALGEAARGSTKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J871</accession>
    <name>A0AAE0J871_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_474643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678129.1">
        <property type="nucleotide sequence ID" value="XM_062827254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J871"/>
    <dbReference type="GeneID" id="87864408"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="189" mass="21100" checksum="C7BE6D3F33C46DB3" modified="2024-05-29" version="1">MFKIDSGLSSRPVDEEDGPPGQRASIHGRMTSVRVSAETTRPSSPGRTRHTTTPARHLLSLAGHRSHSPWQYGPGLSYGVRSCHMSLGSRTMPVFWSRHRRASWPFCASFKRCWLFACESSLQCLNAETPLRNSSGPSVIRYFLIRVVWYPAAGGWAVLVLLGIRLDTVEILLRGDLLGRDAAQHKFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8A0</accession>
    <name>A0AAE0J8A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_445135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678218.1">
        <property type="nucleotide sequence ID" value="XM_062825720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8A0"/>
    <dbReference type="GeneID" id="87862874"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="115" mass="12748" checksum="C87FD99F48836D48" modified="2024-05-29" version="1">MNRGVWTRWLLGLGKPLKVSGDWSSWSRGGESRRTGGCLDGKFRRDFEIAFLSIGSFFVVDVLLAIVEDMLKGAIQVLSFTFAEILNRVVAGQSAVGTRFQRCADSGSNRRHHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8A4</accession>
    <name>A0AAE0J8A4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_445178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678269.1">
        <property type="nucleotide sequence ID" value="XM_062825723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8A4"/>
    <dbReference type="GeneID" id="87862877"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="150" mass="17095" checksum="A169142B461F91BB" modified="2024-05-29" version="1">MCVTIPAQWNSSFREVYLNVLAEAFDIHRETLRLQQLAEDAGLPRPHFERDIHDREQSSATRAGDHLRLVCDPFLGQDFKFDGWNNAVPRPTYKRTYDLLDDLPVPTSNGKFECQIDFRNKHVESGGMMILKLKIIPEKAKGQGASPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8E2</accession>
    <name>A0AAE0J8E2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_579734</name>
    </gene>
    <organism evidence="3 4">
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    </organism>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121087" checksum="49C1FCDE0ED03467" modified="2024-05-29" version="1">MASQRPQRNRRPPVFYGHEEEDTFTDFEAPSHPRRPIDTRLPFDPQLVEECAFPSLDPVTHGGPGPSEVYKVYRQVRREQEIKRMVEYGPWYHERIAILSLRKQVVGRRDVGEFPGDAVDNRSRGRSRGVSVLYADTDEDRRRWEKSREQEFLWAVGESSSEGEEEEEEEEEEEEKEEEEDKIQQRDMDVRTSRLMFSVRNTNHKKQKEAVAAVERARLSRAQSQASSHGQVSPVLPLVSALATAEGGNQRDADGDTVMGGGTVHVPPYSFAQLSTLLSLSSDEIISLLYLINQETRKMIVLDNLNRQLAAIEDINAIRDALDRLKPQGLVTDSVSSEDIRQGQAFLRFMGLHEVAEWLAEYMGVSNSWDDDEGRYVIKINGRLLDGDIPAEVAGNVLRRIWREEQERASRIENARRVEAARASMQPPPPGLVNRSVLELTDRSADNGNVLTVQEAEQAARRLADLELLVPESDHYTVSLNGESVHLEEGLQARRIWNEELEAMRQARRQNAMAPPARPALRSNQERQPSRPTLDQVAGSLVGNRKEHRQGVGETSRAEKRTHRDGQSRDQATLAQQPLPSTAAIPSAPVPMDINSNTSRTTKHDKEQQRKGHPSSSANEADQETQSRNSPTNDYLLSIGIDLSLHKPPPVETSSGSPTLEERTAAFLAANKATLAAIDKEDEKEARRRRRQPAQVHAHDDEPTIPAYGLRNVSEARTLRSNSVYSSRLPSKAPSVVPAAPTTIRTTRGNRHASTVANPSSSAHETRRGQEGMSREEGPGQPVEERSQNNRVRRDARRQVKNPETAMEREPEQPRKPQAATEAGASNDTPHRYALAGDGSSRPVITAATTQKEETQPVAVATPPAPKTPASQKKTKIILKIGGRRVSQPSNTLTNTPRSEPMHTSPLTLGRNFSEPTRRHRELSPERSIGGDATLDATSRSSFNQSLPTRRNLFGTTREQEHSSYPTSGTPTAPDHIQSQAPTPSLGVFRHPPKAIPQQSHLQMPSTATFRNCPLTESGSHHQTELGPAGPLPSVTPATIPPAQTISPQVLSQAVAGRESQQTMRGRATEELGKRYATRSQVHGEEQGGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9F3</accession>
    <name>A0AAE0J9F3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_289836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678446.1">
        <property type="nucleotide sequence ID" value="XM_062822992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9F3"/>
    <dbReference type="GeneID" id="87860146"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="551" mass="60327" checksum="C19D529F4B8CBEC6" modified="2024-05-29" version="1">MDSSPSATKTFSGMEPTLPSVAGIKRPAPSLLPPFEPLSSSPGLPRPSKRQATSNAFLKYPTPIPTSSTGILSSSPPRVGYNYGYAAPYMAPRPGLQRTLSTVSERAPLSDVRAVVLNENGETLLMGRSSNSSHYQLSSNRLVSRVHVHARYIPATEALEPNKVEITCTGWNGLKLHCQGQTWELAKGDSFTSETEGAEIMIDVHDTRVLVQWPPREKDRDSSAPLSDSSWDETPRPMRRGRRPGSDSDEGSPIRRPRRISSPESPTPANGSTSKADLDDLLSDNDDDGAAVEIYEDEEEDEQELPKLTDTGRGDATFITIVDQSFSMSSDLSDPRSDEDYADQDPDEENDPIIPSFGPCGENLSSRLESFTTATSPPRARTPDRDYSGSSDEERAGSVTPKPLKSSSGNAAGAARKASPTPAPRSPSPVSNLSEELTATISNHVINQLAFSRLSSTPLSTIMNNLPADDRRQVTKDELRRLIEATACIGIIERQGKDAAGKPLESEYYYVPEFDTDEHRRLAVTDGLRKPSLRACRKQHKQYYWKKPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9K0</accession>
    <name>A0AAE0J9K0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_511699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678864.1">
        <property type="nucleotide sequence ID" value="XM_062828509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9K0"/>
    <dbReference type="GeneID" id="87865663"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="731" mass="83311" checksum="37EEC7F9A825B0CE" modified="2024-05-29" version="1">MRMHILTPARQPDAHTRRQVQTQSTRDRPELPVIPLDAHCGICNEKIDRDVFVTALIGKRGRMTYLGRTIKFPFPIYGTYLPSPDGIDAYLDRKKSFHFCYLCTDSTPWKECLSNWKHSSHAFNNPYEAVTTHHDCFSMFIQSCPLPPRLACERLWKVAIARRPWPLGYQDLPSISLTGAYHVLCVEAVRKVASIYNIRQLTNFPTELVERIRSYSPGEPVFWRAVTALTVALSLSNFPVIDEQRVELTKVSHWERGGTIQTSGPEGRTTDVLRITFDIDGVRKIERLPRWPNCEKQLKTDERFAWVILEIDGVEIRDKMAYCQGGLLRFSWGDTSRALAHSIPPMIWDTPTPPDLHNIEYNADKFYFPFFGGGYGGSFEAGHLINLDSISGLTFVYEGKELTAIHSHCGDAINNFGIPVGSRYGQHQACFFLPVTKEDKIMAIGIGCYPRALVIVVKKRLSGDTVIGLPCPNPITGQEISVMSPDDTEFEFLAGPTEGDEEYFDPRHFHWGAREPQALLYGFQGKRNQLDLLGGYRYDPPQNWVPGWKPRLQGRSIPHNWPQNNLFSRDNQEDLRFYTSAPLEGVISAQMFYSRRFVPRGGEPFCSGIIFHYENGGSRVVGEVRLINDRASIAGETIIHPKLICLEWPKRDGSSISQRIRFLTEADIEKGVHPVHTNPRLGKCTRFPIVKESVCYPMEGTIDWWFTASERMREEEDTQEGESQEEDIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9M2</accession>
    <name>A0AAE0J9M2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription-silencing protein Clr2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_475739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678571.1">
        <property type="nucleotide sequence ID" value="XM_062827324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9M2"/>
    <dbReference type="GeneID" id="87864478"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="74"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="398"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3339211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="589" mass="65795" checksum="241F31ADBB8617C5" modified="2024-05-29" version="1">MVTMSASNGQDDDKDKNLYLGLRIARSDGKGYDNLDHNALDPKEDQDVAQLERWEVIIGGHLQHQLGLPSDKQYKLAVLPKGYELRCAIRKDGGRDYYLYGHPAGRKAVYRTPGDFVLHALFLLSKHADHSQCSCDLCGKMIESQKLRQADQQHAQRIQQVLGQKQRQQQLEQQQKQQEQQQKEQQQQQQQQQQQQQIQQVQQAQQAQQIMQQNQQQQHQQLGQQQAQGSLQSQVFAAPGVTSLTNVFRAGELVWYKHQAWRLGVILSIAPKRQTPGPAPDAAFNFLVAPLGHRTLGQQSFYIDAKSMRPFLTFSVPGVGENFSSLANRTYDSIDWPTFSVQYCQSLGLTDPSQLDIARQTVGLEASKLAAKYINDCYSTFNKLNKSNASGVQDTVFHEGVYLGAEMIRVGDPVRVVGGHVGNGHNNGGAEANAVMLVSEIVTDAHGMNIRFKGNLFQTVRSVPPMPPNVVTPESLGQVFIEEVMSRNEIEKYNKARWGWALVERDAVRTEVDTLGRFYVTHRLMNIIDPARFTASVQKGVVEDAHAYLNNRAHSGSGRFNGPKATRADTLGLAVNAMFAAPEGMDESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9P3</accession>
    <name>A0AAE0J9P3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="14" type="ORF">B0H65DRAFT_531780</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9P3"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000005">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="12">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="171"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="11">
        <location>
            <begin position="388"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="174"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3339495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="494" mass="53837" checksum="FE6F269825C02862" modified="2024-05-29" version="1">MSIPGLGQIAPQAPTSTQRTINLRPFGEWRFSIPHQHSTFSSNSSAAGVTVRLVAGTAERDGTELAPNCVYTFLPGTKSKLFTDQGCTLEINNTGGYPLEDRVVEYPSPEQSPMLSYLNLHFGLQDHERAAAAHAQLHPTHHLQQQQQQQGRGAGAGATRPKPGPRVLVCGPRCVGKTSLVKLLAALATRMGSQPLVANLNPTDGLLCLPGTLGAAVFGTLMDVEEPAGGFGVTNTPISGPSAVPVKNPLTFYFGREKVEDDVDMWRQMTERLAVLVKRKFERNRDVRVAGLLVDTAPVEAGDKEGQELLGWAVRQFDANYVVVLGSEQLKTELGQQFASEKTSFGEPITVLGLDKSDGAVQIDKGWRQKSTETAIKEYFFGGIKARLSPFTQSASFDELVVFKAPEEPYEGAPVLERVEITPEMAHWTLAVMIASVTDSPQAIRFSSVLGFIVIADVDQERRRVKFLSPVSGRLGNHPLIWGRWPEPYLNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAA8</accession>
    <name>A0AAE0JAA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_303809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3339571.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062828417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAL6"/>
    <dbReference type="GeneID" id="87865571"/>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
    <sequence length="134" mass="15122" checksum="A730B853023FF7FF" modified="2024-05-29" version="1">MPAAGAQEQIRKCRTIKAYETQNRLKCAKPRGQQSLRERSTTTIRCLLIQHLFVAETSMRCAGTRTDRHLCWRSVPPDDRMGDSSVKSGSCGRGLLWTVLSCCVRISRKQIEKLEACTALMRLREGKKHDACLA</sequence>
</entry>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679515.1">
        <property type="nucleotide sequence ID" value="XM_062828423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAW4"/>
    <dbReference type="GeneID" id="87865577"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="146"/>
        </location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679737.1">
        <property type="nucleotide sequence ID" value="XM_062828438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB39"/>
    <dbReference type="GeneID" id="87865592"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="44560" checksum="BBBBA5A28040A920" modified="2024-05-29" version="1">MHMSLHKYILDPSGLPPLLRSVRGALFPNNLPGTSSLTAPLSEDELLALRRRCAKDLWALISPGFMAKLVGSVYFGGRSGFGGNSSSKARAAGLKTTRPVANVSTGTTNASMVVGEEDAKRGVALAGASRSTTSRGASNAGSATVQPAAPQNSSQKQVQVQVQGGQTQMEQMRSGSGPKKSGLDQGQQAVVPGSAAASTTGGPVPAHQQGSGSSGSLSSLLSVAPAPGFGPGSGRRGSASPSVTATASAGIAATTTTSSDPRSGSSSSSMGNSRSSSKLSLTATGGSQKSAVGNGGNGGNGGGGSTNDAAIRAAASATKTKLAKRVEDQHAHVDEAHRQQELDADVADADAGAGDDHAAASAAGGQAHVDETEIDEVDEDQNEDEETILTEIEQGILDVFSDAYLNKHLIYSMLELILVRLMPELAEKKVSELWEERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB41</accession>
    <name>A0AAE0JB41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_432082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679724.1">
        <property type="nucleotide sequence ID" value="XM_062824977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB41"/>
    <dbReference type="GeneID" id="87862131"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="77" mass="8682" checksum="47BCF081F6DEC393" modified="2024-05-29" version="1">MSAQAQPTGSRPDARLQRRLCNYNETGGTKGVINEPEDESVDTECRTRESRRRKRGKNQKCLSSCRCNPGYNSPCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB83</accession>
    <name>A0AAE0JB83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YAP-binding/ALF4/Glomulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_473196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679628.1">
        <property type="nucleotide sequence ID" value="XM_062827187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB83"/>
    <dbReference type="GeneID" id="87864341"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="663" mass="72827" checksum="94252C3F2E736462" modified="2024-05-29" version="1">MDSEKAIAAIKEAKPPATDRFTYLTIVETNISPAVLPTLNEVLQDAELTQEIGWDLVYNLVNLPGSDECLETIARLGNPREVILKVLETLELLSQDDGYQSDDESEAGETNGEKSVPFKQKFITLVNMLSILHKRIKTKYPSRFLATSLQTIYSTYRPNHEMTAAVINLVRSLAGNKRPPLPTRKSSVNVANPDQHGDATKNAPDPEADKVTEDPTETAIQERLLLSFATCILESFVNKNDVAWAPRLLEFYNPEKIVPGRKTLMARFREEKELSEKDGAVGQLVALIADLGLSSCDKTFLSQVSEGPLHTDPLSKSEDISKPEDIGLLTGGCVILLAYWVFSTTVFDSDHPVPDMHIFPNHLAMLEKFLQDDAEDQILKAPGTVQALVTIGLWLHDKGLISEIPKASLVNQTTSPDGPTSDYMSYILCVTLIAVFHPQLHVRNAASCLAGLVLHADPADDDRLKILYDLLENCDYASLKACAITWLREELIAAAPNAQAAPQNLAAPNNQAPLPSPTLQPGAATPGTRSRAGTNMNVFAGPQALETVQYVVFPNMDSLKELDLQELVQNLGTNAPFFLQAVNFALFLWSSADKWRRVLPPNLDATVKERWFAPLKDAVAKVKKAVDSGEVEGRELGSLQFDLDVLGERLSRLEAAEGFAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBC0</accession>
    <name>A0AAE0JBC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_472720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679468.1">
        <property type="nucleotide sequence ID" value="XM_062827159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBC0"/>
    <dbReference type="GeneID" id="87864313"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3340526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="501" mass="56859" checksum="35DC63968D5C8715" modified="2024-05-29" version="1">MAEIYPSLVQCAIVAAAFKILLFPAYKSTDFEVHRNWLAITHSLPLWDWYYENTSEWTLDYPPFFAYFEWIMSQVAKLADPAMIWVHNLEYDSWQTVYFQRWTVIVTELVLVYALQMFVDSTHGVSKRAAQAAAVSILLSPGLLIIDHIHFQYNGVLYGILIASLVLAKKKSSLLASGLVFAALLCMKHIYLYLAPAYFVYLLRVYCLSPKSIFRIQFFNCVKLGGGIAAIFAAAFGPFALRNQIPQIFSRLFPFSRGLCHAYWAPNVWAMYSFIDRVLISLAPRIGLPIKADALNSVTRGLVGDTSFAVLPDITPRMCFVLTLLFQAIPLIKLFMRPTWEGFIGAVTLCGYASFLFGWHVHEKAILLVIIPFSLIALKDRRYLGAFRPLAVAGHVSLFPLIFTPAEFPIKTIYTIFWLVLFLMAFDRLAPAPTRQRLFLFDRLSTAYITVGIPLIFYCSLMHGIIFGKSYEFLPLMFTSSYSAIGVVGSWLGFMVVYFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBD6</accession>
    <name>A0AAE0JBD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_472726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679471.1">
        <property type="nucleotide sequence ID" value="XM_062827161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBD6"/>
    <dbReference type="GeneID" id="87864315"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="154" mass="16716" checksum="404DDE24DA936307" modified="2024-05-29" version="1">MKELGLLSLSENSEESGEGDGNGSGDGVTGAVVWPWKSNNGNDDNNNNKKIEKLIYHYPKDKPITESNVKQWGLDLYLGRVKSWFPPSSSSNDEGKKGEDGNGSGSGRDEVLRDLKNRVRVVKGGKKATRKVMKRTGSGSIPGVKIRVAGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBG9</accession>
    <name>A0AAE0JBG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_264204</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679531.1">
        <property type="nucleotide sequence ID" value="XM_062822665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBG9"/>
    <dbReference type="GeneID" id="87859819"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3340589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="181" mass="20882" checksum="C743ED0929CBB241" modified="2024-05-29" version="1">MLSILRKAKLKDKELRILMLGLDNAGKTTIVKKIMNEDVNTVSPTLGFIIKTIDYEGYKLNIWDVGGQKTLRSYWRNYFEKTDALIWVVDATDRLRIQDCKDELHGLLQEERLSGASLLVFANKTDVRGCMSEDELREALQLDEIRTHKWNILRCSAMTGENLKEGLAWVVEDAKARLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBN1</accession>
    <name>A0AAE0JBN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_214415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680022.1">
        <property type="nucleotide sequence ID" value="XM_062821975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBN1"/>
    <dbReference type="GeneID" id="87859129"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF106">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="309" mass="34730" checksum="B48449FE9CE3C41B" modified="2024-05-29" version="1">MPLPSKSSDLILVHHNPIKDSDTQLTADSLRRLSTVSADSDYELIHFGETQAEAEDAVSDDDNASTASDNSHISLTPAFYHHHISPYGRRYHGFQSSCGYILPNDPPEQDREDFLHLVSLGLTYRRHFLSPIGDNLNKILDLGCGTGKWTVEVADKFPFAKVVGVDLSPIQPVMSPENVEWWVDDVEDEEENFFETEGNDYDFVHARYLLPMIVDPAGLIGKCFDHLKPGGWIETQDLHPRINSDDNSIPAKETYPPGQFMDLANIAWAQAGTDYRITPQIGEMMKEAGFVNVTCRQFKVPLGPWPRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBS0</accession>
    <name>A0AAE0JBS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_401523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680082.1">
        <property type="nucleotide sequence ID" value="XM_062823785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBS0"/>
    <dbReference type="GeneID" id="87860939"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="136" mass="15843" checksum="B35E7316DD2E9062" modified="2024-05-29" version="1" fragment="single">VRRWLTACLEGHDECSNWRSILVDTYNYQHKIRFIDVGTVEEPIFRLVDGQSLVNRTGGIQYVTLSYRWTAETEITSMKSYNKASYQDSIPTYRLPQVYKDAAAVARALGVRYVWIYSLCIIQDSPEDWNEQSSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBX6</accession>
    <name>A0AAE0JBX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_408994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680125.1">
        <property type="nucleotide sequence ID" value="XM_062823825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBX6"/>
    <dbReference type="GeneID" id="87860979"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="283" mass="29824" checksum="E48E708169365896" modified="2024-05-29" version="1" fragment="single">MSTPSPPRAPKPSPPVMMPVTPLPDTLCVPPPPSTTAQSAKRARTADEEVRHAHTTATATTAGPILSFAGSLISEALARAEVYCSFAATLDSELARFSVVSPAHAREADRLARTITAALQKNSASSPPSPTLDLPSSTPDSTDPVNTRKGPVTFAEIAAKGANSASASRSTSRSSRSRSGSTTHASGSTRKAAPPPTSPQSDGRVFLRLDRDSPFTDTDAYAIRKEVQTLLHLAPTDIPGCHKVPTGFALVPKNDAVRQTLLARKDEISARFGCIQVEVPKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCI1</accession>
    <name>A0AAE0JCI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_443467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680457.1">
        <property type="nucleotide sequence ID" value="XM_062825635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCI1"/>
    <dbReference type="GeneID" id="87862789"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="295"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3342664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="472" mass="49770" checksum="AA4F196BE8BF63DA" modified="2024-05-29" version="1">MGILPKGLSSVLAKAPTDVVILSSLRTPITRSYKGHLKDAYPEELLSVVLRATLDKVPELNPSNIDDVAVGVVLSELGGSKAARMAMNHVGFDSSSTSLYTVNRACSSSLQAIASIAASIRTEAIDVGIGAGMESMTRNYGSRAIPTSYWPALKESPVKDARDCVMPMGLTSENVASRYGVSREDQDAFAVKSHQLAAQARAEGRFKEEIVPVTTQYQEVDKQGAKVGEAQTVTVTEDDGIRPTASMEGMAKLKPAFKADGTSTAGNSSQVSDGAAATLLMRRSTATALGLGDRIIGKFVAANTVGCKPDEMGIGPAVAIPKLLGQLGLENKDVDRWEINEAFASQAIYCLRELGLEEAWKDGKVNPDGGAIALGHPLGATGARMVSTLLHGLGRTGGEVGVVSMCVGTGMGMAGVFVREYLPSACLPTCSACSASRQTTYREPQIATQAEIDILFDPLLGTHVERSFRSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCN1</accession>
    <name>A0AAE0JCN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_549767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680363.1">
        <property type="nucleotide sequence ID" value="XM_062829686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCN1"/>
    <dbReference type="GeneID" id="87866840"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3342570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="342" mass="37789" checksum="E7D760978096548A" modified="2024-05-29" version="1">MSDFEFFKYDPSLAANAVFVALFGITAVGHTFLLVRNRTWYFIPFVLGCLFEAIGYIGRIIAAGQTPNWTLAPYLVQSLLILLGPALYAASIYMILGRLIRMLEAEAYSVIRVNWLTKLFVLGDVLSFLAQGAGGGILAKASSAKDQDLGNNVVLGGLGIQVFFFGLFIITTILFHVRIAANPTPKSHSVTVPWRQFLWALYVTSSLILIRSLFRMVEYALGWDSVLMRREVYLLVLDGMLMVIVSTAFLWYHPSRILVGYKQVGMRSVDLEGTTVEGEYTMTSYGGGQQSPSPSPIPSANLKAHDSRQSSSGGRNSLMLGQGKHHRQTPSDDVSSYTPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCV4</accession>
    <name>A0AAE0JCV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_589830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680639.1">
        <property type="nucleotide sequence ID" value="XM_062831049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCV4"/>
    <dbReference type="GeneID" id="87868203"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="86" mass="9014" checksum="F791199DA9D96F84" modified="2024-05-29" version="1">MKGNDVIAVIIIVLFIVLAAIAFGIYRLVSVARQAHGTVTTSSSGSSTSLTDDDEHSHSRGPTKLLGLGYQPGYGFCPAGCSVFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD20</accession>
    <name>A0AAE0JD20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_234337</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680727.1">
        <property type="nucleotide sequence ID" value="XM_062822232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD20"/>
    <dbReference type="GeneID" id="87859386"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="155"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3342934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="365" mass="38760" checksum="72B674D89AFD3CB9" modified="2024-05-29" version="1">MASARQVNIAIIGAGGVGKCFLSQLEWLAARRQNQKLVLTYIATSKKAVYSDSYSPIALDSVVSTLSSSSQAPLALPKLVDYLAASGTKTVLVDNTSSQDIADAYPSFLRRGISIVTPNKKAFSGSYKLWQDIFAAKEEGGALLYHEASCGAGLPVISTIKDLVETGDEVTKIEGVFSGTMSFLFNSFAPTSGAGGGKWSAEVAKAKELGYTEPDPRDDLNGLDVARKLTILARYAGLEVESPTSFPVQSLIPKELESVASGDEFLTRLPEFDAQMEEVKAEAQKEGKVVRFVGSIDVASKQVKVGLEKFDLSHPIAALKGSDNIISFYTKRYGSNPLIIQGAGAGGDVTAMGVTSDLLKVLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDG2</accession>
    <name>A0AAE0JDG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_509566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680257.1">
        <property type="nucleotide sequence ID" value="XM_062828329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDG2"/>
    <dbReference type="GeneID" id="87865483"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3342464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="141" mass="15838" checksum="74D21DCF968AC55E" modified="2024-05-29" version="1">MPVPFEALIPYAIIVTMFGVTGAGLSAIKTAQNGGKKARWSLDTWDRYEPLIPANYTMMDRDRRLTGWLRGQTDAADAPYGFEYNNPWRQLPGRKVERIIERTRLTHDITTTAPTTLTVTFHDINTAPCSDHTSRAGKQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDV4</accession>
    <name>A0AAE0JDV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-keto-steroid reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_576834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680833.1">
        <property type="nucleotide sequence ID" value="XM_062830669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDV4"/>
    <dbReference type="GeneID" id="87867823"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000524">
        <property type="entry name" value="3-ketosteroid reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3343040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53261" checksum="F3D75562565DD31C" modified="2024-05-29" version="1">MAPAPWDSVPPEDTLFALVTGANSGIGFAICQRLIDEYLTTRSLTSHLVVIPTTRSVKKSQETIDALRQHAREFATTSDILRSRAGPNYDPRSVTKRIHILSVQLDLCNLADVHRAAEQLVNGTVSSPANDNDAYFTSLTDVRIPRLDSVIFNAGMGGWTGLDWPKVFHNIFTKGLVQATTWPTFKAATAGHVVNPLPDVKDEKVPEMGQVFCANVFGHYLFAHKLVPLLSRSESDSSIPPGRIIWESSIEPGWKNLELSDFQAIKTNAAYESTKRLTDVLSLTATLPSARPFVNSYLQPATKSSNSPATPPILYLVHPGIVQTTLFPLNAFMFFWYRVVLYIARWLGSPWHPITGYNGAVAPVWLALQEQEALDAVNAEHVKWGSSTDWWGECRVKKTEVEGWGWDGTVETRKELKNEKGERGMGRKIVGRKSGATDLTEEKRVEFEMLGVECWREMERLRGEWEGRLERVLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE71</accession>
    <name>A0AAE0JE71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-xylanase</fullName>
            <ecNumber evidence="8">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_241266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680921.1">
        <property type="nucleotide sequence ID" value="XM_062822324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE71"/>
    <dbReference type="GeneID" id="87859478"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
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                <person name="Kuo A."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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                <person name="Yanf M."/>
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                <person name="Grigoriev I.V."/>
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            <strain evidence="2">CBS 560.94</strain>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Ng V."/>
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                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="2" key="2">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681217.1">
        <property type="nucleotide sequence ID" value="XM_062828226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFA8"/>
    <dbReference type="GeneID" id="87865380"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="442" mass="47933" checksum="888EF30D79423332" modified="2024-05-29" version="1">MLRLRPTVLALTMAEVQEVEDRRRGYRRVSSKRKWSFRTHASENATSVASSPSLPDYSDSDEETDIPDHDSAEQPVQLPVLPARFPEEQTELIPTARPPCPNASCDQRNCEQSVDGAGDERDVDQQPQASSSQSQLPIRTPRPGPRIGSSLRSPAQSSVGQTAAASQETTPRTETSSARRSNRGGARSFEQFELSFQNLTIRTRTATPSSAAKPDSASRPGEGHCQGTTPNATPGSRTTSASHTPSAFVRFTRSMTATLPRHGSSPSERLERLASSRTRTPAAASPTSVSTSSTRPAPVIESPTTPSRQPVTTPRPPATTPARTPATFRVYNDSLPASSQPRTPQNLPEARHQSRLLRQGAYTVPAGWRTSFSQEQRTPTTSRAQRRLRHGGRREPSPQGLRTPGMVGLYGGTENHTDDGVVFVDVRAEGVDEPEEAPLAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFZ8</accession>
    <name>A0AAE0JFZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_201342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681881.1">
        <property type="nucleotide sequence ID" value="XM_062821792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFZ8"/>
    <dbReference type="GeneID" id="87858946"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="2">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="235" mass="25574" checksum="8AC80608B15C3734" modified="2024-05-29" version="1">MTTKTLCRACHRAARTTTTSISARSTRGLSQPFTTETFPQSTARGGSSKLPPPPQLDPSAILSTPTWSVRSLLPPSRPTSSTPSSTQPEESEITPQTLTHLSRLSALPPPSASDPSSTARLLSALHSHLHFVRSIQSVDTTDPSSLEGQELAPLSSIRDESPEGLAEITIDLKTLEGALAEEDIVGHCRRPRRRKAEEQLTKEKKKNEAEDWDVLGCAEQKVGRYFVVRSGKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG96</accession>
    <name>A0AAE0JG96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_425427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682183.1">
        <property type="nucleotide sequence ID" value="XM_062824574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG96"/>
    <dbReference type="GeneID" id="87861728"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3345570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="275" mass="31400" checksum="4F5C1FAFA8C9D304" modified="2024-05-29" version="1" fragment="single">RECVICRDHFRSDEVATVPCHHDYCRPCLVSLFTAAMTDESLFPPRCCSKPINLDQCRFLLGPQLVGRFLAKKLEFETPNRTYCSQPTCSFFIPPLFIRQDVATCVKCGHKTCGLCRGQAHTGTDCPGDPAAQEVLAMAEREGWKRCHSCKRMVELKYGCNHITCPCGAHFCYACGDIWKTCRCEFYSEEALMAQANRHVNRDAGAGQLPGPVRQQRVAAAAQHLLENHECAHARWTGRGGRFQCEECYDWLPRYIYECRQCRLLACRRCRFNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGF6</accession>
    <name>A0AAE0JGF6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_521390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682480.1">
        <property type="nucleotide sequence ID" value="XM_062828748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGF6"/>
    <dbReference type="GeneID" id="87865902"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37615" checksum="D73D21971BBEAF4C" modified="2024-05-29" version="1">MLSYTATVILTCIRFFVTLPYQRLLIYNTVQPAQEIKKLASSGFKTGTTERAKLWIVIAAWRQRKRDELQFVAVAATVMTAIITASFSWPNVLSSHWTGPAFWYASLSLCISAIFLSSQQLSLLSLIENKDASESNVDKPECERPSATLTIRRHLRQILIEKIEVTQKKNNDKPELHTGEKSSMVMTTGSVGAGGRLGAGRFKPTDIEAQHEAGDEQLTAPSSTRWTFSWRVMFVWQCPIMLIAYSTVFYMVGLFVVVCTPVLEVRKWGLDSYVAVVYMASLGVSVWLFGFCSYGAYDYIHDNHGPGRHLLDELAQRISILSNGVIPKQKKTNVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHG1</accession>
    <name>A0AAE0JHG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_161273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683055.1">
        <property type="nucleotide sequence ID" value="XM_062821240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHG1"/>
    <dbReference type="GeneID" id="87858394"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="71"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3347973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="266" mass="30059" checksum="0FF8281E4D029CF8" modified="2024-05-29" version="1">MAPKRQRAPTSPIERANRKTDEEFISDYLQPSVTPTLHPSSPAQPPPPPPKPWTTKWPHPKTGTKYAISLVQSGKLSEEDLKACFDLIKETSYDDYQNSKDKWQPRKKMEEMKSPDLRYVLVKEDGSDGSIRAFTSLMPTYEEGQPVVYCYEIHLKPELQGSGLGSLLMGFHVIVAANLPPITKVMLTCFLSNKRALGFYKRHGFETDDISPGPRKFRSGKVVMPDYVIMSKPVPSEDKPSEDKPSEHKRPKTDTSRDHSLEDKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHP1</accession>
    <name>A0AAE0JHP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_148385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682492.1">
        <property type="nucleotide sequence ID" value="XM_062821038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHP1"/>
    <dbReference type="GeneID" id="87858192"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="197" mass="22470" checksum="7FC9C5A52FD76255" modified="2024-05-29" version="1">MISKPDSSSPSTTNPIPTTTSSHSEHLLTECSSRGRVSITTTTTTIEQTPRSTYYTQHTSHTMSSPQGSPAGRVNQSYMLVPNLHVPDPTVDEVELGSSNAWTVATVIEDDDLMFGGKPLSAWYEEDRRRLSSSIEDEEEIRGRQRDRVRFDDHHQHQHQHTHHQPQHYHHNQHHTVHHTHVAHTHHTTKKTGEIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHX6</accession>
    <name>A0AAE0JHX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_571115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682916.1">
        <property type="nucleotide sequence ID" value="XM_062830470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHX6"/>
    <dbReference type="GeneID" id="87867624"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="223" mass="24280" checksum="FDE74BA59D8C9D31" modified="2024-05-29" version="1">MFSGDDSFTWAGSTSTVVGVGVGVSKEKESDRMTVSAEMDQHSTLCTAPVDHRSDISRRKTKKHMKYWFGCGWKRLGVEVTVLDFIFFTPSGICNCCNGTGPKSGGLLIEIGFFCLPGIYQAKRSADLHLLRARFSSQRDVPSSEPHVHQADNIRKHLDISTDINASSTSPGISLGFKLPNPWPDTAACIPSNISTTAIFPSTGLTKSPTSFEAPSPRQEKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIB9</accession>
    <name>A0AAE0JIB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_168852</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683278.1">
        <property type="nucleotide sequence ID" value="XM_062821338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIB9"/>
    <dbReference type="GeneID" id="87858492"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="54"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3348196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="317" mass="33751" checksum="4100FA1114114E0D" modified="2024-05-29" version="1">MKEMAGQAGAGSEDKCPVDHKTRELWLQQAKQAKAAQEAAAAAGGSTTPSPENAFTTPVAPAPAAAVQQQPPTPPTQSQIPQPAQQTAVPAALPTSQPSSSSWSSWLPFTSSSSGSSAPPSTLAPPQSSLGEHREISSIPRAATTGPSACPSNAEQETGADTATGNWVYPSEKQFYEAMKRKGHDGASAADMKTVVPIHNAVNERAWAEILRWEKPFTGEGCGCAEGPKLQSFMGESKRMTPKARLNTLLGYTAPFDRHDWIVDRCGTRVDYVIDFYAGRNNDKAGAGKLNFYLDVRPKLNTWEGVKMRALGLVGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIH6</accession>
    <name>A0AAE0JIH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_441814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683363.1">
        <property type="nucleotide sequence ID" value="XM_062825548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIH6"/>
    <dbReference type="GeneID" id="87862702"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="139" mass="15499" checksum="97E5683F2511ED9D" modified="2024-05-29" version="1">MNLRAVPLSTVPTLKRLSCIFIEFEEEESIANLSKKAPKKATPKKAPKKATPKKKVAPKKAAPKKVAPKNKRKGKAPALEPSLELMPSLKPETEAEVTSVPSFPLIRLAPIEFSSNSDSEFDNDEEKEKEEEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIL6</accession>
    <name>A0AAE0JIL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">B0H65DRAFT_159491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIL6"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="100"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="424" mass="46992" checksum="5EA80CD895896061" modified="2024-05-29" version="1">MVRHKKDGFSSRGGKGGHGRHPPRNNPRAGKAPQDGAGSGGEDTTANPHDPSASSRPYRPPFKAACWDLGHCDPKRCSGKKLMKLGLMRELHLGQRHSGVIITPNGKRVVSPADKELMEQYGAAVVECSWARTKEVEWKKVGGKCERLLPYLVAANTVNYGKPFRLNCVEALAAAFAICGHLEWAEEILAPFSYGRAFLDINSKLFKIYSACKDEDEIKKAEEAWRERLEKEYTESREGESDDIWTTGNTNRRPAMDDSDEDEDDEEEEDSDEEEDGSDQDGSVDGIYLGTKPPPKQKQPAASDDEEEEEEDRDPFAISDDSDDEAEMEAIRRKILASKSFANPEPPKKTVEMIARPQGQYKPDSDAEPDSDNGEEDDEFDNIIAATPVTDRIGLQKLEKERTRATVTRGTFSSASISAPRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIP2</accession>
    <name>A0AAE0JIP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_461903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683047.1">
        <property type="nucleotide sequence ID" value="XM_062826619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIP2"/>
    <dbReference type="GeneID" id="87863773"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50557" checksum="1D2B655F00F7CB12" modified="2024-05-29" version="1">MTTNKRDHLPSLLLLPFPPHPSNRTLLNAAYRPSLTAVLSKLKHSNPHGASKLIVAVAVPILQGPPYQLRSKTLLWSQAQSLVAGLYAIISVICARLGISTEIDGGGKGLSVDATVVLVDHDRGRKPLSAEDKALRRDSRSGSLIETNNTVVVDLATFAEAYHPWNYIFHVRTEQGIRLNDVYLQMAEGKMIGANAIRQEQLVGVEGGLTLNQGLVGEDMAGEKGEGRRVSGVPVVCLGGTFDYLHPGHKLLLTAGALLLGVPSKDELSLPATSPRRREPCKYIIGITGDELLKNKKFAEYVQSWETRARNVIYFLSRLLQLSDKGWREATGPAAGENNINTAVAAGVHIDEKDGDFRAAFRDGTIIVQCVRIQDAFGPTITEEDIDVLVVSGETRSGGKAVNDKRAEQGWKTLEVFEVDVLNADEIPEDVGEDVKATEDFTSKISSTVIRQQKAAQATGKSEAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJG6</accession>
    <name>A0AAE0JJG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_487387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684072.1">
        <property type="nucleotide sequence ID" value="XM_062827700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJG6"/>
    <dbReference type="GeneID" id="87864854"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="233" mass="24121" checksum="8817A8CDE008A76A" modified="2024-05-29" version="1">MHDNRTHPLLQQLPLTVSPFVSLPSSATLPYTYKPMPSALPPSTSGVGINNPQHSEGGSDPTTSSSSNNKPKYIISPTSGHAAHPDDIIASCQALQAHVAKLQSDAGAELKALEERIKKRELAEKRRVAPGWLDSEARLLEPERKGGNSKGGNGGSLLDAQDGEGDEQQGGNGGKDGGIAGLTQRFGGHGFGLGPAGYGGQGNGGPSEMAVPDQGEELDRAFGMVGMGSKVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKI7</accession>
    <name>A0AAE0JKI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_456749</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684323.1">
        <property type="nucleotide sequence ID" value="XM_062826315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKI7"/>
    <dbReference type="SMR" id="A0AAE0JKI7"/>
    <dbReference type="GeneID" id="87863469"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3351028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="183" mass="21692" checksum="E754DD49CF345517" modified="2024-05-29" version="1">MVRKLKHAEQKLLRKTDFINYKSDNKHRDHDVARRYMIQKPEDYHKYNRMCGSLRQLAHRLSLLPPDNEVRRKHEELLLDKLYDMGILSSKSKLSQVEHQVTVSAFARRRLPVVMTRLRMAETVQAATKMIEQGHVRVGVEEVRDPAFLVTRSMEDFVTWSVGSKIKQNIMKYRDKLDDFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKN3</accession>
    <name>A0AAE0JKN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_109184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684461.1">
        <property type="nucleotide sequence ID" value="XM_062820546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKN3"/>
    <dbReference type="GeneID" id="87857700"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="791" mass="91071" checksum="A3055CC2F917BAA4" modified="2024-05-29" version="1">MLLKLPFETLTHILGHFALTLPKNSDDFPSYRSARNHAYEADDLAPLLQDRRTLRKLCLVHSRCHAVASLLLYQTVILEDAAALPFFLRTLLESPKAGEVVRVLAVIATFNTTKDEYDLYRCAYKGLWADIGRQVFEEAPRKIQRGEFDWRIRFSNYHCQPDNDATDIQVTRRKTRTMELVNTLKRDLFLWAGFATGRDRPPMNKLMQDFLYCMLRETPRVRRLLLQFPLDWGAPQCSFASFAKLYDDNASSTPDFCSSLTELILLSTSKRPANCWLQDVRQYPFRYFRSLDTLTAIGSTETFDPFHHEALKSIRHLHLLDTTVQLRTLCGMLLKLPQDLVSLIFKQRPSDPFKLPALDDLPTTKAPTLSEALLLKGSKLQELTLVFCYSNCFKNFIGQRQRLTSLPTLDRLEKLTIQKHLLFGNPRNFSREVNLASLLPPNLIKLNILDEWKMDIIERETWLSRYQRNDPDYSEMDLYQTDVFSESDMSHLVHILPDDIPNVFKASKGLELFSSYRNAVETMLLNLAADCHADQIGCHMQAVDEQQSRRKLASLRSVTYQVAPNKPLELFPEAEARVHEENWSHVSERPPVKDSMEKTISAIKSGSFLCWIPCRWTDSILLDYAFGSRYDDFGVSVRYIRDDGSIGSSAAEGSDDVNEDSEDSEDSEDSEDNEDNEDNEDNEDNEDNEDNEDNEDNEDNEDNEDNEDNEDNEDNENREAVDQPKPKLLYLWCAFRNIQREYFADITAAFALSGVQFDCFGDSRPWLLAIRDAAKVEVQELGIDVVVREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKX4</accession>
    <name>A0AAE0JKX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_537643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684864.1">
        <property type="nucleotide sequence ID" value="XM_062829077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKX4"/>
    <dbReference type="GeneID" id="87866231"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="345" mass="39701" checksum="717E8E87B8AF687B" modified="2024-05-29" version="1">MSSNISQWLKTSEISPVLLNLNLTHLTPILDCEAAGRLFFIYIKDSCEKEVCHNIEWAGDPDLSGIGFYATYILMTVLATLFSVIYACYFLHWAWEERPGQPHSIWSGLAASQTPPEWKPLNDSLRSFWIFSVFFAYGITIAGFTLDRLEGSDVMTYRHWFSYREAHLSLMLLLSLWPWYRKQSTYPRLTIIGLGILFIILAATKYGDSDFGVTWVYGEESLYESWDCAYVEDKTLDFNNAMYAAQFVLLIWIGRPILSLLEGWTSAKTIQKGLKSLRRCIPVLTASLAFVFMWIDLVIFVRSRSELNYNAGSSYQENKWTFGQIAAVTTLLPLLADFYRIWLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMU5</accession>
    <name>A0AAE0JMU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_421814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685441.1">
        <property type="nucleotide sequence ID" value="XM_062824367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMU5"/>
    <dbReference type="GeneID" id="87861521"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="189" mass="21010" checksum="491F34E857EFAAFD" modified="2024-05-29" version="1">MNAYLYQSSLSFHSMPEPPSSMSSRSPYYPYNQSTYHNRDLALQTYLALHSQHESLVQHLDELRPSSPSTSPTRCSAPHGRSSPLPRQRQRSRGGFGPASATASAFGSSSSLTSSLDDQTLAEVALEEAKLCDVNEGIKRTLTELLNCEATRGEGNRQFRSWVQGRLMEAERELRRGRRRRSAGSACSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMW4</accession>
    <name>A0AAE0JMW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_16284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685904.1">
        <property type="nucleotide sequence ID" value="XM_062821268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMW4"/>
    <dbReference type="GeneID" id="87858422"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3354526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="415" mass="46313" checksum="7B9ABE288259C380" modified="2024-05-29" version="1">MPPPPPNRREQATAAPSSTDKSETGAGAARKEDNIYIPSYISKQPFYVSGLDNEEGDSLLHQRARQQEEDKAAQAAALLARGKKAGPARTKWVKGACENCGAMGHKKKDCLERPRKFGAKATGKDIQADRIVRDVNLGYEAKRDVYSAYDPKQYMEVVEEYNMLEEARKALQGDKKSPDGEGEGAEDDKSGFKYDEESDMGRDRATTKQSMRIREDTAKYLLNLDSDSAKYNPKKRALVDAGAIADKSAALFAEESFLRASGEAAEFEKAQRYAWEAQERSGDTSLHLQANPTAGEILRKKESEEREAKRRKRAEELANQYGTQPVIPDALRETIKESETFVEYDEAGLIKGAPKKVGKSKYPEDVYINNHTSVWGSWWSDFRWGYACCHQFVKNSYCTGEAGIAASEKADAWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN31</accession>
    <name>A0AAE0JN31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_449098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686009.1">
        <property type="nucleotide sequence ID" value="XM_062825936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN31"/>
    <dbReference type="GeneID" id="87863090"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3354631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="595" mass="66208" checksum="7D7190D6F96E2409" modified="2024-05-29" version="1">MNNEQFRRLLLANSQKNNNNQNGSTSPPSSSTSKSPVPAAPAGNSTPRSTLALGSKARSSIPMTPRSVAGFNPRNEFARQLAERNQQSLSSSSQQQHPNKKIRTSAPKGSRLAEGYVDRAKQRQAQEEADERERKLKELEERYKKEEIDKEEYERLRVEIIGGGGDLETAHLVKGLDFKLLERVRRGEVDVFGEKMKDASESPEVEENQQQQQDAEENEERADGGGEDGDADDVLEQLESAEVKVKKKEKVQKKGEFATTTLLPAGAKKTRNQILAELKAARAAAKAKEESSLGSRFKKIGPKKKQAETRIERDDRGNEIMIIVDEDGNERRKVRRVDLSKTREEQEKEREVLAQGKILGMDVPEYYKKLEEEKKAAEAAEEDKEPNIFDDVESDYDPLAGLESGSDDESDKEDGEEVEDTQKKEKKSSSDMPPPPPKPEPAALAGPRNYFQDSKTGLTSQEEYKKPSLDDPSFRAALAKAKAISAAEKSEEERLAAEREARLRKKLLESSRDDEDLDMGFGSSRMEDDADLDESSKVKLSEWGEDEDDDGYEGGGKAGLGSSKGKRKRGGGKKGGDKNNFVDVMKVIERNKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN58</accession>
    <name>A0AAE0JN58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_414981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685606.1">
        <property type="nucleotide sequence ID" value="XM_062823958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN58"/>
    <dbReference type="GeneID" id="87861112"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000676">
        <property type="entry name" value="C2H2 transcription factor (Sfp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="583"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3354228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="707" mass="76523" checksum="680DE2BC9B7C7789" modified="2024-05-29" version="1">MKRSLKWFGSKTSPSNSPEPAEPSARAGGNNSYRASPSSVSAAPRNPSPSDSTTGSPSSLLHPSSPSPSPTPQPPTPRDSVFPRSDFSLPAASKPIDIAVPHCRSTASISPVDRNPVTFPTHDLDDLDIDWDQGPCLADLGFDPDVDMTAGQHFDSALSRSRQESFLGTGAKPISMANPNRDHANRIRRESMAGSLRAGSLMAGSLMGNGMSWGGISVGSFIREDMMMTGTSPYLTHQSPSFHSSSYIPKLEANFMRDFTCCDRTWPTLHDLLQHYEENHHATAAPNTSNQNLNTFGTNQGNARGTASRATPTPVVGRAQPGAQAMNGYQGQRHLSVSGAGMGLGGIGQMMRQQQVAPAVQKMTSMSHMNDDMDTVGEMELDETVGPMEMDDNQRTIQQTRQLFGQQQRPQLHLNSSGLPHQALRTSQPPTPAAVSFGFQNNPTVSSVNTPTLTTQGGLPQRGQFGQEDDNGDDMSGMPMKMNLGGMNLNGGQLGGLAGNLAFGALGTIDDPAKRLYSPGGTTQMTSQQRAFDAQMQMQQQLQQHLASMNLDLNQLAPGTDPALLLQQMTALMMPPTEEHKPFRCPVIGCEKAYKNQNGLKYHKTHGHSTQQLHENGDGTFSIVNPETSTPYPGTLGMEKEKPFKCDVCGKRYKNLNGLKYHKQHSPMCDPEMRAQHQNLISTMMSNPAALIAFQQNLPNINEDVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNG6</accession>
    <name>A0AAE0JNG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_562695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685963.1">
        <property type="nucleotide sequence ID" value="XM_062830209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNG6"/>
    <dbReference type="GeneID" id="87867363"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="778"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="819"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="944" mass="105064" checksum="229C15396034A0C4" modified="2024-05-29" version="1">MDQEMKQAEPSPSPAPMAMASMPAASPQPQQEVVEMNQDQDSPQTPMQLDLSSPVPNNNSQQQQQQQQQQQQQQQQQQQQQQLHPQVNQINGQQLSGQIPGQLPLPGQLPSQVNSPVSVGTPGQVPGLALPAPVIKRRAPIACRRCRRMRSKCLHDKAQPPCQACRDAGLGPADCTFPVRGQPDQDREYRHPRIRADKSTKRDPAKVRREILDAPVRSPVPAMPRPIKGYDEWDLLPPLPEIVEAVHKFTAHYFQLGFIHKQHFPERLRTNHRSISVFFLLSILSISARLTPTLVDRFGGAVKAAEVFMERASEVACRELYRDPDLERCQAFYLLSIAQQGSSLKQQSSINMAIAMRMATLMGLHREETYRLPENPSEELIMRAESARRTLWMLHSQDNLHSGPRCPVSLSASDITALLPCNEKDFATGQIPKSRAALQDTPPALENPSLVTDEGRSLFATLIQAHYFWGAISRRVLSNDKVTDPWEPESEYAIMVNRLAEWERGLPNDHRWSSFLLKGYKQEGQDLAYLGVTMITRLCNIVLRKAYLTDILSDDKSQPERTAFWTEMSRQLFSNVRDLYEQIDTQYNERSPEEGPGAQMAAFCVYSCGFLACYLCKYPNLCPEPAITREGPLMVARVLSILAESRNIWPLATRWYEHLERFYTAQSGVIVGNEGTMADSVSYHHSLQKAPRSRTQQADFNLLLSQRDEIPHVLQMPTVQQQQAQAQAHMALAQAQAQAQAQAQAQQAQQAQVQAQQPSQQHLAFTAQMQAQQAQQVQQALSEKQESVPQGSPEQAIISPAQPSVPTPAMFIDPSLRVPTSSQPQEQTPAPTAPQQQDLASPSQQGQQPQPVVAGVAGRQSTDGLGLLIEAFDTQQAGGVPPTTTAGQGQVPYDPQAPPQQYYPQPGTLGVNDGYENELGYYMSDQGQPGAMQSWVGGTNMYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNS7</accession>
    <name>A0AAE0JNS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_22232</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686096.1">
        <property type="nucleotide sequence ID" value="XM_062822067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859221"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="18">
        <location>
            <begin position="243"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1588"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1588"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1609"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1707"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1722"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1751"/>
            <end position="1761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3354718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1761" mass="193866" checksum="17233430FE668BD3" modified="2024-05-29" version="1">MANLYFAHSSAPLRTIKEIQFGLLSPEEIKSMSVAHIVYPETMDETRTKPRDGGLNDPLLGSVDRQFKCKTCGENMSECPGHFGHIELARPVYHPGFIKRVKKILEIVCHNCSKVLADRNDKEFAAAMKIRDPKVRFNRVWAVCKKKRRCDNEVIKKSDDDEFNPLADAKGELPGHGGCGNDHPTVRQQALTLYAQFDTKDEEGVKSKEKKIITPEMALNILHNMSESDMIDIGVNISQARPEWMIITVLPVPPPPVRPSISMDGTGTGLRNEDDLTYKLGDIIRANGNVRQAIQEGSPAHIINDFENLLQYHVATYMDNDIAGQPQALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVITGDANISLDEVGVPRSIARTLTYPETVTPYNIGKLTQYVRNGPNEHPGAKYVIRSDGSRVDLRHQRRTGPLQLEYGWKVERHLIDGDYIIFNRQPSLHKESMMGHRVKVMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQTEETRAEVKELCMVPLNIVSPQRNGPLMGIVQDTLAGAYKLCRRDVFLTKEEVMNIMLWVPEWDGIIPVPAILKPRPRWTGKQIISMVIPKIINLKNLDEEDGECPLKDKGILIQQGEVIFGLMTKKIVGAASGGIIHLCYNELGPSGAMDFLNGCQRVVNYWLLHNGHSIGIGDTIPDAATIAKVQTHIDDAKTEVKQLTDMATNNELEPLPGMNIRETFENKVSKALNTARDKAGTTTESSLKDINNAVTMALSGSKGSSINISQMTALVGQQIVEGKRIPFGFKYRTLPHFTKDDYSPEARGFVENSYLRGLTPSEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDSAAQYDGTVRNSLGDIIQFVYGEDGLDGIAIENQSVDHFTISNKAFEKRFRLDVMDEEVSSSELEALEYGKEIASDPTVQELLDQEYEQLSVDRHMLREIQRRKGNNDTKMQLPLNIIRIIDTAKKLFKVDETARSDLAPKDVVPAVKALLDRMIVVRGNDPISREADYNATILFKAQLRSRLAFKRLAVQDRINKLAFNHILGELENRWSRSMVSPGEMVGVLAAQSIGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEILNVASNIKTPSMMVYLDSKAATQEEAKKMRSAVEHTSLRSVTAVTEIYYDPDITSTNIPEDYDLVESYFLIPDQSGDEPDPIENQSRWLLRITLDRQKMLDKGLRVEDVAHRIKEVYKKDVAVVFSDNNAEEMVIRIRVIKADDDKDEDGNKIIEDDVMLKRLEKHLLDGCTLRGVEGIERAFLNKGVKLIEAKDGSMKHSKVDDDCQEWYLDTQGTSLREVLTVEGVDTKRTTTNDLWQVVDVFGIEGARAALMHELTAVLAFDGSYVNHRHLALLCDVMTYRGSIAAVTRHGINRADTGALMRCSFEETVEILLEAAAVGELDDCRGISENVMLGQMAPMGTGAFDVLLDPKMLETVISDNSRMGLMPGMTVKGSQLDGAATPYDTGSPMADSGFLGSYSPTMGNFSPIQGAGSDSPTNNGFGTDYGGVGGYGSGTSYSSATSPRATSPFTPTSPFSYGGYSPSSPAAGYSPSSPLLDSSGRFASSPQFSPSSPSFSPTSPMLRPGSPTSPSYSPTSPSYSPASPAAARYSPTSPAQQFSPTSPSYSPTSPSYSPASPAFQATSPSYSPASPTWSPTSPDAYSPTSPSFQRSPGQQLSPTSPTGYSPTSPQYSPRTPGRNNSGGNGDQYSPTSPSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP65</accession>
    <name>A0AAE0JP65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenosine deaminase/editase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_27708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686258.1">
        <property type="nucleotide sequence ID" value="XM_062822829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP65"/>
    <dbReference type="GeneID" id="87859983"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="453" mass="49124" checksum="73F2D44732591480" modified="2024-05-29" version="1">MIDADVIASAVLEEFNKLPAKRKPSVRDNGLHEWVPMAGIVAKGPSGLKCVALATGMKCLPASKLPQANGVAIHDWHAEILTIRAFNRFVLEECKRLALQGDGVSQSEFIYRRTTAQHKDNEQQGTTNVWQGQPYAWREDVSLHMYCSEAPCGDASMELIMAAQDDTSPWEIPSPTPGDLPTQTPALASTDDTPLPGRAYFSQLGIVRRKPSRGDAPPSLSKSCSDKLALKQVTSLLSSLTSTLVSPANAYLSTVVLPESQYSVAACSRCFFSSVADEGRMAPLLDTSVSAKLAGAGYTFREFRVETTRMEFAFSRRAILPSSSTSASTEPTDTKTKKLIASNLATSWTLNGPRDGEGLVGGVLQGRKQFDPRGASLVSRRKMWALAREVCSAMELEDDGEIKQALGSTDLAYDEIKDGSSLLAGRRRAKEEAKRVALKGWVRNTGDGSFKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP84</accession>
    <name>A0AAE0JP84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_37961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686530.1">
        <property type="nucleotide sequence ID" value="XM_062823699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP84"/>
    <dbReference type="GeneID" id="87860853"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="708" mass="78477" checksum="C130549587D7547E" modified="2024-05-29" version="1">MGDGQDQMRAATATPQAPSLESFPNEIKLHILSCKSKLAPTLSHFSGFSGLPSWGNPQRPSILEAPHITNLQLVSRAFRDLARDNSFWRSRCLQESSFLESLERRRAFGRLATQGLGGTFQIQHDESAMGTIWQNAYPSPDSSSTNTPGSGSWATPTTPTILKSFRASSKKEQMRIMANWDPCFPTERVSWYEEYIQRHAPVAINWLPLPHAHGAKSEYVEARGVALYRPDNPRMEQGFEGNTRPASDETLLAVSPLDDGSVCIWDVNGTRGRKGAILAKSAPGLLLINGPGADNSKRSQRVDSGVTECVSVDSSLHRAFFAVQNHIIEVDLQRLSVVDYGSFPWSITTLSAASPTVPLTVGTNLALHLHDYRSRQRFRSAPEDDQVDFKLTGAQAMYERGIRNIFSDEPVGSWTSLAQPGPLSILHLQQPGQQAELSDDIYVAGRFSHILHYDRRNLSRIRGSINSKARLCSMTSLPFPFSKRDSELRRKGELTLQEVEGSKSLHGGRTLIAGGDYNMKGSLEIYGLAPPDSGKTLMGDLDDFAYQNRQSASGSKVLSVANHGTRIVFSDGSGYIKWFERDCFTEVRRCRIGHSEQAQGPSIFASMPGSSDIARKLLPTRVGEAKQKINDNDLLFWTGERLGLLNFSARPGFTAEQFEEQVEAVDDETRAKEREERDYTETMRRALQRHADDVAFTRHLGLGNGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPH7</accession>
    <name>A0AAE0JPH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_418039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686032.1">
        <property type="nucleotide sequence ID" value="XM_062824121.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861275"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="652"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1576"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1580"/>
            <end position="1604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1694" mass="190191" checksum="B5114E3716AA00C6" modified="2024-05-29" version="1">MTPWKLPSTAGRSVGILGAGVLGRRIGACWASAGYKVHIRDPDPQQTNAALQYITNELWRYKPIVDPNTISVHGFQDMKPAVEDSWLVIECVPEILDMKIDVFAELEGLTQPDAILASNSSSYKSREMTAKVKPETAQRMLNTHYMVPPAIRIVELMTSGSTRPEIFPFLLQHFEASGMMPVIAHKESTGFILNRVWAAIKRECLMVLAEGVASPEELDAVWTEMFIKAGSPPCILMDSVGLDTVSLIEKHYIQERGLQDRGVLPFLQKYIDEGRLGAKSSKGGLYPPGYTVKTANQEQMSDDNLHAPSLYFLDIGWNNDPDNVEFYRKGRILVGSADGRSPLKVIVDHLPMPDGIALSQKAGKILWTNMGTPGQNDGSIMSCNLDGTGVRVIIPPGAVHTPKQLSVDQDNEMLYFSDREGMRVFRCGVDGSNLQTLVRAGDWRKGIDDPTSWCVGITVSAREGKFYWTQKGPPKGSKGRIYRASIKMPEGCDASNRPDIEVVFDHLPEPIDLEMDEDGSALYWTDRGELPNGNSLNRATLNPDGSFSNHQVIARNLHEAIGLAIDKTTRHIYATDLGGAVYRFNMDGSGKQKFYEDQGAFTGIALLEQVDPSSSFFAIEVPGEAAPLNLVELARTLEYAALSTDHAQRQSAGQQLQSWESRPDYYVSLQTVFLDKSINNSIRFLAVILLKNGIDKYWRHTAKHAIQPAEKQFIRSRLLQGSVGEEDKNLALHNALVIAKIVRIDYPNDWPDVMPTIINVTRSARTESAVALSGALQVLLRVVKELATARLRRSQTALQAVTPELVQLLGEIYTERTAAWQQFFARGGSGDEDEADYYMQNSLTALKILRRLVTVGYEHPHTDPMVQGFWSLSQSQFDQFLTGISSESHIPAPFQDSVGKHLIQFTKLHIDMCDSHPASFPLLPNSIPLVKAYWNLVKQFSNEFEKSGGIRQTGSENHDGSAKHEGPLSEKLALKGLLLLRSCVSIAHRPMQTFKYKSPEVKNQEKEAMELVKDQLLTNNFLLDIVQVTISRLFIFRQSDLEAWEEDPEEWEAAERNEGQAYEWAVRPCAERLLIDLLTHYKELGQPLLTYCEFATKVDMDIVTKEAAYCALGCAAAVIHEAFDFDRFLKTTLVKDAQIQDSMSKLLRRRIAILLNQWISIRIAEESRPAVYEIFRHLMNPDDPHNDQVVRITAAREFKGIVDDFGFQGEQFLPFAPDVFNQLMGLLQEVASDETKLTVLDTIRAIVQRMETHISQFGDAIMLTLPKLWESAEKEEYMIKQSILAIMSALVDSMRGDSQRYQPAIIPLLREAMEPESALHLHLIEESVALWKSVTTQSYPPLHPDLVQMVELALPLLEYDSEVANQCLEVVKNYILLAPREILDDRLRRPTLAALVKTLDARSREQSQTGAKSIELVLRIAEDIGGVQGLQVVVQDMLEIGLLNTIFEGLHSTWEASTTHGPNKKVSQINTIKQTDYFMLLARIALGDPTVFLTMLAGIATTAGSTVEQVWEWLGTLWFNNFDCMAEVERQKLSLLALTRLWELPDPMVQEKIVLARLQDFLAMWTSVVTELAASEDDQQSLTEQQQDFRQSINSASAKEQQQQPGGGSTNPRDYLVWDPNSLPSYEWDTPLDVTERQFALKDPVHRVEAYEFTRERLQGLVQRMGGEQQFEAEWAVNVDKEVLEGFRRLGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPV4</accession>
    <name>A0AAE0JPV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_42465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686666.1">
        <property type="nucleotide sequence ID" value="XM_062824522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPV4"/>
    <dbReference type="GeneID" id="87861676"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="295" mass="33382" checksum="89D47EE5A48D20CE" modified="2024-05-29" version="1">MSTDQHQHTLRFIHCSILQTSFADLVAAVRIVKYIQSLCPFLPRGTTARDYDFTYHLKMSRNVGVIDSDSIEEVFKVRLVGFLSSSSWKISEGAQTHWFRSTHQKPSQPTATERRKCLGTRRFGVKFQITHTSVTTGILAHVSRYEKHVLSPSTVLIVATGLSDPHSLPSIHSSITKCRVLINPRNHFPMSQTRLVDSDPCFRSPMSLFEDDFLHHHVFQPSTRGNSSSSLRRGIACALIMTADLMRHLKGLKSPKWNGNLPQTTTPTREPYRSTRISFITAMTTKSYPSQVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ52</accession>
    <name>A0AAE0JQ52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A4 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_47313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686798.1">
        <property type="nucleotide sequence ID" value="XM_062827182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ52"/>
    <dbReference type="GeneID" id="87864336"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042104608" evidence="2">
        <location>
            <begin position="25"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="290" mass="31263" checksum="543CE92C6905DD4C" modified="2024-05-29" version="1">MKMPPSSLLRTLFLVSAVAGSAIAELTFVATARQGDREIPSSELEFVRTAPRRHQRNFHGEPSQTETETVELGKRDITAYGPSWCGASQQLASPEQLSSIYGVFSVPNLKLRAGLSAPQNAAAWVGVDGGSCNRALLQAGVTTLIASNGQQITEAWWEWWPSAAYSIPSIPTAPGDWMAVNITITSPTSAVIKIVNTQRGYTMSINATTGATLCRTDAAWIVEDYYDGAGGMNMASFNDVWFEYTAATTVGGTKLGVDGGIFWNIQNSTGQLKCTSQKYDNSNFVIRSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ90</accession>
    <name>A0AAE0JQ90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_536385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687165.1">
        <property type="nucleotide sequence ID" value="XM_062829044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ90"/>
    <dbReference type="GeneID" id="87866198"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="353" mass="39560" checksum="EC53109C20B9047F" modified="2024-05-29" version="1">MLSSNPCDLLAVIPGGPPILGLPPKPCQRKATSPKEEDKKRLLPKGTKGLAHSRFAKKPSNKGNGKAQYTKKIGPTPDEDAAVKAFFAESPKKYKEQKDNGESSYQAADHDTPRAKRGTSLRAMGAWTDEEVQDWFRGGEKEYEAMKDGVHTHVSRIHHPPEVMFYIYRDVWTVNEEHYWVNENFPPLFRCRDYFKAQQEALCKLQLLSREIRNEVIAEYFPRAQYNLWYDWPPPNTNVKYFQKGNSKQAYSKKFRPSAEEDAAIKAFFAESPEIDKQKAKKEEEDPKPLYPKATKGLANSRFAKDAIEKDTTAAQVASPSVAASNTKAELAATNTTAAQASTPVTSTTPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ96</accession>
    <name>A0AAE0JQ96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_450588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686437.1">
        <property type="nucleotide sequence ID" value="XM_062826015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ96"/>
    <dbReference type="GeneID" id="87863169"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12728" checksum="49D30A5AC888C5B1" modified="2024-05-29" version="1">MATRRIISQEKTLLEKDDRIGFSPSASEKSNITPAVPASVIIKLLAFTFAMIVIPISSYFLTVDRLFKGNSTYAGATAAIMANVVLIGYIIVAMAEDQSDQENEKKEGGGKAEGKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQJ9</accession>
    <name>A0AAE0JQJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histidine kinase group protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_54817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687043.1">
        <property type="nucleotide sequence ID" value="XM_062829561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87866715"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="858"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="931"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1352"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1406"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1520" mass="167438" checksum="ED26FEA3BCDCA102" modified="2024-05-29" version="1">MTLQDTTKSRTSAEDVINLGADLPKASAFGITTTVSGDPPQSLTNLPPASGRSVPVTHLNHFQAKDWTKTHHLSGLTAGTQDGRLPGVWAPNSGRYGPIANKAPHEHLGALSIPPISGHFGHPQPITAEDKQELRPLDIPSKKTRLVAPGSVHLPALPHTPDELVSHSPGVSSPLFFSHRAKQQHPTPRMHSFFANGIAASIMSSVQETQDGVTTLRLPKGHVTTTTAQGSNRSSSTPGSWTSSESLDATMRSPDGRPLAIVAPALQAIPATELLDQDPRPVFIVDLGNPLNASSGLLHIVYANPSLKASTSVLELLNGDTADAEADSFDFAHFKLWVINSEANTESIDLALTCITFGGINWTCSTLRKRFRVVTGHSNIVSETPTTPSPVAQMPPVLSRRARGSVSARELSPERGDAVDYFGPMEEVGSPRPRSYSEPRSPSRTIIDTSLAGLNELPMVLPMSQVYTTFDWTRIPVDDPNLGPHHRFARSVDWASTPLGPVEEWPADLRIMSNMIMGSPHPAALYWGEEFVAIYNEAYIALAGKKHPQLMGAKYKEAWPEIWDEVGPIFDAAWNDGSATMRHDDGLFIIRHGFLEETFFNWAVIPLVGGDGTVVALYNPAFDNTRRKINERRMLTLREVGVQTSEARDVKGFWGLLVQGLEYNGLDVPFALIYSVAEDSESEAASINSGSVTNPPQIILEGSVGVPKGHPTAIQSIDLRTSDEGFAPYMRDSMAHPTNPIILSESDGSLPHELIEGFDWRGFGDPCRTIVVFPVHPTTAGDMVVGFIVLGVNPRRQYDEDYKLFVNLLSRQLATSMASVVLFEEEIKRGQRAARLAALDKQQLSMQLHLRTQEAVESEYRFARMAELGPVGLFIADSHGRINYCNEMWWRISGHERSASTLDAWMQSIRDEDREGVVNVWRHLVEEKVPVTYEFRFNGTRKIVDGHTVDTWALMSAYPERDETGELKSIFGCITDISQQKWAEDFQKRRRDEAVELKRQQENFIDITSHEMRNPLSAILQCADEIASGLNKFRQEDPAFRGPDTLETLVDSCLEAANTISLCASHQKRIVDDILTLSKLDSQLLLVTPVDVQPVQVVEEVLKMFEAELNSNDIKGHFQIEQSYRNLEIDWVKLDPSRLKQVLINLMTNAIKFTQGRPTRAITINLGASKDVSSAGLSYFPPRHPDQEDLTDDAEWATGEKINLHLAVSDTGPGLDENEKKILFQRFSQTSPRTHVQYGGSGLGLFICRILTELQGGQIGVYSEKGEGSTFAFYVKSRKAENPQPVPTVVDNSMSIQPLQMRVNPLTQAQISHRSSGSAAFSLLGHGRSHPPPTRTQSAPALTDVTQTRSLDVLIVEDNLVNQRVLQRQLQLSGNNTFVANHGGEALVELRKSRFWNEEIAATDDAASALPRSNKKAASDGGTDGAPDGEENNKNISVILMDLEMPVMDGMSCTREIRRLENAGVITRHIPIIAVTAYARPEQVESARAAGVDDVISKPFRLPELIPKIEELVLKYDGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQZ6</accession>
    <name>A0AAE0JQZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_453984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687474.1">
        <property type="nucleotide sequence ID" value="XM_062826176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQZ6"/>
    <dbReference type="GeneID" id="87863330"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF11">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="17"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3356097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="402" mass="42100" checksum="8291EAA55C66ABA3" modified="2024-05-29" version="1">MATPRTTTALVIPELNGQFELQEVQLNDIQPEEVLVEIEASGICHTDLSCAIGLLPCRPGAVLGHEGAGKVLSVGTSVTHLSPGDSVLLSFSHCESCAPCLSGHPSYCHSFNVRNFSGCRPLPVLPDGSVDSSSLSPDGVDPTADPSFATFVTKDPGGGKPIFSQFFGQSSFARHTLVHKSTCVKVPPDTNLALFAPMGCGMQTGAGAVLNSLGVKPGSSIAVFGVGSVGMAAVMAAAYIAKAKTIIAVDLQESRLELAKKLGATHGVLAGTVAADLKGEVRRICPPVGVDYAVDCTGSVAAIRTMIEVLGTRGRAATVGAPGFGKEVKVDVMEHLTYGKEYVGSCEGDSLPREFIPFLIEQHAKGNFPMDQLVTFYDVKDYKQALEDSHKGKAIKAVLKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MK91</accession>
    <name>A0AAE0MK91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_479886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676954.1">
        <property type="nucleotide sequence ID" value="XM_062827551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MK91"/>
    <dbReference type="GeneID" id="87864705"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="54"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3334788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="332" mass="36498" checksum="5228551DBC12D024" modified="2024-05-29" version="1">MSQHFYIENRNVGNQAESEDWRIRGYNPLTPPDLLQHEIPQTAESKQTVINSRKEVVDIVNGTDEKERLLVVIGPCSIHDPKAALEYCDLLLKEKEKHKDELLIVMRSYLEKPRTTVGWKGLINDPDIDNSFQINKGLRLSRQLFVDLTSKGMPLASEMLDTISPQFLADMLSVGAVGARTTESQLHRELASGLSFPVGFKNGTDGTLGVAIDAIGAVRHPHHFLSVTKPGVVAIVGTVGNEDCFVILRGGTKGTNYDAKSIAEAKAALEKSGLRQRLMVDCSHGNSNKDHKNQPKVAAEIAQQLENGETGIMGVMIESNINEGKFPRHRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMG8</accession>
    <name>A0AAE0MMG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_477225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677373.1">
        <property type="nucleotide sequence ID" value="XM_062827415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMG8"/>
    <dbReference type="GeneID" id="87864569"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3337922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="505" mass="55314" checksum="6A5E92057F6A2CEC" modified="2024-05-29" version="1">MSDTTAVANGQTRPKYERIQSQPENPFAALIPDQQIAVIPSFTLESGVTLHNVPVAYTTRGTLNADGDNAMVICHALTGSADVSDWWGPLLGGPGRAFDVSRFFIVCFNSLGSPYGTASPVTAKDGDPTKGRYGPEFPLTTIRDDVRLHKLLLDDLGVRQVAAVIGGSLGGMFVLEWAYFGKDYVRCVVPIATSSRHSAWGISWGEAQRQSIYADPKYDDGYYSFEDPPSTGLGAARMSALLTYRSRNSFEARFGRNTPDPSRRQIIRERPTPSTPSEAHFHIHNDGHKVKRTNLSRSNSPVDATATAAAASNATQEAEVQSDPQFHGPQKTTTTATITSLTGGDVMPPQSTYFSAQSYLRYQGSKFVKRFDSNCYIAMTRKLDTHDVSRGRAASIAEALALIQQPTLVLGIESDGLFTFAEQEELAQHIPDCRLERIDSPEGHDAFLLQFEQVNRYILNFLREVLPDIMNKDVPEGSEAVESSVGQITKSSTFGEAEVEDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN64</accession>
    <name>A0AAE0MN64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_476969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677284.1">
        <property type="nucleotide sequence ID" value="XM_062827401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN64"/>
    <dbReference type="GeneID" id="87864555"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="277"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3337833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="530" mass="56509" checksum="4CE346A6F1837AF0" modified="2024-05-29" version="1">MSALFDTNPSQPPNHDSNAIELAQRSQQHASFAGQESDPETLRAAGGTPPPDDIDPASIALVEDVPPDGGYGWVVVGAVFLMNVNTWGINSAWGIFMELYIRENTFPEASHFEYALIGGLSVSLALILGPIISAIQRKIGTRYTMVLGSLMIFAGLFSASAASRVWHLFMSVGLCMGFGFGLLYIPAMGLLPPWFSRHRSLALGLATAGAGGGIAWNLITGKLLAVSGLKWTWRILALVSVAFNIICAFLCRERPISSSTGSSKRRSFNIRDFGRTQVLLILLWGFITEFGYVSLWYSLPSYATSIGLTPSQGSVVNAMLSLGVGVGRPLVGALSDRFGRINLALLCCSSCAILCLTLWILARSYAGLIIFAIAAGAGGGCFWATVNPILAETVSLAESSAIFGTICFALVIPTTFGEAIALQLVKGGDGVNKFIPSQIFVGCTFLGGTALLMLLRSWQICEIERKTGGAGSGQDWEGHRRSGEENRMEEDLEEGVMASGRSAGVAVLGELRSSAAGMWSPRKLFVARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNN6</accession>
    <name>A0AAE0MNN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_295630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678633.1">
        <property type="nucleotide sequence ID" value="XM_062823075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNN6"/>
    <dbReference type="GeneID" id="87860229"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="810" mass="88322" checksum="CD3F9CE1AEBD8A73" modified="2024-05-29" version="1">MAAVQYSAEYLLYLRQSPLCVKPPGLPPAEEWMGPPPETGRNSQAKTTNDRIKGGDSFLLNQENRRPALDRNGSRNTTNPEDIILGPPRTSFASATTLRNNRTSDADKGLKDNDRQDRTDRFNFRTRTNDSESTNDRFGNGRNSAFRRRGDDQDRDSEGWTPVKPRKSFGTEGAERFQGRMGAAGERFGGSRDTQTKDVSDRRNRAQDLRDKDGEDIDTPRRNGLSRGKTDSWFNKENTNSSDNNGASLSVRERIDRSKSWRDREPEDRQNDRYGDRAGGYGGGRYDRDRDQRVERDPEWLDEPVEHKSQGHTAEDFKKFMESMKSKHGGGPKAEEKAPAPLQTNLPEPSFEAERVLSAPALETGPDKFFAAYGGGLQVSTPTAEKEASKPTSGKGSRFMAFLAPQEGAKTEPSTPAATAPSSGQPNEGPQKNEAEKEAFNLLIQKLQKSGMGGPSGPSGQAANPMAQLFGSFSQPAHLADSQPKSQVASPEPFQQYGGERRDDPRFRAPPPNPLHDILSPRPMAPPTQPPPMTRPDQALHDIIAQRHAMPNHGNNRGAQNPMVNNQTEFLMRLMQNHKEVPEPPRQEQLLVRMPQPTKQVNIPDLSDREAEYQRERSAAQRQQQQIRGPAPPGFFNDQFHPSDVDNRPHQPPTQMPTQILQRPPPPGLDHHMLPFPLGAGGAGNPGSGVGGQPMGPPQRPMIPPPGLVNGPRNGPMPGMFPMNFPPPGGAFPPGPPPPDSLVGPPPPRGMQPPPGFFGGGPPPGFMGPPPPGMGGFQGPDGGPAGFGGAGGLPFPIDRRGMLPPGYRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNW9</accession>
    <name>A0AAE0MNW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_304543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678962.1">
        <property type="nucleotide sequence ID" value="XM_062823196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNW9"/>
    <dbReference type="GeneID" id="87860350"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="684" mass="71152" checksum="AA2429B5088975E6" modified="2024-05-29" version="1">MSFGPDYHLPGGYFDTGNNPSQTLSAGIFRPPASPADSNHNLGKSTGSLFSDISMSNGTSPIQTPEQANAKRKRLGLGVRGGTLNDHNMQVDGMNDGKAETTGMADAGQTRYNLAGQLNATPTGGTVTVNGRLEESMYSDLDYRRAAGSKRAHDDPDGPSPQVEGQVDPSTQQQHSANSSKWGFLGLQSIGQVMGKVWEFCKGGAFRGFQAGGGTGYEVNGSTVTPSVQATAVGQPWASEQQEHPIHFTMEADQDTSMPPQETVITPISPPVQEFVAPQEFSSPLPLPVSDYMPYAPEYHETSNPDSLTRPAVKRRQVSEAQDDLNRNWVVVDENGNGGSPSPSPVLPSFGAVPSGRATPGLRPPSSLRARTPGLSSSNAARRITAPSQRFTGGPSMLPRTRAPSRLSQHTVAPSVGAQELPSFGAPRSPPVRDTPTPSFSTPTTTAAPVSRIPLPASAGGGPGSGGARPSFGGLNAAVSNGRQSPAAFNGRQSPSYANPTPFAFSSPAYQSSSASRPSSRQSVGFGSGGGGGGGGGGGSSTTRRSLQAPIQLSSPAIPRPSSSSAAKVLKSPTNHRRGESSGAAGPSHGSSSRPGSSMRRSRGLSLHGAYIEDGLKASPRLDGEAKHLAKKKMAADRDADANIDAFNEKLLQMIRQGKEALGTKVEVLDDRGGGNVVWEEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNX5</accession>
    <name>A0AAE0MNX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine deaminase</fullName>
            <ecNumber evidence="5">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_310910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677480.1">
        <property type="nucleotide sequence ID" value="XM_062823297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNX5"/>
    <dbReference type="GeneID" id="87860451"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01303">
        <property type="entry name" value="GDEase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000021">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="13">
        <location>
            <begin position="86"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3338029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="497" mass="54261" checksum="40EBDCE8298A5101" modified="2024-05-29" version="1">MGSQEQTTLVTQNQLFYGTFIYPKTLTELEYLYNTAVAVDQNGTIVAIKRDCDLSQATSTLLPRLGWAPNSVTIHSSSDSHNQFFFPGFIDTHLHAPQYPNVGIFGKSTLLDWLETYTFPLEASLSDPAKARTVYNRVIRKTLSHGTTCAAYYATKDVTTTNLLADLCLRAGQRALVGRVCMDQLSPDYYRDASAADSVAATRESIAYIQSIDPTGAIVRPVITPRFAPSCSAPLMADLGKLAAETGLPVQTHISENEGEIDLVRELFPAKKIGAKGDTYTHVYDTFGLLTDKTILAHGVHLSEEEVEIIKARGSKVSHCPCSNSALASGAARVRWLLERGVEVGLGTDMSGGYSPSVLEAARQAALVSRHVAMGCASVEKGSKGSKANKDGIDRERAKLTVEEVLYLATKGGAELVGMKGRVGGFEVGMEWDVQLIGLGRDVADGEYEGEEKEEEGNVDVFGWESWPDRVAKWVYNGDDRNTRKVWVKGRLVHERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP58</accession>
    <name>A0AAE0MP58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_512149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677735.1">
        <property type="nucleotide sequence ID" value="XM_062828551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP58"/>
    <dbReference type="GeneID" id="87865705"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="687" mass="74687" checksum="1D77307887287F3D" modified="2024-05-29" version="1">MPSSVNTSHGGLATLVNGRSSSPTMSTTTTLSPPSPVMGGGGGGKHHHHPSIISPDAMADVKSKIKKLASELKQQQQKQQQRCRQQSSNNNNNTRPILPYLNTDSITTTKTTLSRPVLSPFSRAKSHQLQQHQQHIRHPSTPGPGPGPGPVIPIPGLEPTSRSLSDLHNERSYLLHNLQTQGERATRLYQRYAHLEAKKEALKKEASVSAAAASTSPSDENNNNNTTTGSTSAPPASVSSKKKKIKKDLSLLRSRIAESTQQEQLIMLRLGEIHVELVNRGRWVMTHQHQHQHQQQQHQQQQHQALIYSPMSAVVEGQGQGQGYFGHHHQWHQQQQNHGGGIPATPSSLGADSYSNSSPVGGDDYLYTPSSVLSPLSPSFVPSGGGVSFFEDIWTRPSSHQSQDHHSTTSPEETTHDHHHLAPAPEREQEQEQEQEQEQHHAAAEGEEEEEDDQTPKPKPKPSLFQDLNLPLDSPAVPLSAVTPKFTSTSSTVSTSTLPSLPSEHLATPITPSRIPWDEYPSDSEDDESFESFDGSSFTPIGVTNTNPLTCINPLINGSASGSGSGSGSGSGVMVSEPEEEEDEEEEEEEEEEEEEEEEEEEEAEGSEGSDDSASEPGDLLSEQQRRTASFSRGGEEGEGGDGWRRLSMPSLKNLWPAALAAIGVQGLGEEGEEEEEVPEMRLDTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPE3</accession>
    <name>A0AAE0MPE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_259317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679383.1">
        <property type="nucleotide sequence ID" value="XM_062822595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPE3"/>
    <dbReference type="GeneID" id="87859749"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="185" mass="19706" checksum="8FA643BF33231987" modified="2024-05-29" version="1">MSSSSLLLSPGPYHIISYGTLLGTTFFHSFVGGIISFQVLPRPQFSALQTKIFPVYFSIQTTIPVILALTYPGATSAFGSAGAAGIAGVLDPDNRWSVLAPIAAIFLTGLANLAVVGPATTKCMKERKHQETKDGKKSYDAPPHSQEMTALNKRFSQLHGISSLLNLGNFIAAVVYGFTLASRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ34</accession>
    <name>A0AAE0MQ34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4238 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_217053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680133.1">
        <property type="nucleotide sequence ID" value="XM_062822004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ34"/>
    <dbReference type="GeneID" id="87859158"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="87187" checksum="E0851442B02FC8AB" modified="2024-05-29" version="1">MSHPKPNVMAPAASNGQYQHFVPQFLLKNFAHRVPKAPKGPKGTPKPKYEKGMFPGDLVISSLDLTQDAAVFTEKPVSRILGQINMYDDFTKPNGEQRHVEKLLSKLEDQAARIFTKITKAYEANEGGVVLTRDERNLIRKFLFVMKYRGHRFHTRFFHERPEAYSENDRELLREYMEEHPQFKTPMQVWLHNIETLINLEMDPELNWIRELPKKMYYNDAMWFVTHVQSCYMALCVPSEAENEFILADNSYSVYEGPNKYARDIKSNKEEALGYVELHTFAPVSPKIMVVLRSWILPQPLEDQSPEVKEDRDFQRSLVMGPYGHVNGMLADLPVRKAENSYSEIVNGRLVFQEGYDGRRGKDDKFRFPFFPIESQHVNTINSIFLDNCLRCTSLVYNSKQAFARTLEWYLTAPPLEIGKIFTGEDKEDRLKTLKKLEAVSRSLGSEKAALWVMPTLPSTVQDHEKIRLRRLERHRESKNAVVNDERIQDPHGEAFLKSMMEQNALTWGLSEPAAPYMDNYFLLGGSYNTVLEDIDQVVKMNTLRIKIDSWSQGVDEAIRQRNRESLVSEYLRLPSPRLWLYIQAERDMIMEHEGIDLLSPQGDWLRMPENAIVRAKKLIRPDRLNTLMYIAFKIDTRFRQRAHLNIRTEFAPFIQGAGPILNCGIQQIEDLAKSTDLLSMAIVADVTLRNADPTLNSQFKPPERLELIVRSTCREMFATIMEPERIKHNLSRQVIEDLEKVLFTLVYPTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQE9</accession>
    <name>A0AAE0MQE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_444731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679714.1">
        <property type="nucleotide sequence ID" value="XM_062825697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQE9"/>
    <dbReference type="GeneID" id="87862851"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="115" mass="13111" checksum="42F14C78E51A67CE" modified="2024-05-29" version="1">MLNSGDRHHHHYTTLHYLELSRLRSVLPRTAQQQDRRSEQYPILVYLSAVTVTIFSIPITPEPESFITVTLACEDDGATSTSIKRIDQNHQGIYYTPQLAHRASIQKPQTSIPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRK8</accession>
    <name>A0AAE0MRK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_395293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681336.1">
        <property type="nucleotide sequence ID" value="XM_062823764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRK8"/>
    <dbReference type="GeneID" id="87860918"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041768484" description="Protein kish" evidence="9">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3344723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="65" mass="7294" checksum="CB202B693083091A" modified="2024-05-29" version="1" fragment="single">TALFNFQSLLLVIILLVCTSTHVHQIFPAILDRNKDGLMGIFWKCARIGERLSPYVSICCVLMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRN0</accession>
    <name>A0AAE0MRN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_429455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680345.1">
        <property type="nucleotide sequence ID" value="XM_062824826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRN0"/>
    <dbReference type="GeneID" id="87861980"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04486">
        <property type="entry name" value="YhcR_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041998772" evidence="2">
        <location>
            <begin position="20"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="301"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="623" mass="65957" checksum="2DD86ADCC94E6241" modified="2024-05-29" version="1">MKGALCWAVAGLQPLLSAALTIAEINGNKFISSYNGKTVSDVTGLVTAKSSAGIYIRSTTPDDDEATSESIYVFSSTIGKTVNVGDIITLGSAKVSEYRSSNTYMHLTELTNPTGITVVSSNNTVTPLVIGKDTLSPPTEQFTSLDGGDIYSVPNAQQNISAVNPVLKPAEYGLDFWESLTGELVTVKAPTALKIPSSYRDTWVIGDWKVTGKNDAGSLTMSAKDSNPETIIIGAPLDSTKNPTTTKLGDALEDITGVVTNTFGFYTILPLTALKIKSPSPLSPPPTTLVSSKSCKGLTVGTYNVENLAPTSAHMPKVASQIVTYLKSPDLLFIQEVQDDDGATDDGVVSANKTLTTLISAIKSAGGPQYDYVTISPLNDEDGGQPGGNIRTAYLYNPSMLSLKNGATAGSSTDANEVIVDAETGQPSLKFNPGRVDPSNAAWEATRKPLAAEWIAKDGKKSFFTVNVHMSSKGGGSSVHGDVRPPVNGGVEKRTEQAEITASFISKILKADPAARVIAAGDFNEFAFVKPLTTFASVSGLKELDEALNTPVENRYTYSYDMNAQALDHMYISPVLASSKSKFQHIHVSSWVTASAVVSDHDPSVALFDVCGCADSQKRVHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRT0</accession>
    <name>A0AAE0MRT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_466212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681917.1">
        <property type="nucleotide sequence ID" value="XM_062826844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRT0"/>
    <dbReference type="GeneID" id="87863998"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042206382" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="81" mass="8812" checksum="612E1FAF401D4232" modified="2024-05-29" version="1">MASRGASFVHASVHDYIALLALLLKVSGPTGTVKIACSMPHCAQSQLPEARLQSMEVSHELCLLWGHGEWYFPLACSKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS13</accession>
    <name>A0AAE0MS13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_234451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680735.1">
        <property type="nucleotide sequence ID" value="XM_062822235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS13"/>
    <dbReference type="GeneID" id="87859389"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000214">
        <property type="entry name" value="Toxin biosynthesis protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="57"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="412" mass="46635" checksum="41FFA6D55D9820E7" modified="2024-05-29" version="1">MASSFIIKEHKVEGQHIRDYAHATANSQEEILYLSVKQYIPKSNPNPQPGDLTIIGAHANGFVKELYEPLWEDLAKALSARGIRIRSIFIADAAWQGQSGLINESSLGNDPSWYDHARDLLCVVNALRREMPRPLVGIGHSFGGNTIVSLSLLHPRLFSSLVLLDPVISKFTKRGPAYGFMPMKQSAYRRDVWPSRKAAAEGFRKNQFYQTWDPRCLEVLIDHGLRRVSPEKEEVTLVTSKHQECFTYYRPKKQDQPVPDLPPDHAVDSNFQFYRAEGIMTTYFLPHLRPGVLWVFGSTSDVCPPETREEKLELTGTGWNGSGGAKAGRVEVRTVEGYGHLVPMEATTRCAEEAAEFIAKDLEKVWRKEDEEFRKVWKGREGTEKRVLSKEFLELMGPPPGRKKTGKEEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSU0</accession>
    <name>A0AAE0MSU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_507859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682952.1">
        <property type="nucleotide sequence ID" value="XM_062828177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSU0"/>
    <dbReference type="GeneID" id="87865331"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="73303" checksum="85A7963811DA94C0" modified="2024-05-29" version="1">MQCHGADEWVSSGRANMAELRGDIETYRRALGLVLDVVNYHHSPFNSDTSNLDTSKSQITTEVDRLRSHTALTGLDNRNTWLEPYMNAVINCLEITGADSPVIKGDGPPKDLSLNLESQQPATPPSAPTQQESSPKYVINSVYETAGPWYPPAGAIALPFYNGGENPASVASSPRREPQQVSPRLRNSPLDPSRHAPTPESPTSIQFSQRAQSPPSSQQSWDRGSPSARSEPFEASYVPHQDLRADRWSEPQPIQNPEHYNHIVSKYLIPGYYTRFSLVTTVPVPKPTMASKHHSSQSYPSMVSHQVSGSRITTHFGLDLEIYNFTKGGSGKKVQVIDEAHRWAASHKLDNSYAPLVIYRPGADRIDRYFLSRNPGAKKPFWEDASSCIDLTKADLPFLPKWPELAFSNDSPFLIAAAGPRPGDPPRDINSNILLVAWHLTPVQEAKLQARSPVNSVHSHIQESGDPKRHKPYRFCAPAYTQLQTALPSVLVSHGSVTVSIWIPASHVNIPLPGGKFRQTRVPTPERFVLVWDMPTNTTRLIPIPNVQACVSPDCRLVAYCDPEIQKFVILDVTTAEMVWKWPDAAAVSGFASFGQFEAIKKITVFEFSPDGKWLIVGDASGALGVYEVREAGTRFELLDQSSLKGVSELGGGNSLPRGNVAELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSX1</accession>
    <name>A0AAE0MSX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase/Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_462432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683193.1">
        <property type="nucleotide sequence ID" value="XM_062826642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSX1"/>
    <dbReference type="GeneID" id="87863796"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="441" mass="47649" checksum="C2177235C27BE017" modified="2024-05-29" version="1">MGKTEIRTVCKVDFDKPASEQPQLHNRWHPDIPFAGTIADGETVKIECVDWTGGQIGNNDSADDMRNVDLTKIHYLSGPFEVEGAQPGDLLLVEIMDVQPFQDRPWGFTGIFDKSNGGGFLDEIYPSAAKAIWDFEGIYATSRHIPGVKFAGLIHPGIIGCAPSAEVLATWNKREGELVAANKLADREVAHLPQPINVHAGAASNEIAEKVGQEGARTVPGRPEHGGNCDIKNLSRGSKVYLPVHVPGAKFSVGDLHFSQGDGEISFCGAIEMAGVITINFKVIKNGVEGMGLKSPIYIPGPVEPSFGPGRYIYFEGFSVDEHGKQHYMDVTVAYRQTVLRCIEYLRRFGYSDYQIYLLLSCAPVQGHVAGIVDVPNACTTLGLPMDIFDFDISPAAALKAGETKRDLGSCAFETGVTEGKVTKGGKNSQISFGGGLTYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT65</accession>
    <name>A0AAE0MT65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_441131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682594.1">
        <property type="nucleotide sequence ID" value="XM_062825505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT65"/>
    <dbReference type="GeneID" id="87862659"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="166" mass="18451" checksum="8D13C4A212EB5A85" modified="2024-05-29" version="1">MESTDQVIHLPESPSLETGIDQRHDSSSTHISVTEVIHYTSSGSTTHSTGPTTPHAAATTSSGTVLESRRQEAYKINSSNQVNLVRAQATALGHVHVPPLVSSYHVQYRVKVHNRPYVAQRICSLPKCFRMQSKLICRKNETDMKTHKLNRLREARRAAIIAVMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTR2</accession>
    <name>A0AAE0MTR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_424469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683224.1">
        <property type="nucleotide sequence ID" value="XM_062824513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTR2"/>
    <dbReference type="GeneID" id="87861667"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="288"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3348142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="581" mass="64757" checksum="A7F1E711A2AE27DF" modified="2024-05-29" version="1">MFVPRRRPLASTRCEDLNLISRMTLQYQTDYQVASVTKWFAEDSGGEAKREDSRKKAANQRDVVLVKATVNPSQQCARTMTPRSSHGLGNDSITSNLNDNIYTRDALGGIGSHPGGFNTGILPVIPSDGQLPDKAPSSNAATGASAAGVRALASQVLTFYFRAPAKAFFRTRVDYLAYARALQEQQSMLLLSQLPVPSQVLTTAARAGAPTAVSQIWDWVRMRARATTPGVIASAVKHYGWRVVPDQVLPPLIANVTVGAVLYTSYLHILGHLHPESRLASKRVYPPPSPLETFTAGFLAGTLQSVIAAPLDAVQARYDIGHYTGTSTTPMNGNPNAVRPKSMWVFSVEKIKEIGVRGIFAGWTLSFLKDSLGSAIFFSTFEYLKAQGYYNFVSWYYGSLNEENIILLSEKRPSSESGKEDNDDPRMPAIIRPHYAIEPAFLLLAGMGASILQQFMLHPLTIIQAEHWERLEKIDAQARKLKEIDKERFLPPAEERARFRWRMMKTYYSAYQETWASCAADAKGAGLNMRNWLYRGFWWNTIRQVPSTSAGLIIFELVRRKYGFGGEQVRINRDGYDILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTY2</accession>
    <name>A0AAE0MTY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="13" type="ORF">B0H65DRAFT_456191</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTY2"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5041755340" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041755339" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="359"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="2"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="2"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="358"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3350872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="403" mass="44971" checksum="AF57E89C2CE6AEE9" modified="2024-05-29" version="1">MSTLPLKAMSRLWGKFNELTIPYYLRAPGFRLYAYFFGVNLDEIEEQDLHKFPNLAAFFYRTLKPGVRPVDPNHNALVAPSDGRILQFGRIEGGDIEQVKGMTYTIDALLGQNSPTPSISGTTLLDESTKAKSVNGDFEGDDELVKKDEEFARVNGISYTLPDLLSGSKKHDKLFKPKDESVTPSKTSETEVSAELALGEKPWYDVLSGGERHTLYYAVIYLAPGDYHRFHSPTEWVVERRRHFAGELFSVSPYLQRTLPGLFTLNERVVLIGRWRWGFFSYVPVGATNVGSIKINFDRELRTNSLTTDTAADRAAELAAAKGEPYLGYAEATYEAASPVLKGHALRRGEEMGGFQLGSTVVLVFEAPVAEYDESGKVIKGWTWDVEKGQKIKMGQPIGHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUX0</accession>
    <name>A0AAE0MUX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_87244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683720.1">
        <property type="nucleotide sequence ID" value="XM_062831516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUX0"/>
    <dbReference type="GeneID" id="87868670"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="105" mass="11177" checksum="0CECAB7337B5C9A3" modified="2024-05-29" version="1">MIITDGNGGVSGATVSTDDAISINIKFDDPNTNSSSERGYARNNVDTVDVKGEEGSGVKSDSDEHEGKDAGEKREEVTKGVVDEILGFDAGLWKELSDLSNLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV19</accession>
    <name>A0AAE0MV19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_143908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685368.1">
        <property type="nucleotide sequence ID" value="XM_062820977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV19"/>
    <dbReference type="GeneID" id="87858131"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3352073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="83" mass="9398" checksum="61E5100A488748B2" modified="2024-05-29" version="1">MSTNAVPNAIPIRQITITFLCGHTLTRGRTFHGSTSQTPSARISPPGAVSPLPRNYASIPCRSCRDNRIWVYDRFRRVWVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV68</accession>
    <name>A0AAE0MV68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP10 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_1515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685518.1">
        <property type="nucleotide sequence ID" value="XM_062821084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV68"/>
    <dbReference type="GeneID" id="87858238"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="369" mass="40870" checksum="987AE54BFC024D4C" modified="2024-05-29" version="1">MLSRATIRARTTASACLLCQWRSFSVSYQRLADKTPSPQTTKPTTPASTPASAPDAASKDAAPAATASPIEALRESGPLANAPRAYGKALDTFTPTHLSRPIGMHNPPNPGENTGIDTRTLQQKRDDFVNYDKHLKKREILKSKISRPYFRDWRNMQFHKGKTFLAPPRLFKADLSLYFPNLHGRTLAKDDAAKVADTTPLLEGHCSVVTVFSSMWAENQIRTFVSPEANPALQSVLKQSGGRAQLVQVNIEEDAMKAWLVRLFMGSLRKKVDKDDWKRYFLVTKGITDEIRESIGLLNSKVGYTYLVDHNCRIRWAASGDAEGDEKKGLVKGVQRILDEMTKEGVGKNYVRKTAAVPELKAGEAVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV89</accession>
    <name>A0AAE0MV89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_546573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684844.1">
        <property type="nucleotide sequence ID" value="XM_062829454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV89"/>
    <dbReference type="GeneID" id="87866608"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3351549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="93" mass="10715" checksum="BEE1988551030035" modified="2024-05-29" version="1">MVRSTPASALRYLLREYQGTARRSSSAQTPQQRRANLKFQKDQEARRGKSEDQIKKRVEKAPKSPISMFWLVVLGFIVFGGLVFEVLSRLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWE2</accession>
    <name>A0AAE0MWE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_587184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685310.1">
        <property type="nucleotide sequence ID" value="XM_062830965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWE2"/>
    <dbReference type="GeneID" id="87868119"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="592" mass="63387" checksum="C06E8C4FA135401D" modified="2024-05-29" version="1">MSIRIALENPPEFYTNLDIIRGQVVLTLSRPEQIGGIIVKLEGEAKSALGVPADGSGTGIAQKERTPTGDVIYENHKILYKVTQAFPPDEKSNALQQPYVLAAGQHRFPFQFKVPFNNACGDPVAMAKLGGLSGAGGIASGAGLFGLGGIRVMDGTKQLMYSHVTKTLPPSFTGFPGQCEIRYYVKVTIQRPGIFKENWRMATGLKFLPIEPPRPPKTNHEAYARRPFTFRPRSPMTNAPSKKRASFFSGWSGSSNAGSSSAPTTADGKLTTEPEVPPSIEMSARLPHPAIITCNQPIPLRLIAKKLAGSDAEIFLTAIQIDLIGQTDVRCHDLINTETSRWVIVSRQGLSIPVSRLGDAVGTEVVLPNDIWCNQPLPNTIMPSFVTCNLSREYQLEVKLGLSWGKPLASGSHAHASTSLFGRNKHEGADLAQEIHLPLHFSSVEVYSGIAPPAALIEAMKQGKNKRPQSRRPPSQPARPTTSSSAEAGPSTAPQQQPPALPPRTNTAQPPPAFSGVAAGVVPPPADPLYPPQLAPGQEEPPYDDAPPSYDEAMAEMMSGPVIPDGVPRPAYSGVTNENEPSTLPAVGNEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWY6</accession>
    <name>A0AAE0MWY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_417587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685880.1">
        <property type="nucleotide sequence ID" value="XM_062824097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWY6"/>
    <dbReference type="GeneID" id="87861251"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="2">
        <location>
            <begin position="177"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="514" mass="57781" checksum="31107969BE919C9C" modified="2024-05-29" version="1">MAGDSAVDIGQLSPEQQQALQQYTDVTGQEITDAMPLLERSQWNVQIAIAKFFDGEGPDLVAEAQAAQNEVPRVAGRHETLHETVWSDIAHQHGLHGANRTPPAPRVVPPRPVTYQAPSLISFLLSPFRMVLRVFASLFRPILYILSFIPQSLRPHALTSSLRKSRRSLLPKETAGRFRREFEEYYGTHDLTFFDGGHAQALDTAKKDLKFLLTILISPEHDDTDSFIKDTLLDPEVVAFINDPANNIIVWGGNVLDSEAYQVSMEYMCTKFPFSCLVCLTPKEGSTRMGIVKRIAGPVSPSVFIAGIRGAIEKYAPDLDSVRAERAAQDMARNLRSEQDSAYERSLAIDRERARQRREAAAAAAEAERRAREEAEAAERKEKLRQQWRRWRATTIAPEPDVSVKDAVRLALNMSQSSGRGRVTRKFAPEASLEDVYAFVECYDLLYPENDEEKGDVEESVEKPENYEHKYAFRIASVMPREVFEPTASVTIAEKMGRGGNLIVEDLVDEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX14</accession>
    <name>A0AAE0MX14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_544744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686871.1">
        <property type="nucleotide sequence ID" value="XM_062829320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX14"/>
    <dbReference type="GeneID" id="87866474"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="34"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="675" mass="74119" checksum="639CF2F5353911CA" modified="2024-05-29" version="1">MAEFTGSTQAQVEQPPVEYSQGYMNLTQTQRNTIEDVERIGASLSLLGVFLIFMAYGLFKRVRTVPNTFILFASIANVGASTACIIGYAGIVAGENSALCHTQAFLLEMFMQSDPWWSLAMAVNVFLVFFFALNPNAFRDYLWLYCLVCYGLPSIPAIVLLAHSPATTRYYGNATLWCWIADTWNPLRIYTYYLPIWSCIFLSGLVYFAVGYQVFHQRNQLRNLTFSNQGKNCSRSDHREHIELGEKHSYGISAGQNSPCPTVIPMDLTNHPGAYGTVTTQVEINISDNTDIQPMTCPTSPTPSITEVPLAAHPPGRNNSIHPWASNCSSSSSSSEDHIVPPTAVYAGSGSGSPPFRHVHVHHATDGTTTNGGCPKSSLKKTTYTTSQNRTYNHSGPGYGHTYSSYNRTSNTTTHVHTPSCSNSHHHNQTRFHHHNLLSSIRRPFRKFWAKLHRLDPIKLAYLRTSFVFAISILVTWTPSSINRVHSLLYPKNTSYPLNLASAVVLPLQGVWNAVIFAATTWVVLKEEVEGLWKGSWLGRWWEGRRGRQKRPGAGTAVEGFGGVQNVMGGQRGVRLGSDGLPPPIQPGGVVAGVDGVGAGKKNGNLNAGGYKAWRNGNGGSYGYAHHGVPHAPPHAMKDDFNETRSHCSKKKSGKKGPMDPNRLGTVRVIRGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX83</accession>
    <name>A0AAE0MX83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_54128</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687019.1">
        <property type="nucleotide sequence ID" value="XM_062829171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX83"/>
    <dbReference type="GeneID" id="87866325"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="280"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3355641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="592" mass="64973" checksum="6E112EC3CDBDC1F1" modified="2024-05-29" version="1">MADNAATTPAPPAEQQPPAAAPAAAPAAEGAEGEGPSKKAQKKAEAKAKKEAEKARRAAEREAAAKAAGKSTGPTEDLAKDNYGVVKERKGQFELSADVEDVNLKNIGEEHVGKAVIVRAWVQNARIQGAKMAFLELREEGAWTIQGVFAANNEGTPVSKQMVKFAAGINPESFVVVEGTVEKPLEPVKSCKVSNYELHIRKIFVLAAAPQMLGMTLAAANRPITNFSDEEPAPEKAAEEGVDKLSITAESSIPAATMLTHLDNIIMHKRAPVQQAIADIRVEVKDLFRSYLKSHGFKEFEPPCLIGAASEGGANVFRMPYFDKEAFLAQSPQFYKQFEIAGGRKRVFSIGPVFRAENSNTPRHMTEFTGLDLEMEIKKDYREVLLMLEGVLLHIFRGIKERCAAEIELVRSVYPAEEFLLPEPGKEVRLTFAEGQKLLREEGPEEYRNVSDDEDMSTPQEKALGAIVRKKFNTDFYVLDKFPEGARPFYAKLDDANPNVTNAFDFFLRGQEILSGGQRINDPEELEARIVQKGVDPKSGGIKEYVDVFRQAGVPAHGGGGIGLDRVVAWFLNLPSVHLAAYYPRTPKRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0L5</accession>
    <name>A0AAE0J0L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_592995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
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            <begin position="50"/>
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        </location>
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            <end position="83"/>
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        </location>
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            <end position="190"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KAK3334377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062827575.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87864729"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAK3334942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
    <sequence length="355" mass="40321" checksum="B128B498231D2AAF" modified="2024-05-29" version="1">MFPKMKQSARNTRGSSRSRLGSEMVHVLVGKEQRDFQMHKKLLCTTSIFFRDHIEAAQKESNGTDSEPEDSVLWLPEESPEVFELFIVWLYDRRAFQAYVDSAIEKAARDRVSPTSSPSRISPARQSPSRVGTTRHAETSDSGRRTLRWNLVRLHLFAEVIDLPALQDASMDALQDMYLLCDWDMSPGFISFLYGDCSLENAVRLRKWAVAMLAWTLHGGDGTSSQFEKLFAVFPKLKADYGIHFNKMAASKADIRIKNPQLRLPMNNLRSEERFFGFRQCSFHSHRSTVGEGVCPHLITGLEGIDDMETRSTMMGEDIISEEDEEELEGEGESSDNEEIITPVCDMETSFLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    </protein>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000016">
        <property type="protein sequence ID" value="KAK3334251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676417.1">
        <property type="nucleotide sequence ID" value="XM_062830337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J160"/>
    <dbReference type="GeneID" id="87867491"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="193"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3334251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="373" mass="40088" checksum="E559A11AC48A11BF" modified="2024-05-29" version="1">MKLRPCQVKSRLIRQALGRLRQPVEYCQILTTHPGRVDTRRTLTTSLNCLQLTTPTVKMATRRSARLSALAAAQPNGAAAPIVPPPAPKSRKRKVSAEDEAAAALLSSPAAQKPKPAAVSRLADPTKTNAPLLSPQTSRVVSSKNILEKACAHLIAVDHRMKHLIDKHPCRIFSPEGLAEQIDPFESLVSSIISQQVSGAAAKSIKAKFVALFDDPAFSQEEAKEDDGQNGQDDAAHPAAEGEPTPTPTKRRFPTPSQVLAKDLPTLRTAGLSQRKAEYMHGLAAKFVSGELSASLLASAPYEELVAKLVAVRGLGLWTVEMFACFALKRMDVFSLGDLGVQRGMAAFVGRDVKKLKNGKNGEGTERIRSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1K1</accession>
    <name>A0AAE0J1K1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_334189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677006.1">
        <property type="nucleotide sequence ID" value="XM_062823549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1K1"/>
    <dbReference type="GeneID" id="87860703"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29646" checksum="BB748878E69BBEB8" modified="2024-05-29" version="1">MRYLCQYRVLSMPSFSAPTSVLARFIEETSPDLTNCFGKTALHYAAFYPGTFDMTKRLLEAQANPLARDHLGHTPLHYSLLSEERELVRSSTTWTERVQTLMRAIFPENRQRALSEAILAAVKTGLEVQLDMVLNEKEEGLNLLLDIPDNSGYQALDIAYSFGKEYESATQKIIALGGKTGSNDKKKSPTRWNKDDRSEHLHVSEDGMEVSFVAYSLAPRYIMGAVRADHPIPTHRRHFYFEVEVVELPVREIWDYRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J288</accession>
    <name>A0AAE0J288_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_503187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677032.1">
        <property type="nucleotide sequence ID" value="XM_062827867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J288"/>
    <dbReference type="GeneID" id="87865021"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000012">
        <property type="entry name" value="Rhomboid family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="401"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3334866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="582" mass="65038" checksum="2808A9323E0BF0C3" modified="2024-05-29" version="1">MNCSLGVNAFRPGVQVAAHHFSKACSRLLVAAAPTTRCFSSTTLLPSRQWQANRGRLSSSTPFFGPSSIPRIAVRTLKFAARNRILIHYVDLPPNYKDEEGLPFRVDDLAAGEVLQLFGPGMTTPAANRLLKILHGRRVAGTLDDPVLKVNTAGYTPKDRRIALDYLRKNIHVDEVVNAGLRAEDELEALEKQQEEDAQAQAEGEDDVTKQLGYKSRFKVYEDDSEGLEESEKKKPEPQSVYGKSAFDAIRARNEAIWKEKLRKQEEERKKLEEEYKNGKAGPLAKADDTPKREVSAKRKEWEEWAMSDLKEPPKMPAWKRLLPSTVFVALLVAGFLTYSQLYVAPSRENRLWPDCPPAAATVAVLIGANVLIWFLWKVPVMWKPLLRYFLISPATPKAFSMLGAVFSHQVVWGHLIFNMPILWFFGTRLHDEVGRADFLTTYILSGSVGFLTSLFWLVLKGNFHMTTLGASGAIYGISAAYFWMHRFEGFKIFGLPPDPYTGVQGLAFIGLFGGLNIWGLFSKNHTMDVVSHLGGMVIGIIAGHLMEQKKKARLQGAGNTQLNLEDQKTGSGVLDTMLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6R1</accession>
    <name>A0AAE0J6R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_307019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677355.1">
        <property type="nucleotide sequence ID" value="XM_062823234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6R1"/>
    <dbReference type="GeneID" id="87860388"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3337904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="341" mass="38863" checksum="FB6D6F90C4FD1B78" modified="2024-05-29" version="1">MDEITTTPTTTTPRTFTLFPLLPTELRLAIWQASCHPRILEIHYCPSQDRCFTPSKPPVILSVCRESRHEALSRIYAKAFGTRTHPSGSIYFAPDLDILYIPRYYEEEGDFHHHQKGGGRGGSKEEQEKERTRRIMSMGYSETARDFGRYVLNTTELVKNLAIDHVRPEIRRPWETYSKFCLIRSFLKLERAFLILDNTTTTTTTTSTSTTATASATTISTTSGWVEEEEEEEEEDEEDQIEFIDPTESKEEIMRLMENVSASFTHEVGVGVTTRFEESSSGGRSNDQQHFDCCSDHVPAGRNGGDELALIPKTKVHHHHHHHHHSHAPWQSHTSSFVACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J727</accession>
    <name>A0AAE0J727_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyrroline-5-carboxylate reductase dimerization-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_560965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677535.1">
        <property type="nucleotide sequence ID" value="XM_062830158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J727"/>
    <dbReference type="GeneID" id="87867312"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="3">
        <location>
            <begin position="222"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="333" mass="36157" checksum="894777F2C3DBEC63" modified="2024-05-29" version="1">MDSPPSSPPLSATGETPFAVAPDRLTFIGGGHLAQAFVDGIYASFSTSNNGNSIWKHRSSRNKPCPITITARRPDHLRHLQTKYPLAHITLDNLDPQIWEEKPENSTEKEDYHHVLFICTLPRDVPSVCLQIAPAIASISSPSARPTIVTMCPGISVAQLQSWLPAGTPIVRSMPNLPVTVREGATGLFPCENARRGTKRTVQVVRDVIRLVSPAAVVLGREEELDVVAAISGSAPAHFYFLIESLVAAAETHGLDPETARELVVQSCLGSGMLSKRYCDRPVSVLRKEVCVPGGSTEKAINHMMDGGFPGLVGEAVTRSWRANREMSRVERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J761</accession>
    <name>A0AAE0J761_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_532059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677281.1">
        <property type="nucleotide sequence ID" value="XM_062828953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J761"/>
    <dbReference type="GeneID" id="87866107"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="90"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3337830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="558" mass="63110" checksum="5ED9F19F4910965C" modified="2024-05-29" version="1">MEENKEQSKSALKKAEKAAQMAAKKAEKAAKQATLPVVGGKKADDIIGITVKKSENFSQWYQEVVLKAELIEYYTEISGFFIMRPATMYIWNVIRKWFQEHIDELGVEETNFPMFLSQKSLEKEKEHVEGFAPELAWVTKAGDKDLEVPVAVRPTSEAVMYPWKPDYAKWIRSHRDLPFRLNQWNSVVRWEAKQTTPFLRAREFMWQEGHTAHLTEQAAGEEVLQILEFYAGVYEQLLAVPVVRGRKTEAEKFAGGYYTTTVEGYIPSNGRGIQGATSHCLGQNFSKMFDITVEDPAEKGKHIHVWQNSWGLSTRVIGVMVMIHGDDKGLVLPPRIAKIQSILIPVGLTAKMSAEEKDAHMKKVDELLATLKKAGIRADVDTREGYTPAWKFNDWELKGVPLRIEFGPKDAAKDVVSYARRDTGEKGTIPIAELTTKVPELLETIQQDMYNKAEASFREHRLKIEKWDDVVPALDAKNVVIIPHCLVPDCEDKIKELTTGRSDEAAEGPESQKAPSMGMKSLCIPFEQPEGLVKGETKCLNPECSRLAEQWCMFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7J6</accession>
    <name>A0AAE0J7J6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">B0H65DRAFT_319697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7J6"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="22929" checksum="EC5903391507EEE0" modified="2024-05-29" version="1">MAARLPASFIGSFLARSTPRQTCRFTRSAVTTTRWSQQLPSKSIRAYSSEAAPAPAPLYAKLKGDLKTAMRAKDAPRLAVLRAVLAAVLNASKTSQPIETDAQLVALLRKTARGYQEAADQFRAAGRGDLVEKEESQIRVLEEYVAGSGVQSVDEAELKDVVLAVQSELAAEGVDAKMGEVMKKLLGPGGRLDGKDVEKTTVARIVKEVMGTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J805</accession>
    <name>A0AAE0J805_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_474559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678104.1">
        <property type="nucleotide sequence ID" value="XM_062827250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J805"/>
    <dbReference type="GeneID" id="87864404"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="439" mass="48663" checksum="42F632A2A4AF8479" modified="2024-05-29" version="1">MAHTAHKNPLKEKFEAPEVIDRKAKVLAELIRKSKHFIVFTGAGISTSAGIPDFRGPEGVWTLMAQGRQATKKFVDTLQAIPTKTHMALVELQERGILKGLISQNCDGLHRRSGIRADMISELHGNTNIEYCKQCGKEFLRDFYAVAPDNRPLHDHRTGRKCPVCITQPLHDTIIHFSEDLPLAPWTRAEAHSEKADLCLVLGSSLTVTPANELPQLVGERAAAQQKKKPRQDVNTNLVICNLQDTDLDYLCLLPDHRIYARADDLIQRVMNYLGLSIPDFRVRRRLIVETDLDVTPAGGRHVVTVKGVDDDNTTPASFLRTVKLVTARGRPRIVKTEPFILGGRGKIGDLEEEALQSGAFAGGDEAAVMSEVLTLGLEFMGNYGEPSCELQHIVRASIPQSGAATQQPRQVARTAYELVYNPRNGEWVIECLQSSMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J890</accession>
    <name>A0AAE0J890_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_579716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678237.1">
        <property type="nucleotide sequence ID" value="XM_062830775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J890"/>
    <dbReference type="GeneID" id="87867929"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="468" mass="51046" checksum="13D9555158FE4112" modified="2024-05-29" version="1">MKSACPSPPEVSTYDELQEFKIALEDTISIALNFETTDHNASEQISDQVSGVGCAAYDPRSSSLDEAECIKGIKVSHTISRDWAWLTRVTCPANKVGRWHHPEHPKSKPNSASPYAAKFCFSKVISTQEALRDFAAFLDRLAVQNLTVEEQAAGVRRKIVVLSWDSNLEPKILDAFGFDLGKRNIEHWDLQLWSPVLYRFGDQDKTGGKTFFASTGVLGPEGNAVAMHNGSNDAWAELASFIRFLHMTEESFNRWILGMENLEPLDLSWVNPRFLLSNANLGGEYKDENPYLRCRNRKNKNRGVHHTKNASFEASNPVPHHQNAGPPPALHDAAAFPFLSATRQPAKAYVKSANGGWAKKPFGVTESTDRPLTKPPDVSPSTSSSTSPLSSTSPSTNPSTTPSTTPSTTPSTVPSPTSSPSPTPPTLAMDALAIISATTGNDSSKAGSSNKTTKKHGKGKRRRYIPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8I5</accession>
    <name>A0AAE0J8I5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_432601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678387.1">
        <property type="nucleotide sequence ID" value="XM_062825017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8I5"/>
    <dbReference type="GeneID" id="87862171"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="775" mass="85256" checksum="2F16F986EC722FCE" modified="2024-05-29" version="1">MAQRRTVEAIQSRPSTPQPQDSSLSEPHPDQSAQDEGKHRHHLQQKLRSPAPQPDQEKPQPLPGPSPSASPAPALLVPQPSSAGSAQAQTLSSTPGTATTATSTATTTSTTSTPDLQQPSKDASSATTCTPPVEIVETGAGQSITTSTHQDPRAPSETAPPLADTVSGQHQQYNQQQIGAPHNGSAPRVLVPTPMSHPQQPPSPPTPRQTPTMNYPAPSPYPPAGMPPGAQYAYGAQAVAHVDPYRTNQTALPSMRTFDHVQQQHPQHQMPLPNHMTVSMAPNQMSYYAPMHPAYQMHPGQSVVHYALTGLTPDPRIALSGGRHKKEIKRRTKTGCLTCRKRRIKCDEAHPACNNCKKSKRDCLGYDPIFKQQQQQQQQQHQQNLTAQSTPKSQHSAPASLTSTPTVPSSSVPPSPYQSQAQPYQQQSPPPHHYHQQSQQHLPAYQHQPHPTSYPPSHSSNTPYESPVSSTSPGFDYGSAIDPALSGTDTPSASGTPTPNSQLARPDDRNFGTKTVDDLIALGGAEPPIMNSPPSQAVIQEIKKLYGEIYVTGLSYFFETQWYDLKYDRGILAHHSIQVLLNNQPLMGLFGSFVEHISQPRADHKYASQLEECIVWGLAKLPLCTRGRGNNSTLTENPLCNPMVLGDLNTSRRNELEFWWYLAELAIRKPNRDLQNLRRLLDGQENRDFLYSLAVLREYSHHWNPANIEQQLPSQLAESDPRCRLAVAARFIRTAMEEGTTNVVRRFAQLAYRAYVHPGASLPANAAWRYEQESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9I7</accession>
    <name>A0AAE0J9I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_300918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678803.1">
        <property type="nucleotide sequence ID" value="XM_062823140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9I7"/>
    <dbReference type="GeneID" id="87860294"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="101" mass="11316" checksum="CB748EAEB07D3B95" modified="2024-05-29" version="1">MPGVEALLSLATLTLDCGRCPCDISSPFFKAHPEPNMRQLLSIGFRGGSVRWDVGVSWFVWVPGVEGNDFCFYFISEETGSKQPFKSILYNSLMLGHLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9R1</accession>
    <name>A0AAE0J9R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_295587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678631.1">
        <property type="nucleotide sequence ID" value="XM_062823074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9R1"/>
    <dbReference type="GeneID" id="87860228"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="352"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="789" mass="86868" checksum="668D57835E07982F" modified="2024-05-29" version="1">MMPFSRDLSDQGRLVHVSHAEMPEATNLIQSHLMTASPKSLSRRVSEESIRTEFCEGPVDSPYSPATPERKLPSALVYDRAELIHRLKRKESPTWVPGRHVESRLYEDEVQPSQQIPQTSISNGSCLLPPPAIAEEKQDGKWGLTDVKAAGQLESGLGIERPRSALHSGDFTPDDQTSDPRDRQDATQPRESHDFRHFKDSWTSRDPTSLPFSRQVMDYRKEAFGSPSSSLSSSLSTSFAYKLPTSPLVHTESREDIESETSSDGITSGSPNLRRHTINWAQGSSLSHGGMSRHTPPHRERALPYQAHQPRRSLASLSGLSIPSSSPQTPSMFRSRRLSHSSEGSPLQHASMVGSYEESILRGRMSTTPSKPLEFMAQIGVLGLGKCKPNLRCPSHVTLPFSAVFYRYSSTVHGRSKGEDGPSPYVGQIDLENGLPNPEELQRSKRKQQSRHAGRKSPDDDRIVHDIGDEALGGDGQRLEKTKKTSRSPKSPPGGSYRIPEKGQLQIIIKNQNKTAVKLFLVPYDLTGMEAGTKTFIRQRSYSAGPIIDGLKSTVPDGPPILRYLIHLHICSPSKGRFYLYKDIRVVFANRVPDGTEKLRNEVTYPEPRYMPYKALRTGHISSTPTNNAIATKRSQHAPSLAAGRRDENQSHIRQPSQDAGYLNTCLHLPRPAAIAADGDAMTGLELTEPPALLGRYDKLNRGDVGYGGNPFGHVTNGRPGSAESLLSKRLRSLGVQSLVADDAAENVVNGPVSILQERLENGSRDGPYVPDFGKPVGKGEERHCVGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA94</accession>
    <name>A0AAE0JA94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_471577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679133.1">
        <property type="nucleotide sequence ID" value="XM_062827109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA94"/>
    <dbReference type="GeneID" id="87864263"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042157909" evidence="9">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3340191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="431" mass="46019" checksum="7B140373A14D7053" modified="2024-05-29" version="1">MGNLLILLALCVVMALASFFAGALPLSLSLSQSQLRLISSIGVGILVGTSLIVIIPEGIEAVATTNTVQPAHSHNAAAARRSLMGVGGRSPSQTVNWHISGNHLEARNGNGDEIPHIKTHKVVTAEQILKNLRKKRDEEPKEDTKSSFQKSTNPTTEKHDDDNDHHENALPTFQIGLSLTLGFALMFLIDRLPQHAFSSSSSSTPQTRHISLDNLETSSISESVLEGRDGSSETDGFLSSFLSPSPKQARTLATTVGLVIHAAADGIAMGASATTEDMRLGFIIFVAIMVHKAPAAFGLTSVLLRQGLSKRAARGHLIVFSAAAPVGALVTYCIVELFLGGSGGKVATEGSGGEQWWTGMLLLFSAGTFLYVAMHAMQEDSNSHDHHSSSNGYADGSSSQQRRQPKPLRDTMFTVLGMLLPLLTQFGHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB00</accession>
    <name>A0AAE0JB00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_430167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679301.1">
        <property type="nucleotide sequence ID" value="XM_062824864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB00"/>
    <dbReference type="GeneID" id="87862018"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000081">
        <property type="entry name" value="Ribosome biogenesis protein Ria1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3340359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119009" checksum="C995CC95C01B8439" modified="2024-05-29" version="1">MPVVQPEKLAKLQQNADDVRNICILAHVDHGKTSLTDALLATNGIISPKLAGKIRYLDSRPDEQQRGITMESSAISLYFSMLRRSAPDATPEAKEYLINLIDSPGHIDFSSEVSTASRLCDGAVVLVDAVEGVCSQTVTVLRQAWTEKLKPLLVINKIDRLVTELKMTPGEAYIHLSKILEQVNAVLGSFFQGERMEEDLNWRDRMEERVAAAAAKEAQIAAGQPDSGELQFQEKDDEELYFAPEKNNVIFGSAIDGWAFTVRQFAGMYEKKLGIKRGLLEKVLWGNFYMDPKTKKVLGPKHLKGRPLKPIFVQLVLEPIWAVYQATVGGDSGKGDPALLEKITKSLNLTVPPHILRSRDPKLLLNTVFASWLPLSTALLVSVVESLPSPKAAQADRLPDLLASVPGADHIDPKVKDAMVSFKKGPSEPMVAYVSKMVSVPESELPENKRRGPLSPEEARELARKKRAEVIRAQGGADGDPDMNDLANAFTSTSLIDNAVPELEEKPVEAEHLIGFARIYSGTLSVGDEIYVLPPKFSPADPYAQPVPKKVTVTALYMLMGRNLEALPSVPAGVVFGIRGLEGSGLLKSGTLCSQLEGSVNLAGIANLAGRPIVRVALEPVNPYDLDKMIQGLHLLVQSDPCAEYEHFSSGEHVLSTAGELHLERCLTDLRERFARCEIQTGAPIVPYRETIVRAEEMRPPVNKELGRGVVVGVTSSKQVTVTLRVRPLPAPVTEFLLKNAAGIKRLYTDSKAAGVEDGAESPSVEATLENGTPSDVKIEEDEEVSQATTTLTPEELKKQLEAQLEGIKDKEVWKDVIDRIASFGPKRTGANILVDATKDQLFSKAFSADKIRNQAPTGDEKLHPAHFSDKIMYGFQLATQQGPLCNEPVQGIAVFVEEVLVAQTEDDEASSARDRIGRLTGEVIKTVQQSIHKGFLDWSPRLMLAMYSCEIQASTEVLGRVYDVLTRRRGRVQSEAMNEGTPFFTIQALLPVAESFGFADDMRKRTSGAAQPQLIFTGYEILDEDPFWVPFTEDDLEDLGEFGDRENVAKRYMDSVRRRKGLLVEGRNVATNAEKQKTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBE9</accession>
    <name>A0AAE0JBE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_430990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679855.1">
        <property type="nucleotide sequence ID" value="XM_062824918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBE9"/>
    <dbReference type="GeneID" id="87862072"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="165" mass="18416" checksum="F4E353BB4D001863" modified="2024-05-29" version="1">MYPSRLRAAQQLSRQCARSFTTSGRQLYSSSTVPAPEKNGEKTVEITPTKPAAVVKQAPNRAEVWSKSQKPRSEAMTGPRFEQTNFDLQPQPWAAIELIHKQPVKWVHERIVACDGGGGPAGHPKIYINTDKPEIASCNYCGLPFANEHHRKHLESLPQTSYPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBF9</accession>
    <name>A0AAE0JBF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_579053</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679870.1">
        <property type="nucleotide sequence ID" value="XM_062830749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBF9"/>
    <dbReference type="GeneID" id="87867903"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="108"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3340928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="747" mass="81839" checksum="6DD1DAAD06F3AD24" modified="2024-05-29" version="1">MSAVARHAAQGLRVRIGTWHLNKTSIPSSRHVATAAAATPTTTTSAPASIVRNGSSSAPVDVSIGAPLSTPTIESEEPLRHPAARTPTSSRRDTLKDAKPFSDFLTDTYNRQHDYLRISVTERCNLRCLYCMPEEGVPLAPQKELLTTPEIVLLSSLFVSQGVTKIRLTGGEPTVRRDIVPLMQQIGALRPHGLRELCLTTNGLSLHRKLDAMVEAGLTGINLSLDTMDPWQFQLMTRRNGFSAVQKSIDRIFELNRLGAGIKFKINCVVMRGLNDREVLPFVEMTRDKDVEVRFIEYMPFDGNKWNKGKMFSYQEMLELIRSKYPDLQRIQGHKNDTSKTFQVPGFAGKVGFITSMTHNFCGTCNRLRITSDGNIKVCLFDNTEVSLRDIVRKINQGEPIDEEAFEVMRQAALEKAGQAFADGTSPLLAPNSEELLNIIGIAVKNKKEKHAGIGDLENMKNRPMILIDTNTNATSQHRFQSPGRNSHQIQWNHNGLSSLLSPPTNNTSNSFTHRKLQGTSMFVPPPTSNVPPGLRHVRLLSTTRTFFSSSSDNNGKEQPTLNTGKEQPKLTHLTPTGEAHMVSITTKTPSSRTAVARCTVHFSNPTAYPLVVTNSLKKGDVLGVARIAGIMAAKRTPDIIPLCHPIQLTHAEVELMPVGPVAAPVEGSSESGYGYGYGYIDITATVSCYGKTGVEMEAMTAASAAALTVYDMCKAVDKGMRVEGLRVVMKEGGKSGNWVEGESVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBU1</accession>
    <name>A0AAE0JBU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_270739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679738.1">
        <property type="nucleotide sequence ID" value="XM_062822748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBU1"/>
    <dbReference type="GeneID" id="87859902"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="124"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="464" mass="50997" checksum="FBDDE9EEA18D11C5" modified="2024-05-29" version="1">MTTASTAAAAAAPTPSAPSASPAVTVTAQSQGPAPTRLSTPRPRTPKASSEPSSSTNNNLKASTRSRTKRGSPSPQSNSHRTDPLSDKATVYLIRRILCPQHQDKGKTTPPISIEDVLPPLTSRNDVDLQLYALIAIILREYVQNWYNKITPDDSFVAEIVQLIAHVTRALEQRLRNVDLESLLLDELPDLLDRHVTAYRAAHNPITQSPLQTDAREIYHALCPLPALSPVPCSGSPESIAEQAENEAAYRQLLVHAVLAVLLPTEDLQNNCLVALVGQILSELIIGNILANKLSEPWFIWECFSIASNVITRRTSVENEPLPPRKSKVPVQARSSSSIQSIQALFWTFIHWIFLSISFVRMAITILTTSHSLPPRLSRSATAYEKVAAHHTTQLDLEKHAGSSDVEPERFKTPVLAFRCWSAISNLIEMDGRMAWLSGTVSMLQWIMMRSPGRLGGVDGSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC26</accession>
    <name>A0AAE0JC26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_474016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679871.1">
        <property type="nucleotide sequence ID" value="XM_062827226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC26"/>
    <dbReference type="GeneID" id="87864380"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="159" mass="17679" checksum="25C71CD2CDB49BBB" modified="2024-05-29" version="1">MRNSHTSPSSPNFCFLPLPVKRVPFPFASRQSKASSIKHLASPRRLARISPHLFPPSPTPKSDVRTLPWWLPSAAPAAGRALTAPVGQFNCASIDKVAWTHCKRRQDREGLRDHVTALTQGKKKSERVPLSPLNVLLAVGDFQRTRLFRCVTFSKSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCQ4</accession>
    <name>A0AAE0JCQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_427610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680233.1">
        <property type="nucleotide sequence ID" value="XM_062824701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCQ4"/>
    <dbReference type="GeneID" id="87861855"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3342440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16111" checksum="A90771FBD519C459" modified="2024-05-29" version="1">MTLKDEFATRNFSIYGQWLGILSMILCFALGIANIFTFRVIIIVFSVITLCFSFVILFVEVPLLLRICPTSSGFDNAIRKISTNYMRAAAYGVMAAVVFLSNIDRATSLIVPGIFLSLTGLCYALAAFKGQAFVGSKTLGGAGVAQMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCX8</accession>
    <name>A0AAE0JCX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_279390</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679972.1">
        <property type="nucleotide sequence ID" value="XM_062822856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCX8"/>
    <dbReference type="GeneID" id="87860010"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="408"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="312"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3341030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="619" mass="69579" checksum="E2B4EA043522EA2A" modified="2024-05-29" version="1">MATDDTPPVPAPAAAADPVVETTNAESNDAADNGDRNDRGQKRGRGRDNRNPNRDRGNPNNIKTGGFGSNKRDFLSKRDQVQDNRAAKRRKVIDGAADGNSYMSIPFSTDEIAAEERRPKRKVAVLIGYAGTGYHGIQINHKEKTIEGDLFAAFVKAGAISKANADDPKKSSLVRCARTDKGVHAAANVLSLKLIVEDEDIVEKINSHLPDQIKVWGIQRVTNGFSCYQACDSRWYEYLMPSYALLPPQPQSFLGKKIIDAAKEKGTYDEYVDRLDDVKNFWEEVEKNDIQPILEKMDPEIRAEVIRILHDTADQELTDDGEPSKPDTDVTKDVDMKDTPAEETTATEPSKDGEAATTETTETQAPAAKVEREFTPVELAVREVKAAYVAAKRRYRVTTPRLEKLQEALNQYLGTHNFHNYTILKSHTDPSARRHIKSFEVNKTPIRINDTEWLSLKVHGQSFMMHQIRKMVAMAVLIVRCGAPMSLVSESYGPRRISIPKAPGLGLMLERPVFDVSNKKFKELGREPIDFGKWDKEIQAFKDEHIYKRMFELEEKENSFHLFFNQIDNFRTDYFLWVTPGGIEASHERSDRTAEKIPRALQAELGDEADGVAEDGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD12</accession>
    <name>A0AAE0JD12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_589892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680712.1">
        <property type="nucleotide sequence ID" value="XM_062831050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD12"/>
    <dbReference type="GeneID" id="87868204"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="114"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="643" mass="70138" checksum="C948468466D15D2D" modified="2024-05-29" version="1">MAPPPNSRSPGVLYWGPRLFLGSLAIAFLIHLNHPASSFSLSSLFSPNSESAITAITYCYTSILTSAGSSSEADCFSISPDGKFTKVFHSAEDVLVVGDNDNNEGGGMGGSSAVVEMKEGHVIPGIWDGHGHLIQYGEFLHSVDLFGASSVEMVRERVRGYLKERGGEGSDVGSKENWARGVGWDQMVLGEMPSAAMLESDPALKGKYIMLDRVDVHCTWVSQAILDLIPPESLPEDVPGGEIIREPGMGVFCDNAMDIITSLWPKPDAERKKTFLKSAMKELHKVGLVGMNDAGVTPTDLKVYEEASRNEDWWTLRVYAMIECGERNVFCPLKADSVKTQHEDGMLTIRSVKLFADGALGSWGSAMIDPYSDKPSTRGSLLVNGSTLESLARSWSNAGYQVNIHAIGDLANRYAIDALEAALKDSCPKGTSLKDCQNQSHRFRIEHSQIIHPTDQARIRDLGIIPSIQPTHATSDMAYAESRLGPERTRTEAYRMRSLIHELKVQPVLGSDFPVEPPNPFEGMYAAVTRKNPHTGKGVDGDNKGWYEEEALSLEEALAGFTEGVAGGMFTEGKTGVIREGAFADWVVLDEPLEVLAAREGGEGLRKIKVRETWVGGRKVYDREEEASEKVVNGGEEGVREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDC6</accession>
    <name>A0AAE0JDC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E1-E2 ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_469323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680578.1">
        <property type="nucleotide sequence ID" value="XM_062827003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87864157"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1261"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1294"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="296"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="390"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3342785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1330" mass="142507" checksum="AFC435DD5035A1EA" modified="2024-05-29" version="1">MKPTNGIPTRRRQQQQQQSSSATTGTETSDITASKATITTSFLISNLHCPSCVSTIKDVLLHSEPSSGSHIRWVSPNVVTSVVTVEHYDSGSNSAASVSSLIRDMHRALEDSGFEVSGVTTTATSTVGISDNDNNNNDDNGFLVRRDLGIVAENDGGHDANIPGSSRPQASLPSSSSAFSRWVTTASRLNLGSLPGAAQSQKLAEAHLQNCEQCRTSKATTTGHQVEEKKTSEKEKESVGGPKSSVSEVRRGNAPDFAAARQRNMASTSTTKSLISTDTVVDLGKVPSSQSPPPLYRATVAIGGMTCAACVNAITNELNKKDWIANVSVNLINNSAAIDIHDESRATELVEAIEDLGYDAKLDKVVALVDPQPKPPPKAKARRESSSDTWRATLSIGGMTCASCANSITNEMRKRDWVQDITVNLLTNSATVEFAGGKENANKLVGEIDDLGFEATLNEGTLVNVAIQEEEERSNPEEEQQRREVEIRIQGMYCEHCPSRVSASLVAGFRRQLDVISQPSHKRPIVKVVYVPDAPEFTIRHILRAIEASDPAFKASIYHPPSLEEQSKAIQRHHQLQILWRVIFSFVVAIPTFIIGIVYMTLVPSSSGNTSREFLMKPWTSGISRAQIALFILATPVYLFAADIFHRRAYKEIRTLWRRASRVPLLQRFYRFGSMNTLMSLGTTIAYVSSVCQMIAAGAQKVHMVDDSNFYFDSVVFLTFFLLVGRLIESYSKSRTGDAVEMLGKLRPTTAILVEGYGTEKERDEVVQADSLDYGDVVRIPHGASPPADGIVVRGQGSLDESSLTGESKPVKKAVGDEVYTGTVNKDAPLLVRVTGVAGKSMLDEVVKAVREGQTRRAPIEQVADILTAYFVPVVIAIAVATWIIWLAVGYSGHVSDDFLGDTKGGWVVFALQFAISVCVVACPCGLALAAPTAIFVGGGIAAKHGILAKGGGEAFEKASRVDCVVFDKTGTLTTGGEPKITDSEVFGAAADEENGMVLAALKAVEENSSHPIAKAIVAFCAAKTSAKTQVEDLQEIAGKGMKARCLGVDSQDDFDLMVGNEALMEDFAVTVSDQTVQTLQKWKSEAKSVALVAIRRHQGSDASGWLLAVALAISDPIRPEAPLIVKALQSRGTRVWMLSGDNPVTAAAVAHQLGIPADQVIAGVLPTGKADKIRYLQGTEKARVGKDSESSTRRAMVAMVGDGINDSPALATADIGIAIGSGADIAISSADFVLINSDLRGVVTLLDLSATVFRRIKFNFGWAVVYNCIALPVAAGAFYPIVSDGNHVKLDPVWASLAMALSSISVVLSSLALRSRVFGIGFRARKIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDR9</accession>
    <name>A0AAE0JDR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cryptococcal mannosyltransferase 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_443895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680933.1">
        <property type="nucleotide sequence ID" value="XM_062825653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDR9"/>
    <dbReference type="GeneID" id="87862807"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3343140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="389" mass="43954" checksum="CC18F5CBA7CF8FC4" modified="2024-05-29" version="1">MPLPRHYTTVRHSNPPLSSENRAAYVAAIMNPDEKNLPRLECPAFNPSRYEYLAVQGDEGDSDPSGIQYFFALDLRECLHLLPRLIGSIVEAIRFLGPQSCALSIIEGNSHDGTAEVLEALRPELDALTTTYYFKSSDINPKQGDRITKLAELRNLALQPMLDPNNSELYPPEANTTVIFLNDVAACTDDILELVHQRRFLGADMTCAMDWTYVGQDPTFYDVWIARTLAGGDSFFNIPADGNWNSAWNLFWNEPTARERFFAHQPFQVFSCWNGATAFTAKPFLEKKVTFRAPRKGECMQGEPQLLCKDFWWHGYGKIAVVPSVNLEYSDEKGKQIKEAKGFTSQLVGGEGHKDDAIQWQTSPPEKVKCIPDYGHQFFEEWNKTQPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDS5</accession>
    <name>A0AAE0JDS5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_245012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681075.1">
        <property type="nucleotide sequence ID" value="XM_062822380.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859534"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055795">
        <property type="entry name" value="DUF7371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24086">
        <property type="entry name" value="DUF7371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042162755" description="DUF7371 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7371" evidence="3">
        <location>
            <begin position="1908"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1572"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1781"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1572"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1827"/>
            <end position="1839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3343282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2130" mass="203500" checksum="C12B49D29DEF1267" modified="2024-05-29" version="1">MRLNASLGVLSGIAWTTSGAVVPRNLDYDIDTTCTSTETGHGTVFVTVPGGDSPTAAAGSVFTLTVPVGGSDPAAGSPGSFGSPSGSGNNGLLSSTCTTESSAFGSPFGSAGTLEPVTITVTALSPPMSTVTIPVSTITINTPGAGSGAGNNGNGNSPGSIVTVTAPQASPSPAFPGYPGSGITVTIPGGSGSGSVSGSSPAGVTVTVPQISGQAGEVVTLTIPEGPNQSATVVLTVTIPDVADSPGSWSTIVSAPGLDGATSGPLVTVIGGTSAGPQVPTNLPVPGGLLSSTCTDALTLGAGGSGNTGSGNTITVPLPQLTTIHGGKESYPPFFGSLNPLTITYTIPAEPGMSTPLVETLTVTPNLPYPPGDPGSSYGPTDLTIPLGPFGVSSSAPVGSSSGFTLVTYTVPADGNSPGYTGVFTLTPGAGSSPGQGGQNGGSPVTVTVPEATQPGQNGGSSGETGYPPYGGSATSAGNGSPDTVTLTVPQAGAPTQSFSGQGAGQSGFGSGNQAPTVTLTVPAGSTPGSGSGGQGSGPGYNNGQSTCLILTIPGANSVGQSSLLTVTVPAGSGFPVGGSPSVPYNGPSGPVTVTAFPSPGASGSGSSPSGSGDDDQSTCLTLTLTGANGQPSLVTVTVPVASAFPDGGSPSVPYNGPSGPVTVTVPPTPDASDLVPGSGSSGSGDDDQSTCLTLTLTGANGQPSLVTLTVPVSDYLPGASPSAVDSNGPSGVVTVVVPETTGSSGSSSGSGPYGSGGNGPSGVLTVTVPNNSGSGSGSSASDPYGYGGGSDQSGVFTVTGPAGSPSVATGSPVVVTYTVPAGPGETESSYPVTYTIQPSSGSGSGSGSGSGSSPSVSGVPAGYGSGGSNPFGPGSNPTDSSGGFSPVTVTLGPSDGFATPVVVTYTPGVTVYPSGSSPTPSEVIISESGTLFTITLPASGSLPSATSPASSEIVVSEFGTLLTITVPATAPPAQPTVATGSAIVPGYGSGAGSGAGSLPSGLTVFTITPTSGSPYIVTVPVGGGSGSSPSNVLTVTEGPSPTGSGTGSGSGSSPDNGEFTITIDGTPVVVPLPQSNTGANPGQGGILTVTEGLPSGLPSIVTVPAGAGGITAQPAATPYGGSFPGGEVITVTGPDGYPTVLTIPGGGNPAATQSGPSNVLTVTEQLTSNTPGQNGSGGSVITVAGPDGSPIVVTIPSGGDSGASAPVSGLGTAFTLTLTPGNGGFGSTAGVPGILTVTELAPTATGGAQLGAGGPGSAFTITLSPGSGFPGSGSGPQGSGPQGNGPQGNGPQGYGSPNSLGPILTITEGGAAPTGGAQPGGNGAGTAFTVTLSPGNGQGSGPQGSGQGNGPQGSGQGNGPQGYGSPNFPGNGQGSGQGSGPQGNGQGNGGPGSAFTVTLSPGSGSPGSGSGSQGNGPQGYGSPNSGLGPILTITESPSGAAGGLQPGATGFATALTLTIPSGSGNGPSGSGNGPFGSGNGPFGSGNGPSGSGNGPFGSGSGPQGSEQGSGPQGYGSPNAGAGSVFTITQGGAGAAQPTGPVLTVSEVVLSETIPIGSGLYSVVAFTTTLGSGSGSGSGSGPASGPSIVTIDPNGSGNGLNSPSAIGGGAFATTLTLAQPSAVIATAPAQAPQVITVLPSIFTVWPQNTLLTTTSCTTSNGDAFFDPGQNGGFGPSVVTMWPTYSIDTTCTESSTSYISASAVAPASSSESSTVLMLSSSTLAVISSGPSQPSPSDSSTVLMLSSSTLAVISSEPATPSAVAPEPVSTASDEQAIPTLTAEPAEPTSASGPDQPIEPTESSGGGQSIPVVTPEPSSSSDEQAIPTLSFEAPPESSAGEEAPPPQTEFGLGHIHPRAAHVTVSAFSLSASTASVPADVTAAPSVISTPSSVAPVPASTASVACGSLSDRGGYTFRFDDIPAPATTNDDTNSAMIVRHQPVPRPYHRFLFSDDFRVVPPPQSRFVPSSGSQMVQYDGASKNVAQIGLAQLRNNPCFRFDFLGVSLGCNSTAEPCVFNVKGIQWNGVRDVIQANKTFVVGACKNTDSCGLSHQILDSAAALPFTNLTAVNITLTVAGKPVTWWADDLQVAWTENDCATAACRALVPNTASTPQKPWGVSEEVKAKGLRWSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDX3</accession>
    <name>A0AAE0JDX3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_236665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680801.1">
        <property type="nucleotide sequence ID" value="XM_062822271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDX3"/>
    <dbReference type="GeneID" id="87859425"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3343008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="200" mass="21650" checksum="F9495ED773896A14" modified="2024-05-29" version="1">MKAILQRVLSASVTVDNQLVSAIGQGILVLAAVAPGDTVKEAEALASKVLKLKLWDDESGGRWKKSVQDIGGEVLCVSQFTLLASTKKGSKPDFHGALGPDEAKTLYDLFYKKVQEGYAAEKVKNGVFQAMMQVALVNDGPVTLEVSATPAAQQQQQQQKKKEDRKLNQKQQKQPQQPQRRAMEDGQAAADKVSGSTDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE30</accession>
    <name>A0AAE0JE30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_588438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681282.1">
        <property type="nucleotide sequence ID" value="XM_062831003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE30"/>
    <dbReference type="GeneID" id="87868157"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042174955" description="Ecp2 effector protein-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="3">
        <location>
            <begin position="208"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="343" mass="38106" checksum="B5DEFDE8C1F7DC57" modified="2024-05-29" version="1">MLPTNLRSILAVIAVAVTVSANPYPKLIGCVDVVDIKTGKVADCVPVGQLPNGQDSNHTKHQGKHARRRAKANENNLCVNLKFNTQSPSTTTGPDQNRCVSFSTLRQLQTDYQYQHSLKPRGDEGDNVASNEPCLDVYYLSPKDNTTMTGSCVPISDLEKYETVTINPIDPPSDGSPNDPYGDLSSKRDFGPGVNYTFCTEPYDVIPHLQYESPHYLDCVMIPANALGRSRYFTYRTSNDAYTLLTAKTCELALRTTGTVVKKGEILKIGNTDIERSYLHGVKAINDLPANAGGKQQLWYAQGFEVEGKWKCWDNAETQQYQVYFGYKLKGSKPAWWEGMGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEH4</accession>
    <name>A0AAE0JEH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_427862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680812.1">
        <property type="nucleotide sequence ID" value="XM_062824712.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861866"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="96"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2192"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3343019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2276" mass="246162" checksum="656E9F31110BFA9E" modified="2024-05-29" version="1">MAPIAVTPDSSTASPSGDSSNGYFHVRNGDGHNSISNNGHDHGEHAHSAAVGNGHCNGNGAPPDGLRIDTNGHGSWTADSGPGSGSPLPPPRHLQDMPIAIVGMACRMPGNVSTPAEFWELCTRARSGWSEIPKQRFNSARFHHPNQGKGGTLNSVGGNFLNVDLAAFDAPFFGLTEKEAISMDPQQRLLLECTFEALENSGIPKHTIVGKDVGVFVGGSFPEYESHLFRDPDTIPMHQATGCAYAMQSNRISHFFDLRGPSFTADTACSSSMVAIHLACQSLRTGESSSALVGGCHLNMLPEFWVSHSTCRLLSDTGRSFSFDNRGTGFGRGEGCGMIVLKPLDQAIKDNDPIRAVIAATGLNQDGKTPGITMPNGSAQEDLMRQVYGNAGLDPNLCGFVEAHGTGTRVGDPIEATAIHNVLGQDRSPRNPLWIGSVKSNIGHLEGASGIAGVIKAALMLERGFILPNHDFKQPNPKIPWKEWNLKVPVTQRPWPRGKKYISVNNFGFGGTNGHIVLTAAPFLGSRTSGSSHDGTIMASDKSGPGRKLYVVTANDKAALSQQMKNIVVYLEQRPEIFQVDLTSNLAYTLGQRRSLLQWRAAIPAINSFELIEAINGEKVITGKETEPLRLGFIFTGQGAQWYAMGRELYEQYPTFTASILLADACLTALGAEWSLIEELGKDAKTSRISEAHISQPSCTAVQLALVNLLRGWGLRPTAVAGHSSGEIAAAYAAGIVDFESAMAIAYHRGRLIPILKQKYPELQGRMMAVGGSKKEFIPLIEGLQAKEVRIACYNSPSSLTISGDEPALAELERICEKRQLFNRRLVVDVAYHSHHMNLVAKDYRASIASLQLPARTDVQFHSSLYGHLVDGTDLQPNYWVDNLTCPVRFSEALQSMLAPVGEHKHGVNMLVELGPHSGLQGPIKQVLKEVGGSAPKIPYASVLIRKRNAVETALELAAQLFTRGANLDFSAVNFPKPTKPPTLLTDLPRYPWNHSTRYWQESRMTDMHKNAAGSRSDIIGTLANYSSDLEPTWRNIVRLDDLPWLRHHKIQSLIMFPMSGFLAMAMEAASQRAKSKHCSFDRFQMRDIAITKPLVIPDNDIEVTISLRPHQESIFVSSETWDEFRVCSWSSGQGWIEHCVGLIATVKTTDNHVVQGLQTGNGFEDHLHSVAPTIDNTQWASVNPQHMYETLNKLEVVYGPTFQGLNNINACDTQSTGDLVAPDVAKEMPGGYLTEAVIQPAFLESLIGMYWPILGAGRRQVDTVYLPSSIEYMTLSSSITQLANEPGNTLRAVCKGEVFPGIHRPFKVHMVAAPAASLESTISIDGLTVSPMLNGDTLEKSSAPRDLCYKLEWEHILKPDHMRNQLPVGAQIVIIHEDSNFQQLVALGLANALEQATGRLPEVGKLDTVDPEGKTCIFLNELHHPFLATLSPSQFFGLQKLLIGVEAILWVVKGAYDKCTEPEANMVTGLSRSIRSETALRFATLDLDAALPLSEAKAAEVIFSVFKIAFGSASSSMSELEFMEREGSLFTPRITHDRETDEEVHNLTNPRALEPTAFGDNGRLLRLEISAPGALDTLHFVDDHSLELPLAIDQIEIEVKAVGMNFRDAMAAKGQIPITMSGAEASGIVIAVGSSVCAFKVGDRVAALTQGAFATRTRATASLAFKVPGHISLEAAATLPLGYCVAYYSLVDVGRLAEGETVLIHQAAGAVGQAAICLAQMIGAEIFATVGSAEKKELLINEFGLPSDHVLYSRDTSFGPTIRRATYGRGVDVILNSLIGDGLRESWESVGKFGRLVDIGKRDSASKPRIDVSAANRNASFISVDIFALLAERPKVLKRVFADVARLLRYGKVRPVSPLSVFPVSDVEGALKMQQSDSTIGKTVVALGGSDLVKAPPSRRSKDLLHSDATYILVGGTGGLGRSIARWMAGKGAKNIVLVSRSGSVTGKVKELVEDLSVLGVSVHVRRCNVVNKAEVDELIQTGLRGLPPIRGVVHGTMVLRDVLFEKMTWTDYTEVIEGKVQGGWNFHRALLSSPLDFFVAISSAAGAVGNRGQAAYSAANCFLNALVQYRLAHGLPASSLDLTAVSDSGYLAEDLEKAAEVARNLGSDTICEAEVLALLHAAISGKLTLACTNHAITGMRITSTVRPFWTEDAKFKAMRIAAEDEAAKNASLNTVVSFNAALKGARSLTEAENVVCKGLVEKISSVLMLDAEDMDITRSLSHYPLDSLVAIEIRNFITREFEANLQVLELLSSGSIQTLAKAVCAKTKIVSFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFL6</accession>
    <name>A0AAE0JFL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nacht nucleoside triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_524707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681721.1">
        <property type="nucleotide sequence ID" value="XM_062828823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFL6"/>
    <dbReference type="GeneID" id="87865977"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="452"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3345108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1150" mass="130699" checksum="941D213A9C8F4212" modified="2024-05-29" version="1">MDVNEGISLAVWTTVLCLFVCATAAWLWFYAPAGSGTAPSSLAKPASDSTRSTQRGVHLNQVNKDNGDTDIDIIAIHGLDTKSPDTWTWRDRRNPNVSVNWLADLLPVDVEKARIFTLDWPADLLQPSDLVPKLDDEIVTLLIDGIDRELLAKNKTRDRPILFIASCLGGIILMRALTTPPNHECTTSCHCLRKATRGIIFLATPFRGTSFQEVAHWADPGLTAWALIRDRKVSKLLDSVKGSTFELEELVRTFTRFCQHPNWPFLVFNFYELGMTSLWRKIFPWLPTLFFKGKPLVGRSSATLDIVLESLPLDRTHGLMNKFGSRGCADYKKVAGKINEFIGKIREGTPLAQADAWIREKCYTEDRLKIERLSGTKLPMDQCYINLFIIERTGEDKDRSNKKSAKESVSQSSPFSLTARLKVETPDGTIQAYLPSLFKEREGPDGRKTQPRRIFIRGRAGAGKTTLCKKIVYSFMHGEWPEWTELFDRVLWVPLRNLKLEERRRQAGYNFLHLFSHEYFSRPKSRKDLAEVLSDTLFGVPGKRSRTLFLLDGLDEVSQDLSEGDMSGFLNELLEQPNVIITSRPYGKPPAGLDLELKTIGFYPKQVKDYIKMAFNDQETANRAQSFLKSRSFIQGLMRIPVQLDALCFAWDNKNVNDSSKLDTMTDVYRAINQSLWKKDIPRLEKKHDDKLITAARIQQADRTEVENHVLKEILFLESLAFTGLQNDIIEFESEHLGQISDRFVRDISPSMTVPCLSFLRTSDSPAKFSNQTYHFLHLTYQEYFAARYFVRQWKTNKPLEYLALHGRKNENNTSTTAMQFLRKNKYAARYDILWRFVAGLLDAEGKAEGFFHAIEDEPHDLLGPTHQRLVMHCLSEVSTEMSLRKRLEVKLKEWLLFEYKFTGKTRLASEAEFPESALLDTMQEVGIDEKIRILKSVAIRPTIPPSIVILVTSWLEDGEFITGKKDVLLALQAQSSLSNELLAAVVARLEDDDWSVRPAALGVLQAQSSLSNELLTAVIVRLGDKNGGVRWAALGVLQAQSSLSDELLTAVVARLGDKDWDVRKAALRVLQAQSSLSDDLLNGPFVEPLFKFLLRGSFDEQWSWYVIDKTSCINMPEWVGRTSIDNGKEFMNMVTRARDSIYGCDERQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG25</accession>
    <name>A0AAE0JG25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_494831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682270.1">
        <property type="nucleotide sequence ID" value="XM_062827781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG25"/>
    <dbReference type="GeneID" id="87864935"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="278" mass="32275" checksum="B5C28056E6CAC0CF" modified="2024-05-29" version="1" fragment="single">MRLLERDDTGGVRLTEDLPNNKIPPYAILSHTWGPEEVLFGDMRDGTGKNKASYAKIRFCGDQAWRDGLKFFWVDTCCIDKSDSAELQHALNSMFHWYRSAVKCYVYLADVSTHQHGDGPGWQPAFRESRWFSRGWTLQELIAPTIVEFFSKEGERLGDKESLEQEIHDITGIPRKAFQGVPLSDFSVAERMRWIEKRDTTREEDKVYSLFGIFDVHMPVLYGEGRQKALKRLQDKVHEDYLCLAKLWPTDPRDPHVEKERIELAKGGLLADAYRWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGC1</accession>
    <name>A0AAE0JGC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl CoA binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_199295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681817.1">
        <property type="nucleotide sequence ID" value="XM_062821757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGC1"/>
    <dbReference type="GeneID" id="87858911"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3345204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="323" mass="36897" checksum="337224DE133202C1" modified="2024-05-29" version="1">MADSIDRVFVHALNTVKKIPKTGAARPPPGDRMRLYGLYKQAMEGDVDGVMERPSAATAYGAAPEDIAREQDKWDAWNSQKGLSRTEAKRRYVEALIETMHRYANNTPNALELVAELEFVWNQVKNNSPSEQSLAGGGLQQQQQHPQYNNGGNGGNYGYGSVGPYGQSPGTGVRRFQHPLSGAEGGLRVLSPMSEEDESERRVREEAEQELLGGDEFPGEYAKRNDKRTKRMERVIVRLSAEIAALREQISSGREWKTRKEKSFTNWLGWWFWVLVKHFVIDLFILVVLLIWMRKRKDRRLEDYVRGTLKLAREYARMILPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGK4</accession>
    <name>A0AAE0JGK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RPAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_490555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682542.1">
        <property type="nucleotide sequence ID" value="XM_062827731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGK4"/>
    <dbReference type="GeneID" id="87864885"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="348"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3347460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="488" mass="53282" checksum="7212B11D204CA323" modified="2024-05-29" version="1">MDGTLEILDVKERAVGEVKPPSFPTPPSASSGGFPAPKKRVSAFKKQRQQQADPSSSSSQATSSTPSPSIKFTSGAKPQIDADPIKSEKQRIDEENNKLLSSMSPEEIAEAQRELFNGLDPRLIQMLLRRANVEDGSNNNDPKVWDIPEKPAEEPTEKKADDSGPRISYKKPPSIKTSTSKSAYVEDEQEEETKETEQPKKPKKTVTFNEDLAPEQPPPGSFPIRTKQPPTPYPQKTCFSAEDLATPTFPTAGSSSEPQTPTTPCSDPSHNHSDEELKGVHFPAAPAPPDLDPSDPDFLSTLHQKFFPSLPADPSKLAWMAPLPTEDSPADQESPYYPGQSSLPVSALRFDFKGSLIPPRLSRQIPVSKGLHHHGEAPEAAGYTIPELARLARSSVNSQRCIAFRTLGRMLYRLGKGEWGTGAGGRDGEGDDLAFALWRCFQEGRVLESIGEAAGVEEGVGSVSVRAYAIEAMWLFEKGGWKEKWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGS1</accession>
    <name>A0AAE0JGS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RecQ mediated genome instability protein 1-like N-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_521326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682448.1">
        <property type="nucleotide sequence ID" value="XM_062828746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGS1"/>
    <dbReference type="GeneID" id="87865900"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="2">
        <location>
            <begin position="93"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31255" checksum="02295CF5488D0961" modified="2024-05-29" version="1">METARTLHRQLTTDFPTTSLPIPSLSWLTTLIPSNISRTPPLPSLLATARSRLLSSDLCTPGLLDANWVPSHCFPGSLTGQSLPGAVGYVNSQEQILDRDVVVQVLDVENLNRSKWEVVEELEAIERGEQTRGREVIRLPTSNNTDGDGEGEGEGIDMGDGGTQTQTAAFAQNSTAQQQAAQQAARERKNATHKLTLQDSSGQRLYALELKRVEEISVPQSVNGKMIGGTPIGCKLVLKRGTKVARGVVLLEPSMVKVLGGKVESWGRVWERGRLERLRGEVSQQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGS6</accession>
    <name>A0AAE0JGS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_147425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682438.1">
        <property type="nucleotide sequence ID" value="XM_062821024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGS6"/>
    <dbReference type="GeneID" id="87858178"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="12">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="279"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="751"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3347356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="785" mass="85781" checksum="D0F4678B4CE13DFA" modified="2024-05-29" version="1">MTANSKEGNSKEEPGHAPLSVANAASNGPPDAPPPAYQSHPLGPLSASEITQSSSLIKASWPEGTECHFKIITLLEPAKAELMPYLVAERAGKTPLDIDRRAFVVYSFRGTHNVHEAVVNLTKNTVESNAKLGPFQHANSDGEEIMAVEKTLLAHPEVQAEIAKLKLPEGTQIVIDPWIYGADGVKDESGKFYDDLRVMQCFLYMRDPNNSSEPDSCHYSFPLPISPVIDPATLEVIRVDILPTGLDEKVKPLEPWQSRPPNEYIPEAQASLRTDLKPLQVVQPEGVSFSVEPFSDMGRLIRWQKWDFKVGFNQREGMVLYDVHYDNKPLFYRLSLSDMAIPYSDPRHPFHRKAAFDLGDAGAGIMANNLKLGCDCLGSIYYISGVLADGSGSPVNMPNVICVHEQDAGIGWKHTNYRTNRAVVTRQRELVLQTILTVSNYEYILSFVFNTSADLAYEARATGILSTQPVDLSLSHTPHPYGTIVHPGVLAGYHQHFFSLRIDPMLSTSSTPLLSPSTGPRNSIVYEECNPLPFDPSNPSANSQNPHGTGYTLATTPILESGGYDLSPSTGRVFKILSPSSHNPVNNSPAGYKLHIPPMQPILAHPSSFHHKRAEFADHSVYVTKYREGELYAGGKYTNQSRGGTGVRSWAERKDRLEETGDDPVVWVQFGLQHVPRTEDFPVMPVETTRVVMRPANFFEKNPALDVGESRQEVNCSVGLSEKMLAQAGKVGGVVGEKVKELGEKLLGVNLGGEGSKAEGESSGKDKKVVGGEGGKLAPCCGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGZ9</accession>
    <name>A0AAE0JGZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pal1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_152850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682764.1">
        <property type="nucleotide sequence ID" value="XM_062821103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGZ9"/>
    <dbReference type="GeneID" id="87858257"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042021139" description="Pal1-domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30522" checksum="FCEE4A03606DF2C7" modified="2024-05-29" version="1">MHHPLSLRFLANLTVTILLASNLVSAFHVGDLLHTLRSLKDAPAGSVALNARSSNLTAPATVSNGTTGSSHPDSTEAKEGRLGLGGLLHNIFDRHDKPSTSTTLNIRGSNGTVTPAGVSNGTTPSGVSHPDSKTEGDHGFLGLGGLLHKIFNRDATPITITTLNIRGSNGTVTPAGVSNGTVFTSSSHPDAATDKGQGLGLGGLLNKIFGRSNPVPVPVEPEDVDEVDGEVGMLMSLNRRAERDGEKRLSREERRKNREKRRVRRAMSAATEAEKEERHVARSRAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHE7</accession>
    <name>A0AAE0JHE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_154178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682813.1">
        <property type="nucleotide sequence ID" value="XM_062821124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHE7"/>
    <dbReference type="GeneID" id="87858278"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="229"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="707" mass="77311" checksum="9D24BCA7096AD881" modified="2024-05-29" version="1">MGTRFRIVCNLCQAIIPPVEQDLNNDDGPIPRLEWNQEARAVRTVRDTSSPFLTGVGYLTRWGVLQASHNPDVPYGTDTGLLNLGARNDAILGQSGNGQANHPKYLTFVFHDACWQLFLAGILPGLPDSVTACRTPQEQVGLVAEALFRYLSCMPLTKLNQVVVPHDLPPYRAADLVLPRDYAPTDRAIMMADPSDLPTLDGSPQVVDHQHNDHLYTINPNFHSASSTDTPFSTLPEELIHQILNLLPSPDVCNLRLASRSVASVSSPLQLPRSFWASRFECGNEMGFFYPGRPFPDTKPPTDYRQLHSTLRLELSKVTEVMNLRNRRRIWRMLREMSCCITLAIEHIWSSTNGDSDTGTPFVQIPEGHVAGRLVCPLPLRGGPVTKALERSAGTTIFAGQAAIFPDPSLQAPMCVGVSFLRVDQRPYVCGIRVLSARSDQACRVGVIIQESETIVALKADDELSGFRVACLANGVVGLGLLVRPVSNPECVPMLHPFTVGNLDTSTSGLGLADVTPTGGGLPTGIIAGLDAACRIVSLQSLECQSSVCKEEEDISTGPFAKKATQPRSQAVLWSPSIPQNEQDILTPKTKPGIHGSVAVREDQGSDFVLNIPFGGERGERLKTLNRIVAYTDPYSAYGAFKGFGFHYDDEPAGVFYGTRKEYDSFPIAFRQCLQSSFTINGKGGEVIDHIELFGLVSQWYKLDAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI26</accession>
    <name>A0AAE0JI26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_152129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682717.1">
        <property type="nucleotide sequence ID" value="XM_062821088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI26"/>
    <dbReference type="GeneID" id="87858242"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000181">
        <property type="entry name" value="CALML5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000251">
        <property type="entry name" value="Calmodulin-related protein 97A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3347635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="150" mass="16865" checksum="79DFA5DDF0CEE4FE" modified="2024-05-29" version="1">MSPKYPTLTPDQIAQFREVFDLFDKDHTGDITAEELGVVMRELGLNPSKSELEDLVNEADMNKDGVINFEEFLNLMSQSVKETDTEKELLEAFKVFDKDGSGTISTEELRAVLKSLGEDMTDADVDEMIKLADKNGDGQIDYTEFAQIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JID3</accession>
    <name>A0AAE0JID3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_174834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683487.1">
        <property type="nucleotide sequence ID" value="XM_062821422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JID3"/>
    <dbReference type="GeneID" id="87858576"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="253" mass="29060" checksum="CBDE416DDE9D75BB" modified="2024-05-29" version="1">MEAALQSSPYWKMTLLSEQQVCVAALFLPPPVLRHLQARTVEDEERERRTRSLARLVSVSRNGLGKLSHPLSPLAPPHFLTKVPRSVPPLGPYHLEVQHHLSLHRRHRLGHSALLRLRRLPDQLHQLCALHRRRPGLSLHPIFLVHRRRAEPKYALAALLSWMIFTKTIKVFRYFSAKSQATRGLVENYSILPRSTFFNSTFPWDLFCCCGHFHFPTKTNQTPRFTSFAPSNLYPGFARIMDDLSAIGNGRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIF2</accession>
    <name>A0AAE0JIF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_462847</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683323.1">
        <property type="nucleotide sequence ID" value="XM_062826660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIF2"/>
    <dbReference type="GeneID" id="87863814"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="415"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="704"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="775"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="704"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3348241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="833" mass="89139" checksum="86DB37BB61463AD5" modified="2024-05-29" version="1">MSSTEQATPQGPRGDGNRGKGRGRGAPRGNRSRGGDGAGRGGAGAGRGKGRGGGQQQQQGAPTALQDSSSGDSNPAQWKTQQQEAQDDDDEVCFICANTITHHSVAPCGHSTCHICALRLRALYKTKECPHCRTAAPFVIFTDDPNKRFEEYTSKEITSTDDNIGIKYAGEEIVGDTVLLLRYNCPGGECDFAGLGWPDLHRHVRSVHHKKLCDLCTRNKKVFTHEHEMFTDKELRDHMSRGDDKPGAVDQTGFKGHPLCGFCGERFYDNDKLYEHCRSKHERCFICDRRDSRQPHYYLNYDALEKHFKQDHFICQERDCLEKKFVVFDSELDLKAHQLSEHGNSLSKDVRRDARVVDISGFEFRSSYQEERGGRGRGGRDGRGARGRDPNAEALPVSTAQPLRRDELAFQRQMAIAQSASSARPSAGPSSGTRPAGQTSVIQSRPSRPQQQREQQQQQQPIIDAMQNLSVTELSSLTPEQRASLTRHGAVIERASNLLGNDTAKINQFRSYISNFNKGSMTADQLIDAFFSLFSETSSNALGTLVREVSDLFDDKNKGASLHRAWQNHRVINEDYPSLPGLGGMHGATTASSGWAAAASATPVTLHSNGGLANAQSRHSNHVLKLKNSTRIGSASERGLERTVASLQAGGSSSSSSSRLVPGTNAYAAHVRPTVNNSAAFPALPGAKKPATTSGLSGFTAAAAAGSSSSSSRPVAAPASSSRPSGGSTATTIARKVAGGSGSMQKPGNEDAFPALPAAPKPTTTLFGYGRGAVRRDFGQPKETGFNWNAGSGSGGASGSSSAQQAGGEGDADGAGSGKGKKKQKKQVLVQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIJ0</accession>
    <name>A0AAE0JIJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G protein gamma domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_178794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683640.1">
        <property type="nucleotide sequence ID" value="XM_062821479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIJ0"/>
    <dbReference type="GeneID" id="87858633"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131655" checksum="96C94F5480AE870B" modified="2024-05-29" version="1">MSPSNSLDFASLFHGVPPLPPPPPPIPNPTGRRRRKGKEQLLAGKRFWADPPKPTTTLPAKAPQVQDEVAVAQIRKDERFDRTNLKARVRKLLVVDDKAEDARPRKPTLNVFAVVKKPAGRASKPANKQRPKAVKQDPSYRPDKWSSSESEEDSDWDFVPGDLPAFGQVKGQEQFSPVTTSSLTCVSPQRPTRPPPPPPIPNPLKRKRIEDPTYRPSRNSEESSFDDDDEEDDGSDEGVEALKRLKLGKNNKKVKKRGGRVAERQREKSPEKDKRDMLTKGNGDEMQKPINKKGKSVWDPSYKPPRDEEDDSDEYSDEYTSTDGGSRQRRKKVRVRERGDGPKDKNDDNAHLDDNPKNDVIPQEKLLPCQARPCLPPKFGRRKIKQRNRHKPPRIYDPSYKPGTTSTDDDSNNTDSSWSSSEEGKDRKKRKNPQPKAPKTLQTVSDLQHEVIRLMLKETKSASAMTKKRKRPRILRRHTSDQSFRPSDTTSDEYSDEWYSSEYSSSELDVKNKKRKKGMKKKKDQPNVNRNSPGFGPVTGTREDLDCGSPVEASEETRESVKPEKQPASRKTGRRRIGTLAIDGTHKPSADSESSEFESEPISGLDHSVSSMKTSNDDPKPELIFEPKGQDSIPPVNLEGETPQVQTPSRPLSNIKTAFYPLCHGRYSPWPPARGTVYCQPCFREQVVVRGLLIRRGISETMRLLKVLLGGGSDFGKELDEALEKLLGGVETEQVRSTRVEDYGQGQDEEDEREERVQRGEDTHTKPMPSAQSSPSELPEDVQTLLVLRRLSDIVNTRSTPTLSTAYPSGSDVSPTMPFSLYFPSIANAASSKPSHQQQDPTGPSRYSSPLPPCPALIPQGEAHNRTGNGAGIKMSYFCLKPPSTRSIISLPSPNPLDNAINILHDAIGISTWQARRLWNQYEGSGIWDLAQVDSLVEKSHAKCLKNSDIEVGMGNDENHQAVMLELESLAQLEEEIRNAFAEKGSREEENEGRTRQSDGGGTGATRSIMFGAVTAGQAGRKRSREDDDDDCRLGRDHAQPPNKKCKLIKPIDLLKSQEAMPDSPQTPREKPRMIPCHSCSGFNTANYNSCAAVRRNDYIEMGGRPWVKTLQWTLDINESEAAKMTLNSFLDLISRSGKAAHVNSSGWEFVVHRPGDDNDAETRVVFLDVRPGLDLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIJ3</accession>
    <name>A0AAE0JIJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_175277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683504.1">
        <property type="nucleotide sequence ID" value="XM_062821431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIJ3"/>
    <dbReference type="GeneID" id="87858585"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="143" mass="16219" checksum="B7D9118E39698542" modified="2024-05-29" version="1">MTPPCQSFKAKALPQHVQVGPDHRVRKTENGRRIDLLRDCELFGLLQYDCQVRDPELRESQIECWPVQRLFRRCQDKNGPFTVETTTWEGTAAAAAAAAASSSSSSLAKATSATSNKSSLAEQVDHRTWGREDDKEDRWWNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIL4</accession>
    <name>A0AAE0JIL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_170059</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683321.1">
        <property type="nucleotide sequence ID" value="XM_062821352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIL4"/>
    <dbReference type="GeneID" id="87858506"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042089309" description="laccase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="85"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="211"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="432"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3348239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="596" mass="66046" checksum="2E166CBA5F3F7F53" modified="2024-05-29" version="1">MKSALGCVLSALVASVCASSLRSLRHSPLHALRQTPPQLDYNLLPRAACDNTNKSRHCWGNYSIDTNYYDEGPDTGVTREYWLSIEEGPCEPDGYARQCQTVNGTVPGPTIIADWGDSLIIHVTNNLQSNGTAIHWHGLRQSGSNIYDGVPGITQCAIAIGQSMTYQFKVSQYGSTWYHSHFSLQYANGVFGGMIFHGPATSNYDEDLGHLFLSDWSHVDVFTRWFAARNGQPPALESGLINGTNKYDCSNSTTDPNCTGRGVKLTTVVEKGKKYRLRLVNAAIDGVFQFSIDKHKLKVIAADLVPIKPYSTSSLKLTEGQRYDVIFHANQAVDNYWIRAGWLNSCQPNEHPDSITSVLRYNVSSTLDPTTTSDVTLSTDCLDEPLSSLVPHLKIDVTNIQKSFDTYLNISKTNYVHWTINTSSLIIDWANPTLKQVFNGESLFPTDYNVLAVNKNTNDSEWIVLVIQDQSNLGLEHPIHLHGHDFWILDQSTGTFDASTSPNNFKTKNPPRRDVAALPGNGYLAIAFMPDNPGAWLCHCHIAWHASEGLSLEFLEREADIQADVSNSDLTQFNDICGNWSNSLGSQSFQQEDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIM1</accession>
    <name>A0AAE0JIM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VIT family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_178212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683622.1">
        <property type="nucleotide sequence ID" value="XM_062821473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIM1"/>
    <dbReference type="GeneID" id="87858627"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3348540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="302" mass="32734" checksum="039FD46A1F747098" modified="2024-05-29" version="1">MTTSPETSPLLGPRPTRTDLPPSEYEPHKSRPSSIRSMRSCLTSSSVTAAGPCPRQQPPSGCDSASSSSSKKSNTFDGLFRDIILGFSDGLTVPFALTAGLSTLGSTKLVIMGGLAELFSGMISMGLGAYLAGVTERQHWEAEHARKAWEVSNLPQLEQSEILSILEDDYGVSRVTAAALVQDLCRKGNEENLVRFLMDLQLRMMEPDLNRAWVSAGVMGLSYFVGGLIPMVPYFFMERAREALWVSVVITALILLGFGFVKNWVTIRTREAGVWGAVQTLVIGALAAGTSYAIVRLLDSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIU9</accession>
    <name>A0AAE0JIU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_567075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683770.1">
        <property type="nucleotide sequence ID" value="XM_062830346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIU9"/>
    <dbReference type="GeneID" id="87867500"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3350475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="232" mass="25764" checksum="6004AB98ACE67377" modified="2024-05-29" version="1">MKYLLDPLKVKRQLEQQGYFIPVFEFAETLHNIAFAAMGKDLPSDEVLRHSQKALDLISQVDGHTNDHTRFLFCRGLALYFAHRNAEALAVFEGVYQTCTGTFGALSSQARDAGYAVGFLLYTMGRPSEAQAFVEGCLIRGKEQAGLLWPKECRTRAKYLYSLILLALGNIGSGDRLRDEAIRELKGHLVAAFPGTLPTELNAALSFTDDLVGFEVFGSVVPFFAGRFDVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJF8</accession>
    <name>A0AAE0JJF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Manganese lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_96188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate</text>
            <dbReference type="Rhea" id="RHEA:18993"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:57467"/>
            <dbReference type="EC" id="1.13.11.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.45" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683984.1">
        <property type="nucleotide sequence ID" value="XM_062831616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJF8"/>
    <dbReference type="GeneID" id="87868770"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="9">
        <location>
            <begin position="270"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3350689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="755" mass="85291" checksum="DB7F3DDFF525F915" modified="2024-05-29" version="1">MAISRPKRSLARRAVAFVKKLIHKHPIPDPSLPVPTATQAASQPDKKTILKHPAKKDFLKQIVPETIGDCPLPSFDPGIFHSELLDLKLYPKVDPNDPKNIKEPEGNVREGTYLGTHLALTQAYERVEQTFNSLFDVLGIEPTFPRYVSLEQQRKIYQFTPYPNNADGTPAEFPPHLQHIPVDQNHTVFGVFNNAGLLETAVILQKLIPDEDGFLGRTKQWLLEKARAAAYGGEPEKGITIQDVEDYNRFHRKIGTDIANGGNIGLLDDWYSDRRFAEQQFTGTNPTTITQAGKQWIGEFLTAARIGGYNEWISALEAADPASFFVQDGSYFRNAVGVSDSSAVLHHKQPGSDDNWCVGAVSLFQLHDDGKLHPVAICIDYRGTMEQSVTLFNKRLTPRDSTRTEKTDWPWRYAKTCAQVTDWMRHELTVHLTLAHLVEEAIIVGTNRSLPMEHPVYRLLSPHWYKTLSVNAAARATLVPQVIVDIVGISPEQCHSFIRHAYDTYDFVAHYVPNDLARRGFPNTAEGLSSSTRYRNYAYAKDVLALWTVLRSYVSEMLALSYPSDESVAQDRYIQSWCTEMRQGGAHMSSFPEIKNLNSLTDAITMCIHTATSFHSAVNYLQNFYQAFVIAKPPMLCTAPPTSLSVLQQFKEHDLVASLPINRQRQWLLSAQVPWLLSFRAPQDRSLLNYAASMWRVYKTKKGRREKMVAEASERLYARLRETQTTVWENSRAMEKGSLPYMVLDPGNTAVSILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK21</accession>
    <name>A0AAE0JK21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_506574</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684402.1">
        <property type="nucleotide sequence ID" value="XM_062828070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK21"/>
    <dbReference type="GeneID" id="87865224"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3351107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="503" mass="54649" checksum="749EDCCA112CACCD" modified="2024-05-29" version="1">MSDLGVPTIPTNYTFSPSDGTPYLTINHDVAADLDSTNAFEGPEKLLEVWFAPSAKALPAGVKEGGLKAVNPDSWTPMLDLVHCKVLSIINSENVDAYLLSESSMFVFPHKIILKTCGTTTLLLGLDLMLRIAAAEAGFPFHNVASLDDPKVAATPLRVFYSRKNFLFPHKQRGPHKSWRDEVTFLDSMFENGSAYMVGKMNGDHWYLYITSPTSSLTPPRTPTSSRGVSPSRRSKIPTGIVAPFGGVIENNADETLEILMTDLDPENAKKFYLDEATAIAKEKLFAKSEANGDASFDVFSSSGDCDADGQAVLPEALTTEGHALGTVVSEACGLSAVYPTSTYPDARIDAYQFSPCGFSANGVVPAVAGADGTVPKAGHYFTVHVTPEPQCSFASFETNVPGGQNGRQTAEVIEQVVNIFRPGRFSVTLFEAKGALATTPGEDADDSRRSWGAAAKQRMERINGYRRVDRIVHDFEDYDLVFRYYEREDWVGGGGARMGEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKG8</accession>
    <name>A0AAE0JKG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_419067</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684705.1">
        <property type="nucleotide sequence ID" value="XM_062824179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKG8"/>
    <dbReference type="GeneID" id="87861333"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="233"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="435"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3351410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="698" mass="72831" checksum="BE8E41405B728334" modified="2024-05-29" version="1">MADQLSSGMGNLSIDQPPSGPQMGGQGQMRRSYIPPHLRGKMGEAAPPMAGPPAGVNGLNNSAWAGNNTYDARGPGGGNWPAPGGPGGPGGPPGPGFEGQQGAGWGGPRPQGGFNPNAYRGNAGAGAGAGAGAGGGNFSNRGSGDGQWRDGKHIPGPANPRVERELFGTPDDPSKQHTGINFEKYDDIPVEASGDNVPEPVLTFSNPPLDNHLISNIQLARYNVPTPVQKYSIPIVMGGRDLMACAQTGSGKTGGFLFPILSQSFHTGPSPIPASAAGAYGRQRKAYPTALILAPTRELVSQIYDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLCNIKYLVLDEADRMLDMGFEPQIRRIVEGEDMPKVDQRQTLMFSATFPRDIQILARDFLKDYIFLSVGRVGSTSENITQKVEYVEDIDKRSVLLDILHTHAGGLTLIFVETKRMADSLSDFLINQNFPATSIHGDRTQRERERALEMFRNGRCPILVATAVAARGLDIPNVTHVINYDLPTDIDDYVHRIGRTGRAGNTGIATAFFNRGNRGVVRELLELLKEANQEVPAFLETIARESSFGGGRGGRGGGRGGGRGRTQTADYRKFGGSGGGGGFGGGFGGAPASGGYGGGGYGGGAPPAGGYSGGGGAGYGGGGGGGGGYGGGGYGNPGGAGGQSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKX7</accession>
    <name>A0AAE0JKX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_568754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684835.1">
        <property type="nucleotide sequence ID" value="XM_062830402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87867556"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="152"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1402"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1402"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1415"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1439"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1480" mass="163569" checksum="68482797AAFD3C34" modified="2024-05-29" version="1">MSKRKTRDLEPQVVSPKMAPTTSRKSSQESSNAAAGGHVSLAEPFAVNHQDRNNDDAVAAHESWRRKLHKNARRAAERVGLSRLKSNRSQRTANKSAPSDPPLTPLRRSSRVPAPNKDTPNKDTTDKVMPRGRRGKSTKAKKPKKESSETFYSVRRIAGEKTEKGRLFYLIDWANDPVTGKSYDPTWEPAEYVTEAAVAHWELTKDKAPQSDDDTEQENKGQDEEDEEDELPIVHRRQKRKLSLDREEEQQPQKRARTAGTQEDNTGANPRVKPVKIAVEIPREPTVDPSDFVPVIVSSQDSSQPASQHQEPAASKEISQRTIPDSQAVGDSLPSLLQETQKEPDLLPEDEVSDYHSAVEDPDSEGAAIPSSSFASAQAQSTQSGAVIPSRQIEDHLEVEPQSIISFDDQQTAAEKASPQQDLDSNLSSSPPGRFLTQLDFDWLLAETSLSTSGVIVSTSQIVSQNPDNRSQGPANDKPDTTTTTHTSPQTSNSAPSQAAQVLLPSSSISQQLRSQIEFTSLIENSTQSERAAHHSQTDNDIVPATLQKEVSGTKESPSGIRESPASPHMILRTLDLNQPTKQPHSDNTNRIDNPNTPPRSSSLSTPHTPNQNEDCETANFRMDDAFPTETPQLSATETLQRLRDQIYGKQSDEPSTLLTSPASHLDLHTTQPEQQEQQPAVISPVDVFPAPHPDPADPWEIQPSGNILHSIDPSPGLHPGSVISNGETISAVEQLRRSLGLPFTPNAPHTELDISPEPVETHDHVASDEMPATIAPSELDVSTGHDALPSHEHVDFEQNNDDMSHTSRNIDSEEPEEESDLTEFLVTLPMAANSRPQYLETIDKNKAAMEEFCQAFSESHPAMPNDSLTAKIDSLFQRLADLCDLPAYADTIPAMTPTEMMKHATGTNTKFSFIYEFLHLARDLNLRVLILCRPGRTFDYLEAVVSTPGFNYNVLGRDEPTPSDEASDGLWVVLASPDQDLSAVRGPIDVAIKYDHETRSTRLPPGLVPVVLSLVVSYSLEHVDLQLNQMEHGLSGLEKKNALTLAIDTPTARRLFVSPPDEGHEPHKAAELFACFLQNPDNDLSWDPQVLPADVFDGWLSSQNRMESAQHVLPSRDATGRKRHLDVVDAGTPKRARLSQTQTPRNSTPSQMTDLLRSTLEKYPGRPATQFMEVSVEQLEALAFKIFELESDLEREASDENRTRLLARNLGVELASYKRTVEVLQPKYTEALHDRSTFEKTCKKAVDENVAAQKRLEASKHDLDTAKAEIKASEAKLAAANSQLANSSNPDLSRLARAEKELEDTKTKLAALEKRLATTTNEMEYSRSAYQNASNAHTELNNENLALKRKIEELQRKADENVVRVNQINSDQEKKFLGKQNDEYRAMIRDRERELETARAELRHLKSGRRETRQASVPRSPRTTTGIMSPRTTVGRRNANTDTAASSRGNSPAPGNASDGNGNGGGGMNFNPRWGHLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL12</accession>
    <name>A0AAE0JL12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_115101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684641.1">
        <property type="nucleotide sequence ID" value="XM_062820641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL12"/>
    <dbReference type="GeneID" id="87857795"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="292" mass="32552" checksum="82841E3F4B0FD996" modified="2024-05-29" version="1">MPVTRLTPIKTLVPLSQSISLIQSLLPLISIEVSPIPSFYNTSTSEQDHEPFVLGKPYRESKSNHPAIDSGFFLPSAIISGSTGYPHHHASADLLDPTCWPFCPSVPAYTSRPRTYIPSDSHRRDLHLSERKANVQHPSIPSQHPGRAPRQVATSLGISRSTIPAAPFLPIIPLPLTTSRSTARLDLCQIVPDCVRLCQNSIDKRDQPASPHRFTSHPFACSWILISPWLPCFDPFGHTPAISTCRPIHRRPTQRSCPRPVIYIPPVRSRSKAQRHPPTLDLPSPRGFHLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLZ7</accession>
    <name>A0AAE0JLZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_440906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685404.1">
        <property type="nucleotide sequence ID" value="XM_062825489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLZ7"/>
    <dbReference type="GeneID" id="87862643"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="509" mass="57755" checksum="718AA80EB2DFB8CF" modified="2024-05-29" version="1">MSYPTPTRRLTATGAFSTQPNAQRFAATGKIYHNQTPLHNLHPYSGGNFYLNLPRNLQQYPAESQTINEAWNTNGQALIPNSNVPPGFIDHAQLNQSHLQQQHQWQQIPPVPVMPQPGPAVYSAPSVGLSQFQTQAQPQQPNWFFINEPKPDPYDFSLLSDFGPNTYASPEFVDLLTPQRAQVPEEEKCHTALPSSSSTEEVGLVYQAPPRSIPEFRPQYDASCGLINQLDPNIYASPKFVNPANTKPEQEPEVTKTHTRHSVNFVDFTSSPPPAYTATASVHHPRPRNYAAWGIIDQPEEDLSAFSDFLNHSNMKPEPESEEDEEEENEEDEDEEEQEEEQEEEQEEEQEEEQEYEEEEEYPTATAPPPTYTTTASTPKRPEQEEPELFDQGLLDNILGACEDTWQKKTKPAITAMLYKYKRTRIDRQQQQQQQQQETSSGQQRKHNWLGRNSGEIGEEHNDDAGLGETAGTERTAKPQEVHDGLPSRVNDQLRLSFRHSQPWDGEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM88</accession>
    <name>A0AAE0JM88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_418630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685141.1">
        <property type="nucleotide sequence ID" value="XM_062824154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM88"/>
    <dbReference type="GeneID" id="87861308"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000092">
        <property type="entry name" value="Aspartic endopeptidase (AP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="106"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3351846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="486" mass="53674" checksum="B979B1C242ECD5A3" modified="2024-05-29" version="1">MGSMYQVQSKLRQDLGLHKIQAVRKSGRELNGTKAYVSAMARYGFNPTEESRFFHLKKTDLTKEFQRRGYTRHWEQLVRAPQERPDDPHTENEPVPAEDQQYDTQYLCEIGIGTPPQKVKLDFDTGSADLWVRCRDSSLLHHADKKFDPKKSDTFQESKTDQTWKIQYGDGSTASGTVGTDVITVGGLQVKNQAIELAKKVSSAFSSGEADGLLGLAFSKINTIESDGKPDPQPTPVENMISQEDIPKEAELFTSAFYSARDDKSEEKSFYTFGWVDEDLVKASGIDIAWTPIDNSEGFWKFPSESATVDGENVSVSGNTAIADTGTTLALVSDTVCKALYAKIPGSKYSYQYQGYLIPSTITTDQLPQLSVAVGGSQFIIQKEDLLLAPADNDHWYGGVQSRGTMPFDILGDIFLKSIYAIWDQGNNRFGAVPKIEVNQHTVFPTTESSTEASSPSPEPAAPIGEVYLLPSLEQVRDAVANLQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JML5</accession>
    <name>A0AAE0JML5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family group 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_132849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685042.1">
        <property type="nucleotide sequence ID" value="XM_062820832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JML5"/>
    <dbReference type="GeneID" id="87857986"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="758"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="891"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="93"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="567"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="948" mass="105792" checksum="329C6730C7D651CD" modified="2024-05-29" version="1">MAGSHNGGKDFPLRPLPPSRNPSSTPSDFPSPLNSPLRSNFQHGPISGVDTPPSSELQGPQSFYNQTASGSALSVASDQTGISTPVTYADEFKFKTVIKYLGKHIEKAGWMPPEEERSQPNGYGVLYKKSRGQYVTYPETLSQAVVACVQRLNLVIAFTMKLDMLDAPNGILASLGPNQSELKLMDGSQLQIADSLDSMVPANVKKFQYACLVRQERILLVWHDDMLQIVPTAARIEAKLLAKVWGTGELPFGNLQAPSRPNSVLSTNTSIYKAEKPSTPGPGNMGALPNDSAEQLEKDESVDAKESLQRPVQRTSAFFVGMAMCLGIVLLFGTYISQLLIECVVDGTYTRLALIVCVPFLLCVSLFFFQVIFSNLFQIVGPIGGQHTNSRFYSCIKPSLRRAYMDGFTAPHITIQMPVYKEGMESVIIPTVRSLQAAISFYESHGGSASIFINDDGLRVLSEEEAQKRIEFYHDNHIGWVARPKHGDDGFVRKGKFKKASNMNFALNISQKVEKYLQEMVDAKFAAEGTDLVDEQEEEEMYQAALARVLEENPLAQAAGNIRMGEYILIVDSDTRVPVDCLLYGAAEMFLSPEVAIVQHSTGVMQVSWDYFENGITFFTNLVYTAIRFSIGSGEVAPFVGHNAFLRWQAVQDVGVPEPNDYTAYWSESHVSEDFDIALRLQIKGSIVRIASYHGTQFQEGVSLTIYDEIARWQKYAYGVSEMIFHPLHRWIFKGPFTPLFYTFLGSNIMYSSKISIFAYICSYFALASALMLTLLNYFLVGWFVDTLDHAYMSSWQVFVSLVVVFNIMGHIALAALRYRTGDRSLLSSLCENFKWTPMLTVFFGGLSFHVTTALLAHLFHIDMQWGATSKEKENSNFFQEIPKILKTFKWMYVFVILVAAGMVYLGKWAPKGWEINDFTAIVPLAVNLVSHALTPLVLNPSLMVFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMN3</accession>
    <name>A0AAE0JMN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_447922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685675.1">
        <property type="nucleotide sequence ID" value="XM_062825879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMN3"/>
    <dbReference type="GeneID" id="87863033"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000033">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40144" checksum="63CC3AEB2C3E6A51" modified="2024-05-29" version="1">MAPIAQAVTVSLNDLKNGTVSLEALEEAFGPDSLGILVVKDVPAEFAELRHRLLSYSSYLGNLPKSELDRLENETAKYLTGWSLGKETLKNGQVDNLKGSYYANCAFYVDPSLSCAKPTEEFNPDNFPEYLSPNMWPEESTLPGFKPTFEDLCRLIIDVAVLVARACDRFAEKQIAGYPAGYLEGVVKTSTTTKARLLHYFPEDATATDANKEDSKEEGDEDDWCATHLDHGCLTGLTSAMFVDEAATPPVVNPSANGSLPPLGELPTSPDPKAGLYIKSRTGQTVQVKIPRDCIAFQTGEALERITGGKFKAVPHFVRGARAEMSAGRIARNTLAVFTQPNLGDEVDMEQHITFGEFARGIVAKNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMS1</accession>
    <name>A0AAE0JMS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Eukaryotic mitochondrial regulator protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_13842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685844.1">
        <property type="nucleotide sequence ID" value="XM_062820900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMS1"/>
    <dbReference type="GeneID" id="87858054"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="348" mass="39268" checksum="2E690EF2FAAEBC08" modified="2024-05-29" version="1">MPPRIPNAPSSLLLQSSACSGSSSRCTASRLPTWASSCSSSSPQSSQPTTHQQQCSSFSTTAPALVQSVRRQKMFAWLDKKGSQYKEHTRQGPNLLGSKGRDGLDVPFPNNPYFKSQPVLSEGSREIIYKDVMELGLPIKAVSAKYNVDVRRVAAVIRLKEIEKRWIKEYKPLARPYARAVMKMLPQTVLGGPDQKPHESINDVYVHSYTTQQLFVPVSESREFTRQDAAKAFGDHILPVDKKLRVPELIEFQKDLLKEVPLQEANQKFLKATAASEARIAEAEAKRRQAAEDAITRVKTDRFEFRFQEFNAENVGHDGRDRNAVGWRYGVPFHDRKRSQVKIPTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMS7</accession>
    <name>A0AAE0JMS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_136385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685132.1">
        <property type="nucleotide sequence ID" value="XM_062820880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMS7"/>
    <dbReference type="GeneID" id="87858034"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="213"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="670" mass="74620" checksum="F383178E7A043590" modified="2024-05-29" version="1">MPAQTSFPSLAALRRLQTLNHVHAPLRRTGSGRITNGWTCASCRSQLSSSFSSSSSYNSTLARRSFSASSKRYSNQSSNGSSSSSSSNNTNGKTTNNGRRTVLLAAGGGVATAGLLAFGDDVKYTYEAVERTGRVASALAVCVNDYRKTLNAREKIEDAEEKQRLLRECHQRCADRTLEVLEKSGGIFIKLGQHLSAMNYLLPPEWTTTFIPLQDKCPVSSFESIERMFLQDTGTSLWDYFSEFSREPIGAASLAQVHLATIKETGQRVAVKVQHPSLQRWAPLDMRLTSTTFKTLKYFFPEYDLEWLSSEVEISLPKELDFTCEAENARRTSRHFSQHAPSLPLVIPDVLWAKKRLLVMACESGHRLDDLSYMDAHGIDRDEVSATLARIFNEMIFGEGAPLHCDPHGGNIAIRHNPSSRSNKAKTNFDIILYDHGLYRDIPLPLRRSYAKLWLAIIDGDIPKMKRYVYEVAGIGEDKFPLFASAITGRDFINVVSATDSGGVLKPKEASEQKSMSTALQEGLIVDLVQMLGQVPRIILLILKTNDLTRALDESLHTSQGPVRQFLILARYCMRTVFYEQLEKIREMSGGGGGRGSLWSRPGNVVLVVKAWWEMARVEIKLEVFELWLRVKRALGLGQGGFGQSVPVGRKGQRRLEVEVEREVEATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMV3</accession>
    <name>A0AAE0JMV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_415663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685780.1">
        <property type="nucleotide sequence ID" value="XM_062823998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMV3"/>
    <dbReference type="GeneID" id="87861152"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="320"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="397" mass="45096" checksum="8DD025C2EC292DE5" modified="2024-05-29" version="1">MFTNTISSRQKMMRRKKNVKKGIQFCLMVCGASGTGRTTFVNTLCGKEVLTHKDSDDPATAHVEEGVKIKPITVELELDEEGTRIALTIVDTPGFGDQIDNEASFSEIVGYLERQYDDILAEESRIKRNPRFRDNRVHAMLYFITPTGHGLRELDIELMRRLAPRVNVIPVIGRADTLTPAELAESKKLVMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEDIIEIGGRKVRARQYPWGLVEVENPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVEGGAGVDSSMNPEDLASQSVRLKEEQLRREEEKLREIEVKVQREINEKRQELLARESQLREIEARMQREVAANAAAQAGTPTTSHSHQEINGSPDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMW2</accession>
    <name>A0AAE0JMW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-glycosylation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_448895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685935.1">
        <property type="nucleotide sequence ID" value="XM_062825926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMW2"/>
    <dbReference type="GeneID" id="87863080"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="470" mass="50153" checksum="8954AD84A3550569" modified="2024-05-29" version="1">MRNRAKSSAQQRGATHTSNFDPTTVDRPKSRSNDSVSTHTHATATAPATTNGNGLVRRLPQLQQQHQIPGAPPPPLPPPPPPPPPYHLLDHHHPNTIEANSANVHNANNASHTTTTPKTTAATPTAATGAATPMTADMNHSSNKNVDKPPNMTAHSSLLQPRVAVALGVPKKWHFLLWLCRQSSTFPAIWWGLPSALRLLAMLHLIVFGGSPTTWQHIFARVVAAGVGRSGGATSAGGGGGDMMGCGSGIGTDGGAMMMGSPDFLSSGAGAGATGGSSSTTNSGGGNGNYNYSPVASATGFSDLSFEARLRLTETLLAIVWCGASAYLSFFFTDSLMSRWLVNYTPQATIVRLLTITTLNAYLTSQILYLTAGSQDPRLLLPAWVGISAMLTLLYHITQRKINIRKETSMSIRAFSVASFISMVALLAQVHSNRTDYPQIPLWTFVTKVWQEFVKVALKIMDYGTVARDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN96</accession>
    <name>A0AAE0JN96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_19409</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686005.1">
        <property type="nucleotide sequence ID" value="XM_062821684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN96"/>
    <dbReference type="GeneID" id="87858838"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="47"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3354627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="537" mass="56491" checksum="218F5CF50EC8EA93" modified="2024-05-29" version="1">MANNTTSTSTSTRSASATSSAAAHSVTSTSPPSSNGTNTLYHDGDIAFLILCTALVLLMIPGVGFFYSGLSRRKSALSLIFTSILACAVTSIQWFIWGFSLSFSRNVASSGFIGTLSNAFFIGILDQPLVENPHKIPDLLFALYQSLFSAIAVVLAAGAAAERGRLLPCAVFMFVWVTLVYDPVACWTWNPHGQGGWAYAMGVLDFAGGTPVHVVGGCASLAYSMVLGKRRGHGTHELNYRPHNVASVVIGTVFMWVGWFGFNAGSALAANLRAVVAAATTNLAACVGGITWCVLDWRLERKWSAVGFCSGVVAGLIAITPGSGYVPVWAAVPFGILGAGLANYGTKIKFLCNIDDALDTFAVHAVAGLVGNILTGIFASKDITHLDGVTNIDGGWLDHNWKQIIFQLAGSFAGGVYSFVMTALIVFALDHIPGLSLRVSEAAEVMGIDDSEIGEFAYDYVELMREVGIDGGGAGSIMDGVGETGSMFSNTQLRQQPQQVARSASPTAAAGATRVFTREDTKDSGVVFGGGQTSFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNW1</accession>
    <name>A0AAE0JNW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_449599</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686141.1">
        <property type="nucleotide sequence ID" value="XM_062825964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNW1"/>
    <dbReference type="GeneID" id="87863118"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="13">
        <location>
            <begin position="236"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="610"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3354763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="649" mass="71939" checksum="276D71A367431D9C" modified="2024-05-29" version="1">MASNQEDLQRRPVYLYDIDTDILNTIAPKSDADITAEPVDETAKQTTDTTAAEPTTSGSQASCSLCGLKFDNVQEQRSHLKTDFHHYNLKQKLNGLSPVTEAKFEELVNNLDESISGSDLSESEDEEEGQDKDTNMLSALLKKQANIAGKMAKEDGDDGENDGGKVRTSSGSQPLLWFSSPKLPENSYYSVYKAMFTPEELKKEEAIVDAIKSRQLAPITMGKPPKDANDIPPNYTGKHIFMCMIGGGHFAAMVVSLNPRKTKHGTTGPLNKEAVVLVHKTFHRYTTRRKQGGSQSANDNAKGAAHSAGANLRRYNEQALVEDVRGLLAEWKGLIDTSDLLFIRATGLTNRRTLFGPYDGQVLRANDPRIRGFPFMTRRATQNELMRAFIELTRLKVRQIVPEAAAPAVEPSKRPKSPKPAAASKPKLSEEQETLLLHTQQIQALVKRSKVPALLSYISTNDISLKEFRFFPADHHTPTPLHLAASQNSAPLVTNLLTRAGADPTVPNGDGRTAFELAGDRATRDAFRVARSELGEEAWDWEAAKVPVALSRDEALKRTEREKNEAKEKEDQRRKAEEERLKKEGPKVDATKSGKKAGGSVLAAAMKLTPQERREEEAKGLTPEMKMRLERERRARAAEERIRRLQGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNW8</accession>
    <name>A0AAE0JNW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_33677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686424.1">
        <property type="nucleotide sequence ID" value="XM_062823575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNW8"/>
    <dbReference type="GeneID" id="87860729"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="275" mass="30895" checksum="31B7143F9E38CE25" modified="2024-05-29" version="1">MDPNNGSIPSAEEVLASYHLPQVKPQWLNCNYGKHIVKGNFLTLSAKPKTVEMGEWIAHQVVDHWRMLITFIKLVHDREEDGSSICNSRKCPKMSAGASHSFTWLNSRLQPVEIPAYEYLSLVQRYISGKIDDGNLFPTDPAGVSFADNPTFCTPLPESGPDWIGKRSGFPQNFMETCQTIFRQMFRVYAHLYWSHFDDMFCLNLEKSMNSCFSHFILTATTLGLLKKTDLEPMQPLIDLWAALGTFPQGCKAYEIANISVGNLLIQKAGGPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPR3</accession>
    <name>A0AAE0JPR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_49714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686877.1">
        <property type="nucleotide sequence ID" value="XM_062827801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPR3"/>
    <dbReference type="GeneID" id="87864955"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042208064" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17790" checksum="9E1CE3A36ED846BF" modified="2024-05-29" version="1">MLTQYVGSGFSQLLCVSLSAVCLSAVRCCDSGPGTGISQQARASCHSHHPNATKKRRFTIPRISGFDIPVDRIVSPHDDGRTSSITPTLANLPTLLPTTYLTSKPAGQASSTYRAESLSLLEDWTGLGTGPSVAGTGYDGFRRELLPPGGIGRSFVFRLCHPPTKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ68</accession>
    <name>A0AAE0JQ68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_57406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687132.1">
        <property type="nucleotide sequence ID" value="XM_062830566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ68"/>
    <dbReference type="GeneID" id="87867720"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="428" mass="49095" checksum="3F2081CA634FA73F" modified="2024-05-29" version="1">MSDSNTRAYLFKFRGSDYVFCRMAGHGAEAQAQVVQKVSTGELLIRKVSRNRLDRSKCIEPNEFHLMEEYLSKPPRSPDIRPLIPKFYGYEKIPSKNGKFHLVSYWQLLNGGSVKDLILTKYMTFKHTKFNPDKRFPARLIARMLHQVFSSLQHLYTVYEKKPIFHKDLHPGNIWVHFPPSGDGELSDIPDFYLGDFGYAGWDFGFSPNHTATRDIDQVLEWARLMICINLPEDQRPPRNGVVPCPDDPHRGTIPGDAPMTAILSLYYDFCHELNRFKEENGWHIRKPSCPPPDLTSFIRRAEALEKKLTPSLTGFMLMTGLNESNDARVQKFMHDMKENAMTKARAQPFTMHGPLEKCLTPMVRNFPIKVHGPFYLAEMRVATGRWEAIDDVTYHRPGKTRGSGRGLRAISESPDEEGGETDSEPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRL3</accession>
    <name>A0AAE0JRL3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_70518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687565.1">
        <property type="nucleotide sequence ID" value="XM_062831298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRL3"/>
    <dbReference type="GeneID" id="87868452"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="97"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3356188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="583" mass="62267" checksum="CC58057CC6B40C61" modified="2024-05-29" version="1">MQRLTSRGLSASASAAGRRLASTSSRRASPLLLSSASKMSSPVKTASATAARRIHATANHLRPAAAALESTATSYPTTHDKIADVKDTPWFIDNKFVASSTTQYIDLHDPATNNLVTRVPQNTDEELKAAVDSAQKAFESWKNTSVLHRQAIMFKFVALIRENWDRLAASITLEQGKTFADAKGDVLRGLQVAEAACGAPELLKGELLEVAKDMETRTYREPLGVVAAICPFNFPAMIPLWCIPIATVTGNTLILKPSERDPGAAMILAELVQKAGFPEGVVNIVHGAHRTVNFILDEPAIKAISFVGGNKAGEYIFSRGSANGKRVQANLGAKNHAAVLPDCNKNQFLNAVVGAAFGAAGQRCMALSTLVMVGETKNWLPELAERAKALNVNGGFEEGADLGPVISPQSKERIESLIASAEQEGATILLDGRGFKPAKYPNGNWIAPTIISNVTPSMKCYREEIFGPVLVCLNVETLDEAIDLINSNEYGNGVAIFTRSGPTAETFRRRIEAGQVGINVPIPVPLPMFSFTGNKKSIAGGGASTFYGKPGVNFYTQLKTVTAHWAAQDAIGQKADVAMPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRS6</accession>
    <name>A0AAE0JRS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Centromere protein Cenp-K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_71319</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687600.1">
        <property type="nucleotide sequence ID" value="XM_062831314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRS6"/>
    <dbReference type="GeneID" id="87868468"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11802">
        <property type="entry name" value="CENP-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="123"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3356223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39481" checksum="FF027F6B909484B0" modified="2024-05-29" version="1">MEGIIEGSTTTGTTGSGGRVKDPVHEANLERTIRELKRMTAEAEATLNELKTSITQNGAPPPPLSPLSSMHLLTRAYTSLSESDPTPLLPFPDSVLPALLALRKTSQTITQTTAHLSSSSSLLDQQKRHLEDLKTEVREQNELQQALQARVEALRKGMEARKEMTPEELAKEELEKMQGERKQYDEETKKLVRELNWFIEEYLGPLLAAEEMGGPVVGDMMDLEVEDLEAGFNAKGKLKKARAKKTDEEEGDGGRQRRIDDIWGSVDNQQDGRQGKRKREERDEASAAGAEMRSLIEKLLNKSMDAGGDSSAAYVRIERETAAARFLVRSKLAVFHPRDATRLRLVDFGRELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJJ3</accession>
    <name>A0AAE0MJJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exocyst complex component Sec10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_333241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676983.1">
        <property type="nucleotide sequence ID" value="XM_062823538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJJ3"/>
    <dbReference type="GeneID" id="87860692"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="64"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="204"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="821"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3334817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="880" mass="97122" checksum="ABAF38CCF72CB34B" modified="2024-05-29" version="1">MERGGPGSTRSPGPGLFPKGPSFTIDDFSSKDFIVRDFVDSLADTAFPANRRSGPTSASTPFDPKPLIRTFENALSQLGALSEELQEKESELLSQVRRAEIQHDQTLDTLGRKLDQSMAQFEALDLTLNNPSAHSGSMNGHARPDGGGNIAVQIGEKLEELDRKRRKAQDANFLIQCWTEVSETGQLTSLEEIQRQGGAENKVRCAVIARQLMRISQRLDPFSWVTNGFRANGITNGATGVTRKHNTREALERFCEHLEQDLLKQFNNSYRRQNFDDMMECAKVLYDFHSGASVIAAFVNQHQFFIDRDVLITDEVTTDGEMWEQLADPDADPPGVEPSLQSLVDEVKIVMQEESFIIKRAFPYYETVLIKFIQRVFQQSIQQRLEMLLDKATTISSLAYLRSLHASRSYIGALVEDLKTHGLTEHPEPCSAQISQTLDQQLEELFVPYLLGNSYIDRERKSLDELYNSLLFKFTLYHSRRKKAPSGFMAAIAQQGTQLLASAKDAYMERLDSSDLTPTQQRMMLRVAGLQDNSTNKNEIEVSEEHGRLSVQNAKRMIVWLAESVRRTLEMGSGSETPKDINVLLNLLLTSMGQVYVETALDAALDTATSQENIKTEPDLSYLPHIKPAVTITNLMSRFITTVLIRLAESNTALRRSMEAQAKQAIEATERKTNAVLKSTMDVAVNWVAKILAGQKKTDYRPRDNDLEGFVDLQTPTCQAICTFLASKVAAQAALAIDGHNLELFSSELALAVHSLLFEHFKKFSVNATGGLMVTKDIAKYVSTMKEWPLTKEVQAIVELLTEVGYLFIIGPEALRERSKFLSSGSGGGGGGGEGGGGAAGGAAGGGGSGKKLQKADFKAFVQKREDAATPGIQGVLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJR1</accession>
    <name>A0AAE0MJR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_436245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676896.1">
        <property type="nucleotide sequence ID" value="XM_062825236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862390"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="218"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="935"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1310"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1243"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1315"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3334730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1329" mass="144638" checksum="7F5C357E9140D489" modified="2024-05-29" version="1" fragment="single">SNRYHYHDSRDKHQINYNDIYSPCDDVKEAAKTFDRNYNCNCIHDSSTNYTINIGGGDGGDGKNDKDQGEDKDQGGKEKRNTRLRDACRQSPLHCCLSSSTMPVVYPFDLRFAPSAALAPDRTLELEDGSVQVPGLCPGSAVCAHMPAGCCVDCADMTSQKMIPSGASSSRTGRTDKDGPRSSARIAPGSHSRLLLRLSGRLKCLFLLALQLLWVQSATAVLIPWVNCLDKSYQMDKPTRLQWVPLFVDASFDDQDDRHTLKLTMWGNVTGVASSGNITLPPPGSPDWNDTSKQDGKIVGVPEPFSANPKVTTLFTNINVLTYSEATERTDFCNQSLRNAHCPLGPVWEVNSTNREHLPYVTYTKDFYSSYAFSSFASKFSIVYGDSGNTQIGCLTATVTPDLGNLGWMLKFLPLIVLVFVGVATIFAAIFSPWGTSDVFHWTSNYGRDPDLLRLVTPGFGDCLQYIQFVVLTGGLTLNYPGFYQPIVSQGSWSALMFNQSFVSDSPGWISLRDGIYFTEGKYGLERLAHLVGVGEVEDIWAGMMVWLMVIIGAVFVLTQGAFLVKWLYRSVRQVPEEDLRHKNLPFTLGNVVRLVLNYFLLPIVALSTFQLVVATHSPAYTVALAVVTLVLIIGFAAWLLHLIATSRPRAFLFDDLPTVLLYGPLYNTYSDEAAAFALIPVFLSFLRGIAIGAVQPAGVAQVVLLAICEVIQILTLHAFRPFHSPTSMNAYHTLFSGLRLVSILMMVAFVPSLEVEEGPKGWVGYAILVVHAGVLVLGFFLNAVQTIVEVVARLLGAGGDDVRGQSRGGLSKIFGMRQLSRRMPRRAGGPIRHSQLSSAAMLDTDETFKTGYVMNGGHIRSESAGSMGLMTKHRRHSSSGLEDVSLNTAVRNLDHGSFTPTTPGEASTFSFAASAQPQGRSPSAFGMPTVDPYFRPPRRRTTNESAYSPDAKPGGSWTSADWSQKRLSQSGVPLNDTAEFDPQMSRSANPGPYMIAYPPRTDYTTREVDYYYGLRGERLNSDAPSRKLGTGPADPTGPMASAAGWLRNILGRSSKEKGKGFEVVRSARMPPAMRTGAVDYEDESPPEGIPVAMGVIRNGPIESDEEDNVRQANADRDTAARTAAEAVPLRAAEGTNDDVRDDTETYHDSEGLPTEPDLATVSQSSRAQTVTRRGNRTSNEDNGPSPLLSPPRRSSKRNSYHHTRNGSVSNTPPAQPVLESGPQQQNRPASSLAVSARLPFERTNSQKRLSSSSIGVSEDLSSADAYGGSRTGSGLNESYGFVNQGNVNRVEQGHEPDLLGSVAEVGIIGRDNSRGSSQTGNTSRYSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MM93</accession>
    <name>A0AAE0MM93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_435602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677267.1">
        <property type="nucleotide sequence ID" value="XM_062825201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MM93"/>
    <dbReference type="GeneID" id="87862355"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3337816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="713" mass="78159" checksum="030A8032B6D2F67E" modified="2024-05-29" version="1">MILLARKKTSTEAGWIVFAVIFSTFSSALIIFLCWWNTRGSSKKSSTQQQQSASSNSRTRSRRSVRYWYYYPEYFGYNNGSSESSEDHDASTATDYHLEQTPNYYIYPPPYPPCPDPPPPPPRPPRTPPHIAVYRTRPVNVMSFLDRTQRVREPPPVAEVTSPGGTSTPPPGDGSSSSSDSLPDEPAPDGDGPPPSAPSGGPRPDGSAPGSPDANPASVHSPKEEGSVISRQDVSEAQANFSRLMSVADSHIQHLASASEAGSHRQSSARHTPSVRYVKAWSKGSSKERRGSKVLSPHGGSPALSIRESPNPAPGNITPKPNSHASRQSSRPSIHSHPSSKLLSPSPPSSRAPSHRSLPASRSRRSSPPRSPTPPHHSQSRYIHSHSHSHFDGRPTSRQSSRSGSRVFSSRSSPPQSPTPPHHSPIPYSPSRHSRSNSYGRPTSRHSSRSGPRSRVSSMPPSPTVTDFASISSISHPPGSPRRSSVSPAYRSGGFRAALSPQQEEQHELKGSRRSSRYSRHSKSPSAVSVSVVELLSLEKDLDQDDQGKGEPMSLLGHDELEEHEEEHEERRGSEVLVQYEDEVPRSRRSVSRDSQQRRRMDLADDERKSVEMEHRHHDHHDEHDPESATLKPEPEHVPEDYYRSYSTAANLDPLPPSPNLSGHSSNLSPKSPYHPRKYIPIQVPKENRPHQASVCSISDSTDSGIGSRKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMK2</accession>
    <name>A0AAE0MMK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_477819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677567.1">
        <property type="nucleotide sequence ID" value="XM_062827451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMK2"/>
    <dbReference type="GeneID" id="87864605"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="347" mass="40872" checksum="9338C3659745A3E3" modified="2024-05-29" version="1">MSTTLCIPQTALAMELDFLSDPEDWSDFGQMDVNEDTSTPEEASALHEFVQAYNTPSALDAEETARKLMSLNEDRIPCDGDFDKGIRIAWLLYGVGIKMVQHQVAILVVADAVMALPRLDATPEQEVRFGEEKLERWRTLEDFWGICWNDRWDRYNEFRYGNGFCGYIRANAWVARHLVLHPPNIYYTTELNVAFSRMMLALEKDPWNYPGVREDDDVSIRSPKDYTITTLNTDVHVLVPFLVIAGDIMYRYTDREMMARRFAEAHQENHEHNTREYWQEFSSNRSERSLWKAEKKVDQYEWLTRERWAFWKKRLVWISEQTELLQRTRDEAIMLVQLMTEIEGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMY3</accession>
    <name>A0AAE0MMY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_478839</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677853.1">
        <property type="nucleotide sequence ID" value="XM_062827505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMY3"/>
    <dbReference type="GeneID" id="87864659"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="95"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="510"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="831"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="510"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="213"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3338402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="885" mass="99507" checksum="8FEEB9EB7607E59B" modified="2024-05-29" version="1">MSLFFLPSTRLRLPNLSIASGQSYLSSIANLSNMGRGGNFRKGRGGGRGGKRSRDDNRGGHQPYTRYPEVVKQNDRLERYYNDLLQLPEEEREQFWAALKRELPNSFRFCGSKGHALAVKNLLQTRYIPEITRITYDGAIVEPPKPVPWYPDGLAWWMTTPKNVVRKFPPFSAFQKFLVSETSVGNISRQEVVSMIPPLLMDLRPGMTVLDMCAAPGSKAAQLLEMIHRGEEARIRHVIKQFGGSVDEIKSADEDAARLEADPSDDGRATGMLIANDADYKRSHMLIHQLKRLSSPNMIVTNHDATMYPSLRIPNPEDPTKPNYLKFDRILADVPCSGDGTLRKNVNLWKDWAPAAALGLHLTQVRILVRALQMLKPGGRMVYSTCSMNPVENESVVAAAIERCGGPDKIEIVNCADQLPLLQRKPGMRKWQIMDKSGRVWNSWQEVEDHAKSTEDGITPSRLVESMFPRPEGNICADLPLERCMRVYAHQQDTGGFFITVLHKKAEFKAKPEEIRPKEKKQAPKRPLEEAESTEEAKKQKTEADEAAKTEDVVIEEAPVEPVEEVKAEEVAPVEETPATEEPAVKEEAAETPAETPAETPKEAPKEGEAQPERKQKQQGPYEEPFKYLPADHEVIKNIADFYKISSRFPSDRYMIRNATGEPAKAIYYTSALVRDILVMNEGRGVKFIHGGVKMYVKQDAPSAEVCRWRIQSEGMPILHGYVGPERVVVLKKKETLKKLLIEMFPKIANGEWQKLDEIGERVRDLALGCCVLRVEPDGDDPEFNEHMALPLWKSFQSLNLMLPKEDRSAMLLRIYNDTTPLINMGIKRDAPKEGAEAKKEGEEEVKAEEIETPVEVKTEEAPAAAEEQVKDAEGDVSMKEEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN72</accession>
    <name>A0AAE0MN72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_435814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677751.1">
        <property type="nucleotide sequence ID" value="XM_062825212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN72"/>
    <dbReference type="GeneID" id="87862366"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="33593" checksum="909083383073170F" modified="2024-05-29" version="1">MANQSKISFLDLPAEIRLQIYRLTWDLDHEPYNFEVLEGRRDPGAVRHDLLKEQLIQLRKLGSLCKTIRNEALTEFFWKTQIYLRHEPYSNADGAWYSDEYQQGLDLIIRDPFLAKHTKHVYWAMMLDKDEEDIDRRMHRGIREYEPEFEVPNMPWPWESYNFVMRLPNLTTVHVDVETYKDWRDLRMWSRCMAELYEWPTVKKITLRLTFKTAKSIIKKAYGSRFVRRGRPQERLTRNILNHLLTLPKDTYRDAPCHIIQNHFGYQCPVWPRVERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNA8</accession>
    <name>A0AAE0MNA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_308934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677419.1">
        <property type="nucleotide sequence ID" value="XM_062823258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNA8"/>
    <dbReference type="GeneID" id="87860412"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="2">
        <location>
            <begin position="668"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3337968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="761" mass="85492" checksum="F0DBE14A7E52A600" modified="2024-05-29" version="1">MAYNPYGAPPYGPPPTFAAYPGVPMAPGMVPPPGLGPPPGMSSAPGLAPPPGVQQPPPATQANRPSGLPASFQPPPNLNINFNAPVIRLGASSLPNKPGMPQGNDRKDSHTPTSANRPGLGSDRVEQSRAQLRESIQNLVPPTPEERLRTIFLHKIPDGLAGEEGVQKLLNTVGRLRRWDSGHSHLSDFKGALFGFAQYEDPDSLAIAVELLKDLEVPVKKQTPTENEPPKDDDEAFAADIDKVKLKVEVDANTTKYLESRKEERGEDAAFEAKLGEAKVALKQFVRDLFYPRLRTGQDADGDTTMADGANAAGDSVEVINIPLAQEDELADIPAEMRETVAAEIAAFRDRSNKRDLERLRREEEFEERERQRNGAPRISRLDSPPPTDAANSNHVPLGPRGVPNAPSGPRGQQGRGVEFVGGGTSNGYNFKDEDDTDADDDELYQREVNKQKAEEEKLYLEAERKWVNRERQRAAALEREKEREKAETEGFARRREEQLEREKSWDDEREAARKHHMYYRDHPHWVRKRLQERNDEQARDEMDRRAEEDQRRKAEAEMEQARGMADSFLERQAEEMERRPAAAPAAPQRFTISFGAAAQKAAQRSAGARRTVAEVEGLLDDEEQEQTTKRQLVPIKFEPITDTKAMSEEDLQKAVRALAQEIPADKDGLWAWDVKWDYLEESIISEKLRPFVEKKVVEYLGVQEQFLVDVVEEHLRKHQKPAELVETLGEALDEDAEDLVKKLWRMVIFFTESEKRGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNB3</accession>
    <name>A0AAE0MNB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_477403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677434.1">
        <property type="nucleotide sequence ID" value="XM_062827426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNB3"/>
    <dbReference type="GeneID" id="87864580"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000048">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3337983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="175" mass="19935" checksum="2AF91C7F82E65459" modified="2024-05-29" version="1">MAQFSAAATQLRKELKQMQKDTDIPGISCGLVNDNNIFEWEVMLMIPDDVKYYGGGNFRAHLVFPHNYPLMPPTLTFQSPIPFHPNIYPSGELCISILHPPEEDKYGYEDASERWSPARSPEKVLLSIISLFSDPNPDSPANVEAARLLREEKEGKHKEFRKRCRACVRESLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNV2</accession>
    <name>A0AAE0MNV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sin-like protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_475398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678456.1">
        <property type="nucleotide sequence ID" value="XM_062827306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNV2"/>
    <dbReference type="GeneID" id="87864460"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="417" mass="43696" checksum="4148D04B3DD73CEF" modified="2024-05-29" version="1">MASPHPTTTNPSEEDDPIVATYNVFIKPPLPEDRKLVVLRYVTKTAQDPSSIKPPRINSFRVKPETGIYEVDIPLETGDGYNKGKGIAWGVALAKSMESKKGGSLGLAGGFNIGGQGGSARGGPGAGGAGGGRRGGNTGGGDDDEAQNMSWPEAVAQGKAIIDQKLTGSRSAGEDYVKHMVGVFQGNNIHLTPVTSLVQLRPVAPYLDAATEQERLSRLGPSAGAGAGGPADKQAAGRAIHMSIKSSDSGGAGAAAETMADRLRAVQTEPWHSLKWYHDEHGEAWDTYNECMLLRSSEAGNAAPPVEEEEVDEEKKKEKKEEKDGEEAEAAAAAEPTDDSGAPDLVEKVNRLQSDWGEEQILRSINGLGPDDKKPGEEAVSVPSVFGTKKATATAKKGTNTKGKGKATSSSNAMQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNW2</accession>
    <name>A0AAE0MNW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_551868</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678486.1">
        <property type="nucleotide sequence ID" value="XM_062829854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNW2"/>
    <dbReference type="GeneID" id="87867008"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
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<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Westerberg I."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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        </location>
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            <end position="107"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="107" mass="11853" checksum="32D0E29598AAF46C" modified="2024-05-29" version="1">MGAHLTNNLLFLPSACLRTACALHPWNPACFDWERSSHQTHEMRSRVCQTASVCSFVHPPFVRCSPHFQTLVGGWNIHEGIALKISSGRQGVTAWLAPYSSHHGTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAK3340369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062824903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPP8"/>
    <dbReference type="GeneID" id="87862057"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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</entry>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Steindorff A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <source>
            <strain evidence="2">CBS 560.94</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679279.1">
        <property type="nucleotide sequence ID" value="XM_062822551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ10"/>
    <dbReference type="GeneID" id="87859705"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="39"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="710"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="921" mass="100162" checksum="589EE7CBB300326E" modified="2024-05-29" version="1">MRPLSEAKSKWEETMRYSSKPSSFLDLQQAIKHHPQDSPCLTGCRSVCWKILLLFRDSPTEKWAEILSGCRSSYTSIHEKHLRFIKHPELLAELPVDPLADDPDSPWELVRKDELIRSEILQDVQRLPDDPLYHQDSVQAMILDILFLYCKLNPGVGGYRQGMHELLAPIVHVLTQDALDRKKTVAADEEVGPPLMLDMLDSAYVEHDAYTIFSMLMARASAFYEVGSDKTGEQNTIVEKSRHIHDELLMQVDPELASHLKEIEILPQIFLIRWIRLLFGREFPFEQLLVLWDTIFALDPNLDLIDLICVAMLLRIRWTLLESDYAMALQLLLRYPVPPDSQGPHTFVDDALYLRDHPNATGGATIIFKHTRKHPLLSSAAPSVTSPGPQPPASPSKHGFGSLRQRTLGARSPLSSLQQPGGVEALLSGAAKNMIERGEKLGINQAVRDAMGEIKKGLQEARNSSSSRSAAGRSPLRDGYLYQPPQHTVTSMQRRNRQLAALLDESITSLKHLAASGLGETADKEKHIETVEITAAKIQFVKACLEDSSLILPDLEESAPAEREPQAPSSPPPSAPTFNALSLSPSHHRGSADSRAPTVALDTTPVVMTSSAVEEEEEEEAEAEVSISQASTITTLPPAAAPGSTGEADGPPKTPTEMTTPEITTKKPETNGNDPSPSPAAIHVKPPLSPPSTNPSEPTPSSPPPPANPDPLSSSSSPSQPETPEKQQQQQQQQQQQEPPHRPEPLPTRSTIAQSSFAWMLEPEDPSFITPNSSSTLHTTNSPFPPPRSPPTTAFPELGRGRPSSFSHSILAGPAAAGTAGTKTKPRKKSLGKSNRMSNASRERNAFLFGDEDGEDQAAGGGGKKLGLGMGSLGDGIFGLEVISRTSKEREREKGSAKGEEDGKGGGGVEGEGETEAERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQC8</accession>
    <name>A0AAE0MQC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_246891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678980.1">
        <property type="nucleotide sequence ID" value="XM_062822413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQC8"/>
    <dbReference type="SMR" id="A0AAE0MQC8"/>
    <dbReference type="GeneID" id="87859567"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="149" mass="16670" checksum="7E1C5674452C9E2C" modified="2024-05-29" version="1">MPGGVTVRDVEPHKFVNAYAAFLKRQGKLPVPGWVDTVKTGPAKEMPPQDIDWFYVRAASVARHVYLRKTVGVGRLRRVHGTAKNRGSRPSHHVEASGSVDRKVLQALEKIGVLEHDEEKGGRRITQQGQRDLDRIAQTVIEADEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQF0</accession>
    <name>A0AAE0MQF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_249825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679055.1">
        <property type="nucleotide sequence ID" value="XM_062822444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQF0"/>
    <dbReference type="GeneID" id="87859598"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="150"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="546" mass="62325" checksum="4E05FDEEDE3591CE" modified="2024-05-29" version="1">MTPSVDHYHLRLFTTIDVSKSSFPKSSISGATVCSVVPGKLSEYTHKTLDDGHEAYYACEPTLRANGYFVPDKSAPTTPDDSYRGPFFLTKGRRVLPRYINFELIQGWLQQCDHDHIESRPNRNTTHSAPLRCIDCFSREVVRLSPGADYVAPSYVWGGISTAGMLKREQGTGRLFVPEDVPQVIGDSIVVVKSIGKRYLWVDQCCIDQNDNADKMAQIQNMDNIYQGAYLTIVAAAGKDSTYGLPGVSWRPRREQLYVNIGSFALVGSLPTAHEVIRNSIWATRGWTYQETVLSRRLLIFTNYQAHLVCPAQIWCEDKALSRGSTGVISHEPVPVLSQIFETKRYRRGATDLRDAFRHFEQFSTRDLTYEGDALDAIRGLLSRCPFYTYYGVLLQRYESPEDTSQSRHRTTLPVEFFQSLWFFFEPSEGSFEVRRRPGFPSWSWLGWKAQKGVDYSKINPSLRNEEDSEYRLERKAIFWAEEHNGAHVQLVDLLLSPTPSASSSDSTRIIPELSMYLWWRIWCSNFSFRTTTRSGPIILMKGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQU7</accession>
    <name>A0AAE0MQU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_472801</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679490.1">
        <property type="nucleotide sequence ID" value="XM_062827164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQU7"/>
    <dbReference type="GeneID" id="87864318"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="28"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="251"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="568"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3340548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="761" mass="82313" checksum="45404F9DA3E3CF27" modified="2024-05-29" version="1">MSSPSVIDHSPHDSAPSPLVPTASNLILIDNYDSFTWNVYQYLVLEGAKVTVFRNDQITIDELIAKNPTQLVISPGPGHPRTDSGISRDAIKHFAGKIPIFGVCMGQQCIFDVYGGDVSFAGEILHGKTSPLCHDGKGAYAGLSQDLPVTRYHSLAGTHVTLPECLEVTSWIAKEDGSKGVIMGVRHKEYTIEGVQFHPESILSAEGRGMFRNFLHMQGGTWAENEMLQKEAQAKASSTNGTSTPKKSNILQKIYAHRKVAVDAQKQIPSLRPSDLQAAYNLSIAPPQISLVDRLRNSPFDVALAAEIKRASPSKGVFALDIDAPSQARKYALAGASVISVLTEPEWFKGSIDDLRAVRQVLNGMPNRPAVLRKEFIFDEYQILEARLAGADTVLLIVKMLEYELLERLYKYSLSLGMEPLVEVQNTEEMATAIKLGAKVIGVNNRNLESFEVDLGTTGRLRSMVPSDTFLCALSGINTHQDVLDCKRDGVNGILVGEAIMRAPDATQFIRELCAGLTGPAPKSAAEPLLVKICGTRSAEAATEAIKAGADLVGMIMVPGTKRCVDHETALSISQAVHMSKKTGSTEASSQGSKSARDFFNINAEIIRKRGPLLVGVFMNQPLEEVLEKQRLYDIDIVQLHGDEPLEWANLIPVPVIRKFKPGQVGLATRGYHAVPLLDSGAGSGTLLDLDSVKKELEKDELVTVLLAGGLEPGNVAETVKSLGALGERVIGVDVSSGVEEGGKQSLEKIREFVKAAKSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR83</accession>
    <name>A0AAE0MR83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">OMP decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Uridine 5'-monophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_182874</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681302.1">
        <property type="nucleotide sequence ID" value="XM_062821529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR83"/>
    <dbReference type="GeneID" id="87858683"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="12">
        <location>
            <begin position="42"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3344689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="398" mass="43853" checksum="6C4854C1AA3B3D5E" modified="2024-05-29" version="1">MSTTQEKQPHWSLKQSFAERVESSSHPLTSYLFRLMEVKQSNLCLSADVEHARDLLALADKVGPSIVVLKTHYDLITGWDYHPHTGTGAQLAALARKHGFLIFEDRKFVDIGSTVQKQYTAGTACIVEWAHITNADIHAGEAMVSAMAQAAQKWRERVPYEVKTSVSVGTPVADQFADEEAEDQVDELRKIVPRENGISSAKDTDGRKGSIVSITTVTQTYEPADSPRLAKTMSVGDEAVFPGIEEAPLDRGLLILAQMSSKGCLMDGKYTWECVKAARKNKDFVMGYVAQQNLNGITKEDLAPTYEDDESATEEEAQADNFIHMTPGCKLPPPGEEAPQGDGLGQQYNTPDNLVNIKGTDIAIVGRGIITAADPPAEAERYRRKAWKAYQDRRERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRC0</accession>
    <name>A0AAE0MRC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_244899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681066.1">
        <property type="nucleotide sequence ID" value="XM_062822373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRC0"/>
    <dbReference type="GeneID" id="87859527"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="596" mass="67627" checksum="F821CE7097D9F814" modified="2024-05-29" version="1">METMESSDIQYGTPIELAPKIIHRFYEPIMLLEALKEPVGKPSSAPPQPMRVDDENPKQLFQAFVYKLAHVCDWEKGGKTVTSIMVLDTTNVLTDEPEFTYVFGVNQATPHHLKRTASFLHTVLQKVASASPVSEAEARNAAERELRQIVLRFNRPRVRFYLKSLRDKAEVCLRQCLAEDKKEDREIAKGLQDLLESEDYTDTDMTPEAEYDQKCKNISHQLTTIFSSKRLKDILAARAAAGRTAMTGHTSMACWSDLVHTAQRILAYRGSVYYFFRARDGWPQLFQNNPRIVALPSGDLQDTPRRNKSMKAEGIVGRMTSNEKLMAIFKRFVQDLQILDLDTRLVDAYEKNTPLAVHSEVLLHHWLLTDRGKGEISPTMFFNSWPYIGSSKPTCKLCKYYFEESRSGVEVRPSHGNLYPKWRLPDVYDFHGPDAVKRRQIMLDRILQRVRTEVFNAIKMKSPLSYKPEDSNTWSATMHLDDRWTQNQTDAGTDAGTRAGTVADWAENASVIVHRADAEPAPGIINDVDSVKSDVLEVSVEDLRGCPPQEEVDEADVRTHTGMEQEEVDEADVRTHTGMEQDEEEEDDDDGGGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRK9</accession>
    <name>A0AAE0MRK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_194460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681692.1">
        <property type="nucleotide sequence ID" value="XM_062821691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRK9"/>
    <dbReference type="GeneID" id="87858845"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11404">
        <property type="entry name" value="bHLHzip_Mlx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="467"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3345079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="564" mass="61220" checksum="75B87E775AD6BC13" modified="2024-05-29" version="1">MAQRQLHTASRHPSLQLSSHHLPPAGPTSADMQPPPPLHHQEPPTPDQPQPVFGYLPQHTAQPPAPLATLLTDDQSRYLDSFFQNLNDASAADDPFLISPNFEEEGLSFTSEWNTRPGNLVGSNTSFAPFARTSFNTAFSDLSSVHSFGGPSFNHQLQAPLRSTDGIHDLLNAAAALPREAGGHGGNTFEQSYGGRRTTGGQHGIQQTDNSFGGAAIALAMRPYAPVNEPPNNFYRDMIFQQPGQSRQNSYQHEQPVSIQFGTDTSFSQSTFTPQRTQESSEVMSQAQLKVLDCLVPSQSAATTRASSPVAQAQGNEHHGSSTPPRLRTHHRPSLPQALASIQEEGGPPKKRRATVDNTKNNDAEMASPGSLVTFSNTPYSPFSQSGFAPSSPMTSQGGRRSAGSGVGGARGKKLSRQGLPTPDEATDSQAQGGDPQSPNEDEDKPTRPGKRRRSYKEKKPNLTLEQKRLNHIDSEKRRRYMIKSAYDNLSIIVPGYKEAGVSKAGGIQLAVDFLKKMMEENEGLKERLEQVREKAGVQRKDVEMTEGGGNQEGREEGSGAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS27</accession>
    <name>A0AAE0MS27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Scd6-like Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_186684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681439.1">
        <property type="nucleotide sequence ID" value="XM_062821582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS27"/>
    <dbReference type="GeneID" id="87858736"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041897765" evidence="4">
        <location>
            <begin position="27"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="5">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="6">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="7">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="536"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3344826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="614" mass="63742" checksum="BD910E2DA1A2C28C" modified="2024-05-29" version="1">MLATPPRHHLLVLVTILTLLSPPTMCRLLTVRPSFSSRISLISRSDIRYVGTLHNINSEESTVSLENVRSFGTEGRKHNPDEEVPASDQVYEYIVFRGSDVKDLRIEEGPSAPKENKPPVPDDPAILGARPRQANVAPGPPGPPGPPGPVPPGPIGAPGHQGPPPPPGAPGFGYYPPHMGGWGRAGAPPNAFGGMPYPPPPGWFPPGQEFPMGHGPGPWNNYPYPPGPGVAPGGVPGQGGRQSANQTPSNQAPGPKPAPIGPAGDKKPSTPSQPQQQPQQHELSADVLKSFGQQPAAGAPSLPNDSKPTVEEVKATAASLNNAAPAGPSSQQKTIPTGPKGNTTRPTQILPAVPLPAALTARPIQPTAGSAKPTGEIGSGPMSAAQLRDATQQARAAVAVAMANMVKLDGQVATQQQVTAAAVDNLTKRVNEMNVNAAATASAPRAPLTHNAATANRGGRARGPRPAKVEVPDSDFDFESSNAKFNKQEIVKEAIAGSPLGEEPAIESAAPEAVADVSGVAQQAYNKSKSFFDNISSEAKDRAENNGQKPGGREWRGEEQRRNIETFGQGSVDGGYRGYRGGRGRGRGGRGRGFRGGRGASNGFPRRDAPAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS51</accession>
    <name>A0AAE0MS51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family group 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_427012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682338.1">
        <property type="nucleotide sequence ID" value="XM_062824660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS51"/>
    <dbReference type="GeneID" id="87861814"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="110"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="238" mass="27512" checksum="00BDB77CFE84AC1B" modified="2024-05-29" version="1">MFINDDGLQLISKEDHQERIEFYADHSIGWVARPRHGENGFQRRSKFKKAPNMNFTLMISCKMEEKLSQIQKSPEWSQNDEAQAYKRALQEVLAEDGRAWTDGNIRMGDYILLIDSDTRVPADCLLDTVSEMEQSPDVSIMQLLEQFSSGIMQVVHTYFENGITFTNLIYSAIRYTVSNSDVAPFVGYNAILRWSAIQQVSYEDEDGYEKFWSESHVSEDFDMALRLQCNDYIIRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSJ0</accession>
    <name>A0AAE0MSJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_153738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682788.1">
        <property type="nucleotide sequence ID" value="XM_062821117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSJ0"/>
    <dbReference type="GeneID" id="87858271"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042045187" evidence="1">
        <location>
            <begin position="23"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="264" mass="27971" checksum="F0BC6FBC5CCE8FFC" modified="2024-05-29" version="1">MTFTLTTSILSLLTLFISLISAAPMMGGGFGGFGRAAIGGFGRAAIGGFGRAAIGPYGYGMGFNRAFNNFAAYPYGYGMGFNQFNAFPYGMGFNRVNSVGDPPCDECYENSIKDIPVYVNNMPPMPPPSPAPVIYNEIPAPMPSPPPVVVNDIMAPPPQAPPTIMNNLVPNPEPNLPPTVMNNVPPPPPKPMPPMVVNNNVADCECDECGCEGGNAEFVQQDVEYVEQPAVAYMPLGTTSIVEDVNNDFAEDGVVYGGQSIVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSJ1</accession>
    <name>A0AAE0MSJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF829-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_589253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682296.1">
        <property type="nucleotide sequence ID" value="XM_062831026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSJ1"/>
    <dbReference type="GeneID" id="87868180"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF40">
        <property type="entry name" value="DUF829-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40230" checksum="5079036C6DF4E511" modified="2024-05-29" version="1">MASTAKAVTKDSSPLSFMTHLSQHVYLYRPSTSTTPSPTTTTTTGKRPPPKLILLYSWMGARDPHIAKYITPYQALFPSTPILLIKSEMKHVFKPKSAWPEMEGVVPVLREIFGSEMLQPGSDNFGSVEGESSTALASSTTSNSIHRENEEDPDPELLIHLFSNGGSAQLLSLHQYLLSQSTLRLRLPSHLTIFDSAPGKMAYFPTYLALSHVLLPPPSRARFPLWLFSLSTLRRLFVAPLIHLWVSLLWTSNFLSRLLRLRFLESPLGKLAREQNDTAPDKGRAEREKGRMYIYSEEDELVGWRDVEGHMAEAKRRGKRVRGEKFAGTGHVGHARGGGNAERYWGVVNSFWEGEGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MSL7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_461030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062826580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSL7"/>
    <dbReference type="GeneID" id="87863734"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="109" mass="12267" checksum="C0D628A7AC15B4BE" modified="2024-05-29" version="1">MSSIGLDVIMMIESYTDDKGYSANERVALAHNIIEASNLDTYEKIRQMMFSLHGYIVNLGKTYYKARDVEELLTIQRRERLAIELLGSASGTSPKNKEVDVPVPPSTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MST3</accession>
    <name>A0AAE0MST3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromodomain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_425984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682204.1">
        <property type="nucleotide sequence ID" value="XM_062824609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MST3"/>
    <dbReference type="GeneID" id="87861763"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05499">
        <property type="entry name" value="Bromo_BDF1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
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    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="414"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="634"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="890"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="730"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="116048" checksum="3F387BF2F1D71F2D" modified="2024-05-29" version="1">MATEAPTTAPDAPVADAPKSDAADATADAEPTPDALVKDVANGDQKEKEVNGHADDADVSPKTLVPETKTDSLPSPKDEPSLEEAQTTPAKKEEDAPKAEESKEGEGKSDEKGQKEDAKPAPVEEEKKAEEPAKEEEAKDEGDKMEIDAPEVPAGDAPKEPIASPAEDKVPELAAEEKSKEEKPAAAEEAKEDKPAEPKADVATEAKSEDGPAAKEEAAAPAATETPATEPASQPPASPAKQQEDVEMADAPATVEEPAKPEQAKPAEATPTATQQETQDTAVSDVPPPTPAEDERKEKDAPRPSPAAPVTADTSMSDAPPPSSKPYREREEDSEDEPVSKRAKVSPVADQANAKSEAKREDKMDVDRKPAASSASTPVHDRSEPKSLADDSLNNLPISDYMNRQIRQVLAGVKKTKAGYHFRLPVSELWPGLWNEYSAKVKDPTDIQTMEKRLRGNLAKYQTLGDFKRDLDKLVQNSIAFNGEYHDVTNAARSCRETILSRLGGCSAFEPSRPEKKDFAKQHPTRHAEPRAATHHSSPSAPLPQRPQQPRVNTAAVPAPSSSKPIESPAFAIPANNNGMPLIRRDSTKPDSRAKRPVKPTHSKDLVYDTKRKKKLIPELRFCEEVLTELRKQRYYEFNEAFQKPVDPVALNIPTYHKIIKKPMDLSTMQSKLNAGDYANAKEFERDFELIIKNCRLFNGEQHIVYEQALRLQSLYRREMSKKDEWLAKHAPAPAPHHSSNTSPRMKDESDWEEPESEGEPEVDEELKGAQQRLASYMKRLEEEQKKINDIMLEMNPNMADVEIAQSVVAMLQKQIITERSKIASMQPTKKAAPAKSHHAKPAASKPKKAMPTGGSSHHAGGNPTKKASGGHSSMGGHGGGMGGMPKKAAARKPAPKRKMGTVEKEVIAAGIAELEGAQLERAIEIIKSDTGTGENDSGELELDIDQLSQEALTQLYDLAIKAFPHLQREKERTMAAQAPPPPPAAQRSKPVQKTKKNKPMSKMEQERRLQQLNELRAQAGRQGSGSQEPLESIEGTGRASVDPAPQHHREEDSEDEESSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTL9</accession>
    <name>A0AAE0MTL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_574981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682340.1">
        <property type="nucleotide sequence ID" value="XM_062830603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTL9"/>
    <dbReference type="GeneID" id="87867757"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="266"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="909"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3345727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1068" mass="120998" checksum="667AB1195C563C96" modified="2024-05-29" version="1">MPPQSESFKRALARFQSEVGPKRAQEFSNCSLQNVHLLMKQIQDKQGKNRELRAFKLLESFLEAMKELGKVIEVFTNTTVFLCYVWGPIKFVLMAASTHLQSLERLLDMYSDIEENLAGLLHYEATFERNTRLASVLEDYYLDVLNFHKEALAVFDRNRALTRRKEILNSEKLSASLDQIIKLRAAIREVYTSQKQVADKQEEETHKERKKAIMGRLSIPDYQSDYRFFIDCRDDSNDTLGTSSGTWIFDNPIFQAWHLGDASGKRVLYIHGRPGGGKSTLMATVIEWLSKDMRPDVALAFFYFRHQNADKDNLNSLLRALLGQLYDRDPVLAAHIEMETSKHDGLRSQVLQELVSTAVGTYATTYLVLDGLDECANDEEEKAIKWLLALCKRSPGLRLLFSGQRDGVLDHLLRSSKSAHSILLDTTPGHVGNIKDYCQSLARDIQTEFENELEPSLEQKIVDLVSGKADGMFLYAKLVLEHLLGLSSIAELKQELQPGVFPASLEEAYEKLEHRLQKDSSRAKSKWKAAIRILSYVVCCKRTLFWREIQSLFSIDKLTGEVDYDRRPVKSYKQLCGSFLDSHTVNKDYTGPEDEVHLVHETAREFLIRRQIVNTTRVHLELSIFCSQYLLSPPFASGIAEDDVMSYARRGSYALQDYAAQYWLDHLRESIKASGTLQSAGRQEAIQWAYRFLQSYGDHAKMSTLDDAGGFPSVDQVAGRIPEHGGERNSYFNIEERTEAIRQAIGKLDEQTLTSRETKILSQLQGPLNVHKCSKPWCKFFKGNLQTPEVREKHISHYERLFRCTVESCPMSTVGYSSSAELRKHISKDHKQSSNRNRFPKLATFGLLDDVNESPDAVDESLDDVDKNPEFRDLMSASRRGDTSTIDDLLGARTAKEARQMVNRKDKSTGEAPLLIAAENGHARTCRALLEWGADAHSMSLIGTTPLLTAAKVVEEQTSFDICSALIEYGARVDADNANNAHRDTAVHLAVARGHISTVDLLLEIGVDILELVIKSREFRHLLKELLDYPKLEISASEWYDLVSRIKGKVVGLDEETKDAIDGFKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTY0</accession>
    <name>A0AAE0MTY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_548132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683434.1">
        <property type="nucleotide sequence ID" value="XM_062829559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTY0"/>
    <dbReference type="GeneID" id="87866713"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="63" mass="7059" checksum="98CD9F9654BE9A0B" modified="2024-05-29" version="1">MELDHYPDAPVYHSPLNKPTTQSQGTSNYYYETTPPLSQQEADSRQMATVALRAPAQPSTFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU73</accession>
    <name>A0AAE0MU73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_519158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684467.1">
        <property type="nucleotide sequence ID" value="XM_062828713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU73"/>
    <dbReference type="GeneID" id="87865867"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042172415" evidence="2">
        <location>
            <begin position="28"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="625" mass="69187" checksum="0425AFFB6F4603DD" modified="2024-05-29" version="1">MSLQKPLLHIVAAVLIVFSTALLLSQAGTSSASITTTTTQQQPPIPQQPQYQNPQENDSQNICKTTHDQPNPLATTFPNNATGGVIIPIPLFLARRLVPSQYAILELAYRSLVPDFPEGMYPVLLQAAHDHDIQLRAYGIVLEDFSRIGFEFPFLSPSGPSGDRYSSYRWAPAQLISVGNDIAIDGSRAYGTRVSPASFEPECEAYRALLNGNTYFKGVSTAFNALGTNSSVEDNVDLSKENEMSIELEMTRLVSSSSFESNSGSPPYSLDFFKNITNQPTFASPGGTCDNMIRLFDTSMSRGKFAPVPVRGRVKAVNVFPFVAEGELDSDSDSDPSGSDSDDASRGGQREWEWTDVYGVQVATPFIENNYLDCEAMRGASTSLYEYGGLPYALWSGEQFKIIYSDARAKTVNVLISNEKEQKWERQVLFKSETHRYGDFNCHPGTPWVLAVEEDHTNPKPEDVRNSVVLIHIETGEVRSLRGSGQHDFVAYPRFNPTDMTQICHIHWDHPNMPFWGAKLSVMNLDLTNSTVSDVKIVGGDDTSTAAEPRWGPDGQLYFGSDKSGFRQLWKYHKGDSEPILLPGWEDAEFGDAHEAVGAQSYVFLTDKEIVAAPVRFGEMEFVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVK7</accession>
    <name>A0AAE0MVK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gtr1/RagA G protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_456955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684425.1">
        <property type="nucleotide sequence ID" value="XM_062826329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVK7"/>
    <dbReference type="GeneID" id="87863483"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="526" mass="57700" checksum="9DED8E1983B27897" modified="2024-05-29" version="1">MNRSLFNNEQRFISIERPIPALQLEFGTIQPTERSNTAYPHSALSAHRLTDKLIDQNDCNLSPFYFTDTSSHLTILNDVNFTIHSAAVNTQTQTHLPPASPSPPHHTRLGSHVTMADYDQPSMGSASAAAAASAAAASAAQAQLKKVKKQKVLLMGKSGSGKSSMRSIIFSNYLARDTRRLGATIDIDLSHVKFLGNLTLNLWDCGGQEAFMENYLSQQRAHVFSNVGVLIYVFDIESRDVDRDLATYVNIISALVQYSREAKVFVLIHKMDLIQPMTREDVFDRRVALVRRKTAEAVAIVRKQKPEVTGAPPGPAGAVPGSLPSYPEPLSTPIPDLEVEMQLFATSIWDQSLYKAWASIIHDLVPNLSVIETQLASLGVAIDADEILLFERTSFLVVSKWTSPEGESNPYGDRFERMSNILKAWKHTCSKFTGTPRNAEQFSDFEYKMGANFSMFVTKFTTNTYILVCMPPGEARFNSAKLNVAAARPWFRFLDGPMIAPTAGIGSSQMLSGLAAAGGGGGGGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWZ5</accession>
    <name>A0AAE0MWZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_505360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686826.1">
        <property type="nucleotide sequence ID" value="XM_062827985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWZ5"/>
    <dbReference type="GeneID" id="87865139"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="254" mass="28023" checksum="E894FD314354BC72" modified="2024-05-29" version="1">MAASVDGRTFPSGAGTDSLVLLHAAVEPADAPISFHPPDRYTYLVLRSRSRTPCNCRDAVVEKAPLILIGAMVIKAIPKYRRSASLVGALATIWTQEKSHELLEVRGQQDWPAMAAQILIRANSKKANSKVRTINSLIFPAASRGPSRYTPHPGFHTTYHSLYTSATKRHQTGPDDVDLGFVFKPYDLLALPAGTRDVLYRENPACEGRYVQTHDKLHLSASKHSLITNYQARALVIFLPSRIRIPAYSHGWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXV9</accession>
    <name>A0AAE0MXV9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_49442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686870.1">
        <property type="nucleotide sequence ID" value="XM_062827776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXV9"/>
    <dbReference type="GeneID" id="87864930"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="5">
        <location>
            <begin position="569"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="744" mass="82340" checksum="178C7812FA41013F" modified="2024-05-29" version="1">MAAPKKVCIVGAGPSGLVAAKSLLHDQPKGTFDVTIFEAQNRLGGLWPSRKDDNAGFVHPLMAANQSKHTVQFSDLAWPDDAPEFPRAWHIGRYLERYHDRYCQDAKLCLGERVVHSELLEGAKWKVRTCSQDGQQLDHTFDYLLVASGFFGKPVIPPPVATSGDIPVVHSSQYRTLSALLEQTKGAGRKIVVVGGQMSGVEIAGTIATHLSSALHSPGSSTLQDLDKYSIHHVCQRPVWVFPLFTSPKPASPAPPFLPMDLCSYNLANRPDNLTNMQGHVSTEAAKTRHSIFETMLGTDQSDFSPSLAITNTDTDKPPYLAVSDTYADFVRSGLISVSHGKVDSLTGSTVTVTTARGDVSKIDNVAAVVLATGFEAASSISFLPSSVQETLSVVPSDLNTTVALAFHGTHHPAIPSLGFVGFYRSPYWGVMEMQARFVTALWTAGGPASSSLPPKMAVALGEDDSIERTLALRTDPRVSQFPMGDYPWLMQEFSKALEIDRIPPLGKMPRVPPADKSMDILTPARYPAKRTSEAQRTEVDKSIQQTESTTWSGVSSARFVAKAVFRSLLGEWKLERDLVSRLPTHPSGHFSGTARFLLRERTRDGREAEHDAALDRDDDIGLEYLYVEEGMFAASNGLSFRATRRYVWRYDEKKDKLSVWFVKTDDQKRADYLFHQVEFIIPDTETEGAPQAWRANAGHLCIDDFYDVDYRFNFKAINLKDWSLAYRVKGPQKDYIIEGTYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0F0</accession>
    <name>A0AAE0J0F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_481084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676725.1">
        <property type="nucleotide sequence ID" value="XM_062827616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0F0"/>
    <dbReference type="GeneID" id="87864770"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="285" mass="31624" checksum="7371C4619B1A2261" modified="2024-05-29" version="1">MKIAITGARGTVGKEVVRLCANQGHATVQINRTHQDPDTSTPNTEMRTADAANDYDAILKAFKGCDAVIHLAAIPDPVDKDDHLVHSNNVCAAFNGMRAAAELGIKKFCYASSVNAIGLVYSNQPLSFDYFPIDEEINQDPTDAYALAKQEAETQARSMARWFPGMKIACLRIHQVAPKKDVEKDYRESNEKAVKQLWGWVHPQATARACLAAVENSDEFEGAEVFNVVSPERCVVGEDAKLSNEELVKKYWPGTKIKGDMSGNKGFWNVEKIERVLGWKHEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0I9</accession>
    <name>A0AAE0J0I9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_79124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676466.1">
        <property type="nucleotide sequence ID" value="XM_062831422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0I9"/>
    <dbReference type="GeneID" id="87868576"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3334300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="358" mass="39248" checksum="7691BDFA1CBA520B" modified="2024-05-29" version="1">MGRFGDFSSICRIAPIPLCASVGPITSIASGVGIEPDCYARNIEVANTIIFQGAASVMHIVALVMTVVMLLHVRGKFTAVGRKEITTFFYLYMILTFLSLCIDAGVIPPHSGSYPYFVAVQAGLASALVTCLVINGFVGFQLYEDGTPLSLWMLRLSSFVAFVISFLVGLATFKSWAGLGPTNTVGIFVVLYLLNALQLLIYVVMQIILVTRTLQDRWPLGDIAFGVFFFIAGQVILYAFSSPICEGISHYLDGLFFATTCNLLAVMMVYKYWDSITKEDLEFSVGTRMNNWEVKELLPQGPEEDRRATVYADPIYEGHYAPGPGTGSGASASGYEGGHHRRESHGYTPSPNRQSLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0L8</accession>
    <name>A0AAE0J0L8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_534668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676830.1">
        <property type="nucleotide sequence ID" value="XM_062829009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0L8"/>
    <dbReference type="GeneID" id="87866163"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF14">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="214"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="755" mass="84679" checksum="EC9A27042B018074" modified="2024-05-29" version="1">MSPADVRVTRDQKLGKQSRIDSSAASCPMCQAISSLVRTAGLYTPHHEFFEGDPDCSLSIYCDPVDGPAIEVPKSAGNDKILGWLTAKGLRSGQSYPVALLVFFGRISLTWNAPVTAPSLTLFDCFQTLDPAEDEIIGDTSINRPRSLFSGRERPVIIDPDLPRRWLRSCLEDHKDICPLNRRQNRTASTFRLIDTSTKAVVEFRGHRLGDIQYVALSCVWGNGHKITPRHDTVTQLQLTGSLPVAGPQTVLDAIKFTSDMGIRYLWVDAFCIIQDDENDKAAQLQLMAEIYQYALFTIVAAAGNNAQAGLPGISIPREAVQQKVLVKKAESPELAPIWLISTLAPRDKMREYAWSTHGWTLQEKVLSRRVLTFTDKRLLWRCRQCKKWEEIDTETASDLSCSLRYEGTGGRSLDLDPFMEPNPSRIGQAEITASPWQNLSSLISEFARRDLIVQGDAHDAASAILREYTIQTGVQFLWGLPADARFELALCWHYTTKPSELDPHAGKPLRRRQEYTTLPTTSLQQRVPFPSWSWLGWRGPIDLPDLDYSQVLTPIVAYVLKNTPLELVRTSTLTPEADTHAPTSHKQNDDPDASLVTLDMIVTELPDLTFDRLSLIPDDQILFFWAETAHFFLSPLSKSNHSSDRGRPIYDEKGEYCGDVGPLPGAVGAVDDDADEEDDFGRDSSSARDAKGTSTSTSNNNQRAEFIALRRFTYICLVLQVERREGIVYRVNIWQIDAQAWRRSRLRRELVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0T2</accession>
    <name>A0AAE0J0T2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_76670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676741.1">
        <property type="nucleotide sequence ID" value="XM_062831384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87868538"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="364"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="635"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1280"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1452"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1532"/>
            <end position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1617" mass="182506" checksum="BAC8258F8B273E0D" modified="2024-05-29" version="1">MIDPFTALGLASAVLQFIDFGSTVYGEYKRLRNGSLNGNNARAVSKSFEAALNDLTNVNRVLKSTPRLHNASETESILIQHEEAINSLLDQATDMAEDFLNQLQCDPNRYGWNTLAEAIGSVRTEGELDKFKEKLDGFKRDLGIHVLAMVNAKVDHYGMQHHYDLAQQREEIVQLRQDIHRINENIVKIVAFNQRGIKSGSSTPIFDQHARTAAEAKQGGGPNPVIVAAMITLASGETRFIYPRAKAMGVNGSGSHQQLGHFNKGSESGSFEDAKFDTVLRLSSDPGLMGQPAGAEMEHVPTKDFATISKAVLDMLHFRQITDRFESVKTPYESTFSWVFSHLNNPSTFDNICRPWSNLSAFLESKDEKDKCYWIKGKAGSGKSTLMKYIVSDRRLQQHLQRWAGPSDDLIYANFFSWHLGTDDQRLISGLMRSLLYQVLCARPDLIATIMPEMCLEAAKSRNGQLETPSGSELRMWFERLLHATATNVGNFRLFIAIDGIDEFQGDPEELIHLIRNTRGDRVKYLVSSRPMQACAKAFGSCPSLRLQDLTEDDIRRYTEAMLGEQLRDKGGEDWFRLVNEIVKRAEGVFLWVALVIRSLQKGLQNHHDNLKEMRKRLDQLPSDIEKLYGHMLKKIPPDYKKNAAKLFRIVMASIDIEQQIREHPVLAIQLSLAEGVWDEVKLIPEGSLTWDLEEVRVRDIEARVSSRCLGLLEVHTRKDDKTHKPYIDFTHRTAVDFLRESQIAIDFLYGTLSSDFNPQAYLVRSCLTLARVMPTTTRFDGDVVWDSMRTCLEYARIAEYKKRPVFDGYLDRLDQAMSRHWFAALSSTTPYNSSSDIHRLHHWAQKAFWFWTGPKDVDMARVQAEFNQFCYPSLYVNNDPTSTSTSLDEENQRLLGEIDLGFLVVAIMYSLPTYLRTCLHRLKEAEEGIEATMKRKSTRKTLINKIDKIKGGKQTYVPPKVAHTATRLLFLWAQLTAASSNFCIVPWTKPHARVCRTLLEFGANPMCEFTFSMGSGKLSAHRNAWELTSQAILVLVHPALRKKNLTELLPNQKVRAVLWITNFFVKNGADKGSKVPSVVLHGAGMKNLVLECPGRAKDEEATLLEWLEPYAKGPATNEVGKKLGMIMRKTHRVLKGVHKTKGWRRRKSRRPNGEGGDDFDEDSDDYGSEDDDDYDDDSDDDGRSVIMPARRDRGEQIILRKPLRRAGSGDTLLDDAIEDKPLPPIPRESSMLSTQPSMGEIVDEDYGRAKTPVMHHQTLPDTPPPSAPDEIFFLPTASFVELPNSTPPSPTGTISPILPQQPEPEPELAPTPPPRPHEPSPEMQQTPRFPDLPRMPLSPLSQRFPLSPLSQRFPLSPVSPRMPLSPLSPRTPIAPSPADFLWPAAFRAVAHHRRQTEPFPGLGINPSQATLVDPNSDDVEDLYPDVNPHSRAPPSPSLSRRSSTETLVEPKAPHYTRESLGKKPDMERPVHPLELAMQRGQLNDDSEDSDQETVRPRGRRGMRDRSNTMTTSTTSATTTTTATTSTTTGNRHREAREMKRREEKEDKERREREASRAARRLPEPKSGKGGYAKYLGQTGAKAAAVVPQKLFNLAFWVGDWCKRAYGRCSWVVKIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J101</accession>
    <name>A0AAE0J101_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_565852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676706.1">
        <property type="nucleotide sequence ID" value="XM_062830300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J101"/>
    <dbReference type="GeneID" id="87867454"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042020591" evidence="2">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="351" mass="37563" checksum="59C113E9F60D8387" modified="2024-05-29" version="1">MPLSLLRASALLLALSRLTPSVLSQNTDEDKDTDEGGYIGYRLTHRGDPESAIYETANTGSDDDLILPEDPDVYLNASVSVGLIDIEVDNITAKVNLDAKVLSLLHFSAGVDASIDRVKLRIENVSAKVELEARLENVVAMVDDVLRSIDLNPIIATLGEGVGKIVDGVGDVVGGGGGGGGGGGDAAGSAAGNVQARDVPLDAGAAEHDLSKRVPATGGHSSGADHDPFNYNLEHNILYSVNDYQGNRHRNRRLDQNGEIFDEYLDNDGNEQSRTVVGYYKDDMTFNGHNRSIEVDGKVKEFELQYEYKPFPGIEAISWIYVDAEGKVVRTKVISEAQGGGTSTVSNDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1D5</accession>
    <name>A0AAE0J1D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_583189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677056.1">
        <property type="nucleotide sequence ID" value="XM_062830872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1D5"/>
    <dbReference type="GeneID" id="87868026"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="224" mass="25183" checksum="4373162562E5347B" modified="2024-05-29" version="1">MSQFTTGDVAFLLEWHQFNKGGKAMLQRLNPTHYMEGPCGHPVIILNKTATYALVTTVSAHGAGPWDGWRAPWTSGRHYAREADHFRSFAGTQRSNSHRAFLRLSKGAWPKPKGSWVHVENVLLVPLFALGIFTKPKCWERSGTILHVDQTSMHDLMMHIQVANPQWFELLGRLDILAGNKPKAIQTKQHPPHPAAPRPAAPRPAAPRPDESESGWTTVKNRRR</sequence>
</entry>
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    <name>A0AAE0J6I6_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677309.1">
        <property type="nucleotide sequence ID" value="XM_062829202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6I6"/>
    <dbReference type="GeneID" id="87866356"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023:SF1">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
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            <begin position="77"/>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
    </feature>
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            <begin position="560"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3337858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="821" mass="89828" checksum="C3C9C5B01E55588C" modified="2024-05-29" version="1">MPAQTKLAPLRRAASTRFEFRDDDSDSEDVDQPPSGPHPVTGLGISLKGPTPPPEAGVSGYETVPVQPPPRNPRRLTVQQKQTFRPTSSVYSGNSPPLAPHDPEQPSTLASHHFQRYRGGEEISPPSSPEPSYTQPHRPPILPPGDVSPIEEEYEETAQGAFEPQHYGRNQHPYYHGPGPRSPPPNHNAAASINMMRRGQRKLSDAALRDAHANRAPPAQQPRNPGPGFLMVDPVTGERLDSAHGRPLNRPPPGTHYAPGPGFLMVDPVTGERLDSAHGRPLNGPPPGHPYGSGPGFARQQSPPPFAGPQPRMASVGDRMMRMASPGPRESGPDLAAGAFTANRPGWRGPSGRTAIVDPVRDNPEVPPLRIPDRNGRRVVSQAPGPSQRPELSLGIPRRDQMSPPPRVGAQMGYAPRDPGQRVMSSSQVHPQSATTPRPMRSPVYPNPPHSAITPRGDAPFVAAQQLQRDGMGPHYPRAFSPVSPTNASPVNYSPQPNSVRRKPTPTYANHEPQDSVSSIYSQQQPEVSMPKQQPPAPQPAAANSLPADEPWVQPPSRFSMTSYATSISTTATPRESLDDFHDNYHNQSPVPSISQQYRPESPKDEEPAQSIMNRSRPKLEGFDYNKKDQAPIVISLKDQIISPYETVIERESPAARDRRVAATGVGIANGFKPAPRRVSATPSDINKSLPPAPPELEVLSLYNGADGKSSTPKSPKDLTASERVALYDAQIQALGNRRINITRSIKQMTELMPTDNILNSEAVRRKREVEKQKVEALKTELAEVQREMYEMGLKLHRAYKRQEKEASFEPTTLWVRRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J712</accession>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830161.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87867315"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="597" mass="62623" checksum="C19BC70F95894010" modified="2024-05-29" version="1">MDRASSRGRSMSPSELLKRRHSPHQRITEREEDDEEDSGSGDDSGNGSDSDDGDDGKGNDEDQSTTEGEDDNEEQTVTEERTITQQHTVTASPTASGVQKLHHSLPPAFGAFPGSESHLDPASWSWFIQLHTAVLDTSGIVASTWGPIPTEASTSFSSTPPVTITTNPETELIPSTTSISLVYPTTSDGQDLSGEATTVIDSTTVEGSESPKQGGSSNGHTDHPPIPTTTTRVGGGITTPETFSTRSELPITSPTSSTHPADSVIASEGKENTSSDDVLKKGAIIGAIAGLVVFGVLLFFLWRKRKHNKKRHSNSSTSHLFTSTSKNVGKLPNKDPYPFDDNDDRGSIDGESIGRTSQWTFEGVATAIRNSMRQSVSGVGVGATGPGPVSPVSPSGDAASLGGFSSLSRRSSFSYASDDYSCRGSAASNASGIYQATALAYPTPGRATPVMPAYPATAKIVNLSPKPQKPEMVMVRNNRKSSTAELLGLSRNPSKSTIGKSGKGVGQWDKETCGCDSSRASTLSEVSPPPMAARTLYEALGGSGPGPVSPPSSSRPVTWMRQPSPLSTARNSASSAFVPSPIVGTPMPGSNRRSYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7Q2</accession>
    <name>A0AAE0J7Q2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_477740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677551.1">
        <property type="nucleotide sequence ID" value="XM_062827445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7Q2"/>
    <dbReference type="GeneID" id="87864599"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="191" mass="20732" checksum="BDA0994E20D91B52" modified="2024-05-29" version="1">METHQRRRGSPASPASGDGSPPTRQHHPEAGKCGPSPPKRTQSSTGSRTDRHAWLIYPVVSRQPIPPPAPNTPRTMGWRTHEPLGLPLLPRPIQPPGETFRTCICGEPCKKGHFFRCPLVTWQNPRATSDAPHAFGTSHATFLARLRALKDEGLTGVTTTADGRLLGTRAPLPEPDDTDDEAFPIIPPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8F9</accession>
    <name>A0AAE0J8F9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_579676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678210.1">
        <property type="nucleotide sequence ID" value="XM_062830771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8F9"/>
    <dbReference type="GeneID" id="87867925"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="1 4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041780050" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3338850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="313" mass="33699" checksum="B79EB65429568688" modified="2024-05-29" version="1">MKFLFLTAALFLATLTTAHPVFDDLVTPSTPLGYKRAPAASLRQVSDFGPNSSKVKMYIYVPDKLAASPPIIVAIHYCTGTAQGYYNNSPYAHLADQKGFIVIYPESPYSGTCWDVSSRATLTHNGGGNSNSIANMVDYALKTYKGDATKVFVTGSSSGAMMTNVMAATYPALFAAGIAYSGTPAGCFYSQSGGTDAWNSSCANGQARGTPQVWAKMVHDMYPGYEGQRPKMEIYHGSADSTLNANNYNETIKQWAGVFGYDYQKPDATQNNTPQSGYTTYTWGEGKLVGVYARGVGHTVPIRGSDDMKHFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8W0</accession>
    <name>A0AAE0J8W0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_282754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062822903.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87860057"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="7">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3338821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="93" mass="10125" checksum="729050293E566FD0" modified="2024-05-29" version="1">MSDACTPYIVSVQESGTRIRYESLSLTSVGASRVRDLFATARENAPCIIFIDEIDAIGRSRSDGGFRGGGNDEREATLSQILTEMDGFNTTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J8Z7_9PEZI</name>
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            <fullName evidence="4">Uncharacterized protein</fullName>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678208.1">
        <property type="nucleotide sequence ID" value="XM_062824991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8Z7"/>
    <dbReference type="GeneID" id="87862145"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042251253" evidence="3">
        <location>
            <begin position="22"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3338848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="385" mass="40202" checksum="2A605EE0C2235FAC" modified="2024-05-29" version="1">MLWQPTTLLAALLAVAPVVQAGIGSLIAEGMTRGSPSYHKRMEEIMGSYLLRRGFLEERQSDFSTSAVGQDPIFTADGTLNMTAWNAQVNAACISTLRQLTAASNPSGTCVCYNLPALDNSTGVFEADLRLFRINDARDSFAGIKPEQISVGVRFVGANVRTTTADQPVANAAGGGSSAAKASQGASASTSQAETASPSSVSAASVGRVGGSGDGEAANALAARQSPGDLPSNGDPTLLQQYLFLGQIDKGKMTGDMTMAQLQHLLLPIVTLSATTPSGASVSTNISSNEAAFVAGVFSKEVVLSDFNRAQLAVEDEIARLKNGTTAFVLPGVQIMIFPVGLVITSVWLAVAIAAYGYGTFCRYNFAVQYQQRRAVVERGGMARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J959</accession>
    <name>A0AAE0J959_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD binding domain of 6-phosphogluconate dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_591567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678638.1">
        <property type="nucleotide sequence ID" value="XM_062831101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J959"/>
    <dbReference type="GeneID" id="87868255"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="177"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3339278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="306" mass="32999" checksum="DA73A541E73E9A9D" modified="2024-05-29" version="1">MAPRLFFIGLGNMGRGMAANIVEKANLDQPLLIYNRTKQRCIELSEKLPAGKTEIVDSIAEGASKADIILNILSNDAVVEASIAEILKNDVKGKLIIECSTIHPDTTEKIAQQVEDAGAQFVAAPVFGAPAMADAGQLVGVLAGPKASVDRARPYFKGVTAKAEINMSDEPYRKALTLKLIGNSFVINMVEQLAEGHVLAEKSGLGTDYLHQWIEGMFPGPYAAYSTRMLTGDYYKREYPLFAVDLARKDAGHAMSLAKEGGVRLHNVETADAHLAELKAHVGEKGDIAGIYGAVRMENGLPYENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9D7</accession>
    <name>A0AAE0J9D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_433588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678431.1">
        <property type="nucleotide sequence ID" value="XM_062825078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9D7"/>
    <dbReference type="GeneID" id="87862232"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF13">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="548" mass="61235" checksum="0E9C5C1D679EBC58" modified="2024-05-29" version="1">MHALHDRPPPGELEKEEGDTCSQDTLHPSDSVSNRNYRGDAQVHEGPRLDIRIELKKNDAYDELPFSYSKSRKWMILTVIFLVQTSMNFNTSLYSNGLAGISEEFGISLQKARWGAAIFLITYAFGCELWAPWSEEFGRKKVLQASLLLVNIWSIPVALAPNFATILVGRALGGLSCAGGSVTLGMIADMYEPADQQVAVSYIVFSSVGGSVLGPIIGGFVETYLDWRWCIWIQLIFGVFVQLLHQLCVPETRCTIHLDEIAKKRRESGMAPNVYGPNELCPIHQRFSWKELTKNWGRPFRMFVTEPIVLTFSLLSGFSDALIFMQIQSFVLVYNQWGFSKIQIGLAFIPIGVGYLIAWLSFLPAFKRNKRARDLKPHSEHAQYESRLWWLLWTAPCLPIGLIIFAWTCSGPPIHWTGTMVGSAIIGIANYSIYMATIDYMICAYGPYSASATGGNGWARDFLAGVLTVPATPFVSNIGGKRHLEIANTILFAISLLLVTAVYLTYIYGPTLRKKSPYAQSLAKNATQDEFGHSRPPSRISDREEICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9K6</accession>
    <name>A0AAE0J9K6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_511710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678879.1">
        <property type="nucleotide sequence ID" value="XM_062828512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9K6"/>
    <dbReference type="GeneID" id="87865666"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000258">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein (AFU_orthologue AFUA_6G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3339519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="75252" checksum="24B5104375FE12DA" modified="2024-05-29" version="1">METINLVIIGSGLFGLAMAKTYHQFHPTLSLAIFDKAETIGGVWAKERLYDGLRTNNLKGTYEYLDYPMTPEVFGVQPGEYMTGPVMHKYLTSYAEAFGIKDKIRLRHTVLEAEHQGGAEGGWVLTVESPGGEKKMVFARKMVLATGLTSESFLPEFKGQEDFGAPLFHSKELKKYGGTLESAKVVTVLGGTKSAWDAVYAYASKGIKVNWVIRESGHGPAWMTPSFVTPFKLWLEALVHTRILTWFSPCIWGAADGYSLIRRFWHGTAIGRAITNAFWWALGNDVKTINKYSSHPEIKKLEPWAPAMFVASSFSILNFPTDFFDPIRNGTVSIHIADITRLSPKMVHLSNGSKLATEALCCVTGWKHVPPVKFLPEGIEKELGLPHSPDGDAESLFTDEMVARADEEILSRFPRLRSQPVINKRYKPMTETEGLSTSYETNPQARLTPWTLYRFMVPPSPRFLVTRDIAFIGYFSSFSSGLSMYPQALWICAFLDDKLPLSVMPSRKAMLDGKSKLKEGKVGAKEKTVEEMRYEGVLQARFGKWRYPAGHGQQFPDFVFDALPYIDLMLGDLGLKVHRKRSWLAEMTEPYGLEDYKDIVSEYAANTSGSGSGSGSGSGSSGSSSSAWKSNASEIRDVSKSFSSTASSSTDSKVKSYAASETTRWNTMAENADSMAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9N1</accession>
    <name>A0AAE0J9N1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_246877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678972.1">
        <property type="nucleotide sequence ID" value="XM_062822411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9N1"/>
    <dbReference type="GeneID" id="87859565"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="385" mass="43624" checksum="40A97969D821785D" modified="2024-05-29" version="1">MAPAPILDSIVDTIEPRKETLPLPEPARQRLLKAGIDLSKGYPYRPSVPLYLQDVYKIRNEERIYEDAGARADKSKKNLLSAATKVTDLTTHIGTEIEGLQLKDLTPEQRDELALLIAERSVVFFRNQDLAPQQQKELGEWFGEVEVHPQTPQVPGIPGVTVIWPDLFTLERPADFRRPGGASNWHSDLVHERQPAGITHLHNDTVPPTGGDTLWASGYSAYEKLSPEFRKIIDGKYAVYRSAHPYLDRENPDAGPKYIERTHPLVRVHPATGWRALWVNRSMTVRIVGLDKAESDVILNYLYDVYEKNVDIQVRFKWTPGTSALWDNRITIHNASWDYGGRHPRHGTRVTSLAEVPYYDPNAPTRRHALGLLDNQEKSELGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9N9</accession>
    <name>A0AAE0J9N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_283985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678262.1">
        <property type="nucleotide sequence ID" value="XM_062822918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9N9"/>
    <dbReference type="GeneID" id="87860072"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="351" mass="39697" checksum="E706EC5FE50449FE" modified="2024-05-29" version="1">MAAQPAQQLPLLSNEEQAAVGILPASHWQQQSTQEDPNDDSASSLGSFVSSTASLTESIFAYRHINGRTYHGEIGNAESWEPNDERHKEALDIAHHVYTVVLDGKLHNAPLDKKNVQKVVDIGTGTGMWAIDFADEFPDSEVIGTDITPIQPPWVPPNVKFEIDDCNREWTWADNTFDFIHIRMMFGIIEDWDALFRQAYRTCKPGGYTESFVCDSTFRGDETVKDDSAIAQWGRVWNAAGKKMGRTFEVYAENLQQKGMEAAGFVDIEVKDYYIPLGVWHKDKVLAEKGLWWKIHAESDLEGYLNYPFHAVMGWTPAETGLYAAQLRKELNNPKIHGYTTVRSVWGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9U0</accession>
    <name>A0AAE0J9U0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_433403</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678676.1">
        <property type="nucleotide sequence ID" value="XM_062825067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862221"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="821"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="915"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="91"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="676"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="771"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3339316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1309" mass="147260" checksum="F55F1028AB578DDA" modified="2024-05-29" version="1">MASSTVLSTLPTAVSTAVSTASVSGSILSTISSALATTITSSASLTSSSSSSTSSRVLTTTTTTTHGPAKQIPNNDSAGSAQKFGGISLVAFLTALATSLVVFGVQMGLFLLLRHKLARIFKPKTYLVPERERTEPPPASPWNLLSTVLRYNDREIIKKCGLDAYFFLRYLQTLLVLFIPIALVVIPILIPINYVGGLGQQVIDTNTTDTDDSDVPTGLDTLAWGNLRPEHYRRRWAHLILALLVIIWVCGVFFAELRVYVKIRQDYLTSAEHRLRASANTVLVSSIPDKWLTEHALRGLFDVFPGGIRNVWLTRDFTKLLEKIHRRDAIHQQLEEAETELIREAKRRQLKQRSLEEKRVRKAHQVKTESKKERKHRAKAEDDEAKRRAEDNGGLSVGDHESVPHDIATAVHEGEKPEGKGLDDIQEGESEESPHHGPRDGNGLFKVGENLGRGLKKGVDFVGEAGHNILVLPKALQQNVEGELEGTGGFDFVKDGVQPSPTSSTSSEYDSKLHPEDDDAQPKPSFASETPLHASQARHAHTLSEASQASAPQKESDPRTMGNTTRKVSNLNDMYITEKTRWYEFWKPPSGGYVSPVPQGYEREDYPWKVERTKWQKFKAAIPFYHSDIEDVEYPPAFTKDYATEKEEGAEWEKWLSAKDRPHHRLALFDWTPGWLPALPLVNKKVDTIYWCRAELAKLNLEIEEDQQHPERYPIMNSAFIQFNHQVAAHMACQSVTYHIPKQMAPRTVEISPNDVIWDNMAIKWWHEWARSALVFAVVVGMLILWAFPVAWTASLAQLDALMEKYSWLHWLVVNKTVHNVIKGVAGVLPAAVLAILLILVPIALDWLATFQGAKTGSQTTETVQTYYFAFLFVQVFLVVSITSSTFQTIANITQNITSTPEVLAENLPKAANYFFSYMILQALSTSSGTLLQIGTLFMWYVMARIMDNTARAKWTRNTQLPSVTWGSFFPVYTNFACIALIYSVVAPLISIFAIITFALLWCAHRYNMLYVTRFRTDTGGVLYPRAINQTFTGLYVMELCLIGLFFLAVDENDQVACVPQAIIMIIALFLTILYQYLLNRSFGPLLRYLPITFEDEAVIRDEAFQRAQERRLGIIRDDDEATALNRSAPGASDGKDIELRNLHKRTKSEADSLSRLGKLNPVRGIVHAGSWAVRGGRQVRQAAFGKAEDNLRTATIYRNERRQKDIEAQRAIGDALFGGYHDEIEDLTPEERDVLVRKAFQHYALRARRPTVWIPRDDLGVSDDEIKRTKEFSKYIWISNEGTALDSKVRVVYGRNPPDFSEVDIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA73</accession>
    <name>A0AAE0JA73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_432160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678547.1">
        <property type="nucleotide sequence ID" value="XM_062824984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA73"/>
    <dbReference type="GeneID" id="87862138"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000004">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="539"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="672"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="790"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3339187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="854" mass="93136" checksum="B9565C6F5DB8C8FF" modified="2024-05-29" version="1" fragment="single">ATDWVQDAAREQLRRKARRKRNAGLWDAGRFDWRHRIRESYDAAQGWIVVTIIGAAIGVNAAFLNIITEWLADIKLGHCKTAFYLNENFCCWGEDNGCDDWQKWTDLSPINYLIYILFAILFACTSATLVKSYAPYAAGSGISEIKVIIAGFVMKGFLGFWTLVIKSLALPLAIGSGLSVGKEGPSVHYAVCTGNVISRLFAKYRRNASKTREILSACAAAGVAVAFGSPIGGVLFSLEEMSSYFPLKTMWRSYFCALVATAVLSAMNPFRTGQLVMFQVHYDRSWHFFEILFFILLGIFGGLYGAFVMKWNLRVQAFRKKHLTNYAILEATLLAAATAIVCYPNSFLRIDMTESMEILFLECEGAEDYHGLCEKDHRFRNVVSLLLATVIRIFFVIISYGCKVPAGIFVPSMAIGASFGRSVGIIVQALHEANPQSPFFAACLPDVPCITPGTYAFLGAAAALSGIMHITVSVVVIMFELTGALTYILPTMIVVGVTKAVSELFGKGGIADRMIWFSGFPFLDNKEEHNLGVPVSHAMIKDVTSIPTNGMTLQQIEALLAEDNYQGFPIVEDEHSKTLVGYIGRTELRYAVDRAKRERTLGPQAKCTFAPPPSADGTTAANITTPGDIITPGLARMDSFNTIGFAESSSTPAATSSSSSSSSNFINFSRYVDTTPVSAHPRLPLETVMELFRKIGPRVILIEYHGKLMGLVTVKDCLKYQFKVEAMEEVANNGHGAEQQQQQQQQGVSGDERLWELMQRVAGWVSDKVSIASGGRIRLRDSLDLPREALAGGGGPGAGAGAGAAGMGNTSRSTGGRGRGRGDQILEGTEDEDEDGVELLESRERYPRGGSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAC3</accession>
    <name>A0AAE0JAC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_246771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678971.1">
        <property type="nucleotide sequence ID" value="XM_062822408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAC3"/>
    <dbReference type="GeneID" id="87859562"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="202"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="437" mass="48398" checksum="84DA25D3A8BC50C8" modified="2024-05-29" version="1">MVATSDIPADTSASLLTTLVDEISSSATLLSSHLESRRLPWPSFSADGPPQPFPEDNEEVSRARVALIEATRSLHALAVGPVETTKHFCFNEIYLLGAMQVLCHFEIPQNVPLQGTISFHDLASKTGLSEALLPRFLRMAIANFYFAEPEPGLVAHSAWSKPLATDEKMRACVWFRHAEMLPAVSKLVDMVKRYPDSPEPQDTAFSLAFGDTFFGYKERHPENMVKFGQFVGAFSGGSSADSAENIARAYPWETLPNGALVVDVGGGIGHISASIAQAHPHLRFQVQDFEDLKGATEELMEGKGVKDRVEFVPHNFFDPQPEPARGAAVYFMRNILHNWSDLYCRRILKPIAEAMGKESRIVNCDIILPEPNSVPKTQDAMTRALDLTMLSLFNAKEKSIDEWKELFASADGRLAITDVVGKPRMRMDSLVEVRLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAC6</accession>
    <name>A0AAE0JAC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_252729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679178.1">
        <property type="nucleotide sequence ID" value="XM_062822498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAC6"/>
    <dbReference type="GeneID" id="87859652"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="183" mass="20633" checksum="F431EAADF7012552" modified="2024-05-29" version="1">MESLTSFVRRTVDDESHNDRLVNLMIALLVLVFCALLSVTILLLLKRIKQKTPGHNESLPQYHDEQKRSSNHRRLTISTGPGAPRSSVIVFKDGQPMLANPSSPPHSPDNVPEIHITFPDEQDDQGRRRSGRVLVVRLGESTNSIGLEPRQDEQLPAYEKESNSQFVSVDIEKIGGLKEKEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAP3</accession>
    <name>A0AAE0JAP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_510687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679514.1">
        <property type="nucleotide sequence ID" value="XM_062828422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAP3"/>
    <dbReference type="GeneID" id="87865576"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000027">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042169373" description="Fe2OG dioxygenase domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="156"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="296" mass="33609" checksum="9D95E0B6F496A298" modified="2024-05-29" version="1">MLSYAVALIGILIVFNSPINNLLFSGVNQNQCPGQVPQLRRIPLSKLNLKEDLIALEGNSSLQCMPHTPAPVVHVYSREPLVLYIENFLSLDERHHLLDISEPLFEPSTTTNDGGQTTHRNTTVRDSEVAVIPRTDRVRCIENRAREIQGWRDDVFIERLRTQRYRQGGHYNHHFDWSSNRGGWGRVSSFMVWVDDGDGSMVGGGTEFSRMKRRKDPRWCTFVECPEKTADRGDEQGQTPDDLGVTFKVIPGNAVYWENFRSDGTGRGWDEVWHAGLPVEKGVKVGLNIWSTGYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAU6</accession>
    <name>A0AAE0JAU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1682-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_253656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679213.1">
        <property type="nucleotide sequence ID" value="XM_062822518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAU6"/>
    <dbReference type="GeneID" id="87859672"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3340271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50216" checksum="B903C55F47B4923A" modified="2024-05-29" version="1">MANVINNLFGGAKPASVIPDKAGDSDFADFAEGADPSPIPISPVTTTLAGAQPAKTVVPYTKWYNVHERHSLSEFKAEGFILAAMTVVLVLHLFGARLNRSKAKKWIRAHASTLGSEFALVGFSGVPRALSDKSGDKLTQALADSNSQKGDGILKEKSLFEFATYATGRVNVAFVDVKLTLVKRFNPFITLAENVIGFFWDSYAQPTDSVEATLYPFDGKEALTVPAMPGAAELRQNDKKSTFDGFVWAIVHKESMKQVRDERYDVSLTYTKDNNKLPQWLTVMTESAEITDALLTPELIKAAESAGDLLEYLIVSDQPIDKPTTVEETNPRKRIFLKYRLPSDNNYEPLLPIFQYFLRMTDQLVQVAHFRPEVLRKVKSVRDEMIKGIKKASEQEKAEELAVEREKQRKAKRDAELAAMDAKSQKKYLEKEREREAKRQTKKMTTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBL6</accession>
    <name>A0AAE0JBL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_430069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679935.1">
        <property type="nucleotide sequence ID" value="XM_062824860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBL6"/>
    <dbReference type="GeneID" id="87862014"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000592">
        <property type="entry name" value="Similar to saccharopine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="439" mass="47719" checksum="E583469036FD43AE" modified="2024-05-29" version="1">MPLKQHGRDYDIVVFGASGYTGKYTAQHIATHLPTTLKWAVAGRSRSKLEAVVSRLKELNPDRLPPSIEIISSTTDRTALEFLCRRTFILLTTVGPYGSLGEPAFAACAATGTHYFDVTGEVPFVHKMITKYSSAAAQSGAKMFPQIGIESAPSDLLTWSLVQQLKREFGPQTKTGEVTLSIHTLRSAPSGGTLATVFTILENFSLQELREAHKPYALSPVPHPNPDLAESRTSWTTKLTGLATTPILGLGTTSVAAKTDAAIVERTWGLFESQSSKNKEESSYGPRFSFKQYMKPRNWLSGIAIHFGLMVLGVVMATPVLRGIAKKFVYQPGEGADEEVARRDELEFWGVAKPDFEGEGKGDTDTKDTKKRVAFGRYTGVLLAEAAATLLEEESGVEEQLGGSGGGGGIYTPACLGQPFIDRLDKAGFRFETKIMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBW2</accession>
    <name>A0AAE0JBW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_550915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679402.1">
        <property type="nucleotide sequence ID" value="XM_062829770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBW2"/>
    <dbReference type="GeneID" id="87866924"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="101" mass="10457" checksum="19E491FAFBAE0A18" modified="2024-05-29" version="1">MSEGTAPPARIAGAGSGGKFVPLGDGGDGGVEAGASWLSLAGIVTTFGDGALEVFRWLGRRVYRRSSASSAGLYPRLVRLVILLGEVCIAQVIILRLITRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCB3</accession>
    <name>A0AAE0JCB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_429593</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680295.1">
        <property type="nucleotide sequence ID" value="XM_062824833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCB3"/>
    <dbReference type="GeneID" id="87861987"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="170"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3342502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="315" mass="35997" checksum="28631BC98C835A41" modified="2024-05-29" version="1">MAATTDVKNYKFNHSMIRVKDPKESVKFYEFLGMSLLKKLSFPEAKFDLYFLGYDAPGAVSSGANLWDREGLIELTHNYGTENDDSYKVNNGNVEPHRGFGHTCISVDNLQAACQRLEDAGYKFQKKLTDGRMKHIAFALDPDGYWVEIIGRKPVEETEGLKETDLKSYRMNHTMLRVKDAEKSLKFYQDVLGMKLVRTHEAKEAGFNLYFLGYGDAKGNEADREGLLELTWNYGTEKDENFSYHNGNDQPQGFGHICLSVDSIEAACERLEGLNVNWKKRLTDGRMKNVAFVLDPDGYWIELVQNERFTGQSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCF6</accession>
    <name>A0AAE0JCF6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_219918</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680258.1">
        <property type="nucleotide sequence ID" value="XM_062822037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCF6"/>
    <dbReference type="GeneID" id="87859191"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001064">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="582"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="284"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="432"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="950"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="967"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1105"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1149"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3342465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1191" mass="131010" checksum="FBD85965D82609D9" modified="2024-05-29" version="1">MADEQLRAEELQQSVMMSEQQVEASTGDGDVAMVNQVTITSEISQINAQPEPSEADEDQEMHDAQEENDHHDEEMGEGDDAEHSDEGSHDGHDDHDDHEDSGDEHGEEEEHDGEDHEGFDEDAEGDEGDSVHSEEHTSQQHLPSVEEDHEDDEDDDDEGVGAVKIKPGETDHSESESEEEDDHSSASSASVSDAESEDEPHWEDAAEHEPAGDEDDDDEGSEKGDSGLCMFCKQDEDHDPAEEFEEYLACSGCGENAHQQCAREANALPSDQAPDTWKCPNCASEGSQTAAGKNHEPTQVNGTETTTSTHPTTRRASAPKLARDLLPPQKHTNPDSHSVFNQLVLDEDPMDGSRVLRKRKTSSVEPTEHVIGLRKRRRNTVGTELEEEPNDSTAGQDEQARPTSARSLRIKISNPTAPVSIVKKTRSSILLRMRVDPTKLQQITSQPPKGNSKRSSRSARSGRSGRSGRSGRKTSGRSGRSRRAAAAEADAMEPSTAPFASASYTQPFYSFYDKETDELKGKPYGGILTDAEADTSKTLPQPEDRRRFDEAKQMAEEEWRQRLLKMQAEVEAPVKKSKKTAGPASQIECIEFGGWEIDTWYAAPYPEEYSRNRVLYICEFCLKYMNSDYVAWRHKLKCPAKHPPGDEIYRHGSISVFEVDGRKNPVYCQNLCLLAKLFLGSKTLYYDVEPFLFYVLCEYDQYGYHFVGYFSKEKRASSQNNVSCILTLPIHQRKGYGNLLIDFSYLLTRVEQKTGSPEKPLSDMGLVSYRNYWRLVMCKYLLEHCSGDPKEKKGLSIKKISDDTGLTPDDVISSLEGLRCLVRDPQTQIYAFRVDLPYCREYVAKWEAKNYVQLEPKALTWTPYVMGRSNATNFELGPALNAIAPREDEEAKPTVEEGTVIDGDASQPEGLATQVQKMEIDTSAPTILESTEPNELGIIQPEVISPRSVLKTNGLFPNGSVHGSVHPNDDHDRKAKTEPDADGENKENPDDWMAQYEGIPPTRFEVVPPLNTSRRGAGGDRIRNTVPRPPAVRTNSGSAARPRNPRRTSGVRRVSSAAKPRNSSSSSKRKAGGTGRGPGRWPKGTKKSDYGNAESGPGFPPGWLEKQKSLEGTTPKKEGEEGMKDTVHVTPTAESAAVSSSGGSGSGSGSRSASSSGANGNGEDTGSADNGNSINGGGDEQADITMKDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCI9</accession>
    <name>A0AAE0JCI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_467956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680131.1">
        <property type="nucleotide sequence ID" value="XM_062826934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCI9"/>
    <dbReference type="GeneID" id="87864088"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF4">
        <property type="entry name" value="SIRQ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="2">
        <location>
            <begin position="8"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="417" mass="45307" checksum="93478D63D623D12E" modified="2024-05-29" version="1">MADSSNHAIVFGASGLIGWAIVNQLLRSYPRLSSFLKITAVTNRPLNTSESLWPTDSDQPDLQLVSGIDLCKGDGATLADSLKQVVKDIESVTHIYYLVFQAVEDDIEEVATNRRMFQNVVDAHTILSPNLQFVAFPGRTRGYGIYTPGGTFTPPLAEDMVKNLPPDYAKTVVYLVYRELLSAASEGKRWTWYEVCPDAIIGFTPNGSQFSLALHWAQYLSLYAYNHGVGPFATEAATSPVEVPFPGNAASANSLFSPVSSATIARFMIYASLHLGTCGGGHLFNVADNETPCKYGEIWPHLAKWFGLVGVGPVAEKASAPDNSMGVGELPESTSLLSPGEYVTKYRSIFNQNGRENAATKGVGAGHRQLDSVGYWLTFDRQLSVTKLRGTGFEGDKDPVQGWLSAFGMFRKAGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCJ0</accession>
    <name>A0AAE0JCJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_589699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680489.1">
        <property type="nucleotide sequence ID" value="XM_062831043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCJ0"/>
    <dbReference type="GeneID" id="87868197"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="144" mass="16409" checksum="9757EF30D73DED31" modified="2024-05-29" version="1">MPRTLATARGRCPQKAALKEQGINPNKLLSSSRVTPRRMTAESKPPRPRCRQTTEKIFQFALGEVHASDKSFQTESVPQPPKEEKAEAHREVKQEVVDRKRTAEKEIPTRRTMKRKIAKRPIAKKSIAKESTVKKKVVKREGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCZ4</accession>
    <name>A0AAE0JCZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_527224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680699.1">
        <property type="nucleotide sequence ID" value="XM_062828871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCZ4"/>
    <dbReference type="GeneID" id="87866025"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="762"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="688"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="854"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1030"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="855"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3342906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1069" mass="118951" checksum="A4638ECB3DD2B905" modified="2024-05-29" version="1">MATPAAPEGAVAADHRPALTVEELCFASAMSCFEGWLKMDPAIGPRTMSYVTKFISRTLEKTHNLKEVRETLSRSVEVWVWLTKSFAAALPSLTTRSIGPLQSLNDPEKGVTPQESTALITKNYTSLKEDLQLLIKLMHIARNLLVVPEPEIPQDLCAAAQFDKMLYQTITLCVNVTSKAYDGDILEETARHKLSEITELYKKLLITCLQQAHNWIAKNDRNKMSFWCAVLFDDESGEEQQDAGAQFADFRPDVAKMEVQNWVERNSRMCDKARQLLVDYQQNLGSRGSPPGSLPENSVLSWNWMPHVRPRADDIGEETKITPQWKEDEQDKFEQDRLYGRVSREVDTWWLKVRDPNYDEWIISMPSVEKAHQLIEGCKLSSLNRYPHSYRNDDQEGSVHSAENVQMPEHQGPEGEVRDDRHYNLPDYNDDMIEDEDVDDDESYGEGPMSGLLTEVPNILDPKQIEALHMIVKSCILDSAGISLSRAGENLQKTRCRMFLSLECGRSLLREILVFIAVWEKSEQSLIFQLTTQIVEAIHHSALIPFAWQSLRIPKDIISPAQTVLLRLVNNMFRTRLQDPIQPGSKGHLRDIKLLQFLYIQFRTRIVPECAALMHLQAQIRNEVCDPADFPVDSWDMERAKDGLQQFLDLLMTVNEPIEWRTCLIQWEAVFDLLVLLKSLESAVPKKPMVDLPDRSAHRRPPPPHDDDRDHDYDSADPPPPPPPPPIQEHAHKFPWAGIKGQILHIIAGLLQPEAGRAGPGNPVVQKQIIQHNGIISLLNCCVYDDHNRFARERVQICLKWLMDGSAEANKVLHDLVAVSPPPNLQPAPDASGLTQPVPLRVDGIAGEVKVRVKSNNPHSASSSSSSSSAQQQQQHHPSAAYQQYPPRPSSAASNDSGTTTNSNTSTSSSTHDHDHVSSQAAPSASNHNAHQPPRVHGPAPPPPPPPPALTLPSLASPLMSVSPSDYERFTKAYMNALPPLHSAATGVPGVGHLNHPMMQAVRNHGGRPEDLFKDILTLADEAARLAIGQPPFVSPSGSGIGSGSGSGSGSGSGSRQRDAEETEEEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD17</accession>
    <name>A0AAE0JD17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_224464</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680413.1">
        <property type="nucleotide sequence ID" value="XM_062822106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD17"/>
    <dbReference type="GeneID" id="87859260"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3342620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="348" mass="38249" checksum="3003BD492E441119" modified="2024-05-29" version="1">MGWFWADGNASAAAPAVPPSHKDLAASGATPPPSCPMHNKTMDALSAHKPATPAPEPTPAAAAPPSKCPVNHGAKDTLAAAAAAVAPKQHQPDHHQPAAAASEPSFLSKLNPLNYMFSSISQEPAPNQAIALPTERDPSSIPKGTGDGNWEYPSPQQMYNALLRKGYTDTDITAVESMVAVHNFLNEGAWNEIVEWERRFGKGLMRGWEIMKRGEENAPMMLRRLEAQENDPEPQPTLIRFQGRPKEMTPKAALLQVLGRINSKYATEPPFDRHDWYVSRDDNGEKKEVRYVIDFYSAPPEPTGEPVFYLDVRPAVTVTGACERLLRWGGDVWWKASGGEVREQERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDD6</accession>
    <name>A0AAE0JDD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DOPA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_428780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680593.1">
        <property type="nucleotide sequence ID" value="XM_062824783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDD6"/>
    <dbReference type="GeneID" id="87861937"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="185" mass="21135" checksum="F0700765880C6EF1" modified="2024-05-29" version="1">MPSQRPTYKSPLEGYENAPPPPTERAEDGKSLLNIQTGVLSSAYEKFPEPLDNGRRGAFDVHIYHLPNHPAQAQYAAELHSRIRREFPELRIYTFWSKPVGPHPIAMFEVNIFTPAQFGAFVGWLAVWRGPLSVLIHPNTTEKTIEEGGEMSEAEKEARNHTERAIWMGERVVLNTDLFWEVMDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE32</accession>
    <name>A0AAE0JE32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_508525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681284.1">
        <property type="nucleotide sequence ID" value="XM_062828231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE32"/>
    <dbReference type="GeneID" id="87865385"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="66"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3344671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="569" mass="62228" checksum="E95396A6C41BA6A7" modified="2024-05-29" version="1">MSDIEKGSHDKETRVDAAPAYEAGVAEDLPQEDFMTRNGLNLASFKPRRYHTGDSTEIERTMKSRHLHMIAIGGSIGAGFFVGSGKALHNGGPASLLIDFAIIGVMMFNVVYALGELAVMFPVTGGFYTYSTRFIDPSWGFAMGWNYVFQWAIVLPLELTVCGFTVGYWNQEINVAVWITIFLVAIIIINVFGTLGYAEEEFWASAFKLGATIVFLIICLVMVLGGGPKGSRYDEYSGAKLWYASGAFANGFRGFCSCFVTAAFAFSGTELVGLAAAEAKNPVKSLPGAIKQVFWRITLFYILGLFFVGLLIPYDDENLLGANPFINVNASPFVLVGKYANLTGFDSFMNVVILVSVLSLGVSCVYGGSRTLVALAQQGYAPKIFAYVDRSNRPLFSVLAIIAFGPIAYVSLAAAGPTVFDWLLSLSGLAALFTWGSICLSHIRFRKAWALKGHSVDEIPFQAAGGVWGSWLGLVLVVLVLIAQFYVAICPPGGGFNDAKGFFVQYLALPVVIVFWIGGFIWKGTSWLRADQIDVDTGRRVHDWDSINAYRAELAAMPAWRRWFHKLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE35</accession>
    <name>A0AAE0JE35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_181651</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681255.1">
        <property type="nucleotide sequence ID" value="XM_062821515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE35"/>
    <dbReference type="GeneID" id="87858669"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="790"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="872"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3344642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="918" mass="102804" checksum="1862B77462C01151" modified="2024-05-29" version="1">MYVKKRDGRQERVQFDKITARVSRLCYGLDMNHVDPVAITQKVISGVYGGVTTAQLDDLAAETAAYMTVTHPDYAILAARIAVSNLHKQTKKQWSLVISDLYNYVNPKTGKHSPMIAKEIYECVMRHKDEFDSAIVYDRDFNYQYFGFKTLERSYLLKLDGQIAERPQHMIMRVAVGIWGDDVERVIETYNLMSLKTFTHASPTLFNAGTPQAQLSSCFLVDMKEDSIDGIYDTLKTCAMISKMAGGIGLNIHRIRATGSYIAGTNGTSNGIVPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHADVFEFLDLRKNHGKEEVRARDLFLALWIPDLFMKRVEQNGQWTLMCPHECPGLADVYGDEFEALYEKYEREGKGRKTVKAQKLWYAILEAQTETGNPFMLYKDACNRKSNQKNLGTIRSSNLCTEIIEYSAPDEVAVCNLASLALAAFVDYENASYDFKKLHEVTQVVVRNLNKIIDVNHYPVKEAHNSNMRHRPIGVGVQGLADAFLALRMPFDSPEARKLNIQIFETIYHAALTASCQLAKEQGTYATYEGSPVSQGILQYDMWNVTPTNLWDWTALKGDIKKHGVRNSLLLAPMPTASTSQILGNNECFEPYTSNIYQRRVLAGEFQVVNPWLLRDLVEMGLWSDNMKNRIIAEGGSIQNIQSIPKDIKALYKTVWEISQRTIVQMSADRGAFIDQSQSLNIHMREPTMGKITSMHFAGWKMGLKTGMYYLRTQAAAQPIQFTVDQAALKATDDQVAPAHSGLKKRAPPAGTYTSIVLRENSAAPRPYAQTGVSGTSTPNGTKDVPTPTSTPPPTAEATEATEAPVQSDSRPRPLVSPPKNAGFKADLPEPESPKALATEPIVKTEDIGSPVLEKKEGQNEDKDDESKMRDEDIYSMKAIACKRQHYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE45</accession>
    <name>A0AAE0JE45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_181888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681270.1">
        <property type="nucleotide sequence ID" value="XM_062821521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE45"/>
    <dbReference type="GeneID" id="87858675"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="273" mass="30327" checksum="F291449EA5B1C2B7" modified="2024-05-29" version="1">MEQAQARYWQISGNNLFAQWQLGKLKTNRRDILSWRHDYVVIALAFDTSDVSIVGLNNPPARGCSVCQNPALTSMLENSSSLSYVRLLFSVISSKTPTSFSHGLSSFVPAPSHPQSPTTFSRASQTTCHVIPPWPGKTDWIWCFSCAPVPDCDAKPSPFHLFRSPFGLIHTRQCQPGRFDFNLRKGDKSKHPPALTPYVTQTTYLFVTPLHKHAEATAMTRFMALGLPASSSSASSVEKRPGHGRGMPCPHPENRNTPIHGENRNKILEMKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE68</accession>
    <name>A0AAE0JE68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_464171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681310.1">
        <property type="nucleotide sequence ID" value="XM_062826750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE68"/>
    <dbReference type="GeneID" id="87863904"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="102"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="645" mass="74139" checksum="E6DC4205AA60A0BE" modified="2024-05-29" version="1">MVPGSWCPRFLPPMGYNDQDPERNVLLLKDWLDNCRLNHTKCREIKKTMETGTDFLPTRLLDVQAFGTGSKSLSYLGNDVRLVSLSPTTGPESDMNKFPPPYFTLSHCWGPPEKRPTTTTKANLAQRMERIPLFELPRTFQDAIEITRKLGHRYLWIDSLCIVQDDEQDWAHEAGLMAKVYSHSSCTLSALSSKDSSEGLHLEPLDEDRSYMDLMITSHASPAGGSGTKKSDMDDPFFFRFRMFYSLDHWDTLYNGKIQLGLCDDISPLRSRAWTLQERELSRRIIHFAKNQALWECAELKATAQRPWHHSVYPALDPEQEWKEWAGIKKSLESLSLLQDRDGNPVHVAAAAVTASSLLSAYRGEHEWWEMVFDYSQRLLSKDTDKLAALSGMAQFYQRNHFPHARYVAGLWSSRLEEELFWEVDDRTSASRPAEYVAPSWSWAAVNGRVSFRPKDPVWRFQSMRKNILAEAEKDPANPVDAKDKDRDRERDPRKVICEEWKVEEVNLLPRYDDQYGALKGASLIIGGARLVEVKLFTETLIEPDPEYIQGFHRHYGGLKIDGRWVADHRLDVEGEVEQSGCRLWCLGMVAEKHYRERPVIGGLLLREERLDVDGDLCVYSRVGKFHNMAVALFDGVEPRRIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEF5</accession>
    <name>A0AAE0JEF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_492909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681278.1">
        <property type="nucleotide sequence ID" value="XM_062827759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87864913"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="393"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="456"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="473"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="509"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="540"/>
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            <begin position="555"/>
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            <begin position="973"/>
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            <begin position="1067"/>
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        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="1107"/>
            <end position="1140"/>
        </location>
    </feature>
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        <location>
            <begin position="1141"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1346" mass="151507" checksum="E2D435DF5B7528EC" modified="2024-05-29" version="1" fragment="single">MDRNMDPDVDMMDIDDDFSDDELDAYFQAHGLDEELGPYRRVSSQHRPQERVEQQWQPPPPSAQREFESSDLEQNYRGGNSRWKRKGKADRGETAAVDDELELDTYFQAHGLSEDLEPYQPEDDRPPPSYQPRPQRQPPRSSGLKNSRWKGKGNAVGHGNAAGLGNPAGFGRGDVLGRDGGARDGGKGKVQAWLLDEGDKDGDDDDERDGEAVYLYPGAPPGKSGRPQRVISPSPSPDPTLGSSPPVLSGLSIHNKDNDDTAPPGNKKTAASQTREEEGQGEAAPIDDPYDSEVSIAARPIVSHDPDYPNRPIDSDVKAARGVIRHVLVSEKFPEVWPDPEAEAEAEEEVEGQQKAAESGKVVVEGVKVVEGQKNGPEKEKESKQGKQLGQKALEKEKEKKGADNSKEEYTEKKKEVVIPKGVVMLVRGIQFLKMPPDTPSGSEVEVCSQYGYEGDSQQRGSSTPPSEFWSDEELRAHGNEGQKHERVRDDDDDSEHSVERPWKELPQQEIQETDLSASNSQPSSTNNDSDIPMTNADYLPPPSSQIPPPHSQPHRQSQSQVQSSISLKRTWSQRQDHDHPSSPSSPSDPDPDPYHDDLYNQNLPPPLRPPSSSSSLPSQPPTGPPNLLIRLLLDDGEFWVQAILRPEFHHLVLGYDFDEWASDSDSEPEDDLEEGEGAKEEEEREQEMQEKWQTKWEEKARGEVREGIYVRLVGEVVVEFEEVDVDDELQPQPQPQPMKNDQGVSKGQEKEKGFNEVNGRQAGGVVKGGVKERGERMHIYDDGIGDPEKMEKLKREAMERKWLGKGKEDEGLAKVENAGAKTEVENPKTGKMVCLVVGHMVPVGWDRKYMREMKKAQLKAMEEELGPDSEVSSTTGDEMDVDTKDDKSKKKKKEPVKQKPWWMETGYRAELEEKRKREAQKLAKEVKEREHISDQKLQNAAVTENKRPDPRKVLPPEWANLSIFEVDRLLKEWDKQNKPKEPKPPKPPKPVKKPIITARQAPQFRSSITAQEIFQLQNPDRKPPTKAPGPVYLAAEARALRGPQEVRQAAIENNQQIQRKIKELPPRPQPRPQQEPGPRPHLQPHPLLQPPQARPQARPQAQVQPHPQPQPQLRPQPQLQPQPPRPQPQPQLPPQPPARPHFQPQAQARPQFLQQQPPPKPQPQPQPQAQPQHPPRLPPQPPLPPPKPNPHLATDPTVPLKLCSLRQIPHLPYAQNWMVNVLAVIVSISDVEPSPMPPTYTQRIVRLADQSTSKLVLLNVFLDAEEFNPRPGEVVLLMGVKNHRFEGGCLKKYWSDRPPEGCKVGWWVGEEVLGGLEWCRGVVDGLRGWWREREEREREREEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEW8</accession>
    <name>A0AAE0JEW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase family group 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_573794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681719.1">
        <property type="nucleotide sequence ID" value="XM_062830560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEW8"/>
    <dbReference type="GeneID" id="87867714"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="314"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3345106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="428" mass="48469" checksum="780318F84D15AFE4" modified="2024-05-29" version="1">MTVNSRVIKTFLQWSPEAIEVPLNDGLRIQILPTVDDLLRARKHQAKHIESALMQLVWKDGNEVDDEEESAPPMVERIVEVDAESGEPKREKRPVHLLNTYLVSITLLIVTVSLRSAWRQLAIEVMVDGDFVRLALVVLAPVQIFFTLFFAQVIVDCLAQIFGPIQQLSVNSKFYSAKLPPRLQTPTLPHVTVQCLSTKKASPVSLLPQSSRSSTPSPHRQERIEFYADHSIGWVARPRHGENGFQRRSKFKKAPNMNFALMISCKVEEKLSQIQRSPEWSQHDEAQACERALQEVLEEDGRAWTDGNIRMGDYILLIDSDTRVSADYLLDTVLEMEQSSDVGIMQFSSGAMQVVHTYFENGITFFTNLISSAIRYTVSNGDVAPFVGYNAILRWSAIQQVSYGDEDGYEKLWSESHVSEDFDIALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF30</accession>
    <name>A0AAE0JF30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_427361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="253"/>
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        </location>
    </feature>
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            <end position="330"/>
        </location>
    </feature>
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            <end position="484"/>
        </location>
    </feature>
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        <location>
            <begin position="653"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
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            <begin position="415"/>
            <end position="426"/>
        </location>
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        <location>
            <begin position="449"/>
            <end position="462"/>
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            <end position="683"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344895.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF68</accession>
    <name>A0AAE0JF68_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">WLM-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">B0H65DRAFT_539425</name>
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    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062829119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF68"/>
    <dbReference type="GeneID" id="87866273"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="174"/>
            <end position="347"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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            <begin position="84"/>
            <end position="97"/>
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            <end position="181"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="381" mass="42340" checksum="7034F3B6D6FEF949" modified="2024-05-29" version="1">MNDSEQQSQPKGAPLPLSSGEASTSYINDGDHFEITIKFAPEKHSQSWLFRQDTTFEDILMALGHQWPDYDFLKSKAIVEKRQSPSSTTTKTKSLLKTPDDDNLPMQLYAGNSLRFMAPKKSALESLHAASASIAKREAALQAQRRMAYKGGQPSASSGSRGGIHTINGPSSDSSSGDTRFTFQTIRPLPHLPNPSRSLSFLNRLAADPGIRAAMRAHQFTVGLLTEMDPGQYTASNHEGTTRILGLNRNKGEVIELRLRTDAYDGYRDYKTIRKTLCHELAHNVHGEHDRQFWDLCKQIEREVERADYTKSGRVVGGEEYEYGGPAPVNEPDDEEGAVYDHGGWTGGTYFSMRCTPVQFVYVTYPQSPMSIATLPTLCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGC8</accession>
    <name>A0AAE0JGC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_147992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGC8"/>
    <dbReference type="GeneID" id="87858185"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="644" mass="70460" checksum="A9F6F6D4592A5BC1" modified="2024-05-29" version="1">MRYDDWDVILFPTGRDGKIPIKEFKVQCHVVPDQELAHMHGQAGLPVMTCFIPSLPAGSPFQISMHAWKTPDISLFTKTYSRHTEFVKFEARIFIDGRLVASTAFDRKVNGPHLIADTFEYTKTGERERLRFPTFRRELLYESHWSPGDDLGRIKVLISEGFPRDSVTVPFERVKNVVAFSFQHAPLELLENNSIAWPNPSMWRTPTYISNIPVPTYHPDDGINSHAHSPQRGKKSSQSPGFPTPITTHGVFQPQPPNTSYGGTQTLQMPYAPRGANTSSGSSLSYPDPFTEPSYMDWIGSMGTSSWQSSMRRGTQQQSSDETMPDYGDPNRDQQEAMHVSGHSMDDEHPMSMKVPTNTPTTVPPPAEDMTTGVHFPSMSTHMPSIPSDMASCLTNTLLNQPMPLPLQPHQVPLPSSDVKSRKENRFLTIPGSNPSSAHSTPTADHSDIRKFSQPVYSQCPIASNLSQMVSSMDGAGSSSDSPSLQSMFSVAGSHQNSPRQAEFGSSSNMYGGHASCPNPPGFPPSLPSNLSSTFSSNLTSNSTSNFSTNLPTNPASGPTPFAPRTESSLNAGHGTGQSKGNGNGSDSAVGNGNGNGNIKRTRNFTPASTKAIDEEDEPRRASPHVRTRDYAKEYGLEQNMLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGF2</accession>
    <name>A0AAE0JGF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_427449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682283.1">
        <property type="nucleotide sequence ID" value="XM_062824689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGF2"/>
    <dbReference type="GeneID" id="87861843"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3345670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="895" mass="96087" checksum="CDFACE903605AB82" modified="2024-05-29" version="1">MMSVWMGAHGRCRGNLAILGCDQRGSSSPEARIVRLKTEPGTSTRQSPGPSSSSNATTAGSSNRPVQPPKVCDKCRLRRIRCDYQSPCQPCIDAKLQCTRNHVPRKRGPRPGRGRLINRLREREAGKKEEQCPSSSGDPEVSDGARSNNTDIFPQNASVSTTWASDVSIAPETTGLFANEHIFPSRGAFLYLIPKCVELFYQHLYPVMPVLYMPEIQRMDPRTCDLPEKNLLYSLSALTCFRMSGHSLGAEDSPEFWDQAGRFLLNDCLDVRKQYDLYENISLNTVVSSMFLASSFFETNQSTKAWVYLREALTFAQELGLEDESTYAGLSPEEALCRQRVFWLLYVMERSFAILRNKPLMLRRTPKLPMTLHAYESRGIHTGFLQLLGIYIPLRDSIIEAWTYGSHPTVDVNTYLALQNQLARPAGSSGGLSIPHPLLPPSPTIAVSSVQIPVTQACGFSDLSLSSSSISSSPTDPVAPVAEPTPSQTAELLVTQQWLRLIIWLSSLRQGYLSWAAENESMHFAFPLTIARQTALVLRSLLQIGLEANGMAALEVNGIGIFEKIFEIGAWCMNVLDSYDKASLEGQFLSLPNFGRKHSACSGKGKQAARSATNSPAEQTMDYEEEDDVDLLDVFMRALSATPTSRKQFAEPLYMWATTRPGGMRIRSSPGLHPDTGGGAGAGAFGMAQTQPGLAGQIPGLGPGQGLGLGQASGIGAAQGHNASSMMHQQQQLQQQQPGIWSAASAHAHGQAPLAGSATGSGAGLARPSGPGPGGGQGQGMEDVVMGDQPSHQGQGFNIDPRLGAGSNAPGGLQFARQPLRPNAPHLPSPLPGQFGGSPTSLYNVPGWSPIDPGGLTRARSRTMGMGQLKGLMAMVQGGPGTPGSSGPDSSQAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGY4</accession>
    <name>A0AAE0JGY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_152432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682749.1">
        <property type="nucleotide sequence ID" value="XM_062821095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGY4"/>
    <dbReference type="GeneID" id="87858249"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041781701" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="36"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="578" mass="62176" checksum="1AC3615B3EC8B42F" modified="2024-05-29" version="1">MKGFSNALLATSLALLGRVSAAPAEPPTQVLDKRAAPTVTISTGTIVGANGILTEAFNGIPFALPPTGNLRLKPPVRLNSSLGVFDASGMAPACPQFLADTSSNEFLPQVIDKLINTQLFNTVFNIKEDCLTITVTRPKGTKAGDKLPVLFWIFGGGFELGWASGYDGAPLVTNAINMGKPYVYVAVNYRVGGFGFMPGKEILKDGSSNLGLLDQRMGLQWVADNIAAFGGDPDKVTIWGESAGAISVFNQLSLYDGDNTYNGKPLFRGAIMNSGSMVPADPVDCPKGQKVYDTVVKNAGCSGAADTLACLRALPYDTFLKAANSVPAILSYTSVALSYLPRPDGKVLTQSADKLVLAKKYAAVPMIIGDQEDEGTLFSLFQSNITTTSKLVSYLNDVFFHDATESQIESLVSTYTPLLSAGSPFGTGILNEIYPGFKRLAAILGDLTFTLTRRVFLDAATSLNPSVPAWSYLASYDFGTPILGTFHGSDLLQVFYGILPNYASKSIQSYYANFVYNLDPNDASGGTSSKSKVAQDWPQWQKERKLVQFFSNYAGYLKDDFRSDSYNYIKANVDAFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHF7</accession>
    <name>A0AAE0JHF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_575020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682357.1">
        <property type="nucleotide sequence ID" value="XM_062830607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHF7"/>
    <dbReference type="GeneID" id="87867761"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="497" mass="53674" checksum="9D895303730A5B3F" modified="2024-05-29" version="1">MGGSLKLRKVFGLKPKSSSANLQPQPITPDNFNSNDLNANGIYSNNGGYHSYTPNGSSAFSSNNSGQAPGLSSISELPANEYGNGYTHHAPPQHQGQQHHRGHDHNRMSLPVQARPGPPNPQYPHDPNAYYQHHDRSSGNLSPQDAVHQSGGNRDRRSASLGSRLSLSNFGSTSSNSSLGRSSVTTLSTMSSAATSPGPGPGPASPHHLSHTQSQGYLAAAQPNSPRYPGQPVHGQGHGGQPQPQEHEQAAAKHRNFTNPLSSSRHRTTGSQQYPPQTQTQTNVLHKHEPAVQPPYPVSERGSPPPHGHSRSSGSHSQNLQSFAHRTSLHPGIPKSSSNSHPTQPQPHNQTQTQAQQQTPSAADIRRTTKLLRRMFELRLEQWALSHSHESDQHLVHEKRGQVDAVLADILGNVRSWGTGGRENWTEEEWDDVCLVRDVLGEMSAPGAPGGLSEGARGQVRTTVASKVDKRAVTNRSGASDEEIEESIRAIQRTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHY4</accession>
    <name>A0AAE0JHY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_169240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683295.1">
        <property type="nucleotide sequence ID" value="XM_062821344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87858498"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000175">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000114">
        <property type="entry name" value="Cell wall alpha-1,3-glucan synthase ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042194159" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="2374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1984"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2008"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2043"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2075"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2115"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2159"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2198"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2300"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2347"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="74"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1415"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1660"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1865"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1436"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1880"/>
            <end position="1889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3348213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2374" mass="264805" checksum="0F0B9A1E521AF50E" modified="2024-05-29" version="1">MTRLALFSIRALFTLATTFTLTDALRYDATQIDYNLNRNKTATNPLDYWGDRTEDDPNFKYHPSPKSWRVPFYTVFVDRWVNGDPDNDNANLTLFEADIMSNQLRFGGDVDGIIDSLDYIQGQGVKGIYIAGSPFINQPWGADSYSPLDLTLLDRHFGNIKKWQEAIDAIHAHGMWVIMDNTMATMGDLIGFEGYLNTSTPFLTEEHKVLWKSDRRYLDFDIGNTYNQTCDYPEFWYEDGKRIKPDGLKGCYDSDFDQYGDIEAFGVFPDWQRQLAKFASVQDRLREWKPDVIARLARFSCMTIGMLDVDGFRIDKAVQVTVDAQAHFSSAMRKCAKEKFDKDNFIIVGEITSGNTLGSIYLGRGREPEPAEELSEDPQKALTLGNSTTDVSKYFVREKGNSALDAGAFHYSVYRFMTRFLGMSGNLRAGYDLPTDWIETWQEMIATNDFWNANTGEFDPRHLYGTSNQDVFRWPAIEKGTERMLLAYFITTFLLPGAPLMYYGEEQELYALDGTASNYVYGRQAMAPSPAWMAHGCFSLENDLYVDWPATKALNGCKDPSVGWDHRNPAAPVRNILKNMFALRNSSELGVLEHGWLLEKLSNQTDFTLLKGSGDPTERGIWSVVRGLYPGVQDALKDKPVWFVYHNRENTTTYKFNCDQREGAFLSPFDAGSQVKNLMDDGDVVTLSSSNVKNNYTNSGKNMGCLPEVTLEPFEFRVYVDDPADRWMQPAPMITKFTPGHDRPIDSTTLVNGRQEISFEFNTEMDCDSVTKSLTVNLTQDGVNDPTPLSWTTPVCGNFTPQDEDKVKYTGAINSAWKWSTNLTNVADGIIKLTVGPNAASKLKVATGTRDHFLLRIGKPVNPVVWGMGATYNWDLLQSVSGNMYKIKHSAPGATKWRYSTNFGSTWSGWVNYTGIDTPVTAQQWSGTDLQAWEGQHIQVQYFSKPLGSSAFIQHSDKGVNYQRVQPHIKLHGPFNKWGYDTGLPGSMDLVGDNTWSLHYMYEWPANFQLNIWGINADNQPDVSFIFGDIDGDHVVDRLPPSSLANNVINITDPPPMPALAWKVYYNDATWTYHLEPAGNMNVQIALFWLFAILPVALACFAGWIYVTSFYQVKVNKSGFAAKGWMPLKIGNLSKLNLGGGKGVEMNSITPPPPSSALSPLGAAGGRRTVLIATMEYNIDDFKIKIKIGGLGVMAQLMANALNHMDIVWVIPVVGDVHYPLEKMQKADPMYVDVMGQPYEIEVYYYVVKNITYVLLDCPIFRKQTKADPYIARMDDIESAILYAAWNSCIAESIRRFPVDIYHINDYHGAAAPLYLLPQTIPICLSLHNAEFQGMWPMRTPEEAKEVCEVFNLPPEVVKDYVQYGSVFNLLHAGASYLRIHQRGFGAVGVSRKYGDRSLARYPIFWSLKSIGQLPNPDPSDTADWDPSQDANDQAKGVEVDQAAEEKRGEYRRQAQEWAGLEVDPSAELFVFVGRWSLQKGVDLIADLFPSILEKYPKTQLIAVGPVIDLYGRFAALKLEKLMQKYPKRVFSKPEFTSLPPYIFTGAEFALIPSRDEPFGLVAVEFGRKGALGVGARVGGLGQMPGFWYTVESMTPSHLIQQFRQAIESALACKHNKRAVMRAWSAKQRFPVAQWVKQLDDLYSESIRIHIKEQKKKKMEVLSPGLSVPGASSRASYADPGSGRSSPGPLTGPSRPVTPTLRDLASPDLPTPGAPWAGGRSESPGARDSTASSIGGNFYLQPNGARESTMSVDSFAIRAQNGGPMSPGLAPDGGLAFPRPAFTQAHRNSSLLSLPDVVGDRHDLKLQKVDQFFNDTNGEYYAEFEQMLEALTASNSSSDLCIETFLKRSEKEWFARYRDAKLGRHRDASRMGRSPGGSRPESRNGDRSESVVSRGRQPMRSATPSGLARSVFEESPPGGRADYDDEFLLGDGYQAPTGLKKLLSVRIGDWPLYAFPLALGQIISVNSYQIVLLSGTQAQTPEKLYTVAGVYIATSLGWWGMERNFKSVYALSLPWFFFGLAFLLLGIAPFIGDWKVADSVTSAATAFYAAGASHGALSFALNFGDEGGAPTRQWITRALIVSGIAQVYSLGLWYWGATVSSEAQTMSKFIGESSVPLAVVICVPVAIFLWAIGAVLYVGLPDFYRQSPAAIPGFYISLYRRKIVPWFFVMIILQNYWLSAPYGRSWGFLFATQFIPNWGIFLMALGFFVVLWSIVLYGFSYFSDEHTWLLPIFAIGLCAPRWAQEMWGTSGIGWYLPWAGGPVGSAVLSRCLWLWLGLLDNIQGVGLGMMLLATLTRQHVLTVLLGAQVIGSVFTMIGRATSPNALSPNTTFPDFSQGLYPGVASPYFWVCLLFQLIIPVGFFKFFRKEQVAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI42</accession>
    <name>A0AAE0JI42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol-glycan biosynthesis class S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_461917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683051.1">
        <property type="nucleotide sequence ID" value="XM_062826620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI42"/>
    <dbReference type="GeneID" id="87863774"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3347969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="562" mass="61258" checksum="6262EFB20D6D890E" modified="2024-05-29" version="1">MSARQPTDYGAAGDTLSAETQTATLTSTPMATPALPSTRKEPPPEKLSDIRRRIWVIVSFWLIVLLLGLPIWWKTTTIHRANLPLKDMLDWADGKACRPVFPLRISIQANSLQEHEAQNLLRLTQHALDDLNDFSGHHLRLQLSSPAAAQKRNDEPDTALTIRLLPGEAVTATLDPYEPVLDITYPPNAAPSATSASSSLATYVAGQLRSTFAEEQAIISYLLSSNSIPTDYRPQGLTPEAAESLAKRTTRSLKYAPTYHLTFSLFTSGPLPSSWDIEAAIQDYMKPVLDLLSPIHNFTIDTQVQLYASPGVQNQVLGKDDLSSFINAAEWPLSPSIGGAPTVNFIVFVGNQTIALSSQNAQDSAEGGLTTSQSWLIPQWGTVYLLSLPHDTAHVSVDALKQPLLTFTSHLLSLTGTPNSGSLPLRLSTLSRIRSADLLLRASSTLGSLARLALALKSISIPSSVADGVSKTIVHLRRACETLGEAEGLEHARIAEAEAERAFFEKSMVGQLYFPDEHKVAVYLPLLGPVAVPLVMGMLNELKAWRRRKREAAEKGKEKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ71</accession>
    <name>A0AAE0JJ71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_95082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="173"/>
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        <location>
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            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="493"/>
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        </location>
    </feature>
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        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="52"/>
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    </feature>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3350655.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJK1"/>
    <dbReference type="GeneID" id="87862575"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <end position="314"/>
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            <end position="369"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3350466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JJV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_105425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684279.1">
        <property type="nucleotide sequence ID" value="XM_062820483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJV4"/>
    <dbReference type="GeneID" id="87857637"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3350984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="18838" checksum="07A72B3EDF506A09" modified="2024-05-29" version="1">MPTRFSKTRKHRGHVSAGKGRVGKHRKHPGGRGMAGGQHHHRTNLDKYHPGYFGKVGMRHFHLLRNHQWAPTLNIEKLWTLVPAEAREKYISGAATETAPVIDLLSHGYAKLLGKGKNKQLQRTSRESSSNNHILGRLPQVPIVVRARYVSAEAERKVTEAGGVIELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK84</accession>
    <name>A0AAE0JK84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_110368</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BZZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684490.1">
        <property type="nucleotide sequence ID" value="XM_062820564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK84"/>
    <dbReference type="GeneID" id="87857718"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000161">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000296">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="393"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="560"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="666"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="620"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3351195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="724" mass="80537" checksum="08D2CA8F6E403E34" modified="2024-05-29" version="1">MQDGFKPANVYVANNIAFFDDVQAYFRERSAAEKRYSAELSAIAKKYYDKKAKKSTSLSVGDTPTMTPGSLESASMTTWSTILTKLELVASEHDRLANEFITKIADPIKEVAMKLDAQRKRQVEYAEKLEKEKEAQYAALQKVKTKYDSVCQDVESKRKKSESAFDKAKAQSSFQHQLQEMNNMKNTYLIAINVTNKQKEKYYHEFVPEVMDNLQDLAEFRTMKLNGFWSEATQLEFSMLQNCSGEVDHMAKEIVRNEPQLDSMMYMQHNTGAFQEPPDKVFEPSPVWHDDDSMVTDEPAKIFLRNVLNKSKGQLGELRREVDKKRREVEASKRAKQRVLEGTEQTQDEFMVLSQLFLQQEDLHQVDRKRLTAEVETSTITSAVGDVTLGAKSHNFKSQTFKIPTNCDLCGERIWGLSAKGFDCRDCGYTCHSKCEMKVPAECPGELNKEERKKYKQERQELANTLLKPTASSSHVNEMPDLTRSNTASSVRSGYAASAQRSISGPISPGDDTPPDVPNTRPPAALPTPSSVPRTNRILAPPPPTFISELPGSAPNGGGHQEQKAKMLYTFEAGAEGELSVPEGRELVVLEPDTGSGWTRVRAGYKEGNVPTSYVEILPPSTPTALVPQHTGQSGRPPSTYSNSGSSIAASTKKKGPAVAPRRGAKKLQYVEALYDYQAGSDTEHSMTVGERFVLIKEDQGDGWAEVEKGGVTKSVPANYVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL09</accession>
    <name>A0AAE0JL09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-xylanase</fullName>
            <ecNumber evidence="11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_125841</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684865.1">
        <property type="nucleotide sequence ID" value="XM_062820736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL09"/>
    <dbReference type="GeneID" id="87857890"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042076337" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="44"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3351570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="379" mass="42609" checksum="390CFADBF9EEDA50" modified="2024-05-29" version="1">MRLPFPTLAALLPILTPLATAQLHHYATLAGLKYFGAATDTPGQRERAGYEASYAQYDAIFSDPSEFGQTTLTNGQKWLFTEPSPGVFNLTEGDIVTSLAAKTGKLLRCHALVWHSQLAPWVEAKNETEWTKEELSAVIVRHIRGVMGHYKGKCYAWDVVNEALNDEDGGYRQSIFYKVLGEEYLRLAFATAAEVDPAAKLYYNDYGIERLASVKTEDARRLVKMLRDAGLRVDGVGMQAHMHADNHPTAEDLEETMRGYVKAGVQEVAFTELDVRITIPVNETSLEWQKDGYQKVARACVKVKECVGITLWDFYDPFSWIPYTFPGKGAGLLWFEDFGRHPAYQGIIDTFKELIKDKTGKCGRRLSRVRRATLPRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL42</accession>
    <name>A0AAE0JL42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_132259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685020.1">
        <property type="nucleotide sequence ID" value="XM_062820821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL42"/>
    <dbReference type="GeneID" id="87857975"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="205" mass="23382" checksum="92425B8EE5FF9CA9" modified="2024-05-29" version="1">MRAGTTSSSTGYRVSSTANTRASDMQIASHTWLLQRSRRQDTHQPTSCLSPLGKWPRVWSEPSRRIPNMITWRSSRTICQATLFQTLALVAHEHTNGHKPRSLRTRVTSSPSTPRFLLLSDCRLYPAKPSNHQDNFPTPPYSLHRVPVSRPGPCRRMGSSQQSFVFLPIRWFPRAMPVRSRHTNRTVHTQRPFPVGDPLCTLGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL68</accession>
    <name>A0AAE0JL68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_546708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684987.1">
        <property type="nucleotide sequence ID" value="XM_062829459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL68"/>
    <dbReference type="GeneID" id="87866613"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="71" mass="8260" checksum="B89736EFD40D8923" modified="2024-05-29" version="1">MAGLVNAPNRVPEKQRFYQQAYKNHTRLWKIGPRSGIIITTFNIAMWGTFGASMYAMSRKVLGYNTWFQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLC6</accession>
    <name>A0AAE0JLC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_458276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684853.1">
        <property type="nucleotide sequence ID" value="XM_062826395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLC6"/>
    <dbReference type="GeneID" id="87863549"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3351558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="128" mass="13682" checksum="7F9215547A91BF9A" modified="2024-05-29" version="1">MAAGLKTIIALSFVLAVGFLLVILSCALWKAYYPLLVVATYVLAPIPNWICSHCANPDDFVESSGAAVLDLGRFCTGFLVMMGLALPVVLANSAIITVPAMIMSVIGGLLIYGTIISFAMFFQEEQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLQ4</accession>
    <name>A0AAE0JLQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5S rRNA binding ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_507284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685259.1">
        <property type="nucleotide sequence ID" value="XM_062828129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLQ4"/>
    <dbReference type="GeneID" id="87865283"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="6">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3351964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="301" mass="34437" checksum="27938230B239F859" modified="2024-05-29" version="1">MAFHKLVKNSAYYSRFQTKYKRRREGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNRDIILQIVSSEITGDKVFASAYSHELKAYGIEHGLTNWAAAYSTGLLLARRVLKKLGLDETFKGVEEADGEYKLTEAAETDDGERRPFKAFLDVGLARTSTGARVFGAMKGASDGGIFIPHSENRFPGFDMESKELDAETLKKYIFGGHVAEYMETLADDDEERYKSQFNRYIEDDIEADGLEDLYAEAHAAIREDPFKKAESEAPKKTKEEWKAESLKYKKAKLTREQRAAGVQERIAALREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMS4</accession>
    <name>A0AAE0JMS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_562492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685854.1">
        <property type="nucleotide sequence ID" value="XM_062830204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMS4"/>
    <dbReference type="GeneID" id="87867358"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="177" mass="19808" checksum="2A91DFAE0133B177" modified="2024-05-29" version="1">MAEQKELFSADLLSPEVQSALPEGYKLRALRPSDYDTGFLDCLRVLTTVGDITKEQFQDRYDWISRQDGGYFILVIEDTNSSPPRVVGTGALLVERKFIHNLASVGHIEDIAIAKDQQGKKLGLRMIQALDFIAQKTGCYKAILDCSEANEGFYVKCGFKRAGLEMAHYYQSTKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNQ1</accession>
    <name>A0AAE0JNQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LicD family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_414569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686322.1">
        <property type="nucleotide sequence ID" value="XM_062823921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNQ1"/>
    <dbReference type="GeneID" id="87861075"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF32">
        <property type="entry name" value="PROTEIN (MNN4), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042040097" evidence="5">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="79"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="215" mass="24505" checksum="12BF9177F09A543C" modified="2024-05-29" version="1">MLLNRLLIVTTLCSLGTSAPLEPQDAITILGTTGRKDMSGKAGDPPQKYFRRFAEKALGYQEQKAALKNLVRTFLETTRDLGIETWLMHGSLLGWWWNKQVMPWDSDVDVQVTEASMYFLATYYNMSVFHYKTPRLPAGRNYMLEVNPNFFNGDQSDRMNVIDARWIDTESGLFIDITTARYNLTHPAGEGMMSCKDGHEFRVTITISVKRSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNZ1</accession>
    <name>A0AAE0JNZ1_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_449727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686171.1">
        <property type="nucleotide sequence ID" value="XM_062825971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNZ1"/>
    <dbReference type="GeneID" id="87863125"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="90" mass="10507" checksum="F8EB208B141B344A" modified="2024-05-29" version="1">MGPAFDSRLAHFFYFFFFFLSVFFPDGVLHLLLFFVGSPFLPAFFLSFDYVRICVCACVCAYVCACVYRHVWYVFEAFCSFCLSEAGYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP45</accession>
    <name>A0AAE0JP45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1348-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_27948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686261.1">
        <property type="nucleotide sequence ID" value="XM_062822857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP45"/>
    <dbReference type="GeneID" id="87860011"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="18384" checksum="5900CB62FA629898" modified="2024-05-29" version="1">MATESKPPFPPFTAETAQIKAKAAQDAWNTKNAEAVQMAYTPDSIWRNRDTFLQGRPEIAEFLKKKWSREKGYRLRKELFAFTDNKIAVQFWYEWYDESGQWWRTYGLEDWTFADNGLMRKRQMSGNDVKIAEEERWFKEGVNVNEVTITEKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP63</accession>
    <name>A0AAE0JP63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_28917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686291.1">
        <property type="nucleotide sequence ID" value="XM_062822986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP63"/>
    <dbReference type="GeneID" id="87860140"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01831">
        <property type="entry name" value="Endoglucanase_E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037461">
        <property type="entry name" value="CtCE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041932259" evidence="1">
        <location>
            <begin position="20"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="432" mass="48383" checksum="23CFA68C0DC52844" modified="2024-05-29" version="1">MWSLSRLAIFGLSILSVSATILQNGQPRITNFPNSRIDPSSYSLTTYPRNASEISYKGRWDSRYVSWWSAPGIKFGYTGQTVAVTFGNWTSDGVLVGYRISGLDWIFTNVTVGGTHLFVSPETPGSDLTAPISPSTFELRVTNWAYRIQIEAVHVAEGEKLIKIPDYGRRIEVIGDSLASGMYTSYEGLSSWAYGLGAGLGNTEYSITAYPGICAADQDCWGNPRGQVHQWFYTSDTSYRASVMYGDNPEPWDFSKRPAADIVVINIGTNDQNSHNNVSITTYIDALTKIIQGVHGKWPKAQVVVMSLWLGFYQSGNTYLPNAPQGFVNEIYQMYKWFNSDDYLRNPIVYDGVTKKTSKTGKGTAPFVHYFNTTGIMQHNDIGPQWHPTDVGAIKVASHLQQFIRMTFGWEFYATGSEVFHETEYWNDEPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPA7</accession>
    <name>A0AAE0JPA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thaumatin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_41963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686652.1">
        <property type="nucleotide sequence ID" value="XM_062824224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPA7"/>
    <dbReference type="GeneID" id="87861378"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09215">
        <property type="entry name" value="Thaumatin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000009">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="511" mass="53938" checksum="D9F023EEAD97ADB4" modified="2024-05-29" version="1">MVIEKSPTIIAPGQKGIRKPKPDIEGHSPSTYKQHHGGSLGSYMRGALGFLLILHGQTTGVAAQSFNSTRLPTTFVSKAPIVSPTSKPPPAVAPTSKPPPAVSPTSIASSVPIPPSSTIKGTTSIASSVPIPPSSTIKGTSHPTSTPPNPTPIPIVITNSCPDTIWPGIGTQNGIGPVVGGFELAPGETKPLFVSPDWQGRVWGRTNCSFNDEGTGPSNLNGVNGNGAACMTGDCFGRLNCEFTGQVPVTLAEFNLIGGINSDQTFYDISLVDGYNLPLGIIYIPAANTTWIPPNLTNCVCIASAGFLDPPSRSGLYYTNKTFPIPWEPDQTNPTVGGWCPWDLQKYPPSKPGDGIYPYPDDSIQRPVFDPCLSACAATGNPEDCCTGEYDDPSVCTPSLYSENAKTVCPDAYSYAFDDQTSTFIIPNGGGWEVVFCPRGRSTNILRIFGEELRTIASGGGLTREILERVQNRTYIESVNPKGSSGAGMTIRPSLGALGVVPLLYMAVVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPD5</accession>
    <name>A0AAE0JPD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_563275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686296.1">
        <property type="nucleotide sequence ID" value="XM_062830229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPD5"/>
    <dbReference type="GeneID" id="87867383"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000248">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000183">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="363"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3354918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="683" mass="77178" checksum="51B7B289075610D7" modified="2024-05-29" version="1">MVLRKDQLELKLKDDEQLIRQGILRNEHPFEDSPEFHEFIHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGALADPDSFERERAVYNALNNKIRNLLLSYDYTKTADPLQAWSSHITSLLVREIPKTTDITLLTASESFHLHKFILSSRSPYFRRKFAEAPETATWKLSHSIPVEAFRVVIRYLYLGELPRDLVGPRSAATEEEVFKGIDKLCKQLEIAHLWEAVLSTTDRRLARQRHQDEVQRAQAQVTAYFRDTVLKHKFTVDTRRVRDVKWPRDNAISANCLLRADEFDEFDEGEGEDVVEPAEESLISSNGIPIGPIAALNSTNGTSNGAKKPKRSVLFPVHKAFLIRSPYFETMFSSEFMEAKETEHLHVIKVDCLPEVLEIILTFLYTEKSDCPLELALDLLYATDMLLLDKLKTKAAVAISTLGSGTSNALVDRTHGGAADELQQSPPATSTSTPSSGQQQTPGSSTERDGQPVEVEPINVYDVIHAAWDLKVQRLEDFAAKYLASRLEDYIDEEEFAELIQESASRLKRREETDTIELLDDIRYYLGERFRFRFEGDGIGEMLNEEGEIDAAQVEGLAAEAEDGEIRPEQPSDGQREVEGEEERRSTERDGEEGGGGVRTLDGKLVEDEFVSDAVNYQILLEKIDKMLDRLKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPH2</accession>
    <name>A0AAE0JPH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_563584</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686456.1">
        <property type="nucleotide sequence ID" value="XM_062830232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPH2"/>
    <dbReference type="GeneID" id="87867386"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="322"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3355078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="416" mass="46863" checksum="3B59EEDAFEC585E7" modified="2024-05-29" version="1" fragment="single">MSFANMLNRLHGQPESYDKKSKYSFGRTLGAGTYGIVREANGPTGRVAIKIILKKNVKGNEQMVLDELEMLQRLKHPHIVKFVDWFESRDKYYIVTQLATGGELFDRICEQGKFTEKDASQTIKQVLGAVNYLHENNVVHRDLKPENLLYLTRDADSDLVLADFGIAKMLDNKDEVLTTMAGSFGYAAPEVMLKQGHGKPVDMWSMGVITYTLLCGYSPFRSENLQDLIDECISGNVVFHERYWKDVSNDAKDFILRLLQPKPENRWTSQVRLAALAHPWLRGDSATNHNLLPEIKAYLTKARLRRGIEMVKLANRIEALKMQEDDPENTDMPGDATLAADQAQSRHRALSVASTTGGAADAENATAPAEKRTLSKTIKTAIFREVVLAKVREMKEQEEANKLKEEVETKAKSFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPX9</accession>
    <name>A0AAE0JPX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_395321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686596.1">
        <property type="nucleotide sequence ID" value="XM_062823765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPX9"/>
    <dbReference type="GeneID" id="87860919"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="90" mass="10523" checksum="934648D7873EDAD7" modified="2024-05-29" version="1" fragment="single">YALGWGSLAYTYLSGLFPYHQRSQGIAVEQLTGRIALFINAYINPIALDKIGWKYYLVYCVWIAVEVLTVYFLFPETQDRTLEELAFMWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ06</accession>
    <name>A0AAE0JQ06_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vta1 like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_505422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686909.1">
        <property type="nucleotide sequence ID" value="XM_062827990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ06"/>
    <dbReference type="GeneID" id="87865144"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="46"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3355531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="404" mass="42763" checksum="0F960DFEE81D103B" modified="2024-05-29" version="1">MADNITIPAALKAADINLWKCATKALQLQSVKPEIAYWCMYKKQSKAKAEHPNEDAYTDDEVGQAVVDRFAQETLDRAERVVKANKVTQQTAMTFDAAATFFHLVNIWGPADEETQQKIKYAKWNAARIAKAIKEGKDPNESNPKREEPQQPALDPSDPEVQALTGSVEKKSPPPLSVTVEEVLDRDLQRTDAAGVSLPVSPASAGPSPISEAELKLPGVPSGLTDPAPSTVSLDSDTPVSAPTHNPVNYRPEPDLPSAPSALSSYPDPDISMPDAGAAAWTPDADRQPPAPPVVPPTFAPSAPSTAAVASPPVNQPTDFYFQNPAPPAPQTPAVPSLQPVPPALAVPASTYASSQVTGGFTTDEAAMASAQKHAKWAISALNFEDVPTAVKELRKALEILGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ98</accession>
    <name>A0AAE0JQ98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_585321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687074.1">
        <property type="nucleotide sequence ID" value="XM_062830920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ98"/>
    <dbReference type="GeneID" id="87868074"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="243" mass="26561" checksum="B445A28A62EFD855" modified="2024-05-29" version="1">MASTEKITVYNVADLRATTDDALLNYLNSLGLRQSHTLLDTRLALGFSAFLLSAACFAWDYKLGFESTKQYTLIAVILYTLLNGALTYWIMFVEQGTIYAGSTKDGKTRIRVISDSKKPQQKGEAPLYKLRVDVEDVKTKKVQKIELERRFSEWFDASGRFVAAPFQTVLAQGIPLVGRLDPKRAVAAAPASGGQGMIKEQFAETPGYTAEILDAIASGLGESSTTAATGFSANQDAGKKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQH1</accession>
    <name>A0AAE0JQH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_415776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686981.1">
        <property type="nucleotide sequence ID" value="XM_062824004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQH1"/>
    <dbReference type="GeneID" id="87861158"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="79" mass="9195" checksum="54363553EC72F649" modified="2024-05-29" version="1">MGRSYDKAARATNIEPPLQWTDQTTHKYCGKTDRGRIGKPNKAQKCDDCQAVKAHQARQSQRDTDIRRQEKLEWTLSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQN5</accession>
    <name>A0AAE0JQN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MGS207 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_453632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687309.1">
        <property type="nucleotide sequence ID" value="XM_062826155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQN5"/>
    <dbReference type="GeneID" id="87863309"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46974" checksum="8BC8F06A2B3867AD" modified="2024-05-29" version="1">MAGLLSYVPLVNRLVGGEAPRAIDVPPVEVQNIETDADKRPRTLKHLLRANHVNHSILYHDLQYDNHMAHILCSSYKLGAQAPQLYDIYEEESKTLEPWKDSPSEVSEADWRDNLGDRRYQRAYVDFFEDMMVMKYKYDWKQVIEEFMFGGKQPLINGLISSLGHPLIHLGYAYEFDNRELAIEALSLASSTYNYLHKYIDDSSYTKKSSFTSTSPSELLSKVANDSRFDGLFDEAKFENVDVLFEKAEPLVLEYWNAWELSNPVEQFRESQEAAIELLVASVPPGTHSYNFFLVHVLTTSHAVRVLLPFVPVKFHINLVRQWWLLTLAAYIAVLRPKVDPDYIPQDLKGKSWNYVEDKALNGRFAKDAHYVKGIRSIREAARTWGDVHDRFLAAAVRFADDFEGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJ99</accession>
    <name>A0AAE0MJ99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_76100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676698.1">
        <property type="nucleotide sequence ID" value="XM_062831372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJ99"/>
    <dbReference type="GeneID" id="87868526"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="174" mass="19257" checksum="17DF20C814C9DA3C" modified="2024-05-29" version="1">MKPSGSSPVSERENYKYHRLVREHEREDDLITKQLWQALAEHLCSRLSNMRGLHSRLFSLTASCAVMLLAACSFVLAKPLDSTPHQRSVPNLLPKQVITPGGAPCGQNNAKNRACWKNSWNINTDYEVTNPPAFNTVNVDLHITNVTNWVGPDGVVKPAMLINNQFPGPTITAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN61</accession>
    <name>A0AAE0MN61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNA repair and recombination protein RAD5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_581983</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677721.1">
        <property type="nucleotide sequence ID" value="XM_062830833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN61"/>
    <dbReference type="GeneID" id="87867987"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16509">
        <property type="entry name" value="RING-HC_HLTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="425"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="739"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="816"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="80"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3338270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="980" mass="110203" checksum="C61BF4270C5D4421" modified="2024-05-29" version="1">MPKRPYTSDVGTVDSDRRDEARRRRLNVHSSSSGSSQPQSRSRGSSTPYVPRSTSTNGPSSSSQTSSGRRQLPWQTTPGTQSSQSRSKTQRRPSTQSRPSTQRTTSTHTTRSSQSTQPTLSSHAISSSQHRPPEHVQAIHDTLNWLSTQPDILESDDEPEVIDLTQADPGPVLEFYGHFDGKIVGVRYYNGVASPGEVVVCKREPQNQYDPNAIRVDNVLGRQIGHIPKTVAAKLAPYIHKGDLVIEGMLTGEKGAFDCPVRLYFYGTSASLQRANLEERLKKDKLVTATQLKQTRKANEEQRKRQTLELRGNGTHGFPSQTQEPEPRITMEQLAKMSEITNFRSGGDMIKSLAMSEEDLANLPMASQPEKLRAQLLPYQLQGLAWMISKENPKMPAKGSTDSVQLWQHAADGRYYNMATGFYNKSPLELMSGAICADDMGLGKTIQIISLIMTEGLGTGPTLIVAPVGVMSNWKQQIRRHVHEEHQPKIVMYHGSKRKEFAKTLQDHDVVITSYGTLSDDALVKTRWRRVVLDEGHSIRNAKAQVAQNACKLEAKSRWVLTGTPIINSVEDLHSLVKFLRITGGIEQPEIFNTVLTRPLANGELKGEALLRGLMRDLCIRRKKDMKFVDLKLPEKTEQTIRIAFWPDEQKKYDALLSEAQGVLEDYRRQSKRSQGQFQGVLERLLRLRQTCNHWVLCKKRITEVLEFLADKDVVDLTDENKAILQQALQLYIESQEECPICIDPLNNPVITHCKHVFCRDCIDKVIEVQQKCPMCRAPLSEDKLLEPAPEHSATQDEEELESETKSSKTEAVLALVKGALEKEGSKVIIFSQWTSFLTIIQHQLDEAGYTYTRIDGSMNTAQRDAAIRALDYDPNTRILLASLGVCSVGLNLVSANTVILADSWWAPAIEDQAVDRVHRLGQTKETNVYRLVMENTIEERVLDIQKEKRELVGKAFQEKQDGKKKVKETRMADIMKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNE1</accession>
    <name>A0AAE0MNE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_475005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678333.1">
        <property type="nucleotide sequence ID" value="XM_062827280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNE1"/>
    <dbReference type="GeneID" id="87864434"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042178399" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8737" checksum="D23545C7B798CA18" modified="2024-05-29" version="1">MMMMVVVVMILMMLNEGALWGSSQPPSPFLLRAPPRHIAWRLHCATAMMIDDDRQTVITSSGNLSANFSLPWLLLIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNN8</accession>
    <name>A0AAE0MNN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_476283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678737.1">
        <property type="nucleotide sequence ID" value="XM_062827354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNN8"/>
    <dbReference type="GeneID" id="87864508"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042282572" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13042" checksum="2A87053CDD46D249" modified="2024-05-29" version="1">MRTTMIAATLATLAGFTMAAPAPEAQIANRQWTPHVYVCITTGWNRCSVLDANRGQCYDLTKMDDLGSSLTGFGPDPGLTCSLFSNQDCTGDHLDYISYPGIGDLHDKGWNDKAKSYKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNQ9</accession>
    <name>A0AAE0MNQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_407486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678797.1">
        <property type="nucleotide sequence ID" value="XM_062823814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNQ9"/>
    <dbReference type="GeneID" id="87860968"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="278" mass="32342" checksum="A97CD475AA52CF9A" modified="2024-05-29" version="1" fragment="single">MRLLERDDTGGVRLTEDLPSNKIPPYAILSHTWGPEEVLFRDMTDGTGKNKASYAKIRFCGDQAWRDGLKFFWVDTCCIDKSDSAELQHALNSMFHWYRSAVKCYVYLADVSTHQHGDGSGWQPAFRESRWFSRGWTLQELIAPTIVEFISKEGERLGDKESLEQEIHDITGIPRKAFQGVPLSDFSVAERMRWIEKRDTKYEEDKVYSLFGIFDVHMPVLYGEGRQKALKRLQDKVHEDYLYLAKLWPTDPRDPHVEKERIELAKGGLLADAYRWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP31</accession>
    <name>A0AAE0MP31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_283853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678259.1">
        <property type="nucleotide sequence ID" value="XM_062822915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP31"/>
    <dbReference type="GeneID" id="87860069"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="373" mass="41932" checksum="C7F5D0701E829051" modified="2024-05-29" version="1">MSSSTQNPQSPKSPQSPKGKATSPAPAAAPTPLSAEAQDAAGILPATHWTEQPLPEEDVDDGASSIGSFTSTTASLSSSIFQYREVHGRTYHAEIGNAESWEPNDQRHVDAMEIFHHAILVHMGGKLYFSPLEQKKVQKVLDIATGAGLWVIDFADEFPNAEVIGTDVSPIQPSWVPPNVKFELDDCNREWTWPENTFDFINFRFLNGIVDDWYTLFRNAYRVAKPGGYVESYATGCRFLCGDGTLKEGCALEQWGKVYQEGGRKLGRTFAVYEEDLQRKGMEAAGFIDIEFRDIQIPVGGWHPEKEANERGLWWKLAIEGDLEGYINYLWNSVLGWTPDEAKAFTRYMRRDLNDPKIHGYFMARVAWGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPE6</accession>
    <name>A0AAE0MPE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_295271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678619.1">
        <property type="nucleotide sequence ID" value="XM_062823066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPE6"/>
    <dbReference type="GeneID" id="87860220"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="83"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3339259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120591" checksum="560D9FFF12CF64FA" modified="2024-05-29" version="1">MAADTERTILDFYQVSSLNPVEWPAEKDNNSDVSDDETAKQKANRRKSRFQALERVVSNRNSVVPGSETSASGVGNLVQRDEPDPLGTTDSVVRTLKQMGVPLQDDPKLRNRFLLSSTTFSPALFLSQVHATDSTEALLNGLEVLNQSIDQKSASLKVLVESNFERFVRAKATIDNVYKEMKYRGAEPAAPRARAHSRHASTRSTSAAGGLASPMAPMVDPRKKNALIKESEYGVMGVKAPLLDVSAKAEDFWGPALGGREKEEHLKTVGSSLDTYKDYVEISAALAESIKRKDHESLVEEYNRARRFADEAKQIAQNIGSGEPTEAQLYKILLAARMWHDVDGQIQSFKRDVWRRLVSPQAMAKSDAALGQAHDQHMDLITLLLELGVEENPIWTWLQSRVGYLKSRIQSTAERSKGEIEVLRRRLANVEKPSPQSIASNLRALGRQSIESKTPTFDSAEVLEVWETIVAFMNNLMSPHGILGEVVEFWQTVEGFIDGNTQRTLPVGYKGESQGHHRLTQQSSQELQRATVELVDMIKEHVLSFFTGPPPEDLSALVSPLPSTPNTPNPSTTPGPAIQNTTLRVPINLDPNNLPPPSPKRGEAWEKFAFWPPWSNSISGAHYLAKMLTLVGSGASDMASLAPVGKGDPSELEQLRNLMGATRERCVTALCAAWNRDSENIKYVEDWNRSPIRKDVTKMPASFAAFEGALLSGMQKILYVSEAMTKPGAEDIVLPPATKLLQMVRSQYVTTLYKALHGMVENAELPIKKPDDDWTTDANDFVLVNNPSGLRVSTIGGATLDAGDSNVRMLLTLSNLQALRSEVVPNLNTQFENAFSVKLTDETKTIRDVLGQIDARLFQSYTRPSIESLRRIIRAGVTASDWPPPPGTKPREVRPYIYEALLDLVLVHTQVSTTAASLTSQVLSFLLEQTSRELLEAFKTRARYDLGMLMQATLDVEFVAQTLNHYTTDRASELQSAVYQELDSRTDNDARTRLQSELPEMRAVLKRLREASRSEFACFRKPKKTTGPAAGSGAAAATTTGSSAGSAAMLAAQVGDMSGLERTDTRDTGRSYATLERTDTRDTGRSYGTTGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPH5</accession>
    <name>A0AAE0MPH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_473019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679562.1">
        <property type="nucleotide sequence ID" value="XM_062827173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPH5"/>
    <dbReference type="GeneID" id="87864327"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="311" mass="35600" checksum="4DAE31D68E57C33B" modified="2024-05-29" version="1">MTVDYPTNKIWSTLVTKRAYFGGALVLNHTLKKVGSRYQLKIMVTREAEADKEFMAAFAAAGIPTIVIQNIEPTRKGKVNKAFWQKLAPWAMTEYERIVLLDSDQVILQNIDDLMTLDLPEGYIACSHACTCNPRKIAHYPKDWIPQNCPFTSANHRTGSPAPITPSSPPTHHLLNSGTVVLTPSKPQFDALINAINTHPDVPHMVFPDQDILAIVYRGKWKPLPYIYNALKPMRDCHSSLWRDEDVKVLHYILNKPWESREFDEEDKVESTHRLWWEAWGEVEREWTGGEAGEKKRRLFDSVVRPVVAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPT2</accession>
    <name>A0AAE0MPT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_510305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679039.1">
        <property type="nucleotide sequence ID" value="XM_062828386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPT2"/>
    <dbReference type="GeneID" id="87865540"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30755" checksum="AF2AF4A41B069259" modified="2024-05-29" version="1">MNAIISILGKRALKSLDTDKIKPNSDNPYEERVPVYKNGQIVKYKTQERPIPVELSSNDQAILKKVRKRAYKWDQGFRLCCFPMRVGWSFFIGLIPIIGDFADALMALWLVKKASKIDGGLPATLYAKMISNIVFDFAIGLIPIVGDLIDAVYRANTRNAWLLHVYLMAKAEAVRNGKVSDPETGETIHLSGNGAGHGVLQPSTRPAQSTSAPEATHGRGWGWNRGGGGRTAEPDLESGIVEVRPERELRDNHGGRGTPESKAGDKVVLVGPTREGRGLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPU2</accession>
    <name>A0AAE0MPU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_471421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679069.1">
        <property type="nucleotide sequence ID" value="XM_062827095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPU2"/>
    <dbReference type="GeneID" id="87864249"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002000">
        <property type="entry name" value="Putative heat shock protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046707">
        <property type="entry name" value="DUF6780"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20571">
        <property type="entry name" value="DUF6780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="236"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="807" mass="89097" checksum="EA42CBFB32903F6A" modified="2024-05-29" version="1">MRSNNDASGRPRGSDNDIPSLRLPPAPQMTFCFGDESSVGPLTGNQPSSFAGPHRHLRDNKRKAHGVVEGSETHHGRARGLSHHRHNHHSTPEPEKETGASGSGSTRTQPKHQNKSYTPNQILDTLDHVIEDAVYPRPSSCTPSNDLSQAPFSPFLFSTGPASAVSDTSSRRNSICLSDDFDMASIPPSVHPDEIDIEHQNEHLDSTMMDIGSAPQLIMPSINMPSRRPFTDQGKSMGRLKVLIAGDSGVGKTSLIKAIVQSCEHIVHVDPITPSPMSPQPSLKSSVTLKGKQTKGGSRSSSRRQSSNGTGQITEVYASTKPYPQWWSEIDDLNVLKRRKSMEDTVLDRNICFVDTPGYGSGSSSMDTITPVVQYIESQMQRMNVNALNDGDMLNMLGGEGGVQIDVVFYLVSNRLRPVDIAYLDQLSPLTNIIFLLSHADLMSPEQISASKEQIQAQLREANIRPFSFSITPSKTASSSTLSPSPTDPAAQGVYAISSAAGSDHDMMDASLLMSTDYVEPLVPSELPRLVERVFSPDGASWLRHSAARKYVQWRKGLVPEKPAVPSPTSPSSVFSLSPSSHNSRPGTASSFLSRYNTSGPIGATSSYALARITDHTQREERLAQVRLANWATELQKSLANERAQYEALARNKRAVWLTEKIGECVVDGTLVPISSTSSSRSSRDRSGSNRSLSTRRRRGDTWQSIDRQQQQQEMGLFGFGYHHQGHHYRQHQHQHQHQQHRQKQRQRETDPLGLMEIADELMYKSLIALEVLGSLGVLGGLAIWMGRTMQLQPLEWFVGEWNRVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ25</accession>
    <name>A0AAE0MQ25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PH-response regulator protein palH/rim-21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_256926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679309.1">
        <property type="nucleotide sequence ID" value="XM_062822563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ25"/>
    <dbReference type="GeneID" id="87859717"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="754" mass="81770" checksum="C8D860236683A335" modified="2024-05-29" version="1">MNCASFNLPEGGILQLPNGEIITLSAPAAFKPPSCGLALRSVPNIIASGGGVGRTGSGSMGLKADDDSHFSDWRDPFYASTFPQCYALAATTIIAYTLVIMLFITPRSFLDGGVVVLGRKGFTNGGGGTSIGGRPWLQKVAALSVAISLTIANAATFRVAEQQYSWGVQNATQLQEDVLGGAELKIIRIISDTFLWLAQAQTLIRLFPRQREKVIIKWTAFALITLDVIFQSLNSFKYGGSDLTRPKFTEAVPALSYLFALALGVLYAAWVLYYSVMKKRYAFYHPLMKNMILVAALSVVSILVPVVFFILDISKPDFAGWGDYVRWVGAAAASVIVWEWVERIEALEREEKKDGILGREVFDGDEMLEASQSEHAWPKRRRKGSGGSDSQDTESGGGGKDGGSSLWRFGVWPKISNLTLKHRSEPSSKTEPKQGSSPVADTTNDDEIPRFLPPPLWPARPTPAATPVSRTDTTSAASTIYAVRYNTMTEPTSYGTPLPAHNMGRLSGSESRGSSRHRDYGSTSPGSAPTQDARSTQNSHVGVETPSAGNRWHALAPAISSRDFVTRSEPRGSKMQRDENSRWDLRARVDEFAATQAEKLREKFRPTLDTNNLPVTVIPAPPRSGAALAQLREDEELNLSSREGTVREESRNSNASGTVTAVEVTHTPTQTTFSPPPRAASSAMSTAQLSRPRLSPIVTQGSFTNNRYNHLPVTVIPAPRRQDSTRAPSQPQSPSSVALGKQPARSNSTTTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ90</accession>
    <name>A0AAE0MQ90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectate lyase superfamily protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_222635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680327.1">
        <property type="nucleotide sequence ID" value="XM_062822072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ90"/>
    <dbReference type="GeneID" id="87859226"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041960242" evidence="1">
        <location>
            <begin position="20"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="390"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="766" mass="81157" checksum="0A95B16F3620B535" modified="2024-05-29" version="1">MRFGTLLLAVAGLASAVDAYWMGDIAHRGYAPFAPSGYPVFRNVKDYGAKGDGVTDDTNAINAAITAGNPCNQGCTSSTTTPAVVYFPAGTYLISGSIKPAYFTQLIGDASSPPTLKATANFAGFGLIDANPYYTQNLNWKAVNVFFRQIRNFVIDTRNIPPATAATGIHWPTSQATSLQNIVFNMPTVSNVVHVGLFMEEGSGGFVTDLTFNGGATGASMGNQQFTMRNLKFNNCKTAIYHLWDWGWTYSGLSINNCGIGIDITAGSGKIETGSITVFDSSFTNTPVAISTRWTTTSTPDTAGTLVLENIALTNVPIAVKGPQGTYLSGSTGSTTITAWGNGHKYTPSGPVEFAGAVTPNPRPASLLASNGRYYTRSKPQYETLSASQFISVRASGAKGDAATDDTAAVQNAINTAVAQGKVLYLDYGLYRVTSTILIPPGAKIVGESYATILSADSFFNDMNNPKPVLQVGSYSGQAGTVELSDFIVSTQNAQAGAVLIEWNLASPASSPSGMWDVHTRIGGFVGSQQQVGQCLKTPGNPTVRQGCIVAFMAMHVTKGASGLYMENVWLWTADHDIDDAANTQITLYSGRGLYIESTTGTFWLYGTGSEHHVLYQYQLSSTQNIFMGMIQTETPYFQPTPNALVPFPAVSSLNDPNFSSSCAGVSGNCAAAWGLRVLNSKNILVYGAGLYSFFSDYSTTCSTFAAGQTCQSRIASIEGSASNVNIYGLNTIGAQSMLTRNGVSVAWYADNVNNFPSTVGVYKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ95</accession>
    <name>A0AAE0MQ95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_476739</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678890.1">
        <property type="nucleotide sequence ID" value="XM_062827389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87864543"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000090">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1231"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1265"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1117"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="738"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="709"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="862"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="942"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="943"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="944"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1040"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1046"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1091"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1094"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1095"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1095"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3339530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1295" mass="145822" checksum="7321D03725007F54" modified="2024-05-29" version="1">MRSLTRSTAEEGGASVDSASLEKGINTFSKAGILAPLRKTGTSATTVTRTIKASTQQLYRKYVLELIFQEKELPPSKDGRHVPLRPHHDKPLIDERRGSAYIPNTIRTSRYTVYDFLPKQLFFQFSRLANFYFLCVGVPQTIPGVSTTGNFTTIIPLLFFIFLTVVKEGYDDWKRHRLDKVENARSATVLRPTGHVDSRQDWRTGFGLRKAKEKDTLAVEEVIPDSEYQWHATQWKDLKVGDVIKLSRDEDVPADIVLLYADGENGMAYIETMALDGETNLKNKQVSKALQRCNTIQGIANCQAELVVEDPNPDLYRFDGRVTVDGETLPLTLNEVVYRGCTLRNTRCAIGLVINTGEECKLRRNANRHPKAKKPAMEKISNKIVISLVVVVIALSVGCSMGYLIWRDAYEHKAWYLKHLGVEFEDIIIGFFIQFNNIIPLALYVSLEIVKLGQMWMLNSDLEMYDKVSDTPAKCNTNTILENLGQIGYVFSDKTGTLTENVMKFRKMSIAGTTWLHEMDILKEQEEQGLTQTKTKEKETKIMMEPTPEYDNALTKTTTVVSVRSPNPRRSSSQWRSTGQPDHVQPEVTTEDLLEYIRLRPNAPFSRRAVQYILAIALCHTCLPEIRDGEIEFQAASPDELALVKAAQELGFLVVQRSSQTVTLRISRGDGREVERTYQILDVIEFSSKRKRMSIIVRCPDERIWLITKGADSVILPRLRMAQLAIQKANEVRKSLEVEHEMQRRSEAREPRNSFGGRPSLTIRRSINLARQNSIAGPSKRPITNRSKSFEVGRMSLSAPEDRLRPHITVRTASHDVPYEDAVLASVPDRFAFLDDPSVCDEGAIFTRCFKHIDDFATEGLRTLLFAGRFLSESEYKTWKKLYHDAETSLVDRQERIEAAGEVVEQTLDLIGATAIEDKLQKGVPETIERLRRANIKIWMLTGDKRETAINIAHSARLCRPTSDIYILDAVKGNLEGQIMDIVDEMNIRAETMPTAIPNHTVVVIDGHTLAALDEPGAHGNAKELFYSLIPTIDSVICCRASPAQKALLVTAIRNHSHQPVSMTTTTKKKSFFSYLATPKRTPPLTLAIGDGANDLAMLSAAHVGVGISGREGLQAARVADYAVAQFRFLSRLLLVHGRLNYARTAKFIVATFWKEMFFYLPTELYQRYTGYTGTSLYESWSLTVLNVLFTSLCVIVPGVWEQDLSPETLMAVPELYVWGQRDGGLNLRKYLGWMVAAVAQGVVVWWVCWGLYGGIAVKDNGLFAVGNLVFTVAIVWINLKLLYVLSPPSFHTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQA0</accession>
    <name>A0AAE0MQA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_445710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678905.1">
        <property type="nucleotide sequence ID" value="XM_062825763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQA0"/>
    <dbReference type="GeneID" id="87862917"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="206" mass="21983" checksum="2FB2E0DFB153A305" modified="2024-05-29" version="1">MASTKRIAKEFADCTTAPPPGISITLPSDADLHTWHVTVTAPPNSVYAPGRFGLILKFPVDYPFKPPTINFTTRIYHPNITNDSLGNICIGLLKSENWKPASKVINVLEAVRNILVEPMPDDALEQRIADEYRRDRPEFEKNARAYVERYAKGTVNFVQAPPPPEQKDGGAPAAGGATGAANPGRAAGRQGGGSGLGSASRPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQT3</accession>
    <name>A0AAE0MQT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_526850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680526.1">
        <property type="nucleotide sequence ID" value="XM_062828864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQT3"/>
    <dbReference type="GeneID" id="87866018"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="296"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3342733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="467" mass="51162" checksum="05C15972C912B58D" modified="2024-05-29" version="1">MPVTNFDFKEKYRYQNGFASYLESEAVSGALPIGHNSPQKPPLGLYAEKLSGTAFTAPRHENKQSWLYRILPSCSHPPFVEATPSKGQEPVLEQSPAKLHYIPNQLRWDPFDHESDTDFVSGLRLVAGAGDPTLKQGLGMYVYAAGKSMSAQSAFYSADGDLLIVAQDGVLDIRTEFGWLLVRPMEIAVIPRGVRYQVLLPSGPVRGYALELYQGHFQLPELGPIGSNGLANARDFQAPVACFSEDHGSIALDGPNSYTITAKFNNTLFETKQPHTPFDVVAWHGNYYPYKYDLGRFNTIGSISFDHPDPSIFTVLSAPSDHAGTAIADFVIFPPRWLVGEDTFRPPWYHRNTMSEFMGLITGAYDAKKGGKGGFVPGGASLHNVMSGHGPDAASYEGARNAELKPQKVGEGSCAFMFESCLMVGVTDWGLKTCQKVQEDYNEHSWGGVKVHWKGMAGGEEGVSHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRL6</accession>
    <name>A0AAE0MRL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_241866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680959.1">
        <property type="nucleotide sequence ID" value="XM_062822335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRL6"/>
    <dbReference type="GeneID" id="87859489"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3343166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="232" mass="25749" checksum="DB038E388BE5C30A" modified="2024-05-29" version="1">MSAAAAPKKGYLVVFALPTHPSFSSSHEIFNKWYNEIHIPDMLSYGRSSGFVTAIRYARAGFSPSNPQVSSTANDVTYPKDVKWQYLALYPVEDVEKARAPESGLYKVPLEHEMLPGRNLMEVAKWELDFWEVVGETGGDSSKQTDVILVPVDSSDVPGADPSAILDYTRKGWEGPDPVRSTLLKFIAPAFGGDATGIKQYLAVHEVEPNTEETLKPELKTVKYKFFKKFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSG6</accession>
    <name>A0AAE0MSG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_201189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681874.1">
        <property type="nucleotide sequence ID" value="XM_062821788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSG6"/>
    <dbReference type="GeneID" id="87858942"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="23023" checksum="A45A0388510A12AD" modified="2024-05-29" version="1">MASCPAEVMAVTPVTPTTASSSGAGDDGRQRDAAKHSQFRNRKLSPGSLHGSPCLSSSWPLSSRAQALPAEKASQVAPKLNITVITHSEHSLTQARKIALHVPPCVLAYQGDGRALAADLFLPFWCRAAVGPVDPAWTLFFRKLAEKRTSKRRWCNKCSDKRYRLLFIAVSVPAGNGIWTKSLQASASLLPGKQVCVDCGLSREYGIPSAAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSR6</accession>
    <name>A0AAE0MSR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_148721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682521.1">
        <property type="nucleotide sequence ID" value="XM_062821049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSR6"/>
    <dbReference type="GeneID" id="87858203"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="226" mass="24182" checksum="AF85C10D0FE2F7F0" modified="2024-05-29" version="1">MTTLLVPALRTTHFGSSAGPGEEMLIQYDSHGHHQSLPLPSLISKSFDSSGSFHKLFAHLPCISPRSFGKPKGVGTCELVDFGKQIGRAPWRPRPPFADLADQPWAKPMNCLLADWSLAFRSQHPALPSPLAPAETPFLPFLRRPISVAGVHFLRVAACFGFFSSCCVYNVGGCGGVRIPSSLPFAVGKVPGSGGDGGPSKGHGCQILGWHSGQMWTRCQSPSHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTA0</accession>
    <name>A0AAE0MTA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_205216</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682025.1">
        <property type="nucleotide sequence ID" value="XM_062821861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTA0"/>
    <dbReference type="GeneID" id="87859015"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="200"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="416"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3345412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="521" mass="58710" checksum="9D762B9BD1C00B0B" modified="2024-05-29" version="1">MAGPRVLAANVMRVVPRIGARSHVRASATASLLRLSAQAGGRLSLTRAPSHCLRVASYSSSAGGAASSPPPPSTPNSSRPATIEVNGKTYTTDEWYNVPQTVLALTGRKLHLQKDHPVAITRQIIESKFPTATYKRYNEFDPVVSTIQNFDSLGFPPDHVGRARSDTYYINETTLLRTHTSAHQADTFRASASDGYLISADVYRRDEVDRSHYPVFHQMEGARVWDRTKVPNGDVVAAIYADLAKLPTHDVKVEDPNPPHHPERNPLQSEHHTPEEAEAVAAHLKRSLELMVVEIFTRAKQAAARQDPNYVDEPLRVRWVEAYFPFTSPSWELEVYYQGDWLEVLGCGVCKQELFINADQPQQLGWAFGIGLERIAMLLFQIPDIRLFWSKDERFLSQFTGVQDGLDKLKRFVPFSKYPACWKDVSFWLRSTSAAGGNTAVANVHDFHENDLMEVVRDVAGDVVEDVQLKDQFTHPKTGRKSMCYRINYRSLEKTLTNEEANDFHERVRQGLVEKLGVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTR1</accession>
    <name>A0AAE0MTR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_586158</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684093.1">
        <property type="nucleotide sequence ID" value="XM_062830944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTR1"/>
    <dbReference type="GeneID" id="87868098"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="81"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="274"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3350798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="423" mass="46858" checksum="6A015133DF129EAC" modified="2024-05-29" version="1">MAARNCTKALRPLARQLATPAVQRRTFVAAANAVRASVAVKAVAAPARQQVRGVKTMDFAGHKEEVHERGDWPAEKLLLSYELSPTMDHPKVWAGHGGGDYFKNDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKNGKSWEDAIQDGWVPGKNLFDVDEAISRGTIVMNLLSDAAQSETWPHIKPQITKGKTLYFSHGFSPVFKDLTKVEVPTDVDVILVAPKGSGRTVRSLFREGRGINSSFAVYQDVTGKAKEKAVALGVAVGSGYLYETTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGAHGMDWMFDACSTTARRGAIDWTPKFKDALKPVFNNLYDSVKNGDETKRSLEYNSQPDYRERYEAELDEIRNLEIWRAGKAVRSLRPENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV16</accession>
    <name>A0AAE0MV16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_125691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684861.1">
        <property type="nucleotide sequence ID" value="XM_062820735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV16"/>
    <dbReference type="GeneID" id="87857889"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041768841" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="577" mass="63650" checksum="74E096CB75E1BDC1" modified="2024-05-29" version="1">MRLIALVSSLLLATTATAGGPSFGKAEKKYLEHVANRLKNHAAKVEAAPVVERDVAKVQEPKFLNDNTTKFAVDGKNIPDVDFDVGESYAGMLPISQDPEEKSELFWWFFPSTNPAAKKEILIWLNGGPGCSSLEGFLQENGPFLWQYGTYKPVKNPWSWHTLTNVIWVEQPVGTGFSTGNVTATSEEDVAAQFMGFWKNFIDTFAMQGYKVYITGESYAGLYCPYIASAFLDANDKTYYDLSGLMIYDPVISWDEIQEPIPVVQFTEYWSGLFPFNDTFRAHIKSVDAKCGYSDFVSQYLVYPPKGPQPSKLPGTDKNGTTRNECWGLFYDVFDAILLLNPCFDIYQVATTCPLLWDVLGFPGSMGYLPEGASVYFDRDDVKKAIHAPENVKWSSCSEQDVFVGGRDQSEPSIFHALPHVIDATKNVIIGHGAMDMVLIANGTLLGIQNMTWGGKLGLQNKPDQPFYVPYNTISDLSTLAAGGVFGSMGSERGLTWVQIDMSGHMVPQYAPSAAYRQLEFLLGRVNCLNCTVPFTTNPDAPQSQQPLGKGTAPQSWSKFSGKKGGHHGGGKGRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVC1</accession>
    <name>A0AAE0MVC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B0H65DRAFT_418798</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685176.1">
        <property type="nucleotide sequence ID" value="XM_062824164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVC1"/>
    <dbReference type="GeneID" id="87861318"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042091212" description="chitinase" evidence="21">
        <location>
            <begin position="18"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="23">
        <location>
            <begin position="23"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="22">
        <location>
            <begin position="355"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="412"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="496"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="830"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="900"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="518"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="936"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK3351881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1014" mass="100569" checksum="769D7DA3084D0412" modified="2024-05-29" version="1">MHKSLVAAAVLAATARAATVSEPKVNVYWGQAGNTRLRDHCDQANFDYVTIGFVNNSPEQDKSGLNYPGTNFGSHCDATYYTNSKTNVASPLLSKCTVIAADIQYCQEKGKKVLLSVGGASATGSNYSLSSDVKGQEFASFLWGAFGPYDSKWTGPRPFDYAGNHVSVDGFDLDIEVKFNTVGQNAYVALAKKLRELYNGNSKYLLTAAPECPLDVANFKMKSIIANAQFDALFIQFYNNPGCAAASTAGFNYLAWEAAIATGKSKNAKLFIGLPGSSDAAGSGYVEPVKAAALINTYKTRASFGGAMIWDVYYGQEVTNGKTFVDAINTACHGTANPTTTTTAAPAPTAIGCTAYHTVTPGEFCYLIAQNYGITVTELIRYNPALDAACAIQVGQKLCVKQGIVTLTSTSASATTTTSTSSSSSVESTTSTSTEAPSSTETSTSTEAPSSTEAVSSTITSAPATVTSSATVSESASVIVSESASSTITSAPVVISSSAVSSEVPTSTDEDSCDDETTTSSEIVSSTEAPVSASATESASATESASATESASATESASATESASVTESASVTESSLISVSFSTEVPSATEGPSDGSSTTVDPSIITSAPVDVVIPSGSGSSEIISSTTTEDDSCDDETTTEAPVGSATESAVVSSTEAPIVSTTESAVPSNIVSESIIPSGVVPSGVVSSIISDVTAGPTDGNSVVVPSASVSVPAEGGISSAPGAGVTSAPAEEWTTSTIYTTTTSTITSCAPETSASAPTGIITSVPIESIPAGFTTSTIYTTTTSTITSCAPTVTDCPGKIGQVTTIVVPVGVTVCPITEAFPPATSVPAAPSAGAPGAPGAPAVSAPAVPSGGAGVPAVSAPAVPSGGAGVPAVDTTSTTSVTSVHFTTVTVAKPTASAPGAPGAPGAPGAGVPAFPSEVPSGGNPVPPVVNAPAVPSGTAPAGTAPAGTGVSLAPSSAPSTYSMPAPPAQTEPATGGSEPSEVPVTAGAGRNVVAIGVPALMAALVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVD9</accession>
    <name>A0AAE0MVD9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_555866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684215.1">
        <property type="nucleotide sequence ID" value="XM_062830038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVD9"/>
    <dbReference type="GeneID" id="87867192"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="488" mass="54058" checksum="2B4DE6F8B30A6B25" modified="2024-05-29" version="1">MILAPAGRTGTATCRDESTKEWLETPPRRWSAGEWRRFLSASLIRLTAHHHPSGTSAHCYRTPSDVDTVIQAEPSLRAHMTQATQAKVMASFNKQYFSIHSTYLSSQHSTKMMPLLVNNNNNNFNMDLPYQAPVFSTNMMETPFDKASQQYIAAHTRNMSRGYGGQRTNTSMRITKPSSASTSPRYSFSQSRRRTLIGDGFQNLYTQPAEAAYLPTPAAEFPVEFMYEPERKPTTTARPVSWHPSSQQVAYSQPYPQESTMAYAPYPSNQDFGACTQFQQLPPTPSVYSGSNSPCSASFSPLSLPYASVDFQQSQHQYASAGTQLYQPAPESPQSLAGMTGDLSYAAFSKAEGNVMGWTSYAPVSSGLDTYTAPPTPKNFELLEQFTNTKVASEEPVSYEAPEDDESDGEILYGMGLYDPPETNEPAGMDLHRSTVFSLLGNAGAYEKLSGKGLKLEDAWEPPASDDEEDDEEEEEDDEEEERQDGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVM7</accession>
    <name>A0AAE0MVM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_20053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686042.1">
        <property type="nucleotide sequence ID" value="XM_062821780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVM7"/>
    <dbReference type="SMR" id="A0AAE0MVM7"/>
    <dbReference type="GeneID" id="87858934"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="118" mass="14071" checksum="16CB718E6D08F018" modified="2024-05-29" version="1">MTPEEMGIDTSRRNPSPRPLSDNERARLEEFIDSIHYSTRYSDSEYEYRHVQLPKAMLKAIPSDYHDKSKGTLKLLWEEEWRAMGITQSLGWEHYEVHEPEPHILLFKRPLNYQPPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVQ6</accession>
    <name>A0AAE0MVQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol N-acetylglucosaminyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_23328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686132.1">
        <property type="nucleotide sequence ID" value="XM_062822219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVQ6"/>
    <dbReference type="GeneID" id="87859373"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="684" mass="72639" checksum="4A5D610167BE3FC0" modified="2024-05-29" version="1">MAPPSGLHQAALSSDFETPFPPLVRSSTVPVGPKSHRTDPSHLAPEDAYSPVSPPRRTGLYNVDGSGSGSNAPNGSTNELRPRHIRRKDGSRSRSRRRQKRFQKLLWVKQSYPDNYTDQATFLEKLQRNPRVKPYDFWPLVADSTVIVQQVCSVIIFVVCFVGIFQERVSPVSVVGFGSFATFIGWLLWDWWVGEESLRAQGAMDGTTHSYRGRDPRPVRRQDSLGGPTRNASIVSLSGAEAGAGAGAATSTPASALPSAAPSPRPDQQLHIPRFSIGPTDSRSASIEPSTAAASRAGSRAQSVADFHEAHYGHHRHRSSTSSPIRGGGVIPGNSRLQLRLSTIKSAILIYFTLLGLSPILKSLTRSTSSDSIWAISFWLLAINIFFFDYSINNNPFTQATITNPHSNQTGGIVTGGSTPAPAGVAVRAVTGAGAATGTATPIPTLTSTSPTASGTSTPATGTRAVPGTSTTPTATGAPSATAISTATGGTAPIPTQHKFPIASLSTNAALMASTVLASRLPSTGQVFSLTLFSIEVFGLFPVFRRYARHRSFRYHLILTVLLLLGAGAGVGIIIGAPCPPPGTSSLSGIPTGAADIMLREDGIGMKGMEGMILLGGMGGISQCWQTWLKHSLLGMIVSCLIAALAMGGCSWWLIGLQKYKNEIYGPWDPARPIIISRRYYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVZ1</accession>
    <name>A0AAE0MVZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_13468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685836.1">
        <property type="nucleotide sequence ID" value="XM_062820849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVZ1"/>
    <dbReference type="GeneID" id="87858003"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF2">
        <property type="entry name" value="SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="6">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="463"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="56942" checksum="86EB0AB12F34CDD1" modified="2024-05-29" version="1">MQSVQRQFTKLRSKGPGNNAAVSVLLKEYEDADQLLARLLENSRAWRDAWASLIHHQLQFVVELEGLYDPIVGASDGHGRESVPTPRLQLERTFRLKQAYGELKSELAEEIGTIEERVVRPAVEARDCIAPIRKTIKKRENKRLDYERAQDKVSKLHKKHTRTPKEEASLAKAEAEMAQAGDEFAIADEHLQSTLPPIINASFSLVPCLQAALVLIQNRLLGLYYTTVHGYCMESGFPSPPPPMSEVVAAWEAAFVPARDDFESVSIVARGKAAHSPMALQAPEGPGRRISAMIPGRNDMRRVTSPMPSTSSASTYGGGGGHPGRNNLRIPSAGGYPSRTPSPAASDRSSYASSPPASSYSGYSGSQSQPRRLEYLAPTDFTTATSLSDRGPVDRTTLENNRPFPRSPSTPSMSINRAHSPQAIRSAGNSNGNGNGNDYFALAVAKKRPPPPPPPKKIASQQQLVEYVVAQYAFAGQGAGDLAFNEGDRIMIVKKTNTDQDWWVGELNGKRGNFPANYCKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW32</accession>
    <name>A0AAE0MW32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_36104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686477.1">
        <property type="nucleotide sequence ID" value="XM_062823676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW32"/>
    <dbReference type="GeneID" id="87860830"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="306" mass="35317" checksum="37D58DF9B442556A" modified="2024-05-29" version="1">MKQPPIEDLIYGYMFPKARPSDPPNFAVFLSRHLIYEVRQEVHSYYGHIDTQEAKYPGLDYNHPIHRIRLSRWQWHRRLFRAFDALRLTEWEIANLTKWEGTRWAKEKYEEEQGIVIRDTAADGFPDLTYPRDRVRIEPEFGSELHVEAAPEAVEEDEDEVMNEDEDEAMSDEDEIYSALTVPAAFGYQSVVSNNILAAPLDEEWLKNAIETGQLPRHSDTTNSELSAPRILAAAREGRWHEVPTIYRDVLQSRMGTHFGPLFGNSQLRTRHFQYGTTAGQTRRTTSELRLATATNSSQRVARPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX62</accession>
    <name>A0AAE0MX62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_72519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687631.1">
        <property type="nucleotide sequence ID" value="XM_062831332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX62"/>
    <dbReference type="GeneID" id="87868486"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3356254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="692" mass="77644" checksum="866E210713487653" modified="2024-05-29" version="1">MNPYPPRYDDNWVLKELNRASDERSTTATESAHEDNPFEDPSIAPSAFSEVSSYFLDRDTEIRKLLRSDAPLNSVLPGPHPADIAGMVDGYLNPEQYPTSADLDNDVSMGDAQDAADNVDNHCPSTWPSSEIPFRPSTSGSNGLLAPPSSHTRRSGGRNRNATLNWNPGTEPGHRTPAVVPEQDYFLVPSIAPSTVNQSFASGFNEDAQMTVAPAIPIINEPLPFTLPETQNILDLDPQPHMSANLDDDLLSLDTQSVNGHELISDVSSNASVRSRKLKDREKTKRVRKKGACSACRIQRIVCDSGDECEHCRDFCTENHCPFVPCIRKKLSEILGGASERWASKDMCGWYESLPKGPTRPGSSDHVVEIRRSPNFNRESLEVTCREVMFQSSEPVSCYPIYLPITDKSPSNETICAWSERDILLEHRTTFGGRIEQCLVSYKRVFHKTYVSNGRLSSPAQKEAVQLHRLMENVCNMTCMVKIWAYEVRNMFFTGGMPFSQQLLPVQLHFHLRAGKAISSTERELLGGLDAFLGPPTTLKQETSGTRSAFTVALWLSMWQVILVYQEVLGQLSSADVMTESAERRSFKRLTEDLFEGVVVMYSNRFRTSAIVKRVLDAMDDLEVFGNSDVALSAFKDAWNSRNDFYNEIERNPLPNRQVTLLRTCVIAREEAIFNKRNGIDAIQRQKYGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX84</accession>
    <name>A0AAE0MX84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S12, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_452800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687081.1">
        <property type="nucleotide sequence ID" value="XM_062826118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX84"/>
    <dbReference type="SMR" id="A0AAE0MX84"/>
    <dbReference type="GeneID" id="87863272"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3355703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="152" mass="17382" checksum="4D4A4F2A73EF8E68" modified="2024-05-29" version="1">MADEYNAEEAAELKKKRTFRKFSYRGIDLDALLDLGSDELRDVVHARARRRINRGLKRKPMGLIKKLRKAKQEAKPNEKPDLVKTHLRDMIVVPEMIGSVIGIYSGKEFNQVEIKPEMVGHYLAEFSISYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXJ9</accession>
    <name>A0AAE0MXJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_65224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687378.1">
        <property type="nucleotide sequence ID" value="XM_062831228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXJ9"/>
    <dbReference type="GeneID" id="87868382"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF4">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="708"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3356001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="951" mass="104322" checksum="039F12858AA7513E" modified="2024-05-29" version="1">MPPGRPPKRPSEAGDAPLDNGSQPKMKLPRLERSTEDFSSVVKTKLSQYTRTGQACDRCKVRKIRCDASPAGCSHCASQNIECVVTDRVTGRTERRGYTQQLEAENSTLKNHIKNLERVLADNGVEVRPWEGSNANRNPYPPGITLDAMGNPIHDPMSQGEWQQQGSVWVRKSRQGSQSTPGRYTRCSLLESRPTESYLGVTLDSEPLSSIKGTTLSVLGTTIDITSFDAPDMDEPSPTTPIGSPLYNKSVMAFYQSMVRINPPMEHCDLPSRHDAFTYAEWYFLTIYPFMPLVHRPSFMQLLTRIYDEPGFKATVPEMVIVHCLFATIYFQFFIRNREKPEDHAQLNNLSNKHYHWCLSKFFELAVSQTVTAVQALAMLASHTRNFPKPGCSFTIANFAMMKAIELNFHRSNKIPNGGTTLENELRKRVWWSILGIIITLNGRLGRPMPITLEEFDIEFPIAINDEYLGEDGVLDPSKIGHCCYQIGLAGFKAVPLFMEMYSSIYSVRRDPKKYVDVVRELSQAMAKLMNDLPDCLRVEKCQPTDLVFALYTQAISLEFNLCLRHPSVCLEKDPKFCAENTRICEQTARKLLKVVGELLKLKSLDTTWYQLSVYVASMLSILVANWERRHEITHMEIATLRADMALGLEIIAEIGRLVGTGNRLATEISSIYERTIAWIERDMTRKDGLSVDQTIIKQQSASPFQQPLLPFKQPLNSNGMTSSNSVTPNDHRSSVSTNGTGYYDGSATPYQTMSLNDNGANNGVNLAAYDPSGGSAQYLYATATPTSSTATPQTVTAAMDQTSAGTNPLIAFASQATQHVSATGQPGTGAEDWRPQVHPQFATAAVTSSVPNNNPWHDWAAAMADSQERYSASALLTLGSTRPGDVSGAGMVDHSHAHVNGGAGHGPGAGGPEALGVAVSAAAASAVVGGGGGQWPLLLFSDVIGNGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXP2</accession>
    <name>A0AAE0MXP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_584988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686675.1">
        <property type="nucleotide sequence ID" value="XM_062830914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXP2"/>
    <dbReference type="GeneID" id="87868068"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="250"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="490" mass="56964" checksum="A0C8D10A858ACD0B" modified="2024-05-29" version="1">MSDDDFMQDSDEEYDFEYEDDEEEDNGDVDIENKYYNAKQTKTSDPEEALQEFLSIPPLEQEKGDWGFKALKQAIKLEFKLKRYQEATEHYEELLTYVKSAVTRNYSEKSIDNMLNYIEKGYDDPKAVQCIEKFYSLTLQCFQSTNNERLWLKTNIKLARLLLDRKDYYAVARKLRELHNACRKPDGTDDPSKGTYSLEIYALEIQMYSETRNNNQLKVLYQKALKVRSAVPHPKIQGVIRECGGKMHMSEENWKEAQSDFFEAFRNYDEAGDLRRIQVLKYLLLTTMLMKSDINPFDSQEMKPYRNDPRISAMTELVDAYQRDDIYRYEDVLQKNTDLLADPFIAENIDEVTRNMRTKGVVKLIAPYTRMRVGWLAERLRITEPEVMDILSFLIVDGRVKGRIDEHKGVLELESREDADHIQGITVLSEAVGNLFNAVFKTTDGFQSSQGDFMNSMADQIADIGSLDDTMRSVGSGKRGRRMGLTQRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXZ7</accession>
    <name>A0AAE0MXZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_438840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686990.1">
        <property type="nucleotide sequence ID" value="XM_062825389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXZ7"/>
    <dbReference type="GeneID" id="87862543"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="410" mass="45420" checksum="4A836D7DFD05E9B7" modified="2024-05-29" version="1">MGSHLSTCAPKGGESYHCDYSIVGFRDNTSTIADGIPGFTSVALQNELQYLEPNSDVAGVGTLVGFVISFAASTLLSLFIHSLECHEIFGQGHKGDHEKHSAKQWWHIADTILISWSDQQLVLGMATSIAALKTWCSFSTYHLNLIGQWLVLCSVTHANALLVHCKYFHRKRLLADGLRVLTILTNLILSGMVFFVSRSVGGKGMPSVADHTPLQILPAQCFFKHAILAEGLKLVDGYNQYSHPNGQALFLMSLLILIAAGLSMAAHRWRGKGARKSRWSWGLRTVMLLANIGVGFASLVSSVGLRAWMHVEGWMEDDSELEWSYGQFIPALLGLLVFVSVLENVFDELPDRKSMDQQSLLQLGRDGQFEMDMRRLSAQSKIDFKSSQIPQTTVSPLDPRPFDPSEGRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J011</accession>
    <name>A0AAE0J011_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_480864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676628.1">
        <property type="nucleotide sequence ID" value="XM_062827605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J011"/>
    <dbReference type="GeneID" id="87864759"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="104" mass="11407" checksum="8DB782947B57CCD9" modified="2024-05-29" version="1">MCHWYIEYRFCSQGPHCLGNYGWANASSQLYVRPYASIRRNHPCEQSSRRGGCGQSTRLGPGSDIKTSDHMCGFCRGDVPKTDAGKKNDGDGGKGDGDKMDVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0C5</accession>
    <name>A0AAE0J0C5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_481118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676735.1">
        <property type="nucleotide sequence ID" value="XM_062827620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0C5"/>
    <dbReference type="GeneID" id="87864774"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="86" mass="8808" checksum="B5B96E0717D84819" modified="2024-05-29" version="1">MDTIKKKINKGLDKATGVNNEPQVLNKSSQSHALNITGIKDHQSSPLTSGLEKPQDPSKGLGAVGTGMTATGVSTGTNPNPAAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0Q3</accession>
    <name>A0AAE0J0Q3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Attractin/MKLN-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_81958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676571.1">
        <property type="nucleotide sequence ID" value="XM_062831457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0Q3"/>
    <dbReference type="GeneID" id="87868611"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041976805" description="Attractin/MKLN-like beta-propeller domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="7">
        <location>
            <begin position="115"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3334405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="709" mass="74684" checksum="F91F4087BCD9626A" modified="2024-05-29" version="1">MVGFNGTSTCRTLLLLLGFLIKLSVAQFDPIKDFCRRFGHQSAVVDDKLYVDGGLVNWKPYSQTSANISNQFLLYSDLNHETDGMPNVYANLSKNATIPSVSFGILWEDSINKWLYSYGGESQSTASNFILYGYDILNNYWTSFGPPSSSGTITPLSHGAGVSISERGEAFYYGGWFSENSVPGWSGTRRASDRLIKYDMDKHEFSNLTGPDNVRRAEGTMVYLPISDGGMLAYFGGVRDNGNGTVSPQPLDTIFMYDLANTKWYTQKTSGRAPEDRRLFCGGAAVAQDQSSYNIYIYGGASFGSNPIGYDDIYVLSIPSFQWIRSLYPSNSNVTGEFPKAMASCNVINNAQMLVIGGRAMNDTTGCDADGVLGQHNMVLGKDNPEKAIWARFQPNLTTYTLPTDIVTVVGGNPTGGATVTAPPKTGFDAPDMSTLMTRKPRLAERTATRNVTTPTSSPTSDPSPNPHKKGLSTGAIAGIAVGAAVAGIAALASLCFFCIRRRQKHYKQPRVGGAPVTGSNPASPMAQHPPGSSGWADGPGGATISSPTFSQAPTYNTQATELPPSSPPSANGHGHGYRGVALAPPVELPGAEAGEGHIAEGKTKYPGSGTVSGSQEMPVTPAKSVGTGYHDNGHGHARSPSDLGPGDDAISRGGLSPSLPSPGNGTGDSGRFGGNGGLPPYSASGAYGGGPGGGRFEEDFGHGGTYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0R4</accession>
    <name>A0AAE0J0R4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_332065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676945.1">
        <property type="nucleotide sequence ID" value="XM_062823518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0R4"/>
    <dbReference type="GeneID" id="87860672"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000017">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000340">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="709" mass="76228" checksum="6DDE260A74C6A148" modified="2024-05-29" version="1">MKMYQHARHCSPVHSLQSQWACRLQTPSSSRRSFATCQPLHGSYADTLSFLRINSNTRVIFQGFTGKQATANAKDSLAWGTKIVGGVTPGRTGEHLGLPVLPSVRQAMEQLKPDATAIYVAAHQAPGAIEEAIEAEVPLIVAVAEHIPVHDMLRIHSILKTQSKSRLVGPNSPGIISAVGKCRIGFQPLPCFSPGRVGIVAKSGTLSYETVASTTRAGLGQSLCIGVGGDMVPGTDMVEALSVLEKDPDTEAIALIGEIGGMGELEAAAWIKEYYSRSESPKPIVGLIAGVNEAPGRIMGHAGAFTSLREPTAKAKITALEDAGVTLVNHPAKIGDILKTKLQGTAGSGTTSGSNPFASGTQRRQLHSMRGPERRPLVTGSSVHNKHQHQQRRSIYLDVNPCFAELRVRGGINCGPYSGHGTRRLLAVGIDRSARSPSILVAPSIEDWMEEAQRTTAPVKSFPFDYRRGPDDLAIERIASHLQLSNKGDSAVDSLPRLIKTLTRLFYEQEGLLLTTHIVERLGEIKVVHARFAFDQATFRNGTPQDKIKAMYVRATNEPAAIEAQRSGIVYVKLPGEDATIGTLVNGAGLAMNTVDALADVGGKAANFLDTGGKATSETVKESFRIILQDPRVRVVFVNIFGGLTLGDMIARGIIMAFRELSLTVPVVVRIRGTNEKEGQKIIADSQLPLYAFDDFEEAAAKAIELSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0V7</accession>
    <name>A0AAE0J0V7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_335826</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677049.1">
        <property type="nucleotide sequence ID" value="XM_062823568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0V7"/>
    <dbReference type="GeneID" id="87860722"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3334883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="544" mass="61557" checksum="7C702E50FF1253D9" modified="2024-05-29" version="1">MPPALRPAAPSRSLLRYLRAQSEGLSFAPTCRAAAERHPALQRRHVCTAGGPTRPPRQPSSTRSLSTATPPKRTELRAGLVDLEAILPKSLRKQRTTKSLLALPPPAGSLRFSSNQSSDCDPKRPRLREWLFGNGEKKGPPDTRLNDDDIRVAVEEESGSIFQRRTLMAKAAMDPRLRCTEVDENGNVVMVDGELKKSELIAKYGLLPRDLRKIDSSNLPHILIRPSAILLNLLHLKVLIKHDCVLLFDVYGSKSSYPQSAFMYDLQGKLQQKQSSGANSLPYEFRALEAVLMSVTSELEADFEAVRDPVIRILSELEDDIDREKLRVLLVLSKRVSTFEQKAKLVRDAIEELLEADDDLASMYLTEKTHDLYRGEEDHTEIELLLESYNKICDEVVEEASNLVSSIRNTEEIIRAILDANRNSLMLLDLKFSVGTLGLAMGTFLASWYGMNLENFIEETNWGFAMVTSVSTVASLIVCWYGLVKLRKVQRVKMGDLHNRNAPNHWFRDESTDVLLDPSNRERLRRINSMKSAQQKRFTNKKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J118</accession>
    <name>A0AAE0J118_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_565916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676736.1">
        <property type="nucleotide sequence ID" value="XM_062830304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J118"/>
    <dbReference type="GeneID" id="87867458"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="358"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
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        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="659"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="732" mass="78837" checksum="99F1C2F4293336DF" modified="2024-05-29" version="1">MNHADLQSEIHTKMDAPANKNMDGAAPRSTAVPGSSHSKPDTNSSKTPAISSSTRPLTITKITPNGATSNAAPYPTPVTTLRNNDPAVSSPLASAPILPADTKPMTGTSNTDLPARSNLPPAPPPNLLPGPQQPPHERTQHQQLLYSQQQEQLLQQLRQQQQCHERQVRQLRQLGLLPPLQRGQLQGPQPPPPPQPQPPHAHTQQQKQQQQTPAQQLREQQRQQLVQQLRQQQQHQMYELQQLGLLTPLQKEQLQDPQQQQPPHPHAQQPQQPQQQEHQEQPQQPQQPQQQEHQEQPQQQEQPQQQEQPQQQEQQEQQQKLHQMHQLQQLLVLLSQGKLKQPQHQQLLQELLQQLQPQQLHPPSASAPVPGVPAQPQKTQADQGSSSSPSSGSGSVPHIPSFPLHLIPGVHISLEDYDRYRLLVHNLHFQRVFRKDPVLALLLSDEFRIRLELQRLLPDNRPPKKFVSLREVQRKPLSEYEWEVEGRIQSGTKKRGEGMCRAQGQGQGQGQAGGSAHARASANGGGGGLYQPQAQAQAGGSVGGSGGGREMGATAADIWAKAAAAAAVAEAAAKAAGVSVGPRAGGWINGSNKKRKVSPGTEARPEKRPRTEVNTGMGTASAQQPKQEAGPVQKVGGVQKAGGSQSAGGSQSAGGLQNTGGVQKSGRSQNAGGLQNTGGVQKSGRSQNAGRPQKSGGPQKSGESQSAGGSLNAGGSQKIGGMSRSVEAGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J144</accession>
    <name>A0AAE0J144_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_583338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677159.1">
        <property type="nucleotide sequence ID" value="XM_062830876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J144"/>
    <dbReference type="GeneID" id="87868030"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041912012" evidence="1">
        <location>
            <begin position="33"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="270" mass="30029" checksum="CB6A2DD2F0C50B40" modified="2024-05-29" version="1">MHNNTSKKELSPLCTFLMRVLLLLSYTSAAHCLELLDATLWPAISQAQSSTAGQAVSVLRRKNIATPSTTALDTRTLHTRVQAFHSLPLRRTGVPSWRKLVEGLGSLGIRAAIRELCYVYYQLTRSTPHDIPSQRSTAMHDLIVQRVSELTRMLITPTFLMRVLWLLYTSAANFLELVDATLWPAWKAAVMCLDQHIFGTIIIIVAAVTGTPHFRQSRRSVPFPVVKKELKARVARRGSDVDSDVSTLSERETQAAVNTTVAGLLALMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6T2</accession>
    <name>A0AAE0J6T2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_309030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677423.1">
        <property type="nucleotide sequence ID" value="XM_062823263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6T2"/>
    <dbReference type="GeneID" id="87860417"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041766218" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3337972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="464" mass="49621" checksum="289C6C675B4C30F2" modified="2024-05-29" version="1">MRSTIIITALAASGAVNAGVTGTKNSKRATITPITTKGNTFFKGNERFYVRGIAYQPGGSSANLDPLADPKICLEDIKKFEDLGINVVRVYSTDNSKSHKECMEALADAGIYVALDVNNPLYSINRATPHPSYNAVYLQSVFATIDEFAQYDNTFAFFSGNEVIHDEAESTLAAPYVKATDRDMRAYIKARKYRAIPVGYSAADVSKNRMQTAKYFNCGTDEERSDFFAFNDYSWCKSDFKTSGWDVKVKNFTDYGLPIFLSEYGCTTNGRDFGEVSALMDPKLMTKVYSGGLMYEYTMEENGYGIVNITKGKDITDQTGKRIELPEFAAYKKALATYPAPTGDGGYSQTTKAQDCPPKDDDWLVEDNKLPEMPAAAKKFLENGAGKGPGLNGPGSQWAGDASPTTTGGSGSGSGSGSGSGSASSTASATQNAAGFAVSGPLNKGPFVVTGLAVLFTLVGAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6U9</accession>
    <name>A0AAE0J6U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_309143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677424.1">
        <property type="nucleotide sequence ID" value="XM_062823264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6U9"/>
    <dbReference type="GeneID" id="87860418"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="28"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3337973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="294" mass="33161" checksum="B26EE38C0903FE26" modified="2024-05-29" version="1">MLTTGGERPLVPMALLSAAKLAALIGIFCSVVAVEGRPDVHNHFDFPGSGQGAPVAQGVPDDVRDWRPYQRYYLHIHGIIAALAFVILFPLGSILIRLLPRRMALFAHATWQLFTLLVYMAAVGIGIHLIKLRPDMMRFGRMNYHPIIGIFVLALLFIQPLVGIFHHKEYKVNRRRGLWSALHLTIGRIAITVGIINGYLGLIAADDTRTKVKAIYVAVALALWILWTAMSMWWEWKRHRRERSEKELERALAEDRTGVGANRGINGIGNRRPVNDQSDTRAREALRKAKRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7R1</accession>
    <name>A0AAE0J7R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_592097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677563.1">
        <property type="nucleotide sequence ID" value="XM_062831120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7R1"/>
    <dbReference type="GeneID" id="87868274"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041968851" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9234" checksum="0EAF45917FDD0E3B" modified="2024-05-29" version="1">MRAWQGSLSLLSCWTLRSLLIFAALLNSKRKRSTCHSMCFKTVVDSMQVPLRFAALPAPRAHKWCKLPGRCWYTIANPVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7S6</accession>
    <name>A0AAE0J7S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_325594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677984.1">
        <property type="nucleotide sequence ID" value="XM_062823465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7S6"/>
    <dbReference type="GeneID" id="87860619"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="227"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3338533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="416" mass="44670" checksum="529BD590021343C0" modified="2024-05-29" version="1">MAPELSSNWKKLQEKLKAPPTKSAPISQEAAFKQATSKKSISSETLKRKAEERAEIERSNALSKKQKTQSQSQSQSQPPRKTLTPKSQSSKPTTNPDSKSKMGAANSQPITSDSPHTNLPSLHLWASEEGISSESLAEAYNLGLRSSSSHIPLLSTLPPAVPNAGLTLTLPGNQTPTPTSSSNGLPLPSDLPSDLTLPLSNGTTTTSATTADLALILRATKENTLGKYLAIDCEMVGTGPSGLVSVLARCSLVDFHGHQIYDSYVKPTAFVTDWRTHVSGISKRHMAFARSFASVQATVAALLKGRILVGHDVKHDLEVLGLEHPHRDVRDTAKYSGFKKYGHGPKPSLRVLAKEVLGVEIQTGQHSSVEDARVAMLLFRKEKHGFDMENSNRYEEGQGKKGGKGGSGGGKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7W1</accession>
    <name>A0AAE0J7W1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport protein Avl9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_324764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677950.1">
        <property type="nucleotide sequence ID" value="XM_062823454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7W1"/>
    <dbReference type="GeneID" id="87860608"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="896" mass="97621" checksum="BB87AC63A576895C" modified="2024-05-29" version="1">MSVPPTPTTERKPGFTPLVAVVDFHHARGPEVERWFGVPEDSDPAAEYDWGLLPFMALSDGAHAATEDFSYFTLLRPATASDPEATSLFGISCTRQMDASQLLNRPAEVTRSTVQKAVVIIADSPQYFGMLRERLSVVTKAWFAQREFTDVEILRRFQESLADEKARGTLLGEKEEDRDLYLGMSLRELVREFRWQTLVLLKCCLLQPKMLFFGSRCERLCMMQFSLISLIPGLLRNLQDSAGPELDNYEKKLQRPTSLRTSDRNSLLAYMGLPLQIFGKGSLFGPYTPLQQLDVLADFGTKSYIVGSTNSLLLQQKDRYSDILINLDEDSINITSPSLKSALALSTPDRRWIDFITQNVNDTWDDANPGMPKTMGYVGSEEFIRLQFEEYLLSLISSVKYHNHLAIHSQNPRMLLPHIEGDPSLDFNADFIEAWKRTENYRIWDGHTDSHLFDIVEPKHPCAGGLTIDDVQRRIAQQVQDLHLDERFAVGKEVLGRNLQAGKEKASTMFNKFYADMEALREQRRKAAEEAEKQRQAEAAATGGNGQHGSEKGGSGGSENGNGGNGQGGLAPAAAVSTVGSKAGAFVSSWTAWAGEKRKGWGRSAPTTPITETTPIPPTTGTGTTTSDTSSPQDREKEKEQEKKGWGWSKAIRNRTSVLLSGGGGSSEERETFMPQSPQRNGAYAALPLATGSPESTRTTRTGNSSNTGGGQSRAFRRRALSGESMLDAAGSEDGFSGSEFGTPERVRSRETVASIARKPVGSGGGSGSRPGTAGTVGSVNLMSVASPEVVRGAGTTTTAAATVTEDDGKDEKVENENKEEKEDTEDKGMEEVSLDDAPATATEQVKKEPAPVLAPITTTDETQRESSRSRSPSPSPLQPPAVIVAAEEAAKASEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J970</accession>
    <name>A0AAE0J970_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_285082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678296.1">
        <property type="nucleotide sequence ID" value="XM_062822935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J970"/>
    <dbReference type="GeneID" id="87860089"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="75"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3338936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="447" mass="51650" checksum="048A4C09979E3DDD" modified="2024-05-29" version="1">MVRLKERISASWGKIQAKVRTSSKDTIEAMTLPLRRYPTKRLSTSFYTKNIMVVTSTTVDYDEAPNYDEAPKEPRSPECVVCMEESPADQLIYFCPPSPSEEASDSNPSNAGHGYCDGCLVQGIRTATKDRYPFRCCGKIFDTKDYTGATLSSEEKQAYEDMIEEIKTPNPLYCSNPRCSSFIKPALIKSDLGHCPKCSASTCKHCRQPYHPRLVCKQDQDTLKVLALGKEQGWKLCPVCGYMVELVKGCHIIRCKCAWSFCYRCGASNQSSSDDRRHTWHTGCWRPSDYALAVDNRPPEEEQLRRRRHRLDILGRIHDGWRNLARVWELELERERLRQRERARELEIARKLERLVHAELNPHQPAAKNNSNNNNHNQQARAMPQQNAQPHQQPRQEPRNPPHNRERGNLWRRMMVSPTRPVSQQPQPNPRPNHTPEPRGQKRRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J998</accession>
    <name>A0AAE0J998_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_445538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678699.1">
        <property type="nucleotide sequence ID" value="XM_062825752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J998"/>
    <dbReference type="GeneID" id="87862906"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3339339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="605" mass="66055" checksum="10DE6C895942B1B7" modified="2024-05-29" version="1">MATHSGFPDSDPASTSTRGTMADSRGMSSATARLRDTLKTNGFTDNVTEAMGLLGPDDGHDAPRKDSWAALKDFEELPWWRKPAVWWLVVPYAMFTLAFGGSLVPKINLYDSLMAELCRSSRNLIITLICDRYFADRSAADPGFVFTPVIHGGNNPQCNIPDVQRLVASFTLCMSVLVGIISAFTAPKLGALSDRYGRTSMVAICSIGGVISEITVILAGKYPDTIHYSWILLGSFFDGLAGSFTAGSVLIHSYASDCTPPSKRGVAIGYLHACLFTGLAFGPLLAGYFVKWTGSLLSIFYVTLGCHIVFILFIYFVTPESLSRRRQLLAREKYAREQEALGEVPRWAAVVSKFIPFGKHFGHGVRSVHRANPFAPLKILFPSGPQHKRLRRNLITLALIDVSILGTAMSSGTILILYTEFVFGWGNLEASRFMSLVSMVRIFVLIGIFPVINYIFRTRPAARRRRESGDLPVDEKNVGADELDVWVLRSALISDVIGIGGYIFARTQEWFILSAVIAAFGGLGSASIQASMSKHVPTERVGQLLGAVGLLHALARVFFPIIFNGLYAATVSTFPQAFFVLLCSIFAAALVASFTVRPHGMFSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9L7</accession>
    <name>A0AAE0J9L7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_551920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678538.1">
        <property type="nucleotide sequence ID" value="XM_062829856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9L7"/>
    <dbReference type="GeneID" id="87867010"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="151" mass="16060" checksum="F5A03D5BE9E0EBF4" modified="2024-05-29" version="1">MSATDATAKTFFSSPKFAVVGASTNTEKFGYKVFKWYADRDLPATPINPQGAALTVNGQSYPAIKSLSELENPKETSVSIITGPAITLKTLQEAKELGVPAVWLQPGTFNDEVLAYANENFQTVVAGKGSWGGEGWCVLVDGERSLGGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9P2</accession>
    <name>A0AAE0J9P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_580333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678568.1">
        <property type="nucleotide sequence ID" value="XM_062830790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9P2"/>
    <dbReference type="GeneID" id="87867944"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="686" mass="75995" checksum="1F8EEF15B0D2613A" modified="2024-05-29" version="1">MVRAGRQKVRTGCYTCKIRKVKCDETKPSCLRCTKTGRRCDGYPAAPLHSQSWQELLAKRPIIPAVTHRHNSQEGRALEFYRCVLAPTFSGSLDDDFWTHVVSRASYQNPVVRHAVVAISSICELISDPSVKGQALVKFPKGRYAIGHYNRALQDISKTDDEAMVIFVCILFVCIEILQGNREAAISHCHHGVQILNQLNGGKSKLNSSSSILSRDQLLNPFARLSIFPFFYGSTVDVFPRLLRHGSEAPESDGGTYGAGTAAALASDSALTVLDELRSGLDLLVARAMRFLRSADLYRIGPSRHEPVPSQILTEQANLTKSIDDWLVRFTIFSAVHSPTEDAAGLFYQMRMKSYITKIWIATALDRTEMVYDRFVPLFREIVDMAGRYLAAEKSRPRGPSPPRQATEEDAGGGGGGGPASPPNNSNTNNTNKPRFVYEMAYLPMLYFVVMRCRHLETRVTALEHMTTLSALHQGLWDSTLTFCIGWRLIEIEHGADRETLLLSMAQAKGLGHQSISRRTTTTTTRLAPDVNSLVGRMMPGTTPMPPDRMRLRECVITGDHTVEQEEDNPGTGAGKGLRTGYRRVIFHVWKPEREGGVGTFEEWVPISEPPPMRDMCYDYEFGAAPAAAGAGNELVEVKLEHGYNASSLVEAKHSFGFVDLGGGEHDLPTRTMPPVYDGFKLESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9R2</accession>
    <name>A0AAE0J9R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_433512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678954.1">
        <property type="nucleotide sequence ID" value="XM_062825077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9R2"/>
    <dbReference type="GeneID" id="87862231"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="397" mass="43712" checksum="6CD2F9F678BCB9FD" modified="2024-05-29" version="1">MMERGNRHSSSGATAVSNESAMNSDLMSFTALEGEDPYLPNLWICDVNLTDDQELVMEHLIAHLNHPRVVSLQATANAIHALMPLKTVPENYMSSDTTARPLSSSSMQLRHPAARVMREFWCVFFDVAKNIPHWHPAQERLQNLIKNLADLYEAGAEVEKKEWMRRERDGLGTNVSLLPSHMVGALALLLGLSLQECFMASAAEWMKFAAHLLWQQALDWDNPASDKSGKKSSYIWDWGSPTGVMYGGEPGMHMDRWMHWYATFRSIIKKCSKLEEAKLVVHYAQVSMTAMDRVMGVPESNIVGADQSNESKGEVTGYLTCEDLIAEGIAGLRLGNSGTSGYGAVGDVVEGIAGLTLQPTVFKEEVVSSETTSSEKADAKTEAVAKGKLVIKSEAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9R7</accession>
    <name>A0AAE0J9R7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_303197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678908.1">
        <property type="nucleotide sequence ID" value="XM_062823169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9R7"/>
    <dbReference type="GeneID" id="87860323"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="326" mass="36159" checksum="F7A9EEC7E44A7188" modified="2024-05-29" version="1">MLPVSRGIPKIQNITNSTRHFFTKSNTMAPLTKTFKLNTGAEIPAVGLGTWQSPPGQVEKAVEVALRAGYRHIDTAYAYGNEKEVGQGIKASGVPREKIWLTTKLDNDWHKHVAEAIDTSLKNLDTPYVDLYLMHWPASLDKQNPKQVYKDWDFVDTWREMQKLLDTGKVKNIGVSNFGVKNMEKLLSAESTKIVPAVNQIELHPGNPSPNLVKYCTSKGIHCSGYSPLGSSDSPLYSLDSLAKIAGSKGKTVQQVLLQWGVQKGWSVLPKSVTEERIKANIDLDGWSLTDEEIAQIDEVHKTHSFKVCGDSWLPVKIFFGPGDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9X7</accession>
    <name>A0AAE0J9X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_251204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679107.1">
        <property type="nucleotide sequence ID" value="XM_062822462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9X7"/>
    <dbReference type="GeneID" id="87859616"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="863"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="944"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="957"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3340165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="968" mass="109518" checksum="2D437999BB44DE8C" modified="2024-05-29" version="1">MERLRSIAHEKWVRIGHHIGIQPRRLVTESHFKYQTVHYTLIIGLTIVGSILIYASHRGKMAYVDALFFAAGSCTQGGLNTIDLNLVNTFSQAVIFFLSWLTNPIAIGYYTVSLRRYWFEKKLQTIVQDAKQRRGTISKSKSQMRADMLSQAERGVAGREITVMHGSGSPRMTNDGIMLGSFKKPTYDSRAPPDQRDPDQPEDTRRQPEIRFAGTVKKSDGLGLDAIKLPPHRSDEEHIAILERQRNRDDEVLRIPGPRDMERGAKPRRVDDSAEEDDREPAQPTPTVMLNGRPQAITIEEPDRNKLHEKLTEDIVDDAKTFTHSFVPQINHLKFRKNTRTSTNNRVDEEVDVSKLQRTNSRMSRRASLSAMRSAFTRDKMEPTPYLSWEPTLGRNSQFHDLTEEQREELGGIEYRVLKLLQKIILCYFFGFFLVGLVGLLPWILKKDHWGQVVDQAGQNRVWWAFFTASSAFMDLGYTLTPDSMNSFNTAVWPLLLMSFLILLGNTGFPVMLRFIIWIMSIVVPRDSGLYEELRFLLDHPRRCFILLFPSGATWWLFFILIGLNVADVVFFVVLDLGSGPVVDLPAGIRVLNGFFEAASTRTAGFSCINLAALHPGVKVSYMIMMYISVLPIAMSIRRTNVYEEKSLGIYHNPESEEETASPSSDLSYIGSHLRRQLSFDLWFIALFFFMLAISEGTRIMDGQTDMFSLMFEIISAYGTVGMSLGYSTGNASLSAIFSTTGKVFIIMTLIRGRHRGLPYGLDRAILLPKELNSSSSEDDKVERQWSHASAMSTGRDAWSTASIRSRRRHWRQRSNDIGNQIFGALLHPGPPRTATPPDGHRHHHVVHPQTWHPVQFGSVGTARFSNRDSHQGATGGGGGGGGINPNGWHSMHRRATNPEQHHEETIHEGFQFPPDSDRRPESDQTDQTISDQNTLTEPPRLGVDYHPKVMKRKSEPSFPSTPTSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA79</accession>
    <name>A0AAE0JA79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_476791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678911.1">
        <property type="nucleotide sequence ID" value="XM_062827391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA79"/>
    <dbReference type="GeneID" id="87864545"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="400" mass="43844" checksum="299D6A9081F93A31" modified="2024-05-29" version="1">MASTSASSAAKADQPVAIVCVGMAGSGKTTFMQQINAHLHGKKEPPYVINLDPAVTHSPFESNIDIRDSVNYKEVMKQYNLGPNGGILTSLNLFATKVDQVLGLLEKRTAPKPDDPSHTPIKHILVDTPGQIEVFVWSASGQILLESLASSFPTVIAYIIDTPRTSSTSTFMSNMLYACSILYKTKLPMILVFNKSDVKDPAFAKEWMTDYDAFQAALQEDETNNAFGGAEGSGDGMGSGSGYMGSLLNSMSLMLEEFYAHLSVVGVSSLYGTGIDEFFAAVQEKAEEFKRDYQPELERRREEREENKKKARERELNKMMKGMSMGDAAGDVTVGDVNDGEAPEPLSTDEESSDEEYGDDPNDEYDREGLQARYAAAMQGEDDSVMAEASFAKYLHTQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAI8</accession>
    <name>A0AAE0JAI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_444153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679048.1">
        <property type="nucleotide sequence ID" value="XM_062825670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAI8"/>
    <dbReference type="GeneID" id="87862824"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="861"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="874"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="966"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118342" checksum="ABF53946007EA619" modified="2024-05-29" version="1">MPPADSQALNNNFSSDDLDFAPGGDTHGHPPHSDPAAFQTHPLDKLDTSNDALGSINAAHDLVDNHFADFQFHYDDDLDGSPMAGLGSTAFDDHAPDVFSTTSHAPSMNSITVQTSTYNNNGANTGNGGQRQQSMDMSESNTPDSNQNAGNSLEETVDEFGLVTAGSVDGSAPKAKGDKTDNTPAWSELKTKAGKERKRLPLACIACRRKKIRCSGEKPACKHCLRSRIPCVYKVTARKAAPRTDYMAMLDKRLKRMEERIIKIVPKSEQEGASNITRAVVKPAIPGTLNNVKQANKKRVADEAFGSDLENWARGPSKSKIDAPNRTATIHIQETEESKLLLEGGDALPSKEIQEHLAEVYFENIYGQAYHLLHKPSFMRKLKYVPHSRHVTSYYLTTYRAGALPPVLILSICAVAARFSNHPKLNSSPNFLRGEEWAAAARDIVTKRYEWPNITILTCLLILGLHEFGTCHGGRSWALGGQAIRMAFALQLHKDLEHDPVRQAGKTQLSFIDREIRRRTMWACFLMDRFNSSGTDRPTFIREETLKVPLPIKEKNFQYDMPGPTETLSGEVLETLLEDQDASMARDNLGVAAWMIKAIALWGRIINYLNQGGRELDPHPMWSPESGYAKLIKQTEDILTDLPDSLLYTPDNLHLHETDNMANQFLFLHIAIQQNILFMNRFAVSSPRGQPEQEIPKAFVTKAGAKAFAAANRVSELLKDAESHFVTAPFTGYCAFLSSTVHIFGIFSGNPTLEATSKRNLATNVKFLSKMKKYWGMFHWMSENLREQYRTCADAARQGTPANENPTSIFQYGDWFDRYPHGVSQSDFLDPATYKKKEKGDDAVLEQKPELHTVEEFFTTLSPQAGGGDGGSVNGSAASRQQQQAQQQQQLKRKAMARKISGLPQQNHPNGLDPIQTDFSAHQQHPPPTAEQIHSARLQHQRTFSGAGPSPIQTSGPGAGGGPPGSFNTLSVQAQQQAHFSPVSPVGVSHAHLSHHHPASFFPPDPFSLPAHLGAAHAHGMSHLDRQLVFGAYGGPTAAGLHHEPGLVGGGGGSGAGGWGGGGHDGDGSGRDGSLRVFQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAM8</accession>
    <name>A0AAE0JAM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FUN14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_550930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679419.1">
        <property type="nucleotide sequence ID" value="XM_062829772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAM8"/>
    <dbReference type="GeneID" id="87866926"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042258414" description="FUN14-domain-containing protein" evidence="7">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16469" checksum="98108EC386A2FA34" modified="2024-05-29" version="1">MATRIACRAAFRRNVVPVTLVLTTTFALASRQQPLKLDAFSSQQSRSLHSQKNNKEEWLNPETIKQLSSGSLGGFATGLLISVFSKTLVLLAGVGMVIVQVASRYGINLVDMLHLRNRVNSSKILKSLQHKVAFKLAFAVTFALSAFMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAQ1</accession>
    <name>A0AAE0JAQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_476658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678847.1">
        <property type="nucleotide sequence ID" value="XM_062827377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAQ1"/>
    <dbReference type="GeneID" id="87864531"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="49"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="608" mass="68930" checksum="1CDD05182C69F8D5" modified="2024-05-29" version="1">MASIYTEIQLEGNSDSIRILELAPLGPSLSTGVLHGRLTRAYLHRSPDYTALSYVWGPPEFTHSITLNDSHTVPITETLFDALKELASDKANAGGLSLWIDQVCINQTDDSEKASQVQMMSRIFRQANLVIGWLGPADTDSNEAMDLFRCFSLNTSSPEKTELGQDLRHRLKLEWTTDQEGRSVNPLEQERNSAGLACVAILYRPWFKRLWIVQELVLARKLELRCGSATISDSQFFTALESSEWKGRKKVGSFSKPLTERISSLRRLRDDLLTRNELLSFVSLAHDFQAWDCGNNHDRLNALYGISAWKNGNNSWFLPDYSISAMDLYYRFAEGYLKHTTGGLDILRYAGLGFFLASHLRQSNGAEWTCPSWVPDWRIRNRAKTLSFLGPFDATIDEAFFRVDETSKTLKVRSHRMDSISNMPQTIFSTTDRTIMQDIFALSQSYTGKKMEDFVSAITTEGPFSRPGQVSKQDQMVEAFKAWKERQERLEYVYAGHDESESLGVPYIPDDLADHFAAMALGLFRNRSFFETTNGRLGVGPAHVKEGDTILFIYGLRTPFVVRKCTADLSDSSYILMGDCVVSRYETYELGRARYSSSSYLHREITLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB16</accession>
    <name>A0AAE0JB16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_263675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679508.1">
        <property type="nucleotide sequence ID" value="XM_062822657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB16"/>
    <dbReference type="GeneID" id="87859811"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3340566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="424" mass="46093" checksum="FE1BC895CC0A7FE4" modified="2024-05-29" version="1">MSSLATTAAGTLRMRIPYRELPPPTTIIPATATTLPGAVAALKSFLTTPPPSGLPDRTVILTGAGLSVASGLADYRGVNGTYRVNKNYKPIFHHEFLTSHETRQRYWARSYIGWRGLGRAGPNPGHHAIRDLGDLLAQRYSSGGGDQNSNKSITGVITQNVDSFHKMSHPEIRTVELHGSLASVVCTSCKNQFPRDEYQTTLARLNPIWADFLREALASGALETEDIEERNKRGIKMNPDGDVDLAEAPYTTFRYPACPSCLKEPPRLGDGTKTRVEIDADGAWIPSSTAGVLKPAVIMFGESISAEVKRDAENAIDNAGRMLILGTSLATYSAWRLAQRAKLRGMPIAIVSIGGVRREEMFFEDLDPKMAGFHGVRVEMATEKLLPALVEELKSYNNGAMVTEVPIGTAFTSGSPNERPSLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBP9</accession>
    <name>A0AAE0JBP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_267957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679651.1">
        <property type="nucleotide sequence ID" value="XM_062822712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBP9"/>
    <dbReference type="GeneID" id="87859866"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3340709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="338" mass="36352" checksum="8C81D0F401A0382D" modified="2024-05-29" version="1">MAAQSKPAQLGPWGKATAGAAGAAFANVLVYPLDLIKTKLQVQVKKSADVEKQEATASSEVHYKGTWDAITKIKDAEGVAGLYAGMGGALLGVTSSNFAYFYWYSIVRTLYLKYQKSEHPSTAAELSLGAVAGALGQLFTIPVAVVTTRQQTQNKEDRKGMIETAREVVEGEDGITGLWRGLKASLVLVVNPAITYGAYERLKDILFPGKNTLKPWEAFLLGALSKSIATIVTQPLIVAKVGLQSKPPAARNGKPFKSFVEVMEFIVKNEGALSLFKGIGPQLLKGFLVQGILMMTKERVELMFILFMRFLSKLRSQRLGKAAALAAAAKVASPVIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBS3</accession>
    <name>A0AAE0JBS3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_473360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679696.1">
        <property type="nucleotide sequence ID" value="XM_062827202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBS3"/>
    <dbReference type="GeneID" id="87864356"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3340754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="402" mass="45195" checksum="649956757C42119F" modified="2024-05-29" version="1">MTHLSHHSIAYNRCRKACSAFHFPSWRALAPARPRPPSRHNTAACFLSISCSLTQTRFRTTTTQHISTSSPQYCKMPPAKKRKTEPEEKAEITQQENDVAEPTTEQTVTDSKEEPSATEAAPATTSSSSPPTETTTTAQSSSTPSASTSAADSAAAKARERAERFRALQARAKSSSQQNLKEATKESQRLQSDPSQLTALGRRHAIASHKLLKADIEDAGGDFERKRAWDWTVEESERWDKRMKKREAHRDDTAFRDYNQQAEKSYKRQLRNMGGPDLEKYTREKLAAIEKAAAAGTLEIVETEDGEMIAIDKDGTFFSTADSTQFAQHKPDKAAVDRLVADMRKAEEASLKKRRERMANNGDDADVTYINEKNKQFNQKLSRFYNKYTAEIRDSFERGTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCE8</accession>
    <name>A0AAE0JCE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_224839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680429.1">
        <property type="nucleotide sequence ID" value="XM_062822113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCE8"/>
    <dbReference type="GeneID" id="87859267"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="361" mass="38448" checksum="4CD519C639592205" modified="2024-05-29" version="1">MATTTETPNLVRVNHGDAKAFAIALLTASGVSARNAEITASGLVQADLRGVESHGILRLPSYLSRVRNGVLDPAAEPTLTQITPVVAQVEGHNGFGFPAAHLGMDTAIAMARVFGIGMVSVKHSNHFGMSAWIVKQAVDADMMSLVFTNSSPALPVWGGREKMMGVSPIACGAPGGKGEGSKPFILDMAPSVAARGKIYKALRRGEKIPTDWALDGEGKQTDDPAKALEGVMLPMGGPKGSALAIMMDVFSGVLSGSAFAGGVTGPYDMSKPGDVGHFFVAIKPDLFMSLDEFRERMDVLYQKVVNSEKMHGVDRIYFPGEIEQLNEEQRLKDGIPYVKEEIDALNAEAVKLGVEKIPLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCL0</accession>
    <name>A0AAE0JCL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_468075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680161.1">
        <property type="nucleotide sequence ID" value="XM_062826942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCL0"/>
    <dbReference type="GeneID" id="87864096"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="81" mass="8842" checksum="3861E3F5C415416E" modified="2024-05-29" version="1">MGQAIAPAGRLPERVRCTAWLLYTIPVGRVSLALPVSGVQHVRCVEDACKASLMMRSMYFLSLRGRCHGEQGLDGRALGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCZ0</accession>
    <name>A0AAE0JCZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_443407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680383.1">
        <property type="nucleotide sequence ID" value="XM_062825634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCZ0"/>
    <dbReference type="GeneID" id="87862788"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="254" mass="29244" checksum="7410BCC509B6169E" modified="2024-05-29" version="1">MAADRSTSPIPPAFRVNVPTEHPTPTHLKYWHYPELWDGDSTVSSVYWNDAIRELVIGNSAAVHNAGWPLLWIFPHNKKITPADAKELVSQARFAYRLGYTYQVLCRRENFCQGIPSPPSLKWVAFLNKNYLKDVTEGTHYELIRRFIQKFHEAIREHMATLRGQESNYNLVSEFETRFLEEGNLRAGTDEYEPDWFINPEGSIHTSSHNRVLPFIMGLFAAKADMVKVDEIARSGNAKEGLKDFSIRDFDNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD95</accession>
    <name>A0AAE0JD95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_238761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680845.1">
        <property type="nucleotide sequence ID" value="XM_062822289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD95"/>
    <dbReference type="GeneID" id="87859443"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3343052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="144" mass="16151" checksum="2FD775EE9BAE99DB" modified="2024-05-29" version="1">MVDREKHITMGNGVRPLDKDYSVDQLASILQLWCGVHEQDLVFGCLMRSGTINLYDNDNTTAATGIVWIYSSNDGQATADDYTDHYEALRRPTVSGSQDSKTSSSSSKKRCEFMICVSAGKQIANMLANSRRLLPIRLRCRELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD98</accession>
    <name>A0AAE0JD98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_429755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680805.1">
        <property type="nucleotide sequence ID" value="XM_062824841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD98"/>
    <dbReference type="GeneID" id="87861995"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3343012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="477" mass="52029" checksum="6C5A33D983B1ED6D" modified="2024-05-29" version="1">MLWGRVADSPRCGRKTVLLIGLGGTMLSCVGFGFSTSFWEALLFRSLGGITNGNIGVLRTMISETVKEKKYQSRAFLLLPMTFNIGIIIGPILGGLLSDPAGTYPDTFGKINFFTHFPYAAPNILSAVFLFFAMISVWLFLEEASLSHADHTLDSRAMVRDRGLELGQKLRGCFSRGDMEAFYAPLASTDSSAELELSPAVEENKSSGKPTYGDAGKQNQARRRYTQRLPFRRIFTRNVSFTLVANFLLAFHVGTFNSLWFVFLSTPVYDPTKTAASPNALVRNLPFLFTGGLGLQPREVGMTMAILGVIGIGLQLGLYPWLSARLGTVRSWRFFLLFFPFTYFLVPYLSLVPSSSPPPSPKDGIAVWMAIAGVLALQVVGRTFALPAQTILVNNCTPHPSVLGTVHGIGQSVSSFARTLGPMLCGFLYGLGLNMGVVGAVWWGLSGVAILGFLASLFVWEGDGHEIWLEGDEEDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDK2</accession>
    <name>A0AAE0JDK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_443966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681014.1">
        <property type="nucleotide sequence ID" value="XM_062825659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDK2"/>
    <dbReference type="GeneID" id="87862813"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="211" mass="22902" checksum="5911E36D8D70BA56" modified="2024-05-29" version="1">MAGPQPFKQPIDTPQNYHHSQTCETMGSRNAHCHSELSIVMSGLCYPREAFPTTITSAQRQFFGHPPLWGEILKTHLLTFCHEGHGCSIKPPAVLAPSRPVPAPRRAKAAGSPTSALSNLRDKYSGSSSQLLVLNISRSPAHHSKPCGIFFPEDRVYTSISSQCVLLVPRIVLPQSPPQLPANHHLMCSTPANETTTAFLAPMKPSVAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDT0</accession>
    <name>A0AAE0JDT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_471002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681134.1">
        <property type="nucleotide sequence ID" value="XM_062827070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDT0"/>
    <dbReference type="GeneID" id="87864224"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3343341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="233" mass="26647" checksum="710EB74ABC1A994B" modified="2024-05-29" version="1">MYRLATHTGFRQVPRSIANSAVRPALATPRFVQPIDVRAISSSSGSSGVRVSDRIKHDHAELEQQYKNIIAAKDDDTKVRWQNQFIWELARHSIAEEIVVYPAFEKFVPNGLQMAEKDRAEHQRVKNLLYEFQKMTPSSPDFRPTLDKLWDNLSQHIKEEEREDLPALEQHIDEAYSGKLASSFSTTKHFVPTQSHPSAPNKPPYETAAGMLATPLDKLMDMFKKFPKEDMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDW7</accession>
    <name>A0AAE0JDW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H65DRAFT_239296</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680863.1">
        <property type="nucleotide sequence ID" value="XM_062822296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDW7"/>
    <dbReference type="GeneID" id="87859450"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042281975" description="Crh-like protein" evidence="20">
        <location>
            <begin position="18"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3343070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="366" mass="38598" checksum="2062FB7B05175D01" modified="2024-05-29" version="1">MHIKTLTALALASLVSAQTYTDCDPTKKTCPNDKAVGKEIINIDFTKGENSFFKNMVGTTLQYDNKLGAIYTIKKETDAPTVASSRYIFFGQIDVTVRAAFGKGVVTSFVLQSDDLDEIDWEWIGSDSAQVQTNYFSKGCTEVYNRGGFSAVANPQNEFHTYTIKWTPTQLDWIIDGTVVRTLLASEASGCSGFPQTPMQIKLGTWVAGRKDAAQGTIEWAGGLTDFSQGPFTGYYQSIKIQDFMGGDGTTGPTDATEYQYGDKSGTWQSIKVLQGTSTDNVDTTTNAPSKTGTAASTATTLSTVPASSASSAADSSVSSLPIDSTLNNNNGTSSTGGNVVTGGAGKLAMSIASLGAALFAGAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEJ4</accession>
    <name>A0AAE0JEJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_573444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681525.1">
        <property type="nucleotide sequence ID" value="XM_062830548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEJ4"/>
    <dbReference type="GeneID" id="87867702"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046925">
        <property type="entry name" value="WD-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20493">
        <property type="entry name" value="WD-like_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041916103" description="WD-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="WD-like" evidence="3">
        <location>
            <begin position="78"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="220" mass="24365" checksum="EE7C3B3B7AB404FB" modified="2024-05-29" version="1">MFSLKIFVTVTTLIASYVAGAILYEDDDPDLILAGQVETQFGLVSWFKDNTPTDKSAPVDKTRDPIRRGPKLHKRCGSNTVICSGKHAADVLVCETLVRGVFPLQSEMIPEDDHRSICLEQVGKRCCINWSKNPQGAFYQDLIDAAEKQLYTCQFRGQVSAKSKDVLLGYVCVNQCMASWNHCSGPEEDSSFKDGTDKGHGSEYADHPVVEILPLPKPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF15</accession>
    <name>A0AAE0JF15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RHO4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_185840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681406.1">
        <property type="nucleotide sequence ID" value="XM_062821568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF15"/>
    <dbReference type="GeneID" id="87858722"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RHO"/>
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    </dbReference>
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            <end position="87"/>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <name type="scientific">Neurospora tetraspora</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062826816.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JFZ2_9PEZI</name>
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            <fullName evidence="5">GRIP domain-containing protein</fullName>
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682058.1">
        <property type="nucleotide sequence ID" value="XM_062828284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFZ2"/>
    <dbReference type="GeneID" id="87865438"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
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            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="664"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="154"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="795" mass="85796" checksum="0A48C48035BBE945" modified="2024-05-29" version="1">MSIRQLHVYKTDATPRTQPDIRIQKPSNHVVRGSDLQRLEEFGVPTPKHSGQGSDTDAHHDSNGGQSASLTMSPSAPVTQSAGQVSSSPAPLPANKKKKNNKKKSSAAASNNKAKPQEGGGSNAPDAAPDAEVLSDQPPAPPPQQAEVEAAAAEGTEDTEETTLPVEETPASLNTSPKLDQVEAPAEDEDTDAEVPATAADHPESENPPPPPDGDSNPAPDPDPESESESAANPAEDTTATTPTAVVITETNGHAPDGANGHIPNPSTTTTATTMSTTTSPPPTEGSPVTNSTTADETPANTTTTTNNSTDTSAKLEAMSQDRETLRAEVEQLRKQLESIQSTHDEEVSQLRSDLEESEAAKEHAETQYQNLLGRVEKIKETLGERLKRDRARVEELETANEELQQAAQTQEEEAARLREQVAEQAREIDGLRSRTNLSQQNWGKEREDLEREVEHLRSELKKTSAAMGEWEVIAMEERSMREGLEAKATDLEEQLANVREAYERVAEERNTQSQAIDGLQRALQEIQEARKRELREMVESSEEQLAAMKKRAEEADAKAKEAQDARESLQKELERTAPFEKEVKEKNLLIGKLRHEAIVLNDHLTKALKYIKKMKPEETIDRQIVTNHLLQFLSLDRSDPKKFQILQVIAGLLNWTDEQREQAGLARPGGSGGGLGSASSLLRLPTSPFHRTPSSPSLNHDFFSDMSTHNSSTMSPTAGSVREGSGSTGGGGGGRESLADLWAGFLERSVEEASAQPPNKRKDSMSSTGTGNTSGGTHRFGKGGGGEGKGPLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGJ2</accession>
    <name>A0AAE0JGJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_549394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682328.1">
        <property type="nucleotide sequence ID" value="XM_062829658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGJ2"/>
    <dbReference type="GeneID" id="87866812"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="98" mass="10966" checksum="FA5D1027DD928801" modified="2024-05-29" version="1">MSSALVKVSRFIFLVLTITFFIITFFFIVAQNPPLMTPYNDTNTSRTYHAVDRQTTNSRSSNTTSKNKTPMERFEAESFTNGPWHAIDGVSHSGPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGM9</accession>
    <name>A0AAE0JGM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_460665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682604.1">
        <property type="nucleotide sequence ID" value="XM_062826550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGM9"/>
    <dbReference type="GeneID" id="87863704"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="701"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3347522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="766" mass="82723" checksum="B27091228DE1D5C7" modified="2024-05-29" version="1">MFWSPFAAGVPDPPGLLGLMVAAKRLLKDRPSSTLVMDNGEGVSLVVDVDGDDMDSNNSRFAEAANSTTGAFILGLTPVEYWSNASVRATVDECLGAAAQLYDDDDDDDDVYAAGGGLGEGAGVKEKEKEKAAARVKKLEENGLQISNRLLRKHSRWLNPGQHGGKWRKPTVVVDAKELAEAAWRVYQNLVVFQIEGQRVVHQGQELVKVSWGEGLWQTLLDFLGVVCGQFETDREEFRRAILEKIGGNSVQDALLKKALEEVSGSESTTATEAEADGCPVFTASFDVSSGILKTITGHLDFITEEDKRLLADKTVPISLRQSSPWTIDIVLGAGTLVKPLVFPTPVLKEGSKTRIARTSGYIEVIAPAILNPRSAIPASVLDEYIFPTVLQATDPSSESSQLIPVPLNAATVNLDSLPILSLSDASRLSFLGPLASSIYSPRELRVRQAAFEQSLDESSWGSARLTLKESFLTMINIAAGLQVGQSGLFALSPVSGPGSGSSSSDGRHILILVSAIRLDCSAQSGGGIILDAAVLPLTRSLLDNTKKSASSGGGDGGDDDDEEDLQSFLVLLRTLECVDLTVTDAELSLWKSILPSFAERCRTWSHSPSSCEYVTTGGHVPLSLQKGEPVLCTCGTGHFPPNYLSLPLWESAAARHATRVAISAPYCSPTVERVVFDPVLARKIAERGLEEALRKKEERCRCCGKGEEELVEELKAKGGETAGKTAEVLRKCARCLKVRYCSAECQRRDWKTHRTECVESEEHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGS0</accession>
    <name>A0AAE0JGS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_441203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682675.1">
        <property type="nucleotide sequence ID" value="XM_062825509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862663"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="9"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="941"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2388"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="941"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2488"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2488"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3347593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2972" mass="326984" checksum="DB3C32568E89221E" modified="2024-05-29" version="1">MPSSTSPLNEPIAVVGSGCRFPGGASSPSKLWDLLKDPRDLSRKVPKERFNVDAFYHPDGSHHGRTNARYAYFLEDDPYAFDPAFFNIPPSEAGTVDPQQRLLLETVYEGLCAAGLKMEDLRGSPTAVYVGMMQRDFLDHQNYDLDALNTYAATGTAASILSNRVSYVFDWHGPSMTFDTACSSSLVAVHHAVEQLRTGLSKVAVAAGSNLILGPVPFISANGYARGEGVATVVLKTLSQAIADGDRIECVIRESGINQDGKTAGITMPNSLAQEALIREVYERAGLDLTKPEDRCQYFEAHGTGYLSLIRQYSTGTPAGDPQEARAISSAFFGDRHRDADEEDPLYVGSIKTIIGHTEGTAGIAGLIKASMCIQNSSLPPNMLFNELSPRVAPYYTDLKVVTEQQPWPPLKFGQPKRVSVNSFGFGGTNAHIIVESYEPKPESKESPSTDTTTTPTPLLAPIVLSAHSSSSLRSAMVDLKQFVQARPDLRLRDLAWTMLKKRSNLQVRHAISSQSVQELCDALERDAPLVEGKSSIATTSEVRKKPEILGIFTGQGAQWPAMGKALCQIAHVRAIVSELDHSLQSLPAEYRPEWKLLDQLLLEGEESKVNQAAYSQPLCCAIQIILTKLLQASGATFKVILGHSSGEIACAFAAGFISASQAIRIAYLRGLTSQYARGPNGVEGAMMAAGTSFDNATELCALEAFAGRVVVAASNAPESVTLSGDRDAILEMQEVLNEESRFNRILKVDKAYHSHHMRPCSDPYITALKACGCDVPEMEATPSVTWISSVFEGHVMTPEDLKAEYWGENLLSPVLFSYAVEQALVKHSPFDVCIEVGPHPTLKGPSLQTIENCAATTLPYTGCMDRNKTDTEAFSACLGYLWSQFGSPAIDIDRLLGELSPDEGITELSKELPCYSWDHSRSYRKESRLLRQWLGGDRPHLLLGKQLSQSSPSSLQWQNFLRQRDIEWLSGHSLQGQTVFSGAGYVVMAMEAAISVASSSDKEIQLLEVLDLEINKAVTFHDDDSMVELSLSLSCDSSQTTDTYATYQFVINSCLARETRLSSSASGTVAVTYGPGSSDTLPARQEDPPHLNNVSIDRFYNMLSELGYGYTKEFRGVSILKRGDSKARGTLDFHRLEDNDRKLVMHPATLDVVFQSFIGAYTAPGDRRLRSLLVPTGIARIALNPWVADRISTSSNQQVDFISTSAASVGNAVEGDIEVFDPESGATMIHIEGLSFKPFSAPSAADDHEMFSKWEWAPINADPLLDDSKYHATEQDKTDVEIIERITYWYIKSFITSLEPEDRERAPFHFVKHIQWCEHQLAEAKAGRNVWYQPSWEKDTKPFIEQLIQENRSHPFVRLIQRVGEGALETLRGNRNAFDLMDHDGLLTEFYGGTMLLEQINHRHQNLDVLEVGAGTGGATRVFLNDDHLSFNSYTFTDISSAFFEQAGKEFERHGEKLIFQPLDIRRDPSEQDFKPNSYDLIIASNVLHATPRLEETLSNVRSLLKPNGRLVVMEVAHHEHTRIGFIFGLFPDWWAGHDEGRVLEPFISYDKWDVVLKKAGFSGIDSRTLDPDSRIFPNGVFMTHAVDDLVRRLDSPLSAPAKGEYPPLVFVGGSTPKTSAILDRIPDVLAPLGREFSTCPSIRDIIDFDYQPGSSFVVLSELDEHTFAGLDEEQLDALQTIFNAALHVLWVTEDAWCTNPQQAMTIGLLRTLRMEYPDIHIQVLDVDKAEHVEPRFLIETVLRLEDAKDWQERGLLWTQEPELYLSGGKVIVPRLKPDVEKNNRLNSNRRPILADLDPSKDTLSFENDGRETFFKNHEERFVPLNATEGESSIKVQAQYSLAKALRIGQSGFHHLIQGKDVATGEVVVTLSQSNMSSLRVPSSRVVKIEGEKNASPVLPSIVAELVASSMLSDVAPGSSILVFEPPTLCIHALSKRAEAAGIAISFASTRAKPSSGIRWILLHEKETLRSLRQKLPQDINLLYDLSSDQSPASLSQRLARRIPAGCVIRHRDYLFQDITTQNKSAVGAEKAYQALVEAVARAKEMPPSDDGVSIIKGSDIVLLGNAALHIDTLIDWESEQIIPSRIRSMETDPIFVSDKTYLLVGLAGDLGRSIARFMVERGARHVVLSSRSPKIDQRWIDDITALGGNVMVLPMDASKEASVDQGLAKIRESMPPIAGVAFGPLVLQDVMFKNMDLSMLEMVLAPKVEGARLLSERLSDPAQPLDFFVMFSSFVMVSGNPGQAAYSAANAYTHALAQNRRARGMAGSTIDIGAVFGVGFIARAGREHEYDVVKFIFDEVNEWELHALFAEAVVAGRNKQLADVEVITGMPYMDPANHDRIPYFDDPRFAYFKLSDRSAKGNNAADAVGSVKDQLLKADSMGQVRSIITDGLCVRIRGALQLTAADELSLTTPLIDQGIDSLSAVTVASWFSKNLSIDIPLLEILGGASVNDLIDSAVGRLPPEAIPLCSDGSLDQENAVQVPQVVESSAVSDGSSSSSAEHNHDLTPPSAFESGGEEVTEREAPLSLTQEYAWKQLQLPLAPETFNSTIGMYMQGPLNLDRLSWAVKQVLQRHDAFRTAFVNDPADTGGPIQFIMESPRVAFETIQVADKAAADQGFTDLEGYHYDLDKGDTLKLVHYQWSPMDHLLIIAYHRLVGDGWTTEHLFVEIGQLYSGVKLGPAPSYADFAIRQRKQLESGALAKDLSYWADLFKQPPARLPTLNVPEAKADSTPTAWSEHEVSARLNRMVGVRIKDRSRKHKATPMHYYLASFQILLARLTGSADIVIGVADSNRSTLADQATMGYFANLLPVRLPYDPDKIFHEALSEAKEQMRGALLHGAVPYGALLDHLGLPPPSSQDAHSHAPLFQAVFDYKQGQAESGNIGDAKIVDSRTPRAGSPYDITLEMSDDPTKAPLITVKLQKEKYGLRDAEVVMDAYLSILSIFSRNPALRVADGRLNQGAKAGDTKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI14</accession>
    <name>A0AAE0JI14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0H65DRAFT_441780</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683322.1">
        <property type="nucleotide sequence ID" value="XM_062825547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI14"/>
    <dbReference type="GeneID" id="87862701"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="809"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="22">
        <location>
            <begin position="1114"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="677"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3348240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1250" mass="138403" checksum="F69A2450BF2CC5FE" modified="2024-05-29" version="1">MWMKEKKLDAELGPIRNGVSTVGWMKVCFGLTSISIRIVVPKMLRRPSGHVACRPEVILAFAFLLVNLQWLQLVDAQPQRHARSPREDDDHAAPNIATLSTLTGGHPQAVIETPRTHGRGKRTVVEIADGPKTESIRLSYHAQSDNNNNNNHADLISNNVRANALAPDSSVRAPPTQYNKVGSLGAELSQHQIARSLEDWEVEDFVLLATVDGDLYATDRIRGEVRWHFKADHPMVETRHFRTTLSPVDEDYHEIDHWIWIVEPTRDGEIYIWRPSDSGPQLTKMTMTMKQLVENYSGLHMNGIVYTGEKRTNMVTLNAATGAMIKNLGPRGVNINKIESERCLREYALGNSITSECSNRETITLGRTEYIVGVYRTDGSPIASLKYSEWAPNVLDGDLGQQHSATPDKRYITGKPDGTFFGFGLDRESGDRPLFSQQLTSPVARVFDVLRRQWNPTGSSDTDLIILPQPLIPVNPGISRLRSGKVFVNHTEEGSWYALSGTQYPLILHAPPAPIHKYWPLEGMDEDKLSEALVGTHDLPDWRIPKEINRLVPLLDAPPPPAGDAVITGNPTLPSSAGALPGIPAPDTATALPVQAFDFFRNPFTLLVGIVVVIAVWTRAWIPQSSKKGYSLEGFVDFTRTLGRKVVDLSRFRIHVVRTEPTPTVTDVTPRLEAAKAEISKPDTSSPDPSAGDSGSDEGLAKKEVTFADLPKSSETPPSGDANDAPAETVKPKKKAHRGRRGGIKHRKGPRSENTQSRDDEPPEPTVDEVVKKAKEIGQQPNLEPDVITIPNGVDNVSGPILKMGSLEVNQEQQLGIGSNGTIVFAGKWDGRAVAVKRMLVQFNEIASQETKLLRESDDHPNVIRYFAQQQSAGFLYIALELCQASLADVIQRPSMFRELAQAGERDMPGVLYQVAKGLSHLHSLRIVHRDLKPQNILVNMGKDGRPRILVSDFGLCKKLEGGQSSFGATTAHAAGTTGWRAPELLLDDDGGPGPGAMMTFTDPGSSMHSASGTGSGVVGAGVNVRRVTRAIDIFSLGLVFFYVLTKGHHPFDLGDRYMRESNIRNGKYDLQLLEVLGDYAHDAKDLIESMLNTNPKKRPTAIGVMAHPFFWSPRKRLNFLCDVSDHFEKEPRDPPSPALALLEEQSPCVITNGDFLKTLPREFVDSLGKQRKYTGNRMLDLLRALRNKKNHYEDLTPQLRKMVGPLPEGYLSFFTTRFPNLLIKCWEVIADLDLEESDRFKEYYEPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIG2</accession>
    <name>A0AAE0JIG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_548286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683595.1">
        <property type="nucleotide sequence ID" value="XM_062829568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIG2"/>
    <dbReference type="GeneID" id="87866722"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="100" mass="11095" checksum="126FE2B02D6A8162" modified="2024-05-29" version="1">MLEDKNAFGFVRHNPRPPKPRKVGVTEIRGPYYSAMGKRYLQDGGWIEHILTQSPPPPNTAASSYLAHCKSLGFGVIEKSPVHRLPLPPSLPARRHIGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JII7</accession>
    <name>A0AAE0JII7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_171104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683368.1">
        <property type="nucleotide sequence ID" value="XM_062821379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JII7"/>
    <dbReference type="GeneID" id="87858533"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3348286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="575" mass="62906" checksum="F9D687DDD45F0C0E" modified="2024-05-29" version="1">MIPARTVAAPFSASASVSVSVTTVIFRIAWYLSLVALFYSTCVASASINAVRRGGDGNGDGGVFPAGGTRSLNLPLIINHQAAPPKKRSTTEHVILCDCISASGIRSSQMAYYSAQVSGLPTGGVGTVDTAFNTTAGWYNDTTSATWADTGVTFKAVIGYHVAEDDYVGKGNNGYGEFSCWQRAKTGFAYDLNGDGNVCEMLIDCNKDAAPSTNPAYVPLESTTTTPTDNNGQAAGSSSISTPATFSSSSSSSNPGGNAQQPAAAGKKDKAISTGAVIGIAIGIVGAFTLLAGGAGFFLVRRRRIRKRQREQEQRQRKGARTESTMTEAYAPGSDFVKSGDPNAVHELDGGWYRRHEMGDDTGHYEIDGQVRCEMDGDGGEIKEKMDDLFAEADVKEVIMLNEKADSKKVMLDEKKEKKGYVVGVSEKEKEVRRDKEEREREWQQQQQQQHHQEQNQQLEEQKRNRDAEELPPVSPATTTSWTEEVGQTPFCLPAMMPELEKFMAEEFRAHKEEKKKKDETNIKFRLEEETQKYMKVEILPAGEGSTHMTRPHTQSFLTQVDTPRPTPHYEKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJD9</accession>
    <name>A0AAE0JJD9_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_90275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683798.1">
        <property type="nucleotide sequence ID" value="XM_062831542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJD9"/>
    <dbReference type="GeneID" id="87868696"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="86"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3350503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="629" mass="67552" checksum="E171DDF50D83D412" modified="2024-05-29" version="1">MNIMEKGTTDEIVMSDPSPTTSTPSPLEKKTPLETITPVSANSSQTALDTVAEEQPAGEPTTLVVAFAPNDPENPHNWSSTKKFLIIVATTLASTNSGFGSALCSNLSPLLSKVFDFPSPGPQTILPTSVYLIGFVFGPLICAPLSETYGRRPVLVTGFSIFVLATLGCALSNSWALFLVMRLIAGTAGAPPISVGGGVVSDLFGDKIMRGRMMMIWSASSFLGPLGAPILGGFLGRSKGWRWVFWFALMLAGVSFCAVASMPETFHPKLLKIRAEKLNKQMEAEGKAKEVRYIAPVTGLGNADGEKMGVWRQLSITLSRPILLLCNELLLGLTCLYLAFVYAVFYMMLKIGGAIWSGTYHFSPGIAGVAFMTMGLGTIIACFVIIWYDSYGPKFAARFPADRKSEYLRLPVACVGGPIFVISLLWLGWTSRASIHWAVPLIATVPYGFAYHMIFTAMINYVTDAYSPLNFAASALAACGTTRSIAGALIPLAIDNMLAALGVAWAITVLAIISAVMCLVPFAFIIYADAIRARSPCSRLGGLTAEDLGAESDEEEDVEEGGNGEDLEKGTGAALKRERTQKSQRTVRSHRSRMSRMSRMSRRSGRSILEMSGANEVGMGELTRSLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJK3</accession>
    <name>A0AAE0JJK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydantoinase B/oxoprolinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_439753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684059.1">
        <property type="nucleotide sequence ID" value="XM_062825439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862593"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="250"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="571"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="778"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1369" mass="149357" checksum="5ECBCDBB90AF7548" modified="2024-05-29" version="1">MGSSQKDRGVRIAIDRGGTFTDCVGNYNGEDIVIKLLSVDPANYDDAPLEGIRRIMSHFLKKEIPRGQPLDTANIDSIRMGTTVATNALLERKGEKIAMVVTKGFKDCLVIGNQSRPKIFDLAIRKPEVLYSTVVEVDERVTLEDYAEDPERHITKVDVKAGTAEAKDADLVMGLSGEAVRILQRPEKETIRAKLQEIYDSGIRSIAVCLMMAYTFPDHEALVGEVAREIGFTHISLSHELMPMIKLVSRATSVCADAYLTPAIKKYISGFQKGFAGGLGTKGVKESGGEAGKGARCEFMQSDGGLVDVDKFTGLKAILSGPAGGVVGYAITSYDENTKIPVIGFDMGGTSTDVSRYGEGRYDHTFETTTAGVTIQSPQLDINTVAAGGGSMLFFRNGLFVVGPESASAHPGPACYRKGGPATVTDANLFLGRLLPEFFPKIFGKNEDEGLDPEASRIKIQKLADQIKAETGKEMDLDEVAYGFLTVANETMTRPIRSITEAKGHDTSKHRLATFGGAGGQHAVAIAESLGIKQILIHRYSSVLSAYGMALADVVDERQEPDSSVWKVDDQSVIQGLKDKMEALKEKSRQALRDQGFEDDQIVFEEYLNMRYRGTESALMIIKPTAEDAEKHYNGSDWDFASAFVRHHRYEFGFTLEERDIVVDDVRVRGIGKSFRYEEKSVDEQLKTVQKKDVNVANKHSEAKVYFEGGRMDTPIYKLSDLSVGTVIKGPAMLADGTQTIVVPPKSTALVLETHVVVDSEETDKSKDEKGDGEREVDPIMLSIFGHRFMAIAEQMGMALQKTSVSTNVKERLDFSCAIFDANGGLVANAPHLPVHLGSMSTCVRRQAEIWKGKLRKGDVLMTNHPSYGGTHLPDVTLIMPAFNQAGDKVLFYAASRAHHADIGGITAGSMPPHSRELYQEGAAVKSEKLVSEGKFNEDRVIELFHKEPAKYPGCSGTRCLADNINDLRAQVSANQKGISLIETLIAEYGEDTVQFYMVAIQNNAEQQVRNLLRTVHKRFQGQELSAIDYMDDGSPIQLKVTIDPDAGEAVFDFAGTGPEVYANINAPEAISYSAIIYTLRCMISEDIPLNQGCLVPVTVKIPPKSLLSPSDNAAVVGGNVLTSQRITDVIFKAFQAAAASQGCCNNLTFGFGGNVAGEKEVKGFGYYETIAGGSGAGPTWEGTDGVHVHMTNTRITDSEIFERRYPVLLREFSIRKGSGGKGKHRGGDGVVRDIEFRLPLQVSILSERRVYRPYGLAGGEDAQCGLNLWVRKVKKARWEDTLRKIQNGEQDQEEVVGDEAEGYEERVINLGAKNSAPMIAGDRIIICTPGGGGWGKSGEEREVDETRDPMGTWKMGSHGARMDLALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK45</accession>
    <name>A0AAE0JK45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_586435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684432.1">
        <property type="nucleotide sequence ID" value="XM_062830951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK45"/>
    <dbReference type="GeneID" id="87868105"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="231" mass="26061" checksum="FFB2358720589350" modified="2024-05-29" version="1">MNRGKIRRRAQQGCHPASDYSSPWTETSLLNCHVTSPSPLVSEPYGSNALPIHQNYGIERPLVTGPVYSLSAESQGVGDYGLSLPPQPERRQCLQDWGFSMPGQFIGTIPGHERSSSLEANIPPIPYEFEGDTHVEDEEDHVEWSLTKEATEDTQGFPEQEIGTRYLACPFYKHDPKTFSKPKWKSCAHLGDENMHRLKLVTLWTTLNGVIRPPLNFPSRKKQFKKANSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK72</accession>
    <name>A0AAE0JK72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_101121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684158.1">
        <property type="nucleotide sequence ID" value="XM_062820439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857593"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056416">
        <property type="entry name" value="DH_2_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056222">
        <property type="entry name" value="PH_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056223">
        <property type="entry name" value="PH_24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24340">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24344">
        <property type="entry name" value="PH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24345">
        <property type="entry name" value="PH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBL homology" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1213"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1556"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1541"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1745"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1796"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1809"/>
            <end position="1849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3350863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1995" mass="219946" checksum="31B60F38309A13A6" modified="2024-05-29" version="1">MSPPKPKPDKSPSPRPKTPKITPTNSKNGAPTTSPTKSATAPGATTPKSVPIPTNSGLSQQKKKPELKKPEPSLLGDFLLGRPSPQRVAAQRSASIKRRKTMSMDAQNVREELRQEMRAAAVRKLQQPGGVRDRVKAWQKASQAAVKAEGLPIPVAEDAGSEPTEFAVNLSGDDVDEEDRMRIKWRQKPKKKKPKVETVEPKGVSGSDSTAKEKKKVPGKLADDRPDVIVKEARPRPGLPKKRIISDDHWMKKQQKGKGPAENPIPEAGQPIPKDFLKRTAQNPSVQKKIRDWAQRVELPPPPPPVTKRPTVKKYRHAKTGETVTVEEEEDDDHHRGALSEPDMPRRKRSSSGERRRASPKPRTQQRPPDDGIRVRPLRTRGSNDDGIRVRPVKPARSLPDVRPGPPVSADSSSGSTSTSSPSSSSGRTPSDRPGSRTPPRRASPPLRRASTPPRRASTPPRKASTPKPRARSDHSAASDDVIEVIVEPESEASSPRSPSPPPKRRLRSPPPPKRKSPRRRGSRGGVRRKPKRRSPSPPTTATQTETTTDDRRPGADKPRPAPRNGVSSGEDSDRRPPTAAGIDDLAEIPFGFSAFSELDLPLRGNPGGTHARQSAKPKPKPQRNESLKLVPNVLKKVMTGAMEKMQEMAQEMAEPPRPPPTGNKPARIESWLNNTVDPFVEGMPNLPPVVAPEPLRVSTPARNSKEKLVDRDLPAHKERAPEISKRASAEQPRRKERPQTPVTHEEPRKASETRSDDSEVTPKRRKSPTTTPDSAAVLKRRSTPRSPTLPRRSSGPVKKPFRDVLKEAFKGESSAHKIAPMVYPSCETDVESEPETEDDLESKRSPPQQRSPDSYKRRSASPDRPSTADSYSSSEPSTRGPPRRRRPTSGAHDLSTILSEDSREDQEPHGKKDTDSVSTVSQSTVTQTPEEAFGQPTPLTREASQQSQNSQRSRKSGSLKRRLTTKHSDLVSVLSLPDDGQLVPPSRSRSIKASRSLHRKPSKANDSRVKDLLEEFADDEHFYHRELKTLVDGVVPVLLNEFVHGDDVDDADRKTDSMAKAVVNMGVALEKMWTYHKRAPLHDIRRLLEWLEAVSPVYNNYLDVWRLGFQDLLVNLAPASGRVDENDSLLNALPRNEDGDVLSYNGERVDVAYLLKRPLIRIKWMYKFLRAAVMVIKTPETEDLLKLYGNLQEKARTRHREEFARLTDEDANNTDTTRARDLRNLRPLDSVRIDPTRQVAAKDSFEMDLDHSSGQRLECQIELMQRDRVNVPSDMGDILIRDISNKAKPWLLFPPVPRQYISARKGESPRSMIVMIRGRHNGDEWYELIKLSTTEEAQTTDWLDILGSDPMPPLSRPKPRMSMSLIQVSSPKADDLDVPIGEPSVIGASDDESKTPSRYHKRQASAPVTSYPAPNKHIPYSESVDIFRSQPLTPAYGIEPVPIPRPLNIKGAAPVQPPVELAPSTRVKRRTSSPLKHEYHPSDTDSETEDSALSDSESSSSSSDELDENDVPDTIPGYSIKQPLPQIVEESVVSDNTIAPSQSASQVGAPHPGQQTPRERPVQSFVASVSFWSNRKGIWREINTEPSRILIFPGSMEVHMLHENPENKQAYPLQASGTSEVDMANREAGGIVPLICLVLTPVVMIRRSTALDLEVRSRVSPESRLSSIDSGMFRFRAASQDEAKALYEAVHQSRLNNARYIQLAEEARVRSFGQQVYNDSGAGSADGTETSSRRKGIFGRKNSYRASTRAPSQHSNATTSVSAISFLRRLLGGENKSFNIGKSTVDKQSRPGSIAGSGGAHGGGGSGSLYSSGYSSGTGGNDSSTPPRSASASASGSGSRSPSRWSTGLAKPFTPGQPLEIRCHLNVQNNRWADKGDCILHIGRPPPGVRQELSLYHGLEKRIIVTHATKKVSDKPLILLDAVLGSKSFSMLGTKGIMCSVWENLRDEEGNVGLAPRTGTVAGRVTKWCFQCKSVQQANWIFGMVTSEVEGLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKB8</accession>
    <name>A0AAE0JKB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_421465</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684537.1">
        <property type="nucleotide sequence ID" value="XM_062824344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861498"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12302">
        <property type="entry name" value="RRM_scSet1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="1171"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1297"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="400"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="555"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="710"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="843"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="934"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="559"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="758"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="868"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="895"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3351242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1313" mass="145716" checksum="3304DFCF689C0968" modified="2024-05-29" version="1">MSRSSGASFAQFFPAAPRAARDRATERERARLRAQASPPTQPVDTNGHRTPLSSFTSNRSDDGASPGRSHITSLNHSSSAGADATRPPLEDTESLPGDTLNTVGSASSHASTSSSIFSSSTRQLAMASASVRNSHTHNSTTPLTTADSPSSLYLSTSLHAKPHSVSPHHADKQNGLTPTLNGSATESLVPLPDGTERVPPRDPSRSVLCTICTYDPLLDKKLSSSEKKKAKPIYKDYGLNDEDDAPPSDPRLAHGGKLSYINVNFHLPKAQLIDAPSNLKPYPYDPKTSCGPGPPVQILVRGFNPLIAFTKVTTIFASFGDIAESSNKMHPETGSYLGFATIRYKDSKPTPSRPVPVPAHQAARRAVRGMHGRRIEANQVRVEFDPEGRKSKALMEAVLKKSRETSQTPSAAYKIPTGPKPRAGEVIPGPPPTAPKGPAAHRALGGSEAGWTSTKPRHPSIIETEPIINHIKSEPYIFVAHEYVPVMPTTVAHMKKRLKQYGFDDIRADRTGYYIIFRDSHYGRDEASKCYNSANDTAFFTYSMVMELHLFGTVGKSSRSSEDHRRHSYSSEKRPPPEHRQRDDQDRRRRDEEADIEEEKKQRAKNLDPVKEAAEVIRREMTEHLLKTIRTKITLPAVFDYLNPVNHAAKRRKLNIDDSHSGTIPSIVFDDSEDRSSPVGTPNSRADPIERRTARADVSTLRVRKLKSRGLNARKHGFNDPFARARPTQRVDLRSLHHRLNSDSDDDSDDGVDNRYSMIRDTEEPESRPRSRMSSEEDRNKEEIGSWVAGEDDSMTEASFALNDTSALLKKRKLDLPVETAIKRQKKAEELFEATITRIETELPSQEQAVESATLPGIEAPLDGLPDADVKAEPAEDKETDDSRLPTPIPDNTKPKKKAKAKKKSKKQIFEEREALKKQQQEIFEREALRAAGIEDIEATPDVEAKSQVGEPEPVPEPELETKGEAPEAPPTESKPDLDPELYPSEAVDALVLPKDFHLDIGTLKVVPLQGEDGPDTQRLQRKFGTGKLGCDAELWLWRRSRIRQLNSEDGSTDKPVGIGGYYVPNPTGCARTEGVKKILNSEKSKYLPHHIKVKKAREEREKNAKNGNTNSVAAAAEAARLAADSLVAKGNSRANRVNNRRYVAEINDQRKNFGQDSDVLRFNQLKKRKKPVKFARSAIHNWGLYAMENINKDDMIIEYVGEEVRQQIAELREARYLKSGIGSSYLFRIDDNTVIDATKKGGIARFINHSCMPNCTAKIIKVEGSKRIVIYALRDIAQNEELTYDYKFEREIGSTDRIPCLCGTAACKGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKY3</accession>
    <name>A0AAE0JKY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_439840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684157.1">
        <property type="nucleotide sequence ID" value="XM_062825449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKY3"/>
    <dbReference type="GeneID" id="87862603"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="275" mass="30806" checksum="1EDBD857A25592C6" modified="2024-05-29" version="1">MPSSQSFGRGALRDSWPPTQLRIDHGDFHDVDLSNIDQDPLTYFLTPTPAADAVDDDDMDFDMDFDAGIEDTKHPAPSVRSVSPSSLDGLSLPPPRPPTPPKSSSTPELEFDGYPTPDDKEDYMHLAAAAFNLPVLRLKDLTKKPKMRSRPSNSNSNSRPSSRLDNYRDTSTADYDLPLTPSSPSYSHFANRGRPVTRPSPRTMTRPFRRSPHSWREPSPDVWAIEEETDDELHDSEMGDSHHTEQKYAGARNIESPSTASKGKKRVRFALPFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLL7</accession>
    <name>A0AAE0JLL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_141198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685275.1">
        <property type="nucleotide sequence ID" value="XM_062820938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLL7"/>
    <dbReference type="GeneID" id="87858092"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="341" mass="38151" checksum="5C4824281CE4AE31" modified="2024-05-29" version="1">MAPSPSRLTGAFTTLKQTLLALLDPWIFMSLSASYLPTTILSLLRQRRFLALLGGPLLSNEFQSAWFGHFWSWAGPQVRGNAEANVVPLLEGRVTKGQIVSKSEAHVPGVGGVVLEIGPGSGMWVSLFSDEKYLKDEDEQQGHDGEEEHEGLSASWATIASEQQQQKQATKKVVGSRQRITQVYGVEPNYGIHPLLQHNITQAGLSQTYTILPFGIEDIERYAPQIQPESLDCIVSILCLCSIPEPQKNIAILYRYLKPGGRWFVYEHVKCCSNKPGGWFMNAYQAFVNLFWPVCLGGCQLRRDTARYLREAGPWTDVDLAQPPKEQWHQTVPHIYGILTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMB8</accession>
    <name>A0AAE0JMB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp70 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_562038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685602.1">
        <property type="nucleotide sequence ID" value="XM_062830188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMB8"/>
    <dbReference type="GeneID" id="87867342"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3354224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="822" mass="89563" checksum="39F974B406B0246C" modified="2024-05-29" version="1">MSTNNSGNRGRRRQSHRLLTKSSKKPKPPSPLAALLTATFLLLIIVIFPLAISLLPLPVGASAYPTDDDYGSEEKGTPPPPVIAIDFGVTNSRVGVGGGFWRKGEGEVEVVVPNWVVFRDGAGGGSGKSGVWEGGGDEGVVGGEDEVYYEGVEVLVGEEAREWASLKGDGDPSAAAVFDVRRLLGRNFSDPEFQREIRHLPFKVTHDCCGSDVPVIEVEIEEDMSILAGEGGQDSSNTTAKRVLRYTPEQITAMIFRELKGIAEREIGEDVTQAVVTIPLAPGLHSYSTDSYTSFPTNYQAAQRFEEAYRTALRHAASLAGLEVIRFVKEPVAAAIAYGLDRDSDGEERTVLVYDLGGTSLDVTVVTVEEGVFEVLGSERVEGWYGGRKMDGNVARWVLKEVAARMGRGGGRGDRDGKVGGHMQSEDIMMLDPKLVRKVKKEVAESVKVALSGQEAVEIDVGELLTNLGGMERNLTMTRRDFEDVNHVLVYDTLSAVGRVLLAANVWWNEVDDVIVVGGSGKIPMVRRVVERYFRRENMTLREGNVDPAEAVVFGAAIQAMVLSGAEFEDCPLGAFDITPIAIGVETAGGVMRRSATFTTSTDNQTTLTLNIFQGNRPFTSSNHLLATIPIDLASFSIAPNLPRGAPRISFTFEIDSNGVLEVFLGDLKDDREPIATVQTSYAGGSSEDPAKWEKIESQIEEAAQFEIEDEETRARLNARRELAGMLNAVRRRLWIVDADDREDVREEAGAVRDALRAAEVWLKEHWDVETNTAEEFVKEKELLSGVVSPILDIVDWVFVDELPPRPPGEGGGSEVGSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMM7</accession>
    <name>A0AAE0JMM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_448314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685794.1">
        <property type="nucleotide sequence ID" value="XM_062825900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMM7"/>
    <dbReference type="GeneID" id="87863054"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000967">
        <property type="entry name" value="ABC multidrug transporter mdr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF631">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="23453" checksum="FC2837DDF01E076C" modified="2024-05-29" version="1">MCKTTMISLLERFYDPTSGTIFFDGVDYSQIHLGRYRSNIALVQQEPVLYQGSIRENIAMGVIDNGEATGVSDDEILEACRQANIDTFIASLPEGLATPCGSQGLQFSGGQRQRIAIARALVKKPRLLLLDEVTSALDTESERVVQAALDAAAKGEGERKRTTVAVAHRLSTIKGADRIFVFSYGRIAEAGTHEELLERRGMYYEMCLGQSLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMU8</accession>
    <name>A0AAE0JMU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_16754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685920.1">
        <property type="nucleotide sequence ID" value="XM_062821325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMU8"/>
    <dbReference type="GeneID" id="87858479"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000396">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="132"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3354542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="744" mass="81874" checksum="92747843A400BC5B" modified="2024-05-29" version="1">MAPDPEAGTAPQKGGWRLFGPSSTREQDNEETTGRKRLPKWNMGILNDRETIEVPGSVLLLAADHNEPLGLRNAPARTSHSSIPTAVIRPPEPPQDVLEKKKTSDGKIILDPQPEESANDPLNWPTWRRDSALLSLGLFCMVGGGMTPLLAAGFTDVANEFDVSVSSVSLTTGLYMMGMGLGSVVFSPTAILYGKRPVYLFGALLFVVTSVWCAVSKSFVSLVLGRIFQGIAVSPVECLPSATVAEIFFLHERAYRLGIYTLLLLGGKNLVPLVSAAVIERLGWRWTFWVVAIVVGFCGFLLFLFVPETFWDRVPHPRKKSSRPNFFRRMSSKQHIRRSDAAAVSVPPSARHSEEGPTPAPAPNHRRNVHVGFATETEQHHTEKDAEAAALQETSEKPDELQGSSVPMTARIVAEDSHVTRPGLVIQAPSSSDTSTKPHVSYMSDNIEKPKSPYFPDRPAGQDHTETDVESQSVASSRMVGGRVPYTAALRDQPAKSFVQQQLKPFHGRLNKDKWHKVAIRPLILFSYPAVLWSAIVYSCSVGWLIVISESVAVIYREGHYKFNALQTGLVYISPFVGGILGTAVAGKVSDVIVKAMARRNGGLYEPEFRLVMALPVAITTVIGLMGFGWSAQLGDQWIVPTVFFGVVSFGCSLGSTTSITFCVDSYRQYAGEALVTLNFSKNIFHGLVFSLFVTGWLTADGPKTVFIWIGIIQLILLFLTIPMYIYGKRARMWTVRKNFMEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMX6</accession>
    <name>A0AAE0JMX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_17522</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685944.1">
        <property type="nucleotide sequence ID" value="XM_062821430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMX6"/>
    <dbReference type="GeneID" id="87858584"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="651"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="801"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="609"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3354566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="916" mass="100818" checksum="26ABE67950182D98" modified="2024-05-29" version="1">MNYGKKDEDAETGLVKVDRTQVFQEARLFNNSPIQPRKCRILLTKIALLLYTGERFPTNEATTLFFGISKLFQNKDASLRQMVHLVIKELANSAEDIIMVTSTIMKDTGGSTDAIYRPNAIRALCRIIDATTVQSIERVMKTAIVDRNPSVSSAALVSSYHLLPVAKDVVKRWQNETSEAAANTKSTGGFSLGFGSSSRDLPINNSTMTQYHAIGLLYQMRMHDRMALVKMVQQFGAPGAVKNPAALVLLVRLAAHLADEDPHLRKPMMQLLDGWLRHKSEMVNFEAAKAICDMRDVTDAEVTQAVHVLQLFLTSPRAVTKFAALRILHNFASFKPAAVAVCNPDIELLISNSNRSIATFAITTLLKTGNEASVDRLMKQISGFMSEITDEFKITIVEAIRTLCLKFPSKQAGMLQFLSGILRDEGGYEFKRAVVESMFDLIKFVPESKEEALAHLCEFIEDCEFTKLAVRVLHLLGLEGPKTSQPTKYIRYIYNRVVLENSIVRAAAVTALAKFGVGQKDPEVKRSVEVLLTRCLDDVDDEVRDRAALNLKLMKEEDELANRFVKNDSMFSLPFFEHQLVTYVTSDDRSTFEAPFDISNIPVVTREQADAEDRTKKLTATTPSLKPPKVGPTKAAPTSAEAAASASAAAQKYAQELMQIPEMAEFGAVLKSSPVVELTEAETEYVVGVVKHIFKEHIVLQYEVKNTLPDTVLENVSVVATPSEEELEELFIIQAEKLETGVPGKVYVAFRKVSGEGSLPVSTFSNVLKFTSKEIDPSTGEPEETGYDDEYEVAEFDLAGSDYVIPVFASNFAHIWEQIGASGEEAEETLLLSSMKSIADATEQLAKTLSLQPLEGTDVPLNQTTHTLKLLGKTVSGGRVVANVRMAFSAKSGVTTKITVRSEEEGVAALVVASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN78</accession>
    <name>A0AAE0JN78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_535262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685748.1">
        <property type="nucleotide sequence ID" value="XM_062829025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN78"/>
    <dbReference type="GeneID" id="87866179"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="269" mass="30617" checksum="CDCEB5D1ED8031D3" modified="2024-05-29" version="1">MQSHDELAALFSRWSLEPVQQLAQVQVPNQEPKIVYVSAHYNHSAHTRPQDTQPSQPAPRGTSEPPALSEVEAVLRKHHVNTAGLSRGQLQLFKSVDDPQRYRLIDLWRNCPPTNRSDNPTLDWSMTSVNQEEILAKNRWEQQQQQQQQSVEQEVVMSLDGTPLTPIQAGDGRWIAADSHHDMEPYMALGYEEMARREYEESARRAFSESVERTKDACHPLAIATGGPIFNPAHSDPVYASSGVDWRQQEAMANQYGRLMAYRDDEEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNE9</accession>
    <name>A0AAE0JNE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_24321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686159.1">
        <property type="nucleotide sequence ID" value="XM_062822353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNE9"/>
    <dbReference type="GeneID" id="87859507"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="344" mass="39232" checksum="9D5164E26C0C777F" modified="2024-05-29" version="1">MAASGSIFQCLLRTSQQSLGKRAAQAQIIISRQTATAQAAAAPRFTTARLSSKATTPRRQFTTSSRRRQTQQPGDDPNFTSILDNPPELVRTGKRHGKGLIILAIIPITALFLGTWQVYRLKWKTDLIAKSEDRIIRPPLPLPPRVDPDAIADFDFRRVYAEGVYRHDQEMLIGPRMRDGEQGYMVVTPLERGDDPSTKVLVNRGWVSKKFADQRSRPDSVKQGEKVRVEGMLREPWKKNMFTPDNRPDIGEFYFPDVKQMAELTGSQPVWIEQTLVPDIITYYDYEARGIPIGRVAEVNLRNNHAQYIFTWYGLAAATSIMFWLVVKKPANQITKRVRMNKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNI7</accession>
    <name>A0AAE0JNI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_19135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685993.1">
        <property type="nucleotide sequence ID" value="XM_062821650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNI7"/>
    <dbReference type="GeneID" id="87858804"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="608" mass="68971" checksum="FBFA0561B3053197" modified="2024-05-29" version="1">MPPKRRANGAAPGQPAAQRQRLAPAAPAPAPGPPPPPPPPPPPAPGSRSFAELPDEIKTQIVIHSLSIFDNICAFRLFCSGWRICNWSRGEPQLDEILRKLRVDVYKPAPETLGVQLGEGEEQYFGELESWFAGHSRRKVQCPLFQEGAHGFDNRHCEQCGCVPFEKEVLLEGGAAWDMEWEGRFDPYARGRGGVWTGRLREGMAYRPNEPWNRLVKPAEETGIHAYLNSIRNTRYGRFLTREVKRERALRPDRLIVLQQRPWKWLGRFTERGLGRRVRSGLEGTITWGNEMVGFLPFIEGFTERFDDNGYLRVATGAPASTAAAAAIKARPFDQVKKHLSPEPPNQEPWFLYRHIRHLMITSNPCLNFTTGIDYERFGTIPPTDPPVGTVLANMTAVQGRVFFEHMVPLYVDYQALTNLETLYLDLRNIRKRSSGTTLFQMREVLQLARRLEGKNLRLLVIAGLRTHGAAWWGERELDIEEIEGMEEQNPGDWDDVNWLVEFRRALRPGGKLILVDAHSHHFPRNRYRPWINPRNDPGATPHAVNGLIGMGGFPAFLNNFIDNEANNNEVNDDEVDDDEGNDPMEEFSEEMTASEEATSEEASSEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNX7</accession>
    <name>A0AAE0JNX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_438330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686427.1">
        <property type="nucleotide sequence ID" value="XM_062825364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNX7"/>
    <dbReference type="GeneID" id="87862518"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3355049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="595" mass="66989" checksum="927AA670143C8423" modified="2024-05-29" version="1">MAGPSPHKPRRKAKRAGGNGPSNLPVIMEREALVRVPSFPLAAFLWPARSSVSQWELLPLILMVVGLFRWAAGLWGYSGFKKPPLFGDYEAQRHWMEITTHLPISQWYFHDLEWWGLDYPPLTAYHSWICGKIGSLIDPAWFALYDSRGSHDPTLKIFMRATVLVSEYLIYIPAAVIFVRRFSRLSDVPAWTSSVALVAILMQPATILIDHVHFQYNTVMLGFVLASMSSMLAGRNLWASFFFVLALGFKQMALYYAFSVFAYLLAVCVFPRINIPRFIGIALVTVVSFAILLLPVVAGTLSEASRGITAHPDGAYPPLPLFSDLAKHLNTEAFYYPVVEQLVQIIHRVFPFARGLFEDKVANFWCAMNVVIKLREYPAELLQKGALVATLAAIVPPNLILFLRPNKHLQPNKLLLPLAFATTAWGFFLFSYQVHEKSVLLPLMPMTLLLAGKQGLGNKRAWVGFANILGCWTMYPLLQRVDLRVPYTVLTLLWAYLLGLPPTSLNAYFQDGSSIWSQWATAFIHGFFYLTMAFWHVLDMFVVAPKDKPDLWVVANVGVGAVGFSLCYLWCLGSLVIESEILTSWTGKKMKTKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP94</accession>
    <name>A0AAE0JP94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_515192</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686318.1">
        <property type="nucleotide sequence ID" value="XM_062828654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP94"/>
    <dbReference type="GeneID" id="87865808"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF384">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042042002" description="chitinase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="39"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3354940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="419" mass="46096" checksum="F4FBC73E5E7FD7D5" modified="2024-05-29" version="1">MLSSILTYLIPLLSISTPAAAGASQSQSSAAGNTTVSSYRNAVYFTNWGIYGANFQPQQLPASQITHVLYSFADIKPDGQVILTLGRVSSDTYADLEKHYPGDSWSEPGENAYGCVKQMYLLKKKNRNMKFPPVAATEEGRRRFASSAVKLVQDWGFDGLDIDWEYPTNALEARNFVLLLRACRQALDDYARQYAPGYHFLITIAAPAGPQHYGVMDLPGMNPYIDSWHLMAYDYAGSWDSTTGHQANLLSNPKNLLSTKFNTDQAVRDFIRRGIPASKIVLGLPFYGRSFENTDGLGKPYNGIGAGTLEPGTWVYRDLPRPGAKEEYDNVAKASYSYDAASRELISYDNVLSALVKTKYIFLRGLGGAVFWEASGDKTGAKSLIGTLATQMKRLDQTKNLLSYPASRYANIRAGVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPF7</accession>
    <name>A0AAE0JPF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_451718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686727.1">
        <property type="nucleotide sequence ID" value="XM_062826068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPF7"/>
    <dbReference type="GeneID" id="87863222"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="5">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="291" mass="33630" checksum="F06CA94F16E3D65F" modified="2024-05-29" version="1">MFCLFLAPANSRLHRWFRRSFFTFVNNPPCSECLSPTNKIRNVAPTPEERAHSATWVELYSCVTCGAFERFPRYTEAWQLLRVKRGRAGDFANVFTMLCRALDIRARWVWCQEDYLWTEIYSEHQQRWVHVDSCEEAWDMPHMYYKNWGKKMSYVIAFSREGAVDVTRRYVGSPDALLPRKRCSEGVLKFIMEEITNLHRPKYAPDGETRLRLYREDVAEDVQLRSLWAATLEQSRRLKAAAAAATRGGRSSPDKNGANRMGSPATGDIKRPIPEDAPVPDVPSLWPTYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQJ5</accession>
    <name>A0AAE0JQJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_505494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686993.1">
        <property type="nucleotide sequence ID" value="XM_062827995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQJ5"/>
    <dbReference type="GeneID" id="87865149"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="262" mass="27459" checksum="C75A47F5FFA90AD6" modified="2024-05-29" version="1">MIIDGRTFVVSGGASGLGRACVRDIVKSGGNAAVLDMNEETGAALVKELGSSIRFFQCDVTDTESIASVVKSTVEWIKETKKPLGGIIPAAGVGSPGLMLDKSLNPLSLSSIDFVLSINLRGVLDLVRQFLPALASSPTYGPDGEHGVIIMVASSAAFDGQMGQVSYAASKGAVAAMTLPMARDLSRFGIRVVTIAPSMFDSAMTAMMSDKVRTGLKKAMEFPSRAGQPEEFASLARQAIENVMLNGVVIRLDGATRMPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQL5</accession>
    <name>A0AAE0JQL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_416597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687279.1">
        <property type="nucleotide sequence ID" value="XM_062824046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQL5"/>
    <dbReference type="GeneID" id="87861200"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF1">
        <property type="entry name" value="COLD TOLERANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="302" mass="33844" checksum="AA00DFFF2D64A891" modified="2024-05-29" version="1">MARLIVFDFDGTVTHQDTINVLAQFAISARSPSRSRQEASEKWKQIVDLYVADYAKHKESYVPRVDDRKTLAQELAYLESLRTVEVTSAERVVNAGFFAGLKKGQWEGFGREARRNGEGRNPDWDGDEGKAVIMRRGFSEFVQQAKERGEKLGIVSVNWSRAFVEGVIEPEDPDRSEFVKRVNEVKWPGGQLEGPEEMGGKVMMTARDKLEGFETILLDEADGESKKCGSVYFGDSVTDLECLLRADTGIVVVNEGEEEKSKLLGTLQRLGFEVPHVSESREGMKLAWARDFEEVLGSKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQQ6</accession>
    <name>A0AAE0JQQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_64747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687355.1">
        <property type="nucleotide sequence ID" value="XM_062831215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQQ6"/>
    <dbReference type="GeneID" id="87868369"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19690">
        <property type="entry name" value="bHLHzip_spESC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040106">
        <property type="entry name" value="Esc1_bHLHzip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF23">
        <property type="entry name" value="ZF-C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="479" mass="53013" checksum="9B5A0B3053AA7334" modified="2024-05-29" version="1">MMAQRPGSQKLPLGLAGVLNAPEDNRDSAYYSATDASSKHTSAASGVGVFTPNGSNFQPSPIDKTSPSPTNTSNLQPPQSHLPPVNSNMSVASMVSPTTPGSADPKRFDRPQSYESGPNGDLEAMSRRGSWDSRHSLNQGFNDMRLGNSPYASQNQSTTSIQSTLQQQRNPRSDLNGLTNHRISNGYQPSAERNPDGSRTRVAPTITGPATSQIARAAEPTKGQAWAFPEEEIQRVTSSNQSLIDSRRSSIAESLASSHFTMDSRLPSGQRRLDDNYPHRLSSVSADFANPTVHHHHHHSLQHRAISDLQNEEGGSHAGSQPYSRTPELRVSHKLAERKRRTEMKELFEQLRDLMPQERGSKASKWEILTKAISEHQRMSNHIQVLTSTLHNKDREIEHLRHELQRAQMETNSLRRSQPTPMGETYGFENRRSQQELPPLRTTLQAAAAAPAPGIDAMTGVQYEAPRVNGFRPPEPNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQX1</accession>
    <name>A0AAE0JQX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_414735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687506.1">
        <property type="nucleotide sequence ID" value="XM_062823934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQX1"/>
    <dbReference type="GeneID" id="87861088"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="702" mass="76274" checksum="B988230D7F613596" modified="2024-05-29" version="1">MASRRASLSPPERQGTMDPGAHELPGSDTEDHYSDAISSPKAPSSPIPRTRVERVDDKPAYGEVPGTKAYALREGDAKPDEFAIIPDPDSKLSTEEHDERRPSTPGGRPIPKTVVEETPDSTGAVTHPEIEARHRVDSPPDVLVKADGQKIENEKGGDNDTPIPPALKSPASIHSRDSSSDLDQPSSELPSLGPSLLEKEQGTSEEANDDAYDDVVQHNAKNADEAADENEFKEVEDVEVKTEQAKDGEAEDEKHEEEQSKDGDTTEEEGPKADEFEDASEEPENQDTKKEDSEDQFDEPEPSQEVENKVEPEDDKKDGASFDSFDHKEEKPVENDGFDDNGFAEAGDKAPDDDGFGDDDFGDDFAEPAQAGGDDFGDDFDDFEEGAETNNDADFGDFDDAGFDDDDFQEAEGFSAPAPAPEPQPQQPQSSLSFQIPDFTHLSLSEILSLTSPYLNALFPPSSDTDGDDSNSIPTLNVTSNGSADPIFQHPRSASLWSQLVAPPPLQPPDWIRSRIRRLFLVSLGVPVDLDEILPASKQKKLVLPSLDRRGSSAEAEGDDGGRAGRSRRPSAALRSGQAQSVDSRGNPSSRTPSKQPPVNKTVAAATGSANRSSSSARKGPPPEPVFDLVAAKQLCETTDEALSGMTVKELKEHVQKLYAMQEVAKEVLVYWQQRTDEKIGDREAFEGVIENLVKHARKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRI4</accession>
    <name>A0AAE0JRI4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_70123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687552.1">
        <property type="nucleotide sequence ID" value="XM_062831291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRI4"/>
    <dbReference type="GeneID" id="87868445"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3356175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="367" mass="40345" checksum="945FADD9D1CD22FB" modified="2024-05-29" version="1">MAAPEVHHLFHHPIADHSFSADRQTLAIARDTQVELYGRVGNAFKLKDELKGHDKLVTSVDIAPNTGRIVTCSQDRNALVWEPSPTGYKPTLVLLRISRAATFVRWSPSEAKFAVGSGDRVIAICYFEEENDWWVSKHLKKPIRSTITSVAWHPNSVLLAAGSTDAHARVFSAFIKGTDQRPEPSPWGERLPFNTVCGEFLNNSAGWVHAVAFSPSGDALAYAAHDSSITVVYPSAPEQPPKAVISINTQLLPFMSLFWNGETEIIAAGYDCEAFRFQGGEQGWQLAGTLEKAKAGRPGLGGEDREESALNMFKQMDLKGKVSNDDTKLKTVHQNTVTMLRPFEESGGRVTKFSSSGVDGRVVIWHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJA9</accession>
    <name>A0AAE0MJA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_76411</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676728.1">
        <property type="nucleotide sequence ID" value="XM_062831379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJA9"/>
    <dbReference type="GeneID" id="87868533"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="117"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="265"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="685"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3334562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="785" mass="87137" checksum="DB6718882ED76E8A" modified="2024-05-29" version="1">MTKPQGTGGKKKNQLTLAQLAAYDDILTDALVDHAYYWTTIPKNRTSYHPSRGIKEEEITKILQNHLIVDPDIATAQEKLLATDGLKRFCNTLKTPREQNDFKAHLRRYMSIYLPDCPFEVNATNRYTIVTYEASITARRFIKRNETIKYLAGIQVVITPEEELDMSLRKKDFSLIVSSRSKSTSLFMGPARFANHDCNANARLITRGQAGIEIIACRNIEVGEEITVTYSESYFGENNCDCLCATCESNLRNGWRPVDGEAVVQESIEDEQPTDSSTPYSFRRKRRYGSSALQASRTPSVTPDMRPRVMRKSQSQMMLGERTSTTDSGAQGQGADGQSRKRALEMGTPPFTPTKKQRTTQYPVVPIALSTAPSRGSSDNETSRSPLSFSTTNDNVTDATSQGSESPGPIILSPEPTPIKQAIGLLKQEEGVNEVAVQQVPEAFTPPSSQPTEEEPPVVRPTFERLAARDRMSIANLISGPSSPAPPIVVSVAEVTTHRPKPQTQQVQKTEQVTAISVAQTSTMEVVEAPVQKEAPVIKTESPVKAIVGQVEKITQVQTTTKSYTPSKPKAQTTAFPQHLIPVPAAPRGRVPRDYTLTPLLLSEPETAWIMCTHCASAFVQKNAYLTKSTCPRCERHSKLYGYMWPKTEKLGPNDKEERILDHRMINRFLTAEEEARARGRVYWRERMGSKGKQRSSAPPTEKKGTPSGEKKEQPVKKETGVGHGYVQERFAVRKKVKVQVRSTVPTPVIVTKKDEAAEAAALGLRRTGRARRVSAKLADCELDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJE0</accession>
    <name>A0AAE0MJE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_593015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676551.1">
        <property type="nucleotide sequence ID" value="XM_062831142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJE0"/>
    <dbReference type="GeneID" id="87868296"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="124" mass="13497" checksum="CD7C706097399429" modified="2024-05-29" version="1">MTKDMVEALVKGHKSKGVVFDDVIAGKGQGLIFLLHGNPGLGKTLTAESIADYLEKPLYSISGGEIGTRVREVEERLESIFSLAKRWNAVTLLDEADVLLCRRNSAEIDRNAIVGGKCRNSPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMU3</accession>
    <name>A0AAE0MMU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_477236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677376.1">
        <property type="nucleotide sequence ID" value="XM_062827418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMU3"/>
    <dbReference type="GeneID" id="87864572"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3337925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31146" checksum="B140D3CA7C278008" modified="2024-05-29" version="1">MDEKTLLPTTTPTTTNPPPIPSKPNNNHQNGRDKHALRRFLIAVCLMVMVWTLCGLDMGLDDNDALSEWSLEQMPLTPINTITIPTTDADVGGDAGHELVALEAHIMSKCPDARDCLRELVLPAMQRVYTKVNFTLSFIGTPTNGDDGVACKHGPEECLGNIIELCAQKLYPDPKSFLGFTMCLTKNYDEIPQRSLIEDCALEHAIDFDELNKCATQDDGALGIGLLRDSVKRSADAGVTKSCTVRLDNEIFCIRDGGQWSDCPHGSSVNDLVLAVEKLYGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN40</accession>
    <name>A0AAE0MN40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_435546</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677661.1">
        <property type="nucleotide sequence ID" value="XM_062825194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN40"/>
    <dbReference type="GeneID" id="87862348"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="976"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1021"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1066"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1141"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="14">
        <location>
            <begin position="273"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="15">
        <location>
            <begin position="858"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3338210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1225" mass="136235" checksum="2C1B27A8FC36F726" modified="2024-05-29" version="1">MRTRLAGTSEDGHLCPVEAPVPNVDFLLHQQLQQEQDVYANSTTNATTSPPIAPITALPRPSRPSQSSAAERTSPESPSVRQSPTKRDRNPGPSSPGAGPSNLEHQPPSQQSQNQQPQSFYARSRRSGNFNWKLSHSRNGSIEKPPPSFFSSSFSHSPSTPPLSLGAPANGAVHSKEMEKEEEQKFVGKRPRIRSPWAITFVTLLTSILGIGFLALCLNSSFTRHIDPKGCRMSYMRPGYAKFDDFDTEHTRFASKYSLYLYRELGIENDAKVKGVPVLFIPGNAGSYKQVRPIAAEAANYFHDVLQQDESAVKAGARSLDFFTVDFNEDITAFHGQTLLDQAEYLNEAIRYILSLYLDRTRSDRDPNLPDPTSVIVLGHSMGGVVARTMLIMPNYQANSINTIITMSAPHARPPVSFDSEIVKTYKDINDYWRHAYSQQWANNNPLWHVTLVSIAGGGLDTVVPSDYAGVESLVPDTHGFTVFTTSIPNFRKALVKAIFDVVDVNRAAQTKPRADRMRVFKKWFLTGMEEVAEKTVPSKDPSTLLTLEDNLNSVIRQGERLVLRSLGASGAVRAHLLPIPPSGSPEPKRFTLLTDQKLDISSENGRLEVLFCSVFPMQPGQAVAGFAAQINLAGESSASTRLACNNAASDVVTLPASVRSSQYPFSKDGEPPRTPFSYLQYDVEDIAEHQYVAVIEKANTPTPGFVIAEFSDVSQSHRTRHISLRRLLAFGMKFRLPSSRPMVSELKVPTMQSSLLAYNLEISEQNCGEQQELFAPLVRQYLTEPYESKFFVNARKAAVSIHGVAPYVPPPLKSRSTEDGLSFQFWTDPTCASNINIKMSIDVRGSLGKLYMRYRTVFAAFPLLVVTLVLRKQFRIYDTTGVFVSFSESLDLCLRQSIPLVLAFLTFLSLFIWNSSSSATANIWIWANVTSGAIDFHQNDLLIGTQDPFFWFLIPVIGLICVGICTVFNYMTLTLVHILSIAVSLLSFRPGWIRNEERRKALPLPAFYPTSPRRRMVTTAILLVLVSTLIPYQFAYLVCCLVQLTTTVRAQRIASDLKSAANSNFYNYVHSILLLMLWILPINLPILVVWIHNLAVHWLTPFSSHHNVLSIMPFIILVETLTTGKMVPRVNSRFKHFTSVLLFGIALYAAIYGVSFAYMLHYLVNLVAAWLAIVHSTSDPWSVLSGIKHISCTLFDAGNTSNVGGVNGTTNTVLAEDRKMRKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNT7</accession>
    <name>A0AAE0MNT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_477233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677375.1">
        <property type="nucleotide sequence ID" value="XM_062827417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNT7"/>
    <dbReference type="GeneID" id="87864571"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000016">
        <property type="entry name" value="Scavenger mRNA decapping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3337924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="340" mass="39176" checksum="E94EFD332D47314F" modified="2024-05-29" version="1">MSDVKANAEALVPKFKFERQLNQDQAGRRTTLLGTIDSSPALLILERAPFPTSTDYLSAAPLTLRTIKNLGANDVYNWYMASSGAIPTNKEEDDFSDLKINLIYPCTPKHIAKYSRQAVRYVSETPSIYRDHVRPYMQAQRESGRLNWVFNIIESLSEVEDVIYRTPYGQDPNGEGFLLLQDLNWDRKTLDALHLLGLVERRDLWSLRDLKKKHVPFLRHMKKKFVEITTQVYPTIEEDQLKLYVHYQPTYYHFHIHIVHVQLEAGATQAVGKAVGLDSIIETLEAMEGDGEAGMERLTMCYTLGEESDLWKEVFGPLKKKEKEQQQQQEQKQVGEELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP26</accession>
    <name>A0AAE0MP26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_432581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678244.1">
        <property type="nucleotide sequence ID" value="XM_062825013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP26"/>
    <dbReference type="GeneID" id="87862167"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042250882" evidence="2">
        <location>
            <begin position="21"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="968" mass="107572" checksum="FC9297DDC735B55A" modified="2024-05-29" version="1">MKLVFTLAASALLATVPITASPIIPNTFTNTAVGKKDTVIVSAATVSNIIHPTTTIVGLRPEVSAAANESDHTTSDSEDGGKAEEEKAKNGAKRSLSPPSASASGLDGDYDFLPVHSLPRRSSHTAEFWKSHLPSHLPPTSHNRRGPQSHTGDYWNHHPPASSPNRRAPGPQELSQDDMNKAMFDFHSVSDVAQRRSNSRFDAFMLLPSYHCPNKGSLVTCKDYNYYDCPEDTLWCRHWDKNQKNANGRFGVWVGDTEKPIKKTKRGLDVDVQRRSPGHPGIKCTKTHEFPFCNDIRNITIETCSCASYQKNATTGFHYLKIMGPAEKDDSDAPKHKRDLSDGVDDSPDAVDSSSYHLARDGKKRDSIEDINAFDSGSYGSYLPADVDDHNSMPIARRADTSNFLDYHCSNSDWVVRCGRNRNKPKECRCYGWRWDGKKAHLDDMDEAIKNKKRDVSAGEDEADLVPLSELSGDLLTRKLASTYYCTDPRAKIMCEQSKSTECWCYTDETEQTGTGESVTTMVKGDKPVQDSGSNSDNEDSDGSEDKEKEEDEKPADKRDVTSDSDSQATNSDFESDFETKFRRANPPLQFDVAVTLPAEVVKALGPRKRDFLPGNDTEDGKKRDVEVKMEVEEHLPEASVLERDANGNDHDHELFARGNNGFGTRKVECKETGMIAGFCLINGYCYCLQCRRWPDNCNFAQRDGKRGLTDFLDNLLKARTFGSEVNTNPKPQNMPNYVMHIYSQVIANNKKIQLTCRNSVGGLCFEEGCFCFHCEIALNNCRVRKIGGGRSKRRDDNGVEQLGDDHDELLTIEGGDVVHYDEKSLINEKRGGGSGLHRTSSFGHPLTVGRRSPIPIPNNQAVLEKRNKGFECENALGAFCFDKDQCYCLRCKKFPNESCSLDQRKFFTNSKKKRDSGATVSSEEDTKPEAIDVAAPPTITPHTVVNGTKGGAGRTKMKPVDKLKARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP85</accession>
    <name>A0AAE0MP85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_510513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679307.1">
        <property type="nucleotide sequence ID" value="XM_062828406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP85"/>
    <dbReference type="GeneID" id="87865560"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="337"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="967" mass="105837" checksum="779A6D176973D6B7" modified="2024-05-29" version="1">MTRPEIIRADTIDLQGRGAHSTQAYHSSTYNHGPLAPHQAETLREVAAEAAEEAIHSPRVSWSGGEAGGLHHYAHDHETGVGQAHDNLQNQLYNGGGNNMASRSHQDALAIAQNGGHSDIDDGDLDGDNEIDDDDDGMDKISSSPSIEDGGSSFTLPLLPPHSCDGLTLPRGSPESSLASSPVSDPRSSSPYLNRPDYLSPGRATQAIGESSPSTLRRHHHHEGKYGNFDLTGGPTPGAEAYAFLEEEMRNSRWLLSEYSSRLNGSKFSAVASTENTSGAAAIRTSVKGSGSESDSPRLTVPYESDTDDDGDFSRVHDADFLESGWGGECLQDTEDIDFEFVYALHTFVATVEGQANATKGDTMVLLDDSNSYWWLVRVVKDSSIGYLPAEHIETPTERLARLNKHRNIDLSATMLGDQADKPRNAIMSAMKRTKRKTVQFAAPTYVDYSDIDYSTEEEDLDAEYFGQQQQAQKTQQSNVQQIEPDTDPEDETAKVEPLKPRPLQTKTGEDSAGRSGIRNSEEIFESKPSEGPKKSSDGNVRDSFFKDDVETKKITLTPNLLRDDSATRTSSDSVQSKQRPSLDKLEKDSPTSKDDKKRKEKENSKKPSAIRSFFSRKDKRKGQEDDETHGKSPQDADGHEREHEEDERNILSSPESAPAPQRNPSKLQKSQPTNAKPIAGILKDTSMDASNYMSAGRINNVSNTPPSTMRLVEPEPNDMTEGSPQEQRGNREQSPESSRKQESVGQSRDAGAQQLTQPQPRSEMDFDSDEDDNTGPAQELPATAQEPQRQQERSAPASRNPFATAQPAASSVAPSHQQHAERLSESPVHVSPVQADHRTSPTPPLMADSSSQEDRSSERLTPSPELVEHEDDGADDKDIAPPSPVSASTPTWNDASLRAFFDSGSEIRDMLVVVYDKSDIEPVGPDHPIAGSLFKEQNAKLAEITTQLDNMLGDWLARKQRLRGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPA8</accession>
    <name>A0AAE0MPA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_323178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677885.1">
        <property type="nucleotide sequence ID" value="XM_062823437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPA8"/>
    <dbReference type="GeneID" id="87860591"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="98" mass="10587" checksum="A841094DC3380DD6" modified="2024-05-29" version="1">MGWSSACPFHPIPGSRGGTPPPWGPYCGGVWLIKLTVAQPNMPARPIQLDYCLCSISSSSPFLVIGLLLAIRLEANNSVDHFQPDPSSSVLFFFNSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPN3</accession>
    <name>A0AAE0MPN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_429897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679727.1">
        <property type="nucleotide sequence ID" value="XM_062824851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPN3"/>
    <dbReference type="GeneID" id="87862005"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="805" mass="86844" checksum="68067FDBCD10CBAE" modified="2024-05-29" version="1">MSRVRRFWKIFHCHICGGDVKAQLYCPSCGHPFCRNCQREVVAEENVTKVVTASQALDPFQSVDHSPNTVEPPMPTEKPIRKIRKPDPEPDERPAVTSSAAAEPALVSSPEAYALAQAGNASQDPAGSQEVEHRKRSSNVQNETRLTSPPSETKDRPSLHQHAFAPATEEFSQAITKCTEGTPTLNISSSVRNAQNTHIVSSEETRGTLEAFSPSPVHPALPPPLFLPPRTMVIDVRKTPDTSRWISPPKPVAAVSPSPPLPAQPGVARQFSAVKRQARKLANGPSSRASEESPGADAETVKSTSGSSVNATNQYYMPKVKVSSPPLWLKFPSTRTGGNAQRTKRAEPPANNTRTGSVASTATTITGDSGRTGASVGSHAIKETSAPETVTNPYFPQLDQQEQQAVKQGEESRHGVHERQGEHGGYQHSGDFHEQTTLHGHARKVSRKVSEDLKARILSLPVSEQASKPSKGNRHPLQADSRSGNKTGLATVINRISDMQSDHSTYSGRSTPSTIRSGVTTPKLRPGRTLTPSSGKGAKRAGGDRRHSQNRTPTPTTARSSGSHSQQWLQQQQRSSLHSARQPTGQRAKRPQSPPAVEDIHRQSYSDATGLSSLPSRSSVTSYQTRDAIIDRTERSNHRTTTRRESETAPLLNSNVTSTPTAKMIGNRPPPKKAPIASSADIHDHRSGLRRADRERTSSDDETPPNEGDYGHTTSPPPQEIVRQAEGSSEEETGCHHDPGTGIHGLTIVLHLKGQEDLVISTDLTREASGADGASSVTMSLSPIVPLSPQSPNSGHRVASPFRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPQ5</accession>
    <name>A0AAE0MPQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family group 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_444760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679758.1">
        <property type="nucleotide sequence ID" value="XM_062825701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPQ5"/>
    <dbReference type="GeneID" id="87862855"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="191"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="309" mass="35121" checksum="4FD358340BDD3914" modified="2024-05-29" version="1">MPGWKGRGRLMQADEGGRLRQVDEGGRLMQAGYGRKMKEAAQVAVLPIPVEPRHGRYTRSATAKSIKHAISTYELQGGAANMFINDDGLQLISEEDRQERIEFYADHSIGWVARPRHGENGFQRRGKFKKAPNMNFALMISCKVEEKLSQIQRSPEWSQHDEAQAYERALQEVLAEDGRAWTDGNIRMGDYILLIDSDTRVPADCLLDTVSEMEQSPDVGIMQVVHTYFENGITFFTNLIYSAIRYTVSNGDVAPFVGYNVILCWSAIQQVSYEDEDGYEKFWSESHVSEDFDMALRLQCNDYIIRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ12</accession>
    <name>A0AAE0MQ12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_268918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679671.1">
        <property type="nucleotide sequence ID" value="XM_062822723.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859877"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="12">
        <location>
            <begin position="1508"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3340729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1786" mass="196442" checksum="B450D9C44D2DF796" modified="2024-05-29" version="1">MSSLASQLAQIATNSRSTLNTKVLKAAHSKSLIFEPRVAATQTYPEIYSICLEGFEELCNLDSRFAKFAQSLWSEQSQEADRTQMSAAENAALDKHVEAFLHLCGSRLRLMPAIKAIEWLIRRFRIHEFNTAALIATFLPYHTIPAFVTLLSILPANIPKEYRFLDPYIRSLTAPPRAAIVQQATNRPELLTAISQYTLDSCKYQMEYPGLISFWGGVMVEATNGLLDKYRSGRRSIQIENDNALMQQLGPVLSDAMVMKSSPGLQIASYMVVTILAAKGGLADNALTAFMDQLVHGWTPETMRPGLVTLCIISQHRSAKQLSARVTKALLKVPELASVMNEIGKDHRVDKLANGLALALVDRLHKKGDVRSLPVVNSLLLGNVLREKQIKVVYKSLLVAAHRINDQVDQDGAIRKELGTILVSLSQAGGEVGDIVRATIEEVDFDIDALELTLGASIRPKLAVEDAPEAAAEDNTPKVDKEAELAQNFEKLSKLKPQTASCFAEEPLDLLEELYSLFLSVAADETNLYKFDEAPVLSRPQAPTKLFYASFYMRLWCGSLPTLAKVAALDRVKNLLKDEEFAKLDFQAVVPYAIVALSDPAKKVRRAAAELVTVLGSFYETKPSKARRVWGSEGLYAKTAAVSWLDFDATKSLLHSVLIPSLEESLLHEDHILAALTNALESSKSKDGDKKHLSHATRLAIFKFLSSHVVGTPLIAVKLRLLQPLNQIKSISGTSRTDLLLPLLQWWARLSEAEAQQLLAREAVDEASVNNAFVDVVVANNEAGLKLIFELINNSNVVARNGLVQSLFGRIQKIWSSMKAETQFSTARALLTLSQAVHPTASEPDVVATEATDVLHKVELTTDILLDFLESLYDDIKKATEKPATKRRRVGSSEKSVDTQSPADVSASLNKATFVLELVQESKPEEHPELLPSLFTTLSELQHLRTVVGSELGYLQSLVLSSLLAMIPAYKDSKELTIDPAAGHGDILASCIQRSSSPTVINAALLLVASLARTAPDVVLHSVMPIFTFMGSSVLKQADDYSAHVVNQTVKEVIPPLIETFRKSRRNLVASTAELLTSFVVAYEHIPSHRKQDLFITLIENLGPEDFLFAVLAMFVDKYGATDNMLAFTAQIIGSFSVEIQLQTLIKHLDLISDMFKPKPVLSAALLAKVDSNSSQDVHELAKKQLTLLPKLLANRRLRREISGLAEKDDMESVKIRELYAQLLEGVLTLAGTVKAKKTLHDRCGEALSNLLNLLSIAEFIKSVEALLDRPNVTLRQKVLRALEHRVDSESTNNPKSREALLAFLPQLTAVIRESDDMSYKHTAVNCVDKIAEKYGKKDLDAVAAAAATIAGDSCLGQPSQELRVMALLCLASLVDVLQDAIVPVLPIAIPKALGCLEESIKAEKPDGALHNAAYAFMAALAQHIPYMISGAYLDRLLACSNASAAAGLDEECRANRADCLQFVAKLIEGKVLFTALEKNWVNAAASGYSALEEYLHVLGTALDKHPKSSIAKNTALFTGIFLNAFDLRRSGVLSSTQELEKIELLINETSLKMIYKLNDAAFRPMFSHLMEWSTTGLPKSDLAGKAQRQVSTYGFLQHFFENLKSIVTSYASYIIDSAVKVLSTPLSGDDVLKTLRSRVLRTLTKCFEHDQDGFWQAPAHFNAVAPVLVEQFGHAASADNCTEDLVLTVVELAAAADSKEHHKEINSALLKHLRSEQAAVRLAVIKCEQALTARLGEEWLQSLPEMLPFISELQDDDDEVVERENRKWIVAIEETLGEDLDNMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ97</accession>
    <name>A0AAE0MQ97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED10</name>
        <name evidence="11" type="ORF">B0H65DRAFT_472920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ97"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3340592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="247" mass="26324" checksum="B876E8C6A5D497E9" modified="2024-05-29" version="1">MAPVTATHQEAQESVKNVIQDLLNLMVQVSQYDTNPSSSNNNTPTNNSRASGGGGHPSSRDVIAQSLQTLDASLLSVYRTATLLPSSPSSPSGGGLNNPSSNGQQGTTELERAEAAQFASTFNSTHNPYAPHLHQPGPQNPGIPIPLITYVENGRNPDVYTREFIELVRRSNQLMRGKMHAFRDFRDILAGEMEAALPELREDVRRVVEATGGPGPAEGSEERAREGVVGSLSVGEGQQGQGQQGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRF8</accession>
    <name>A0AAE0MRF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_523653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681171.1">
        <property type="nucleotide sequence ID" value="XM_062828802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRF8"/>
    <dbReference type="GeneID" id="87865956"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="295" mass="33741" checksum="8890057A812D3C8B" modified="2024-05-29" version="1">MDLSTIEKTADDLHGELQFMLDAMTAHRDWIASNRATGQENSRRIEGIEIMVQTGISTASRLKSEIIKQRNLVEKQISDLAKDQQSVAKQQEALTAKEQDLNVRERAVKGNENMKVLKDSLKASDKTLTKAKKQYEKEIAELAQKNASLGGQAKASEEELANKNRELDTRISELANAKMELAEVKQQLLSGKELVLTKEKVETEKQHLKREKQQFEMEKEHLQREKQQFETKKECLGRELEQLRLENEEIKAAQEDLEDRQKALQDQRNELASKLLDAELDGRLRGRKRPALLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRJ1</accession>
    <name>A0AAE0MRJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_428167</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680884.1">
        <property type="nucleotide sequence ID" value="XM_062824741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRJ1"/>
    <dbReference type="GeneID" id="87861895"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="459"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3343091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="608" mass="64645" checksum="C90DF07C82195C03" modified="2024-05-29" version="1">MTTTTSPRSKISTSSALTHPHRTIFKSFALWKLFLLAIAVGSTLVNDRAYDTSADLLLIGNDEPLSVNDGNGVAELLRNFGKRLVTRFTSWDAIYFVSAAKRGYVYEQEWAFGTGLVVCMKGVLRALQTLGLPMPLTTSPTALAEATTALLLSNASHLLASLVLYHLTLLLPLSGSSSSPYQTKKLALLTSLLYIFSPAGLFLSAPYAESSCALFSFLGWWFYARSCLSDPDGVFASFSGGKDATGSSKEKRPGRSGLTLKGDINLLLAGLSFGLATLFRSNGILNGLPFAWEVLSILSGLVTTSGGGRGRVPLLKTLRRLIALGLGGIFVAAGSIAPQTVAWLRYCPSGSLWLFNKFLSPEVVAVSGTSGGSGSARGYGGSGVGAGVSAGAGGGLEELVAQEAREWCGAVVPSIYTFVQKHYWNVGFLRYWTLPNIPLFLLAAPMLAILVKSALDQLSQRSPPSPATATVTVNSDTKSKTPPKTLASGSNSSSASDTPSSGSVKSDEVVTQQLAPESTTTATQQRMQILIRSAAAEQVLLVVLAVSTYHVQIITRISSGYPLWYWWLAQQLIDGHKQKKKLGKGIVVFMVMYAAIQGVLFTSFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRU3</accession>
    <name>A0AAE0MRU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_442088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681184.1">
        <property type="nucleotide sequence ID" value="XM_062825560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRU3"/>
    <dbReference type="GeneID" id="87862714"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="110" mass="12678" checksum="1E90BC27A49DA773" modified="2024-05-29" version="1">MSSGLDVEQSTRTGIRSARVTADEATNLFPTQTAQPPPCHLLRRHRQPRPPRNLIDIENKYYNAKQTKTSDPEEALQEFLSIPPLEQEKGDWGFKALKQAIKLEFKLERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS25</accession>
    <name>A0AAE0MS25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_509963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680765.1">
        <property type="nucleotide sequence ID" value="XM_062828355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS25"/>
    <dbReference type="GeneID" id="87865509"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3342972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="98" mass="10861" checksum="51EA5BB3AD747A7E" modified="2024-05-29" version="1">MSANYERERQNNARLDELASKVSALRGVTIDIYDQARNHEVIDQTTDTFSSMGSQLKGSATRLGRMAASGNKVAILKLSGILIGSFLVIYYLYRLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT18</accession>
    <name>A0AAE0MT18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_441021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682459.1">
        <property type="nucleotide sequence ID" value="XM_062825497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT18"/>
    <dbReference type="GeneID" id="87862651"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="673"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
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            <begin position="76"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <end position="165"/>
        </location>
    </feature>
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            <end position="182"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
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            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <begin position="252"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="287"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
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            <begin position="345"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="411"/>
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        </location>
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        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367053"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF02940"/>
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        <source>
            <dbReference type="EMBL" id="KAK3347377.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="975" mass="107285" checksum="66D0CF849AC7401B" modified="2024-05-29" version="1">MDLRNVLNDSSSGPVAPRAAASTPDRPPPQQQQQQPPHPQYSQHPPQHPQPPQRQQSYQHHQQQHHPGYPQPPTTPGQAPHPQQHQQSYIDYNHHQTRPSPGRHISQDSGYGTQRMPSGAFASPPPFSGPPATGPSPYANRPPPPPPLQQVPAHDPRSPSLASGPGPSPYRHTPTSSISAQSGGYPFPPSAQHTPTSPVQRPYNQYPPSSTAAYPSREGYPPTPGGPVGVTGPQPPPPPGPPGPPGPGAGGAPYNYLQGPPVGVPQTPPISTAGGGTRQYLQRSHSTHSGSTPTPTSAHSQGPPGHSHSHSHPQVYGPPFGRGSPGGQIVDPQQRQSSQPATPVAGPGPLTASTTGGPGTGARPLPQATVSQAQAQAQNLNHYGQPPSPYQQRLPPSATTHHHLNLNSPRSSQHYHQQISSPHSHPAPQQPPPPPPPPPQSLPRQHSAQSIYDARERERELRERSISISPKTRVPSLPSSAGRPATATSVVSIPESEPPRLNNHTAAPMARYRDEVRDGDHGHNAAAKRKLDDRELRPDELERRDVRPPPFDNRARPSHTPNKSVKRRAYDSPPPWAQQATRGSTLKEPNFVLYKPVHAPGHGPVQINGHSRHPSPEEKRSVPRAHEPVPRAHEIRPNERSATPSAQGPPPEAQAKWGPLGPWEPTLTGDVPQDTMAKVMADFLFHYIVSNENMGEIHSRGIQFEIEAKFGELIDRNTNQRIELGVLSPTILKEDDYVYPFRSIMTEAQHRSYNEYLNHQVVISKNPKSNIGRERPRVPISYEHKHEIDRFYAIPPQIRDRHLPVTVANLLASKGRDAKVRVSYKENKDGSREQIAKIVKARLKDLSIHFPEHRLDCRISINLEMPWEGPIEELEAYATGANKGQSPDRRKNRLSYGHCSYQFDLTQVVENVNLNVRLTEQPQGRDEKKHELEIELDPKAVLDQGRRAREGQPNQYFDLVEGFLNNIRIMAKMCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT58</accession>
    <name>A0AAE0MT58_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823711.1"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    <sequence length="50" mass="5040" checksum="7A3184D4DAAF8A23" modified="2024-05-29" version="1" fragment="single">GRDHDSTLAGDDLLGGAIVEASERPGSEAGLQLRSKGRHSVGQIANAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT84</accession>
    <name>A0AAE0MT84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_398536</name>
    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682654.1">
        <property type="nucleotide sequence ID" value="XM_062823775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT84"/>
    <dbReference type="GeneID" id="87860929"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="33"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="495" mass="55700" checksum="9CDC4AF94BA1720D" modified="2024-05-29" version="1" fragment="single">IRLLQLLPSENENAAIHCQLFCTALDAKGTRPYEALSYVWGSEDKPCSISINGYDLAVGKNLYAALLHLRDHSIERTIWIDAICINQKDLEERGHQVQSMAKIYAKASRVIVWLGEEAAGSNQALEEIRIVAERDQTLEEIRIAAELSTRRSDNKAEILTLLQRPWFQRIWVLQEVAAARHILIKCGSAEIDGFAFCSGLNVLNLFNELPADLRARILSVTYLIRGAIFRPKYATSQLDNFSLNIRPLGNLIEMYHTREATDRRDKVYALLGMSSDNPTAAGLFADYKIQWAQLFNKLIHFLLSELVSVVGLSDDKEIACIEGKGCILGEVSSVKRNATWEDGQDVAITWSNAPSYICVKEAWGSCWTLPTTVKSVQKGDVICLLQGASSPTILRPYNDHWAVIMIAVFPAGDSQITTGDIKWSELLQSITVFPHNFLLIWDWDINPDRQQDKNNHDYFASIPVPKHSKTGLESCLNVATRIRNVRLALQEVKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTS0</accession>
    <name>A0AAE0MTS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_99984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684123.1">
        <property type="nucleotide sequence ID" value="XM_062831677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTS0"/>
    <dbReference type="GeneID" id="87868831"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042071173" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="12617" checksum="3928C8F3E2AA516D" modified="2024-05-29" version="1">MAAPLIQFLLLTIIICIADSIASAIATTTATTTASIQGSSSGELGGGGLDGGGLDGGGLGWFWMDLGGRRAKLGEGAGLANRRPDFNIIGSQSSQSGVGIGSWRLSSRQRFCLSLSIVNFRANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTT9</accession>
    <name>A0AAE0MTT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_508167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683314.1">
        <property type="nucleotide sequence ID" value="XM_062828205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTT9"/>
    <dbReference type="GeneID" id="87865359"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3348232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="620" mass="67993" checksum="A20CBB37B4F9699D" modified="2024-05-29" version="1">MSFNWRRPFTRRQGDQNLANSESHYYRSNGSFDGDGGTVSDGSLQYTVEKGGNDSPTAYQEATGAPVEVNSPLGYSVGPLSIIMLNIGKMIGTGVYSTPSNILRGTGSVGLSMVFWALGFLTSVANLSVYLEYAAYFPNRSGSEVVYLEQAYPRPRWLFPTAFAFQSVALSFSSSNAIVLAQYLFRINGHSPTAWELKGVAVAGYTIAALFVSFHTRLSYLLANGIGIIKVLTLIFVSITGLVVLGGHVSTSRIPDPRVNFRDAFSGQATPYGVTNALYKIIFSYAGFENAFNVVNEVRSPVKQIRRNGFVALLIVAVLYILANVAYFAAVPKEELVKSQQIAASLFFTKVFGSSGAVRGLNFLIALSSFGNLIAVLIGSSRLIRECGRQGVLPFPRFWASTRPFGTPLGPYFVKWALTTLMILAPPAGDAFNFITDLQVLPSAFFQLIMGIGLYVIRYRRSRLNLPRPEFKAWDLVVVFNILVQLYLVVMPWYPPAGGAYAGDVSFWYGTYVVTGIGILIACAIYYYLWISVIPKLRGYRIRQEVLRLEDGAQSHKLVKVPVAKLAEWDATHDAVGRPLNDSTVRSDRGSAGSNGGSDEKKPTSADEVPVRRNKQDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUB9</accession>
    <name>A0AAE0MUB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_508021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683150.1">
        <property type="nucleotide sequence ID" value="XM_062828196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUB9"/>
    <dbReference type="GeneID" id="87865350"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="141" mass="15335" checksum="EDAC05A7BC7F1D08" modified="2024-05-29" version="1">MSGQQGQPSRGVLSLIPPHLARLRIHTRHTTSLSVNRSRHRHNFCGPTPTDLNSFLIPSGRPSATYTPSTTWPRETPHQQTHVCPNPIFPPFAPESQCTSTEPVVPQPQQRSSAAVANNIAPHTRTAPIVAFPTTSSYSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUH8</accession>
    <name>A0AAE0MUH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_97981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684049.1">
        <property type="nucleotide sequence ID" value="XM_062831645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUH8"/>
    <dbReference type="GeneID" id="87868799"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="258" mass="28110" checksum="7B3DD8185FF9C54B" modified="2024-05-29" version="1">MNSPRAAMRILRRVGAPATRRRFSQFTGSGSGAPLRPMGNIPMPYITEVTAGGWRTSDIFSKLLQERIVCLNGAIDDTTSAAIVAQLLWLESDNPDKPITMYINSPGGEVSSGLAIYDTMTYIKSPVSTVCVGAAASMAAVLLIGGEPGKRYVLPHSTVMVHQPLGGTRGQASDILIYANQIQRIREQINKIVQSHINKSFGYEKYDLAAISDMMERDKYLTAEEAVELGVVDQILDRRVKDEAEKKAKDGETPAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUK0</accession>
    <name>A0AAE0MUK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arsenite translocating ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_125560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684857.1">
        <property type="nucleotide sequence ID" value="XM_062820734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUK0"/>
    <dbReference type="GeneID" id="87857888"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="339" mass="37484" checksum="F4DA3BFC090C300C" modified="2024-05-29" version="1">MSTAVINADDDHLEPTLQSILDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARLIDGFNNLSAMEIDPNGSIQDLLAGQGENEGAGDMGGVGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPSVLEKALAKVSQLSSQYGPLLNGFLGSNGTLPNGQNLNEMMEKLETLRATISEVNTQFKDERLTTFVCVCIPEFLSLYETERMIQELASYGIDTHSIVVNQLLFPKPGSDCEQCTARRKMQKKYLDQIEELYDEFNVVKMPLLVEEVRGKERLEKFSEMLVKPFVPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV02</accession>
    <name>A0AAE0MV02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_90015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683795.1">
        <property type="nucleotide sequence ID" value="XM_062831539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV02"/>
    <dbReference type="GeneID" id="87868693"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="67"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3350500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="399" mass="43470" checksum="26FC460C20C82488" modified="2024-05-29" version="1">MAREEPLQRESGAPTPNSLDLGLVGSMAGNVILPSKSPVIHVDEKGLEEVRQALQACTDLGLAGDAINKASFPLPTLHVVLDEARRQVHEGQGFAIIRGIGLSNSAQDNTNMFLGLASYIGDVRGAQDKQGSMLTHVTASKTWTVPPELRHGIHTNTGLAWHNDMGTDMIALHIRSLAEEGGNTFVAASWTIYRELMTSYPQVLELLCEPCWPIQVSGNPPRHIVAPLVQVHNNRVYLSVDPGRLGLHPVTAKAGLGSSIPSLTTSHLQALETLSELATRHRLMLDTKPGDMLFINNWALIHARDSYKDPKDGPGRHLVRLWLRDSEFGWDVPESMRVPWEAAFGSNGDGYPTGITHRKYPLVPSHDYKPPKYTAGSAAFVLDDSDDVNGEGTEPSKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVR8</accession>
    <name>A0AAE0MVR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_6500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685641.1">
        <property type="nucleotide sequence ID" value="XM_062831221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVR8"/>
    <dbReference type="GeneID" id="87868375"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="238" mass="26921" checksum="32B467BDB464F035" modified="2024-05-29" version="1">MPDIQNEESKSNPADIKSEECRDDLPALPALPAPPNMSTPYLFLGQVIDANDDKDKDNMNDSEWNDSLSPKQRLRFCLKKLLECNVPEALSITAQHKTILRPILLKTYWVKGEITGFRLRNGELTGFKFAKGELTSSKLVWEERPRHYTAVGRYIFTPKENGEKTCTECMNPEGYGPFAECVAGGRAGVHQGACLNCYYKGEEEGCSLRIDMFPSHLILPATHIHDTVTKNMIYYPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVY5</accession>
    <name>A0AAE0MVY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_4324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685594.1">
        <property type="nucleotide sequence ID" value="XM_062825002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVY5"/>
    <dbReference type="GeneID" id="87862156"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="50"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="9">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="216" mass="24141" checksum="EE47E5E99D4AAFBB" modified="2024-05-29" version="1">MPMYGDLGNKLVQHAKRTQNLSHLPPYQTELVRAVAREIRDLDKDVASLLEPFQGSFDPSTEQATACTLLVNHLSMRRNKRCLLAYHRTRTDKLEELVWNGADILDLAGQATGVPKGVTVGNEGSGTTSSLSPQEEDYFRQFGDLLALYKGQWTDVDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGAINLTKNSQFYVRQGDVERLIAQGYLQKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW31</accession>
    <name>A0AAE0MW31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_130143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684965.1">
        <property type="nucleotide sequence ID" value="XM_062820791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW31"/>
    <dbReference type="GeneID" id="87857945"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000082">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="117"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3351670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="428" mass="46358" checksum="4CD9E95CCEB824F0" modified="2024-05-29" version="1">MPSRADITYFGAGPAALPTDVLETAAQALLDYQGTGLGIAEHSHRSGLAANIIDEAKADLATYLDFSPEQYETLFMQGGGTGEFAAVMYNLVGAWVSRQHAAVQKELGEGAADEAQVLAALRQRVESGLKVDYIVTGSWSLKAYQEAQRLLGPEYVNLVCDARTVNDGKFGKIPDESTWKLSKDAAYVYFCDNETVDGVEFPNFPKILEPKEDGTGPIVVADMSSNILSRRIPVNNYSLLFFGAQKNLGCTGIAVAILKKTFLPPTISQPCPALLRKLALPIPPIVLQYEIIAKNNSLYNTLSIFDVYIAGQVLKKLLATFPNGVDGQQAVAEKKAELIYAALEAHPETYKIVPDKSARSKMNICFRVIKGGNVDEAEKAFLKESTALNLTGLKGHRSVGGIRASNYNSIPLEGAEKLAKFIDEFAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW89</accession>
    <name>A0AAE0MW89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_449510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686121.1">
        <property type="nucleotide sequence ID" value="XM_062825957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW89"/>
    <dbReference type="GeneID" id="87863111"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="256" mass="28586" checksum="141348EB0BF8FA94" modified="2024-05-29" version="1">MSTMQACHGHNEACCNIPPVVTSGYKPKGSYSEYDGLKTYVTGPDDATKGIVVIYDIFGYFDQTIQGADILATSDDTKYKVFMPDWFKGEPCPIEWYPPDNDEKKKNLGAFFGKNPPQGVAEKLPAFVKTLSAKHANIKSWGIIGYCWGGKVVSLITSNAETNPFSVAAECHPAMVDPEEAKGIKVPLIMLASKEEPDDKVKEFEQNLSVPKHVETFKDQIHGWMAARADLKDERVKSEYIRGYKTVLEFFGKNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWG1</accession>
    <name>A0AAE0MWG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_25239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686179.1">
        <property type="nucleotide sequence ID" value="XM_062822487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWG1"/>
    <dbReference type="GeneID" id="87859641"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="24366" checksum="5C9AD28EEEE81842" modified="2024-05-29" version="1">MEFHHQPASNIVSETEPVSPVHLAQASPFCLHPREADLPSWGYTVPPPDQRHDRILPSLPTSEYLPRLLSAYVVDALLWEWLPFHTMQTASFEPRNLEAVEILLVLLFLFEFGFLPIKLSQQVRQPPTCPLISERWHGGQKARSRCRLGFQNPLRSLKPNSRRYGGSQRSSVVSSNGSFKTFHWPLSLCLVCILTAPFVSEYYIDCIARPLSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWR1</accession>
    <name>A0AAE0MWR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_545015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687152.1">
        <property type="nucleotide sequence ID" value="XM_062829342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWR1"/>
    <dbReference type="GeneID" id="87866496"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="527"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="762" mass="86668" checksum="FFB20DEA463785F7" modified="2024-05-29" version="1">MATLIDNIHRRAHRVHSRFYPHHGHRHAAKDSYMTLTIRNLPLGTTENDVFEHIRRQRPDSDPIVNPLTKETNQRTLCAVVTIRQETEEKCKALRDRLNLTRIYPKHPAGDVRDSAVMVSDEFLGVTTIAEHDDPQFDMYFVHGLGGHAFKSWSTDKGAPHMWPRDFLPDDVKARPLNPMKWEGRKLAGRFATVGYRASAMFASAATATIDKISQNFLNHLRADRTEGSKRPMYFACHSLGGLVVCQALIHALSEESHRLERFQDCQSTFFNGEECLVKGIFFFGTPFEGSRLARYASRIVRFLHGNDTLIDSLSIQSEDLNTIVARFDQMRNNPRTRIPIVIAYEMQPMFGMRFVTDPDSAMSSFDCQTIGIEGDHRTMIKMEHNQDRSYRDVAEFIIRMIQRTLSGSSSIPPSPAAEFEREIFRELPFRQSIARDESPPPYQGQNSGRPSTESSASNGTSATRPSPHSQPVGLGISNSNPEENNSPGRSRSNIVPVRLNDIMMPLNRVTGGREDNREFALLSKFDVVFLLDDTGSMIEATEAAPSSNGNCETKERSKWDEMIESLRYIVDIVTHYDRDGVDVHFFCNEDKDEFGIQDGQRVLDLLTNEVSPDEIGGGTFIAERLWTILTAYIDRFENYRRRMGERAPPPEKPKMLNLIVITDGAADDKDAVEEVIVDAARRLDELRALPNQVGIQFLQIGKDEAASRWLKKLDDDLNEKHRIRDMVDTRPWDRVDEIDKSLQERLTDILLGGIDRARDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX35</accession>
    <name>A0AAE0MX35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_19854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686030.1">
        <property type="nucleotide sequence ID" value="XM_062821747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX35"/>
    <dbReference type="GeneID" id="87858901"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3354652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="237" mass="26176" checksum="A14BE0583614C696" modified="2024-05-29" version="1">MISRQPYAPTPHSYVPNTALSATINLDEEVKLADTRAERDLQDSLAEIFSIIVTLDELEKAFLKDAIPEADYTEICERSLKQYKSLVADETVAKAFVGLEEFKAKWDLEVPRATERIRVGMPSTAVNASSGPAPATVAASGGTSGTLILEATQDFITFLDALRLGLLAKDQLHPLLTDVIQSVNKVTDRDFDNRGKIVQWLITLNQMKATEELSEEQARELELDINSAYQGFKSTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXT7</accession>
    <name>A0AAE0MXT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_415121</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687633.1">
        <property type="nucleotide sequence ID" value="XM_062823964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXT7"/>
    <dbReference type="GeneID" id="87861118"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 20" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="41"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="204"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="491"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="596"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="703"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1081"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3356256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1233" mass="138496" checksum="CD54DFFC4EE52FD7" modified="2024-05-29" version="1">MAPQQQSTNQDWDVKFDQVRREKLFRDPPTDRTAYPALQAAVDPHIESFNALFRDDGKPSLLDHALAEIGTKTFLDGDERADPAGKNKLTIRYKSIELQKSQVPPTNRWAKNREIFPAECRERHVSYRGKLSATFEYRINDGEPHEFVRELGQMPIMVKSNKCHLQNNSPAQLVARKEESEELGGYFVVNGIEKLIRMLLVNRRNFPLAIVRPSFQNRGAAYTPYGIIMRSVRPDETSQTNVLHYLSDGNVTFRFSWRKNEFLIPVMMIMKALVETNDREIFEGLVGPPQSKGVANTFLTDRVELLLRTYKKYGLYSKTQTRAYLGQKFRVVLGVPDNMSDYEVGTEFLRKIVLVHLGCQDVTEQQDADKFNMLLFMCRKLYALVAGDCAVDNPDAVQNQEILLGGFLYGQIIKERLEELLTVSFRGSLRDYLRRNPTVSFQSDTFLKDFPIAIFRRANENIGQSLEYFLSTGNLVSPSGLDLQQVSGFTVVAEKLNFLRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHLAHKCKIMTESVDASTIPRLAFELGVVNISSAATSESVVVMLDGRIVGWCTPEECKSIAETLRYWKVNGENGVPLQLEIGYVPPSNGGSYPGLYMSSQPARMVRPVKYLPLQKEDFVGPQEQPYMSIACTEQEVIPGDSTHVEFDPTNILSILANMTPFSDFNQSPRNMYQCQMGKQTMGTPATALAHRTDNKMYRLQTGQTPIVRAPLHNTYGFDNFPNGMNAVVAVISYTGYDMDDAMILNKSAHERGFGHGSIYKTKKVSLKDDSRTRSAKSIVKMFGFAPNSTIRESTRDVLDNDGLPRVGRLLREGDVICAWHTVSADYNGQLVNRDGVTHYERYKDSEDAFVEEVRVIGADNGTEPLQTVSIKLRIPRSPVIGDKFSSRHGQKGVLSQKWPATDMPFSETGIQPDVIINPHAFPSRMTIGMFVESLAGKSGALHGLAQDSTPFKFDEQNTAGDYFGHQLQKAGYNYHGNEPLYSGITGEEFQADIYIGVVYYQRLRHMVNDKYQVRTTGPVVPTTGQPIKGRKKGGGIRVGEMERDALLAHGTSFLLQDRLLNCSDYSKSWMCRQCGSFLSTQPTVSPFIGKRKAVSTVRCRNCAVRLDDMEDVDLMQMDGEIWEDGSGTQWIGGENTTVVAVPGALKYLDVELAAMGIKLKYKVDKKDEIRRGQLVPKKAGELMLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MY60</accession>
    <name>A0AAE0MY60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_517161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687215.1">
        <property type="nucleotide sequence ID" value="XM_062828674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MY60"/>
    <dbReference type="GeneID" id="87865828"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="4">
        <location>
            <begin position="269"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3355837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J0G3_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_553616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676853.1">
        <property type="nucleotide sequence ID" value="XM_062829979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0G3"/>
    <dbReference type="GeneID" id="87867133"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="141" mass="16381" checksum="0DF97E3C9A6ACCA7" modified="2024-05-29" version="1">MAKADYNHDDSWLSSRQKIRLWSSTGVNWDDYKVIKRGGNMVCMRRDEIPVPGTACFEAHCQPPSPTQMRGVYIEKLRLMAPQNPLVRSHEAKQARIDCLQEEILFLRVEISQRQKLVNGKAKELRHLAPDYTFLFYAFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0G5</accession>
    <name>A0AAE0J0G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_390918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676812.1">
        <property type="nucleotide sequence ID" value="XM_062823742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0G5"/>
    <dbReference type="GeneID" id="87860896"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="125" mass="13892" checksum="539C6C3DB19C4B66" modified="2024-05-29" version="1" fragment="single">FFAQVIIGCLAQIFGPVQQLSVNSKFYSAKLPPRLQTPALPHVTVQCPVYKEGLAGVIAPIVKSIKHAISTYELQGGAANMFINDDGLQLISEEDRQERIEFYADHSIGWVVRPRHGENGFQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0L7</accession>
    <name>A0AAE0J0L7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_481622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676511.1">
        <property type="nucleotide sequence ID" value="XM_062827635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0L7"/>
    <dbReference type="GeneID" id="87864789"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="104" mass="11572" checksum="8C468A7AB8EB166A" modified="2024-05-29" version="1">MARKAAVIKVSFFFLLDSRYSTCRICPKREAISCQLMHLITRAFGSPAFLFAGLDRSLCRISNRLSGIAALTPLTFWKKMVRADMDLATGVNTNSGQHLKTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0W9</accession>
    <name>A0AAE0J0W9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_334763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677020.1">
        <property type="nucleotide sequence ID" value="XM_062823552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0W9"/>
    <dbReference type="GeneID" id="87860706"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="103914" checksum="C9C49C07DC8B5980" modified="2024-05-29" version="1">MTTGKLNNEGHDAQHLDVSRSALIQIITGVITATKVSEGISEHARSIISNTGLTIQPKRDTFTIREWLDNVVLQTKDNSPESQASWQLVHLALGVSMLRHKARQGQPVDGADLEFVWGLVRDAVTDPVLAPLLPGASRSAQGFLSVPLCSLIKDNRIDELWRLHVWLPDGHRGNRDFAIHSHQPFAQSWILAGEGRDHQYDVTDPEAKGALGTPYAQYRIAWSGTGKSHGTAYVPHQSYSIVENTGKIVHIKQVETALHTRDMSYTVGAGVLHRTKVPADALHATLFYFDSSRGFIQDAPVLGPPDGESYKQYRDVGSQPPSSLASMVEAVRSFERLMEEGQQYTRSGNLEMALRNFSSALALCESGAAASSAIPKGDRYKQFVFTKLGGTYRRFGKYEQAKDFLEQAMAMTASSELRIEASGELGVIYRHMDLLDDAKRAFRVQYDTAKEFQAEQFTCRSIGNLGMVNYQLSQQRQDESLLELATNQLLERVERSRQIKDTIDSQDLDAATREQWLKDAITWETIGLSRLSLCYAARGDAKKAVRAAFEALTLVRTFEDVNVVAMGRFFYGRALLLDGQRDAALQQFNSHDGGCTPALALCKEPSDEHRQYLRELIDAGADMSVTDGHGYSALDYATFAGDAKAQDMVLEGLRRQAGGVDDDSNTSSLLHKESKLRKGYRELFQERLRPVLLAGGGDPDSSISELRRVYAESLAEDADKRAMFDVLRFVPYSDFLAFGKFPRSSDNLAQEFKASKTPESGNGSKTWADYLIFFSYRWINKEPNAKTPDDGNHSQYRRMIAATEEFLKMHPHVKRDRLGVWVDFVCVDQDDPMSGVSALPMIIAQCNAVISLSDDQLHERAWCSVESMMIQTLKKAYNVHVWYEQVLDDNCILRDGPVDLSIVMADKRLTFETDRPKVLFLERQCKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0X5</accession>
    <name>A0AAE0J0X5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_561475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677069.1">
        <property type="nucleotide sequence ID" value="XM_062830174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0X5"/>
    <dbReference type="GeneID" id="87867328"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="701" mass="74400" checksum="0E081CFEF2ABD204" modified="2024-05-29" version="1">MTSSSFPHRPPGADEVGPGRSVDDHALNPAVPTTTDYQTITKPPQTANPNPDTKLKMPETAATRKAQVVPLLGSHDEPEPEASSSSSAASSSRPSDENQHNTSIDSLAPLTPGLIPANQHHNSSFVEEDDLTTGKYALRSWLTVLGAWLAIFSSFGLLTVLSICQNYVSAGDNEEQVASISEGTLAWVFSLYFVVSLGLGMYVGPLSDRFGARWMVLSGTVFLGVGMVVLACRSETWAILLAFGILSGLTSTFLFIPSLVTIHQFFSRSPRYYTFATSLATTAGPTAGIVFPYATRNLFHEVNWPWTIRTLGLICFFLAVIANFLIRSPPFVPTSPASSSLGKKGKKSRTPSPPPGSSASSASSSASDNSTTPMVVGGPSAIITPSASARPALVGKLASAPHPSLTPFFFSSPSSYTLLFLSLLLIHLSIYTTTTYLSATSLFSQGYSHSFTFRTSTLVVNISSIGGRLLAGLLASGSPFWSSSSASTKPPSKAGGMLKGLGAFNTTILFSLLATLSLLAVLLPPILHPGRVGMSPSRFTAFAVLFGLSSGAVLGLEPVLVSLVCGTNNNNSKTQFGQYFGTLYTIISLASIAGIPIGSHLINACRGMYWGLVVFVGVSFGVGMLGLLLVRRSVVNQTGDNKKGKKSAAAAAVAGDDERIDDGLRGFEWKKLSLWKERKTWSELTERVGRSWGEVWGLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1P7</accession>
    <name>A0AAE0J1P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_561664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676717.1">
        <property type="nucleotide sequence ID" value="XM_062830181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1P7"/>
    <dbReference type="GeneID" id="87867335"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="164" mass="18761" checksum="3B0B4796F7DEBD5F" modified="2024-05-29" version="1">MCTAIMILHTICTHHTRRREPCFFASGHWTEKLTIPNAPKNIVATLKTPGACNWKLDIVDRIEFGYCSLCLGTVEVNVWLKYEERDFEGAQEMEDVAGSGSVTSQEWLYKVGAQKKFKRQFGFKGARVNRPVTCPSPRKDKKKIQFGFCDRCVDRRKAVEKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1Q2</accession>
    <name>A0AAE0J1Q2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_341049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677236.1">
        <property type="nucleotide sequence ID" value="XM_062823645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1Q2"/>
    <dbReference type="GeneID" id="87860799"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF215">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="5">
        <location>
            <begin position="75"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3335070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="624" mass="67067" checksum="97683EA4D9C033C6" modified="2024-05-29" version="1">MPSALKMASKTSATTTTTSTGQPLSDIPLSTGRTDATAPSGTPSTTSPSEASTISSTSSPSGASSSLPTHNYRPRVAILGAGISGLSASLSLRRAGWSVTIFERSLFANETGAAITLPPNASLCLSRWGFDFEKAEPVPNWSIRFARADTLEVVKTEEYKGFGEDMGWRSWGVHRADLHKGLRELVIRDGVKGAISNGERETEGEVDGGHGTKGMVDGGPVDIRLGREVVGVDCEAGVIEFKDGSKSGRWDLVVIADGAHSKLLPYILSPSMSPKDAKPQDLSPQEKEPQVQPNPQTLARPTGRSIYRFLLPLLPPSPLLANPHLRPHFLPYSQGGPLPGFLSWHDPIRDVLWVSYPCRGGRVLNNAIVHDTQPGEAGESPGWSTAVGREQVLRVVEGFHEGVKGLVEMAYAGGAGDGDGDDEEEGDGVEKAVVVDEGCRGEERGTLTGEKGIKVHHLFKRPALNSFVRGRAVVIGDAAHVMMPTHAAGGAIAIESAATMEVLFRGFPPSETSSQLEEFVKGRLKLFDQLRIPRCNLTMLASNAGPKWLNVEGVEEEVRRYYKGPLPHKDALPWTREFREVLFCYDAFEAAKEAVRKEEAAAAGFSSESKGSEVKVSEVEAENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7U1</accession>
    <name>A0AAE0J7U1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_434950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677934.1">
        <property type="nucleotide sequence ID" value="XM_062825168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7U1"/>
    <dbReference type="GeneID" id="87862322"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="474" mass="53483" checksum="DE5B0220D97312B2" modified="2024-05-29" version="1">MDTLPAELLRLIFDNCDPPSVRALRLTSGRLADVGYDYLLPPSFRAVEWKDDVQRLHSIAHHDRLNRSINSITFNFSKVDEYSARHASFFQHWLQEPEERSILLQDAWIKYYELEGKSRDLPPFHTRSAMVEESFKRLPNLKDLEITYTKCPYDIEVFKDVFLVRNCRKRDPTFRAQTCKNMNAIISAVRHVSLNSLTIDQLPLEIFRLPDDRRHWFDCCASSFSSLSKLDLTIDPPANLMPQSRFKAINGLGHVLQLSPNLTHLSLSFHTYHAPMQKFGFSFRALLQDFTFTKLTSLKLEGVSCSEEDLRSFLLRHAKTLERLRLGGRGLAKPYELSIGGVHLHEGSFRSLFTSLQGKLPKLQRLHLEGDLEAGDIRTGARERETFKFHASVDEDWEDMNGADDFGRRRVVQAGKTMDSSALERYLIHGGPFPKLVVPGAASAASSEGSPSPELGPVSGGPGMAATPATAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7U7</accession>
    <name>A0AAE0J7U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Galactose oxidase/kelch, beta-propeller</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_323804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677910.1">
        <property type="nucleotide sequence ID" value="XM_062823443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7U7"/>
    <dbReference type="GeneID" id="87860597"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042128114" description="Galactose oxidase/kelch, beta-propeller" evidence="5">
        <location>
            <begin position="21"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="661"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="779"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="671"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3338459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="97275" checksum="DA0C09FE9678B0F7" modified="2024-05-29" version="1">MVLKNLAVLAVAPYLVSVQAQSFWDKEQVNTTLCYWEELRAAIIRDTIYLDGGRSWWIPGLADGSPGAIEDDENPYGRIFTLNLGTPFSEKDNITDKFTIISKAPADGGVNNIDPNYYDGALLANDAQWFAYGGLYLKSDAFDTEPPGNQVLGYRKYQYGLEKGEFTTGFVKASLKNVSRYIAYGAAASAPSENKAWYFSGMQSPSRGPVLGVSSGDDDQATEVAKTLITLDMTEQLEETWKNDTLPSKIPGRAGAELVWVPVGSKGILVALGGLVFPQWANSTKFSGNDTASKAESPEFMSTIDIYDVAAGEWYRQPTVGGPGQLGRGCAVVSPAQDFSSFNIYYYGGQPGLTPFEDFSDDVWVLSLPSFTWTKVASGTADRGRAGHKCFMPYPDQMLVIGGYRSYPQSGPPQCLDQFIRVLNLTTGTWLTSYDPAKYSITYGVPESVQKKIGGSAIGGATARAPSGGWATADLGKVFETKYLTKIATYYPYASEAPVNNTNPGAPPSDKNDKKKGGGVPSWLPPVLGVVLGLMFLTIIAVLILLWRRRRLLKAGTSVAETEDTNGYRIMSWMRGQQQHATEKAPTVTTSDEISTVPNSPSPMRDIDSTGSAMPPPSIAEAMDTQITPPPAPVELMDTSPRAELHDTGLSHIDVLNRHSSFGRNNGAGNGSLSNPSYYTGGTHQIDHASNFSRSTGVASSLPPHMQGVDGAPTNFRPDSKLMGSVPSGAPSSNRDIPSPMVSPTTTATRGFALSDVSNVSERDKAHLRQISDATVSSMTSGQTYNNNGQHPSNVNSNHRFSNGPSPTSVPEEHVINHQGGLQAPDHIPIPQSATSAMGGTLPLGSPQPVSPPTSGLAEGSEDYLSFRPQPPPTAGLGPGAAGGAGATSSPRRSMFTESREDMNGTGPGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7V2</accession>
    <name>A0AAE0J7V2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_327400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678027.1">
        <property type="nucleotide sequence ID" value="XM_062823482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7V2"/>
    <dbReference type="GeneID" id="87860636"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3338576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="384" mass="43326" checksum="88B56CB62C2A2744" modified="2024-05-29" version="1">MTLSHNQPDQPPMASLIDIGEYVMPDIQHPDESDGMCSIKTTPISGSEYGGDDQKEPLMPKESLPTTKASVSEAHAGTQSNLVPSNKVIIAERPFDARNSLELSFSYGDILHVIGRKNDQWYKAFNPAQPDVRGLVPVAYFRDVDFWDTKLWGTRLGEIVFVGSILSSFLFGVFGPFIPFGGLFFLDWRSSVEPTTPCTSSSSCANKVQIPLCGPTKPYQPYHLLPAYNQTAYGILDCNHNATHAELWLSFFDKSTAATLVHFHDRGGMPNEIDCRPWKRPMLRYTEASGLNEFTPEEWAIQYLFLKEDRSVADFVILPSLGIDTPGPISCHNDETSLRRRSHQYIVQMEVVRQQIARKRQLEIKELEDKKKKSETTRKPSGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8C1</accession>
    <name>A0AAE0J8C1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_432195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678248.1">
        <property type="nucleotide sequence ID" value="XM_062824986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8C1"/>
    <dbReference type="GeneID" id="87862140"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="379" mass="42025" checksum="F5B26FB577BBDC73" modified="2024-05-29" version="1">MVTSPKSPKSPVSQSPNSNQASSPPAPVVSGSGPTPLGAEEQNAAGLLPASHWTQQPLAEEDPADDGASTIGSFTSSTASLSSKIFEYRTIHGRTYHGDVGNAEAWEPNDQRHVEAMEIFHHAMLVQLDGKLYLSPLDKKKVHRVLDIATGSGMWAIDFADEFPNAEVIGTDVSPIQPSWVPPNVKFEIDDCNQEWTWAENSFDFIHMRMLIGVVDGDWSALFRNAFRCCKPGGYAESCVCDITFVSDDGSVKEGSAMDQWGKVFTEGGKKLGRTFSVYEEDLQRKGMEAAGFVDVEFVDIQCPIGVWHPEKKPAERGLWYKMAVEADLEGYINYILQVVMGWTPEETKAFATHVKQEWNNPEIHGYFMIRVVYGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8F3</accession>
    <name>A0AAE0J8F3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_446050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677602.1">
        <property type="nucleotide sequence ID" value="XM_062825783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8F3"/>
    <dbReference type="GeneID" id="87862937"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000217">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000610">
        <property type="entry name" value="Pentatricopeptide repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001206">
        <property type="entry name" value="Pentatricopeptide repeat protein (AFU_orthologue AFUA_5G10660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF24">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="8">
        <location>
            <begin position="516"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="885"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="920"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="956"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3338151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1188" mass="130309" checksum="203B8AF1F42BFF3F" modified="2024-05-29" version="1">MNLQLRIHQSFPNVIRSGFSKSFTHGYAQSFVAATHHNVLNPPNRPSFALRSSTGLGGRLSKLGLQDAFRTSSNLNAGGSVEVRHDNKTTVLPSNAGLLDAYYEQLQKSQAAHEAGEEQDQEWVQFQFPKLIEWKPTAASVLAQGDANTLALAADEVAKLDDGVSRVPPEAEAALAHINARIEEEIEVRKQLEAVEEELESLRATSPALAEKLEEEIRSRSRTPASHLRTPASVAQTATPPLGAQSISYAVHLTKLSEAARYAEIPAVFEGMLLANIQPTATAYNALLMAAIHLPSEKSEIVSKALDVYADMLKRKVSPDSDTYNILVGLLASRSLEVFASKSLLQDKRLRFGGMDEPGKFMFASHELEYAILCEDDRLDLALKLFQSSMKSDKAVYSSETYHQLISACAQSGRVSDMLHLFEHLEANRVTPFAATFPAMITAFANAGDLISAVECYNEYRNLAIANDNGEPTLQDRLDAQVYAAVINAYVVSDKIEGAMKFYKKIVEEYGVSSADIKDALISGGFVKGFLERGIYEEALRWAQSVEQDARARVMSQVAIAAADHGYKNIAVTAFSTISSHDEAANPAIALLAMSVRQADVASAARYWAALSHPEVKATSSFIEPAAMFAIALIGSGQVVEGLTEAEHMFHRIRESAATETKSQVTDEIEEAAEFIHEFMTARGVTDPRSLPSPAPYASQSFSASPYPATPTASTFEDIFDPYAHSTDFKGSALISEDLESNGRKGPKLNDALTRFRNVRRAGRHPRYITYAKLISAAARDGKMDLCFDILAMARTDVPLLPQYAVVRYGWSSILDAMVGACLTLGDRAGAEQYHQELLAMGSTPSANTFGLYITTLKESTKTFDEASEAVKIFHRAKIEGVEPSSFLYNALIGKLGKARRIDDCLFYFNEMRKMGIKPTSVTYGTIVNALCRVSDEKFAEELFDEMEAMPNYKARPAPYNSMMQFFLTTKRDKTKVLEYFERMKAKGISPTSHTFKLLVDTHATLDPVDMTAAESVLDMIRASGQHPEPVHYASLIHARGCVLHDMEGARKVFDSVINDVSIAPSPCLFQALFEAMVANHHVADTEPMLAEMRARRIEMTPYIANTLIHGWAADKNIAKAKEIYAAVGREKREPSTYEAMTRAFLAVEERESAKGVVSEMLGRGYPSAVVNKVLELLGGGNAEEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8K3</accession>
    <name>A0AAE0J8K3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_445238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678355.1">
        <property type="nucleotide sequence ID" value="XM_062825730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8K3"/>
    <dbReference type="GeneID" id="87862884"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="117" mass="12667" checksum="F6BFFB1C8DB98907" modified="2024-05-29" version="1">MARKSGVSVVDGAVHACAAAAHGGTAFRRNVTAENAQHRPGGAKYLVPYTQSTEHRARRPNITSNTIVSDCSAARIFKVVGEAMAWSFLERQGQSSAAKCFNFVMVDEARFLYECLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8M1</accession>
    <name>A0AAE0J8M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_288936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678419.1">
        <property type="nucleotide sequence ID" value="XM_062822984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8M1"/>
    <dbReference type="GeneID" id="87860138"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="250" mass="28333" checksum="743F1B6FB61826B1" modified="2024-05-29" version="1">MADCCPDSKLSTAANIIGLLTFTLSALNLLIVRVLRNESKIIKQLRKGGWKNSLNALEQKIRYIRLFNPAFAGFGRDNMHPDHASGIPRVPDVGAPGERSDLEEKQPEERFTEILKDVQRCYDQGKVTINETEAIQHLLAEQISLAGYARATRRLILRWDVENFYEASVSVCRQLYNWRESREAVDKLEDNYQELNSIVAHVDSLILVMQGIKLLQLQRTIDRQASTIVDTVNTINTRSPTEPTPSAPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8U1</accession>
    <name>A0AAE0J8U1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_530351</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678101.1">
        <property type="nucleotide sequence ID" value="XM_062828925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8U1"/>
    <dbReference type="GeneID" id="87866079"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="224" mass="25247" checksum="8D2F0BDAF429FA88" modified="2024-05-29" version="1">MADWDTDAALDGHLRDQNGTAEKKPKNEHRWIWFVTGPTACGKTTVAKALAKNLNFTYVEGDNYHPKANVEKMSRGEPLTDADRAGWLQALAEHETAAPPTSKSSPHLVITCSALKRHYRDILRLGSEHAGDLRVRFIFLSAPEKVLRERAQKRKGHFAGENLVHSQFNILEMPDPKKEEEEGGEKDVLVVDVDGRGVEEVEREVLERVRGEMGREEGDFLRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8X7</accession>
    <name>A0AAE0J8X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_321579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677842.1">
        <property type="nucleotide sequence ID" value="XM_062823414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8X7"/>
    <dbReference type="GeneID" id="87860568"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="465" mass="51434" checksum="A5B601B6E28B8D5C" modified="2024-05-29" version="1">MADEIAKEYDVIVLGTGLTECILSGVLSVKGKKVLHIDRNDHYGGEAASVNLETLFKKYGNYAAGTEPWKQYGRPNDWNIDLVPKFLMSSGELTNILVSTDVTRYLEFKQVAGSYVQQGAASKATIAKVPSDAAEALRSPLMGIFEKRRMKSFIEWVGEFDPKDPATHKGLNMSTCTMKEVFDKFSLETGTKDFVGHAMALYLNDNYLDTPGAAPETIERIRLYGQSVARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTSVDELVYENGKAVGIKATMAGVEPEMKFETRAKMILGDPSYFPDKVKVVGHVLRAICILKHPLASTNDADSCQLIIPQSQVGRKNDIYIACVSSAHNVCPKGYWIAIVSTIAETTANHHLELAPGIERLGKIEEQFMGPPIPLYEPLEDGRNDNIFISKSYDATSHFETSTEDVKDIYRRCAGEELVVEGLREGIQMSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J928</accession>
    <name>A0AAE0J928_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_531210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678593.1">
        <property type="nucleotide sequence ID" value="XM_062828938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J928"/>
    <dbReference type="GeneID" id="87866092"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="429"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="535"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3339233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="653" mass="72340" checksum="758D2C0A7B1208B2" modified="2024-05-29" version="1">MASSDQNRDAFPDDVSIDDDTSVISTRGLEAFGRKVTTTASHLIGPITDPTSHPHYQTAMTEIHKQLQKPTLQRSVFAIARTTPTDLVRSKLSSKEIESRALAYVPDELLRNIPASSNSYSLFQGFQASFPDFTDDGKKHKRRVSRGRKMLDESPVQPGSPHAVQRLKKDKASMMHQLEMLGVRKNMASSEIREIDNKIANLHGMRKIILDRLANLEKEEAVLEHDIMDVESRLDEAQELADEEELLAMATPNKSEEDLSRTEEGFMSQSIYEKLPAANTAPGKKKPRNHRKKSLPILHEHFEPGTMIRSMRAHQDNITALDFDAPFGLMVSAAVDDSVRVWDLNAGRCIGTLEGHTASVRTLQVEDNFLATGSMDATIKLWDLSKAHYDPQGSQEVDEEDEDLAFVNPDDHAVDPPAGSMADCPLFTLEAHLDEITALHFRGDVLVSGSADKTLRQWDLTKGRCVQTLDVMWAAAQATAMGSSDGPWRQTSRSADGSADFVGALQVFESALACGTADGMVRLWDLRSGQVHRSLVGHTGPVTCLQFDDVHLVTGSLDRSIRIWDLRTGSIFDAYAYDHPITSMMFDTRRIVCAAGEDVVKVYDKVEGRHWDCGAGITEAEKAKSPAIVERVRIRDGYMVEGRQDGVVGVWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J931</accession>
    <name>A0AAE0J931_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_475826</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678595.1">
        <property type="nucleotide sequence ID" value="XM_062827330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J931"/>
    <dbReference type="GeneID" id="87864484"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000566">
        <property type="entry name" value="Serine/threonine-protein kinase rio2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="67"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="346"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="355"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3339235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="425" mass="48009" checksum="7BE250A7B606D1E3" modified="2024-05-29" version="1">MFLDTRVLRHLTAEDWKVLAAVEMGSKNHELVPTPLIERMSRLKGGVSGVHRSIATLAKSGLIGRMKEAKYDGYRLTYGGLDYLALHTHSSKDVVYSVGSRVGVGKESDIMIVADKTGKQKILKIHRLGRISFRTVKSNRDYLRNKQGGSWMYLSRLAAMKEYAFMQALQEEGFPVPEPINQSRHTIVMSLVESLPLRQVSSVPDPASLYAELIDLILRLAKHGLIHGDFNEFNILIKEERTNKYTIEDGEEKETETVTLVPIIIDFPQMVSMDHVNAEMYFDRDVECIKRFFKKRFHFVPTQPGPFFKDAKKTVGKDGAKRLDAAVEASGFTKKMLKELEKAIQEQQAKIDAGEAVEEDELDEDEDEEDDNEDDSDDEEDEEDQQEEEEQAVFEIPASVGRPLSDAEKGLEKLSLGGKGGKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9K1</accession>
    <name>A0AAE0J9K1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_292397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678536.1">
        <property type="nucleotide sequence ID" value="XM_062823025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9K1"/>
    <dbReference type="GeneID" id="87860179"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000013">
        <property type="entry name" value="Rh-like protein/ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF9">
        <property type="entry name" value="SIMILAR TO AMMONIUM PERMEASE, BUT NOT NORMALLY ACTIVE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="23"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="457" mass="49890" checksum="20647AD5177176AC" modified="2024-05-29" version="1">MPEMAVSPVLAAWEACDKTDTLFVLICTVICWSIVPTVGIAYSGYTWKRNALHAAMPSILTIVTCSIQWFIVGYTLAYGEGGWFFGSLKHFFHKGVLSEPVGTIPAILFSEFQLVFEATVCAIAVGGFCERGRLLPVIPFIFLWATFIYCPLAHMVWGGGLLGEGLGVLDFAGGTPVHVCSGATATAISIYLSYPLFRSRKSDIRTPTHIRIHRPGNSFFQLLALIIIWGSWLAFDAGTTLALNFQSVMALCVTNLCAASGALTWNLMTFYETGKWSIDSTFMGAISGLVMITPSAGFIDMPTAFFFGIFGALLCRQALRIKFTKFAQHWRWVDNGDTFATHCIGGVAATIMTGLFAKKEVAAYGGVEVAGGVFFDGNFRQLWVQMVEAIVGFTWAFCGSYIIIALIDCVPGFEVLAVDKNISQGLDMNEVEEFLGNLEYPDEVDYTPTSKGNISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA60</accession>
    <name>A0AAE0JA60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_429813</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679110.1">
        <property type="nucleotide sequence ID" value="XM_062824847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA60"/>
    <dbReference type="GeneID" id="87862001"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="43"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3340168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="376" mass="40694" checksum="68389AAE99259E7D" modified="2024-05-29" version="1">MFRHGVRTFATTSLRRMAAVAPQEPSQYLLNVSKAQGIAQGLTGAIGNTPLIRLNRLSEETGCEILGKAEFMNPGGSVKDRAALYVVKDAEERGLLRPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFENPENYNHQARRHAEHLDNAVWTNQFDNIANRRAHIETTGPEIWAQTGGKVDAFTCATGTGGTFAGTTRYLKEVSGGRVKSFLADPPGSVLHSYFSSGGKLVERSGSSITEGIGQGRITDNLKQDVDLVDGSMTISDEKTIEMVYRCLDEEGLYLGASSTLNVVAAKEVAEKLGKGSTVVTMLCDGAYRYADRLFSRKWLEQKNLLGAIPEHLQKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAB8</accession>
    <name>A0AAE0JAB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_304372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678956.1">
        <property type="nucleotide sequence ID" value="XM_062823194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAB8"/>
    <dbReference type="GeneID" id="87860348"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041954731" description="Lipase B" evidence="2">
        <location>
            <begin position="24"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="49448" checksum="DCD957035079EF1B" modified="2024-05-29" version="1">MILTSRTAVLLSTVTLFAQVAFGLPTTSGPERRNNARAVGQISNRNESSTLREAPESESDLQSRLDGIWASTTDSNGADTFWDKVVRQAHQNILPGQGIDINYIDEPDTITDTLVGPLDPRDSFSNLNNPDVPGVHYPRSSDVDPSFTIPEEALRAAIYLPPGFTASSNRQVVLFVPGTGSYGHEAFGPNLLKVITSAGAADAVWLNVPAAMLNDAQSNAEFIAYAISYVKALIGDDRELNVIGWSQGNLATQWVFTYWPSTVPKVRQLISVSPDFHGTVLANGLCLNAGNLTNDIKEGLPCPPSVLQQEYNSNLISTLRAAGGGDAYVPTTSFWSSLFDEVVQPQIGLTASARIGNARKKGVTNVEVQTVCGVSPGGGFYGHSSLLSHPLVAALTLDALRNGGPASLERIESDIHDICQNVVAPGLELADGIKTAGDIVLAAVRLIAYPAKLKEEPVLRAYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAV8</accession>
    <name>A0AAE0JAV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="14">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_431129</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="14"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679634.1">
        <property type="nucleotide sequence ID" value="XM_062824926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAV8"/>
    <dbReference type="GeneID" id="87862080"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000456">
        <property type="entry name" value="3-ketodihydrosphingosine reductase tsc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3340692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="352" mass="38532" checksum="307773937E8A88D0" modified="2024-05-29" version="1">MEQLQTLSTSWSLPVAAIVAAIGIFATMGLFSSKNHMPVEGRTVLLTGASEGMGRSAAIQLSQKGANVILVSRNVGRLEEALADVRAAAKNPSTQRFTYISADVSEHDYAAVVIAEAIAWNGGRSPDIVWCVAGMSTPLLWTDDDSMAAARRNMDVNYFGSAEMSRAILREWLAPENSTGPKGEPKHLVFTASMLALFAILGYGPYTPTKWALRGLADTLAMEVNYYPDNPVKVHIVFPGTIVSPGYERENQTKPDITVELEKDEPAESPDTVARRAIAGLEAGKYFVDVSFLGRLMQCGIMGGSPRNNWVLDTMMGWFIPIIYFFVLRGMNSTVVKWAREKGHPFTHPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBZ6</accession>
    <name>A0AAE0JBZ6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_428489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680172.1">
        <property type="nucleotide sequence ID" value="XM_062824764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBZ6"/>
    <dbReference type="GeneID" id="87861918"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="237" mass="26531" checksum="F673FA34E11B0C73" modified="2024-05-29" version="1">MAPTAGFPTLADSLEARVDLIWMPDNNDQSSPPDSPGPSTSAQSDHIPESEDGDEGVHNNTDVEHSTQDTSSHVDNTELSQASGSNDMSSNTALSDSVSSNTQDATEDDDDVQEILQAPDVPPPSEETLRSQAIAWMEATYSDVPNGEVIQPPPCYAYSRTEHPERPRIWIKDFFTGHVRPRRLVNDRLVDMSRAERERWANQQRRIRGEPAGSAWQILRRCGHGRCNEIRWEQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC25</accession>
    <name>A0AAE0JC25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter NIPA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_510956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679861.1">
        <property type="nucleotide sequence ID" value="XM_062828446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC25"/>
    <dbReference type="GeneID" id="87865600"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="415" mass="44760" checksum="6C115057EBE4662A" modified="2024-05-29" version="1">MTSSLAIGTSFVITKKGLNQAEERHGFEGDGYVYLRNPMWWAGIGCMVAGEICNFAAYAFAPAILVTPLGALAVLIGAVLGSYFLNEELGTLGKLGSAICLIGAVIIVLHAPPDEDIQTIDQILNYAIQPGFLLYSALVCGFAGFMIYRVAPVYGKKNPLVYLSICSTVGSISVMAVKAFGIALKLTFAGNNQFSHPSTYVFMIITAVCILTQMNYFNKALSQFPTNIVNPLYYVTFTTATLCASFILFKGFNTTEPVATLSLLCGFLVTFTGVYLLNLSRSDPDGTKHLARRSRGDATGTDMISGLQTRMSMERRRSQGRMSTGSTRDRDGLMRAYDEEEALGLADLAEDSDEEDDDPRSPMIGSFRHSNGGPANGNTTPTTSTTQGGRLAPNGKKHAVGDSIEMQNRKKSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC80</accession>
    <name>A0AAE0JC80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_468433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680292.1">
        <property type="nucleotide sequence ID" value="XM_062826960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC80"/>
    <dbReference type="GeneID" id="87864114"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3342499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="565" mass="61780" checksum="968944455A9C2460" modified="2024-05-29" version="1">MTSPPTPPPPPSTLTTPNSTVPLYTLHKNLSPGQGQGQAILIRRSTDGAILLGTPSPSALLNNPSYASSHKQFSTFSPPCVSAGGQVDTNVVRELMKGGVQLEASPAGARGTSEGIGAPEAAARVLNHENLVSLHGEWVSGVVDGVGAVFGSRGFGFVNQSQMAGVLDKGGMMMKKSKSVDKTERWLVWDWCDAGSLKGLIEFYGGGVGECVVWGHVEAATGVEKKKKKGKGGLPRKEELGTVLTEGKPSQVKPGEGFLPESLVWHVALGVLRALMFLHEGKRDVVSVEKDSTVTGSGGFKRVRKVHGPPETEPDWLPILHRDVRAENIYLQHPRGVETYGAVKLGGFENCYVSAAVVMAQDEEEEFERVPLVAMERGEVVDEKELRDRWMEWEDEGDGIDASKRPYTRGNDLYALGTILYHMMVGRPLPPVPEECHLCKCHHVQFLTGAPGEKKKACTHMTCDYQDVNHEVEIGQLINTGTRGKYSKNLAGLVGLLLRQYRSDEKTASDILDRITWKAYEEWKTATPDGKLFKDATDDMMFRKNNEIVAKRNLVAQQNSRPMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCF0</accession>
    <name>A0AAE0JCF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_430859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679687.1">
        <property type="nucleotide sequence ID" value="XM_062824906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCF0"/>
    <dbReference type="GeneID" id="87862060"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="59" mass="6725" checksum="EFAB8F7C39108FC0" modified="2024-05-29" version="1">MTKKTWALDLVLHTLYLERHQLPQSQSGVREPTFELSTTAVASPSTRNPKFWAQQDGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCG6</accession>
    <name>A0AAE0JCG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_467813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680086.1">
        <property type="nucleotide sequence ID" value="XM_062826926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCG6"/>
    <dbReference type="GeneID" id="87864080"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="148"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="342"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="911"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="955" mass="104888" checksum="C3F58D23FE24089B" modified="2024-05-29" version="1">MPPLNTATIGMAVTPTVVSTFFSHYLNRNGVRQKPTERLSYDEGLHLIRSFLDFASSRPVEELQAFTGQWVPHPTWVRVDEVEIPEYELSRAANLLHEQLGPEGIRRVGGREWWQWRKPKSPLKAEWIEMKADYEERKENADPGNRVMLYVHGGAYFFGSVNEHRFMIQRHARKLRARAFAPKYRLAPQFPFPCGLQDCLAAYLYLLTQQEPKTIILAGDSAGGGMVLSLLVILRDQGIPLPAGAVLISPWADLTHSFPSVAGDCPLDYVPPHGFHHRPSRAWPPPDEDEMEELKKIAVEQKKGDGVKEGSSDSNSGIPTIGDVIDKPTRLSLMIDGQQIDIKEQIQMYTTNEMLNHPLVSPIMQPTLGGLPPLLIMTGGAEILRDEQIYLAHKCAHPEKYLPPEAMMDEHAWAQLKQYPPTDVQLQVWDDLCHVAPTLSFTRPAKYQFRAIAQFGAWALARAQRREIDILDDDDVSVISGHEGADESDEDTNQPAVDPTQPNLEPKQKPKKKTNKPKNKRTKTVAEMENEANAVGKAGDPLPPFHQHMIRQRVTTTGLILPLPEHSDLPACCMDRNVIGVIKAGPVRKWLAHKKKFDSRFASTKSKVHKLRIKDMREGGYEVFPGGDVPPPSALAGRRKIGHREKDQKKEKKSWGLSLWGVWGSKHDKMTVARGEKADRAADREVSTKTVQGADGGEGARSYTDIENQEGTGIQGKTAAGVDRPGLGTRLSGSRYKSVADKGQTGPHEGEEHERMQIDDILAYRKGELEEQHHQPPEVGATGKRPIVDGLATPFSLGKKAETASMITLQSGRSRFTAGTGVLQSPPGTSAGASRDNLSLMPGADDAYSSAEAPESGTAVDGVATGSGSALKNEVEVDGDSKEAERIVPQEVEVRNYATQPLDATRGIGMSLPTPLTPGTPGTLGSRPGLDRFVTADEFLSTGAPTPTASEQKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCM1</accession>
    <name>A0AAE0JCM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Quinon protein alcohol dehydrogenase-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_223206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyrroloquinoline quinone</name>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial PQQ dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680348.1">
        <property type="nucleotide sequence ID" value="XM_062822080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCM1"/>
    <dbReference type="GeneID" id="87859234"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.10">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303:SF10">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN ASSEMBLY FACTOR BAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303">
        <property type="entry name" value="QUINOPROTEIN ALCOHOL DEHYDROGENASE (CYTOCHROME C)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="4">
        <location>
            <begin position="390"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3342555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="628" mass="67013" checksum="B321D39FD4ED5DA9" modified="2024-05-29" version="1">MELQSEILGLDQQESTCRKGTRLSHTPLLKPIGLEMPHVSDLGFLLVEYIYAEPAVTLPFDQGPITILTETTTQHGQTTVFVVLSLADPDTHSSDSLSCPLLAVTATDNKARETPWIGWGGSNYNSRWASTNTKISSSNIQSLSEHCHVPGYVGGITATPSVVEGIAYFPAWNGSLVAFDYTSCKVKWDINVTQVILDYAPADPLQAAVAPYPISRTTPQLDLDNNIIYFATLWNALLVAADLKTGKVLATHRINAHPLAQVTQSHTLLGDIIYSGAASAEESVGFLPGVNYTCCTFIGNAIAVRFNRKAKKFTTLWDVPMMPPNDDPSEPGFWSGSAIWGSQPSIDPKRNTIFYATGNLYSVPDPWLACTADPAHPTCELPSRVWQEAVVALDLKTGNVKWVHRLVVLDAWSVACLNATFDAGLCPQTPGPDADFGMAPAFVPRGGKKGKDVVVVGQKNGNLYSLAADTGDLEWAVSTGPGGQGGGLTWGIAVDDKRVYYVTVNSESGTWTPAPQPGSGPGRSTNGSAYGAADLETGEILWETPAPDNWLVGNPPTVVGDLVLLGRKVDTPAEGHLVVLRKSTGEIILDKPLDSHFTGGIAVAGKSLLFGTGFHGVIPGSFYVLSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCR3</accession>
    <name>A0AAE0JCR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_526972</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680577.1">
        <property type="nucleotide sequence ID" value="XM_062828866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCR3"/>
    <dbReference type="GeneID" id="87866020"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="643"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3342784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113016" checksum="562FE040E2E15E9C" modified="2024-05-29" version="1">MPSLSSISGPTYVTSQLLVQQTAYKLSDKIFSYSPETFDLDVAVKEWAEANEKNVHGETTTVVPLQTRAGAGAFALGYIFSKDFDLAKRHVPQTLLAPSLSLRHLRSSLDQLALLYGVSSPFVAHVAAADYNAENGLGADYATALQIAEDLGLALVSSSSAYEVQHMSLLATLLASVLPTLHIYDGIRTARESLRVVDALGEAHIADIYAKISKEAAALNKRLDTAGKVVELLKAFNNELGTSYAPFEYHGHDAPETVLVVFGSAEAQLAKQVATALAAKGKKVGTIVVRVYRPFVEEAFLEVLPASVRQIAVLGQVADAASVEDANVQSALYSDVLTAVSFTEKLSQAPEVVDIRYVVTDAHTPSSIASIFNKLTSKGEAEPVAFSLTAVEEAQQYVFWDVDNSSAVASPAAVGKLLETEQSSNVYVHQTYDNLVQGGVVRTDIRVSQKSIEAPYPVENADVVFVGEEKLLKEIAIVKGVKAGGKLIVRLPNFKEDELEKRIPAAAQKEIQEKNVELYVLDSSSSSALEKEAHLLVNVAFLRVARADITKFDSLSADKTALTEAVNALDQSVRKVEVPVKWAEVEGAVAPLVDSVKPNSFVAFQKEEEEETSSLENWQSAAKGFAFKEAYGTQNQLRPDLAVKTYTIKVKENRRLTPTDYDRNIFHIEFDLGDSGLTYNIGEALGIHAENDPEQVLQFIQAYGLNADDLVQVPSREDPAVLETRTVYQSLVQNFDILGKPPKRFFESLAQFATDEEEKKRLERLGSKEGADEFKRLTEEDTVTYVDVLDMFKSAHPDFNDLIRIVDPSKRREYSIASAQAVSPNSVALMIVVVNWVDTKGRTRLGHATRYLSGLAPGSTITASVKPSVMKLPVKDTAPLIMAGLGTGLAPFRAFVQYRAMQKAQGKEIGSILLYLGSRHQREEYLYGEEWEAYLDAGVITMVGAAFSRDQPEKIYIQDRMRQTVTDIVQAYIKEEGSFYLCGPTWPVPDVTAVLEEAIAAEAQESGRKVDPRKEIERLKEDGRYVLEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCS4</accession>
    <name>A0AAE0JCS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_558692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680216.1">
        <property type="nucleotide sequence ID" value="XM_062830112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCS4"/>
    <dbReference type="GeneID" id="87867266"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="66566" checksum="713133DCFD52B275" modified="2024-05-29" version="1">MAITSAPVEIILYILQSCDSFTELRALFSTCRRIHNVWLENAPRVVWHVAPKVIPAFDWALLAARATALVHDAHRDGRLPPEIRPDDLTGALRKPSLQELDSVLGLHHFVQCVELRYCHDHLTINKAFNQPANQPQNLWPEDRKPPPPINNNTPEDPGEGMRVWTERFHTAAYTSLLMGAVFARAYNQPFYPDVDDTSSSPSGDGHLEDQSPSSEAEARRKELWDLMRKASSDRSNERHHRLTIKEDMREYLRQFPVYDLNNELGGQENVFGPFIEWYIRFTISQYNKTTPKPASRDPSRPAIQLEIDRLYAAFDRGEDVDRCPDRPSKAFMEWDSTQLSESFPTSFVGSPAEGEAVVWAAMQAVHMFEFILTCITNLDGRCRFGRSSVTAKVVLFGIFQAEEILMQVDVKYSIGQQLVAYSPPTHASASSPYTYPDGEGYTYPWSFDDLYNRSGIANQNHGAERPPPPLQLFMFLLEHRFNLEFDYSLFTTHTDGPQSYWLFKKRATIFAHGPELVPERSVLDYTNGMEFLVPLYTRVFSFYNHDDSYFDHLTYHGNPRTWEPDYNYFEELLHLGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD39</accession>
    <name>A0AAE0JD39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 type zinc-finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_231516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680634.1">
        <property type="nucleotide sequence ID" value="XM_062822191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD39"/>
    <dbReference type="GeneID" id="87859345"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3342841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="585" mass="65788" checksum="FE664D7BF5262AED" modified="2024-05-29" version="1">MATISASRTAPMAADVSRMDQGTTHPFTCNTCQVAFRNIDLQKGHMRSDWHRYNLKRRVASLPPISSEVFTEKVLQSRAEVTAQTDKASFEMTCEACSKTYYSENSYKNHISSKNHKMRAAALASRAPAATGRTKADDEVSSVMSSTFSLGEPASEAKSEVDSDAEEEFNEVVEGIKQANIEDAASPVDRPANPHLSAADQHKEDHPVEDAAASEQPETSGTATPTQPEADTALLKQCLFCNYESPTPALNATHMERIHGMFIPEKQYLVDLEGLLGSLRRRVFELNECLMCGKMRSNTFAVQTHMRDKGHCQIPYTTEEEQLEIGEFYDFRSTYSDGDGWDTEDEEEEEEEGAGGAKLGGKREAKVEVEGGEGGDEEGWETDSSASSLDSDDLHAVPGEGHYHQYERLASHRHHSRDDPRPHRQADGFHAHSRKGVNAVYYDEYELHLPSGRSVGHRSLNRYFRQNLHNYPTPEERQQQLLLEAAGGEDAEDAEMQYDSDGEPRFRRNTEVQLRDRKAHGRHVITRETRGLVGANGIRDVESKEVRKVVEKGRQRDRDSYKRAEVVGMKKHFKEVHRNPVSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD51</accession>
    <name>A0AAE0JD51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_576065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680458.1">
        <property type="nucleotide sequence ID" value="XM_062830647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD51"/>
    <dbReference type="GeneID" id="87867801"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="948" mass="107590" checksum="F20ED566465E453B" modified="2024-05-29" version="1">MRMLEDCLDAGLKYSSELAELIDRAVPEADEDEEGEADTEAIGKENLNQWIEDADEISEEHRQFEILVGVQGKTGAGKTSLLNALLGYKDLLPPNDALVATAAICQVAYNYSNDPKTAFRAEITFRKHLDVKHELNKFFGDIKLREQLLNGRGEFEDDDDQEGPDSSDLGEVIARINATAEKIGAVWGHTLTELEVMSTQDLLTKNDPAVKLLNTTKRINAADLSTFAPEVKPYLDATTTTSITGRAGAKTRDMAVWPLIDHVKVYVKSDILRGGIVLVDLPGLGEIVESRAAVARQFYNKLTVSIVVTPSVRAAGEKTAVNLMTENQEINMRMSGKLDDRGYCVVLSKADDGVDWETTARNQNRQKDIKMVSDLNKKIKEGGTAAKKFNLQITKLLQSLKSRKISEEERTKVFNQLREEREKKRKYMKLQRELKRQKKEAHWGQVFTAAQSRSAILAKEINRYLNERHAVFMKSCPGAKTPYCPPKIFPVSVRAYWPLQKKNEDDPDAMPEDPLVGFPEEAYTGIPALKRWLYEATVPPRERHMKALLNRVVGLYYNLQTWSDKECEKIKLHMTPEELQEEYLDVEYERLDLKLRAYAKILSKRVAECNPLKDTAEAMRTCVQQCIDQVNNWIYKDPEGENRYKKLHYATFLAIIKSGGGVFFSRAGGQNKVYDWMEGLAHLFKNQICSQWLASKEPALKAIKEEVKDLICQALIDIAVNSDDVHKELAADIKAKWKMTFKRAADPKIKGKGTMEKRHKILKTFSTHKDNRTYKDAVTKLKKEVSEEINKFPKRLDAIWMIGLNKLRAHVNLIMDKIVEYENLGGDDGMEDMEGEGDELGGSEESRKQKIVLQERIRTMLNRWYFAWNMSPDDVPMHDAEEPDQDEITKTSSTNGSDIPTKFSLGALADGEDESMEEDPLDAIIDLHLSTNLIEDDVKIKEEHFDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEF9</accession>
    <name>A0AAE0JEF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis protein SPO22/ZIP4 like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_187389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681465.1">
        <property type="nucleotide sequence ID" value="XM_062821593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEF9"/>
    <dbReference type="GeneID" id="87858747"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="937" mass="106668" checksum="DEF9733B246BF26C" modified="2024-05-29" version="1">MPIPTGTKDVSQSANKTDKRIEAALDFVRNLYKVFLSDPSDAPATDQLVDQINQHVKKLHNYTYKHVPGVSGDSEIDQQGTRLWNICTRLLRDCEQTKKRLKRLYLYGRVLAFHLLVVANPSQTRKAQNLVYVVKLALKAARDCVESSEFELATAVLQKAADYKSSLQDLASVLPKEELDECNCLEVEYFIIRTALAWADNHIDVAEHMYTKAERLRQYLTPDYAEKLADVLYEIGKSLASRNDYPLATKWLQRANEVINTPTLEHLSREGLELRLAILQALVSALLATGTSTDLDEATKLVDYIESEVGNRPVVSLLKLEVLRKTPAEIFDDDAYADVLRRLIKDFNFSNAGFKLIIHHIRKLHDKSPGAACAVLDDFILSLRGVDDNSWMEKAVITRMWMITNQRDTNETIDTVRGVLSNLTRPLSAEAAVAAQALIWKKLESNYSQKQYDIAENWCRLSLHHIFQNCGPGNMAKLERKLLLCALARNELEAAISVVHNLSKQSWREPMTAYLAFKVAIRCEDRNLAEQCIHTIGQAPDHIDFLGACIAESHKTGDIFCAIAALKKLQENYEYKDPNPINLPALFRCLIRLLNILAEKPDERQEEIISDLCRQFDIVVYALERRANDPKTRKLFTVDELEWFSRNAYNLALKHTTTWDLRCVVRLLTACVNIISHFPSDVASQVEVTLKALFSRFIIASALISFARTQDNVKEQLEDFQLMRKHVLAFDSLVPEYLPRLDEQSREDMVRKHATLLTFDFEAAVALGQWDDLGGIVQRAVPCKSAVAYQTMADSLLRAQVPGQVLYSTMRKIVNKIWDLESFDAVKLAKYTRCLFQATLPLDDTLAMKLLQEACGKARELHESDARWPEEELEWMAATAFNHAIDLYGAYERDRAKEWGSAAVNLAHYCPDGGFERMLQDKFMRLSFEDDGRNREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFJ7</accession>
    <name>A0AAE0JFJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_200264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681848.1">
        <property type="nucleotide sequence ID" value="XM_062821772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFJ7"/>
    <dbReference type="GeneID" id="87858926"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="153" mass="17678" checksum="289CCA80C9A2F8E4" modified="2024-05-29" version="1">MMFCLEERVSSSWWVSLPGKREKRKQNGCSMVMIVGVSIGGDLGGYGFPCHVCCFSFLFYSFLMRYDDVMTIVSFVFSFIVSFCSLPSLAFTQKERWAKEDGRMNRRRVAWWYIQSEGGHGSWYNLCTTDVYYCSNLKRVDEGMSSLVTVISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFM3</accession>
    <name>A0AAE0JFM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_466538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682014.1">
        <property type="nucleotide sequence ID" value="XM_062826858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFM3"/>
    <dbReference type="GeneID" id="87864012"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3345401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="23706" checksum="0E384E901B315402" modified="2024-05-29" version="1">MANDEYDFLFKVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDSKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKGVTFENVNRWLKELRDHADQNIVIMLVGNKSDLRHLRAVPTEDAKKFAEENHLSFIETSALDATNVELAFQNILTEIYKIVSTKNFDNGPSGSTEGHQNLSGQSISLSQTANDPQAKSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGJ4</accession>
    <name>A0AAE0JGJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear pore complex assembly-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_507551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682539.1">
        <property type="nucleotide sequence ID" value="XM_062828147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGJ4"/>
    <dbReference type="GeneID" id="87865301"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="38"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="291" mass="32617" checksum="D94F162C1A0BFBED" modified="2024-05-29" version="1">MLDYTEYNNVFPSPGIINPYDHKGTGAIETFRKSLGGVLFVDRVLSRLGIGQGTAYPPKGENGLRSLHQQICQSSVSSHHKISVLYYLLLDHDDIHPGRSQWADGFAEETGLPKKYQILMRGLWHMDRKEFKYAIENLTHPSLPTEFADEITIALVRSASQSDYTLALAYFHAAQPVFTSSEALELLFGALARTNVTEALDFSRRYPEWTRQQLFERLVASILEQPEKLGARGKELVSAALTGEEESWFQDYLRRGEGRKSKGTSVLLRMRGVVTGRLSSTAALENLAGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGL5</accession>
    <name>A0AAE0JGL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_509250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682196.1">
        <property type="nucleotide sequence ID" value="XM_062828296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGL5"/>
    <dbReference type="GeneID" id="87865450"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="500" mass="56979" checksum="FF116279DEBF6CA0" modified="2024-05-29" version="1">MTLSYRWTDEVKKNKLLGENKERFYESIPTDDWPQIYRDAVMMTGYFHVQYLWIDALCIVQDDPCDWEEQAALMNIIYERGILNLAAPGLHVSRDPLSMFDCLLTRESGEPWVCANVEDELDVLARFPLYQRGWTFQERLLSNRTLHFGRQLVWECDAGLATEVCPELITTKHDATRTIKRTFAGSQYKFPPPRMLVGAFSALWKMVVVSFSKMQLTYSSDKVPALQGITNRLGYRLSLDPADYYVAGLWVVECSQLSWLRESHQNWLTSEDNEVACKPCKKPPSWSWTVCAEAVKIPGGAFQPIDLVVLGAVPVRSRDAGLRHMVTVHECISTVLFKDNAAAREPEPFTGLTLRGKFIHWFQIHTILQLGQRTPEFTIKGYVPTDASKSGSFNIKIILDRPIPEHSSHKGLKLLPIHCNRSQGSSPDEMCGILLAFLGFDEGMALYRRLGQFQVVDLEGSPSCFLRYFHLPRERGTAETHEMPVGLQQELDELPPFKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH18</accession>
    <name>A0AAE0JH18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_547325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682583.1">
        <property type="nucleotide sequence ID" value="XM_062829507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH18"/>
    <dbReference type="GeneID" id="87866661"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="84"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3347501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="486" mass="52295" checksum="B6D6C2E33C9C460F" modified="2024-05-29" version="1">MEFLATLINRGVSHIDAATIDANGSAGHGAHGSGGPAVGPKYSPDGYCGRRLAGLETGPIPNRGPETSAGLWILVSFSTAFLAARLYLKMYRLKGLWWDDYILVLAWLTHTLSATLAQVSISLFGLGHYPCDIPSPATSIPLLTLVGDHFGAMFSMFAVALSKTSWAVTLLRLFQRGSSTPSRNQRQYAVWIVWFVIITICLVKGAQGVLVWIPKCGSPAALGKDVCVMIKPLNGFATFAGSMSGTYDILLAVVPWKTIWGTGLGKREKLGVATTMSVGAVSGGAAFVLAVKMRGITSENFTCEIIVWSTAETSTTIMAACIPVHRAFCRQLRKKLLAQYRLHSSKQHSTPSTGKNGVGGSTTLTGGSTTLTSGNFRSVLDKLSQRRRKGSDGEDEPGCLSLPSAGVCHAPTDDNVSDRAILPVHDRSGSEVATSRNSGKILMTQEVKVEYHHHDDTLNGRDVLDEREQTQQHLYELKDMGRRGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHK3</accession>
    <name>A0AAE0JHK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_422958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683067.1">
        <property type="nucleotide sequence ID" value="XM_062824427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHK3"/>
    <dbReference type="GeneID" id="87861581"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="86"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="265" mass="28772" checksum="ED8BD22AD4305EDA" modified="2024-05-29" version="1">MADRGTSGPRGGGFASRGDRGGDRGRGRGGRGRGRRGGKSEEKEWQPVTKLGRLVKAGKIKSMEEIYLHSLPIKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVIIGDSEGHVGLGIKTSKEVATAIRAAIIIAKLSVIPVRRGYWGANLGLPHSLPTKESGKCGSVTVRLIPAPRGTSLVASPAVKRLLQLAGIEDAYTSSSGSTKTLENTLKATFAAVSNTYGFLTPNLWKETKLIRSPLEEFADTLRDGKRYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI18</accession>
    <name>A0AAE0JI18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_157795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821186.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="208" mass="22461" checksum="EE5AB941A0DBF083" modified="2024-05-29" version="1">MSDYDDDYGYDDYDDYDGGYDDGGYDDGGYDDGGYDYGDYDHGGYEDHGAHDHDSHDAGEDAVAVEYTGFAVIEEVEGGHDHGSAVDGGGHEDHTGYAEYAHSDDGYQSDHDQALSYGVISGGPSYVQDHDDYPASYSPSQYAPSARGASQPSSAPRGLMVDSQSHGGSYSHRPSSRSSGVHYNGNYHGPGTWNYEEQSLRNHSAGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JIY3_9PEZI</name>
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        <name type="scientific">Neurospora tetraspora</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="197"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3350555.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="311" mass="34413" checksum="3CB9951397480C87" modified="2024-05-29" version="1">MPRADPLRHPPLAYVFDHPTNPAVESWLDTLPPLAKEPCRRDIKQWRRARGGESSGHRTWFIFSIIIRAISMVVAIIAWSLNVAVFVESRLYRGGVPGRMIAVLVVAPVIITWNTAEFIAICVRKSSGIPAVYHVWADGILFAGIATTTGIVLVNLIIGIATFGPAYDEPLGKGIVEVAMLLLLMLLHCFLFFNYFCHKLDRHDPGPFVKTTGLSLGDREAATLEGGLPTTQPEPPFRYKSYEHYAKEDKEITSVGQRPDGGFVIDKGVEDMEQTVGASTTIAARQSEDQIRYEIPVLPSVFPPQKSETCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JIY5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">YTP1</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5 6">
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683799.1">
        <property type="nucleotide sequence ID" value="XM_062826216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIY5"/>
    <dbReference type="GeneID" id="87863370"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
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        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="51"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
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            <begin position="180"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3350504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55132" checksum="2F0EE1BEB443E87E" modified="2024-05-29" version="1">MTLNNPAARRGGATRSLIPRVSSSITATAATAVLAAAFIPMASGHDHHEDQIPEGATISVEPLDTTLWLHIFLQTFVFGILFPTGMVLGMIKSRWHVPLQVLATALAFLGYALGHLHKGRQFISNNVHASFANILFLMMIGQVVLGVYLKLHLEKGFQGRIRPFLRILHSINGKAFPLASWVQMVFGGITALGFCQGEHTGQCLAHFIMGSAFIAYGVLLTIVLLVGQLWLRRTGRSQEFFDSAVIAAWGCVNTFTEHRWGTAWVRNDWQHTTMGVIWWAAGLAGVWLSRNRDGTPKRNFIPGFVLLITGWAMSAHPQELMISAMTHKMFGYSLMGAGLTRIIEISFILKDKPAVSDQGYETHSFQYVPVFLLYASGFLFMSATEEQMALVAGSGIDHVAYVLIIYSLAFILFLFVNILIHLYDRTANADSLNKTTHGNGAIRLNGRPTNPETQLRDAGEFELEGLMSDDEDDEVASRRNLLKNERDEGIASPSTAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJA2</accession>
    <name>A0AAE0JJA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_92788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683909.1">
        <property type="nucleotide sequence ID" value="XM_062831576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJA2"/>
    <dbReference type="GeneID" id="87868730"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF11">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="513" mass="57612" checksum="03999748D2E8BF8C" modified="2024-05-29" version="1">MPHDYIPLHNRSKRDMSYTSSFVHKFLNQLQQRQQQHPTATRWDLPKYDATDEADQQVIISRSTPHAFQLGTGASIFTSTLIPAIVSARSEVVFVTCFWAPSKTLSAITDALVKLANHRRGLPNPHDIEPLTVRICFSSRSVFQKLLHPQSHDGYTYSPAEWQKKLVLPDPALLEEAGIRLQVKSLFFLPFSVMHPKFVIIDRQRAFIPSCNVSWEPWLEGCVEITGDAVTSLMSFYALTWEKHVDFRKPLPAIHSSRTSELQDQLLVVPSSAHHLVRPAASSAPLPTLVLPSSHHQNPQFRFLPWQQAAKPPATPLNVAMLELFEQARRSIYLQTPNLTCEPVIAALLDALKRGVHVTIVTGRNMMLLEQLVTAGTTTSWCIRSLVRRFKKLRTHAAHDLESGDPGLGHLRISYFQPRSAAKAAKRGGQARAVNDGQMQDPEEEEPVHSHLKLTIVDREFTVLGSGNMDRASWYTSQELGVLFHDAAFAESVREGVDLVLDQRLSLVFDSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKF5</accession>
    <name>A0AAE0JKF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_456590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684278.1">
        <property type="nucleotide sequence ID" value="XM_062826299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKF5"/>
    <dbReference type="GeneID" id="87863453"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39151" checksum="18EC6185B287B183" modified="2024-05-29" version="1">MTGSPAAIKLNENGIPNFDALPLRDGDPKYSAWGLYGDKDELGTLNRLTDERVAEAAKNEIKTGVRISLNWPLNAQKDSGFFNRKLFHQDLFAKPPRCVNDDVWTFNTQVSSQWDGLRHYAYQKERKFYNGVTMEDIHEEGSDVNGVQAWAQKGMVGRGVLVDHHSWRLEQIKKPNPDPRLVNFDHFATTPIPLEDIQACLESQGTEIKFGDILFIRSGWIQTHTHLTSSSPSTLLSHQQVNPPSFCGLEPSVPLFNYLWTNFSAVAGDQPSLECWPPLATRDPATHGEELSLHEVMLAGWGMPIGELFDLEELARECRDRKRWSFFVCSEVCNVGGGVASPPNALAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKH9</accession>
    <name>A0AAE0JKH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_113906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684609.1">
        <property type="nucleotide sequence ID" value="XM_062820625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKH9"/>
    <dbReference type="GeneID" id="87857779"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="190" mass="22257" checksum="F08B9CF766A3992F" modified="2024-05-29" version="1">MANFRQFRPDDLNKFSKCNLDPFTETYELGFYLQYHAKWPSLFQVAEDQHGNIIGYIMGKLESSPDYYKFSEHYLPWHAHITAVTVAPEARRLGIGKMLTEQLEAAADANDAWFVDLFVRSTNHKAIQFYKSMGYSIFRTVKDYYGDHSSDPTKSSEDAYDMRKPMKRDVKKEHIREDGEKFEVDPSDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKQ3</accession>
    <name>A0AAE0JKQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_97805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684037.1">
        <property type="nucleotide sequence ID" value="XM_062831641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKQ3"/>
    <dbReference type="GeneID" id="87868795"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000071">
        <property type="entry name" value="Conidial pigment biosynthesis oxidase Abr1/brown 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000086">
        <property type="entry name" value="Multicopper oxidase abr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042023855" evidence="6">
        <location>
            <begin position="21"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="153"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="367"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3350742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="559" mass="62820" checksum="D41FC2A73B4F1439" modified="2024-05-29" version="1">MMWSLLLSLALLCFGTVARAAVVTINWNVTWVWASPDGFGRPVIGINNQWPCPKLEANVGDTLIVNLHNGLGNQTTGLHWHGINQLQTPEMDGPSGVVQCPTPPGSSVQYKFLLDEPGTFWYHSHEKGQYPDGLRGPLIVQDPNDPYKGKYDEEIILTVSDWYHSQSIPLVQNMLSPANTRFAPPFPDTILLNDKKDVKFNFVKGKTYRVRLINMSAFASAFLWIDSHPLTMIMSDATYLQTETAYQLHASSAQRYDFLISAIDRDSGNYPILVALDINRDFRNQTLAPAFPHNQTAWLMMDENAPLTRPTNNIDVWRPAEDTHFKPLDNLAMIPSYDHLVKLDFRFCLDANGYPRACLNGKPFIGQKVPALYTAATVGENNTNPIVYGQINPVVVKKGDIVQLVINNQEAAGHPFHLHGHRFQILDRARPYAGDWPGRDVNYNPVPNRRDTVTVWSWSHAVLRFKAENPGVWLFHCHIEWHVEMGLTASFIEGPEQLRGKQFPEDHLENCRIGGVPTRGNAAGNTVDPLDTTGMLTISPTVYTGYVFFFPSFSLLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKV8</accession>
    <name>A0AAE0JKV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PQ loop repeat-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_113247</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684581.1">
        <property type="nucleotide sequence ID" value="XM_062820610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKV8"/>
    <dbReference type="GeneID" id="87857764"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3351286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="295" mass="32735" checksum="B646FE99F6F93E0F" modified="2024-05-29" version="1">MADSTFLTGLSYVFGWTYFTCWSLSFYPQSILNFSRKSTSGTTIDFPLINSLGFFAYTVSNIAFVYSPLIRAQYAARYKGLTPTVQFNDITFAFHGLILCFVTVSQYLFPRAWGFAPSLGSRPSRFILGTFFGCVAGALIIILRVWASPVRNDTSGAPVTEGGWVWLDAIYAVSYVKLVVTLIKYTPQVIVNYRNRSTEGWSILQILLDFGGGILSIAQQAIDSYQQGDWSGITGNPVKFALGNVSMIYDLVFIVQHYVLYRHAAGAKADGEGDSDSDPLLSEDVRVGDEERRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKW7</accession>
    <name>A0AAE0JKW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_123562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684794.1">
        <property type="nucleotide sequence ID" value="XM_062820708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKW7"/>
    <dbReference type="GeneID" id="87857862"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="741"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="922" mass="102364" checksum="1E8F429529A48C39" modified="2024-05-29" version="1">MPGILPMKVIKVGNSSQSRIAQACDRCRSKKIRCDGIRPCCSQCANVGFECKTSDKLSRRAFPRGYTESLEERVRALEAEVRELKDLLDEKDEKLDMLSKMHSNRGRSAESPRSTPAAEIKKDSGTPAKEDTFRVQASPLLLGVENSDSYFMGASSGRSFIETFKRKIQENGKSCTDFNPEAFLHIQGCYPLSTKVSPQSMRIPPRLFSDRCVNVYFQEWAPLFPVLHKPAFLRVYEEFVADPEKIKNNHKLTQLYLVFSIAGLSSEQPDFQQLAACETQWHKSLEAILMDNTMLTLQCLILALMYCTVRADYKRLQYYKGIAVGLSHRLGLHQSQKRFSFGALTIETRKKVFWTLYTLDCFSAAILGLPKLLKDEDVHAEFPSDTDDEYVTEKGFQPSLPGEPTRISSALALFRGSRILGKVLEKIYPAATSYELSLQQMSSLEGELTEWFENLPQHLKLNFKQDKPSTDVTGSRSPLLALAYYYTRILIYRPAIASSLGPKAAPALMSVAESSKSIVQIVQLLEERSMSFSFCLNKADILIVCGMALLYQTLGLKHDSKVLKDNEKLVNGVIKIVTKVNAPGSYDFKRIAGMLVTVEESLPQSLPTPPRQSPEACMPTPPAQQGSPSPSAVDRGAQPTLGRHSSASLSETDLIMQRDKLLGMVMTPQHQQHQHQQLQQQHRNELYRARSQTSFDSLRQDAQQMRPHHRHSMSQAQVAQAALMGRTSTGTQSKQNLDYLSLSSPQSPVSPVQMRSQPQQQQQQQQQQQQQQQQQRSSTASSHSQQGQMFPQKTSTGMSTAEWEALVRSLDGGPVSLYTAIYGGPALAPLETPSSATPSSATAWGQDPWDMSSFNLGDFVPGAPTAQSVLSLSEESISSCDDLPSGDMGLNNGNVDYRNTLLPVTSAGTNNFLLDGLHGYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLE6</accession>
    <name>A0AAE0JLE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endoplasmic reticulum vesicle protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_116293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684676.1">
        <property type="nucleotide sequence ID" value="XM_062820657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLE6"/>
    <dbReference type="GeneID" id="87857811"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041959608" evidence="9">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="216" mass="24586" checksum="1D9917F63FA664E0" modified="2024-05-29" version="1">MTSVKSLLSSFLLLVGAAQALKFDLEATSSYHGNQRRCIRNFVNKDTLVVVTATLDGYKGDGMNVNMHISDSHGNDYGKAKDIAGEQRIVFTSHHDAAFDVCFENHLTGSKYVENPRRHVELDIDIGADAKDWSAIQATEKLKPLETDLRRIEELVGEVVGEMDYLRAREQKLRDTNESTNNRVKWFGMATTFLLIALWGWQIMYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLV0</accession>
    <name>A0AAE0JLV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_458854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685028.1">
        <property type="nucleotide sequence ID" value="XM_062826430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLV0"/>
    <dbReference type="GeneID" id="87863584"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02867">
        <property type="entry name" value="PseudoU_synth_TruB_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000014">
        <property type="entry name" value="PUS4p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="8">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="485" mass="54256" checksum="809E4470F19B6449" modified="2024-05-29" version="1">MIWRSIYKMAHEKLAEGVFAINKPYGMSSAQVIRDCQHHFNPSKLFAPLLAADRALREKENRYQQRRRTHAKRDINVKIGHGGTLDPLATGILILGVGKGTKALHDFLGCTKTYETVVVFGASTDTYDRVGKLIKKGDYSNITREQVEEALNSFRGKFQQMPPLYSALKMNGKPLYEYAREGKPIPREIETREVDVTELELTEWYEPGTHNHRWPTEEAEQAEKNVVKSVWQVAKNQQDGTTSTEEAATLIPEVVEKEVKALADHESNKRAAEERVDELVSEEPAGKKRKTETGAAEPMMSGALKDKKGKDKKQDKYAKNRGLDLAPPPPSPDTPFPWEGKGPPAAKIRMTVTSGFYVRSLCHELGEKLGCGAMMAELVRSRQGEFVLGTDNCMEYSDLALGEDVWAPKIQKALDLWNNKDKAGKAQAVEPVVKKEEPKTEEVKTEEIKAEKIKAEEQPAGEVKVEESAPVKDEETVKTEPETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM52</accession>
    <name>A0AAE0JM52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_419543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685096.1">
        <property type="nucleotide sequence ID" value="XM_062824219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM52"/>
    <dbReference type="GeneID" id="87861373"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="468" mass="51680" checksum="4D84F6407FC32EC6" modified="2024-05-29" version="1">MRTLPPAFLPVSVQQPVVLPENRPKFIPIHQYPTQPPTPRATPAINTARVINESVAQLITQCERTEGSLLAQISYVALHGIIANEGQQAQDLEQVIFWINDFVLGAKHRFDEIRALVVSGLCAAVNNSNGNAKASAKNLCAQSFQHMKKLYLSLLERLIMGLLKILVPLFTFHKDMDTTEALLMLRIEGCKRGWIPFLTEVLRVGKDGAACEYLRTHAQNRGLWNFWSLVVTGNRWAIDAIADARSIDNGLSTSSIKVYLMPMGWDGKRWEGLMSEVTNQKLAWFPERGVYWMIWEMEMLMRFLSPASGGSGSRSSQHPGGCNNNHSNSNHSNIHPPPWSNPPPWSNSYQMNPMANAGNYGQQPQQYVNGYGYAYASPPGPPPNGYNPPPSPADGYGGSSGCRCGCGAKYGCGRASGSGSRKRPREDAYAPPQGSPLNPNRCKPPHAPPDRYDGPSENGSGRRKRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM59</accession>
    <name>A0AAE0JM59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="14" type="ORF">B0H65DRAFT_459563</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM59"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="13">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3351946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="480" mass="52459" checksum="68F07FF69957B1A6" modified="2024-05-29" version="1">MAQASAQIGTPLLTTRQAEELHKSILAYLSSKNLASTAATLRDELDLAEESFDTEKAKKYEGLLEKKWTSVVRLQKKILDLESRNTLLQSEIDNATPSSLSRRTQDPTNWLPKSPPRYVLESHRLPVTCVAFHPVFTSLASGSEDYTIKIWDWELGELERTIKGHTKAVLDVDFGGPRGGTLLASCSSDLTIKLWDPSDEYKNIRTLPGHDHMVSSVRFIPSGAAGAPASGHLLVSASKDNSLKIWDVTTGYCVKTILGHVDWPRAVCPSHDGRYLLSTGSDKSVRLWDLAGGRDAECRLVMFGHENHNLCCAFAPPTAYTHLAKLAGLERPPPPSSSAEFMATGSRDKQIRLWDGRGNCIKVLVGHDNWVRGLVFHPGGKYLLSVADDRTMRCWDLSQEGKCVQTLTGVYEGFVSCIRWAPPVVKDADAKEGGPLADTVVAARRRAATVGIVNATVQIRCVVATGSVDGAEGKVRIFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMD3</accession>
    <name>A0AAE0JMD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase regulatory factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_543602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685644.1">
        <property type="nucleotide sequence ID" value="XM_062829238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMD3"/>
    <dbReference type="GeneID" id="87866392"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1041" mass="112232" checksum="9FF10940F3CBE0C0" modified="2024-05-29" version="1">MAYNGGYEGGPGGRQYGGQAPPPRGPPQRAYTAGPGMPQQQYNAPPPQQHYDQYQEDYGYGGGYDDYGGGYDQGYGGHDQGYGGQYDDRNYQRGPPAQDYPQQDYYNPGPNGRGGPPPGPPAPGPGRGGPPMQGGRAGPAGPMRPPADNGRGGPPAPYPPRGGGYPPGPGRGYPPQGPGGRPGPPDRAVASDPSANRRPPMNGPGPGPGPGPMSPGDRGFGGGNFPPPPGAQRRPDMDNERQMTAQMDGMSLSDQRLPTRGPPGPNGPGPQRGPMRPDTRDGYGGPMRPDTRDGYGGPGPGEPGPGGPQRGPPQPYRPQQDLQDQRRGPPPGPDFGQPGGYQDGGFGPPGRSMTMPARDDMGFQPPPQNFMHRSDSAPYNGPVGRAIQRPNTAQGARAPPQRVYPSDNGAPPLPQNNYDQGYGNRPDMGYGGQQQQQQPGPVDDYYEDYYEPNGNGGYPAQNPPSAQTDGPNFDAIPPHRHKDSFDQHMQPNQMQHQAQRGPGRLPEMSRAKSQPDLRNSQTAVFEMASDIPPIPMMPQHTGGPRGSLESQNSLHRPSPNGQPGPPPPGAGMPPHPVPYRPGQSAPPQGPYNPDNLPSHPAPVRPGQMSGSMVNLNDRPPPVRNYQAAMNSMPAPPPLNNQPGPQPPQSGPSPPPPPTKPVEPKVTVEELEHLRAIVKNDSNDQQSALRLAKKLVEASDVLVPNLPDPKARARSRDRYLVDAHKILRKLEKASNPDAMFFLADSIGRGLFSSEPDHAHAFSLYQSAAKLGHAAAAYRTAVCCEIGNDEGGGTRKDPLKAIQWYKRAATLGDTPAMYKVGMILLKGLLGQPKNRREAISWLKRAAERADTENPHALHELALLYASAEPDDVILRDEAYAFSLFKQGAELGYKFSQFRLGAAYEYGLFGCPIDPRLSIMWYSRAATQEEHQSELALSGWYFTGSEGVLQQNDTEAYLWARKAAMAGLAKAEFAMGYFTEEGIGVPANLEDAKRWYWRAAAQDHPKARERLEELKRSGKNGPKNREKISRNRNSRQQEGECLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMD6</accession>
    <name>A0AAE0JMD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_416078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685665.1">
        <property type="nucleotide sequence ID" value="XM_062824026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMD6"/>
    <dbReference type="GeneID" id="87861180"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="336" mass="35739" checksum="7A1AB622C9E3BD05" modified="2024-05-29" version="1">MYALSCTDGFKYPGSEPTYITDIVPVSAGLAAVGSDQSLSIFNPLRLNQGPLKKVQTNHGNISCAEAFSVGNSVVATAGENGTVSLWDLRTDAANTAVLQIGTPGEGPGLLSLACSEQTNTLAAGTELANHQASVLLWDLRFPSAPKIHYDEVHSDDVTELSFHPTNAHLLLTGSTDGLVNVCDTRITDEDEVVIAAFNHGSVHRAGFLNETEVYAVSHDERFALYDMGETVEKGSPTLDLGDIRKTVDCQYLCNVIPKVTGAGAVIGAGTQDQELFRLIHLSKNGASWSLDSETVVGLPGAHGSEIVRSFCFVDEQQVVFTAGEDSCIKAWRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JME1</accession>
    <name>A0AAE0JME1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin MYO2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_129508</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684952.1">
        <property type="nucleotide sequence ID" value="XM_062820783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857937"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="74"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1229"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1558"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1581"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3351657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1593" mass="180735" checksum="2D2FC2DC519FC4B4" modified="2024-05-29" version="1">MSENYDVGTRAWQPDPTEGWVASEVVKKTVDGNKVTLIFECENGETKTVEVSLEALQSGGHDSLPPLMNPTMLEASDDLTNLSHLNEPAVLQAIRLRYAQKEIYTYSGIVLIAANPFARVDSLYVPGMVQVYAGKQRATQAPHLFAIAEEAFMDMLRDGKNQTIVVSGESGAGKTVSAKYIMRYFATRESPDSPGSRVKKGGYETMSQTEEAILATNPIMEAFGNAKTTRNDNSSRFGKYIEIMFDKATNIIGAKIRTYLLERSRLVFQPLKERNYHIFYQLVAGASDKERHELGLLPVEQFEYLNQGNTPTIDGVDDKAEFNATKASMKTIGVDEGKQTEIFKLLAGLLHLGNVKIGAMRNDSTLDPSEPALVKACEILGIDAPEFAKWIVKKQLVTRGEKIVSNLTQAQAIVVRDSVAKYIYSSMFDWLVEIINHSLASDEVLAKVTSFIGVLDIYGFEHFAKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYLREQIDWTFIDFADNQPCIDLIEGKLGILSLLDEESRLPMGSDEQFVTKLHHNYAADKHKFYKKPRFGKSSFTVCHYAIDVTYESDGFIEKNRDTVPDEHMAVLRASTNHFLVSVLDAASAVREKDLASASSNAVKPAAGRRIGVAVNRKPTLGGIFKSSLIELMNTINGTDVHYIRCIKPNEAKEAWKFEGPMVLSQLRACGVLETVRISCAGYPTRWTYEEFALRYYMLVPSTQWTSEIREMANAILTKAFGASIGKGLDKYQLGLTKIFFRAGMLAFLENLRTTRLNDCAVLIQKNLKAKYYRKRYLAARNAIVSFQALVRANKARNSAQERRTTKAAITIQRVWRGYKDRKQFLEVRNDVIRAQAAIKGFLRRKQIMEERVGNAVLIIQRNWRSRQQLRSWRDYRRKVTIVQSLWRGKTARKDYKALRAEARDLKQISYKLENKVVELTQSLGTMKTQNRELKTQVENYEGQVATWRNRHNQLEARAKELQAEANQAGIAAARLEQMEAEMKKLQASFEESAANVKRMQEEERVLRESLRATSAELDSARIESQRQEAEKNSLRQQLADLQEALEQARRQVPINGDILNGNGIAPQVPTGLINLVSSKKPKRRSAGAEPREMDRYSMAYNPRPVSMAVPGLNRQTTLSGSTFVPGVDSIELELEGLLADEDALNEEVTMGLIRNLKIPSPSTNPPPSDKEVLFPAYLINLVTSEMWNNGFVKESERFLANVMQSIQQEVMQHDGEEAINPGAFWLSNVHEMLSFVFLAEDWYEAQKTDNYEYDRLLEIVKHDLESLEFNIYHTWMKVLKKKLFKMIIPAIIESQSLPGFVTNENNRFLGKLLQSNTAPAYSMDNLLSLLNNVYRAMKAYYLEDSIITQTITELLRLVGVTAFNDLLMRRNFLSWKRGLQINYNITRIEEWCKSHDMPEGTLQLEHLMQATKLLQLKKATLNDIEIIQDICWMLSPNQIQKLLNQYLVADYEQPINGEIMKAVASRVSEKSDVLLLQAVDMDDSGPYEIAEPRVITALETYTPSWLQTPRLKRLAEIVSQQAIAQQEKMEFGSQGGDYQHGDYDTQSMNDLTEVDEGQEIEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMJ6</accession>
    <name>A0AAE0JMJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_9790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685749.1">
        <property type="nucleotide sequence ID" value="XM_062831644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMJ6"/>
    <dbReference type="GeneID" id="87868798"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="73" mass="8022" checksum="A178203236223F86" modified="2024-05-29" version="1">MFLLGMYIVSGLPSIAGCVGLRKTELVKDVAPFYSTGADRRIKPGKAGQLRFRYSLRFDISSFFSLGSNIMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMV0</accession>
    <name>A0AAE0JMV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_4767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685603.1">
        <property type="nucleotide sequence ID" value="XM_062827383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMV0"/>
    <dbReference type="GeneID" id="87864537"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="241" mass="26761" checksum="0F53A9A47219327A" modified="2024-05-29" version="1">MKVISKEEEQAHYREVVKGGLIGGTGGLILGLGGVMFGMKRYQLIRQLSLPFRAFLVTSAGTFGAIILAERYSVTFQRAKDPGMKYLEAGRKKHEAEHLANMTPAQRFKEWGRENRYSIVFASWIAAMGAAMAIVNRNKYLSASQKLVQARVYAQGLTLAVLIATAAFETADAKSGKGRWETVMVVDPNDPTHQHLIEKKIKKEEYEGQNLWQDMVAAEEKRLAHKKAMEEAEANKASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNM0</accession>
    <name>A0AAE0JNM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylate kinase 3</fullName>
            <shortName evidence="5">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ADK2</name>
        <name evidence="8" type="ORF">B0H65DRAFT_30252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNM0"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
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        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ADENYLTKNASE"/>
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        <property type="entry name" value="ADENYLATE_KINASE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
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    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="183"/>
            <end position="218"/>
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            <begin position="37"/>
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        <location>
            <begin position="182"/>
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    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="21"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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            <position position="38"/>
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        <ligand>
            <name>AMP</name>
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            <position position="43"/>
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        <ligand>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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            <dbReference type="Pfam" id="PF05191"/>
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            <dbReference type="Proteomes" id="UP001278500"/>
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    <sequence length="273" mass="30133" checksum="810DF0B960764734" modified="2024-05-29" version="1">MALRRAARVILVGAPGVGKGTQSERLLQRFPQLSSISSGDLLRYNVKQRTPLGIKVESVMKSGGLVSDDLILRLIGNELTQRGWLNSTHPAGNVLTLASSALSAEGAQPFQDDAEVAAFLSSPAQARGFIQSQLSNDPTHSFLLDGFPRTATQAKRLDEIIPINLVVSLKTPVDVILERISGRWVHEPSGRVYNTTFNAPKVPGVDDITGEPLVRRADDDEKVYLARYKKFQETAEPLLDHYARQGVLWEVEGMSSDEITPKLITEFERRFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP21</accession>
    <name>A0AAE0JP21_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_22697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062822138.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="TRANSCRIPTION ACTIVATOR MSS11"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <sequence length="1679" mass="180311" checksum="330563D0D577EE37" modified="2024-05-29" version="1">MSRNKQPLTAATANPNAASAAAAVFKRNETQQASNLSAAAAAAALRARPITPTNVAEVQTKRTVRRSASVASTRTNPDARGRPNLRRSGSSSSMTERTFRSPSPHRPDSRNSGRRQSQSIEDLPPVPALPKNVATTVGTAGAGAPQKSAHRRTQSMGVERVPSQKLGTDDAPSWFGPAKVRDLSSVRRTDPAMASPPSSPPQIAMHQEDRPESRASSINFSYPARVRVGSPPVSPADTRSTTDFPAQDSQSAVQPQRSRGSLLLEAGTPSSTRPRASSASAADKTLVYDPNSRRMIRRSDLLAVEHAIIAASQQPTRSKKKKHPPKAGTHLAQGTVGRTKSNVPTSDQTGNTGTTRTAPQVQVPAPVQQSPAVHDSRQETEERSPSRSAVTSPATEPQSTEQPQEEDSEVEEEVITDHHHPTTSTPMVVTKDGRPMVRRLPSIVREEPELEESESDETNTSRVSSALDSVPSRQRIVSHTRSQSEQQPIQSSSQASLLPIRAASVSQKKNQPHRTSSISPARQAHFGPVQDTLTVRHSPPPRSVSPRKSALKQTSPVRGPSPSDLSSEASWSTDRPVKRKKSVRVSFDDETQPAVAEPAPKERSISPPLASPTGIRRWANADLSATLDDEEVMKPRPALPSFGSVRNVRKPQLQEAKEDERPLRPIGDVAYTTPYNTPLPLSPMAESFAQSSDYAIGGVLQREREERVRSPANISRFREPLPPVVTSVEGSGYASDSDGSTSLASEMTGSLYEYPSFMDPPQQPRRNSLSSPQVSPVKTAFQNGNTPAIDSRFAQEEARRRNSAPNIPIISLTQPTPPVSQNETPKFFVEVPGGFPEDSDTSKSSATGVEQVTGQQTTGTQSQPTSESESDDSSVYADAHEDLSEAEGEGFQSLNAVLDFPGANNSRQHEVPDTPSPPDPPRSLVPALSTATTAIGSHSGESPQEDDWERAKAYWRSLTAERRAQLEREAKEDAGIEGDREEMSAPVEKPRRKKSVERRNSERQALAVQTARQMMLEQQQQQQQQQQAPPQEEQPRKKKTKGKAKETATPAPAPARVIPERTYQIKPGSKWEEPEVPVAPVASTMTMRTTMRSAPPQPKAAPVNDGPRLRKSLRSEPPVDRRASYPDPAPVPSTPQPTKRERRAASEANIPRASTIRLASTHQSHVKRRDSTSSESSFKRARASSAGNGLSAGGFPKSLRPNSPAAGSVDSRGSGSKLLTSLRAMTPTNSNSRLDTPPSSRGTVGSGMGMGMRTTLRDSAASNGGRRSSGGMKMPTLGKKGGASEKKRTSTGSKFSSRFGDSSDEEDARISSRFRSRFDESSDEDEVVPPVPVVPSRLRGSASAPVAAAGRSMALGSMHGRQVSIAEEEEGGYDYSNGVVNGNGNARGSVGSIGGHQKLSKTARLGSAISSTQADYDNDVAAGNEELSRTRSGRGHILPTSQTAPNVRTSDIPAAAEQHRPKRGLMSVFSRKKYHHQHVQEGADAIARPEAPTESAVRRDTKLERSKAKLKGLRNQGQVDQDQEVDVEERLRTPATIDTNNTSEISPKSHPHPRLQKRGSIMPSFSLPGRGEKAPPPVEETMNGGGIPMPGFIRRSGTTTNLNSGSLGTRSISGGSAHPNGPFAPGLASRRTSTATALSAVGTAGNEVVPPERSETPTGKKKKFGALRRMFGRTDNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPB0</accession>
    <name>A0AAE0JPB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_27424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686251.1">
        <property type="nucleotide sequence ID" value="XM_062822790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPB0"/>
    <dbReference type="GeneID" id="87859944"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041775765" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="59"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3354873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="655" mass="70261" checksum="8E54030F667357ED" modified="2024-05-29" version="1">MHLPSSLLIAAPLLATVSADPIRIAQRDVSLVSTSTSEQLAVRALPDSPSGGYAPAVVDCPKTKPTLRKAQDLSQEEKNWLSTRRKNTIEPMRDLLKRANITGFDAETFMNEAAKNISQLPNVAIAISGGGYRALMNGAGFVAAADNRIKDTTGAGGIGGLLQSSTYLAGLSGGGWLVGSLFSNNFSSIETLLNENKVWDFENSIFKGPKEAGISTVNRIQYWSDVAKEVAKKKDAGFETSITDYWGRALSYQLIGDDMGGPAYTFSSIAQTDNFMKADTPFPILVADGRAPGDTIISLNATNFEFNPFEMGSWDPTVFGFAPTKYLGANFSNGVIPSGGKCVEGLDQAGFVMGTSSTLFNQFLLANITNYDGVPDVLIKAVDSVLKEIGAKKDDVSQIIPNPFLDWNNRTNPTADSLELDLVDGGEDLQNIPLNPLIQPLRAVDVIFAVDSSADVTNWPNGTALRATYERTFGSISNGTLFPSIPDDWTFVNLGLNNRPSFFGCDVKNFTNLKTQTVPPLIVYVPNAPYTALSNVSTFDPSYTMSQRNDIIGNGWNSATQGNGTLDSEWPTCVACAVISRSLDRLGRQTPAACKTCFERYCWNGTVDSRDTGAYLPGFKIADAHAEDSGAAAIGKMVNVWSSVVVGVVAAVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPM9</accession>
    <name>A0AAE0JPM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonucleases P/MRP protein subunit POP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_46488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686770.1">
        <property type="nucleotide sequence ID" value="XM_062826777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPM9"/>
    <dbReference type="GeneID" id="87863931"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="556"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="742"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="807"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="939" mass="103763" checksum="552C5096B69477B6" modified="2024-05-29" version="1">MDNNKKQAASGKAADSKKRKEAPSAATGTKNQNQQGKDSRPPARPQKRVKFQDARNIRSQPSDAALDDGKLDLQKFLHAREFEIKALETSMRKCKSANATRVFQQVPREMRRRTASHNAKRVPKRLRDRAKREMLEDNTPTVEARKRRPRTTRARIRAENAKRLEKLAAKKRKRALQREAEGENKDEPGKTTIQTRAPRPKIRRDTLNEPPKPKSKFKKRQINKTWLPTHLWHAKRATMTEPTKPLWRFAIPLTPTQKCYRPTHRASGQKGTVFWDTSYMSTVRLYGAAGGIEQVLKALGLVQESLWGNRGRKWRNGTRTWSGMVSRQQGSSRRDVGPATIIWNPTPTDETTAPESNTTEQKKTQRQILIRTHPSCFLELFDELVKLAKLQTPQVHVEDLRFEIGSIELTGPGSTETLLAVLQPYHTEERHGQVFSSLVGVTNPASLPKDAVLGFSVKDPRLSYPPKRVDTASKVSDPALLDTLTQWPVEEQVKPYGLFDRDVRFKASSLPPQKSINRRKGANIPGQEIQVTAADPPIPVIVFASRPTAGGQAQGTWTLLAPWKCILPIWYSIVHYPLSTGGNPRLGGLNEQRQIAFEQGTAWFPGDFLGTNAGVVWEMEQRAQRKKAWDRRPKGKRIEWASLDLGAGRKGEIGDGLACDFEHLFGLPKDPSPSSSGNQSTLDVDPNAMDVDPGEEAEAASKLGKPHKDTLPSLATVEQMKKTEFNALVSSANLVRPPPRSIISVNITFVTRGVANACARIYRLPSRPSATTTVPSSEAEVPATDPVAAGIGSLPADLRDQWLQKLPSQKSGSRCSKTTTTHAAPHIPHGVDQGTRKQLMAKSLLSGDPLPYPRPSAANQTDIGGGHPLCPGEEDLIGFVTAGAYSLSEGKGTAVGAISAEKAFDTLQECKSGNNKEGRLCIVRNAGESVGWLARWELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ51</accession>
    <name>A0AAE0JQ51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_54243</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687024.1">
        <property type="nucleotide sequence ID" value="XM_062829204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ51"/>
    <dbReference type="GeneID" id="87866358"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.830:FF:000009">
        <property type="entry name" value="Isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000036">
        <property type="entry name" value="Isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.20:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="34"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="713"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3355646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="962" mass="107075" checksum="55325B34FD86CFA9" modified="2024-05-29" version="1">MSKNWSSTLRLPKSTLPPRPLPTQHKEYIKKCADDFYKWQAANRPADDTFLLHDGPPYANGSLHAGHALNKILKDIIIRTKVQQGQRVTYIPGWDCHGLPIELKAVSTEQGKTMTPHAIRQAARDLASKTVLEQMNSFRTYAVMSNWENRWTTMDMAFEINQLRLFQKLVSRGLIYRKFKPVYWSPSSGTALAEAELEYNESHISKSAYVRFPITKDSTAIPGLEGFTGNLYAVIWTTTPWTLPANRAIAVHDDLLYHVVRVGEDAYLVAEGGLERVAKVLLGEEETPEILATVPGSQLTQLQYINPLQGKAAAPQPFIHGHFVTPDSGSGLVHCAPGHGFDDYLICKDLGIPVSAPVDNDGIFTEEAYPDDPSRLKGIPVLEGGSAAVLELFKDNVLNVHKYKHKYPYDWRTKKPIIIRATAQWFADVDNIKELALKALEEVKFVPESGRSRLEAFVKGRSEWCISRQRAWGVPIPALYDANGDAVMTEETIEHIISVIQERGTDAWWSDDAHDPAWIPASLQGKGPFTRGRDTMDVWFDSGSSWTQTDRQADVYLEGSDQHRGWFQSSLLTRVAAMAVQGPTPDGTTNAVGLSPFKTLITHGFTLDKAGKKMSKSLGNIISADQVMDGSLLPPLKVKNKDRDPNAPPPKDALGPDALRLWVASSDYTSDIVLGEPVLKTIHQSLTKYRTIIKMLTGSMEQSARTTPLTALDHIALVQLKDTMAEVERHYKNYEFNKAFSSLNRWIANDLSAFYLEALKDRLYCADGGGVLEPIFMGFLRMLAPITPVLVEEAWEHRPAWMKEDPSILHPLHQLYNSPLIDSNRLRYDEAVLRKDIPVLMETHAAIKAASELARRGKVLGSSLGCSVVINAPKDSKALSVLQKYKDELDAMFVVSSVDLGGAIEGGPAWKYVQDFEMGGQGCQAWVLPPKDHKCPRCWRFVAPAEDSLCVRCEDVVGEGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQP9</accession>
    <name>A0AAE0JQP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_42206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686662.1">
        <property type="nucleotide sequence ID" value="XM_062824379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQP9"/>
    <dbReference type="GeneID" id="87861533"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="154" mass="17394" checksum="23033FF472F92C49" modified="2024-05-29" version="1">MQVREWWRRSGSGIHTCPDTQLFKSPPQLHHFLSFLFFFSFLIPPTAFPSGVSSSAFHQSTSTKKSSSCLPPNDFSIINLKTRCAQDDHIMFPQFRQPAHFRNAPAGVEHRVETPQPAFRPGVANREPVSGESVSQTRKRFERPVAPPRVCGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQS5</accession>
    <name>A0AAE0JQS5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_544574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686692.1">
        <property type="nucleotide sequence ID" value="XM_062829303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQS5"/>
    <dbReference type="GeneID" id="87866457"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="338"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="697" mass="79295" checksum="C7FE96345692FC85" modified="2024-05-29" version="1">MHHIRNPGLDVSSKSGKAAPPGDTNRPSNWGRNAGQDSGNVAQAQPDRAFRTKSPSPSNKRESSRSQSPPKRSKTSGRQGASGMTDDARAEFDRGPTQKGMLWDPQNDSTRTRTQSYDKSNVATSHKLALAASQAKPRRQSQQAQSQPSRTAAQSEDMSIGFLKQPETRAISQEQLVTEVKGIYAGLVMVESKCIEVDNAQNAETDPANKPINHEQWQALIALHRTLLHEHHDFFLASQHPSASPALRRLAAKYAMPARMWRHGIHSFLELLRHRLPGSLEHMLTFIYLAYSMMALLYETVPAFEETWIECLGDLSRYRMAIEEGNLRDREIWTGVSRDWYSKASDKSPTTGRLYHHLAILSRPNAVQQLYYYAKSLCVAIPFNSARDSIMTLFDPVLGPDSSRHSRLHHIDLAFVQTHGVMFSGKSQDKLEHYMENFLKPLDNHIQVSGYQWREPGYHIAIANCCAIIGWGNEKNPVYRAIKAKASVSDESRDQTMTGTEGAEPDLQLVTALRLANRTHDVVFRQQDDLNVVPYLHATLAFVYHMISLPEAMVHFAPEFPWRLVSYQLNSLLRDYSAYDRFESDQFPRPENEEVPRPLPEDFAMRGLLWVEKYFPSDWFSEDKIIDDEKYFESASLFDERITRVLYLGYRIAMEGEGKWLQYDSKTHRFGVHPQYELESQRGGNDYGELPDAAAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRG7</accession>
    <name>A0AAE0JRG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_536616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687472.1">
        <property type="nucleotide sequence ID" value="XM_062829051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRG7"/>
    <dbReference type="GeneID" id="87866205"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3356095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="543" mass="62161" checksum="894ECEFB5F89B8E9" modified="2024-05-29" version="1">MAVITTYLPIVVGIALLIRLLMVGRRPKNYPPGPPTIPILGNLHLMPTKDAHLQFEKWAREYGPVYSLILGTKVMIVLSGDRAVKDLLDKKSNMYSHRMEMYIGQTLCSGDKRILMMGYTPKWRTCRKLAHALLNVSSAKSYIPYQMLENKQMLYEMITQPDEFLYNIRRYSNALTTTMVYGWRTPTYNDEKMQQLFDGFSEFAEINQTGMAALIDFFPILRYLPDFLLPARKKAKELHKKELGLYKGHWLKAKADTLKGTITHCFCEDVVPVQKKEGFTDDEAAYIAGTLLEAGSDTTSSTLYGFVQAMLLYPEVQRKAQEEIDRVVGPDRLPTMDDEPDLQYIRAIVKESLRWMPTTIMGAVPHATTQDDYYDGYLIPSNAGVVNNAWAINNDPVRAPEPRKFKPERYMDDKLSLADSAANPDPSKRDQFTFGAGRRLCPGIHIAERSLFLGVSRMLWGFNIAPKIGEDGREIIPDQERLTQGFVCMPEEYPATITPRDERRKKMMEEEWFAAERECLDPETKQWKQGMNWVPKLTTSTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRJ7</accession>
    <name>A0AAE0JRJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroin-3 related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_565305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687480.1">
        <property type="nucleotide sequence ID" value="XM_062830281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRJ7"/>
    <dbReference type="GeneID" id="87867435"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="65364" checksum="F4F4F81CA65BAF19" modified="2024-05-29" version="1">MPAIDVAMRRSVQGGIVDGFVNLLVRSVQPALQPRDVVQEFNDVKTAFSSWDNCMQAAYCKWTAIGLMIFAGVVIFAVCWCIGRCLCCGLSCCCECFRCLQCCGNCCGCCDPPGSRKHKYLDAPFVPPDQGYKAAEPMDHGFGSRPAPSYSEPSYNTKASEPQYAVFEVDKKRQTMGDSLPAMPEWEGAGSKKVLVEEEAVELDQLKKPEEKTTQSSGAGAGAGAAVMSGAAAAIPAAGPGRGTTPRPSPPPGGQQSPYGVPAGNNGFYGNNGGYGQQNAQGYNQMPLASPYGQSSSPSPYGMAASAMGPAAVGNAGYNAPGGGYGNQQQDAYGRYGEPTRNNTYDSARNNTYDSYGASTNSPASPYDTSPYDNYNSGNQGGYGSSQQQQPYGLAAGGAAAGMGMAAGSMGPNRVRSPPAATNTIPYPKNPMTRRSPAPEQQLNGLGYGGSSNNQAMAGGDSFLGGPRYHSPAPQSTGVTGGGYDSFSNQPYSQGSSQQQRQNTFGGNNSYGGGNNNGYGGNNAASYGDMMRSTPSPAPTGPLPKPPVRNNTMGGQNTLGGQNTLGGNSGGGGGGFDFSSGGNSRPQPGMGQQQGGGMGAQDEGGAAGYPGYKPYSPVGGGPRGPGGGGGAGGVGGGYRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJB1</accession>
    <name>A0AAE0MJB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_78965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676461.1">
        <property type="nucleotide sequence ID" value="XM_062831420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJB1"/>
    <dbReference type="GeneID" id="87868574"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="86366" checksum="F7F2EFB5863DCB50" modified="2024-05-29" version="1">MYLARTRCQNPLPSSSPILSHHQSPVDRWTTQSLVSGWRRYGNLIKNSNSSSAGGLQTPPYDDDMGTTYQVPNLTPSYEQYRSYTHSTLPALSSCSAVSQRPPRDLAHMFHSESLSSYSDTQSIYLPNPQQRSTAASSTSSNTGLAQRGYVQQHQQYQQQQHQSRQPSSPRRQYPQLYVPQHQQQQQQKQQHQSRQPSSQRPSRPPSPSPIRREQEISARDAAMALHSLQVPACISPKGGSLSDLVADLTALFWFETSKLLEQAATYDALRPGAPVRRIEGPAIACPNFKKWVHNLLSTTQVTQNVILLSLLYIHRLKVLNPKMHGLPGSEYRLLTVALMLANKFLDDNTYTNKTWSEVSQLSVNEIHVMEVEFLGNMRYSLLVTEKQWEEWLVKLARFREYLERARQVPSPADLLAPSPNALPVSALPSPTTVQHFPSPLQPTLAGQSPSASFYAKQSSGQGWPTHAAGQTPIWNPASTPLSRKRSMPEFDLSEPPAKRRTPLKPYASSETLYPTVTAPQALRNPREFACAPLPSTSDIASKQARLSVSNLTLNNAQSSTANTLPGEVYSRVSYAPESMISLPPILLPAPGMASTYLNSTSTAAPIPSILPTSGSGVSPSTVVAASTTAHPTSQYALPASRLQSQHSLTSSGAYLGSSPIGEPLIHTPMSSSPSNIYLQQRTSPYRPVRHAETLLHPPPSAFLQQYHLPNPIPPTQLHYQPLGRRNEVRTGIVPEFAMPNSGLTMAGAGRYQEPIPAFRQSFSLPLRDLPPTTSAYSQQPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJE1</accession>
    <name>A0AAE0MJE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_512827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676833.1">
        <property type="nucleotide sequence ID" value="XM_062828607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJE1"/>
    <dbReference type="GeneID" id="87865761"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041930140" evidence="1">
        <location>
            <begin position="16"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="265" mass="28961" checksum="CA6A641D2A93813C" modified="2024-05-29" version="1">MHILLFLTFPLLSSCNSISKISTPYGTWNLKFGTTEVHNNITLYISRPPSDSSATVHPNTAILYLTDVFGLALPQNLLLVDSFARAGYLTVAPDLFSSSPAPGDINVPGFNTTLFLSQHQPNVTDPIIASTISSLRSCLNVTRIGAAGYCYGGRYAFRFLDDTRPPEGRVDAAFTAHPSLLENQEILGIQGPVSVAAAENDELMPPERRAEIEALLRQTGREYMVSLYSGTGHGFAVSADLSDRAQRFAKESAFLQAVRWFGEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJQ6</accession>
    <name>A0AAE0MJQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_329600</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676881.1">
        <property type="nucleotide sequence ID" value="XM_062823492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860646"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000155">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="953"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1186"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1225"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1266"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1319"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1445"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1526"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1558"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1588"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1614"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1644"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1737"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="1782"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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            <end position="176"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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            <end position="216"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="233"/>
            <end position="313"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1055"/>
            <end position="1076"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1988"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2098"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2173"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1997"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="2018"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="2103"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="2186"/>
            <end position="2201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3334715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2201" mass="246773" checksum="ECD072A9F8DA86CE" modified="2024-05-29" version="1">MSDHPTPSPRRASVSSASHQQSIPLRDLRPVPEGQEGGGGRTSETNDNVRNSGAGLQMPSPSAAPISANLPGLSTYWEHPYPDRSAADSPIDHMALQFALPPNISGHGHDPYSVPNPYYEERTDTDSLESDSVPLKPAAQPIGRLDAPEGEAVPRDSFQTVSDLGDGSSRPRNTMLGFDLENNFTADRHRSYGDSLVPDDSRRRSRSLSTSGALSRAGSIMRAMSQRVVMISGEGDLIDQQSQRDRSRSPSMERPRPGHASGPMLVDTSYPSQIGQNPTEKRPESHHVYPQQHPAFRPRSRHDPRNNPLKGKSLGIFPPDNPLRLWLCDLLVNPWAEPFILVLIVLQAVLLAVEAAPDVLADGNGRPERWGSTRIDWAIFVLFVIFTIELIARIIVSGFIINAPEYEEAKNKRRFRERLAEQYRVIFRPQRQRSVRQPRQEQFEPAPFTRSFTMAHSQIQTLEDQQRRHLARRAFLRHGFNRLDFVAVVSFWISFVLGVTGLESKHHLYVFRMLSCLRIIRLLALTKGNLIILRSLKKAAPLLVRVSFLMGFFWLLFAIIGVQSFKSSLSRQCLWINPDDPTNFQAGYTPDMTFCGGHIDNATGETMPWVYSDEKESLTDLKNGTSRAKGFICPRGSICIRQQNPFNGTVNFDDIGHSLELVFVIMSANTFSDLMYYTISSDFLPSALFYGAGIIIMMLWMTNLLIAVITSSFQVIREESKASAFTADEPPGMTSSRVDDAVRRPTLLQKIYNRTKPLWILIVAFGLLAQSLRSARMKSDRERFVNIAEPVVTLLLDVEIIIRLAADIRGFHRRKRNLVDLGLAVATSIILIPPIRNSGQVYNWLTAFQILRVYRLVMVIPMTRKLIRQVLGNVTGIGNLMSFVFLITFLMAIFAAQLFRGELPRQDDDGDEIRIPFNTIYNCFLGMYQVMSTENWTDILYSVTASTHHLHTAWIGAIFLVGWFILAYFILINMFIAVIQENFDVGEDVKRLEQVKAFLQRKELGHSSSSNLALSKVFNFGRSKKQRDPLDYGPAMMEMLLKEAVVHDFLDDDMDPLQQSAPDGQPTPHLGSSTTMEYDGVTPGILSSFWGKFVSLFTSREPNPFYSNVNLDGLGENLDPRTMAAQAMNATKRRQRQQREYLMRHPNYNNSLFIFKPRNPIRRICQSLVGPGRGTERFEGAPPNTYAWYTFSTLIYAAIVAMVVLACITTPLYQKEYFEKYGKTAFNWFVWADTGFAIVFTLEALIKVIADGFLWTPNAYFRSTWGVIDAIVLITLWINVITLFTRNGAVSRAVGAFKALRALRLLNISESARDTFHSLLIVGGWKILSAAFVSISLLIPFAIYGVNLFHGKLLACNDSSEGIVRLDDCFGEWNSTPYNNDWPVLAPRSVSNPYFSFDDFGSSLFILFQIVSQEGWVDVSFALQAITDRGLQPQSGAPYSGQGNALFLVVFNLLATVFVLTLFISVFMRNYTEQTGVAFLTAEQRSWLELRKLLRQISPSKSSYDESKNKWRIWCHKRAIEKRGKWYVAITSVLVFHLVLLLSEFDSEPDWWTDTRDALFLLFTLIYIANIVIRIAGLGWSRFRKSSWDMFSLVTVTGAFATTILFMTNTKLDTYIQLHKFFLVAIVLMLIPRNDALDQLFKTAAASLTTIGSLLATWLAFFLVFAIALTQTFSLTRFGEQTDYNINLRTVPNALLLLFRFSCGEGWNAVMEDYAKIKPPLCVEGVEFSDSDCGSTAWARALFIAWNIISMYIFVNLFVSLIYESFSYVFQRTSGLAMVDRDEIRRFKEAWRSVDPSGTGFISKEAFPRLLGELSGVFEMRIYESHDSVRQILEDVRGEDTSSIRHASIVSTTQFQTSLDLKKLNERISQIDVAKVRERRRRFNIFFEEVMVSADPERGISFTTVLMILAHYKIINDSKSLRLEEFLRRRSRLQRVEEEIHRRTVLGFFDMIYYSRKFQRHMELKRSARLTAIPQLGVPEIYVDNDQTDNEQQNKDSNGNNSARASGSGSGSAAGTNPFESTPTNPFGSGSSTLNPGGAASFLSADNARAAHHRSWSGVSADLSSFDTSYGHPLAGPRANQSSNSASHRNTHAYSFELHDSLGTGGGNAPSPGGWGGGSGTIGSMGLGGGSGLDDNNGGRSPGGDGAKRGSSVRPAQLSSMLDDSVWVASIRRSATMRRGQNNTDWGGGSRTSGGGYSGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MKP1</accession>
    <name>A0AAE0MKP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_481225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676805.1">
        <property type="nucleotide sequence ID" value="XM_062827622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MKP1"/>
    <dbReference type="GeneID" id="87864776"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3334639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="348" mass="37395" checksum="870114F44FAD5832" modified="2024-05-29" version="1">MDTTIELVTTTAVAAATTATAASNTSSTEHIKELIKDLLIASLQPNKTVIITGLLIVLLFPILLHQFLHGDESGSSSKNSSLPSILLAGPSGAGKTALLTLFEKRAGRKTSTSTETDEKKSTEPAATHTSQTPVSVQLNAASSEEDKVKKFLLIDTPGHPKLRSTALSHLLPLDPKTGRPLPPSKTSQIKGVLFLLDASTLSPSSPDSSLSQAATYLYDLLLALQHRYSRYTKGSKHPPSIPVLIAANKLDLFTALPASLVKKELEAELGRIRVSRSKGLLDSGVREDDLGAGEKEEGDDWLGEYGSERFEFRQMVEFDIEVEVVGGSVVGGEGPGCEGWWRWVVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNF0</accession>
    <name>A0AAE0MNF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_479274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677976.1">
        <property type="nucleotide sequence ID" value="XM_062827520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNF0"/>
    <dbReference type="GeneID" id="87864674"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042222448" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19811" checksum="9D35AC914400AC97" modified="2024-05-29" version="1">MTGSFPIQCLSLLLTATDCLVSASFCSVLSLCFPLSSVFHCIISQFSTPSIHLLRLYPGRAGTPTFKHFTAHQREGVKGTLHSALCDLKIIQTRQAKVSSILWHHQRPSNPLSYSRVFGSAHFDRNLGARSRTYSSTNPDDGLYTGRATWNTRDTVTPAPRASSTPVFCLDLGIPGPISQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNF2</accession>
    <name>A0AAE0MNF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_434945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677554.1">
        <property type="nucleotide sequence ID" value="XM_062825167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNF2"/>
    <dbReference type="GeneID" id="87862321"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="343" mass="37339" checksum="716B43E3A1756241" modified="2024-05-29" version="1">MSLTPSSLVYLEGERNIDDWEQGLEAELDCLGLTDYIFGTVVEPDQVAKPDAHKTWFTQRANAMKILLATLKNQAVITTLTINGWDRKNKDPKVLYDLIQSCIARVTNEARSEVLAEFLAIKRANFDTMASFLNRYTLLRKRVQDAKFEMTDDFEVTLLFNAVKHHYPVDARHWAASLEDKTLTVGGLLAKLSNIGNAESRTSSINVNIQMSTNGNSNSNTGGGSSDNKGSKKEDKRVDCPKCNKKMYPSQKHMACGHHVTAKADICWFCNPDKAPDTWRPKKDAIAKKAGTSGTAAGTSALGNNASTNLTTPATAAPNSALLYGGGLFMGMSGIGAGSMDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP46</accession>
    <name>A0AAE0MP46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_476291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678741.1">
        <property type="nucleotide sequence ID" value="XM_062827356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP46"/>
    <dbReference type="GeneID" id="87864510"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="72" mass="8347" checksum="6280F2F50E3BBB61" modified="2024-05-29" version="1">MLKMDGCSSFSSFLLSFFHSFIHSYKIVLHTGGGCQHMQYDTIRYDTLEPRIPPTRCSIFVSLSVHRDLFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPL0</accession>
    <name>A0AAE0MPL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_511654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678814.1">
        <property type="nucleotide sequence ID" value="XM_062828504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPL0"/>
    <dbReference type="GeneID" id="87865658"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="249" mass="26456" checksum="CA9F52924D491B71" modified="2024-05-29" version="1">MGPASVIVLCVFLAVVAAAIFYILITRIQATKLGLPPPPITSYIPFWPEPSNSLPYANNTSSSSGGIKGWFGKFKKNNNRTAAGAYEPSGANANAARSRGFGPLDPDEAWDARVGHEADGYGPTYYEETEMQPPRHNNLGDDTSYGGSSYQMNLATNPGNTGTSNPFADPDEERGRKRSRSPGPAANKGLSAPASQNPFDDAAADQSNVSMRGVSPRPIEGTGASKPSGHNNGEPESHAERRSIFREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQI8</accession>
    <name>A0AAE0MQI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_496161</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680613.1">
        <property type="nucleotide sequence ID" value="XM_062827794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQI8"/>
    <dbReference type="GeneID" id="87864948"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="241"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="510"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3342820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="805" mass="89467" checksum="3DE5036E077B82F4" modified="2024-05-29" version="1">MTVDKKRKNTKAHASGPKRRKTQQQSKQTKRPVSVDALAWKTVDIPEMFDDAEGFFGLEEITGVDVVKEGDVVKFMAAVPKSKAEVEDDGEEFGGFDDEETPKPAENADQEVSTSDSKVEAVKTPAKDKKAPKDQKKPKEQQKEQQKQQKQQPKKEQPNKAANKKNAEDKKKARKNEKTTVEPKDPELETDLFTKLEELPEPEEEEVDMSEWVPLDLSPRMISSIAKLKFTKPTVIQSKAIPEIMAGHDVIGKASTGSGKTLAFGIPVVESWLSAAETRKQNKEEKKGATALILSPTRELAQQIRDHLQALCKGLPMAPYICSVLGGMAVQKQKRQLQVADIVIATPGRMWEVMSSDNSVLASLRNISFLVLDEADRLLKDGSFKEAEEIFKALDRPPVEENNEDQKMGNTDEEGQEEEEEESEEEEEEEEPVNKRQTLIFSATFNKNLQQKLAGKSKFKATSTQDMEYLLQKLNFRETPKFVDANPVHQMAENLKEGLIMCGDMEKDLYLYATLMLQPTRRALVFTNSVNSVRRLTPLLENLNLPAFPLHSGMIQQARLRSIDRFKANEGAKKKNGSAAILVATDVAARGLDIPEVDLVIHYHVPRAAEDYVHRSGRTARASNSGTSILLCGPKEAVPTQRLVAKVHAQAEVKAGNSGNNTKKLVSSGLRTIDIDRRVVAKLRERVDLAKKIADAVQAKTMGGKEDDWMKKAAEDLGVEYDSEELEKAGKWGGKGSFKKQKQKEAQQMSKGELASLRAALRDLLSKRINTGVSERYLTGLDVSELLKGEQGLFLGQVDGLGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQZ0</accession>
    <name>A0AAE0MQZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_233035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680691.1">
        <property type="nucleotide sequence ID" value="XM_062822216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQZ0"/>
    <dbReference type="GeneID" id="87859370"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="311"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="600" mass="67485" checksum="E2821D62B54A91E4" modified="2024-05-29" version="1">MELVVQLHHRASAPLWSMMSEFCLAPFWYKKIYNPKHDAKDLFCVPRPLKIIDQHQKMSTPVAYSHLCSECSEKLRFPGSSLPAAPVDSPGNDAEDHEAGIEQEDDEDEDCKLLEYTLRGHRVDCDYTIIESYPDLALLTARSSECKFCRLLRQSLTSKEFRILVEDQTFSHVAPLDLWISLSYAWDFKYTGNEDDREVGLWFLTADLYENSQLNGHHLGSISFPLSTASESITNFYGMGPSIYRDPFSERSLSFILRELECCSSSCTHPQPSSNFLPTRLIAITNDSDECRIIHSRDLPSSTFRKSGTRYLALTYCWGNAEEASQQKKLTPSNASSLYNPGFSIADLTPIQQDTIKLAKSLSISFVWIDALCILQGDSKDWERESAQMDDIYSNAFFTVCSLTSWSCLEGFTSAEEKTSVPVAFRSAFDPDIHGEIAINGNFVVGKDVLNPERFSGVDISQSQWIRRVWTFQELALSPRFVHFGGSGVGFQCKSKAMYDWGGLKGSPNRMIGLGLNAAAGGEDDDTQNSHGNQDFWNRTVLAAYSQRKISYASDIFPALSGLAKRASKAIKSKYVAGMWRRDLPYALMWTKERPEATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR09</accession>
    <name>A0AAE0MR09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_510823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679685.1">
        <property type="nucleotide sequence ID" value="XM_062828436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR09"/>
    <dbReference type="GeneID" id="87865590"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3340743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="124" mass="12952" checksum="551B7EE8BF810129" modified="2024-05-29" version="1">MVCAKCQKKEKTTLITPGVKKKSEMYYGSPAAASSSSSSASGPKKSATLGNTGVVKSKLLSKAAQNPYAQYSSTCTRCKAKVSQGHSFCNKCAYRANSCAICGKPNKNTTAGAPLVNGQKFTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR81</accession>
    <name>A0AAE0MR81_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_241510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680946.1">
        <property type="nucleotide sequence ID" value="XM_062822329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR81"/>
    <dbReference type="GeneID" id="87859483"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="303" mass="34902" checksum="F338F11DD95F8F2F" modified="2024-05-29" version="1">MRLLHTISLNLVEFIEDIPRARYAILSHTWGEDEVSFRDLTYDIERSKKGWRKITNACEYAASRGWEYIWIDTCCIDKSDPTELSLAINSMFRWYEASGVCYAYLSDVMSPATVSNRSRVSWFRADEFDAFSRSRWFRRGWTLQELLAPDVLEFLYEDWTPIASREDMASEMQKGTGITSDHLANFRMCSLATKLSWAANRETTRVEDRSYSLLGLLGVHMPLIYGEGENAFVRLQHELIRKYNDESIFVWDGEIGTERGVPVGELRSGSCLFPVLTSNPQRVADESLSPTTLRIRSKILQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRI4</accession>
    <name>A0AAE0MRI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RXT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_238993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680854.1">
        <property type="nucleotide sequence ID" value="XM_062822291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRI4"/>
    <dbReference type="GeneID" id="87859445"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="135" mass="15459" checksum="7EB5CE7EAF86FD2B" modified="2024-05-29" version="1">MSTQQQAMIMDTIVSIRKTLKRKAYESDSDSSIDHNTNRGYKLKKRARFVKQGRLANSNGPAAYKECYQVAEHAGYQRAIINQNPPLIDEDGYDIDSDDNEERVQEAISATMEENPYASILLEREWTQYVLCSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRN5</accession>
    <name>A0AAE0MRN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_468646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680360.1">
        <property type="nucleotide sequence ID" value="XM_062826969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRN5"/>
    <dbReference type="GeneID" id="87864123"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="128" mass="14586" checksum="46286CA1BEEF51BC" modified="2024-05-29" version="1">MSLMILLFQPLGGGGELLYTQLPPSHLPLPSPPFSSFFSSSLSSPPIIVLPFFQVVSAEKFPLHIRKPASRVNMFRVATYHQTFSPQTEWERCRTMAWPGLFTVSDDLQLGWNEHPSFYFYHLSLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS64</accession>
    <name>A0AAE0MS64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_428551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680870.1">
        <property type="nucleotide sequence ID" value="XM_062824772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS64"/>
    <dbReference type="GeneID" id="87861926"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3343077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="391" mass="42333" checksum="47095BD66EFB4B72" modified="2024-05-29" version="1">MHKQVTTSLLRRSYSTSSSSSSSSSRWSLLSRSSRISSNSNAALLLKTTPLQQLHQPQLQLQPQRVYQHQHVQTRQSSHSPMGLPPTNPRKKVTLNTLQSMYKRGEKITMITAHDFPSAHVAEHAGMDMILVGDSLAMVALGMEDTSEVLVEEMLLHCRSVARASSRAFTVGDMPMGSYEISPQQALSTAIRFIKEGRMSAVKLEGGAEMAPTIRAITTAGIPVLAHIGLTPQRQNALGGFRVQGKSKESAKRLLRDALAVQEAGAFAMVVEAVPQEVASFITGLLKVPTIGIGAGSGTSGQVLVQADMTGNFPPGRFLPKFVKKYGDVWGEALRAIESYRDEVKGKSYPAEEHTYPMAREEVEAFVGDVRRLMGANASASEAEGEGEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSF9</accession>
    <name>A0AAE0MSF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_442089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681185.1">
        <property type="nucleotide sequence ID" value="XM_062825561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSF9"/>
    <dbReference type="GeneID" id="87862715"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="122" mass="13083" checksum="073B71950946C1CA" modified="2024-05-29" version="1">MAIFGTVAGAIDISFKLSHLGQTLTAFPRPHTQNLKMAASETSITIMINDLGNLDKLTLKIQVGHKSNWSNEAVRCTLRSKFMCDLALALKAIPINGPPSFFFGIMAGPAMIMAIAGTITHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTF4</accession>
    <name>A0AAE0MTF4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_209236</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682175.1">
        <property type="nucleotide sequence ID" value="XM_062821907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTF4"/>
    <dbReference type="GeneID" id="87859061"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3345562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="360" mass="39040" checksum="E37BFA24E062340F" modified="2024-05-29" version="1">MSGTDYKFEGWLGFDKSSAQGNMVWGEFEPKPWEETDIDIKIECCGVCGSDIHTLRSGWGPTNYPCCVGHEVVGTVVRAGSQVEGDIKVGDRVGVGAQSDSCRNRTAKECKICADGKYNYCRVHYVGTYNGVYLNGGKSYGGYATYQRVPSFFAVKIPDEIPSSHAAPMLCGGVTTYVPLKFHGVGPGKRVGIIGLGGLGHFGVMWAKALGAEQVVVISRSSSKKADAMAMGATGFIATGEDPDWLAKNRSSLDVVLCTASSADMPFNEYLLLLDLDGTFIQVGAPDDDLPPIQQMALIFNRIKLTGSLIGSPQDIREMFQLVVEKNVQPWVKEIPMKDANQAILDLEAGKPRYRFVLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTJ3</accession>
    <name>A0AAE0MTJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Exonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_159794</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683014.1">
        <property type="nucleotide sequence ID" value="XM_062821217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTJ3"/>
    <dbReference type="GeneID" id="87858371"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="99"/>
        </location>
    </feature>
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            <end position="208"/>
        </location>
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            <begin position="414"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="546"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="757" mass="83792" checksum="A2B246D24BAC9500" modified="2024-05-29" version="1">MGINGLLPLLKSIHRPAELRKYAGETLGIDGYGWLHRGAIACAIDLAQGKPTRKYVDFAMHRVKMFKHFGVTPYVVFDGDYLPSKAKTELDRESRREASRKTGLELLKAGKPSQAHIELQKAIDVTPEMARHLIDELKKANVPYVVAPYEADAQLIYLERQGIISGIVSEDSDLLVFGAKRLLTKMDQYGQCIEINRSQFCAVREISLTGWTDAEFRQMAIFSGCDYLDSLPSMGLKTAHRMIRKLKTPERIVKKIQFDGKIRVPDDYLERFKQAELTFIYQRVFCPEKQAVVCLTEPDESINVDTMPYIGAPIDAKLARAIAVGDVNPITKERIIITATSPSKRRISQVFTSAYGEGKKMGKPIDQYFKDRRIPLGEMDPNCFNVEPDNGEQEATTEPRPIVFPLPRPYVEDVGTSAAPTRRYTTQNSRRKSEPISKLLASFDDTSSVTSRRQTTGAGFEVFTDTDPAISTRPPKKARLCADAVSEDAVTATPEKSKFFPQSKAKKAAARKSESFIMSDDSIEEAFRSVPDAVWSSSKARRRSGKVQFVEESSSSEPVSQEKEEQEFEEPSLPVMPVAAIDASSDAKDEVEVPGSSPQEAITKKTVKSQTPLGPRLRQFSYQPGKPGARIVDGLPTPSSTQERPAAMRRSSLNPSTPMLTPLQRMGARALKQVTPRATPPSSVRARKSSKPSESLGSLPVDPAAVPLPLVDFAEVRALNMPLQGSEDQIIPESDGEADLGTTATRPRLNLSQYLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTN6</accession>
    <name>A0AAE0MTN6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
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                <person name="Westerberg I."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="512" mass="54574" checksum="DBA7F5259C92A0AF" modified="2024-05-29" version="1">MPPKRGRPSNAQREAERSAAVSKGKAAASTSAAAQEPANTPNGSITVSVGGPSATTESRSPETAKTASMNAPRASASASKKGKDQAQTAANATAEEPNASSTPNAADATTNGTTPITTTSTTNTKESKLSGNGTPKKNTETALVVASDGNSDMNSKNSKNNDITALARGGAYTAASRVIGTGYENINNIEEIQLRQFHEDIDAYQHDLAFCTATLAMPDLTPQEARSFQLRQLDLGHQIRHCQHKIENLQVQLRRQGIPFTNYSASSGGRAYTASLLAGAGVAGVKRSDPSDDDDDGGKTTGSAKKAKLTPDEPQLLDADGDEVMTTGAGRERETGSPNGNSSSPQPLPYGTPGTWEYNIPLHPSHPSYQHQHQQNGNGANNSPPYDEENQQNTALQRLGYWKCRLCSAPKYLLAGTGRSPAAPCKWPLKDISKMITHFTEMHTEHSPAERCSELGYALAKNRGPFEYWLRRTRAQNVGDGEIIDEIIQGLINGVMPHQLRRLSRAASGMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTU6</accession>
    <name>A0AAE0MTU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_456300</name>
    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684198.1">
        <property type="nucleotide sequence ID" value="XM_062826284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTU6"/>
    <dbReference type="GeneID" id="87863438"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="81" mass="9206" checksum="ED8CE46E8C3490F1" modified="2024-05-29" version="1">MNLFPLPAMEKLWLRTLAFACFACLAFIPPRDLIKKKRGVNTIHSSSRDLMEGGIMYLPHLPSPRSSPMGIAWRLIKLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUA2</accession>
    <name>A0AAE0MUA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_98090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684051.1">
        <property type="nucleotide sequence ID" value="XM_062831648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUA2"/>
    <dbReference type="GeneID" id="87868802"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="716" mass="81070" checksum="F3B29D661DE94BDF" modified="2024-05-29" version="1">MSLLKLPYEMVSYVLDELDLDHVWQLSLTCRHLRSLVTESNIAKRLLESKAPAATETQNAHVTKNYAHELRRLMKRRQSISSVTPYLAAVVGFGEDWIYRDGVLCYIRHDQLRILNLHGSAVDEIVVNIRLLLDEAIPESRKIRNYRFRPLNVSNNIVSCLYYYKEPCTSGCDCGSVYAGSLVVFSAQDRKVLTARRLLQDFEPKRVAVRNNDKVLFLIHRSRYQEGRSICWNAYNILANAWHLSTRLRLFGFHFQPFEIGITHCFEILDGHIYSLSNHSDLEEEEGDWVSPYHCLRFPLAFNVVAKLGPDRLLRRNHLDGPMDHRWTFMRMFKDEATGEIKVVESRREWIKRSSSATRTYYTTTIKWPSESASHFVSDSNEDGSDGSNTSGNNFGGTSISPGYLGNSGNEPDHGNAEVHPEDGISGPGESESNHQRGDRPPRILPPRDPQTVHPGDDSSKGPIFLRNKCPILSYHPSCQTFLDLVDLSPSNSDKRRMRIRGGTRHRRRPEEIEDWSRSAKEKGSLSVAEKHFEEVYKMYKHEEPVSWPPDHDPKSPNPALAQLYEILSPPNYAGEITGDWDERSFVYAAGASCGSKEKALVFISFDPSISLAGTLPYPGPMMFGRPQSVDTTGPTTTVSDNSTAHQSHGDGVRRGRQLGRARQTPRGRQTVKKRQTGRNAPTEATQVHSTKADAAWCTIEPAQYQTIKKGFHFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUC0</accession>
    <name>A0AAE0MUC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mis12-Mtw1 protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_457710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684678.1">
        <property type="nucleotide sequence ID" value="XM_062826369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUC0"/>
    <dbReference type="GeneID" id="87863523"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="558" mass="61374" checksum="A49F2FB573EC1762" modified="2024-05-29" version="1">MTTVVRTRQPLQILSMSSNQRRSKRLAGKLQSILQFNAMMRLFGPRGDPDMKADMIPKRNAAEAVYDEQDGDFLFTRGSKRARTTSIAPASTLEEPENEAMPISVPAKKPVGRPPKNSARKRASSPVQEPPSPPPAAQQQQISGPIPRRTSKRKSNGATAAAPPAPAPSAAIPAGNEEDAAPKSRGRRKGRPPKQQKDDEAPRPVNGMRAVPEENEEDDDGPNLVGGTPMDIDDTRDVRTTNRKGAGRGSSSEPQQIVLPLSDTPIINRNKEMRKKGGASGSRRSSLGMRGRRASSLIENGHSAIPHREVDPSEFYKHIEAEGLSEPRRMRQLLTWCGERALSEKPPHGSHGSSAILGARAIQDQLLKDFGARSEFSDWFAREEAPKPPVVLQPNPRNLEHDAKIAELEAKIKRLKEEKKAWQALAKPLPDLEPLYPDPDPTKAPLPEPSLLDAEEAKILASLTESDTAFSSFRRRTRSRLQNVQSSLEFKIDHLADSVHKLDMRVSTAGREADRVLALSAARLKEREEREKGRMGTRDLPTIEVLRSLGRILPAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUM9</accession>
    <name>A0AAE0MUM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_130616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684978.1">
        <property type="nucleotide sequence ID" value="XM_062820797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857951"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1291"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1531"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1653" mass="183913" checksum="8BF1117E4259801C" modified="2024-05-29" version="1">MLRRLASVRHTNGHRTPDDQEPMSPSPGDDVPHPETTKSASGALASVFKGLAGGKLTKPPPPLQPPMATVTTVASQPSRDRSDALPVTSVLRGLPQQHMEHFARLKTGQLNDRIAAANALRYAITEFPLNPIMEVWNAAKDLIDGDNPENARVAGWRLLTECVKNTSATDFERREYFRTLTAQTAHLDDFHLQLEALEYLTNRGRNVAGFYYDIFPLLTVWLANTFDAARLARRANKSAKGKTLVTVEDQSFSRLFALIRDVIKFNFKYASDAVVGRLMDNLLEICNKTSQEDDLAACISVIDAMVTFGSIPNGKLKDCIQVLSSIHCLVPSRQKDAWHTLSNICRSHHGQSTVRILLDVLRNAPAAPDKERDRDVIRDIRGALTVLKKLLGKSAEKGYPGVPLALLVDGLANVCTSSSSRVSTEILRLVNSLFDDGDGIINPLIAEEHWSPIFSVAAQCAAKSVPAVLKDVDPSIPQPSAPKDDHESGDNINYQLRTFINRVEKLLTEEKPDFFQRDECMRFLAEVHRVLPDSAAALLLDHLKEFRSCYPSEVDWKKNLELVLEGIYLDRGRSAPTRIQALAMVIEIYDFLCLVRDLVEEESIFDLVKRVLSGMSVETDAVVLQETVTFMVRVAETAGAEQFDFILDTFKNIVCKEVDEPTPSTAVQKSSGTQQISDQPVEVGGPSLPNVVTKGYVRIFMRSMDVDASKAVKTFNTLIHIAGSTTCETDARLTAMKLLFRLRADFEYRVYVTPHVENESIAASLYRTDASFARKAAEDAAHPPRLGRLDQTGSPRPPIRGASYMPGQTVERSGPIRPLQQPRQIPYQGQRLWSLPDPEALPETPRSTPSHLLFSYTEGADGEASTEASNAVLKMSSWLNTLLNIFHQGSDWEIYSFIIAHLPAQLSDHPIFQDAIPQLQELRGHICEVIRTNRFQEPPLVSGLRRPDVANCLFHSLTMLVSYHQHFQKLDEDEIVRAFLHGIADKTAKTCIHGLSICCYELPLSVSKSLDMILTRMSQVITQPFVAMHLLEFLACLSRLPALYSNFRDEDYRVVFGICFRYLQYVRDKKHHARSTTHMSEPSTPNIVVSGSPDFLAQQAITDDLPQYVYALAYHVITFWFLAVKMPDRLGHISWIAKNLFTDVDGSASNEEQAQITLDFMQRVAFSDASDSAHDPLFNRENFGEIQQKRWIIGNSIVTVKQAKESGWAEITRRYPSGTSSYAVRVEFTPMTAQRAADSSDDAAWDGRFQMGTTLLPSHVFLQLLAPMPQMSDPAARPVPLPDEEAIDRAIRLFDRNSAVDGHKVGVIYIGEGQTDEVEILANTIGGPDYHEFLDGLGVLTRLKGANFNTQGLDREYGTDGEYTYCWRDRVSEIIFHVITQMPTDLERDPRCTAKKRHIGNDFVNIVFNDSGLPFKFDTFPSQFNYVYIVITPTPRHSFASARLMAKQREEEGRKASTPFYVVQVMSQPGFPEISPAAEPKVVSLTALPTFVRLLALNASVFSQIWATREVGEHVSSWRNRLREINRLRERYGTKSAQQQPNSSPPPNMLGGGGGGLGLSVTSPLASGGQGGITQQSLLGQDIGASRPVNAVRDSFTSLRRSSVATFFTNNSAADPTSHRSSMLSTTTPDTEVMFPAHGADALIESVDFSKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV14</accession>
    <name>A0AAE0MV14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">60S ribosomal subunit assembly/export protein LOC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_114936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient assembly and nuclear export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 66S pre-ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LOC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684634.1">
        <property type="nucleotide sequence ID" value="XM_062820639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV14"/>
    <dbReference type="GeneID" id="87857793"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037650">
        <property type="entry name" value="Loc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY/EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028:SF1">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY_EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23216" checksum="459EA2ABF9AB8C1F" modified="2024-05-29" version="1">MAPTKTIKNKHAANKSGIKGSKDAERSRNDGVLKSKGKPKSKTHTLVTANKGRPNIQELIARKQKKKKYSEKELAGMIPELNMITPVGVTKPKGKKKGKVFVDDKESMATILAIVQAEKEGQIESKMIKARQMEEIREARRAEADKKEAERKARLEETKDSLRKKRKRSKSQGGKGDDDDSRDVKEFSSAGTKAVKSKKKKSVSFAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV37</accession>
    <name>A0AAE0MV37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_419960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684694.1">
        <property type="nucleotide sequence ID" value="XM_062824247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV37"/>
    <dbReference type="GeneID" id="87861401"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="285" mass="31315" checksum="571DBF9DB2F60132" modified="2024-05-29" version="1" fragment="single">ALHTVIIKHVNQINDSIRVFRLAIPNQKTIQFSAGQWLDVYVPTVPKAGGFTVTSAPSVAVAQQGPDGQVPQAYLELAIQKSPDNPPAAWLWQPVPSIMNAEVKVRVGGSFVWPPAGIDVSSLRKVVLVAGGVGINPLISILTAIADDRKHGRLPESCEVTMLYSMKDPGPPRDVKKMLFLERITWLFAKGVVRGTFRLFLTRPFERNTVPNMEDGMVNCHGFGVKFASRRISLADLASAIGHDKDSAVVYVCGVPAMTDEMVEKLVSNDGLGMERDRVLFEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVJ3</accession>
    <name>A0AAE0MVJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_420661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685386.1">
        <property type="nucleotide sequence ID" value="XM_062824295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVJ3"/>
    <dbReference type="GeneID" id="87861449"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3352091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14299" checksum="63F2EAE932E4F0F8" modified="2024-05-29" version="1" fragment="single">MGLPHSIHCFRGSGACLCSAWRKLRPPGSDIFIRLSPSNAASNKYFDSLLIWNLVVDQYQTLDLTFDRDKLVAISGLAKMHSKFLNTQYLAGMWLANLPEQLLWHRDLSQAPRPYSEYVAPSWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVS0</accession>
    <name>A0AAE0MVS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_25098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686177.1">
        <property type="nucleotide sequence ID" value="XM_062822458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVS0"/>
    <dbReference type="GeneID" id="87859612"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="151"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3354799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="589" mass="64134" checksum="BCCCC2500079170C" modified="2024-05-29" version="1">MSTTNLMRAARPIRRAVAGPGASGGTWSIACRQRFTTSAVRSNISGESSGSSNGKARQTRWASTWPPVSGAFAIATTAGLLGWSLSEFRHNGFPGAMLMDSIYPAPDYASLHEMEQAIAEIRREIEGEDIISTDPDDLHAHGYSEWSSTNPEGLPVAVAYPRSTEQVSTVARICHKYRVPIIPYSGGSSLEGNFSAPYGGISVDFAFMDKIVQFNKADMDIVVQPSIGWQDLNEQLAKMESGLFFPIDPGPSAKIGGMIGTNCSGTNAVKYGTMKDWVINLTVVLADGSVIKTRRRPRKSSAGYNLNSLFVGSEGTLGLVTEATLKLAVVPEELSVAVVTFPTIRDAASAAAEVMQRGIPVAAMEIMDEVQMKVVNIGGATAPRVWKEMPTLFFKFAGTKAGVQENIDLVQRITKTNKGSNFEFAKDAREQKLLWSARKESLWSMLALRKEGEEVSILTPLVVTGSTDVAVPFSRLADIIEVSKKEMDDLGLFASILGHIGDGNFHESIIYNRQKKEERDKVEVCVKNMVKRALEMEGTCTGEHSIGWGKKESLLWEVGPDTLGVMKSIKLALDPKWIMNPGKIFDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW05</accession>
    <name>A0AAE0MW05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_413994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686343.1">
        <property type="nucleotide sequence ID" value="XM_062823881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW05"/>
    <dbReference type="GeneID" id="87861035"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="198" mass="21642" checksum="AF181295C582FA60" modified="2024-05-29" version="1">MSQPTNSGIITDKNGERVIPESKRADGSTRKAIKVRPGYRPPEDVEVYKNRTAEGFRQRGKGPVPGAEGLKEDKSDQQSSAAANKNAKRREARKKAKAAGETEGEDQKTAAEAAPAPKPEEVDPEAEREKKARNLKKKLRQAKELKDKKDGGESLLPEQIAKVIKINELIRELDALGFDSEGEPKIAKASSEAKEDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWB1</accession>
    <name>A0AAE0MWB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Carbamoyl-phosphate synthase L chain, ATP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_544556</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686673.1">
        <property type="nucleotide sequence ID" value="XM_062829301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWB1"/>
    <dbReference type="GeneID" id="87866455"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="13">
        <location>
            <begin position="52"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="168"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="664"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3355295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="743" mass="80674" checksum="79B91FC9D9D4A527" modified="2024-05-29" version="1">MRSIKRASRRLPASLRGAPTSAPGSGARFLSTTAPTPSTATTNGSTNTSVTPISSVLIANRGEIALRVARTAASMGIRTTTLYTDIDAASQHAKCTPYAISLGAPSAYLDGPRIVELAKKHGIQALHPGYGFLSENPAFAKACEEAGIVFVGPPAKAMTDMGDKARSKEIMNASGVPCVPGYHGSEQSVEQLKARAAEIKYPVLLKSVKGGGGKGMRIVRTADEFEAQLKSARAEARASFGEGGEVMLVEKYIVRPRHVEVQVFADRHGNCVALGERDCSIQRRHQKILEESPAPLLDDVTRKDLWDKARKAALAVDYVGAGTVEFILDKDTNEFYFMEMNTRLQVEHPVSEMVTGTDLVEWQFRVAAGEKLPLTQDEIEARILERGAAIEARIYAENPEKGFFPDSGTLVHLSKPQTNEDVRIDAGFVEGDTVSEAYDGMIAKLIVRGKDRETAIRKLELALREYEVVGLSTNIEFLKRLCNSQAFIEGDVETGFIDNWKQELFGAKPTSNDVFAQAALGLLGTQTQNAPAAHGQTLGFGEAATQNSRKFAFRVQDDASTEEGKIVEVEVTQLNNKLFNVSVRKEGDDKPQVFENIVSESTSTTAPTSSAKKTKLTTYFPLARVNTTLVQDPADNEKLTVFQLGHKTQLRLVSPGWFDKALGLKEVAASVVAPMPCKILRNEVEEGQSVEKGAPLVVIESMKMETVIRSPQSGVIKKLAHKEGDICKAGTVLVLFEETDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWC6</accession>
    <name>A0AAE0MWC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_420371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685235.1">
        <property type="nucleotide sequence ID" value="XM_062824272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWC6"/>
    <dbReference type="GeneID" id="87861426"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="198" mass="22605" checksum="CC2287AEE8FE0268" modified="2024-05-29" version="1">MKVFSNTETFNYSWEEVSTANWRKYCPWNEKSTHVIAVDTISRSVDPATGILRTERLITCRQAAPEWLKSMMGGGMDESQVFETSYVDPKTKTVTMVSTNITWSNLLNVQETVVYSPLNDHQTKFHQEAQITALAGGWQRIKNSIEDTLVKRFRENAAKGKEGFESVLAMSRRVFAEEREKEKMGLIREQAGNIRMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWY7</accession>
    <name>A0AAE0MWY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_414648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686796.1">
        <property type="nucleotide sequence ID" value="XM_062823930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWY7"/>
    <dbReference type="GeneID" id="87861084"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042108769" evidence="1">
        <location>
            <begin position="17"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="156" mass="17248" checksum="7E1BFD684135E5AE" modified="2024-05-29" version="1">MKSLLLLPALLGLAFAHPAPELDPRAAPQIAHFYFQAAATGYNLTVPADGNWYPTNNGLNVNIITALDFTVTQCEFATHQQVAFAYQLSGADPYPKEQFAVGPPQPIDRVRCHGYCLQIYQDCYKNGQFVGSCCNGFCAANKCRPYVYPQDIPWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX50</accession>
    <name>A0AAE0MX50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_439357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687586.1">
        <property type="nucleotide sequence ID" value="XM_062825411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX50"/>
    <dbReference type="GeneID" id="87862565"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="696" mass="76976" checksum="95B3FCCE66B19C0A" modified="2024-05-29" version="1">MGEVVTASTSEVDTALTNTSSASATPFTMSKPDKLAKIGIRVILDAAPDRPATLPLIQKLDYEHALDKADSLLPPLIPKLGALDPRWHWQDAFNSLGTDAKTIAQKINDEPTGEAVNAALDDFWERKFGQYDETPLEFRVQYVFEYSSSGPIDGHRGFFAGQVSVPGAAKFFESEAILRHMLQSFPQGALVIEPQWMDKVMQEDEKHKFIIGKEAEIKAATDKYFAEGGSLAKCGALLGATNAVRIQGVVAREIHGRKVYTMVVATTDQHALDGVNLWEAAYDPAHPDVVIFSNTLLGKHKLTFIMDWANNVLGKRLMTTTWKTVQLSIEAEAAGIPLEKYIADRHAAGDPRVSKIARSRYVFAGMDGVAFIPATIRKHLGTNLNIERTHCIILDARADGPVADKLLSLKPDTPESVFSEMNLRVEKQPQGFFVHRAPADPFLLMHFGAISVPPALGSAALNAARNPAEQLMDSTMVAKIREDVTEHINRPILTTLLEQRPASSAKMIENMRRDTAWTSVVDDYLLTEVTPDLEAQVRDVLKSDAQWSDIPDLLLEKAVLSAARETICLPLLAPQAYVEKITSLTVYETMKIAVPTPVTLENKVKALTQAADAMDSVVQGMKQQLGDIAKDSAEYKEKEKEIYEKEQKVKELTEDKVGVEQMSEEMKKGEEGFKDIDVSVKEMEKDPKKKIFEHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX52</accession>
    <name>A0AAE0MX52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_69343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687527.1">
        <property type="nucleotide sequence ID" value="XM_062831281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX52"/>
    <dbReference type="GeneID" id="87868435"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3356150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="225" mass="25554" checksum="9919A3AA5FEFB8B0" modified="2024-05-29" version="1">MRKHRIGKRSGPANVEPPVQTMFRFVEIHPSQGVKDGSMAPSPASGEWLAWWERRVHPKQRNPKKWKALFTSAPHVFSQTPCLWCSFLPPEIKFAGPKCIIKPIGIGSRSNWQDRGLLGLLSPRRASSVRRLFLPSQLVERDTGNSWLIPSDCNLSIFQSHFEKGLFNTQSTPCSPPHTQTHTLLTAGLNRVSRVQPHTTQQQQQQRLFTTTTHYTPENTKINNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXC2</accession>
    <name>A0AAE0MXC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_536364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687139.1">
        <property type="nucleotide sequence ID" value="XM_062829042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXC2"/>
    <dbReference type="GeneID" id="87866196"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="285" mass="31904" checksum="F910E6F5385197FC" modified="2024-05-29" version="1">MTEVPSQSSFSILQDVGEKVPFFGAESALNAFQHSLKTFWARRLIFHLGFPSGFDPSEGTSSLLYDKAGLIEERKHTLPPGMVLTFPHNSSPRDSSVSHVSPENERSSRTHHHAKNINSVIRQNAAEVASRADTRGRLGRTSSPRISEVRASKYNQTQDVPYHKNCYFDPTLLRGIKPCHSLVLASRLRNWDFGSLPSMRRKLRGSDETSGKAIKIHPDMLPSALCTVCPPPLRRSALEVLRAYFWPDLAFVRLGSLARFARWLATSYDGSEERKPAEVSTDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J048</accession>
    <name>A0AAE0J048_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_512714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676634.1">
        <property type="nucleotide sequence ID" value="XM_062828596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J048"/>
    <dbReference type="GeneID" id="87865750"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="78" mass="9147" checksum="6C08D52A0668C59A" modified="2024-05-29" version="1">MCYTFLEYKYCAQGARCRGGYGWVNRQGQSYAKSYAQFLRTRRCYNAERGHDCRQRRSLGPGSEIKTSEETCLACRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0L1</accession>
    <name>A0AAE0J0L1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_437292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676621.1">
        <property type="nucleotide sequence ID" value="XM_062825300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0L1"/>
    <dbReference type="GeneID" id="87862454"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3334455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="490" mass="53733" checksum="89F1286E7A6A1CA0" modified="2024-05-29" version="1">MSKRAADDESLAAPLKGGDRPEAMDVDKDHDMGDFEDDFEDEFESEDEIIEAGVDGRPDAEREAEEGAMDVDGGPDTFMVGRQQLEAGQTLTPDTTTYKMLHSLSTPWPCLSFDIIRDGLGENRNVYPATMYTVAGTQADSAQANDNALLVMKFSGLSKTLGEDGEDSDDEDSDDEDTDPILEHKSIPLNTTTNRIRSHQSPSQDPSRPPTTLTATMTESSQVLIHDITPHLASFDTPGMVVTPQQNKPVCTIRAHKTEGYGVDWSPLHPAGKLLTGDNDGLIYVTTRTDGGGFVTDTRPFRGHTGSVEEIQWSPSEANVFASASSDGTVRVWDVRSKSRSPALTMKISNYDVNVMSWCRQTSHLLATGADDGEWAVWDLRQWSSNPSAKPAPLANFNFHHEQITSIEWHPTDDSIVAVAAGDNTVTLWDLAVELDDEESRDTAGVSDVPPQLLFVHYQNMVKELHWHPQIPGALVATGEQFSVFRTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0W7</accession>
    <name>A0AAE0J0W7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_512558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677064.1">
        <property type="nucleotide sequence ID" value="XM_062828582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0W7"/>
    <dbReference type="GeneID" id="87865736"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="378" mass="44740" checksum="4F56C1FD309A8D16" modified="2024-05-29" version="1">MPPPPPPIRCDRNSTLSEIFQAVEQERVRPFAHQYYSPNYVEEYDWDKFNPKYFSGPEFKSLPLEEQFRRFPKGIVENVDNYLDSTALEKMLAYMGGRRDDRHVYWLVDHQREAWHVTKLFNSRLESKRSELERELGEEEVERIRRAMKAEKERKKAEARERRERKLRERQKELEKQRAEEQRKKLQEEDERKMRVAKEEEIRKQVEAEEVRVRQQLVEDLNKGALALRKDIAAFSASDESVTIGECEALIAQIGRFIRLFTRRLEAHVESQMGEVNWRVVRAAVEGVISVLELIYFEDVTQIQRNSHVDWKDPNVLSHVAMGGVREGWGSLLRNLLFETQIYRMVRKKDDIHERLRAVLVDMAGHGMSGAREMTSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0Z3</accession>
    <name>A0AAE0J0Z3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_336865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677065.1">
        <property type="nucleotide sequence ID" value="XM_062823580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0Z3"/>
    <dbReference type="GeneID" id="87860734"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="231"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="495" mass="58132" checksum="DA47B2845F775CD4" modified="2024-05-29" version="1">MEPGVCNVCRDIPASFWLTPERERRIQLPNIEDVEAEAEKGCSFCKILVLVKKAHTVKFEEMLRLPPQMYVKIRAPEHTLMNHVKLYVRFSESQSRPSYTYCRIFLYSCQKLLQDGRSSPDLGYSLKEVERTDIGSGNLTHDLAKPIEQLQNTETLKRIERVTHSSDAMEYNLELMRMWIEECERSHDELCRVAQDFLPTRLLDLKAFRDDIKLVHIRPNEFNDKDQLPSYLALSHCWRPPEKHPKMTMRANLAEHMDRVQFMTLPRTFQDAIKITRILGHRYLWIDSLCIIQDNEEDWAREASLMAKIYSKAYYTLAALSSRDSSQGLNLVRPKLLVDMVIYDNENKKYRLQIEDKMKPAWDSEYNGSFDDSPLWYRAWAFQEKELSTRIIYFGKQQLLWECLAGKASIKNYSKVQYPKWTRQCPRQSASNNDLHELWILLVLDYAKRNSTKDTDKLPAFSSIAQTYQRLVLAQSTLLEYGAHIYQKLCSGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6J2</accession>
    <name>A0AAE0J6J2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_306457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677322.1">
        <property type="nucleotide sequence ID" value="XM_062823220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6J2"/>
    <dbReference type="GeneID" id="87860374"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3337871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="237" mass="25310" checksum="E24CB3E1DF92414C" modified="2024-05-29" version="1">MDFAPYQAAPPEHGRTISPPDSTSSPRTSWDYGRRSSYSPGSGNKYQQRPAQVSPPPLLHPQPHRAWSGEGISRYQSPGATPGTANGIGSGIGFSNGSGSGGGGGGVGGGMGDYFNALGAREGMVSEFDTSLGLRLDYEACLAYLAVPPLGAILLLILERKSDFVRFHAWQSSLLFTAVFVLHLLISWSSFLSWVLFLADLALVGWLVVNAYRDADTLDRYEVPIFGPIASGILDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6X6</accession>
    <name>A0AAE0J6X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress protein DDR48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_310214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677460.1">
        <property type="nucleotide sequence ID" value="XM_062823285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6X6"/>
    <dbReference type="GeneID" id="87860439"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40629" checksum="50F6E4CBF0E4A146" modified="2024-05-29" version="1">MSYNNYGERDNEFGSQRGEFGSERENERRGERREDSSNYGSEDRENRRNEFGSSNYGSDENRRNEDRPQSSSYQSGDNSRNDYEKKESSYGSSNSYGSESRRNENESYGSEDNRRNDYEKESSSYGSGNKRDDDERKESSYGSSNSYGSENKRNDSSSNSYGSNNDNNNQSYKNDAGYKGDDDDKPSSYGSSDTYGSENKQSGYGSSSNNNSYGSDNKQNNSSSDGGLLGKLSGMAISGISGQNKNSNSNNNNQQQSSNNNSGGLMNAFNNMAGGGAKGEQNEDYLDKGIDCVQEKFLKQGPQDNESAVEQAKDNMIADAIRNGYKTATGNEFPIKDKDNNNNNNNNNNNGNNNGDNNLAGLGKKFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J714</accession>
    <name>A0AAE0J714_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_312323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677545.1">
        <property type="nucleotide sequence ID" value="XM_062823320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J714"/>
    <dbReference type="GeneID" id="87860474"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="248" mass="27395" checksum="B34C96895BD4AC34" modified="2024-05-29" version="1">MRNNDYQTSVLAGFIIRFLYAINKIIIDANNIVIDAIISMDSFLWPLWTALALSVDETFHNAPAFFSCSSNQKTTSTGPASQLSTIINKTLQWIEPFLLPTPTSQEDTTITEESLEFLESRIDYLHNFFDATIAAMTITNPRSPKRDPSTGPSFINSSTPVRHTPVRSQVDPVAKTCAPGRYSVVFYEHSSGNADHAKKVLMVWHMPHPMDNMMGEASGVAQAVQVAGNLQEVVLQNKAPRPPLPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7C1</accession>
    <name>A0AAE0J7C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_478299</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677714.1">
        <property type="nucleotide sequence ID" value="XM_062827474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7C1"/>
    <dbReference type="GeneID" id="87864628"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="89"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="287"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="497"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3338263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="690" mass="74824" checksum="CB33B39C5DB811DB" modified="2024-05-29" version="1">MLRSRQAARALKALTEAQQISQRTTLSASQRAAVLLTSRSVQTRNQSTAAAEASRPTPSQNFQPEPTPSNVQPLVGRKTDMDESFIGKTGGEIFHEMMLRHGVKHIFGYPGGAILPVFDAIYNSPHFDFVLPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVVTPMADALADGTPMVVFSGQVPTTAIGSDAFQEADVIGISRSCTKWNVMVKSVAELPRRINEAFEIATSGRPGPVLVDLPKDITAGILRRAIPTDTAIPTIPSAASRAAIELSRKQLDASIHRVAKLINIAKKPVIYAGHGVVQSKGGPELLRALSEKASIPVTTTLHGLGAFDELDEKSLHMLGMHGAAYANMAIQQADLIICLGGRFDDRVTLNLNKFAPAAKAAAAEGRGGIVHFEILPKNINKVVQATEAVEGDVATNIELLIPQVEAKTMADRKEWFGKINEWKTKWPLSDYERAERTGLIKPQTLIEELSKLVEGRKDNTYIATGVGQHQMWTAQHFRWRHPRTMITSGGLGTMGYGLPAAIGAKVAKPDALVIDIDGDASFGMTLTELSTAAQFNIGVKVIVLNNEEQGMVTQWQNLFYDDRYSHTHQKNPDFIKLADAMGVQAKRIIKPDEVVEGLKWLINSEGPALLEVVTDKKVPVLPMVPAGAGLDEFITFDQERDRKRRELMVKRTGGVHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7G7</accession>
    <name>A0AAE0J7G7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H65DRAFT_478574</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677783.1">
        <property type="nucleotide sequence ID" value="XM_062827489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7G7"/>
    <dbReference type="GeneID" id="87864643"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="543"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="485"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3338332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="780" mass="84941" checksum="D71D9313751DBCAC" modified="2024-05-29" version="1">MPSAESTPRTLYDKVFQAHIVDEKLDGTILLYIDRHLVHEVTSPQAFEGLENAGRQVRRPDCTLATTDHNVPTTSRKTLKDIGSFIKEDDSRTQCVTLEENVKKFGITYFGLSDKRQGIVHVIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLITKRSKNMRVQVDGELAPGVSSKDVILHVIGQIGTAGGTGAVIEFCGSVIRSLSMEARMSICNMSIEGGARAGMVAPDDITFEYLKGRPLAPKYGSEEWDKAVAYWKSLASDPDAKYDIDVFIDGKDIIPTVTWGTSPEDVVPITGVVPDPETFATEGKKVAGRRMIEYMGLVPGTRMEDIEVDKVFIGSCTNSRIEDLRAAAQVVKGKKIAANIKRALIVPGSGLVKDQAEAEGLDKIFQEAGFEWREAGCSMCLGMNPDILSPKERCASTSNRNFEGRQGAQGRTHLMSPVMAAAAAIVGKLADVRKLTEYKSSPHVEAAVTPETATATAKAHADESIEEDDTQKDKLTDQPQDSSPQVNTSVSKSSAGLPKFTSLKGIAAPMEKANIDTDAIIPKNFLKTIKRTGLGSALFYEMRYNPDGTENTQFVLNREPYRSAKIIVCTGANFGCGSSREHAPWALNDFGVKSVIAPSFADIFFNNSFKNGMLPIPMKDQAALERVHAEAVAGREIEIDLPNQLIKDAEGNTICEFEVEEFRKHCLVNGLDDIGLTMQMEDKITEYEARMSQQTPWLDGRAYLKRKGQGGKLVAKAVPVPKTNRGEEKKEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J834</accession>
    <name>A0AAE0J834_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_281173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678070.1">
        <property type="nucleotide sequence ID" value="XM_062822879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J834"/>
    <dbReference type="GeneID" id="87860033"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF10">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042154546" evidence="3">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="227" mass="23188" checksum="50114E742C84D946" modified="2024-05-29" version="1">MKFPTLSLLLTGLAAAGPLTSRQSYSCPKVHIFGARETTAPQGYGTSAGLVNSIASACPGSTKEAIVYPACGGQSSCGGVSYDNSASQGTAAVVKAVTNLNQRCPDTKIVLVGYSQGGQIMDNALCGGAGATLTGNALRAVKAAIFMGDPHNVVGLPYNVGTCKAKGFAARPSGFKCSPASPSIIQSYCDSTDPYCCNGNDANSHQQYVNKYGQQALAFVKKLVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J842</accession>
    <name>A0AAE0J842_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5'-Nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_474530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678084.1">
        <property type="nucleotide sequence ID" value="XM_062827248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J842"/>
    <dbReference type="GeneID" id="87864402"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="226"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3338724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="606" mass="66875" checksum="BB457495AC9A790D" modified="2024-05-29" version="1">MVPILNKIGTQCACVGNHDLDFGVLQFQHLTSKCAFPWLLANVLDPALGENVPIGNAGRTHMITTSNGLKIGLLGLGEREWLETINALPPNLIYRSATEVAKELVPQLRAQGADLIVALTHMREPNDHKLARQMEGEIDIILGGHDHFYAHSLINGTHVLRSGSDFKNLSYLEVRRPASPPQPGQPKWDVDIWRRDIYSSIPRDPATDQLVHKLTSKLKKSLEKPIGFSAAPLDARFTTVRLRESNIGNFVCDIMRLHYHADIAIMAAGTIRGDQIYPPGPIRVKDVTDCFPFEDPVVVIKVKGQAVWEALENGVSLYPALEGRFPQVSNIKFIFNPSLPSGQRVTNVEVGGEPIDLEKTYTMSTRGYMARGKDGYTSLLVKSEGGECEEVVSEENGILISMMLRQYFMALKALDKWAFWGAEEDRHWGTVVKGVDEGREPPSSKSLTSTLEPKTGDGCDKETCVIDAEAKKDEQEEPTPAGQDGAGSSKPLSNWTFWTPAKLRERRATVKPLKESQTAVGDTSASGSSDSESGSSRPSSRVRGKAEDVRQIDRELRIMRRVARKWCRLAGVQSKACDCLDEGEFDVPWTKAVAPRVEGRIVEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8K0</accession>
    <name>A0AAE0J8K0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_511269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678354.1">
        <property type="nucleotide sequence ID" value="XM_062828472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8K0"/>
    <dbReference type="GeneID" id="87865626"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="354" mass="36466" checksum="353C6FDE19073695" modified="2024-05-29" version="1">MSAQVNKVTVKLTPSLLPLGVHHTQPTVPSTTTTKPDDTGSASASAPVSMADVAATTTESKPTAATDNLKPATDAHPDDKKDAEKPKTFPTEDEVVAAKMALEPVHAGSEFHGFETVTPSAPTHAIFDPAPEQDLVHENPRSDAVPTGDGLPDDIEDIENALADDPAGAGTVLPNGEAAPDVEKAAKEESTEGKVEKKVNEAKEAAATNPGQPVAAAPLGENGTNEVAGAAKKDEEGDTEMKNIPSETIAKASDPTQAKEGVKAAPAPAAAAGKKRKAEEYDEDDDNEAVNGQAKKAKTEQTNGDGAADGATSPVKRAPGRPKKTAADKVNKAARKILRPVGMTQRKTRSQGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8K4</accession>
    <name>A0AAE0J8K4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_324757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677951.1">
        <property type="nucleotide sequence ID" value="XM_062823453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8K4"/>
    <dbReference type="GeneID" id="87860607"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="48"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3338500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="629" mass="69787" checksum="31384C68FB2C8517" modified="2024-05-29" version="1">MADNDIKTMAEKTIIADLITQGIPTFTPSGPKASEYERSVATANLLYRFTRPACVVQPETREQVAQVIKKAKKLRVPVTIKCGGHSYAGFSTTNEGILLDLVRMNKVDLDVDNNLVTLQGGALWGHAYKALVNGRHNGIIINGGRCPTVGVGGFLLGGGLGPFTRSFGMGCDTLKEATLVTADGRIVTVSDENKANSDEGKLFWALRGAGGGNFGVVVEFKMYLSHLQNEEGLVVAGRYTWFPNPAVEGAMDEFTRTMEQFYTTSWPDSITINSSWLCDLKQQTSSELKLGVRFLVYYDGTKSDFDALISDKVQQKDLAKQLKRRTLAEKSTRFLHETLASQWSEETIKAFPSGTETAHKLYSSFVFKNDASRIKSVISIIRQEMAAFRREFAGESGLLQVTWIHSGGKASAKKRSETAFRWRDCTYHAYIMLEWQEKWLEMDMRGFLQKFKEKLRPFSMMGCAAFINFPDAALQSNASERVYYGNNRQKLQRVKQIWDKDNFFQWNQGVRLPQPEANKTANSMSAKAATFNAKAAPMSLISGEGLLSTSSFGWMSESNSVSPQPSLLNDDGEDGSLGDEGEMVDIDEQMLTDVYASEQWDSFDHPAASGKINYSALGRGIIDLSNLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J909</accession>
    <name>A0AAE0J909_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Necrosis-inducing factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_433889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678495.1">
        <property type="nucleotide sequence ID" value="XM_062825097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J909"/>
    <dbReference type="GeneID" id="87862251"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041982783" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="209" mass="22198" checksum="D0BC1024AF133358" modified="2024-05-29" version="1">MRASTILFGLTATIFASAAVIPKEAATVKTAVSPDGYVYNVETEAYIEDTITTADGITHTVLVHPAFKRSVDEHGTSHNPNKSKRLQYTAGGADQCDHSTLVNKTSGASPTTGDCGAVRDYYRRDNGHFEASALLDLLGSEWCRLVITGTCVFGIKSMNVGGTKVGSSNIADLVEVSINTYQSGGRIGAEGVTTCTGWRATTQWAIFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9H4</accession>
    <name>A0AAE0J9H4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_511647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678805.1">
        <property type="nucleotide sequence ID" value="XM_062828503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9H4"/>
    <dbReference type="GeneID" id="87865657"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="740" mass="82859" checksum="7C63758217B062D9" modified="2024-05-29" version="1">MERYVASARVSDSSQSPPPSATIPFSRDPDFVNRGDILDQIDQRCSEPAARVALVGLGGVGKSQLAIEFAHRTAARHPDTWVFWVHAGTQARVDEGFRAIADAAELPGRNDSKANIPQLVYGWLGNERNGKWVMVLDSADDRDVFFDAGSNPERPDYLPQSPNGSLLVTTRDKDLASKLNTIEIGPMAQSDALLLLEKKLGSLSDTDMAVDLVRALDLVPLAISQAAAYIQRMSPRSSPKKYLDEFRESERNRRKLLQYDGGDLRRDGGASNAILTTWQISFDHIRSKRPSAANLLSLMSFFDRQGIPGWVLNPSRIAQDGMQAIGLDDAADVESDDSSQSTDSDSDDASFEDDAAMLRDYCLITADETEDKFEMHGLVQLSTRRWLEMFGQEETFRQQYIERMAASFPTGQFENWAMCRTLFAHARVASDYRPSENTVESWAILLHNGGWYAWSQGRYEDAQQMLGKARKRRLGKDDVATLSSTSLLALVFRDRGLWKEAEKLFVQTSKAKLGADHPDTLTSMANLASTFWNQGRWDEAEKLFVQMSKAKLGADHPDTLKSMGNLAFTQGRHEDALALMQDCVETRQRVLGPEHPDTLSSLATVSEWYHGARRRVGDRLDMRSWLSHAQSQTHTRPTGSTRLDRPWRESCIWDGRLERARDLAEKLEVQVMETRKAKLGADHPDALTSMANLAFTWNSQGRHEDALALMQDCVEARQRVLGPEHPDTLSCLATVSEWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9S7</accession>
    <name>A0AAE0J9S7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_511503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678628.1">
        <property type="nucleotide sequence ID" value="XM_062828489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9S7"/>
    <dbReference type="GeneID" id="87865643"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="302"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3339268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="613" mass="69714" checksum="A0C4E56C62370616" modified="2024-05-29" version="1">MHIREMLADAERTKAPSFSFEYFPPKTAQGVQNLYDRMDRMYNFGPKFIDITWGAGGRIAELTCEMVAQAQAYLGLETCMHLTCTDMGEEKVNNALQRAYKAGCTNILALRGDPPREKEKWEAAEGGFQYARDLVAHIRKLYGDHFDIGVAGYPEGCDDNKDEESLLDHLKEKVDMGASFIVTQMFYDVDNFLRWVKRVRERGITIPIIPGIMPIATYASFIRRANHMNCKIPEEWMAKLEPVKNDDVAVREIGKTLVAEMCRKIVDAGIHHLHFYTMNLAQATRMVLEELDWLPSPNRPLKRALPWKQSLGSGRRDEDVRPIFWRNRNKSYITRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGSNELNRKKWGEPQTVKDIANLFVRYLNQELEYLPWSEAPISSEAELIKDDLIALNNRGLITINSQPAVNGVKSTHPVHGWGPANGYVYQKAYLELLVSPELFPEIKRRIEDHPDITYYAVTKSGNLHTNAPSEGPNAVTWGVFPGKEIVQPTIVESISFLAWKDEAFQLGLEWARCYDADTPSRLLIEEVMNKWYLVNIVNNDFHQPRTIFEILADLSVSDLEKVYTPTQTNGATNGVSEASTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA52</accession>
    <name>A0AAE0JA52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_580916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678841.1">
        <property type="nucleotide sequence ID" value="XM_062830802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA52"/>
    <dbReference type="GeneID" id="87867956"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF5">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041908379" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="333" mass="36661" checksum="8A81299CB9F15BB2" modified="2024-05-29" version="1">MKWLSITLALAGPSQAALRFGCSTLSIQRLDPLVEPGRLPSSHVHQIVGGNAFNVSMTGDIGQQGSCTTCTFSEDFSNYWTAVMFFKHANGTYKRVPIMQNAALPNGINGGMTIYYTQQDFNSNGNQKITAFKPGFRMTVGSPTTNSLNDAKGHAGLRFVCLTDKNTRFPELPNFPTKPCKGGIMTVHHFPSCWDGKNLDSPDHQSHMYNTAKEAFSPAGPCPASHPVRMPQVAYETLWDTTQFNNMWPKDGSNPFVLSYGDNKGYGTHADYVFGWKGDSLQKAMDSSCMFNACENGRPLKSQNVQAMNKCAVRNMVNEDLDSWLKVLPGQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAD9</accession>
    <name>A0AAE0JAD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_296773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678682.1">
        <property type="nucleotide sequence ID" value="XM_062823092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAD9"/>
    <dbReference type="GeneID" id="87860246"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="755" mass="83202" checksum="37AF122D57F9E6AF" modified="2024-05-29" version="1">MADAMADAMAIDGPRGEKRKASVFDDDSGHAPRRIRPLDPDVVNKIAAGEIIVAPVHALKELMENAVDAGSTSLEIVVKDGGLKLLQITDNGCGIDKQDLPILCERFTTSKLQKFEDLQSISTYGFRGEALASISHIAHLTVTTKTHESNCAWRAHYGSGKLVPAKPGQSPDPKPVAGRQGTQITVEDLFYNIPTRRRAFRSTSDEYNKIIDMVGRYAVHCSHVAFSCKKHGESSTSIAIQANASSTDRIRQIYGGSVANELIEYSTSDDRWGFKAKGLATNANYNLKKTTLLLFINHRCVESSNIRKAVEQTYTSFLPKNGHPFVYLSLEIAPERVDVNVHPTKREVNFLNEHEIIQAICEHIRSKLAAVDTSRTFLTQTLLPGGTWSASDQQASSSTPSKTSGAASGARKTPARNESSLVRTDANMRKITSMLPPASTMGAGVRGDGISSTSGVKATITGTNKDVEMINYETVEREATACRLISVRELRAEVREEMHHELTEIFANHTFVGIVDERRRLAAIQGGVKLYLVDYGRVCYEYFYQLGLTDFGNFGTIRFDSPLDLRELLSMAAEFERSATADASGGVDKDGDGEMDVSEIVELVADQLVERREMLLEYFSFEISPAGELLSIPLLVKGYTPSMAKLPRFLLELGPRVDWSEEKACFEGFLKELAMFYVPERLPATIGADDPPAVQGGDKDVDAETVARRDHVRFALEHVLFPAFKSRLVATKSLMQTGILEVANLKGLYRVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAR2</accession>
    <name>A0AAE0JAR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_590637</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679440.1">
        <property type="nucleotide sequence ID" value="XM_062831073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAR2"/>
    <dbReference type="GeneID" id="87868227"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="13">
        <location>
            <begin position="104"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="14">
        <location>
            <begin position="342"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3340498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114862" checksum="91A81FE60C83270B" modified="2024-05-29" version="1">MDAQFEKAIEIAFDPRSSQALKNQALEFLNQVRTDVQAWRICAALFTRSPRASDIVRHVSLEMVNNAVHSQGLDAPDLAFVRNSLLDYITRTYGPNAQDQADPANVQNKLTQTLTYLFVALYGEGWETFFDDFLALTSSQNGTSRDNLSGVMLYLRILSSVHDEIADLMISRQGNESKRNNDLKDLIRERHMQKIAMSWQDILAQWTNKHDGVVELTLKVIGKWVSWIDISLVVSQDMQSLILPLVGRANNTSNNIDTVRDTAIDTLTEIVAKKMGPSHKMELISFLNLGGIITELLASQGLNEFKGTSRYDNDLAEVVAKLLNTIMTDVVRVLEDNKVDAETRAKAERHLQDFLPALLRLFSDEFDEVCSTVIPSLTDLLTFLRRVGTLPDSYSHMLRPILSAIVAKMRYDETSSWGTEDAESDEAEFQELRKRLQILQKSVAAVDQTLYIEFLSNLVGNMFATLEQQGPQMDWRDLDLALHEIYLFGELALPNAGLAHKSEPNAVATERLAVMMSKMVESGIANFPHPAILLQYMEICVRYHAFFESHHQYIAPVLENFVHLIHHEHPRVRTRSWYLFLRFVKQLRAQVGNVAKTVIQSISDLLPIKAEVPSTEAEDDMSSDESDHSADAIFNGQLYLFEAIGCISSTSTTPEADQALYARSVMEPLFTDMSVHLPRAKSGDAQAILQIHHIIMALGTLANGFADPNQSQNPNNQRTPPQAVSAEFSRASEAILVALNELNTNGEIRAACRSAFSRLLGVLGATILPQLPQWIEGLLSQSSSKDEMAFFLRLLEQIVYNFKSEIYNILDLLLTPLLQRVFAGLSEPINGTDDEIQLQELRREYVSFVQVILINELGGVLVSTSNQGVFESLVNSIMTIAKTIVHGNIVASRISFNVLARMAQQWGGPDVATIGENPTANGVPAPAFPGFDQFMLTQFHAACWEVMQDINFRPYADAQTRQILNEITGLEQTIYLKTGEKFINHCQTVTFPAVGMGAEDFLRALTSSTDRKAVMVYLQQLLKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAR8</accession>
    <name>A0AAE0JAR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Docking domain of Afi1 for Arf3 in vesicle trafficking-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_263064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679480.1">
        <property type="nucleotide sequence ID" value="XM_062822642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAR8"/>
    <dbReference type="GeneID" id="87859796"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="119"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="853" mass="96364" checksum="8F06D240053927DF" modified="2024-05-29" version="1">MASPQPARPSFSRNNSHGATGTAHDRKPSLSSFPPQSRSVSQMSHHGPARSPQPPHAEPDRTSNQSSKGKTASTGTGFSSQHSSLSAAGVTRQYNNAIGHPRRKLRSQYPRGSTENHVEYILVASFDIDRGPVMEHQYPVAITGDEHMLAELMLPDQAHARNQDWTIFFLHKDSSREEDEAERQAKEERRRRRKRRLDREQGIIHESDDEDDDLDDDDWDDDESTDDDEPEGGEGPPLVYVLNLVNTKHDKTVKRGAVVKAMAICTRHPFLHIYKPLLLLALEEYFKSPVPETLSMLFDAVNEMDLSLMPKLSLLERHLLQMSNNKDLFVEKFEQMIQMRISGDRDGLADQPFDASRSPPRRPGIFRHGTKAHLVGQSTYAVPRDTHEFESRVMYKGIPIPIKVPTAIMPETVGDFSLIKLIQNFSEPHAKSPHPFPLHAHLTTNGPNTHPIIVLVNGLLTQKRVIFLGHNMPSGEVAEAVLAACALASGGILRGFTRHAFPYTDLTKVDDLLRVPGFIAGVTNPTFEHHPEWWDILCDLPSGRIKISSRIEQPAITEGLVYFQQQNPSCASLVHQSHSSSAADLTGDQAFMADMLKSIATRAGERVIRAKWRDWVLKFTRVAAAFEESVYGASALYIGSDEHDNYPHTTNSTGHGYVWADDEKKSKELAGNVTRIEGWRNTRSYYSFIQVRGHLFSPLSFLFQFRDVAQLYTVRPLKGLDLHHMHDRLRTQRLTAMQSRDIYLTFAKYVRNYDEICLLLSVAPEAHAGLFYIALGLFHKDREVRVKTADLLERISQHEAGQHWWRGLSRFEKLAYDRIKKEVQMAEAQAGMQGLTIMPGSSEDPMRRISREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC55</accession>
    <name>A0AAE0JC55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TFIID-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_509554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680245.1">
        <property type="nucleotide sequence ID" value="XM_062828326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC55"/>
    <dbReference type="GeneID" id="87865480"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3342452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="257" mass="27521" checksum="7886CB369988E50B" modified="2024-05-29" version="1">MEAIQTHPSNAAQAKAFTAPGSLSFPGAAGELTPPTSTANSDKGAAVNGAAGAQAANGNGVTPATPAATPAANQGPTSGMTPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASKHHNFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEMIYPVLQDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCB7</accession>
    <name>A0AAE0JCB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_219132</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680228.1">
        <property type="nucleotide sequence ID" value="XM_062822027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCB7"/>
    <dbReference type="GeneID" id="87859181"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3342435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="105" mass="11676" checksum="5E1FA5D03183C366" modified="2024-05-29" version="1">MPAPILRAGALVASRRAFSTTRAVRSGGAPHYDPPSGWLFGVRPGEKYEREGWEIPFFYGFCGSFAVATIAYAFKPDTSIQTWALEEARRRLEAEGILEDPQPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCS2</accession>
    <name>A0AAE0JCS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_469357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680590.1">
        <property type="nucleotide sequence ID" value="XM_062827005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCS2"/>
    <dbReference type="GeneID" id="87864159"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="72351" checksum="8854CDC9FF8C70E2" modified="2024-05-29" version="1">MPGWTLALRLRRITAASPVFPRQTFHKRFYSSSTFQPSIERYTVPCASAGEITVSLYNVADRPPTDPLIIWIPPFAARDENDPNYHLPSWLHKFSVAVIHYRWSGLYDERPKPKPKPKPKAEEPDFDDEGYHSSETPDRKEEEELSEEEENISITPLHWPTPIHDVLFGYSWITQNLQPRFPQRKDVYICGSYLGASLAAGLAFSESYPHARMAVRGLLAYNGIYDWTTFLPDHPIHRPKGDDRILIEEKLHKLNRDLDKDGGPAATSPIIAHYQRRLEDLFGSPSGLFDSFASACLFFHTAGLFIPTTFDEKYVPEWLHPPPPGPLITGAGVKGVSSDVAVNVPSDPHDPFSPSPYTPPSTPPPQQPPPPLPASQNPTDDLDPDSEHSEKYRMQMSMVNDAEGEPDEVAAEDMLQQILQVEILSGKFPRKSYVHFPPRHSMLKLPDTLLLYETPSAELPFKCDALAKIGSDGSGARALSTPPTRSQKTKQQQKKEEKEEKDAEEDDEAEAEEDGKTKEKKSSRPQPRPRLKTRKHRKPPVAITAGENSFRTQAYELALLMQRSIETLELKERRKWDDDYLVDLHHWELEAARRVKVADVGVVDDQDMEIGDLEGVGDLDERGREIVLGWLEEKMDKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCU1</accession>
    <name>A0AAE0JCU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_540276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680453.1">
        <property type="nucleotide sequence ID" value="XM_062829149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCU1"/>
    <dbReference type="GeneID" id="87866303"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="638" mass="69867" checksum="791DB48F727658E5" modified="2024-05-29" version="1">MARADGLTPPGYDTSTEHTLPGRDSITTTRQFVLTTPQVTSPSDITVSQDTCAVHTCPVENHHQPSQTIHPPPVLTTSQVTSHSDPTSPNMPPKPKRSSTPKTKIKINTPRTSPTPRTTNKTTTTFPKTITMKKAPTPKRKAIRHHACRLIPSCKQGHGGPAKIILPIGKYFVSEEALEHDLGALKRGAIYPNESEFYKRVKAWYKAEVDRLLHRQRVESEEKKEKEEKELDKIMIRPTAMTKPGATKRKLAATSDSNDMELSDDRSTSDSADSPSDSEYSDFQNKPPRKPRASRANTPIRKNPEMLQTPSPSPDKPTPTRVQPTRAAKRKAETPSLPPTPPKTPSPKRRKVTLIIKRPNQEPKAEQPENNPEETKGDYSLSKLDFKESQPSYADRGEMADGLDVAYFMMSVEKAVEGAINELVAARLGNGVLSLSSPRESNKGIRARWRRFGSISHAGGQGRIAQESKNEEDEVFEPAGDAVPGEDWRPPQPPRSAPATLELGKGGKKGVKMQKGLELRISSKEGTPAPEAVMEPSPTLGRWQLADRRASGSSGSGGYERSKAGDVAKLKVEVDSEAVAAEKESAPGSGGGVMVESPVEESNKRSVQVSGLKFDVELRTLEVGQDGEGRKDIWFHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCZ5</accession>
    <name>A0AAE0JCZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_427609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680528.1">
        <property type="nucleotide sequence ID" value="XM_062824700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCZ5"/>
    <dbReference type="GeneID" id="87861854"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="322" mass="34998" checksum="9C39DA6A55CE0128" modified="2024-05-29" version="1">MQINDSRFQNHMALTVLEGLFGMEGQQMPAVNGQQNIVDMIMSKLANVKMGTASPDAVSGTDTSILGWPTCKDTLACNFNILQNVSMSDRLIYLVTIQVKLLGGPNKSQTQFKAVEGLMQYFIDKNLPNPNIAPSYGLAGVLEGIQRGTAIALGKSNDTFGNPSSLMWASFLRKAFQVGLNYGVQTGDRLTGTTVGVNGYVEIPERAAVFNILTAWTILAQNEGVVGRIFSLIFETDQANASQSAPAIFLPLLPYGFTAEKLINWIFNVSDPKPLYCLVDAAFNDRAIAALRIDPTTFLNDLNNLITIIPAFLRCYTVGANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD69</accession>
    <name>A0AAE0JD69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_226458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680476.1">
        <property type="nucleotide sequence ID" value="XM_062822133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD69"/>
    <dbReference type="GeneID" id="87859287"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="383" mass="42818" checksum="87F0550A44A6080E" modified="2024-05-29" version="1">MTSEQVPPPLAAARTHSPRSSHDLVTVVLTTSPTPSAPSTELLSSIIASFQKHCAPLTKCRVILVLDTYDRIASDSRLKKGTVTAEGAKKFAEYKENAKKLILDEYSRSHCGAEIVCYDDELIITEGEAEFGSVAYAQQHNAVTLTITRTKDGRITFIEPHARVGFGLGVRSALRLTETPYVWIQQHDWALVADIPLAPLLEIMQQSESAPESPDSSDSETTDGQEPRTTSDVPVKYVCFPSTRMVSYAKSDHVMLYPALRALTNLYKQNFSVGSGCSSVKIPLTPLFFWHDKPHLASTAHYLSQIFPSRAAMLRGAFIEDTAGQRARTEMKDGLWRKWACWLYYPDEGTKLCVRHLKGRTWRGTDGELVQRMQYMRLNSFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDE7</accession>
    <name>A0AAE0JDE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_540100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680227.1">
        <property type="nucleotide sequence ID" value="XM_062829141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDE7"/>
    <dbReference type="GeneID" id="87866295"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="193"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="882" mass="100821" checksum="A174F04A680B8D28" modified="2024-05-29" version="1">MLPDLCCGAAKHHGRLLPHEMSYDRSTPVNDWVEMLEKSLIFGKAQTLCIPQPHSILQTAVAQDLRPLLPDTIHHAPFYQSRQSVTYVFTNEPRKYHQRDVNYDLIPLRIKLPEIRLLELFPAPNFTDDLWCRLYTALIEEPPQYAGDGLPCSKCSVQDPLWYINLQRRYGRDACQGCGLTKDNGRTFEIPSYHALSYAWGDCTKSHKIFTIKPTAGDHQHGISPASRSTDGDGSANGGHGSLIIPITASLDSCLRQLRSSCGSASLTIWIDQICIDQSNDREKSAQVELMRKIYSLAQRVIIWLGPTAEGSDDVMDAHAHVAQIFWKYHRTIPMGNQPALANLDRFVATDETWSLPDFQDTINEVVMIYAPLIQDHKLQKWLSRDWFSRIWVIQELSLSRDAVFVCGEKSLDAVDTFVSSRLFEEVLWRRVHENPTYELKLPQTLTHILGFFAKDYLRQLYYEFSAILTKTAMVLTQIARAVIEKEHDHLEVLSLAQFPKQGVTEMEDGVDEQFPLPSWVPDWYNGLRRPYRAYHGRVLRSFSASLNTSVRVVPTVLQSTLGLRGYLVDTIEEVGSYIQNRDSSAAITLDKYDKVAKLYGLLCSIKYFWHRSAEKGHGIYRHAPRQNEALWRVPIGDLWRWSEREEGQPVSIRPPSEPGAHIFEQALEYCRNWTSIGHQRIQHTIPDVKFTPILSQAEEEVVQRAEDRKGVLFKYLCHLNLMFELRPYLTKKGYMGLAPSYTQPGDVLVIFSGGSVPYVIRPVTADTDRYRFKPDAESQVKSDDQSRVGSATEAKQAVEDCHDPNFKLPESSLYTKEQIQAMYEKHKLHLSSRPQRKPVVLPTRPDENDSIYTFVGEAFCDGIMDGEFMERAGDIEDFFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDJ2</accession>
    <name>A0AAE0JDJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_526462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680302.1">
        <property type="nucleotide sequence ID" value="XM_062828857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDJ2"/>
    <dbReference type="GeneID" id="87866011"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="752"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="811"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="904"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3342509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118811" checksum="E2000E3696016526" modified="2024-05-29" version="1">MASERALHIEDYESGIRSGLITRPQPDLRKYVGKIYEIEDRGRTLSRTVNHIIATTPIRASREDAEQLLDQYIEPISETVEFFREIKTRESHGFLDALHNVRSGPAVEVKMLRSLEDLEAIWKRAVDDAERALDKSLDELMSHLVHYQVLEALLVEQEGSERLKHLIGPSHIGSTVLSSGRQNGEPDSSGHIMIISRKRKTPGAPTTSTPRTTRASAASRRAASARGAVPDVYREMVSEARRMAVTEDPPEATTPERPLKRRRPGERPTPKVETKPVEPTVIPEPMKMDHNNEEEDDDDEELEFEDVELPQPTLQTITRDSDDEDDEELELEDIAFDSQGAFSSAIAGDVQLDLNLSAQKAAMAPHRRAIERRKALSKSEKERRMEIHKVHLLCLLAHVERRNKWCNSPKVQEALRPLLTDKMRKSLIPRASLNQYGRTESLKAGLQETSTMFKTKFQITERGLRRALWAEDEDQLKNYELPDDLETVRSKDDFLEAAKSLSGSRDVGAQLFCALLRSIGVQARLVCSLQPLACVPGAPTMPKQRKMKSLDASKGPSAADRYAAAMSKYENTATTPDPTTPSFLSGRSRLGHPNATAYNVPSMTAPPPPPPLPSVPKAKTIKGESPYPVYWVEVLDVVQQKWHPVDPLVTGTQWRPRALEPPASDKENTLTYAIAFDEDGFALDVTRRYSKAYNSKTKRQRIDGPISPTVPSSGINTGERWLRRVFLRHYTAPDFPTDLDQIELKELAALEGAEPMPRNVQDFKDHPVYALERHLRRNEVLVPGAQSTGTVSAGSKAPVERIYRRKDVVVARSREKWFRLGRVVKPGEEPVKVLPPNKRKRTSKFGGERISSPVSGDDEDDDGDLFGDYSHSLAKQGGTPLYTPLQTDLYVPPPVSSASSGKIVPKNKFGNVEVYVPSMIPAGGAHIPHERAAQAAHILGIDYAPALTGFEWKGRKGTARILGVVVPEGAAEGVRAVIDGLVDMELEEREERRRVEVWRMWRVMLRGLRIRERVFGGVGDEEEDETEEERFDREMADAPSDVSEEFYMDMDDGEGGGGFLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDL9</accession>
    <name>A0AAE0JDL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_496237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680651.1">
        <property type="nucleotide sequence ID" value="XM_062827795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDL9"/>
    <dbReference type="GeneID" id="87864949"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041982928" evidence="9">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3342858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="219" mass="24829" checksum="AE56B25B28C193F5" modified="2024-05-29" version="1">MRSFLPLLSLGAVAQALHFFIDGTTPKCFYEELPKDTLVVGHYTAEEWDDQRHSWQKHDGINIFISVDELFDNDHRVVSQRGGPGGKFTFTAAEAGDHRICFTPTSTSGRSSWMSVSNPNGGIKLTLDMAIGESSAIESADKGKLQDLATRAKDLNNRLQDIRREQVFQREREAEFRDQSESTNSRIVRWVLIQLIVLGITCAWQLSHLRTFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDP1</accession>
    <name>A0AAE0JDP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_550409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681030.1">
        <property type="nucleotide sequence ID" value="XM_062829732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDP1"/>
    <dbReference type="GeneID" id="87866886"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="480" mass="53153" checksum="60E9E9F2A0F3BFC0" modified="2024-05-29" version="1">MISSTIGKAMGILQGLRVGADHLRAVPRTDTDIVRKATLCIFSDAFEVLRMIKYQNLNTSFRQEFIAKVINLVEQLSHELGNIPGFDVALELHWMRGHVGFEENEQADDFANKARPRYEGRDIFHSHGRGNRRRNHRRRANNAAIFSRHASHDGMPYSPPPWATDSFGPNITSLRMPRYPSTLPFSSTGGERPRVSEKPRPGTNEQSPTPKKQAPLNATNNGEKPAVEIEALEKDSKPERGVADMQTTVIQQFVVEEEPTAALDISQNLNKPSAGLESPANEQALACLKQEEQGELMVNLEKEEPSMKPEVQTPVDLPAAGMEFAANEQDLASQKVDEQQDQLPISEVQMPLNHEVVQDTEPLSDLEVQTPVDQPAEENDDSALGPLLDDQTMIDLQLEEEYLKWCERRLQDALASADNVDEDGIGETSTNEEVMSEEETQAAVDRQLAEEAEAALAQMMASDVQGHVPLGLRIGGAQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDW9</accession>
    <name>A0AAE0JDW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_179850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681175.1">
        <property type="nucleotide sequence ID" value="XM_062821493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDW9"/>
    <dbReference type="GeneID" id="87858647"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01303">
        <property type="entry name" value="GDEase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF49">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="73"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3344562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="454" mass="49829" checksum="C2313E5C9CD058AE" modified="2024-05-29" version="1">MGSHQVKAQAFYGAVIHSLSTPGHDLEILPSALLIVESQGVVTSFHKDVKPGEVESLVDTTATTLHRLSPSQFLIPGFIDTHNHAPQWAQRGLGQGQHILDWLSAITFPNEGRFRDPSHAQRIYSSAIDGFLRQGITTASYYGSIHPEATNILADLCLAKGQRAFVGKCNMTRNSPDYYRDASIEQSLQDTESCIAHIRKIDPEGKLLKHVLTPRFAISCDAECLAGLGQIAAKNPDLPIQTHFNEAEQEITATREFFPQFSSEADLYAHYGLLTKRSILAHCCYMTPYEFDRLKELQCGVAHCPISNMTVGGGFMAAPIREFLNRGIKVGLGTDSGGGFSSSMLDAIRQAMIASHAREVESKGRDKGLKIAEVFYLATLGGAEVCCLEGKVGNFEVGKEFDALVVDWERDGVMTMVEEEDGLGTVFEKFVMTGDDRNIVRVFVKGRVVREVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE92</accession>
    <name>A0AAE0JE92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_244568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681058.1">
        <property type="nucleotide sequence ID" value="XM_062822369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE92"/>
    <dbReference type="GeneID" id="87859523"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018830">
        <property type="entry name" value="DUF2434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10361">
        <property type="entry name" value="DUF2434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3343265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="554" mass="62386" checksum="38A67AB5B19A2078" modified="2024-05-29" version="1">MTIIGARDILAWPGGDNSSDTVLSGLHFNLTTLENWNYTLYSNGTLSNGTKCYLSFEPYAPAFIFPNGTFVNATQCWHPVYPIGARAGTGLGFAVAFGLGLVLTLVALNKHGKLHLPSEKRFHPIGRRWQWYWALFTCATALISLFTNIDVDRYYLPEIPIVLTSFFWYLMQIGAIACTWEAVRHWGSWMERQFIDPNPFRLRQEGRRYWVELLIPLFAYLFMWLNFFIVVPRSWGKIEHQRYPEQIITDAEPTATDNRFKSAPFFLFATWLITVFSLWHSIRHYCPRNRGIINRTIGLFKFTPTRFMLIIPLAFIVPLFQAMAAWNFAWSPLNVKGKPEAIYPGGYAPALLIVIIQGIYGLTSPNEDRELIRQRRERGQILDAELGIQRKPAWWRRVNEAAAGPNETMRDRIMRNVREIGGGGPTARNLYESIHTRAAESGEPRSPNAPNSPDDVEMVSIPSPQHVVGVTGPIAPGDFATARQTATRYAGMTPSAASRQAELMMDGPRGTVPPPPPYTDRPGVGETGRNHSVVSSTSPSITSPPVQVRSMLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF21</accession>
    <name>A0AAE0JF21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_427385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681493.1">
        <property type="nucleotide sequence ID" value="XM_062824684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF21"/>
    <dbReference type="GeneID" id="87861838"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="8257" checksum="3922BFBD216EFA16" modified="2024-05-29" version="1" fragment="single">FINNIIIFSDTLKDYIKHLTQIFQFFIFRNITLPQTKSYFIYPNIKFLTFYIDILGLLITAEKIKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF80</accession>
    <name>A0AAE0JF80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_200436</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681852.1">
        <property type="nucleotide sequence ID" value="XM_062821776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF80"/>
    <dbReference type="GeneID" id="87858930"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="29"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="509"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3345239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="657" mass="71565" checksum="72C958FC5C9729C6" modified="2024-05-29" version="1">MPALAITNFNIVLSVLGGWISLFGLVSYLCKESYYMSEAFISLLVGVAFSPRAANFIRPLAYADYDPIALQEITLAFSRLVLGVQLVLAGVQLPSRYLHQQWRPLSMLLGPIMFMMWIATSLLVWALIPSFGPNGMGFLKALVIGSCVTPTDPVLSNVIVKGRFADHNVPKELQRIIVAESGANDGLGYPFLFFALYLIKYMGHDYPGDGAGAGRAMALWFCETWVYTIILSIVYGAAVGWIAKELLHWAEERKFVDRESFLVFAISLALFITGTCGMIGSDDVLACFIAGNVFTWDDWFRLETLDDSLQPTIDMLLNVTIFMWYGAVCPWEMFLRNGVGVQIYRLIVLGILVLLLRRLPWVFIAHKIPWGRKVIPQIEGAKQAIFVGFFGPVGVSAIFYLYITLEFLRGMDGPDGKPREDVKDLAETVTVVVWFMAICSVVVHGLSIPVGKLGVHLPRTLSKGLKSGAASPSRSVILPDSRRSSGGPLPSFNIGDRVNSFITGMRPGWVRPAERRTHDEHGHDAERHGEAAEDSQQGIPLTRPFYRTGGTIIRNPPASGTGAVESEAQGVAAVGDVEGPSQSQSRPDTTSANSSNTTLDDGRRGRGVSATPAAREAAASKSHSRAPGRSIRFPDDNSQGVGSAPTLVGENTASIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFK5</accession>
    <name>A0AAE0JFK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GET complex, subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_524634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681686.1">
        <property type="nucleotide sequence ID" value="XM_062828822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFK5"/>
    <dbReference type="GeneID" id="87865976"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="39712" checksum="4A554C1EB8C586D9" modified="2024-05-29" version="1">MTEGVEVSPADAAEARALEQARIRKERREAKIKANAGNRLNRITGLGGGVERDPAPTAPVASSSNDDQTSPAPTSTSAPRVHADPEEVDISASEHYYQPTTTPRIPKQQQQPQPTQGLSPFDPNGLSEESLRQMMLGRDPAMGPGGAGGDPFASLLGGGPGGPGGPGGPGAEDPMMQMMLNMLGGGGGAPGAGGAGMPPFPGGGFPGMPSMGGMMPPGMGGMGQQGVPPTMAVPDRYSSLWRLLHTAVALGLGLYIALCTSFSGSKVDRDSKNILTGNRHHHAGAGDQVAVGYDTDSARRFFYAFATAEALLLTTRFFLEKGLGKSPAGGAFGGGMLGMAAGFLPQPWKGYLEIGLRYGQIFSTVKADILVCIFVLGVCSWWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFN0</accession>
    <name>A0AAE0JFN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_509145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682047.1">
        <property type="nucleotide sequence ID" value="XM_062828283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFN0"/>
    <dbReference type="GeneID" id="87865437"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="35"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="156" mass="17800" checksum="25ADBC3F45AB108B" modified="2024-05-29" version="1">MHSHYDEDQDIMPDFGEHVDNGIFEQILEMDDDDKREFSKSLVTNFFDQAEETFVKIEEILNNNKLDNGKRLETLSSLGHFLKGSSATLGFNKIRDSCQVIQQYGHKLTVDGAAEPNEQVCLEKIKAALKTARNDKDVLADMMLNETHGFFQPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFW6</accession>
    <name>A0AAE0JFW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytokinesis regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_442736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681958.1">
        <property type="nucleotide sequence ID" value="XM_062825591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFW6"/>
    <dbReference type="GeneID" id="87862745"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1234" mass="137620" checksum="2FA66284955895AB" modified="2024-05-29" version="1">MELEPKPRGVEEDAHEHLPDSGTFLTITLTTFTPLIVRSCSSQLNSAAPEQQRQQQHPPREPTYHTTHPPTTNSPTSPFYHHHPPFPPCIRTPTPWSHRANANHSAHPGCLEYHPIVIGGPRVLGDDYESSPLTRSLSSLHVAKRPHLTPFRGTHPRNYHQYPLTAHHNVDLVLQDHTTPPAMETLRLKTRPPVEDDIENWDDDDFLIEGDDFSIQSHSTTANAHPHRRDSHSSFRSDFESIHGEEEKQVHLPGDDEKSTLDALAAAERAGIPLPKNVPPSALMGGTIKRLGGRKIRKIIQEDWVDDLEFPSDAGQLQIKKRDSSQFPEAIRQVSGLFQPRPQPARRTSGSFSGRLEPVRKTSGSFGRPEAMRKTSNTFPGRALPPQKLTVKPMDVQVRKASRPSLTSTGLIDLERFRDMDDDNDFFGDGTETIKVKKRRNTLKPITFITPATPLKVTPDEDDFEHDFELPMDGTLRLSNRRETPKLPTLNTSDDSEWGEGSLGTRFGGTRRDAFSTSSVSAFSPSIASSTVAESEDEFDGIILPPGPLNWEERLHRRQQSTSPERIPEEPVIVERVQKKDREEQEDFLSGLDIGDGEVFDSKKLTLHRNIKVKDTRGDSPNRPKTSVALKFTNKPVAASRLPRPMGSMGLLVSHERTQTQSSLEPVCETGETVTRSSSRRSLTRSGHHSQASITSVMSSGASQPAPSTTTTRRNMAQKTTTTSQKAEPTTTNAQLLRMKRSVPGLRPQNQARPTTTRNYERPPSRTEATRAQNSVRPKTPVERVRNMESTVTTGRKGSVPSVTPFLPAGASSSQSYNVNATRNTRNLRRHESEGGIDYRPISRGTYSRASNKRSPSPRKHRSVDFTAAEGNWKQLNKPFRVRNFGDGHELDGFDDLPTSTQAEAKYLRQPVNTGPKAQARNRLYQNIAPNDRNNVTPSPPVTSRPPTRFNDSNVPSFARDTAASRRARESCLAQRNVSGQLAPLTAQRVAQLSTNRGNLHQSTPSAPPQATMKSSRKLRKTPQLKPHLISNLNPPKDSKIVKGMCYNPETFRWEGNDNVLRAFEAPASSPSTASVKVQHVVRERESATPRPALITNIGTTKGVQVVKGMVFDPQNMCWLKLGPQNDKAAERGRSKNGSVSEAMDDEEDVFKDIPDLEDHTITSTDGGGGRTSDVKDDWLVGEEFDVGPEFVRRQREEEERWRKKCQAWATGRSQRGEAWKWAIRDIVNGTVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGA6</accession>
    <name>A0AAE0JGA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_209550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682198.1">
        <property type="nucleotide sequence ID" value="XM_062821914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGA6"/>
    <dbReference type="GeneID" id="87859068"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="185"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="551" mass="62746" checksum="3E5742E20B31EBA4" modified="2024-05-29" version="1">MDDDYKELRRPHRLGFWLLPFNKAAAALVSCHPRNLERYPYDEDTRGIWIDFSDPEKQDYTVGCSDSVDIYLPQVWNSTGSSGISERHASFRAVTETGPILLCDESEYLSTEPFSHGSRSYTVNFRREGERSVLVAQGINSLVAFGHGRFYQFELRWENDGLDQFRMEPPVLYALGPSRVKTKSYVLGGKVGGGTFGNVYRAMDVTTGSVMAVKKFHRLSSKRLDFASREIANLIKINSDESTRCDHIIQILDYTTSSDWAEIFLPLKLGNLKTLVQKILPPSSHFEVSNIVLHQMLLALHHLEQHKIIHRDLNPENILWELDSSSGSGSGSGTYHFTLADFGLSTSTLSNDSKRAFSRAEVAGTTPFMAPEVYNRHKQKQTSKVDIWSLFATVVWVRDHRFRKGCELLGPHLVHVWLNRIAGKGQGGYKAVRRMACFDPGRRPSAGEQLEILEEEAELEELEEMEEMEARFAGMGLQWNEGMGFEEQEENEYLTETPYYQHDQPYMAGAIDGYGWDGTNGAWSREGYVLPMEAPRDQEVSPYQWWKQSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGG6</accession>
    <name>A0AAE0JGG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_148308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682484.1">
        <property type="nucleotide sequence ID" value="XM_062821035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGG6"/>
    <dbReference type="GeneID" id="87858189"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042216437" description="DUF7907 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="3">
        <location>
            <begin position="39"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="271" mass="28478" checksum="B370822C3533C125" modified="2024-05-29" version="1">MLTKILLALAALALTTATPLHLDDSSPTSQQPPTSTALGFALVANLTDPDMARNLFLDDINHWSLRGVHVGAGQSTAVLAKPNTTASGSSSNTIAERSSSSPHQIYYQNSTGGISLDDSNPFPLSIRLGGIYDSDFPSVLYLGIFFGLSTPSISISSPSGHPRLFISSAGPGTPEAEEPTAPGSPVTDSEAPELYQHGTFIVCNETDPVYTRPQYPVRFVKSNGDGTVSLPSNCARIELVAECGVLRYLDGQGMEYGQDKPGVVGCFDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGY3</accession>
    <name>A0AAE0JGY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_149370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682543.1">
        <property type="nucleotide sequence ID" value="XM_062821058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGY3"/>
    <dbReference type="GeneID" id="87858212"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="147"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="667" mass="72587" checksum="F2DBE77EEC8D4E5E" modified="2024-05-29" version="1">MTTTTGDIMAKMLDHETENTPQQQQQQPPPPAPPPPPQDLPASNYPLSSTDDVSSLSKPPANEPSRRRHSSSHSGASASSASLSSGHLEALHQDEIASIENATRLSTVQTRTSTFSSASHPPDLEVTFSPDDPENPKNWPLWYRCWTIFACSYSTWVVVLYSSSYTAIVPGLMKEYHVTNQPVATLGLTTYLFGLAFGCLALAPLSELYGRRPIYLVSLGVFALLILPCAMPSSLAEIIVVRFFGALFGAVMVSNSPATVVDIANPDYLALCMAVTSIAPLNGPVTGPLIGGFAYQYLGFRWANWIVLILSGAAVIFMATIRETYAPAILRAKAARLRKETGDDRYWSRFDQKVSTLQLLKTNLSRPFILAATEPILWFFNTWISLVYAILYLCFVAYPIVFKEHRGWSTGQVGLAFLGMGCGTVASIVLEPFWRSIINKRTSKFDAETGRPAPEAQAYVMTIGAVLTACGQLAFSWTCLPVSIHWIVPIIFGVPFGMGNTISFIYGSNYLAGAYGLYAASALAANSFLRSVAGGVLPLAGPSMYRNLTPQIAGTILAVLEVLLIPIPIIFYRYGERIRGRSKVIRIMREEQAREDKRRFKQSERARRRGAAAGEKDEESAEGNGMVETETATGEGEVSGEGVVVVASTLGTSGEKEETVKKDDEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH01</accession>
    <name>A0AAE0JH01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_153046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682767.1">
        <property type="nucleotide sequence ID" value="XM_062821104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH01"/>
    <dbReference type="GeneID" id="87858258"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="259" mass="29077" checksum="79F07B6880889B6E" modified="2024-05-29" version="1">MDASNFLAHRAPTELIYAIFQSITSEHIQGAVALSLACSSLRNHWTTHRSALLWNLCVEHVPHAQEALLAARMTRKVADAEIRGRLPPMDISPGDLLSGSASPKLSMTLSEYHQVRDLNLLARNREARLHHWPCRVWSFPNDRPQQARGETVSPEEPCSMPEWSDRVHLALYRMMILAAGLAGAYHEPTLKATDPEAGMSLIFAWMSAVVYPRSDVTCSVYSDDRSLGSRFISKHGRYRTFPEPCSRAEWHGNAFKVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHJ1</accession>
    <name>A0AAE0JHJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_490842</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682691.1">
        <property type="nucleotide sequence ID" value="XM_062827738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHJ1"/>
    <dbReference type="GeneID" id="87864892"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3347609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="503" mass="57521" checksum="44EA5EE687FC0974" modified="2024-05-29" version="1" fragment="single">MLVENAGLLLSAAVPILLLPYLLGAVISTLRLRWYTSGFPVINKLKGEWSDKPAVKRIARDMKAWIQKGYYKYNGPFQIIGSFGTRIVLPPDMAEHVKSDPRFSADEVVKKSMASTLPGFEGLRATDALTTMIRTKLSTNLGKFTQELAEETEVAFDMRWGTSTEWHEVELLASLRDIVTQVSTRIFLGPELCRDEEWLDNIQAYTNSVFHAVRVIRSWPEWSRPYVQWFLKDCRKIRQQVKRAEEMIEPIIAKRIETTERAKKGLADMPNDAMTWMHQIAMSRNEKYHGAHAQLSLSMASVHTTSDLTSNIVLQLCRHPEVIEPLLKEIREVRDQDGKMSKTSLYQMKLADSVMKETQRLKPLGVLLTHRYAHEDVTLPDGTLIPRGAQVGVNMSRMWDPKYYPNPEEWQPDRFLKLREEAGKEHPSQFVTTTMESLGFGIGTHACPGRFFAGNKVKILLAHILEHYEFERVDSGPDASPWYIEIVTNPKAKLRVRRKQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHR0</accession>
    <name>A0AAE0JHR0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_165441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683169.1">
        <property type="nucleotide sequence ID" value="XM_062821291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHR0"/>
    <dbReference type="GeneID" id="87858445"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3348087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="718" mass="80451" checksum="91D333902978BE4B" modified="2024-05-29" version="1">MVYLGKPSKGCQVCRTRRIKCDETKPTCNQCLKARKQCPGYKDDFDLVFRNVTKATERRVQRANKKGKQRLSTGSDGFSPGSGASRPPSSSSSVSVSSSSSVDGEQQFSLTSTARKTVRSPFELAVIPAIQIPTETQASCHFVSNFVLIPRQGTTRGFMDYLIPLMKTETISSAPHLQFAFNACALASLGNRVKSDGIDFVASAHREYAKALRATQAALMDRVKCTSDSVLATVLLLGMFENITAKKMGEFAWGSHIEGAIQLVKARGKKQLTTQIGLQLFIAVRTQQIIHALTSGCPPIMGVDWWLDNAVNDSYAAHCCRLNLQTSELRAEVTHIMTHGTAGTSPSSPSSPRSPSAQPSPSTYEQRTARILSFMRRSQELDRAIVDWMASLPPHWRYRTLCWQNYVANTDYAHAEVFPGRVDVYNDVWIASVWNMARVTRLILASITVRCAAWACSPVDYRTTPEYAHSARVCAEVISDVLASVPYNLGWHYRTKRRRRQGQGQGQGRGNRNRNRNRDNYDDDDDEEDGEDDEQEEEQLSGFGCGEDDEGMKGLSGYFLTWPLACVMAQDYLTEDQRTWVRGRLRYIGEELGIRYANILAQLQVRIPSMLIRRDGLMAQPYPNAQDFQHLLSSARNSPPILPGYSLNPIQEREKMQMEFMELKKKELLAKATGAAGKEGRYDETTNKSGRMGNKGDSEERREEEENVMFFARKLLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHW3</accession>
    <name>A0AAE0JHW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_461924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062826621.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87863775"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10308">
        <property type="entry name" value="GST_C_eEF1b_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000001">
        <property type="entry name" value="Putative Elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="145"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="231" mass="25430" checksum="9ADCF8D19AA69955" modified="2024-05-29" version="1">MGFTDLLTDAGLAVLNNWLLTRSYVTGYTPSQADVAVFKALKEAPSAEKYPNAARWYKHIATYDDEFATLSGDSSAPYTIYGPEVAEVTLNPAKAPEAAAEEEDEDVDLFGSDDEEEDAEAARIREERLAAYREKKAAKPKIAAKSIVTMDVKPWDDETDMVALEAAVRGIEKDGLVWGGSKLVPVGFGIKKLQINLVIEDDKISLDELQEQISEFEDYVQSTDIAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI15</accession>
    <name>A0AAE0JI15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_170498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683335.1">
        <property type="nucleotide sequence ID" value="XM_062821360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI15"/>
    <dbReference type="GeneID" id="87858514"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="807" mass="87332" checksum="AFE48700956E3737" modified="2024-05-29" version="1">MPYAPPWLNLKGSAKKKQVAKSPEDKMPTPDSKLSQSVHVSGKKKKKSKGKKKAKAHKLQEGDLADGEQASDVSGFVKGQSPTLSTKDETFVTVEEIDPQEEEMVRIKKEPMSPTLPKATVFQEAVAPEGSVADEHFSTPLQSPVPTKSELTKENAPLRSESRVPLPRYPPFEHAKRSASPSPSSQLHAENPTALMSLLNNINSRNEKNSTMKARSPQKFKLTPVPNSTLDQNFPPTSPLNSKTPGPMPRMMQFDSSPNRFSPSKSNKCTPVPLPTTKGFPAAPKLGTPFRAGAGTEDDPLTPADVDEILNRVMSKNDSGDEHGDTVMHDVEEHAAVSPAAGKRGVANGEESDVEMTTIIKDEQHDDSVADGPVKKTKKSKKDKKRRLEESNALDDDESITVSAPKKAKKTKKKKAKKISVEQEHEITMDLDGMTQVDDTMQIDDTTQVELDKQLNETEHGGASETVSAPKDVEELTAEHEVTEIVDEPASTVKKKKAKKSRKGKKAQAEVEEHQVIEIDEDVAPVIYVADTEQQSTEADQATNAATATEFLPASEAKVTKKGRKAKEVTTEPKPEEPEFEQEDTAAITASNVAATMTTNPLLAIAKQVVKFDNNLSFHSETFQGELFTIKQNLAALEQRIQANELRASIRQDILFNALKKVSIKLSASSSPAISGTSQADHHNDRSNSPDSSPASAHRDRLARSVRATTVGPNGSIHSVTPIPLPKLGKRAFSSHHRETPASGAGAGAKAAGAAGTSGAAIAEARKIQDKLLKGFTTEMNAAKDKKTVEIKGALCVKYADDLFKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI43</accession>
    <name>A0AAE0JI43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_522635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683153.1">
        <property type="nucleotide sequence ID" value="XM_062828776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI43"/>
    <dbReference type="GeneID" id="87865930"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="695" mass="77578" checksum="1BA0376F7BB40E5C" modified="2024-05-29" version="1">MESTNEPRPGDDAFNGFQMSLPENCVEYMLFIINDQPEAQRTTLSSLETIRKVALQRLDELTKDYIWQREPLKLETRIDNGLVYLHGRTDYGDNVEDEWLIVYFLRTLSISFPNLWIRIFDSDGEFLLIEAAKVLPKWLSPENDTNRVWINRGQLRIIPLLPSSSSSSSSSPPSSKAHHQISLHEALSIIRTNPNILIHSPLIEAEAFYRLEKYPGQIASSLHHTLVTIPRKLAYILHERPKAVAPAIEAFYLRDPASLKPLLSPTPDSLLFPPTDLVTISVRLTKVLYAQLKSQHFDPPPVWREHFLQAAQLNEGGGLSVSEKDEGKQALQKLQTLARLEMGMKLTTGFEILARGAEKSDSRVAREVALLLEDLAEDGEEAALPTDEEIRKWKDVDREDDDTWMDIDFADFERELAGGGGQGQTQQQQQQQKAGEDNRGAGGDAIPTFGDSTTQADLRKIVSRFEAFLNDETAGLDGAEIDEMDQDDDDDDEEDSDIDMDSEDEDKEVSFDEEQFSRMMREMMGIPTTPTSTTTKSETTASQNPDTRGKGKGKDEDVDMGKDEQEELEALMAQMEKELNSYGALQLDPQKAKTKTSTRALKGEVEEGSSKGETREIVKTTAADGESDDDDDMDDEEEEEEGGGDDVDLDYNLAKNLLESFKSQAGMAGPAGNLLGLMGMTLPRDEEDLDGEGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIF0</accession>
    <name>A0AAE0JIF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_175646</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683517.1">
        <property type="nucleotide sequence ID" value="XM_062821437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIF0"/>
    <dbReference type="GeneID" id="87858591"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3348435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="19136" checksum="56ADC2DD06ABDE55" modified="2024-05-29" version="1">MRNSRCRRDALDPSPPWMCQCFVSRGYYHLLPSLPSLLLGRLAFFMGSRKPRGKRANEPPEMYIHQQQQQAHLELRPSHQSISGLAYSKFPNKKWYLLVDDDTYLVQPSLKPLLAHLGSVPYYIGNAVGDFRIRFAHGGSGIILSQGAKAGIREREKDLTRSTQSSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIM3</accession>
    <name>A0AAE0JIM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_588085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683336.1">
        <property type="nucleotide sequence ID" value="XM_062830997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIM3"/>
    <dbReference type="GeneID" id="87868151"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042015844" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3348254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="471" mass="51434" checksum="3E8C3038DC8C529B" modified="2024-05-29" version="1">MLFTNKITGVAPLLLAAASSVYGTLEVDLNNTASVKSAAQTVAKNLISYYNGNTPGKTIGILPGPPPDGSYYWWEAGAMWGTFVDYWHYTGDNTYNALAAQALVFQADAPQNSFMSPNWTASLGNDDQGFWGMAAMLAAEVNFPLVPGEADWLEMAQAVFNTQAAPDRHDDECGGGLRWQIYPSNAGYDYKNTIANACFFNVGARLARYTNNRTYSDWAEKTFNWIRDVGYIDKNWNIYDGGHVPNNCTDINKVQWSANAAIIIHGVAIMYNMTEDAEQWGKPLTGLVNRTLEFFFPQGVMVERACELTDRLLCNIDQHSFKGYLLRSLATAALMAPDLVREPIVKALKTNIEGVIDSCLPDGTCGYRWNLGKYDGDVNNGPAGQEMSALAAFSTYLVTYQHDVIKPLVTNSTGGQSRGNPNAGETPATIMSMSELTGRDKAGAGVLTAFVVCTILGTYFFLATGIGERKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIQ1</accession>
    <name>A0AAE0JIQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_161439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683062.1">
        <property type="nucleotide sequence ID" value="XM_062821244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIQ1"/>
    <dbReference type="GeneID" id="87858398"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3347980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="305" mass="32833" checksum="0D573F0E414ED86C" modified="2024-05-29" version="1">MYDEKPSVENISTEQAHAQAQAQAQLQAQAQAAVAAAHQEAMLSGWHNPMARIHTGTEPRLPAFGGEFQPGLYRPVKERKFANPAPLGLCAFALTTFILSCVNLNARGLNTPNVVVGVALAYGGLIQLLAGMWEMAVGNTFGATALSSFGGFWISYAILLTPAWNILGEDGPYASDAAKAVDPKMASSAVGIFLTGWFIFTTILLLCTLRSTIMFFMLFFTLDIAFLMLACGEYANDNGALTASHKLTQAGGVFGMLAAFFAWYNAFAGIADSSNSFFLLPVFHFPWSEKGRESRMAAKSDRDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIV5</accession>
    <name>A0AAE0JIV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lecithin:cholesterol acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_423840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683137.1">
        <property type="nucleotide sequence ID" value="XM_062824483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIV5"/>
    <dbReference type="GeneID" id="87861637"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="630" mass="70561" checksum="1580BA61AFF38FAC" modified="2024-05-29" version="1">MATTVRRRLVGKDIECETASETASETATSREPSPDNQHDTVKVTHKRPKTRKRKTTAIFLLGSLFGIIAAGFFAKSNDLIDLPLPELKELSMDSLFEVLPAGFVKEMRDLVNGERDLIESDDAFSVGLKMRAEGLSADHPIVMIPGVISTGLESWGTSEPSLPYFRKRLWGSWTMMRALVMDKEAWKRHIMLDKTTGLDPPGIKLRAAQGFDATDFFITGYWIWNKILENLASLGYDPTNSYTAAYDWRLAYANLEVRDHYFSRLKSYIEQAVFLHEKKVILTSHSMGSQVLFYFFHWVASEKGGKGGQDWVERHVDSWINISGCMLGAVKDVTAILSGEMRDTAQMNAFAVYGLEKFLSKEERAEIFRAMPGISSMLPMGGNAVWGELDWAPDDQPGQGHSYGSLLNFRAGQNGSTTPDRNFTIEDAMDYILDTTDDWYRDQVKGSYSHGVAKTSAEVEANENDPRKWTNPLETRLPLAPSLKIYCFYGVGKPTERAYFYRAPDPGTTTHLNMTIDTTLTQGHVDHGVILGEGDGTVNLMSLGYMCNKGWKMKRYNPAGSKITVVEMPHEPERFNPRGGPNTADHVDILGRQNLNEYILRVAAGRGDTIKDFIASNILEYAAKAKVYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ43</accession>
    <name>A0AAE0JJ43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_492706</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683653.1">
        <property type="nucleotide sequence ID" value="XM_062827755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ43"/>
    <dbReference type="GeneID" id="87864909"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="161"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3348571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="252" mass="24910" checksum="97903F2FAB975243" modified="2024-05-29" version="1" fragment="single">MCAGVWGDCCNAAGRCGTGPSFCGYGMCQLGNCSPSPSSSTTTTTSKSSTSTSTTTTKPTSTSSPKTTTSNPATKTSSATTPKSSTAATTTSMKPPSTTIPGLAALPSCGQTCFNNMLAQYSTLGCAALDGYCLCNNVNFKNGIRDCSNGACGTAVGSTVIAFGDAYCSTAFATHIATATGVAALPSCGQTCFNNMVAQYSALGCASPAPSCLCKNANFGYGLRDCSNGACGTAVASSVIAYGSSYCASATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJD7</accession>
    <name>A0AAE0JJD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrase and lipid transport-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_518113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683954.1">
        <property type="nucleotide sequence ID" value="XM_062828690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJD7"/>
    <dbReference type="GeneID" id="87865844"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="100"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3350659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="323" mass="34510" checksum="423F8A9B7F71ABEB" modified="2024-05-29" version="1">MPPRPSLLVPASATRLLLIPRTSVRSLSSLTTNNAFNEPPPSHSRRKTSLSPTPLTTTRPYSSWLLSAVSSAASALNNASGSPGGGNSSPETVLRARRILPYPPAHLYNLIADVSSYSQFLPHCSRSVVTAWAEQPTTQPTQQPTAIAEGEGGQQGAAAGEEGKEQQARTKTKWPARGDLTVGWGPFTESYSSRVYCVPDDGQGIGIVEAVSGDASTNIPSAVLRQFGYKPPAPNGDTEKMEGLFESLVTRWTVRNVPAPPGGGIGLKKSQEGVGDKWTEVALSVRFKFANPALGFAVGQLAGQKVDEMVAAFEERARRTWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJT8</accession>
    <name>A0AAE0JJT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_545682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683866.1">
        <property type="nucleotide sequence ID" value="XM_062829401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJT8"/>
    <dbReference type="GeneID" id="87866555"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3350571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="84" mass="8768" checksum="2857A4607832919B" modified="2024-05-29" version="1">MATQWMCCQCKSTGRTGDHCDRVLQQASASSVSAPFTSPSSSSSTMNVTSAFKAAAAEETEGQKTDQQETKDCGANYAADGCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKK8</accession>
    <name>A0AAE0JKK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_105011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684256.1">
        <property type="nucleotide sequence ID" value="XM_062820475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKK8"/>
    <dbReference type="GeneID" id="87857629"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="191" mass="20834" checksum="D011FB27AD44267F" modified="2024-05-29" version="1">MEDNRQARRLGEWKTRVVNLFNLGSTWRVAGCLKDIKGGRLPPLTPLTTITLHTIHHTFGPAVSQSITTKNLTRQQTTKLLLRSSLSLKLSPVQSTISQRIFSCPLHHLATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTINKMNGSNPKNNSEPNRSAFPFTSNSSFSHFREAIGATSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKW3</accession>
    <name>A0AAE0JKW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_125177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684849.1">
        <property type="nucleotide sequence ID" value="XM_062820730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKW3"/>
    <dbReference type="GeneID" id="87857884"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="450" mass="50919" checksum="49899CDC5CFB0F1B" modified="2024-05-29" version="1">MSAGPSKNNDTVGSLLASIATYLSDSLRALRFADKRHWGPDEFEQIRALEDALDDAKTDFQELGVLVNGQFYYEGDRTPESLNELRALLIKYEFHARNFKDWIRQGGPINPTWLSETKELQLELHRTQCHAARRIFAAEQEGTWMRCLGAYQVYRQQRRNEEAERIRKQKEEEKREKETREGAGGKQQHRDLERIPPWQRHEYQQHQQQQQGKGPTDEGLRPALRRGRRLSLEDLVPCCNAVGRFERFGEHDVAFVCDFCDGFIVWPDLQRMPSTRTALDQSNGGGSTSTATSTLPTSTTTATNSPRKLILPTIVTASYPAATNPQLSGTTTTAQTETTTETTYPHWQAQGLSAKTGEAKTVVFAPIAIANHMAPVPGDWLARIWCPYCDEYTYVDQGEDSEDEVKWAQDERGFEDLASFQEHLEWYHTALPVPSIPALLPKAAGSCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLJ5</accession>
    <name>A0AAE0JLJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_419190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685167.1">
        <property type="nucleotide sequence ID" value="XM_062824191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLJ5"/>
    <dbReference type="GeneID" id="87861345"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041969367" evidence="2">
        <location>
            <begin position="28"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="989" mass="108716" checksum="0E35437CF2A63E6B" modified="2024-05-29" version="1">MSVKSAISSGALSLALLLFGHGHLTKAAKDPDTTYIYFDNIPYLANGSNVIPMSWSALEAGFADPIREDIANFTGLDWTKPYPGSPLPGFTTHLRIADHLPFPAAVTTENATIDVAALNNGIPPSMRKADGLPKSMHPSWYICQHYYVSDLPDAASDVAHDCSFLPSQCQKDLKADMVANWGAYADESGGIMCGGWSLDTITPSCQEALGFVTADVLGFDASYLEDEVGARDATVDEVGRYSWMVGDGFQEPSTETTYYTASNRTYLVATVFGYSSGYKSSVQPRVELSCLRPKWIAPPAEPAEPTETTTSSSFAPSFTSTSSGSASSKTTSAASSSMSSGSSTAMSSTTAPASSLSLTLSKTTTTSTAPALPSSTTHCTGGTTAEGISGNLLGLCSYSCDFDHCLDSACVCTRSAAVAVPPPAQLAGKHGCPADNQSPTNSDYAYYVDLCEFICSREVVKLCKKLPDSNFARARNARLIMSNQIPKMATDDAKPYCFWHPDVPSENTLRQLAKRYPEMAYLVGRACAVAGYEGLYHELSLLPEVSIAEEARESDKPGSKAIFEYIMKQPVCYAVLDDYTRSVNHQNPRCPAFMNGDTAVRSTLDVTVNPEDHRYRTINYNPYYDSCPFDIAEDDHIGLVTTHIYAGQDTLPPQHVELLYSPLPLHLPTMMKDPLIIMAAYEGNLDRYLRLRRPRMVMGEHGAVLRGIYHNTTFAKWWSLQPRDGESSGDIRAATLARFIMVNDLSHITETDPDPEADFDEIPGMIWWPLVPAKETLAALAKRRPDMHLQVAMACIAGNYKELWDKLAPKPCKQLWDMATLKCDSSVRNHFVDYLERRTSELGLVASERFAGGRGAICDYPAHDWCWNAARVIKEPYDDLAYNPLCYLPRHLAIKEPNDQLDQENIYGAVEQMYLGDWELYIASTDEMRAKIPEGEDCLKLYDDVDYKQGFPRWKPSTRDTETNSLSSKEADDDDVEASSQDNDGNTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMF4</accession>
    <name>A0AAE0JMF4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_7279</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685664.1">
        <property type="nucleotide sequence ID" value="XM_062831335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMF4"/>
    <dbReference type="GeneID" id="87868489"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="276"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3354286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="399" mass="41472" checksum="CBE2D80F6D6A94A5" modified="2024-05-29" version="1">MSSGLPSVYIVSVARTPVGSFLGQLSSLSAVQLGAHAIKSAVERVPEIKAEDVEEVFFGNVLSAGVGQAPARQCALKAGLSNKVVATTVNKVCASGMKAIILGAQTIMTGNADIVVAGGTESMSNVPHYMQNLRTGVKYGDGGLVDGIQSDGLRDAYDKELMGVQAELCAKDHELSREAQDEYAINSYQKAQAATEAGLFKEIAPIEVPGGRGKPAIKIDRDEEVKNLNVEKLKSARTVFQAKNGTVTAPNASPINDGAAAVVLVSEAKLKELGIKPIAKILGWGDAAHEPERFTTAPAIAIPKAIKHAGIKEEDVDFYEINEAFSVVALANMKILGLEPEKVNVYGGSVAIGHPLGCSGARVVTTLTTVLAEKKAKIGCAGICNGGGGASAIVIENLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMF7</accession>
    <name>A0AAE0JMF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_420103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684967.1">
        <property type="nucleotide sequence ID" value="XM_062824255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMF7"/>
    <dbReference type="GeneID" id="87861409"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="197" mass="21530" checksum="3244E40AA9DA5A91" modified="2024-05-29" version="1">MMRSFTRHRSPRQRVSWSSTIDDMSSLRPCSSTSSRGRDTGFPEPFNGDRNTTLPHPEANIGPNATLGEDDISTERALMRARNSFLKEPTSSPNNAEGFMDGIKNMERMARAARGDVSQRLSDNGAAWGTTTATTPTKDSDSVMSASSGGSGPRRLETPFVNRAQPLFSPDSPESKKSTKSRGKRAWFARNVLGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMH1</accession>
    <name>A0AAE0JMH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_143248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685328.1">
        <property type="nucleotide sequence ID" value="XM_062820966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMH1"/>
    <dbReference type="GeneID" id="87858120"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39059" checksum="0DBA19F221D26742" modified="2024-05-29" version="1">MAVGTLSLFYPVILPLSTAGLLYGVHRLMYVDWAVWATDFFTGPGSVSRILLVVYMGLSWKNFPFMWHIRVFHAFLLHLLRRPPTPLGPNSLFHPSITSSYTSPLETDYNLHKSNSTYFADLDVSRSHLVTHLLGPAMSVVGDNAKNKLVLDPQGNLVKGGFGIGLGAVFCSFRREIPPMKGYEMWSRILSWDRKWLYIVTHYIVKGKVKPTSWDGRKFGPTRPKIVRTEDGKEVEEKDFSKYVYATAISKYVFKLGRFTIHPSIVIEANGLLPERPADGWRGGETGTGTPEHLGEIDENSEWDWKRVEYERRKGMEYAQHFAALDGVNSLFDGGEDGAIGKFHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMX2</accession>
    <name>A0AAE0JMX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_448837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685919.1">
        <property type="nucleotide sequence ID" value="XM_062825921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMX2"/>
    <dbReference type="GeneID" id="87863075"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="38966" checksum="0DD64ABB7EFD9EAC" modified="2024-05-29" version="1">MTSRNIPPLLEPYLAIQPSQSQSQILLTGILGANTNWLLLRYLYTLLKSKSSQTQRPQPQPQGQRRLGLRIPVAAEPELELRATPTTPAQNGDNEEGDESVGVLLVSFLRDFAFWKESAGRLGLDLEGLGRRGKLGFVDGLCCGGGGSGSGSGSDGEGAGGGGLPVRRPPVPSVGGAVGGGAVPGRGPPPAARPAPATAGGSSSSQGPAGGGEKWKRSLPSLAVADVSKTLHSALDELCQKNKKVVLVIDQLDFLLAATSDGIGSVSSALKDLLLDLREKSHATILTLSADDPLIASQATTLEKDHASFVLSLAHEAEMIVSLRLLDTGIAKDVSGVVRITRGGDCCGERQIEEKEYLYHVGGDGGVRVFERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMX8</accession>
    <name>A0AAE0JMX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_447782</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685648.1">
        <property type="nucleotide sequence ID" value="XM_062825878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMX8"/>
    <dbReference type="GeneID" id="87863032"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3354270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="361" mass="40597" checksum="DA6965B0E20D0D45" modified="2024-05-29" version="1">MARPLDPLGFEDEMCPVCKSRKYLNPDIVFVFNPECYHSMCLNCANRLFNDGPNQCPHAGCNKTLRRKGFRSAFFGDLAVEREVDIRRRVAAVFNQVEEDFETLQDYNNYLQMVEDLTFELVNGTDERRRQAEAQLQAWEAEHRQDIERNKKAGREADEMSRKRLAAERDAARQRRIEAIKEAEEEKRERVRSREMELDNLAKGITTTTEPATKVQLKRRGQVNRVAEAAPNPAASAMATGASEVERLSIRGLKEKPKAPAPQGPYDPFGGMDFAPSRYKLHGGLTHPLIEKYRLDRQHVAGGYSFDDFAARALYEAFAGLGVFVEDEKEAGSASGIGLSQETTMAAGIAAVDDADRMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN57</accession>
    <name>A0AAE0JN57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_543964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686034.1">
        <property type="nucleotide sequence ID" value="XM_062829259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN57"/>
    <dbReference type="GeneID" id="87866413"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55108" checksum="4A15CB01EE10D9F7" modified="2024-05-29" version="1">MAAAHLSTQRHPRLEPSGMDDGTYDDDDQVYDKQWASKYILGPLYEPEPSEESATRIQGLPVTSPPCASPTRPTFGTHRRRSSLAPTAEHSEELPLPPVTELERKKSLHTASPPTTRWNQGTLLTRSYSVASSRPTVNESNKLLIEKGWGVRRAVSLAEHHPKDHSHRFVETLTQKLETLAQREDQDTMAREGEYQTGRPRRASSLRERYPGDMSHRPLAMLERDHRAANRAPNLHNPRHQQPIDIIDTLDLTGPGRGVTYHHDGPYDATMASRNRNKKYSPVEAVKDTNMEDLRATPREYVQDSLVKHVPLQGTAVVPPGMQDLAGRTMDYQEGIDLMREGATSGNAYKRWEGYRYHPDDLKGKGEPSYTIEKQLKDHKATSRRARGYSHGDYASKEGVTMIEMQPRSTHHLDVPGSSSGLMGDQKEGNTRVRQRSVSNAAATTGYGGGYDYEGGGGGESSSGLRRSNTTGKNIAQSLKRRLGSFRRKREEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JND1</accession>
    <name>A0AAE0JND1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_414887</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685726.1">
        <property type="nucleotide sequence ID" value="XM_062823952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JND1"/>
    <dbReference type="GeneID" id="87861106"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="190"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="420"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3354348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="551" mass="59459" checksum="07A979D2483C5929" modified="2024-05-29" version="1">MFRNALRQSTRAVGAFSATGRVAARNAAPVVSAVQARTYADAKATPTEVSSILEQRIRGVHEESNLAETGRVLSVGDGIARVHGMANVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVKEGETVKRTGEIVDVPVGPELLGRVIDALGNPIDGKGPINCKEKRRAQLKAPGILPRQSVNQPVQTGLKSVDAMVPIGRGQRELIIGDRQTGKTAVALDAILNQKRWNSGSDEDKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYLAPFTGACVGEYFRDNGKHSLVIFDDLTKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNKTHGGGSMTALPVIETQGGDVSAYIPTNVISITDGQIFLESELFYKGIRPAINVGLSVSRVGSAAQLKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDAATKQTLNRGERLTELLKQKQYSPMAVNEMVPLIFAGVNGFLDSVPVAKILQWEADFLAHLKTNESEILATIDKEGAISKDLEAKLRGVIQTFTKSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNU8</accession>
    <name>A0AAE0JNU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_563407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686354.1">
        <property type="nucleotide sequence ID" value="XM_062830230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNU8"/>
    <dbReference type="GeneID" id="87867384"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="350"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="717"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="664"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="728"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3354976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="992" mass="110714" checksum="691E356EDC6A142D" modified="2024-05-29" version="1">MKRSSSLTSSHLGTTIPVCHPTTTRPDDCSDSWSLALSSPEQGAPRPSRSHWQRSRLGLALKALTHNEKPVSNNETKSLTFDLSRPRATTLSRRIGKMSGALFRAVAEPTIIHRKHSKGRIPIDHAFQSADDNKTTLLQFPQSPPASPTAGDMDTGSSKNSPTNSNSNPSMSPEDSTAQSSLDSRFYASPPGNSHFKSPCTRPFEKKHLQRHQHPVLNCAHANRRGVNTPSSPDSNLTTIQETALDQASPSVLTVERAAAAKIYLETYFDELLNPGPSPRSIRLQLLETHLINCGALDGKVSPSEVKAVRADFFRRESEHLRKTRVLKARSTLALVAQRGAPEASVENDWDVLKILGKGSFGVVRLVREKSQYRDEDPNGRSDGWSEASSKQVYAMKVIRKSDMLRTSQEGHLRAERDFLVASEGSKWIVPLIASFQDAANLYLVMEYMPGGDFLGLLIRENILHESVARFYIAEMILCVEAAHALKIIHRDIKPDNFLISASGHLKISDFGLAFDGHWSHDASYFNCHRYSLLNKLGIHIEGDDQDKAEGRSLQATMKWASGIMTGIDKHEKKNKDDGEPLLSWRNRCGNRTSAMSVVGTSQYMAPEVIEGKKYKETFHFPRQPAVSTRCQQLITSLIDDRENRLCSKRYRFKDLINVSMTAQSAHPGTTGGPGIGTSSYGHHRKQQPESAVPRDFAGRYVFPYDAEDIKAHKWFRGVPWERLHEIDPPYVPHLRGPDDTHYFDDEDPISDWSDSSEESEPEDPSPTSFGSPVTSDPYGSSSPISPTTPSMLGSLKDLSIGSRHPNPKDKTTSVAKQPLQGLRRDVQKWALTAIATPYDRNRLHNLDSQIDEKFVDLASEEREMLKQFVRVYGKKDRKRPRDKLLRDKNTKAVVMDVRKRTAFLGYTWRRMNHDSNGAVRKGLERIWPNVGSFVSDGNPRGEDGTFDADGVAFGGSGGYAESVYANHAGYEWEEDRAAAVKALRKGRLSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPC2</accession>
    <name>A0AAE0JPC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_504993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686393.1">
        <property type="nucleotide sequence ID" value="XM_062827959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPC2"/>
    <dbReference type="GeneID" id="87865113"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3355015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="427" mass="45693" checksum="191DFC6A147EEB02" modified="2024-05-29" version="1">MAQASVTTGSTSSLTTPSTLTPVLTSTPVPVSQSGSSSSFLTTCSSTIVNGTSTVYDPSCQPTKSPTPAKGRGGVSSGAAAGIAVGCLIIGLLLGLAAAFCFFSRRKQRHGGHGNVTEVAMTPSKDVSYAQVGSGLKNQDDSGMPELKHFLLDSLSDQELAAELRDRHHLLQQHVENHYHFHPLDATRMNRQSLLAALSQLGLGQAGSEGPSAETIVSLALDPNTRQIALQHVLSKVIFTSIDPSARSPLSMLPTSVAAFLQSIPPDEQHELRRQVDSQASTLALHWWRVLSAFLLHPQRSQRTALAPSDAALAPQAAALAQALNRFLRYFVEDSDTARFQQESHLREVIVECAKFGYVLFSQPSDWCFLHVVGHEQVAGTVSSYRGKIVCAADLVKHTDKDGRRLGGSHQTSGTLVVPSVAGWRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_400196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686635.1">
        <property type="nucleotide sequence ID" value="XM_062823782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPE1"/>
    <dbReference type="GeneID" id="87860936"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="89" mass="10060" checksum="4C97A1E8E2B70B47" modified="2024-05-29" version="1" fragment="single">LVFLRISSKGYFTFWIIAALTHLFLSASRRSIGQEKRHGHGVLIGAGRRCLRHSGYGLHTAGIFDMACIGAWCVWTHECCFSTWTRFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPI1</accession>
    <name>A0AAE0JPI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_544576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686695.1">
        <property type="nucleotide sequence ID" value="XM_062829304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPI1"/>
    <dbReference type="GeneID" id="87866458"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="373" mass="39987" checksum="693FCC4EC621408B" modified="2024-05-29" version="1">MAPGGPSQSGVISGRVTKSVPSTPGKPKPSQSSNTGNTGTGRSGKTPKWKYGFCPKCRFGHLVRKQINPDHPNQDIAGKYRLSCSDRERTGCKHYEIRNTDPMLTAPPTPSNKPICPQCTMGRLVKKCLNPFNFKEQWMECDRKNAPERPCDYRQDVHGKALENTGVVPGTQPMGRPSDHRTDGRKLDKGKAPERPGPANTANPGTRGPEPEAGPSRAAERVIDLTEDGEFTPERTPSPVPAALTVSAATAVESNDSASGPGKGTKSRLVETAADILSSQTVIDLVSDMSSQASDMTGPGEGSSKQAETLAEPHKQPAGKKADAYLDEFDSSDDEELAHLTDYIYTSARKPTPQLGVKTEAPSSPIAKIERDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPK5</accession>
    <name>A0AAE0JPK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_47531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686802.1">
        <property type="nucleotide sequence ID" value="XM_062827300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPK5"/>
    <dbReference type="GeneID" id="87864454"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="66"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="561" mass="61194" checksum="2166192B0F1D6151" modified="2024-05-29" version="1">MAKTTLFTNGRIFLSPLSPGQNAGLHTPPSFASALLIRNDTILHVGSPQDEPITTALSSTENDKVETIDLAGHSLLPGFIDGHMHLMIMGQSLTKLDLGPCKSLSDIQSTIRSYAAANPDVPRILCRGWMHSMTPDGVTAKDLDGLDVEGKYRPILVDTKDLHSAWCNTAGIKDLGADEWKDVPGGTIERDATTGKVTGVFNEAANITYVWPYLARVATVEERVAAIQAAVEAYHSVGYTGAIDMAMDEGAWDALQELRRRSSDGKEGIPLRIAAYWLVKPGKNDEENVRQVERAIELAKEFNSETTPDCRIVGVKVICDGIIDACTAGLSEPYEHNGHREVPLWTAEQLEPVVKRADEAGLQVALHAIGDETIKTVLDVLIAHASPERRPRVEHLELSSERDAERLGKAGITASIQPVHADPAILRAWPKLLGAHRCGRAFAYREFADHGAPLALGSDAPTAPHAPLPNVYVGTTRRSYREPDYQTTVNPHFALGVAEAVAAASQGVAYSCRDENRIGRLEKGMKADFTIVDMEWEKEKLKEAKVLETWFAGKKVWSAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPL2</accession>
    <name>A0AAE0JPL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_413950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686739.1">
        <property type="nucleotide sequence ID" value="XM_062823878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPL2"/>
    <dbReference type="GeneID" id="87861032"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="19310" checksum="434352C2BB953B7E" modified="2024-05-29" version="1">MTTELPDGTIIPVHDDGVVIEIKPTPPKEIHEASATKEENQQKPIPALEPAPESTPEKTKNKKTSSARAQKYREQQQLKKQQEKQQQGLLVQQGQQQQEDYSTTPNHAEQEGTSESTSIEIPEGMLEHPDPDKRTEKAVSPAERRRLIKEEIKRLAQPGERGYYQRRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPP7</accession>
    <name>A0AAE0JPP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_505063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686476.1">
        <property type="nucleotide sequence ID" value="XM_062827963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPP7"/>
    <dbReference type="GeneID" id="87865117"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3355098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="163" mass="17318" checksum="909D161BF38CD465" modified="2024-05-29" version="1">MSSTASKAGSNVSCTIGAAAAADTTTTTTTTMMHHPSAPHLSITVAHSSKALVGESENVRKLKWDIPQVLRYSALGAGIFYGFTHQRSISAAEKAAAAQREYEHKQELINKAKEAYAKSKQPVSATSTPSGRASLCLKETVNQDPMSPNFDIEAYFSALLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ25</accession>
    <name>A0AAE0JQ25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal C2 in EEIG1 and EHBP1 proteins-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_46506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686771.1">
        <property type="nucleotide sequence ID" value="XM_062826788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ25"/>
    <dbReference type="GeneID" id="87863942"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="757" mass="80738" checksum="5BC964E0A4A6CF37" modified="2024-05-29" version="1">MVHIPLVGKGKKPKFELHLKIYDLNNVPLVSGGSLIKWHLPHSIHSRDRGTTQKCPIANHRVEYNYSKVIPIRIAVDRSNNLTECPIEFEVLQLFNTNGTVNGNGPAPVREEKTTLGVVRLNLAEYVEESESILRDGLGAGISPFLGSPGGPAAVDFRFGHSRKPSSLNAVTPAPNSPQYLRPDAEEKEQERPMTAMTTKTFASTATVTPAEDVQDGVVRRYLMQDSKINSTLKMSILMIQVEGERNFIAPPLKTAPVFGGIAGLMAGDVLDPNADAHNAARNHHQAAADLALGQLPSLSHKSRDVFELQDCYRRVLAASWESQPGELTADQCIEDIFSGGDGFRTDMSSAANTPSPISRGRGGYSNNANSFGGDRDGGLRAGGHRKKHSFGGGGGHGHHFRSASGQYYRDQRDKLAAAISIGLGGVPVPVPTTPGGPNNSNTYRTPSAGSSRSRHLRRRDEPTSGSASGDEDSGSNRDNTLRPQTAAAPTTSSTTQTQGSMARIRQHIRHHSSGTSNDKSSFRTVMAEQQDQQAQAPAEGGNAADKDKDNWYNINNYGFTRGAGAADEANNLKNLLNSLNNSNGYNNRPATSASTMNVDTINTSLNNGLSPAFRDLGKMLSSAAPVVPSTATAPAAHGHGHGHGHGYLNSPYQFPYHQFQDAAASMGVVITDVGENNSYERMDFGGGRRDRSDSLASLDTLTLGSEAGSGSGRSGSGRGGGGRYGGGYGGGYKKAREVDEFEVREDLVAWTIPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR62</accession>
    <name>A0AAE0JR62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RAD17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_63585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687308.1">
        <property type="nucleotide sequence ID" value="XM_062831187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR62"/>
    <dbReference type="GeneID" id="87868341"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002611">
        <property type="entry name" value="Cell cycle checkpoint protein Rad17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="548"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="774"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="860"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="916"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="775"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="945" mass="102149" checksum="09E574C0B0F77D73" modified="2024-05-29" version="1">MAPAAKRRKRTIVDDSDAEEDEKKQTSQNNQNTLKRFLIASPVANKSAKPDDDDLLEVIPESSSPVRPVTRTTRASARSQPPATSSSTLQNRLPKAAPRSPSASPIKSRTRAQKKLKTEENGRNGDLKVLFSKQAERSQPSAASGVSSKDLSDFLEDIISESDDDIALSKTAASSFVGLQAHRRFKDNSQGTSQGSSVFSTQASTLSSTTGQRFLKPSRPARLAVAPAAPTEDDSRPWSERFAPTNLEELAVHKRKVGDVRKWLEDVIAGRMRQRLLVLKGAAGTGKTTTLKLLAEDMQCEVLEWRNPASSYGAPQGWQSASSQFEEFLGRGGKFGQLDLEGDSPPPAPAPTTNTSKQGRRLILIEEFPNTFKRSSTALTNFRNTILEFLAANTPALTTFAQAPPADSIVPIVMVISETLLTTTSASADSFTAHRLLGPEIFRHPGTGAIEFNPIAPSLLAKALELVVKKEARRSGRRRTPGPLVLKRLGEIGDIRNAIASLEFLCVKGDDDADWGSKIAFTKTKKGSKDAALTKGEQESLELISQREATLGIFHAVGKVVYNKRAEQPFPPGSEEAKAETLPNYMSHLSRPKKSEVAVDTLIDELGTDTQTFIAALHENYALSCESSPLDPNSSLDYMNGCLDYLSEADLLCPSWDIFFGGKGAFAGGNYGGKDAGSHILRQDEMAFQVAVRGLLFSLPSPVKRQTHPTSGRGGGDAFKMFYPAYLKLWRAKEELEGCVDMWATKMLKGEDGTTLSQSGTATMSLTSGALAFQRPSSTANPNNNSVTNWATTQRPQPARQEQTTASSSSAPPLLSLGSSARQEMVLERLPYMAHIARRRRCSFGSMRIRDLDKIVSFQGIGPPATEELDEDEAVGAEEAGVTESWATDKPVEEATSPGRNKRGLGAILNRAAASRVHGSGQGQEAAELGGIQSLVLSDDDIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR66</accession>
    <name>A0AAE0JR66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_516429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686872.1">
        <property type="nucleotide sequence ID" value="XM_062828667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR66"/>
    <dbReference type="GeneID" id="87865821"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF2">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="2">
        <location>
            <begin position="328"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="432" mass="47602" checksum="DF66ED5CD90C3B0D" modified="2024-05-29" version="1">MPRQFRHNLSSSSSKPYPPAELEALLKESELPGPPTPLPTKSSHEESVLDKNLRLALSLHSTSPSSSSAEEENHTPADDAPYLKIGAGACGAIFAQAGGSAIVKLAKDPNNPELWNDFRQHVKITKSFEALFSDDPPIQIPKPLGYVPPTKTSFFSATPALVQAAEPIISSLPTRALVAERILPLPRSTRHLLIEKYCAPRGKQKALADPANSDCLVRVYLGSTNGKSGGMFFSLRNLKLHLNQLTELDLDIEELASRMGIALAAMHWGARTDARDVEFVLGASSTEQVPQELQDDLDNIEADAAEPQYVGPATYHGLDDFFCRQTEMWVLDFNQVRDITLDDAGVALAVEAVKLNDPYFPKPLKESEAEEKAWKAFVFSYRKNSQTILEQALKENKGLGDMYEILALPRKFVLGIVELERERMARREGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRA5</accession>
    <name>A0AAE0JRA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_51030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686917.1">
        <property type="nucleotide sequence ID" value="XM_062828385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRA5"/>
    <dbReference type="GeneID" id="87865539"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="45"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="400"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="494"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3355539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="655" mass="72267" checksum="C3BB88D23E9A17C9" modified="2024-05-29" version="1">MPSTFTDPAGVARDEPLYNVVHNDKKRVAYFYDSDIGNYAYVTGHPMKPHRIRLAHSLVMNYNVYKFLEVYRAKPAVTAEMTQFHTDEYIEFLQKVTPDNMDGFMREQGKYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRDKCDIAINWAGGLHHAKKSEASGFCYVNDIVLAILELLRFKKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGELRDIGIGSGKNYAVNFPLRDGIDDNTYSSIFQPVISAVMQYFQPEAVVLQCGGDSLSGDRLGCFNLSMRGHANCVNYVRSFGLPTLVLGGGGYTMRNVARTWAYETGRLVGVEMNPVLPYNEYYDYYGPDYELDVRSSNMENANSPEYLEKIKISVIENLKKTAPVPSVQMQDVPRQGFGMSDEQEDELDDMDEDENKDVRRTQRQWEKERARQDEFEESDDEDMAQANGVFKPNGPPRRSILDYKNPKAVEDMDLDIGEPAPASIAATAAAAAAKPVEPVAIDNDETMIDDDEVQPAAAEPEAEAPATTAAQPEASSAAKVDEDGDVDMAEADEKPTEPEAEIKTEEIETDPAPEPEAERRPSPAAATSEPATEAAPASPKAASPVPEANTEKAVAEEPSKAAEEASDKVPAATTDDKEKEADKPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMH8</accession>
    <name>A0AAE0MMH8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_311953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677522.1">
        <property type="nucleotide sequence ID" value="XM_062823314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMH8"/>
    <dbReference type="GeneID" id="87860468"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3338071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="279" mass="30548" checksum="3BB0F7850A3A4044" modified="2024-05-29" version="1">MKPRKLSPSLPSANKMAPKPTPPLRSLPNISYTVLVAMVLSLFSHGAHAKPAQPQTVEHLDLIFFAEIPLNCTGSQITCPTQLQCSPLTIPYVRCPGIRPNTCCAVLPPFCGAMACDRAQGCGRGVELALYTGIRDCSIHGAGFGHYYCQQLEAVDEKGGCCMLGFGSNDWEVDPDGVRGGCSAEWWYHSHQQEKRHGSFDTSIRGGQREADGLSEQRPQPCVEASVLAFYDDAGLQREVHVPNGEMGRAGTMVLQRNWKGLLKEFDEWGESFEHSNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMU6</accession>
    <name>A0AAE0MMU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_582073</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677763.1">
        <property type="nucleotide sequence ID" value="XM_062830840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMU6"/>
    <dbReference type="GeneID" id="87867994"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="111" mass="13019" checksum="8998296BEB95AF7F" modified="2024-05-29" version="1">MFTTEQASKASTTPSTSSHERVPPDSVKNATQEILARPSSLFLRLPMEIKLMVYRYAWTVDPEADKYQWQRFVRQYAIEYEYDPLNEDLEDQLKALHTLGSICKKIRRDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MNT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_433093</name>
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    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678411.1">
        <property type="nucleotide sequence ID" value="XM_062825042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNT8"/>
    <dbReference type="GeneID" id="87862196"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="410" mass="42980" checksum="8E7EB8A3F682606C" modified="2024-05-29" version="1">MALADRVNLGPLTTVFTAPAACSTAIFADNKLGWRGQLCVDDGQSITDNTDCWPGTQRGFYSPGLFCPEGYTSACTASAVDGVTSTGWKAQYPLQDGETAIGCCPTGFRCGDLGSEGQTCVLRWGTLSMEQPTAKCINGQLTDFGTMTFPSQKPNLYAGMVQINWKASDRDESATTTTTSANSDSTSGSASASRSNPDLGTDKPAMGKGTVAGTVVGVMMFVLFFPIGWLFRRNRQKKASAEASAEGGHDSDSAADPTRSLVGMAAASRAPGSSAAQTPQPGYADHPMHEAPGDYKPYTVGVYSVSQLDDNKVTPELPMHHEIHEVYAPGANTIPELPEHSEVHGVHVLGAHTTPELPTQRSAYEVAGTAPKGPIHHSVNDAPWSPVDPFEVSATPVDPNRPGSGAAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPD6</accession>
    <name>A0AAE0MPD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Siderophore regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_293935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678589.1">
        <property type="nucleotide sequence ID" value="XM_062823050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPD6"/>
    <dbReference type="GeneID" id="87860204"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034757">
        <property type="term" value="P:negative regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000039">
        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="112"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="281"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="436"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="500"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3339229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="583" mass="61696" checksum="5F11E940C5C51918" modified="2024-05-29" version="1">MALPDDTRLMNNQTSTESNSAPGRTALPSRPPPMTQSNEPPKHESTGPVDEASSKSKSGPSPNSKKAGHAAQSPSGRKKSPKTLYSQPAQSSTETVGVVNVATLGLVPSVQGHAGQVCSNCGTTHTPLWRRSPQGAIICNACGLYLKARNAARPANIRRPPSVMASNVRQAPTKLSPKATAPLLPSNPGATYVAADQTPSGSCPGGGRCNGTGGAEGCGGCPAYNNRVSKSASLDVLKCQGAAAASCKKPQAAEGSGEEPTEVDITALHVQSQNTTVVIACQNCGTTITPLWRRDEAGHTICNACGLYYKLHGVHRPVTMKKAIIKRRKRVIPAAGGETGNEPSEAPDSPPPAPEPPMEKGTVNEDGSVNLGIRRRPVRPLTLVPEDELRRNRQASPLSSADLGQYHSSHMNHGARESLTYENRLAPIHSLALPVDRQSSLSPASFLSPSRKRSISAVENESSTHNDNESHKRLSSIKSILNPMPSSEMHREASPADQLRMQQPSRSPAMSSLTPAPSPGSFSNSTVIGTPTSAPTMRSGSRDPLSDGERLKAERRAALEREAEMMRKLLAAKERELAELGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPK7</accession>
    <name>A0AAE0MPK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_551142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679652.1">
        <property type="nucleotide sequence ID" value="XM_062829789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPK7"/>
    <dbReference type="GeneID" id="87866943"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="101"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="930" mass="101516" checksum="92DFA68375BB752C" modified="2024-05-29" version="1">MEARALEHERRLAESHGQEALKHAIAAAEIYMRAAEKAANPKDRNRLQRKCSDLIALGERLKANAKSATTSARPPVPESTRTLTIAEKTLILKSSKLHGNIFPPWEKTPGPDEFATSKAPDGCYTDHSPFTLSPEQQDIFAGWKRPHEIFVHVPERGSDIFMTAAESIDLGQDLATDCSVVASLCAAIRQFGPRTGSLLSSLMYPYDEDAKRPAVSQNGKYIFRMYFNGCWRKVLIDDRLPTSSSERTLYVVDRRNHHLIWPALIEKAYLKIRGGYDFPGSNSGTDLHALTGWIPEQIFLQNDDIELNETWNRIKSAYDQGNALVTLGTGKLSREEEQTLGLVREHDYAVLDLRNDGNNRLFLVKNPWRDSLVWTGVGSTATLSTDRSETPEESMSNTFWMTFEDVLQHFDSLYVNWSPSLFRFRQDYHFTWTIPPKAEELVFTQNPQYSVLSPTGSPVWVLLNRHWQDSELDILRERKQEHGFHQPLKSLGYMSLSLFTSHPPGTRIPLSEGSHHALHQGPYVDSPNTLLRYSPTPGVAQTLVIAQSDLPLPSYSFTLSFFSNSPLTISPASDPLPYNETITGAWTRRTAGGSTVYPSYVTNPQYALTLTRPSPLSLVLSTERADNLPVHIAVLYSNGGQRVTAVVGRDLICSSAEYQRGCTFASTLPSSNTSANTNTNTSSTTSSSNHGGLIDPGTYTIVLSTYEPGQTGRYSLRVSAACPFTINPILSDAAGRLRTPAPPLPTTSGHNNGNSTNGEARVVRARVDVIRLTRASVLARSVKTQSTTMVRVALELGTIEGRKRVLVSTASGGGGELAASLSSLSLSDRLGGIGGGHDGHGTEGSEGYTTKGEFADASLGLRTREVDLDPDVIRSYGGLWLVVEQIGGGGGGGGGNQGQITEEGEGGGVHVEVLSDGVVNIGAWEVADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQC3</accession>
    <name>A0AAE0MQC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_267437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679624.1">
        <property type="nucleotide sequence ID" value="XM_062822702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQC3"/>
    <dbReference type="GeneID" id="87859856"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="35495" checksum="144263C9A00AB336" modified="2024-05-29" version="1">MEDKSTRAATNAPELAAWEHTHQGIERAPSPQHQPSLQQLHHPEGQPGLEPAPHSTLEVSPHQVQDDKLSSYGPTSTISSTSPYPAYVLPQPYGYSQHGNIGSVPGTSTIAGSTAAGGGIGDKEAGNGDGDDNGKNKRYCFGLGTKRQVAWSLLAIGIFLIVVGVAVGVGVGVSAGKGGGKKSGNSSSTATPTSTTAHPSWTHTANLPPPTAYATITPSTSIICPSNNLTLYTPSNDTILSSSSRGKGYLLLCGRDYNALAGADDITNREADSIETCIDRCAEVDNCVGAGWGYYDGKQICWLKSRLGKPGWTPGWYMAVREDAVLHDGSEGGLSGDTETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQT9</accession>
    <name>A0AAE0MQT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_590014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680867.1">
        <property type="nucleotide sequence ID" value="XM_062831053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQT9"/>
    <dbReference type="GeneID" id="87868207"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="85"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3343074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="503" mass="55412" checksum="39C66DB0FF9FACE4" modified="2024-05-29" version="1">MKLPRAALRQCSRHLRPQNNRPLQPRLQSAKSIIPASSSLSTPWHPSRTYATTTTTVSAADLEFGQPVYETHPHMLQPGELTPGITAQEYHERRSKLAFALPENGIAILASSELKYRSGAVFFPFRQDSNFLYLTGFSEPDSLAIIQKTGPKPGDYVFHLFCRPKDPRAEQWSGPWSGLQAAEDVFNADFTGDIAKVETLLPPILRGASKVYSDITPSTPVTGSLITTLLSHLHLPPAPLAGLVHSLRAIKSPAEISNMRHAGRVSGRAITSAMRRSWSSEKDLESYLNYAFTSHGLSGPAYVPVVAGGARGNMIHYVHNTRLLKQDEMVLVDAGGEYGTYITDITRTWPVNGKFSPAQRDLYEAVLTVQRSMVSLCRENVSLSLDQIHRATEAGLREQLTLLGFDLSGGGKMDVLFPHHVGHYVGLDVHDTPGYSRGLTLRQGHVVTIEPGVYVPVDDERFPEHFRGLAVRIEDSVVVDVESPLILTTEAVKEVVDIEALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR46</accession>
    <name>A0AAE0MR46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH/ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_551260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679790.1">
        <property type="nucleotide sequence ID" value="XM_062829798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR46"/>
    <dbReference type="GeneID" id="87866952"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="124" mass="14868" checksum="F799980E5718C1BE" modified="2024-05-29" version="1">MPITPTKYAITTRQSVNWDDAKRRVFALYRRWLRSTPEMQSMYSLPLPISVIRTRIRQEFERNRFVNKLPVVDVLLTKGHADYQETMNFWRQTTHMMSYFNEESFRGAKRLPSSFIDGFLQGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS58</accession>
    <name>A0AAE0MS58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_189804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681544.1">
        <property type="nucleotide sequence ID" value="XM_062821626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS58"/>
    <dbReference type="GeneID" id="87858780"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="155"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
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        <source>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Gladieux P."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2" key="1">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1239" mass="137247" checksum="FC2E389B553410B1" modified="2024-05-29" version="1">MNPFRRAPEAQGEHVSWRSNTTIIPDDVIDPELLAASNRNVVADQPTLLQQPPQLLAESSQGNNVEQTSVYQHPPLDVHQSHPQRNPFSNPRLNPQFNHQPNLHVSSPSRDGSLYQHPQLDVRQSNPFSNPHANRQIIPHFNSQPNPQPSPQGHSPPRDESVYQHQPFNPFALAYSPPQDGRTFFQQPAASHSLTSHLNPMSQGDAPASPPPGTSHLQQDSFVRANIQSPVRSRSQSFSRGFGQGPMEMDDSPFPFQAEADSSPLSSLAATPAVASATLAMDLDDWEPGREAQVGIPSSSPPRNNATPKRPRERQQEDLQGREGQYQRPRRYNIDVLLSSVSIAPVAEMEIDQGVAEGSTASAAASHVDMESTSHDPSLQRPGSQENARPRATTLEIGTALRDDILRRIRPGISFPSGVPYSTRYSEYTQPPEDFSRPLGSARPMPPPENLPSEHGRSLSDVGVNRIRNVSGPQTGESSRHGQHLNSQAPGPSTSSSAAPQVQEGYPSHESYTEGVLQHMRAATPGPSGSASTAPKNPEPALSGHSLAGLVQGALQEASVNDVVTAAHAILNQHRGSTQNQYRQILPAPTTPMEIDNRSSHQPTERLQQRDTQSDDQVQQQDMDPTEHQSHQLPFTNMEQFQPIPAPAPTIRSPLLISPFPLRIPDSFTPAILSLAIDPPRSLQIGTTDSLRSYLRACGIVPYNDLYPRTIPDVPREPFNRTVVVEARYLSVIGLLYPRAEFIVSRIAEGAEEHMEGNTNYNKKLEPNAAMMMEKWHVYKAVRMTGEEMQKLGVCVWSEKGCGEWEPVVEEARETKRVKRTEVVVVDDDEEEEEESDDTVVASGKAKEGAKNENTRPTVEEDEEADEDVEMVDVEEEVQTSKKRKGKAKEVEVANKKGKGKEVLQEKDGSGNAAAQPSASKASAPDPASAPLRRSARVQSRQGSAAAEEANSDRDESKTKLIITRKLRAIQLDEAGESSSAAAAAAANPSRPIKTPKPRLTTTKAIHSVTEPADPRAAYLREASTHYLITLRQRDWPSGGVARIQCTPKARQTIEYIQESFGIQSPYEVWRQKDYRVWNGDTGEVKRRYIKVMRGYAGDENTEDGVMRLFLDEMDRRMKEKEKRRKEKGKGKMGEEETGDGKDMSTLEERKAWKESYKALKRRGKRAVARAKGKSKEGEDIDMDFDEWLAVRREEENELCERWFKEREGLVEEEEVDSKTVEFALFEYGGGDGLGLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSL9</accession>
    <name>A0AAE0MSL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dock180 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_213684</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682386.1">
        <property type="nucleotide sequence ID" value="XM_062821969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859123"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="586"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1415"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1766"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1842"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1946"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1992"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2058"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1775"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1843"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1876"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1953"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1992"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2061"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2090"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2114"/>
            <end position="2135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3345773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2169" mass="240550" checksum="8FFAE9CBAA876202" modified="2024-05-29" version="1">MPWQPLPRIAFAVATYPFTASSAADLPLEIGDELYIIEETPDGNWLRGYLVAPPSLLAGLTSVNGQTLEARVFSGIFPRSCVEVREVLGESDETDDSEPDNGDPNGENKKRRSKRVTKEGRLSVPVKRDPNAPRPPAPVPMLKIGDETPTSAAEPLIDEIASCLREWHSTNLHGLLLSRQYEKLDTLSKLITSLNLSRQQFLHNVLTTWEYENLREKTVWDLVRVNKLCGGEVIVRDPSARGRVMTGDDSVVEITQLQSVMSLLDEPPTTTLELTALHHLMVDIKCFAGASNESTTLVLYLATKAPGGRVTPLSESYIVDVPAGGQLTNLARTSQMRTLFSDLSSADIGDVQSSKSELLLVVKIRAPQPVVAAKPSSRSGGPSNSSPQISAKESKPPLVSGNKALRRSMVWANKNTRGAFARKNSDLEALSEQAEEQQISNEALESREGAPPSTANSRAGRPSVDGQFPPTTADRTVGVGVLKLNSIMKQQGEEVEHVVNIWAPCSKFPSDRHGENSEEWDPLIKEICDSRSGHHERSRRAERLQIRLRSFNNPDADALIKMTPTVLSGICKTNKMGFSGAPTKPRSDIYVTIDEATLTRQTLLSRYGASATSLPSSIHGTNFQITLEVRRANGERIDYCIYPSSKNEGLSTWRSTAVDRGDPWKQIIKLVLAPQDVHQSHIVMYLSDAPNPPFAVAYLPLWDQQAFIHDGSHNLLLYKLDENTSSAQAPAGGKGGYLSLPFASNFRDEHAEVTGPLAVLRIDTYLCSTRFSQDKVVLGLLKGKDLPQGEVPDILKAFIFVPEIEVVKLLNDVLDALFGILVHYTGNDDLEDLVFTALVRVLDIVHDRRFNLAPLVDQYAETRFNYPFATPCLVRSFTRLLSKPTEPETSRKLRATFKVVRHILKFITHARGQQKEKEAGIGITTSNPGFTRHLRTIFKALDALMRNQAPVLVGSQTLAVQHFHTWLPELTGLLTTEEILHIAIDFMDSCSSVKGKLVLYKLVLIINYSMLDIFSHPEQRSALSANTVRWIAPHWGHTDEVTEQWREQVRLCCSVLASQVEHLGPEIPDYIPKIIQSYLAIQAAEKTPKNRLSLLFPTSYPFPAKPTAEEVVFDEALIELSAVLSALSNSPSGMQLELAEDDLNAIIENCLRVHMSILQGETFPSNWLSVHIFHHKSTMRTLQYLATLLLESFLPHPDEAENFDTELWKMFFTTLLKLVGSPSLALETFPEQKRRAVWKIAGDVREHGADLLRKTWEAIGWETSLEERARYGLSKMGGYQVQYVPTLVGPIVELCLSVHEGLRRMAVEVLQTMIVSEWTLSEDLSVIQTEIIDCLDGYFKEKPLTESILQKLFVSELLDRFEPLSKIPDEPLYTAIRELMGTVDEFLDLLVAVHSGDGSGEASNLIHRLRLMEFLRDMQKEEIFTRYVHQLASLQASARNHTEAGLALRLHADLYDWDPLKTTPALDDPCFPAQSHFERKERIYFDMIKHFEDGHAWSCALAAYKELQAQYESNIFDFAKLARTQRAIATVYETIAHKTDKLIPKYFKVVYKGLGFPPSVRDKAFVFEGASPTERTAGFTDRMQEMYPSAQIITPSHERDTAEYDVEGQFLIISAISPHRDLTHTVFQRARVPQIIRDYLISSSPQTFSISTKRDTNGDVRDHYAEKKIYTTAEPFPTILKRSEIVEIKHVRLTAKETALERIVRKTGEMTAVEKKVAEGQAQGGEGSDEATVMLLVDAVSISVNPESEASVSRYRELIPGMGSTTPITIKCGSDEDEDEEDGPPEIDAQENAIKMALVDHAIMIKRCLATFAKSPREVVRKHGEDLQRFFEQTFAPEIAIFTPPPARSPQPSPGSDRTGGITPSPTWPRSPAAFGSSTGQHKHQQFATASLANGHGLGISGNAQGHAHTASEAADVLGEIVVVSTGISQPVSLRQGRGARLSFLGGRKKDGNSPTTHQLSSTGSIPHLLNTSDHNLASRSKSHEDIYAGSASATMMNTPTTTGDRSPSVPNNVVHSRKEQQQQPIESIGKANRRSFLRGFSSSDKVHLVNAINGAAESVGGNTDWQTEYSSPSLSQPNLHSPAQSQSDQLDREREREAAAAALNGYGKKEKKSKKEKEDKEEDKDLRELKDKFHNGSASVKKRLSMLKIGNMKKSGKGDGKMGALDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSQ6</accession>
    <name>A0AAE0MSQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trichothecene biosynthesis enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_155253</name>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682847.1">
        <property type="nucleotide sequence ID" value="XM_062821141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSQ6"/>
    <dbReference type="GeneID" id="87858295"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MALA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mala_s_1-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="376" mass="41466" checksum="1F36AAED460974EF" modified="2024-05-29" version="1">MLRNFPILGFALASVLEARAWPNLSLLPSSNSILGIGKHKECPPFNKGNFTIDYFQLYPENADWDAHSCQVIFGSLWNGSVAIYNPYLSQITQSLTFPGVTNTGTYHIGGVAFDPLSNLYTILTDPAAAWDTEGGDLRGDHLLIKYNPITNHTLWTLNLTTLTHERYGGFQDVETDRRGNTYVVGTFPGTILRADKHGREIKEWYLPDPFPTVTPGTPFAKGGFGGLAAVPGTEILLSNDGDGQIYRFDMRADRGHPVAVPITPKVLYNDTDAIYLPPKYGGSVLLVASHGSGVQVLRSRDKRWERAEYVGTVEVEYPRDEEFPQGEGVTVAVTQIGPSGLYVILGFGDLPWVEERWRAGGGGFRCRILRGKLKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683046.1">
        <property type="nucleotide sequence ID" value="XM_062824462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT86"/>
    <dbReference type="GeneID" id="87861616"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="93"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="358" mass="39853" checksum="8826EA80B4297F65" modified="2024-05-29" version="1">MPCQCKACLDQLASPQWLWFHEQQHHANHKILACPHCDTILPTKAKYFPADNRKLLGQLLRCPSCNRQDHLHLFLRRQTAFACGFCSASFHSSSSSSSPHSSSAAKTTPSSSSISSPSDSHKRAKRRFFTHLATELARNDELIEQGQPPREWSRTNVIYGLLQRPGIVKHWRALVVGSKDKEEGKDGGGGAADMCMIPPGLDAFFSWDNVDALVHTDMDTDTARVSGSQLEYFDPVKDGDAKAAKLAELAFEQADKVFGYRAGRVETKIRRNDPGSVGNQSDEKGGGEKKVDMDKPLPELPTGATSSSSSTVQPTGLRSTDCRRNRDRRRREDEDNKTRRRVRNVVKQIEMALSAAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT90</accession>
    <name>A0AAE0MT90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LIM-domain binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_204478</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681995.1">
        <property type="nucleotide sequence ID" value="XM_062821847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT90"/>
    <dbReference type="GeneID" id="87859001"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="462"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="573" mass="62937" checksum="CC93F1F29E284516" modified="2024-05-29" version="1">MQQQQQQQQQLQQQQQQQMAQQGNNPGQHPINPQGPGLNMQAQLAALHTQQAHAQQSAAVQAAQAQAQAQQGGPGQPQQQQQQPQAQPPQQPPQQQPGQPQQPNQQQPQVQPGPGVNGPAQNQGPAQGPTQQPNAQQQVSPQTPQTTQAQQAQLAHAQVQAAANVASLLQQKRVDSANLKGQCLLKLNLFNEHLNGFTGSQGADGLKYWHHFVQRFFSQKGVFRQTFKKREDEAADPKPYEIDYAALPRFFNVHFESGVSKMQLVTQGTTDRSMPHDGHFIEIAKASVFYWYDNGSHVVHNGTLRIQFDSDQNIELFDFVVENHEEYHSRRAIIEAARPSHTWIKEWRSLNPPDSKQSPEMSKKGKQRPYKSPATPPPDIELPDSCVKIGMGIPEGVFQFLEMADIIGQMNPLFTFSHSHPGISPYAALEQYMTQITGQGPNVNGQAMPQGVPRTPGYNQFPMGASPAMANQMLPGSPHMGSPAPGQMQAPAMQLQVSQQGTNSSGPSANTSPQQNNKKRRASQAKLEDDGPTSAPTPATIGTPQMPQMNGVQVKAKHPPTPRMQKRMKNNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTI7</accession>
    <name>A0AAE0MTI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_536879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683838.1">
        <property type="nucleotide sequence ID" value="XM_062829061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTI7"/>
    <dbReference type="GeneID" id="87866215"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="266" mass="29473" checksum="E06D35EEEEC37BB7" modified="2024-05-29" version="1">MTMTNKTLRVRVWGDQGGWALANLEWWCMQVFIFIGGLHLLRDNFSADTSFFKVVFAAINANFQFAKFKNTATKTSAATAECRHRQFKLRQFGRTSAVYHDTHRLPLRTSSALPLPTQAFQAQIVSLVRDHQRPQPPLVKQAVRSQERVPHPLAHVSTHHATLKSSLSTESEVSTPQAANKSSPRRPSRGYDLTNPLSPEDPTSSGACTDSDLTAAVTTLVEVPSSRVIQHLMNDLPRKKPIPSDIQLLPQQSPFDRGAASGDCAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTM2</accession>
    <name>A0AAE0MTM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_443059</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682355.1">
        <property type="nucleotide sequence ID" value="XM_062825612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTM2"/>
    <dbReference type="GeneID" id="87862766"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3345742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="449" mass="49971" checksum="603BB523567152D5" modified="2024-05-29" version="1">MREIISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAADPDHGFSTFFSETGNGKYVPRTIYADLEPNVIDEVRTGAYRGLFHPEHLISGKEDASNNYARGHYTVGKELIDHVLDKVRRVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQTATSVVEPYNSILTTHTTLEHADCSFMVDNEAIYDICRRNLGLERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISAAKAAHEANSVQEMTMSCFEPNNQMVKCDPRHGKYMATCLLYRGDVVPNDAHAAVATLKTKRTIQFVDWCPTGFKLGICYQPPHQVPNGDLAKVNRAVCMLSNTTAIAEAWSALSSKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSMEGEEVEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTM8</accession>
    <name>A0AAE0MTM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_571512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683134.1">
        <property type="nucleotide sequence ID" value="XM_062830484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTM8"/>
    <dbReference type="GeneID" id="87867638"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3348052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18498" checksum="D8034D70EBF35E78" modified="2024-05-29" version="1">MASTIAAATKVSRTMFRELHGVVVTSGLIDKTVKVRVGGQKFNKFLQKHFDDPKQYLVHDPNNSLRAGDVVAIMPGFITSKSKRHVVKHIIAPAGTPIEERPPIPSLDELWDAKDAAKEAKKERKVLREKIQAAEEAIELGERMARHAEREIAMREKIISLQKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTQ0</accession>
    <name>A0AAE0MTQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_424232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682445.1">
        <property type="nucleotide sequence ID" value="XM_062824501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTQ0"/>
    <dbReference type="GeneID" id="87861655"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="620"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="984" mass="110869" checksum="D9530DD202C538F2" modified="2024-05-29" version="1">MSGQKMTLPTRPAGPPQSPTQARSPSGASAASGAAPGQARSNFPPPLGYDPGKMDTRAPLSHEERVGKRVDLPADAYTGSDISSTFAARTGFNTEGNSIRVAVNQYPVTRIANMDVSQYDIALSPEPTAGVVYDKVWKSKKVQQKLASVTNKPWIYDGRKLAWLAQSVDEMRVMVDLDEERGRKPGGERKNVFHITIRPTGKVRLQSLRAYLEKRAPWDNHVLECMSFLDHLLRQGPSERMKTIKRSFFHASMPNRELDMLLMAYKGVYASFRLSQNIKQIGLGVNVDVTNQAFWKANTADKMMKYVINTYGGLRGKGNMQNLDDQLVTSALKPLVNRTTGRYEQSEAMRALRRLKGCRFTLVHRPNEVKEYKIKGFAFDKKYGPDGANSYNVTFKWNNNGTEKEISIRDYMKERYGYALIHSAGWPVIETTRAGSFPAEVCNIVSFNQYQYKLDPNQTASMIKFAVQRPAQRKQDIAASVQRLDWANDKYLKAFGVSISPNMAITEAKVLRHPEVFFEKKTVRPLNTGRWDLRGARFVEGNKEPLTRWCFFALNGCVDQKAVVNFVGSFVTTYKGHGGRIAPGNPYMTNVTANPATLNDELHKHMGTAVGGYKNLYPQIVFIVVPDKTAHVYERIKKVFDCRYGVVTQILNADHVRKAAGQYISNVCMKVNAKLGGQTSSLTATKAKSHGFFTKPTMMIGVDVSHASPGSDMPSIAAMCASVDMEGYQYRAAVETNGWHNEVLTNENIETMVPKFLQAYKDKTGKEVEDIYYFRDGVSEGQFAHVIKQEVEAIKKVYMARFKGQKKARVTVIVATKRHHIRFFPEKGDKNGNCEPGTLVEKEVTHPFHYDFFLNSHHALQGTARPVHYHVLMDDIKPQVNTLQRMIYHQCYTFCRSTTPISLHPAVYYAHLAGARGRSHESLDYGDNARVPEKVREQVNNPDNLVAKHQSPTTYSSEWKKSNPPPKLTVMEGKNHIHNTMWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU07</accession>
    <name>A0AAE0MU07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_419222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683766.1">
        <property type="nucleotide sequence ID" value="XM_062824194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU07"/>
    <dbReference type="GeneID" id="87861348"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3350471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36791" checksum="C6F101F5A1FE8C3B" modified="2024-05-29" version="1">MTTPSKSPPSPSSFPRGTFPLSGKTALITGAGHGIGRFLAFAFARAGCYVACVSRSYPLGPVGSDPDSDSSSHTIAELINASTSSLDFPTTPNRARDFICDVTSPSSFAQLELDIRRWVNQPVAVLVNNAGVARVEGIEFQTPLLVGRKGPEGMESWNKVIATNLTGPVALTYQFLPGMLAAGEGCIISVGSRNAVVPVPFMAAYNVSKSGLLKFHETLEREVGGRGARNFFVVPGNIETGILKREDSVDEKSYRESARVRNMVDRIKEAGRRGEDAETRAQEFAEVCVRLAAMGKDADILSGRYVDAERDVDALLKDARKGTESEICKRRLYQLKVDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUA7</accession>
    <name>A0AAE0MUA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_507985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683105.1">
        <property type="nucleotide sequence ID" value="XM_062828191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUA7"/>
    <dbReference type="GeneID" id="87865345"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF130">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="317"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3348023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="598" mass="66112" checksum="C8231CD992C7AC8E" modified="2024-05-29" version="1">MGQVLSEEKPAPLSHEELVKELANIFADKCFTSLELYSLKQVFKSLAHHEQRVGYLKEGTIAKYLKVPDILGISPVLFQMASYIAAFPFLEDAPAVLGLEQMVIVITLMTDRYRRVLGKGAADKTKLLFKSLAVYDRKFSKSAVDTHSGSSNAREQIENDGQGLDNDELVLAAFDALGHVNPDKLQNMPATHGPMIPGDNFRKFIMLLLLVAPLDPQDSLDSDPDRVTGAGLQSLRTAAESILAAFLDVERNPGVEYLRFSKVIAGCLPFLFQGLAPLFEHFLFSEELDFHKGKDGTSRSPTMPPEPKQPLLQDTGSIMNASILSQMSFFIPGSLLFRRLRLLYAGDEDGFSMGSFEAKVFNWKTPTILLVSGTRLLDESDHHSNGSAPAFWASLPPRRFSRGSSGEAERLTFGVYVPEPWKLTHRECFGGEETILFQLEPIHDLFRASSLNKDYVSFTRPSASTSHAGVSFGCPPPRPSQAYRRSGMIPLGPVSLMLDSSFEFGCFTHDYASKGGAFQTSMIREYNFQERFEIGSVEVWGCGGDEEAKHQAERWAWEAREAEARRRINLGTGDIEADRALLEMAGLVGSNRSGGSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUM2</accession>
    <name>A0AAE0MUM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear protein SNF4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_127693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684917.1">
        <property type="nucleotide sequence ID" value="XM_062820764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUM2"/>
    <dbReference type="GeneID" id="87857918"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="188"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="266"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="336"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3351622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="401" mass="44688" checksum="AD66769E5EA7A92A" modified="2024-05-29" version="1">MDDSRTPPDQAASGTGSDAASASAQASQPSTTSAGNSNPDPNLNGPLPLRPGHELPFVAPSSYLRPKPSSRTMSDKTSNPLDKDQMQGLRGVREFLKVRTSYDVLPLSFRLVILDNDLLIRKSLNILIQNGIVSAPLWDSRNGTFAGLLTSTDYINVIQYYCQFPHEIDEVDQFRLSSLRDIERAIGVPPLETVAVHPMRPLYEACRRMLKTRARRIPLIDTDDETGRETVVSVITQYRILKFIAVNNEQHTMLLKKPVREIGLGTYTDLATATMNSSVLDVIHLMVKYNISAVPIVDKDNRVLNLFEAVDVIPCIKGGAYDELTATVGDALSQRAEDFGGIYTCSEEDRLDTIFETIRKSRVHRLIVVDDDSRLKGIISLSDILKYVLLYGEEEDDLQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV32</accession>
    <name>A0AAE0MV32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HCO3 transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_568829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684906.1">
        <property type="nucleotide sequence ID" value="XM_062830403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV32"/>
    <dbReference type="GeneID" id="87867557"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="69"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="244"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="692" mass="75201" checksum="ED65F61F5FADB9CB" modified="2024-05-29" version="1">MASTTKPDPGPGPGDSSSFTLPGSIPGAGAGAGAGAGGLHPSHHNPGFDRESGTGSHKTPRPPKWYKIRLFRGMINDLRRRAPYYLSDWTDAWNYRVVPATVYMYFANILPALAFSLDMFTKTDRMYGVNEVLLASVLGAVVFSLLACQPLVIVGVTGPITVFNYTVYDIIMEHTTGGTNYMAFMCWIGLWSLVFHWILAVTNSCNWLRFVTRFPCDIFGFYVAFIYLQKGIQVLERLGDAEPFYLSVVVALCVFAIAYICGELGDGSLFNHTVRVFLKDYGTPLTVVFFTGFVHFGKLENIHLEHLEVSKAFSPTPHEDGWIRGWFIHFWDIPVGHVFLAIPFALLLTILFWFDHNVSSLIAQGTEFPLRKPAGFHWDLFLLGLTTGVSGLLGIPFPNGLIPQAPFHTTSLCVTKVVTNDDTDADSSEAKGHPSESYEFKPISVVEQRVSNLAQGLLTLGTMTGPLLIVLHLIPQGVLAGLFFIMGYQALAGNGITQKLVFLFKDSRLTSPNHPLNNKALRRSRVWLFVIIELVGFGATFAITQTVAAVGFPVIIFALIPVRAVLLPRWLSREELAVLDGPTASPFTMESVGGSYGGVEDEGEEEGESSGGGDEGSGGVLGGGPSSATGRNKSKKVAGEKSAEELAELGQSRLSVGSGRSSLRRGSTAVDEIQQGQSQGQVHRRGHHQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVH6</accession>
    <name>A0AAE0MVH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc knuckle-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_106913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684335.1">
        <property type="nucleotide sequence ID" value="XM_062820500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVH6"/>
    <dbReference type="GeneID" id="87857654"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="285" mass="32446" checksum="831DB68EA8D37ABA" modified="2024-05-29" version="1">MYRGRNIPSKSTPSAVQCQKCLKRGHYSYECKASAAERPYIPRPSRTQQLFNPKLLPKLTSAVPPQDKKGVADEILAQREAERAKKKELERDDESPSRYVSPRRSRSRSASVDSVSTISTRSPSPRPSRHSRSPPRRAHAQDFFEPPPKAPSARQRSVDSRDRYSSRRSESPVKHSSRKGSPPPRRRSPSPRRERGRERGRGSGRARPSRRDYSVSESRSRSPVRSPVRRDSKGENHRAGGYYRDRASPQRPPKREPSPPPPPRERSLSPFSKRLALTQSMNMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWT2</accession>
    <name>A0AAE0MWT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_585397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687153.1">
        <property type="nucleotide sequence ID" value="XM_062830923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWT2"/>
    <dbReference type="GeneID" id="87868077"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="149" mass="16784" checksum="5CF66E4F6BCD8254" modified="2024-05-29" version="1">MSDFPTYTKPFNKNAYRSAAAYKSHLESQRMKASPISHQAPRTITRPTPRPTLRTVPRYRAPRALASPKLMTDEEVRAWFREAEEEYEAKKKAGYYDDYVPAAGPSRAVLANTTNSLPKRKTGLENSMHAPKKQSITSTPAFAAVAIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWY8</accession>
    <name>A0AAE0MWY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_451730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686734.1">
        <property type="nucleotide sequence ID" value="XM_062826071.1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="12"/>
            <end position="33"/>
        </location>
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        <location>
            <begin position="40"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3355356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823791.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <location>
            <position position="67"/>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062827875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J169"/>
    <dbReference type="GeneID" id="87865029"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="111"/>
        </location>
    </feature>
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        </location>
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            <begin position="31"/>
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        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="427" mass="43982" checksum="C88B03E32270D543" modified="2024-05-29" version="1">MNRQVVTSTLGRRGALVDCCTRASSSILNTTQRPFSTTTTRCAEDDKPSASKSAAAPRAPGPVSASRQKSEAAVGKLTQLRGSFTSLSNDNSFHKAPPAGAGGARDARRPAAAPIGKGAKDAVAPLGASGAPKVINVRSLKGTLGGSRGRFAPGGGNVPGAVAPGAALRPRFGGAGPRSAGAGPGGAPGRPRFGAPGGPGARAGAGAGAPGGAGARRPGFAARRPRPAGGEKKFRGEDYDAPPTEEEKEFIRGLEQGKVTEYVPKLTPDTLLGYGPPMATDVNLGKVESALRTMRILGGGLPFNDQSGVTSDPTAVKHRYVHEKKPVFFSSVEEKEWLSESLDKFAVSQGPEKKTKMQILETSVLGKYESPKYVESLTDTVAMVEKYQGGTFSYAPSDAVKFKARLNALLAAGQPRAAPPAQAQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1S5</accession>
    <name>A0AAE0J1S5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_446869</name>
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    <organism evidence="2 3">
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676762.1">
        <property type="nucleotide sequence ID" value="XM_062825820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1S5"/>
    <dbReference type="GeneID" id="87862974"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="475" mass="51334" checksum="B180EC2BB0F4CAA4" modified="2024-05-29" version="1">MADEGHYSFFEEAFFNRHEPYELLYGDNDNDADFADRFGYEGEWGMDENDFASIQRNSSLEPIDEPFLLQEGGLGAAEKSSVSPLKNFSSTFHNALTPNLEDAAIILNSPNAAPEPVAFSKDKNLITKDDAVSFGDDSSIELDNLQHVQFSNVDNQYRVDTTAHTSESVLDNSITSNSHTTPGLDHEIKRSETAHASFDPRGAVNSQCTMSDPEHDSLMVEQNDHSINVDDHNASSLEGATCNKHNIANAYIDQSTKTNTDTHTKAVSSGVHNAVRRNQHQPQGETVTPSYVEAVCHKFAALDVKDGLDRPVVNASNATPVPACFLVPIVSSDQCGVTTTTDGVQCADKGRAQRERRARLAAEAEAARALEESQAQDGIEQTQPGVGQAQQGHYQAQQAGNHTSPQQDNLPAQQDVPQDQQANPQSQLGTSNGQAGVEPVHSMPSSSRSARGSSILTGKGVTSGRVQKAHRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1U2</accession>
    <name>A0AAE0J1U2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sphingolipid long chain base-responsive protein LSP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_480537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677143.1">
        <property type="nucleotide sequence ID" value="XM_062827586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1U2"/>
    <dbReference type="GeneID" id="87864740"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="374" mass="41589" checksum="CA4E0BDF85EDEA71" modified="2024-05-29" version="1">MHRTYSMRASRAPTASQIQNPPPPPSSTKSGRLFGRGGIGGLGHALRRNAAGAFGPDLAKKLSQLVKMEKNVMRSLEMVAKERMEVAQQLSLWGEACDEDVSDVTDKLGVLLYEIGELEDQYVDRYDQYRVTMKSIRNIEASVQPSRDRKQKITDQIAQLKYKEPNSPRIVVLEQELVRAEAESLVAEAQLSNITREKIKAAYTYQFDALREHCEKVAIIAGYGKHLLELIDDTPVTPGETRPAYDGYEASKAIIQDCENSLTNWVTQNAAVSAKLSTRSRTLSQRRRNNIKARTEGGAGQGHDLSGQDAPLNDRDSWVPANQHKEVAEDYDVSEEEEDDDEDEEDDIDAPGSSLLDGESGHHQRGRNQEPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7C2</accession>
    <name>A0AAE0J7C2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_307532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677371.1">
        <property type="nucleotide sequence ID" value="XM_062823239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7C2"/>
    <dbReference type="GeneID" id="87860393"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3337920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="482" mass="51710" checksum="479DC430C3DEC9B2" modified="2024-05-29" version="1">MEALRNLEFGIPDWLHRLDELNGQIEQRQQELAQLTESKPSSPGREPGSPSRKSLRNKGSTESLRPKDEPSAHPNYKEDETTDKRPTSPQTPGSPGALQRTTSQVRAAGQAKARATLRKRQRTDSVMSAENADKPPKYRSRSMIIVYYDSYVQSFFEELVKFVSASRNMMRKAKMAAKVAQIKRLAELNTPPDDDDNGGDAANGELVPDPKAVNNIDASAAALAAENLDPVQAMLAARRARDQVRMLAQGGGVRANPLAGIRMSAAMGRAGARQPPQGAGPDVYDALDNGLEFVQSMCEHAAHQFLRDGDCGEEVTKIKQRLSQTKDLASKEMERVRREDLGGDGSGEPVAGGAAGSMPRGGTSVASAIPMGMGARSYRPQSMRRVTSVKSTRSSVKEAAKDSVVVTVVEKGVKRTAPATESEGSTVSGSVKGDAKIEVDEGLEDGDASAANDGIIAAVDPSADPEPIDISKLVYRSTRLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7K5</accession>
    <name>A0AAE0J7K5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_581479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677473.1">
        <property type="nucleotide sequence ID" value="XM_062830818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7K5"/>
    <dbReference type="GeneID" id="87867972"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="211" mass="24246" checksum="6FED13D1511F68F3" modified="2024-05-29" version="1">MKEVKVARYQDQIAELAEFVDSVLDHEDEDMPHEEELHVVKQKLSEVKTFLEDLRMDKARSASGHQSQQIVVVCKGCISQFITNPEQLREMGIEEGSEEEAEFAEFAEWLWKQVWEEEVGKSGYTSLHDVASDLNSFVSPFSEYLFLQDANHMLSIERLKSVTASQNGQATILPKSDMAYQNTNEAKRNAGDHLPTLRRWIDSLGRRLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8W2</accession>
    <name>A0AAE0J8W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_579582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678148.1">
        <property type="nucleotide sequence ID" value="XM_062830767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8W2"/>
    <dbReference type="GeneID" id="87867921"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="409" mass="45046" checksum="63360A6F77ED13DF" modified="2024-05-29" version="1" fragment="single">MDPPIAPPPRQRYITSQAHFYQRKAEKEAAAFNAMVPGNFADFPTRATDQCFLVDQMMAAMKDTTDILDNPDNNAHINCIRAKSDDDLEEKAWEAMFDAYDAQRGKRVHKLLTAYFPNFMDRWEALVALMRTKLSNNHTNKMRDFNKDVKAASKFGGSVTTVDRITSVYDAAGNLVRAFVRPEKRPLSDFLGNRLAGIAKPKRARTRAATGDSTISVPASSNSSNSEQPVAGTAGGPMTPIQEEEEDDHAMAAIHEDEEGVMATTQGKEEGAVGEVEKDDGYEALEGPNGLSTPSPDAFNPHFNNQYPTPTQHLPLGEQSNIANQHPIYPTPDQHESLGEQSEQPSPNGYTVPPNNEMDANPFPLSAEAHHEPIASHHGEDVGIQAALDGRATNNGHYLYEVDLDWYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9Y5</accession>
    <name>A0AAE0J9Y5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ammonium transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_540883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679060.1">
        <property type="nucleotide sequence ID" value="XM_062829164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9Y5"/>
    <dbReference type="GeneID" id="87866318"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF15">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="178" mass="19301" checksum="AA2C708D41E2A2FA" modified="2024-05-29" version="1">MSVPVYVASLIGFLTSTSCYYAVKYKHLLSVDDGLDIFGLHGVGGYVGDLLTGIFADNFVPALDGVSGSSYAGGWWNRNFRQLGLQFAGATTAAAWSFVVSCILLFIINKIPGLHLRASEDSEIRGLDIKYLEDVDEEGFYMNECILHGRTPPRCSGSLKAPTPVMEPVSVEGPEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAE8</accession>
    <name>A0AAE0JAE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_257754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="ZIP"/>
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        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zip"/>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="424"/>
            <end position="447"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="131"/>
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        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3340390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="514" mass="55807" checksum="93C25D0B96F46D6B" modified="2024-05-29" version="1">MSATMLTTGIDNDTRGWIMTAVSGLACMLGSTIICIDVPIRFFNIKSKFSIQESNVFISGSLSLSFGVMMFSALFSLLPSALRYLTKDGRDEKTAGLINMGCYIAGFFGIQVVSRVLHRFIPSHVVGCDHSHSHNPHANAHDHHHQPPWASRTHGQSVRTLSSESPETPTMVEANGHATESTPLLPTETDHEAQPNSPVRPNPLGHSHAIGRQARSTTGIQSRRPSVRQMTSRVLSFVKDTKVHCDGDGPCFGYTDPCGQECFRHIGTRSNQPGRFATFPVIRSGGSVGTGEVPESLNGPIYQVRSRTISRDSSVGYADHADYDGHHDHHEDDHDDTCCSAVEEDIEAQHHHHVPTNAFLSIGLQTVIAIALHKFPEGFITYATNHVNPSLGLNVFMALFVHNIAEGFSMALPLYMALNSRFKAIAWATLLGGLSQPVGAGVAVLWFKVAKHSNITINGTAYGCLFAVTAGIMTSVALQLFSESLSLTHNRNMSIFFAFLGMTMLGVCDAIADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAH2</accession>
    <name>A0AAE0JAH2_9PEZI</name>
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    <organism evidence="3 4">
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            <taxon>Ascomycota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679329.1">
        <property type="nucleotide sequence ID" value="XM_062822575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAH2"/>
    <dbReference type="GeneID" id="87859729"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF1">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3340387.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40920" checksum="7D33BF55084C4A99" modified="2024-05-29" version="1">MVQSNHAAAEGLTHPNDNLSPHNDRNTENLKPVTSGQSLASRQVSQQTDTMKPARLSSDDVTLAVPAERVAEETDYTRPFDNGYHFPPKYSWQESTKQGLASFWKFFTTPMGAFWTFYGLNVVAWGGMLFLLICNAAPAMCHPTCNDINSPRRKWVEWDSQVLTGLFCVTAFGLAPWRFRDLWLLMKYRIKGQQEGLLRLAGIHRSWFRLPGTEELSPDIGPDNLPADVPKQCVPIPQEKMPNAPLTGVRAPATKVWKMDFMIWCMVLNTLAQVGLCGIMWGMNRYDRPSWSTGFLVAVGCIIAMVGGLVMFFEGRKVKRIEGVPCSERDLQKLAQDKELGILHYNNIGDKKPKKKKQSDPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAS2</accession>
    <name>A0AAE0JAS2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
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    </protein>
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        <name evidence="5" type="ORF">B0H65DRAFT_263030</name>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679479.1">
        <property type="nucleotide sequence ID" value="XM_062822641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAS2"/>
    <dbReference type="GeneID" id="87859795"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="352" mass="36288" checksum="BF76B85F210428F0" modified="2024-05-29" version="1">MGLGSLGAPTATRNSPFQRRAVSPVSPSPLRQAATSPLATPPVKQQQQSGLPGGASVSELTSRFANNIASSSGPPTTPGAGLGGAGPGLEATPTSQTQSQASWTPRASASAPTVVNPPPPNPMFLNGDAPPPRPPQHRISPLPSPSIPRTTTSASTMSMGTGGNAMSQLQPSQVRTLREGFQILDRDSDGVVVREDVIDMLNQLGLPNNASDVSQFFPPNGPQSMTMAVFLNSIATALSSLSPSGELLSAFSAFDDDDSGQIDVAELRDALLNTAPEPGERPLTSLEVDKVMAGFTGRRAFAQNNQRTTGLGGVGGGGANKRGEVFRYQEFVKMIQGTGNGGEQGSEDSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAV7</accession>
    <name>A0AAE0JAV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_559688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679433.1">
        <property type="nucleotide sequence ID" value="XM_062830131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAV7"/>
    <dbReference type="GeneID" id="87867285"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="385"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="551" mass="59682" checksum="4928B39E629B5F3C" modified="2024-05-29" version="1">MLGNIPAAVDSTAIKTSTPSTIHPSYPLTTNTQLPSPSLQPNYPGAHTSTLSPPPPAALSPASASAPGFGRSPRTAHDNPPVSLLQSPFRTRGAVAASNSPLNRQYTQFHSPHRQLPARLWNPTNSTPRLPPTPTAATRRRRQSSPPPPAIPLSLPSPHLDFDPSYPTATGAGDQPLLTVPENQQQARHSAISARASLQLERSTGSGQRSPLPRTLRHSLEGKRASITPSPVERVEETDAGSSRIRAIQEIPESNTSGRRTRGQSISSTKSRVPVGLSFDHGKKRLDKGKGKEGMAPTENEQDGGDRAGFSPDLERGPDVMDARQSIGSRISGIGSAISSDDSDILGDPDQQPDAGDEWGPQHACYPHLNPHVPLDSPEYINTRIIRVRRDWLLEGDLAPTFSNLYPEILEPAGLSEQEFRRVIQKLNSELVPIFSPYNWRNILDGVLGLATGWLWEDFGFTGVKGRLQKVEKWIEQWNKEMEKTVGSEDGTIPPKIVPLKRTGYMTLDIQIPDPEIAPAPPTPGASRGTDGAIQVEPTEPPQHPPAVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB61</accession>
    <name>A0AAE0JB61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_471433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679072.1">
        <property type="nucleotide sequence ID" value="XM_062827097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB61"/>
    <dbReference type="GeneID" id="87864251"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="115"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="388" mass="42278" checksum="B03C1E091B07A34C" modified="2024-05-29" version="1">MGFCDGKVVDIHTHMYPPEYVKILESRTSIPLVRSFPGSSDPRLILLDTEVPILEEAEAAKARGETPTNIPGRPLTKHYSSLDQKMHFMETHEIDISVVSLANPWLDFLSASEAGPIAESINADFSRMCEEKCGRLFFFAALPLTASQEVILSSIAHVSSLPYCRGVILGTSGLGKGLDDPDLLPIFQALADARLIIFLHPHYGLPNEVWGPRAQENYGHVLPLALGFPMETTIAVTRMYLAGVFDQVPQLNMLLAHSGGTLPFLAGRIESCILHDGHLHAAGTKPKKTIWEVLSSQVYLDAVVYSDVGLKAAVAASGPEGHERLMFGTDHPFFPPLGSDEEGEWESVTWNGAAVRKAFGEDAEGVKVQKVMGGNAVKVLNLRRDGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBA8</accession>
    <name>A0AAE0JBA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_275574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679842.1">
        <property type="nucleotide sequence ID" value="XM_062822803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBA8"/>
    <dbReference type="GeneID" id="87859957"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF5">
        <property type="entry name" value="RCC DOMAIN-CONTAINING PROTEIN ATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="124"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="179"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="271"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="369" mass="38753" checksum="2742E205F474780E" modified="2024-05-29" version="1">MLLLFALGSNGSGQLGIGHKEDVSVPKDAHFDADLPATASITKIAAGGNHTIILTTTGDIYWSGDPNTGACGKFTQTQISQPPRFYPGDLSSVSSPQDPFRVGLVAATWEASILTRLDAQGRNTRVYSCGTGLKGELGLGNFIFRTATPSLIPDFPPPDTEIVDLAACMGHVVAVLSNGDVWGWGNGRKGQIGAPEDIVHSPRKIEGLSFKVVKAVCGKEFTCLLGSQESGNIMVLGSNKWGIRAEAPDQVVEWREVGASWGNLFILKADGSLLSWGRNDHGQLAPANLPQTKHIAVGSEHALALSEEGDVTAWGWGEHGNCGPLSSSDVTKGQQNVIASSKFIPPGAKITTIGAGCATSWVAIQMPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBD5</accession>
    <name>A0AAE0JBD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_551009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679496.1">
        <property type="nucleotide sequence ID" value="XM_062829777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBD5"/>
    <dbReference type="GeneID" id="87866931"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="529" mass="58177" checksum="E7FABF2FA0C73B47" modified="2024-05-29" version="1">MSDTKDLSLGEKTHHDPSGFSSSDKGAEAGRISYDVGPHSPTAVTPLEPPEGTTESAIVRKIDRHIIPFIIFLYLLAFLDRVNIGNARSFGIESDLGLEKVEFNTALTIFFVPYILLEIPGNILMKKFSPRVWLSVCCVGFGLVSIFQGLVKNYGGLLATRFFLGVFECSMFPGCFFLLASWYKRADAQKRYSLFFSSTSLAGAFGGLLASAIGKMDHLQNYRGWRWIFIVEGCVTVLAGILFFFTFPAFPEQARFLKPAEREYVQAMLQADHGHSAAERKITLADVGKALTDHRIWLGGIMYLGLIVPAYSYAYFSPTIIGTYNYSAVQTQLHSVPPWAAAFGFAMLTAVASDYLRHRFMFAILGIAVAIVGFAVLMTVHDSAHVNAQYGALFLVAMGAYSAMPIIVCWFNMNLGGHHRKAIGTAWQIAFGNIGGIIATYSFVASDAKNHYRKGYAICVSFTCLSALACLCYAVSVTMENKRRAKMQGDGGLTEEEKADMGDLNPEFRRMIPKSPIKGETVAEFSEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBN8</accession>
    <name>A0AAE0JBN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_279231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679965.1">
        <property type="nucleotide sequence ID" value="XM_062822854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860008"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.790">
        <property type="entry name" value="RNA-dependent RNA polymerase, slab domain, helical subdomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="514"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3341023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1402" mass="157764" checksum="726C5548D6F6221B" modified="2024-05-29" version="1">MNPITPRKRNSPVEEIINRLNNDYNLGIQCVADASLTPHRRKELAEGDEDFGRHDKIYRALNFLYWRKDDSLNQAEANFFIEAKAASSNWVPKAHADPDTLPWSKEPPRAATAGQQWALQTVLLEVLNRFMPPPNNTPGRTFGRTLSGPSGLSRPTPTTTKRNDEPANVTFADPPKRSLARAATGPPTHGAAIPLKFPDPVNTGSKRPSLESENLNQSTKRAKGKLSDNVAAAAVPPVPIASALDKVPTRRHANTRDPTATGPRRADQGDSFTTSQSTSYGSSVFSTGRHNQNTNQSSIEAPPSQHREKRPVDATVFEAGNLVESPSKGRTTKAHIENQLLSSSSQGETSLSTYYESFPSSGGEGVIPEPSRSNGLARSEQSAQPQAQVHAPAVAARLKDIWPKFPKWLHEAPLAVAWEVTRLFMHCKVDLDDENLGLKYDPSWSTARDVTDIWKSLYQLDAFRGKSFPEKPANDVFVTAMTGNFESKGSAVVLSAVMDYNPDNSPTAPLYLVKLKPLMFEQGCRLTRRFGPDRFFEILIPSPTSTSPSVPPVVSKQPGAVEEVIQWLTKEPHSLVGRQWRAFFAKDAGYRKPLKEFRLRAEDPKPIIKERVHFFAETGITFRPDVFKKRSVVPAEEPVEQRTEFKVSQMLDWLLQLDNNTWQPHLKLFSRIQLGLSKTYAIMTLEPYQIRHHKSDLLSPSGTGEVMNDGVGRMSRSVAKKIRDVLGLGDVPSAVQGRFGSAKGMWVIDVDDTGDEDWIETYPSQRKWECDFIDKRQRTLEVRSVASELKSAGLNLQLLPVLEDRAKDKVKMRQAIGDRLVNDLQRQFSEQKHALNRPVEFRQWVYESYSSRATRVSHGRVPFLAGLPDSQEETLNFLMNSGFDPKKQKYLQDIAWDLQKRKCDTLKSKLNIRVGRSAYIYMIADFWGVLEENEVHVGFSSKFRDEEESFTLLSDCDVLVARSPAHFPSDIQRVRAVFRPELHSLKDVIVFSTKGDIPLAKKLSGGDYDGDMAWVCWDPEIVDGFVNAEMPPEPDLSRYLKKDKTTFKQLMASRGAGPEVKEQATYDMIQKSFHFALQPNFLGMCTNYKERLCYINNSVCNEPAIILSSLVGNLVDQSKQGIVFNEASWAQLRRELLGGALSLPDPMYKSDNWLGRGEPTHIIDYLKFSIARPAIDKELEAFHKAMKVAKDTEDGAHFWDPELAAYHTFFKDFGKKSRSCALLLTTLENRIGEVEKEYGRLVKNKDMKDSADSYPVRVNQVYEKWCAVTPEAMDKSEANYDSKVVRLLELSFLADREMNTWALLRASTAFKLYYRKSPKFVWQMAGRQLAYIKAQMTSRPGEGAPALMTAFMYAGLMPDKKFMKQYVARLEGDGSEYPDPEDYDLLGDEDLDGIGFTGNGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCM0</accession>
    <name>A0AAE0JCM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_549599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680176.1">
        <property type="nucleotide sequence ID" value="XM_062829670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCM0"/>
    <dbReference type="GeneID" id="87866824"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="355" mass="43269" checksum="97319FDEF20320CC" modified="2024-05-29" version="1">MPNVTSEVERRYSSSTDSSVAVTAGSSNSHSSSSPATTTSIPDQHQHVQESQNQAPAPAQIPHQDHQHHQYQHCHHQHPDQYHPDQHHPDQHYHHHHHPHSPQFLRLQSTWIYHLYAVEQARLSFLRAAQIHDTTWDQLNHIISRYHTMSEDDRQWLVAQFTWDERRLLREAEWKLWDLVNIDHPRLVEMVRAYAEGVWREREEEMGRQRQREEMRRWEEVVRREREEREERGRQLERVEVEERRVRLERVVQEMVRRREEARRLEEMGRRQREERERYLERERERRRREVGEFEARLRGAEVEESEERPRGMGRELKDASRRNEERFRRWMEESSRREGEGFRGGCEDCGRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCP2</accession>
    <name>A0AAE0JCP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_589446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680171.1">
        <property type="nucleotide sequence ID" value="XM_062831033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCP2"/>
    <dbReference type="GeneID" id="87868187"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="225" mass="25572" checksum="E6C1FF0AE6D9C81A" modified="2024-05-29" version="1">MSYQTPVGTSPLKATVAHDANQEPDHAPHRQATDQINPQDEQEKHTDNVALSDDKLSSPFDGTEYQEDSEQNTAKQNNKNPTNQTANTTVESHASVPCHGDLSASQARAIYTWLENQNNPVPDGTYHSVEEHSLVGFSEEELRHRAVDWMEFTHSDKPNGIVVVPPTWYSYSRFGPNRPRAWIKDFTTGRVRPRRMTNDLLVSLSLAERERKLNRERRDRGEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCP3</accession>
    <name>A0AAE0JCP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_443257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680218.1">
        <property type="nucleotide sequence ID" value="XM_062825628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCP3"/>
    <dbReference type="GeneID" id="87862782"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="345"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="515" mass="58542" checksum="CB010D3CDEA056D8" modified="2024-05-29" version="1">MEYSVDAFGEKEGASFDSCNQVPAYTEPAVDFTIPSAIYDMPVFGGTCSFYATNQLATKGQEVGIAIVHFDRSRMAETEKLCEYCTAIDFEQLRLPSSKDVEGLNKGQPIERIFPCTNYNVYNDDRPHWSLGTQSRIETSAATCSFCREVCHVLETSGVRVKAPSVFEKDPICDVYFTDAGCVEAPPGVTWKRYAPLETSLREFARKHEYLWRKLLPQKSPPSLRGPAFTYPRISLRWTVPEKHEMPSWKRYPEYEGVIELFECFQSIEVGTKKRQSLFSGRERPALIDLELPRRWLRDCLENDNDCCAPKLKGEGVKASIFRLIDTKTKAVVGFEEHRLGDTPYVTLSYVWGTTQQVMLKRENLLQLQSAGSLAHITPQTIIDAMIFTSDMGYRYLWVDLFCIIQDDDTDKMSQIQNMGDIYKNSVFTIVAAAGENSGSGLASIHTPRTVIQRKVQVKPAGPQEMPLWLISTVMPRTESLEYYTSSLPWHNCGWTLQERALSRRVFTFTGEQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCV6</accession>
    <name>A0AAE0JCV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_469387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680595.1">
        <property type="nucleotide sequence ID" value="XM_062827007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCV6"/>
    <dbReference type="GeneID" id="87864161"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="KAK3342802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 560.94</strain>
        </source>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830114.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87867268"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="303"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3342605.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48260" checksum="3AE3096BE74EEA22" modified="2024-05-29" version="1">MVKDESGHKHQSRDRCMRTTLTNKLRSWFLKLANFQFVIAGPRSWKPQPQSFTAMASNESFKVHKFSSKLPEAEAARQRENQRRHRARVKGKIAELESSLADTRERLDAALKHIRELEAENQRLRREASSSVYTPESRDESPAEQLLYMSQSGRNGYHQYSQQHQFEPHQPPRQQQQQHRLPPVNGLDILASISSSESAVPPRHRTYHPHELDCARNLASLPSYEPTPIASPRDMSPIAALLSMPTATGFHSPSATTISASPSTESPRRASVFDFSSSHYNPSSASNSQSSDKIGELIDCLDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDEDDLALPAPRPGESTMPCREAFSIVRKMQTTRPDYYYCDADGREVENVAREQWRPGFRSAIEPGSGCRVQTHLVYDFVDHITGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062822086.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87859240"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="439" mass="47638" checksum="AD1B1AC41E0C6418" modified="2024-05-29" version="1">MDPEQYGGRTDDDLFADDFEPVAPEEQVATISTETGAPVQDTNITSPASTAVELSQPSEPAPVQKSAPAPQAPRGLANSRHAPANRPEKQPRNNNRHPKANNSASNNSATQSQQQQSTSNAPPSAPKELREKEARDKEAGRNTASVSSAARIGSGANPRTKLTEDELAAKMEKMRIIAAEKTKRFEQAQRDETEHAAAYAKGMEEDRKRRAEQAAKRKAAEEDRKKMEDEREKNRERKMRAMGAKEGGSWDEGKEERMREEDRRGYRGVKGVANTQSWAQDPADGNERGDSYRGGRRGGRGGFGGGRGRGGGDGYGGRTLFEPDPENESGQRFYQRDNHRNRGRDWKADGPAAPRAERSGPGSGAPKADKPKLTPDEFPALPGSKSTAPQVSTNAPLSFASLPLSPAVGRWDDEVEESISKKAAQAKEAADAQAKSKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JD26_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062822171.1"/>
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    <dbReference type="AlphaFoldDB" id="A0AAE0JD26"/>
    <dbReference type="GeneID" id="87859325"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042136461" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="4">
        <location>
            <begin position="46"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3342795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="552" mass="58447" checksum="2A06CFD7089759D4" modified="2024-05-29" version="1">MFSTTWKSTALMLPSLLFWLSGDVVQARRVAASTCPAPVPASYPAPVVRDGYEARLVATGLKKPRGVIVDSKGRLLVVEAGKGITHMTIKDDGWPCLSVEKTTTLVSMTDLNHGIELSVDGKTLYASTSNSVYSWAYDADAVRVSDEKSPKTLISNMTNVGGGHSTRTLLISRKQPGILLVSRGSGSNIDNGATDHSSGISQIRAFDISDPNLGTPGGGKVYDYPSEGWTIGWGLRNSVGVAEEPNTGGIYSVENSADGIKRFGVDIHEDSPGEEMNYHGILRFPSSSPSSSNVSSSPDQGQQQGGNHGYPYCLALCNSSLPFPSLNTLKTGSQFTHDSTPYSIPYLSSSDSSDTSSPQAKPINITTSDTSCSSANFIPPRLTFPAHTAPLDIKFSHGNDNQSLAYISFHGSWDRSTPAGYKLCAVLFDTSKGEPVEASDSTNSLVDVMWNRDVSKCPEECFRPVGLAVDGEERIWMTDDDKGDVWVLKQVGEVKGDGDGNGNDFGSGSANGDSDSAAAPMRAKRSGSGAEWLGVGTSVVGAVTVSVLFGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE31</accession>
    <name>A0AAE0JE31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_510111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680968.1">
        <property type="nucleotide sequence ID" value="XM_062828368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE31"/>
    <dbReference type="GeneID" id="87865522"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3343175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126676" checksum="34D9D2760151DC56" modified="2024-05-29" version="1">MADPLSIAGLATGVVSLGIQLYHDLQTFLDIVKHRDEDIAKLTRQAATMAQVLDAIDRSLQNSNQANNGVVDSATIIPLLDASRQELFLLQQEVASLTKTSKGQKASGVVEFARITTQKLKYPRQRANIQKLEEGLDQANTTLQLALNAFGLYESLKHLLIIALLSTFRSELSSIKSNTEVVAYGLSNVQKTLPDVEARVSELSEKLVATNQTATQSIQNVEGILNLVISSHQADLKQLGQAQSNEFSQMKQLIQDLSLKMDANASIGPKDIEVHRNLACLMSKPSALKTLCDEHYGEPTSWSPPDTRIWPACTCRCSQIITQRSLEWGPFRLSTKSKAEFVHHESCQWARFDTPKRSKAISLAYRGFTHLLRCAVVINFRLNHGAGGFSLGPGIVYYPVVDENVYAPFRLVEYVCEAIITLDPTLKHKVLEAFSRHISRACFNGVIIPRAVNIGGETLLHYISHLIQVTNPDLSQEDYTYGVLKHWWTPSMIALVHKILANLIMCNVPSTVCDNDGRLAHLTIANYIPHTNKNMLVPMTTLLELFTSRDMDFDPPQARDQPDPFLPGFAYLKPLPEPSVFSKAFCCNQLGTAILQRDISSVRSLLSRAPSLVFEWDLNGMTPLHYAVLWKDGLSIILEQVPVENFAEDLAWDIFRYALSAYRTSCPDLCLEKCHCSECIMLFLDHSWYFAPCSSRGRDHGTLRLLLGQSPLSAQEKFLLYLKQSRQEIVGLALQKLFGDDMGRQLDTVHWIIDHLQKTATTSPPTRRARIQAAVDSFTIYCEIDYAQTAEFASQLGFPFPPLVHNALVEDYALVEDYALWLLDHGADPLQPLHDIENCNALTLAAHKAIYCITSPRWDQWGDIGVAGLELNVLSQAAHEVARHEPTTDSCLCACSANGCTPFLILLRILAPRSFNSPRYALSQPKDYACEFTHIRTMLYGNDGFYEVQFCEALRLFTFMALGIRHTCCKKHGYHNEGNVDEIHEEDSELVDILENLMEQWQDVSFESANDFWCFLHHDWVIRLNEVFEDMRQIDQTEENRDRLQSLGVQLHAPIVDANVPEPPVRRRRFIWWEESFWLDLLDTVAEGGDTSYFDRVLEDAWDMRRGIGRWDEEEGQWEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF87</accession>
    <name>A0AAE0JF87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_194206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681683.1">
        <property type="nucleotide sequence ID" value="XM_062821688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF87"/>
    <dbReference type="GeneID" id="87858842"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="12">
        <location>
            <begin position="183"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3345070.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="259" mass="30327" checksum="F8FC91733721FEE3" modified="2024-05-29" version="1">MSRKSVMSSTFEPSLSTSRQPLGPSLADTLPSINFGFDELRDRMAKFTAKFDDFIEQGRRRVLEERNQFRMNVAELQEDQRMKKKDIEILQLKTNTYQQTMAKEAAETREMQQAIASLTEQRDKQAAMRDALKEQIAATQREIDARLAAQRAHAAQLEAQARYNVPELDFWVTNLCMRIEGAGAEDRLKFVYTHIDERNWEREAWFELSMSGRDYDVRHCRPKLEREKVEKVLDRVNETRELVVLLKGMRELFVEAMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JFN9_9PEZI</name>
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    </protein>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821894.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87859048"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="4 5">
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="87859082"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
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    </dbReference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    <evidence type="ECO:0000256" key="3">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682194.1">
        <property type="nucleotide sequence ID" value="XM_062829646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFZ4"/>
    <dbReference type="GeneID" id="87866800"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="361"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3345581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="708" mass="76398" checksum="1D6824B9828D2FD6" modified="2024-05-29" version="1">MEGIKQTFQRCKAQNRPALVTYVTAGFPTPEQTPDILLAMEKGGADVIELGVPFTDPIADGPTIQTANTIALQHGVTVHSTLQMVRDARQRGLKAPVLLMGYYNPMLSYGEERLLNDCKEAGVNGFIIVDLPPEEAVSFRQLCSRGGLSYVPLIAPATSDARMRVLCQLADSFIYVVSRQGVTGASGTLNANLPELLARVKKYSGNKPAAVGFGVSTHEHFTSVGAIADGVVVGSQIITTLQKAAKGEEPQAVQEYCSYLCGRTFDESAHELNMGEALEAAKEPSGTATVDSVITEADIDSQLAALHGTIPKRFGEFGGQYVPEALMDCLTELEDGFNKIKDDPAFWEEYRSYYPWMGRPGQLHKAERLTEYAGGANIWLKREDLNHTGSHKINNALGQLLLARRLGKKKIIAETGAGQHGVATATVCAKFGMECTVFMGAEDVRRQALNVFRMKLLGAKVVAVEAGTRTLRDAVNEALRHWVVHLADTHYIIGSAIGPHPFPTIVRTFQSVIGNETKQQMLEKRGKLPDAVVACVGGGSNAVGMFYPFSNDPSVKLLGVEAGGDGVDTDRHSATLTGGSKGVLHGVRTYILQNQYGQIQDTHSVSAGLDYPGVGPELSNWKDTERAKFVAATDAQAFEGFRLMSQLEGIIPALESSHGIWGALELAKTMKPDEDVVICLSGRGDKDVQSVADELPIIGPKIGWDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG30</accession>
    <name>A0AAE0JG30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_442987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682269.1">
        <property type="nucleotide sequence ID" value="XM_062825606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG30"/>
    <dbReference type="GeneID" id="87862760"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="201" mass="21366" checksum="E5FBA8AC0FAD5804" modified="2024-05-29" version="1">MNHTSQKHQNALDGIVPNKVGQEALQHQGVPVLSLDLVVTPASGDRCLYDGQQHRAESGHQPTNIQMALRSSVSAARLYLSRSSRCSSGLFSVRSQYCFLFHALFLAAMACQRSGYISFIMFLAGPSDDCVAGRYDLRAWGGYGVQGRKCGPLLDQCLPGSTSGPSSTTSSHEATSTVEHQGDPVLSLSLAAGPDSGGYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG38</accession>
    <name>A0AAE0JG38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_574965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682335.1">
        <property type="nucleotide sequence ID" value="XM_062830602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG38"/>
    <dbReference type="GeneID" id="87867756"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="316" mass="35280" checksum="3E91099A06B140B8" modified="2024-05-29" version="1">MGGEMCSMLREKTPNLLNYPTEASLEPSFVPATHFQRPYLGSHAKFEVSTSKLVTPQMMNSRPPPDLRSLDMTVLRSNQGSLIRPSQASLDTGSSASNSLYNRPVPFGYYYRCSYFPAIYSCACNGSSQTDGKEIQGEIQSAPGDGCDFGEILNRAMNRASGRLIALLQEELERLSSENELIGDIEETDKALSNLNLDNRKSGRQQLHPALSSLYLVTPLLLGFLFGCIVWPNDEELTTLKEQYEALRDDYDFVTSMFKRGLQASQDQVAQFEQQVQQASARFASKVWAAIAKYGKQDAERQKAIDHLQESPYAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGA9</accession>
    <name>A0AAE0JGA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_460085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682389.1">
        <property type="nucleotide sequence ID" value="XM_062826510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGA9"/>
    <dbReference type="GeneID" id="87863664"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="55"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="302" mass="33887" checksum="0D038945E597CCE2" modified="2024-05-29" version="1">MTTPEQDGAARLAARKPIPKPVPAYLPTAGSPLSVDKNLYSTIQQAPRVLTEEFTIPIRSGRAWTASAGSIIRISTPEGPQVGDLNIWNLHNPRERFWASRTKQLHASHVSTYDRLWSNLPFMRPMLTIIADTLSWYEQDEHGGRVHDLLGTRCDPYINNVLSGGEFDFHCHSNLTRAVMEYGLNEGDVHDVINLFQVTGLDEKGRYFMSPCPASKGDFVEFLAEQDVLMALSTCPGGDLSLWGFGSDNEKEMIKCCRPLKVEVFRLEDEQLLQRSGWKPAEKANYRGRHGLVVAERSTSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGB0</accession>
    <name>A0AAE0JGB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_197674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681787.1">
        <property type="nucleotide sequence ID" value="XM_062821740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGB0"/>
    <dbReference type="GeneID" id="87858894"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="232" mass="25781" checksum="8129658F5DC3AFBF" modified="2024-05-29" version="1">MCVTIAGLYLPHGQRLASTPCRRKSGYYRRSQLGVSLLASSFPFLRRFCEAGLGKSMEAKEVHTTWLALFQVECPPIAIGSFLLLHHYRKRDAVRSSEAADPSHWYPIVVRISEAARREYRIPILRCLALNKISGLFPGRGHDLQSDSGSLDQSYGECLSNGRFHLPPLPPPIADVASLPAMRYVDIATMAPRCRAARCPVLMLRRPTQLLFPRLGSRSNTLPPGSSIVTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGC7</accession>
    <name>A0AAE0JGC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_569977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682407.1">
        <property type="nucleotide sequence ID" value="XM_062830431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGC7"/>
    <dbReference type="GeneID" id="87867585"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="365" mass="38219" checksum="C51E1B79C53E18A0" modified="2024-05-29" version="1">MRFPSSYYGGISPSQLFGRGDVCTEAFPNGGAYSKTCTPGNTTCCYRKGQNFPRCVDGGGKGWCCEGTGSSNCFVDQASACDEPNAVVCTNLARGAKKACCPSKSKCDDDFKASELDVRCRMEFDNLVKLAAGKVGLELPSTESVTVSATGGSMTANDQTSRSPMASSSGGETGMTSGASSSTPTPSSASLTSGLPTGVVALPSASASTSASASSLPSSTPSDTNATGVTSFWRSKSAIASVTLCILLFSAFIALLVFGLRRQRKKAAAIRAMTQLPRGAYIPERPGYLPLETEQNAAEMSSTPAQDRQRQREVEQRDGEMRPPSYYAACPKGQPPGRDGEQEDEDELVELDDTQVKSVLNGEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821034.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="123" mass="13695" checksum="6321E156F6CAF4C2" modified="2024-05-29" version="1">MTVTAHLHHPDFLPDCSLCHTGDLEAATKIVNRETPLVSTASPARGTKRPSERCMGRALVRTSQKGHPIILTSLKSKKSNYALGKREKKEEKKGCEELTRYNEEIEVQRYSQSDCPRAVSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JHK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_441236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682711.1">
        <property type="nucleotide sequence ID" value="XM_062825513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHK0"/>
    <dbReference type="GeneID" id="87862667"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="147" mass="15385" checksum="6ABAA63C3EFB2D41" modified="2024-05-29" version="1">MALVEWLKIEFPNLSTTQINSILAAHPNSSPTNRAGPFFEMNGLSGANALNMSGGANGQQQRGYNIYAEATFVCPAYSLAGSDQGSRARQADERGSQMQAGYGRKMKEAAGFGSKSCGWFVALNATPVSQPAALSSQSTRAAPHPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHZ9</accession>
    <name>A0AAE0JHZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_462851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683325.1">
        <property type="nucleotide sequence ID" value="XM_062826661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHZ9"/>
    <dbReference type="GeneID" id="87863815"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="242" mass="27522" checksum="EF565A216D9A8142" modified="2024-05-29" version="1">MVSRWLTHHAYSLAWDKYQCHPPPLLSWHSTIRITQTWHIAKVTGRRRSIRCSSSVGSSSFTIAVQASHYDRDSKQEEKSTSGLTKGLHRTTIECDRHGLSVSSPRISIEFLSTGRQHHQLRSSASRFVAKWPGVCKRLDGAKRIGMLYGQVQLQGRVLFQNSNAGANAYDMLEHARFSAVWDISNKHSLPVDRRKVSWNSSQSVERGRSDIYPCTYQQGCKHNVLFQRGRRGQNDVHNAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI67</accession>
    <name>A0AAE0JI67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_166677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683203.1">
        <property type="nucleotide sequence ID" value="XM_062821307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI67"/>
    <dbReference type="GeneID" id="87858461"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="120"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="246"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3348121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="386" mass="40054" checksum="66EEFCF6054422B3" modified="2024-05-29" version="1">MSADFWAGYISGAIGIVIGNPLDILKVRLQAGSSPSSSPSVSSSSLPTPTPNSTPSPTPTASTGTAATSWIRPFLRGTAAPVLGYGALNALLFVSYNRTESAINQFVFGIDPSLPSQTGVNLWSTWIAGAVGGLATWVVSTPTELVKCRVQLAGQGQGSGTEGRGGIGREKGSWQVAKHVLRTEGIKGLYFGGAVTALRDSIGYGFYFWSYELSSRWMVAASASSSSSGESSSSSSSSQAGGIFTSEASRVLLCGGLAGIITWASIFPLDVIKTRVQTQGILGVGASSASSEQTALLDQTTAAQRKQRPLGAWEVAKLTYREGRVKPFFRGLTVCSVRAFIVNAAQWAMYEWIMTELGQGRRAKASAAGVEAGALGGGELVAMGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ02</accession>
    <name>A0AAE0JJ02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_423001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683593.1">
        <property type="nucleotide sequence ID" value="XM_062824430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ02"/>
    <dbReference type="GeneID" id="87861584"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="181"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="675" mass="75645" checksum="42B6CCA3B8085220" modified="2024-05-29" version="1">MARASKDISTTLATLPNAAVSISLPVLSRAGVTPEISPLVRRFSNKAVVEQPDSIPIQAMGAVVRRETDEQRNNQQRLVEWGRWLDFVMGSTDDDDAFPTLEVQSRDLIDTWRRLSKSLPGMMDLSPQGTWIPTVSTLKQAVVQAENTMKAKKLNGFGLLKDRFHSLVQTLDDHKYMFAIIPQGDRYVSLFTGVVSFIAKASINHIKIGEAFSIALSDVSSDLSYVRKSAMVSDSPKMRKLVVDVYVEVFKLLCQALGWFTSRSRRTIAAFDRNYYARHVQPFVDRIQKAIQRIRDEAHLVTHEVVQEIRDMGHVLLQRTAGRESRMDSEEMSHEKLSRMGETLGFSSVRTLSSVEQQAAHEAEIAHLANKNIDAMQVEGECRGRRRPPRARHKSDLSDLEQHVPAFLSRYLEDGRSDFSRNPSDAFSTLLPSEVITELQKWITAPKSNTVWVAGHPVSPFGSGLSVAALRVCEIAKEIRIPCISFICKQRYSFASSFSAIRKNGSTGKLDPKEAGLIALFYSVTAQLIYLLPDQPFPSSTVLEKDNFERLDGTMASASTAMEIIRELAIHAPPSLIWVLDNVQNAESTMTYAHLKTFVEFLREQERKTNSAHEEGKKPFSKVCFTTDGNCVLLSRLSHRDKGIRQIDASRMAQRRPGRVLPGGADVGQLGWSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJF7</accession>
    <name>A0AAE0JJF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_419140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684105.1">
        <property type="nucleotide sequence ID" value="XM_062824189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJF7"/>
    <dbReference type="GeneID" id="87861343"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="370"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="957"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3350810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="108881" checksum="F80D2CA7B732A0A4" modified="2024-05-29" version="1">MDDLSGLDWSASSNSNSSKPNPPKTTTTPAFTSFPAIRPTPSPFASGLSTPVLSTQGAGAIAPKSNNNPFSKPAQDSFSNLGSLVNFGSSSAQSTAKLSLKEQQERLEAERRRKEEERRQQLQAQYGGLDALGQLGSGGSNSRTTSPAFGLGGPTSIPSPAISRVASPLNPTTLNQLNMTAKKPSDSDDDLFAAFKAETKVDNASHYPPPTVSSPPPVTGLTASAQPRLDLSDPSAWGAAKPSTPVPVPVPAPAPAPAPVSTTNTAFAGLDDDDPFGLGEFSAAKTSAPPPAQSAPAFDDEDDLLGDLAKPVDQVKKQQQQLQQQQLQQQQQRQPQPQAARPSFSQTREPGKPIEDDEDSSSSDDEPERPSDDPFDRAVAQLVDYGFTPENARRGLTESGAGLNVQAAVNWLLDDAHRQAKEEARAKNGGGGQQHTGRSEERGASQSRAGRGGQGGPSWMREEQEQQAERSRSRDNRSPASLAEVDFAKTAAAVGTSLFKTANSLWKTGQKKVQEAVKEFQHEGGDPNQPKWMREAAEYEQGGRRAQAPNVTDEAMMLEGGGRPARRPESTREQRPAEPRTASNGPQRHASPVPRWQQQAPPPASLDPRSRLSKQAIEEQSSQAYVSPARRKKATPQPQPEAPPPAQFEDEDLLFGSSGPSKSQTTTTTTLPSRPVAKSTAPPPPAPRRSPAPIQPKPAAPPRQIPPISAIALQSSTKHRLEGTAHFKRGDYAAAHTSYGASLSAIPSMHPLAILLLCNRALTALKVGEPRQAVQDADAAMALIGPSKGEGESVEVQTSEHGPQEKRDMRDLYGKALTRKAEALEQMEKWADAEKVWQSAVEAGLGGQTAAAGRQRCQKALAPKPAAAVSAPAVKKPSSAPARPRPTPASAAASTSQKSSEAVQRLRLANQAAEKEGSEKFALADKVDARIASWRDGKKDNLRALLASLDNVLWEGSGWKKVGLHELVVANKVKIVYMKAIAKCHPDKIPTDASTEVRMIAGTVFATLNEAWDKFKKENNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJN2</accession>
    <name>A0AAE0JJN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_90676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683821.1">
        <property type="nucleotide sequence ID" value="XM_062831551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJN2"/>
    <dbReference type="GeneID" id="87868705"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3350526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="433" mass="47246" checksum="CD12B1097804D4BD" modified="2024-05-29" version="1">MASVTDLKLAQPLTLPNGLILPNRLIKAAMAEQLGFGNHLPNPELSAVYSVWARGDWGMILTGNVQVDHAHKGDAHDISPGHPGTTPEQTLTAFKAWADAALLKGQSRTPVVVQINHPGRQSPMGAGTRGLWEKAVAPSAVPLVLGEGLVPRLASKLLFGTPRELTVAEIKDIVQKFGYTARITAEAGFQGVEIHAAHGYLLAQFLSKKTNKRGDVYGGSAENRARIVGEIIEECRRQVAEAVGEEEAKRFVVGIKLNSADWQTGRNGKEEETDTTEEVLRQIELFEQWGVDFVEVSGGSYEDPQMANGPKVEKSERTKAREAFFLEFAKIIRTKFPKLPLMVTGGFRTRQGMEAALATDDCDMIGIGRPAVINPSLPANLILNPEIPDADARLFDKKVEPHWIFEKLGMKSVVGAGAEIGWYVSEIKKLAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJS6</accession>
    <name>A0AAE0JJS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_517930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683851.1">
        <property type="nucleotide sequence ID" value="XM_062828686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJS6"/>
    <dbReference type="GeneID" id="87865840"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3350556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="453" mass="51209" checksum="8E526344C4AED748" modified="2024-05-29" version="1">MLRSLIRLHFRRNASSLFQFSGFPLSSSTVALTTTKSPISVNKSRNMSSSSVPPQPPPAPATTRRPTGAVPFLEYPSPNATSTSSNSSTTKPKRYLLFFISGNPGLIDYYAPFFTHLRSLLNELESTSASSPGQQPITFHIYGQNLIGFSDSDHQPFSPGSPETEPFLLEEQIAHLYDSLVSLNEEKGPFDEIILAGHSVGSFLSLEILHRSLQSSSSSLPITTALLLFPTIHQMHLSPSGLHLSRIRSIPFLNNHAHVLAKSFVDLVPGFALRWITRRVLGMSEHGSEVTTRFLQSRDGIWQAIHLGKDEMGEIRDGEGRWGWWSSPTAPTSHEQRDEHEEQEVVAKEMEGIESDWERFDAQIRQEHEQRKGEEEKRKKPKFFLYFGQNDHWVADQYRDEFIERRKREGHTGKEGGTKIVIDEDKIPHAFCINHSEQVAEKVKLWVEEVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJT7</accession>
    <name>A0AAE0JJT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_96413</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683993.1">
        <property type="nucleotide sequence ID" value="XM_062831619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87868773"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="574"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="1041"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="747"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="912"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1169"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="912"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="948"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1183"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1221"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3350698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1283" mass="140544" checksum="E29B54D72D99CB8B" modified="2024-05-29" version="1">MRIAIREQLAALVIFAVLLSLAIVSIPVWIFVNNFVIGVKTDGLALSASLKASRISSEIDLIQTACLTISTRLLLQQAFENFYTNEYYRNQTSDVWKQALEDLASALSTSNVSGLLQARLYSRNSTGDSSGLLNITGPAALDEPVYLPYKSPTGADIKLGDPDYGFPSMLYPNVTYENKNLPSPYRNNTSQFSANIFPGVSLGNGSEGNGILLGPLVVNESYALVSITVPVRENQSSKFILGYMTVVASARQLVEVQKSSEGLGETGIALFIGPVNPWNHFNSNMPASNQTWNPPRDKFARTNQVHFLFPPAPQPGQEDRHSNHSFESGAYDAPFDLETYEAVLDLFVERSNQTNNAMSKISTHNEQGKRVAIGAARPQTSLVSWAVLVEQDYREATEPIRTLRNILLGCVFGTAGLVLLLTIPCAHLSVMPIRRLKEATENSIAPPGYEELFDSDFDEENPSSGGTTSGRSEKSWFKTLKRRMRKSKRARMRAAAAQDAHRHAFKIPAKVEDRKHFITDELTELTQTFNEMTDELLKQYTSLDEKVAERTRELEISKKAAEAANESKTLFIANISHELKTPLNGIMGMCTVLMEEDDVLRIKQSLKTIYKSGDLLLHLLEDLLSFSKNQIGQQVSLEEREFRLGEIRSQMLAIFDKQVRENKITFTVSFVGTDLLDGSSPERRTSIEKRLPALGPPGVGRLKDMCLWGDQHRILQVIINLVSNSLKFTPAGGRVELRIRCVGEIEQPQDESRTSSFSKNSHRPGRSRHRVGSGSRDSQSSRGAPHSPNQNQSSGTALSINPMDPKSTPHVQIRERSPTPPPPNAKSFMFEFEVEDTGPGIAEHMQQKIFEPFVQGDLGLSKKFGGTGLGLSICSQLATIMGGTIGLKSTVGVGTTFTMRIPLKYVRDRASSTASSSLASRPHSVSSLDGETIRNPLPKQSTVDIHHGHSHSHSHSHSHSHGHNQHPTAPPAATSVLDTQPRLVGLSQPFFATTPKCPPPTTTTTASGDVDDKMAALDRAMAAKQLQQSRSSSSSGPGKLRVLVADDNSTNVEVVSRLLKLEDVYDVTIAKDGQEAYDLVKANMEHNLQFDVIFMDIQMPNLDGLQSTRLIRKMGYSAPIVALTAFSEESNVKECMESGMDEFLSKPIRRPALKQVLKKFATIYEEQGETETVPSVTTGSLKGDAEKEKKGEGKGDKKDKKEGREWKGLKDGKGDGTLVNGTTTPKTASSTTVAATANGSTTTSGTTMMNGAPTRPKPMDMYSDEPSPKSTPKSNGDYLKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJZ1</accession>
    <name>A0AAE0JJZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_107013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684342.1">
        <property type="nucleotide sequence ID" value="XM_062820503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJZ1"/>
    <dbReference type="GeneID" id="87857657"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="306" mass="33833" checksum="8C39814E3BF7BB39" modified="2024-05-29" version="1">MSQAFRFPAGPARIRTLYIRVKPAPTSLSERRAVLRALSQHGNIEMFKQLYDSSSFISIASSQNAAASIVRRSPLQFDVLARNLFDPRVPDSIRLPPPIDTSSAVSLPSAVTTGTITNSNSKSGQTDLNPQQLPLSPSSSKLPTLPERDPTAFVTKTFILEAFNAPEYPHKEHIRMSALYGPWPRDDPDPPSHDTPTSSKRLTLTSAALRASVPQDMAYTGLHDWESAGQDAMDVEEATAIEEGISADSATMVRTWRAFWRERVDKGDSLQYQLGTTGDMGSAYSHIMKRKMKQENKKRIQNMLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKQ6</accession>
    <name>A0AAE0JKQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_110713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684506.1">
        <property type="nucleotide sequence ID" value="XM_062820573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857727"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1440" mass="156856" checksum="620CBC00E1CB09E6" modified="2024-05-29" version="1">MNSGPVSSSPASGSASTSTSRPTIGVPERKYIPYRQGAEEQLKLTVGNRAGRALKAPTAPVMSSSVALVETLLAPEPGPERASSPRYCSALRERCVSLSDGTVTATPTSSVTWQDQDRRKKRTGVGSLAISAPYKKGHRRSPATAAADWGGGKKKWKRSRNPRWKENLDHLLEVEVEIEVEANTADAAGTCTAGTNVTTPLLVAQVPQSAPAAAVVPGAVPSPTTGSGTSQSWLTFPKTGKEGNKPSLPSKPPLHHLLPCNSNARPGQDNNDVNRNKWEGVPGSDGDGRGLGSKPASSCWSSSSTSPSLLPHLPPLSSPALRPRLQLQACISSRAGENVDDPQHSKGNEDGSSRSRSISSSNSLSRHQQSRNKGGNQYKDKLEKDAAVFLLEKKGPYLPVPISPSFSSSEPAHPSPTTTTQQQHPTRKQTQTQKQTHSYLGPDLQLNLHTNHHPNFPAPVRFLVSATATDCAEVDVAKETRNWLEQVFKDTVGDTTARERELTHGQDHHHSFLLPLPLVSGWDHNPFDPATGHGRQPVNGAAEERPRSPRTAQIKGQIKGQEGLAPDKGSNLNGTKGTTNNTTGADGLASQTSQTSVPRLDTGADSQTLAERCKLETDMIMDHQHLHRHQSSAVPPSPAPSHSSFSLRGKNRVFGKLPFLSRGRKPEGPTRIEIASPTSPSQPKPPTSPTSPVSPASSMGAPIDKTRSRSRDARTYAGSGGRGIVPVQDEVPKGAINGADRRVTVRCKGVTVDLKVEVDTTTVDILLAYADKTGLPVNVNTSMVIEAYTPLGLERRLRRYERIRDVLNSWDQDMQNVLIIQTENDRSDENLDLASVPREHKIPTGFVLPLQHSHRPGKWTKRYITLLENGQLVSSKKPDAKLSDKDVLSICHLSDFDIYTPTEAQKRKELRPPKKHCYAIKSQQKTTIFMSTDNFVHYFSTEDAAVAHQFSARVQAWRSWYLVNKVLQLHKKRQERDAEKPPQLSSSPHKPRMAVKDVNVDDGHKIRVSVDESPYPIGTFKPLIDLQRFDKPIDEFGKDWEADRSRQQAPPLPSLDKLQKVRRATQEEQEAPFGTSGLLGNIYEERKQAQKEEERKKPEVVTDNPFTDRPSLLNGGLVTSPTEETGQHDGRSEPKAWLPSAVEHTATQRSTRAPSVRRSAPSNQPPPSQYAPSHYAPSQYAPSQYDRGRETHRRQQPNQQRTPSGPLVDLTPKFVEPPQWSREGKGRGVRAPEGMPLVDMATGFQLAPGAKPLDLPPRTLVRREPSMRTPGSRPGTSGGQAPPGSSAGSVRAVSRAPSVRSRMTSRDGTSGGMRSVSGSAYPPPVPPIPGSVLGNGPNYPPPSSRGRDTEGYRPRSSSGGPQPQSKQGSPPSSGYEHDRQRTFSLRNQPHPLLSFDEALDEPRGLLGKADRSNTDSMQRARSVRVGNSSGRARNGSIYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL31</accession>
    <name>A0AAE0JL31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor SPF27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_506646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684496.1">
        <property type="nucleotide sequence ID" value="XM_062828077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL31"/>
    <dbReference type="GeneID" id="87865231"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3351201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="224" mass="24698" checksum="0D570D75F8F4C9CF" modified="2024-05-29" version="1">MPLITTIHESLPYIDPEPTPSDRSAAEALIATERSLVPDDPYHALLPPPYSPSSHLTPLLQSEFDRIASSLATNPDAPPKLNALDLSRYSSLPEIPTPSDLTAMDSSEASTLLSSLLEKAYTDHAYVAQRRAHLALLDAYGKNAWLIGNWQLEGELKAIEKELAEAKREIDLVTLQRKQAQDEAGPEILGLEDTWKKGVGRVLETEAAVEGLRRQVLEVRRGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL87</accession>
    <name>A0AAE0JL87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_106905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684337.1">
        <property type="nucleotide sequence ID" value="XM_062820499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL87"/>
    <dbReference type="GeneID" id="87857653"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3351042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="369" mass="39656" checksum="8D650B0B376D9ED8" modified="2024-05-29" version="1">MAVDQESFVHLSRPLAPNVLGFGVSNAPLTVNIQPQAVFSIIDHAVRRDDRDTQSTRVIGALVGVRSEDGSEVEVRSTFAIPHTENEDQVEVDVEYQKNMLALTLKASPRETLLGWYTTSHELNSFSALIQNFFASPETGTFPHPAVHLTIGTEAGAPIETKTYISAPVAVSPERAAESCLFIEVPHKLLFTDAERGALGSVAAAADAESRSAPVVSDIENLAQALETVSDLLERVSGFVGEVLDEERDGNHALGQYLMNALSLAPKVSNLAIENDFNNHIQDVLMVSYLANTIRTQIELSQRLATAKLDEGKEGGEKKDGEGAEGDKKSDGQRGQRGQGGKRGGRGGGAGGRGGREPREPREPREPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL94</accession>
    <name>A0AAE0JL94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spray</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_107236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684352.1">
        <property type="nucleotide sequence ID" value="XM_062820511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL94"/>
    <dbReference type="GeneID" id="87857665"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="99753" checksum="7E2C8473B7B9D85C" modified="2024-05-29" version="1">MDYQYAPHPQARPPLHSAHSAGSFSRISTVSDLTDFDNVQPRPSLVSLQSEYDNSGSNHQSYDVGGEGGHVYTGAQTGWSALASLPGLGGGGARNSNYEPVHFSEQLSLNQHQPPPFQRNRHSQGRSFAARAAHLNRRHDTIPEEDGIDLGLIQSAAPLGGSQPRAPAPYLRMEPVFDVSAALGPSTDADDKFIRSLQEQEAQGKLTGGLGAGIRTDAVVTESALLATSPISDRGSSMRRSFTRAAARLSRHDTVKQLAQQEANKRGEVIELVMDDDVISNSGKFDLSVVAGPDPGSKSPYGQMRQTTFPTMKRTEKQVFYPTPDWKPFSMRWPYLVSLIIVSIVAAGGVEVLYQRSAKQPLVVFKSPTDITPTAYFCIKFLPTLIAVTYGVLWQITNFEVMRLEAFYQLSKEDGSLAAESINVDYFTFFNLFRPIRALHYKHYAVAVSTIASLLANALVPTLCSACIILSPDRDTRLLNPNDEKRISIHAVWSRILTLTLVIIAVFGCILFYQLQSRRSGLLADVKGIAGLASMATVSHILMDFKDMDVATHKDIHNKLKNHRYVLRNSALAPADEVYNKPLSKKEQDRERYTGSHLDENPHPLSLRAAGAIPFIIFITLFSVLIPCVLFTPANVLTDRAPWVITALAVCLKLSWGAMETDVRMMEPYYILSTKRHAPPKTLTLDYRSMPFGGWVALKGAMNGHWLVSFVGFGSVMAEFLTVLVTSLASVEGRVFVDATKEALLLDGKRSEFQFQARDDDEIDDTNSINAGQETPLSFWISLCLADFVLLYMGVIATIVFIRRRRVFLPRQPNTIASVLAYIHQSKMLYDFVGTNKLSNAEMVRKLEDQVGKTYGLGWFQGRDGQVHCGVDEEELLTGYRRGMDYSKATKPWAEGVQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLR9</accession>
    <name>A0AAE0JLR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_507127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685048.1">
        <property type="nucleotide sequence ID" value="XM_062828115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLR9"/>
    <dbReference type="GeneID" id="87865269"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="366" mass="40683" checksum="3B4B9EC971380A3B" modified="2024-05-29" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFRNIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAIARVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTAAQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGLSDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMJ4</accession>
    <name>A0AAE0JMJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_9006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685724.1">
        <property type="nucleotide sequence ID" value="XM_062831540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMJ4"/>
    <dbReference type="GeneID" id="87868694"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF4">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042045173" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="300" mass="32970" checksum="D8FA1B140041FE82" modified="2024-05-29" version="1">MHTPTILSLVLLTLAGTSLPAALAVPHPHAAATIKCPLIFDGRIKIRTQLTDFDSSATSLFNPDNVKGSSLKWSQILKFPTDPKDLGRGSSRFDNCTHKPVEVTITDESVFKTQYGFRRAGLIFSGDTNTGSPASKGVKTLHFSVRQDGKRGLNLTHEYLNVWHETSDWSANQFNFQAGTIIGQEGSLPKNTFKIMSRENKLIWSTPIEKKEWQNFAITLDFNTNTLQVYYSKGDEPLRSVIKPVPNNNAGEGQYQIGILKKPTGTEDVVNSGYQESGIDEGQIYGGIFIEDSAGGCISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMP6</accession>
    <name>A0AAE0JMP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_143828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685366.1">
        <property type="nucleotide sequence ID" value="XM_062820976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMP6"/>
    <dbReference type="GeneID" id="87858130"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3352071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="458" mass="49100" checksum="36FD948B67EA66D6" modified="2024-05-29" version="1">MPTINLPAGSSTQLEPRPAHQHHLRSFAVDAYLGIAVTLVIVSIWCFKPRRRSSTPSSASYGSQPDVKEIKASLCCAKLVRPELTEGSYPKESSQYLVLATPSSVNELSHPLSSAYTKVPRASEHLQAMDGHDKGQLSDRSDPEATASLAVNKKAKSTSSSKYEACLWPQASSSVSMTGSSTPDRLRKHMPPPKTSTSTEGTTSSGSTSREEGRGKEHLQTQHRQIDGIGTSTAESLSYDGVQRQDDGLHGVSVGEPRLHFTRPPPPPPLTPPTLDKTAFAFQDRRPTYAASVPRGLDVSFIHQPNPDYIGHTSSVDILSSSPAEATGIPRRRSYTKSVPVGIPIPTSSFSSSTATTVTSSSAFSPSSYPSSSPLFPPPPPVPQDYQFVGGHVGHRASVGNQHQDEIEVHGEIISVTDDDGHGWQRHTQVYGGGVCLACLANGGGFYGPNVPLEDRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMZ2</accession>
    <name>A0AAE0JMZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_543476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685501.1">
        <property type="nucleotide sequence ID" value="XM_062829229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMZ2"/>
    <dbReference type="GeneID" id="87866383"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="575"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3354123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="955" mass="103538" checksum="8E26E78D6FCA1818" modified="2024-05-29" version="1">MSGTTFSYAQAAKGQAATQPSTKDDVSSATAVPSVTPNEAEVTEASEAGKTTQAPVEQSKQDAESLSVTAPATEETNKTTRENEAAPAQAQQQSEDKISRSVSRTSRSNESTDGRKGRKGKKARGSEKESQNEQQAEEEKEKVKEAPKVILSEAPLPAVNIWAQRQEAQAAKLKTSPAPTSDAVSAEAKKQDGESQSTPVNGVNGDKPHKKATDLPRAADQHQRRNGPRGARVDKEDKNAVALPPVADAASWPDPKSAASTSTEAPKEKVQEKTAEKESQEDSGSSKKKTWVTVDIQPTVVFNTPLPPRGSKTRGGARGGREQGSTRPHNTNATNASNATSQNERAPTTGGPNGHKRAGSRSREGNMPTRANNQAHASKRTSVDAASSKDARKLSVSANNEQARESGAETSTNATKKGSSVKEGQNEAGATSEAGPSSSSRPHERHHKGSDSTKDGAHHGVNGQQYSGREGRPERGRGGYRGRGGHNGTSGSHQSGYIGNGQYGHSSYQSRQHNSPPQHAGQFSGSYGQSSRGRGKWTGSNQNADRNGSAPAFAPRMAQPHEYSVPQYPVPYVYYPAYDPMVPVIRAQVEYYLSLENLCKDTFLRRHMDGSGWVFLDVIASFRRMRELSKDRETIRFACSLSEKVEFVIGEDGHERLRSKDSWSKFVLREEDRLEHLRHNGPTNYAPYQSPYHQMAPYGAPVIPQNYPVAATYAGYPEDQMFQAGYVNPAHYDPATNGSAVNGHQQLSAGVPDYAPPVAALTLESLTNLSDNAVEKMVVVLAYDDKEGQSSSEATAVAGYESSGSGHEQRNGANGAAVENGVNAAVWLDQYSPESANVRMDRQPYTVVRQAALNQRQKATTGETPKEMQTLYEFWSKLLLKNFNDKVYSEFRTLALEDASKEAPNKQGLKCLLEYYNNILLNNDIPKLWPQDRAAPELLQHHFQDALRADRAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNF5</accession>
    <name>A0AAE0JNF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">B0H65DRAFT_25020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNF5"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3354796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="231" mass="24883" checksum="7344F6CFF6D5E7AB" modified="2024-05-29" version="1">MPIISNLISKLVWADGQPPKTPQQQPTTPAPAAPVATTTTQTPTPASANASPSPSSDAVRYPPAQQWEERPYPPVFSERSMKQLGLFFGGATFFALSVAVSRRAVARHLKASKMEIFAPNMASGMARPGNINAKAPRDPMVAVEALNLATLNVVSFATMAAGGTCWAFDLLSVEDLRRKARRTLYGGTEANLDEEAEKEVAEWVAKTLGIDLEKAEEEAKGKMFEEAVKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNN6</accession>
    <name>A0AAE0JNN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_28592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686274.1">
        <property type="nucleotide sequence ID" value="XM_062822946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNN6"/>
    <dbReference type="GeneID" id="87860100"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
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            <begin position="10"/>
            <end position="113"/>
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    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
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            <dbReference type="EMBL" id="KAK3354896.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP12</accession>
    <name>A0AAE0JP12_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Casein kinase II beta 2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_35764</name>
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    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAUEPP010000001">
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    </dbReference>
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        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAK3355091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49380" checksum="68F3E9266C4D6831" modified="2024-05-29" version="1">MSPAGGGMWATAALRVLGKNLARTSKMLRSKLAAAATRSSNPAQQLQPIAVRSGVNSSRQPIHPAAWLRQQKSGRGGAKWHSTYADINATVRRYISNTAGKQSPSSGQSRFDRSKFPVSATSQAVAQFPGRAPFASTLRPNLTGGALPRTAGGYSFSGAGRAGGKRYFSHTPTAPAQVVQNVSQAVRAFWLSGQRAHFDGYSADGRKLYRAVSVDEEKARNKLAVAPHAPGSFIDFHISPSVTALSPLGAMIPSSQSVKAEIQTAGATLLADNFLDVLSVDFARTLKDLAAVMADLKALARLGDLPISLERADLLRVRFPGVDAETVERLCNDVGVQRGIIREDPDFDSDAGVQVALRFPYAPDNGCSKTLTSPNVTVRTRVSSESSELDDAFVEEVEENPWLLASEHSAVSEESEGYESMSPSLKSASSEHCSEDRYEGLEGIYKFLEECDRARVMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP88</accession>
    <name>A0AAE0JP88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_450271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686336.1">
        <property type="nucleotide sequence ID" value="XM_062825995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP88"/>
    <dbReference type="GeneID" id="87863149"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="410"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="775"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="831"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="608"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="718"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="779"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1144" mass="129620" checksum="94EE4E90D5FB4243" modified="2024-05-29" version="1">MDINRNNNSHNSKPKHISRLKQEMYQLRLKNNPFGSPPSSTGDHDTVSTTTEDLSRNLSAFSFNPDDEGTRKASEDYRLPTKRHATRSGRFGSRQQQEQQQATMLNTSAIGRAFPEWTGPINDTAPTTQNFDTNIAYNPYSEAKNRKENIRPITELTEEHLLNYGLDPKKKTRVEMQPRVENESDCSTILSRSPGRGARRSRFNNAHMENRAASPEVPKRSLQDIVSKIRTEKEANRNQLSQSAMPPKQSQPIHASLNAFLNSDLAAEKTNVGPTEGRSFFLPAFRHLPDWTSGALKFNTMRDGVPVFVKSGKNGVRLGQSGDHEPINAVGIPEEDEQIFVSMDKLQEEVRELHDHDAMLQREAEKLQREVNQLQSELKRYKTRRPSDSAIGSDSDGSFGRHAQANGYQLETQIAQLQNRLDQASRQVGVQDIHSTALAAERDEALHQASLARERAKRLQAELESTQKDLEFTLQYRKDKDSLQNENIALRTTNEELKQKNEALSQANQELSTKYDRLRREHMSAQKDLASTQEELASLRKKYDAILEEKKLIVQDHASMECNNESYFKETKKLQAQIAARDQHIADLKRGISTRDQMIDNIGGLTTNTAVIELNAELEAEIERLKQKLQQQQATRTNDRDGSISAKEGRIRVLKEQNLELECEKQKLLEENQRLRAEYEEMRNQWIDDRHKVVRLNQLLTKNNTEFLKTMNDNTEDCVRLEEDFKNKEATLRQKLERREAAIKKVKQLTAQINEISQRELLGKPSKVTRIVEPKDGTSTRYAASDLTGKSGTMNVDDDPTTELNLTQGTDFASIVDNEIARLKQTYRDFENQQRQSENDNTTQASQTGDAVQSKNQPAGILKKSSRFAFDEDTGRFSVKSAFSVASHHSDNESVKTATTSKSRRPSSMGVQGQETSRPASRVRRNSDNPTITTQTDKQSNIGQSVPALSKEARRVLDQICNHKSDNCNVCVRIAANGHHVSPSTEAPITVADMRKGKKTVRVDRPVPVSDRAVEDRGNYEEEPTMRPAMAPGDALAVLIKEIGDEIEHLQMELKRMNELYFNLDKSTGQRERRRLMGEIKKLQAELETKSGQLYKLHDVLEGQKDAGQLMDDSELDITILSDLLRVNGATENNQEASWNGFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP96</accession>
    <name>A0AAE0JP96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Di-sulfide bridge nucleocytoplasmic transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_451067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686560.1">
        <property type="nucleotide sequence ID" value="XM_062826034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP96"/>
    <dbReference type="GeneID" id="87863188"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="232"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="458" mass="51302" checksum="6AAA2A7DA559C553" modified="2024-05-29" version="1">MDRRGNESPMEWEFDSKPPVDHTSPYASLLSKQPPLSSFSSQPAKTSNHTFGATTAAPRSNLVNEHRDTLKPPNTSFNPQLHNKPTAPQFRNPAFTTPQKRPDEQTFDSPSEASPATTDISEMPPDTPEAMFNDSFKIPDTAYTPQPAGKIMFSRAYFRNGRQRKRKRQPGDRDVGSVRHRLDHGSDEFDSDWEEGVRPGRRRSSTDKNASPGWLTSFLDTISKYPAAPAVLSRWLQFVINTFLISVILFAVFSCVMAVRNDLSRAADKARSTLMHEISQCTSNYHKNLCAPKLNRAPALELPCNEWEACMNQDPSTVMMTQISARNMAEILNEFFTIISYKTWGFILSAFLVAIIGTNVGFGSLRDSGALRPSSPRKHAEPAPVAAPPPTPVHPIFSTPAFHNPQQAYIFAPIETPRRARQQFFDEATDTDNSPDVRMMLPPRTPRRSPSKGERRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPQ5</accession>
    <name>A0AAE0JPQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_535931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686576.1">
        <property type="nucleotide sequence ID" value="XM_062829038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPQ5"/>
    <dbReference type="GeneID" id="87866192"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="101"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="445" mass="50591" checksum="C7BBE1BB7AD4F731" modified="2024-05-29" version="1">MTTVVPLPLPTLLEGWTAEKDFKPIGKIAQNEATQRTIEPVGPHFLAHARRARHKRTFSEDDRIQAQERAKNVEEDNESDLSEPEDPMMLSRDAKDWKQQDHYKVLGLSKYRWRATEEQIKRAHRKKVLKHHPDKKAAAGRTEDDNFFKCIQKATEVLLDPIKRRQFDSVDEEADVEPPTKKQLQKGNFYKLWSNVFKAEGRFSNTQPVPSFGNENSTREEVESFYNFFYNFDSWRSFEYLDEDVPDDSESRDQRRHTERKNLNTRKKRKAEDNARLRKLLDDCSAADERIKKFRQEANAAKNKKRLEKEAAEKKAAEEAAAKKAAEEAAAKEAEEKAKADRESSKKAKEAAKNAVKKNKRVLRGSVKDANYFVEGDASVATIDAVLGDVELIQAKIDPDEIAALAGKLNGLKVADEIKAVWNEEAARLVGAGKINAGDLKALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ00</accession>
    <name>A0AAE0JQ00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I-specific transcription initiation factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_564522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687030.1">
        <property type="nucleotide sequence ID" value="XM_062830256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ00"/>
    <dbReference type="GeneID" id="87867410"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019622">
        <property type="entry name" value="Rrn9_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10680">
        <property type="entry name" value="RRN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrn9" evidence="2">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="754" mass="84321" checksum="DBE8782CFC6E265E" modified="2024-05-29" version="1">MSSHMNQEESEEDWDKDTEDINSIASDELHETRPNRWKGPPSTWLTFTAQERKAYQALEGLRRRDLSAHLYNAHALKTRVKRQKTEEATNDQTEDDQGPRHRENEWAPSHRWTAWPLRTGEVVDDELLPRTADEHEAFTLRRTVQTYPSKNLEEEISATILRCAKEKFRSRGFPEEDDEDDQSAVQPAGEGNDGVVDSIETGDNDDHHHAESSQLPSSPPRRNDESSRYSVPLSSPVKGEPVSQDENSKQTGSSSHISNSSRRRRRAPTPTYIPAPSVDDDRSYKLLRPASRRILSKLDETLTILHNARVAGLRDLSESSASDTEDNDNDAETEPVRQQQQQRTRRGRPRAPSPSPSAEATASESKPNPRSRRGRKRKVRIPLEGETEEEMLVRVARETHRRIPSFSRSRASSFHTTDDDDETASEADTEAVPPRSYQLPTSSKKTKRPTRDRSRSRSVTSTAAAAALTAVQEKDRMDRVARWGLRDWRDVLGAAALAGFPQSVIARATQRCSTLFGEEMTMHTLSSSKTKTTTYHPGDPLPESSDSEVDTADELEQRRTVSRQPSLVRTFSPPDDSQEDNQEDEVMEGVEAAPAEAGTEAAETERQGRGRTGRGRSESRARSRSRARRAGTPAPGLGGSGGLRVRRRSVTPAAGGDVYFCPYPECVRAVEGFARRANMHRHLKLVHGRSPPASPAGSVVGGDEDSMDEMDGGIHLDGFLQPIKVRKGWRGEDLMQRERERGRSYGRGEKKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQY9</accession>
    <name>A0AAE0JQY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Retinal pigment epithelial membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_505626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687136.1">
        <property type="nucleotide sequence ID" value="XM_062828002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQY9"/>
    <dbReference type="GeneID" id="87865156"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="661" mass="73124" checksum="EF52796208714B6A" modified="2024-05-29" version="1">MLDSNPLLDTPSPSKHPYLSGNFAPVQTCFPLTPCSYKGSIPIDLAGGQYVRNGGNPVINNDESARESHWFDGDGMLSGVLFRRVAATDEGGDGDETDTIIQPEFVNQYLLTDVYRFARANHHWMRRPFMPSISALLDPCTSAVRVLSKVLRTVAMVIFSWLPGWSKTKVKRISVANTSVLYHDGRALATCESGPPLRFILPSLETVGWFNGTTDNEPSGDYEKIDGAGAAGFGGKGMLSFMREWMTAHPRVDPETGELIAFHSFSVKPYVSYSIIQPYGVSTSPRLMSVPVPGMACPKMMHDFGVSRRHTVIMDMPLSLNPLNLFKGKAILSYNRAGKARFGIFPRYHPERVQWFETNACCIFHAANCWDTISKEEDLNACKGERLATTVNLLVCRMTSASLIFNTGNLPTPVSKTPIPPEYHEEEQCRLYYYSFSLTPRNQRILHQFALSAIPFEFPTLSPAHTMTQTRYIYGCTTTSPSASYTSALGKSVKIDALAKIDVSTLIARGAAPDNPSPPEPIKGCVDTRSVSDILTFSSSSPSLAEDDPIKVFTFPPNHYAQEARFVPRKNGVAEDDGWLLTYVFDESQIDEESGECSEGAKSDLWIIDAKGMREVVARIRLPQRVPYGFHGTWFSEEEVLGQRGDGSMSQPLEVLQVTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR10</accession>
    <name>A0AAE0JR10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium-binding protein cnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_70526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687566.1">
        <property type="nucleotide sequence ID" value="XM_062831301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR10"/>
    <dbReference type="GeneID" id="87868455"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041771836" evidence="9">
        <location>
            <begin position="22"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3356189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="577" mass="63945" checksum="DFEE9EBCAFC8EF5B" modified="2024-05-29" version="1">MRFNVAAAAASAALLAGGVSADDSQKVLKDESSSTVAEAATSVSPVEVPTFTPTKLKAPFLEQFTDDWDSRWKPSHAKKETGPDTEEEWAYVGEWSVEEPVVYKGMEGDKGLVIKNAAAHHAISAKFPKKIDPKGKDLVVQYEVKLQNGLECGGAYLKLLRENKALHQDEFSNTTPYVIMFGPDKCGHNNKVHFIFNHKNPKTGEYEEKHLSSPPTAKIVKTTELYTLIVHPNNTYLIQQDGETVKEGSLLEDFVPSVNPEAEIDDPNDTKPEDWVDQARIPDPDAKKPEDWDEDAPYEIVDEEASMPEDWLVDEPQTIPDPEAQKPEDWDDEEDGDWIAPTIPNPKCFEVSGCGPWTKPMKKNPEYKGIWNAPLIDNPAYKGPWAPRKIPNPDYYEDKNPANFEPMGAIGFEIWTMQNNILFDNIYIGHSVEDAKALADETFFKKHPVEEKLEEADKPKVEENKPSSPNDLKFTEDPVTYIKEKVDLFMTIAQKDPVEAIKFVPEVAGGAAALLVTFIAILAALVSGGSSPAPAVKKAAKDVKEKAKDVKDKAAEAVATGTEKAKEATKRNTRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR11</accession>
    <name>A0AAE0JR11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_536606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687448.1">
        <property type="nucleotide sequence ID" value="XM_062829049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR11"/>
    <dbReference type="GeneID" id="87866203"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="691" mass="78214" checksum="A9E8045E4AEB6D83" modified="2024-05-29" version="1">MAISFWPSAFTAHTQRLAFPSIAVIKEMTIAAFAASSVAHVPISTEAFEIANILNTPPEFQTMSLIDSSQEVGRVGNIKKARHMKAIIDTIIKDVTPTEVNKTTHESNIVDNCKDTTQSTDAQATAPLLIEDINSAEVAEVPQQVKLIQNVDIITDDHRDDTSSIAKKERFTIEENEKHTYYHARPAIEINEVNELFTIEENEKHTYSHVLPTIDIIEVNKSMASTITDVADVDDMGASASSIGHHFERFLKEDKMQWVHAVASQPELCITSPQTKKQAIKVTKSSTQDRKAIAADITPSTDNKKESISSEEKMVDTEVDIVHHARRLSNDTNSSTETDNTTDSDASNATTPDTPNTEYSTPDTSVIDSKFDEAALSSNNQPKQAEESQSPPTTPDASSFDNMYNYSHLPPSELEVTLIMERLDPNRRYVQMTCGYWYALEDDDEIRQMSKAEYQEFIEWTSQTPVITREDFDKKQQADAEQGIITSNAIAIIESLEDDDDKSGNEQQADLGSDEEDNSDNRPIELIDRESTDHLLTTLDQPQAGIELLDYTDLADEEDYNSSDPIAAWEATLATWKDPSDIGEDWGVVGLFHHPDGQKQFVMGNDEQVYWMYEGMFRLLNAHELDQFNRWRDGDEHAFDEPEPKREPKTWVRAVLGKRRKTNKWCAWSLEMESIEEEDEEDVREEDELWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR12</accession>
    <name>A0AAE0JR12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_585420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687181.1">
        <property type="nucleotide sequence ID" value="XM_062830927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR12"/>
    <dbReference type="GeneID" id="87868081"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000758">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF413">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="372"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3355803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="564" mass="62036" checksum="FEAAFA28D7849810" modified="2024-05-29" version="1">MASETMDRYGISFSPEIASSPVLDDTALLLSNPAWRGGTTISNTVIRNVTALTHKLTVSTRISENITVLASKYAATQNGVIQGLLYVPDLSEKDPCMDNLTDYIPETATRRAQLPPANINLIALVPWINAQCARHFLISARQDPVRGLIFYKPDNSTDKPPKGSSDEWDLGDGGKWRTQAGYPIYAMSGAAGQQVMDQLSLYSGNVTEIPFGDRIAEVYNSSPGDFVRVWTELSVSTDNDLPGIWVYILIIIGVLLGAVIGISLLMHFIQARRRSSLRRRVISGEVNLERMGIKRLKVPMELIDTFPLFTYHYEPDSISMPTSPRSLRPDRPRRGSRTQSEAPTAQSVSGLTAGTMSEKAPSTVATDYQPACAICLEPYQNRVTVIREIPCGHIFHTHCINEFLSENSSLCPICKACMLPKGYCPKITNAMVRRERAVRRLRDRITVEDSCSEYEMVDQGKPIRGGKGLKSLLGGRGDDSKATDAATIATTPSRMSIGQASSQRAGRKQQKQVGNNNNGNVQGGSPPELERKRMRELAGGSDIDDGESQAPGWERLRRKVFPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR32</accession>
    <name>A0AAE0JR32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_64567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687343.1">
        <property type="nucleotide sequence ID" value="XM_062831208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR32"/>
    <dbReference type="GeneID" id="87868362"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="226" mass="24751" checksum="528F065D08256C35" modified="2024-05-29" version="1">MGESDEEASNRLVALTSQIFVKDIPTHLSIMLPTLHTHTSTHISLPTILTSLAMQESPPSPTQSPSLITSLHSPLHQIPIHVLQILHIRLQLIHLLALLAQQLQRRLIPFIHLRHLPLQLSDPLSRLLLVLHLAHERHNLRPRLVPLLGDARQLLAHRHLLALELADLGAHALDELDRGSGGDGGYGDHVLHHVVWGRGGVDAVEAGVGAVELTGRVLDSRCGTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJP7</accession>
    <name>A0AAE0MJP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_339345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677148.1">
        <property type="nucleotide sequence ID" value="XM_062823618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJP7"/>
    <dbReference type="GeneID" id="87860772"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="319"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3334982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="529" mass="58142" checksum="7354767B65B63796" modified="2024-05-29" version="1">MGNSSSKDAGASSKNDDFKSYPSFSKSDTKDSSRSFRGLRSKIPGGSKSDSPRNSTILSSEEIAEKTNALNGKNGRPSVNTRSSYRRDMSPSPVTPSPSSPSSPSLDTATLASPTGESQPPPSPVHGAATGRHDVRAAQESGEVDHISDQPPSGGGGANPNQQPGQSILVKRENTINPVYDTPNQDPQNEQAVSGVAMSDIKDIDLDDFIKRLLDAGYAGKVTKSVCLKNAEIVAICHRARELFLSQPALLELDAPVKIVGDVHGQYTDLIRMFEMCGFPPHSNYLFLGDYVDRGKQSLETILLLMCYKLKYPENFFLLRGNHECANVTRVYGFYDECKRRCNVKIWKTFVDTFNCLPIAAIVAGKIFCVHGGLSPALGHMDDIRNIARPTDVPDYGLLNDLLWSDPADMDQDWEANERGVSYCFGKKVISDFLATHDFDLVCRAHMVVEDGYEFYTDRVLVTIFSAPNYCGEFDNWGAVMAVSTELLCSFELLKPLDSAALKTHIKKGRHRRNNMLNSPPAHFNPQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MKK1</accession>
    <name>A0AAE0MKK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12 15">Catalase</fullName>
            <ecNumber evidence="4 12 15">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_481022</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="2 12">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12 15">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12 15">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="4 12 15"/>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676685.1">
        <property type="nucleotide sequence ID" value="XM_062827614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MKK1"/>
    <dbReference type="GeneID" id="87864768"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08155">
        <property type="entry name" value="catalase_clade_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000050">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
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        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 15" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="9 12 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 12 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="17">
        <location>
            <begin position="71"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3334519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="765" mass="85559" checksum="1A1CE5D3630D03C5" modified="2024-05-29" version="1">MQRLALHYPTLDSAAEPPTEHILQQSNPTMSNIISQAGQKAKEALTSAPGSKKVDDLKNEFKETGKDARLTTDYGVKQTTADDWLRIVSDDKIGPSLLEDPFARERIMRFDHERIPERVVHARGSGAFGKFRVYESASDLTFAPVLTDTSRETPVFVRFSTVLGSRGSADTVRDVRGFATKFYTEEGNWDLVGNNIPVFFIQDAIKFPDVIHAGKPEPHNEVPQAQSAHNNFWDFQFNHTEATHMFTWAMSDRGIPRSFRMMQGFGVNTFTLINAQGKRHFVKFHWTPELGVHSLVWDEALKLGGQDPDFHRKDLWEAIENGAYPKWKFGIQAIAEEDEHKFDFDILDATKIWPEDLVPVRYIGEMELNRNPDEFFPQTEQIAFCTSHVVSGIGFSDDPLLQGRNFSYFDTQLSRLGVNFQELPINRPVCPVMNFNRDGAMRHTISRGTVNYYPNRFEACPPATHKEGGYLEYAEKVAGIKARAKSSKFKEHFSQAQLFFNSMSPIEKKHIINALSFELDHCEDPVVYGRMVQRLADIDIGLAQTVAEMVGGEAPTTTKHPNHGKKTIHLSQTEFPPATPTIKSRRVAIIIADGFDKVAYDAAYAAISANLAIPLVIGPRRSKVTAANGSTVQPHHHLEGFRSTMVDAIYIPGGAKAVETLSKNGRALHWIREAFGHLKAIGATGEAVDLVAKAIALPQVTVSNETEVNESYGVVTLRQVKPESFKDAVKIAKGAAGFLGEFFYAIAQHRNWDRELDGLHSMVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MND9</accession>
    <name>A0AAE0MND9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_582589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677946.1">
        <property type="nucleotide sequence ID" value="XM_062830860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MND9"/>
    <dbReference type="GeneID" id="87868014"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="168" mass="18955" checksum="D0E6ABF74D689FFE" modified="2024-05-29" version="1" fragment="single">LDVVDSGSKGSPTRGPDHASELDWPSGWVSGWFITKRRGGNIEELRSRLQIPLLAMLLLRLLLVLLLLPVGPDMFHNDGIHNLADVSTTKRMLFPDAVPYQEVAIMLAYFGVLIGGCYVRCLYRQASVTLLCRCWVTVGYCWYRPAVCLLLRDLFQALHFDIVHVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNQ1</accession>
    <name>A0AAE0MNQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ergosterol biosynthetic protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_434088</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677270.1">
        <property type="nucleotide sequence ID" value="XM_062825107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNQ1"/>
    <dbReference type="GeneID" id="87862261"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
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                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Mondo S."/>
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                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677855.1">
        <property type="nucleotide sequence ID" value="XM_062823418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPA0"/>
    <dbReference type="GeneID" id="87860572"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="315" mass="34314" checksum="FB36E42F3C8C200D" modified="2024-05-29" version="1">MLSHGFRSRVGHCVLASFPLPVARCPSPLLLLLMLTFFFYLTGQRELFSSCSSRSSQDYQHCLSYSCQISEYDASILYGTAGSQPVLLPVTPLSVSIPSFKTLITWGIVCCKSALSCCCKANHPPPPKQKGSQSWSDQGLQTTSPPVGKTGSRNGHAVLDWSTRHWAAASCRPLLPKGPSGPAFEPRQFQRTDLRLECIGSGMDWPFCLPINTLLLDPSGPFCCCTESSLLAPLFTSHPSQLLLLLLLLPFISRVFPHPRSPSHPAHCVVALLWCFPSGTLLTYIHTTYIHIHPPADPPACSLLPACAACLLLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPH6</accession>
    <name>A0AAE0MPH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_476207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678709.1">
        <property type="nucleotide sequence ID" value="XM_062827346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPH6"/>
    <dbReference type="GeneID" id="87864500"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115938" checksum="D31993E395131CB1" modified="2024-05-29" version="1">MSSPLPVPSKAALTALRGLVVGTSCTLALIAEDRRRRIRNALTAIENGERIRQAKNYNTGGAALAVALEEESLLDAGVLPLAPEPYAALPAEIIRQYDNARAAELERLRRGEDVGEPETTRREHDSGPHPCGHSRRETSRSFTPKKRTLTGQHHFIPPVEGTPITQTRHIHHRFSRKADNEGGRSSLAFPSNDNIVVMIQEACRTKELGQMEKAASLIFEATNQNQAPGNLDEAWMEASALLCRTYLDLERSEEAAKILSTVLARAPLTEARYFDFQPVRLIESLLAKATQAKTGENICPAKLETAISLFLPRFTEKPVVQSAELLAVGRALLDHAFAVGKSTRAIDVYWRCISVSESQYDFTSWVITKLHDTGDYKAAIRLFLANYCKMSPSAPSIIRIAGPLVQCVEKAHNYKPTQVLKTLLNIASGKCQLKTEWIMRLLTAHWRRHGSFEELETFFQQLIELGLKDVVYHLDGVYRVMIELALEAGEDFKAESIFAQASTELPQLAHDVRLLGIFARFKAKQQDWEGVRESFGAMKLDSKPALDACGTAFVPVVKTYAKDHTVQETDAFMRSYITDLKVPLSRFLVTLMAKQYASIRDLESFVEWLEYCSTAGFQVDAAFTNAVLVSCRRNWNVPFRDLRTLFRKLRALNPSFVDRHTERVMMDAALSSDNKLDGGFARGRVLSLRVTPNMGPVRGKSDTEHEVSLAMKEALSYRHPAKALSIYKRALHLGMPFSECALKLAVNAQLKLETRPYKKTYDLVLKAQDQGNNVDAILNYLLGLQLNDLAAKGGEIRSIVQTAIDRIKEVGLKIADTFLHRAALICLMSGHFEGAHHYALMAAESSNHSEPCYNLENFRIMLYSFAGLLNIDGIRHVLAKAMSSNYKEHTGCLKALKRAREMVMEARLNDAKTQQRHDAYDVLSEGIDKIVESRQRLQSQRVKLGVESVRIMRQAALDASGALVDFAEIPWLNSKPRIRQDDEAELDFEEEFRRQQQEEEEEGRAVFDELLVLDSAYPTAGGKMAGTGAGLAQPVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPJ6</accession>
    <name>A0AAE0MPJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_579625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678170.1">
        <property type="nucleotide sequence ID" value="XM_062830770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87867924"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="632"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1032"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1562"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1567"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1592"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3338810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1779" mass="199248" checksum="7B4519000E596A89" modified="2024-05-29" version="1">MSSLKFVTSSLDVIAANAGKNKELAELAQKAQEAIKTNDQQLPDPEVIFAPLRLATKSGTIPLTTTALDCIGKLISSTYFSVPSGQSAAASEDGQPQQQYPPLIERAIDTICDCFQGEATLVEIQLQIVKSLLAAVLNDKIVVHGAGLLKAVRQVYNIFLLSRSTANQQVAQGTLTQMVGTVFERVNTRLHMREARANLSKLKPSQSSFNVNGSSDGQNSTQEEGNGDQEEATHEDAQESQPQHGDGNGEGPKLTLKDLEHRKSFDDSNLGDGPTMVTQLKPNRKPARSVSEQSVPESSQEDSPESLDAEDEVYIRDAYLVFRSFCNLSTKTLPPDQLYDLRGQPMRSKLISLHLIHTLLNNNISVFTSPYCTITNTKNNEPTSFLQATKYYLCLSITRNGASSVDRVFNICCEIFWLMLKYMRAPFKKEIEVFLNEIYLALLARRTAPLSQKLAFVGILKRLCEDPRALVEFYLNYDCDRNVDNIFQRIVEDLSKFATSSTTVTALQEQQYEENHSKYGSASEWQMRNVLPPPLTVALIAQNTDTDGDIPKDYVLKRQALDSLVETLRSLLNWSHPGRPEVITTGTGISERRPSSDEIRESMDPSIMGESLSRLDTPTMPSTPLLDDDPDQLEKEKQRKTALGNAIRVFNYKPKNGIKLLLKEGFIPQDTPEAIAKFLISEERLDKAQIGEYLGEGDQKNIDIMHAFVDTMDFTKKRFVDALRQFLQAFRLPGEAQKIDRFMLKFANRYMLGNPKAFANADTPYVLAYSVIMLNTDLHSSKIVRRMTKEDFIKNNRGINDNANLPDEYLISIYDDIAKNEIVLKSEREAAAAAGTLPAQSTGLAAGLGQAFSNVGRDLQREAYAQQSEEIALRSEQLFKDLYRSQRKNAQKMGGIKFIPATSFKHVSPMFDVTWMSFFSALSSQMQKTHNLDMNKLCLEGMKLATKIACFFDLSTPREAFISALKNTANLNNPQEIQAKNVEALKVILELGQTEGNLLKESWKDVLLCISQLDRLQLISGGVDESTVPDVSKARFVPSPGTDSTDSRKSMAAKRHRPRSNTAPQGVSMEIALESRSDEVIKSVDRIFTNTAHLSGEAIVHFARALTEVSWDEIKVSGSNDSPRTYSLQKIVEISYYNMTRVRFEWTNIWDVLGEHFNRVGCHVNAAIVFFALDSLRQLSMRFMEIEELAGFKFQKDFLKPFEHVMSNSNNITVKDMILRCLIQMIQAKGDKIRSGWRTMFGVFTVAAKDQYESIVNLAYENVLHVYKTRFGVVITQGAFTDLIVCLTEFSKNMKFQKKSLQAMETLKSIIPKMLKTPECPLSQKQNSDANAAEMALNTATKPAGQQTGTSVEEGFWFPVLFAFHDVLMTGEDLEVRSNALNYFFDALLKYGATFPLGFWDILWRQQLYPIFMVLRSKPEMSNALSHEELSVWLSTTMIQALRNMITLFTHYFNPLEYMLDRFLELLALCILQENDTIARIGSNCLQTLILQNVEKFTHEHWQKIVDTFCELFDKTTAHQLFKAATISTPLSASNGLDYTSQLSPSADSADADTRSLKINGADDAASETSSIHHQTPHTNGGIGTEEDSHSSVHNRLTASTALSSHPPNSPGGGVGLEEFKPSNPLQQQPPVVTAARRRFFNRIISRCVLQLLMIETVQELFSNDSVYSHIPSPLLLKLMSLLKRSYLFAKRFNADKDLRMRLWREGFMKQPPNLLKQESGSAAVYVSILFRMFADTSPERLASKGDVERALVPLCLDIVRGYVSLEEESLEAGGGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ54</accession>
    <name>A0AAE0MQ54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_430991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679399.1">
        <property type="nucleotide sequence ID" value="XM_062824919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ54"/>
    <dbReference type="GeneID" id="87862073"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="176" mass="17939" checksum="689CA54D8F9812AD" modified="2024-05-29" version="1" fragment="single">TIKTTLPPSTITTTSTLTATTTSITTPTPTDSCTPGVCGTYTFHPCPSTPLGACLCGLDPDGQAFCSLDDWCQNEIGCDTNAECLTPESGQTGEGFRCLVGSCCVYEVVDDGQGEGSVVKKKGKCVKEWGAVCLNEGTAEGVLKLRGGSGVSRVGRMGRMAAGGGGGRGVSNGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ88</accession>
    <name>A0AAE0MQ88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_263591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679504.1">
        <property type="nucleotide sequence ID" value="XM_062822656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ88"/>
    <dbReference type="GeneID" id="87859810"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="417" mass="47904" checksum="CA88EB4A6493DD65" modified="2024-05-29" version="1">MPRGKAGTGRLRPIFRGLNIAISGTFHDQWTDTKISRWVNLRAAEFSWRMSEDVTHLVCTKEEFDKKGPKVKQALARAYKKDKKCHIVSLDWLEDSLFKEKRLPEDKYSHVATLKALRDKARLEKKIAKGVEEEDRAVNENFYNVYWDPTDFFQYNITLSRDDEEMGILGERYVVKFGPFRLERQLTSRKLYESNALPHLYHVGVRYYKSKKDTIPKLHRLSETPRDFQREYESFKRFFEIKVGYPWDERLIRGVGSLGAKFFSYQPPTGGKPVGWVPEEYLPKEPTPPREEEVNTSSESMPNSQPTLVPNPEAEINPGSESMTSAQLVLSLRPKVTHEEVPTAPSQEGSQDQTHQNDHNQHHHNESQLTTISPHTPRHDTQKNTLETCCYMKTAAAEVSLPTQTADPTGGNATESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQU3</accession>
    <name>A0AAE0MQU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_262899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679475.1">
        <property type="nucleotide sequence ID" value="XM_062822639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQU3"/>
    <dbReference type="GeneID" id="87859793"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="2">
        <location>
            <begin position="467"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="709" mass="77891" checksum="120093AACB6AAD11" modified="2024-05-29" version="1">MAAYRRGQPSLSVRLPQPSASAVLPDLPPISALFLIDFDVKAGYTIVWKQAVPGLELDGVVEYKSLPSGLHTVTDDLVYFVHEGGHAGLSAFVNARTDEEENRHARMIAVGVLVPLAYGRLGRSWRHADRLKDIASKLVVDRQQTHLLEDYWAQNGIRDGAHPPPLAEAALDSPALSYKGGRPGPAKGHSRNRSESDGTVLMSSSHRLSPYHPAWSLTSLLDTFGPLIFPIHRAALLRKRILISTHAPVHEACNFVYDLSVLSNISLSVSDLVDPAASTQRLRPLFNIGVHDIGYLLEHHAAMKRHFRGDNHETDNDFASSIAAEEAGSGWVACTTDTILTIKDSLWDMLITLPPPHSGNAKERMWPTVECPKGVPVKATQRDLRRFKWLKMSLARIDPTSMTTPHIPRSPLSDRTGQRSVSTPLAPNRTPTISLSRPTETARPGTATSQTPPQTRANSDDDAERVVEPTTWAALAYSGFIWWASAGEQGHSDEVDELAHDSALLADLTGNTPKMTGRTPRKTSFGAASSTGNNIGERGIMESVLSLTAQRDGAQETSDDEQARIELAIIAYFHRLTTSMLSVLADLVNSADDDDLLDLDIDPNAVGEEEYRDDYNDDDDQTGLLYGQEQSGIQGSRREGEGEEEEEEAEYEGSLQGWVRVDSEALAHMGLDVWSKSDADFVSELTKRYFRRRAYVENKGVEVCGLKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQY4</accession>
    <name>A0AAE0MQY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_444650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679610.1">
        <property type="nucleotide sequence ID" value="XM_062825694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQY4"/>
    <dbReference type="GeneID" id="87862848"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="177" mass="19466" checksum="1D4C8EFE1DCA9460" modified="2024-05-29" version="1">MACGIKTYIGLASELCSICAQPFQSFHVLRITTSSDLFGREQGSSLHQSPRMAFGRQHILHSQEHAVFGNLSLPLPNAGALSRGTYTVKPFWPDHPLPAGRHANGMAWDSPPRRTTTSRSTFHRTDASALQAQATLWPWRTEDYGAQSDVQGVPATENNDQQKNPRACKDALTRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR25</accession>
    <name>A0AAE0MR25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYG1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_236493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680796.1">
        <property type="nucleotide sequence ID" value="XM_062822266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR25"/>
    <dbReference type="GeneID" id="87859420"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="366" mass="40819" checksum="9BB53B7FC3C4D2F7" modified="2024-05-29" version="1">MFTRPLAFLRTMAENAAKRIKTDGGALTIGTHNGHFHADEALAVYMLRQHVPKYTGARLVRTRDPALLETCDIVVDVGGEYEPARDRYDHHQRTFTTTFPDHQTKLSSAGLVYMHFGKGIISRSLPDTPAEDSDKIGLIWNKLYDSFVEALDAHDNGISVYDSDALKAAGIEKRFSNGGFTLGAMVGRFNGNWNDPVPSDPVAAQAEEDGRFEQASQRIGEEFDRALDYYTKAWLPARDVVETAYKARKEYDAEGRILVLKGQSAPWKDHLYTLEEEEGEGVQKVLYVLYPEKPTPDAKWRVQCVPETGDSFQSRKPLPEAWRGFRDEKLDEITGIQGGVFIHAAGFIGGNKTFDGALAMAKKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRC5</accession>
    <name>A0AAE0MRC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681437.1">
        <property type="nucleotide sequence ID" value="XM_062830542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRC5"/>
    <dbReference type="GeneID" id="87867696"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="212" mass="23676" checksum="5D504CCEC4F927DE" modified="2024-05-29" version="1">MSRAETSETFETVVVSQWLRLFWKTQQLATSGRHTEAHGREGGKPFTPPPDVEPFAVLFRLLISVYQVFSTRITSMPTVGYLSSLPEFSASAHGHANDLDHLSGMSHSTFLVLWYPSFLADLSAVATERLRFAAAVGRQAHKNFPDRASFKSCTIHRSDRIPYTNSDANLFHMLSFSAVLLHDSSTPYLSQTLQKTVVSVSFLRIRQTPVNG</sequence>
</entry>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680045.1">
        <property type="nucleotide sequence ID" value="XM_062824778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRC6"/>
    <dbReference type="GeneID" id="87861932"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="136"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="314" mass="35440" checksum="C551BDECCFA5C20F" modified="2024-05-29" version="1">MPVGVDNIPLDTVPTLDDTPGLPRLKYNMMDYKWKLIVVSSLLVIESSLLPIALFYGLWYGTDLRHGIVFAIITAFFGLVTGIEFGLRSLKLILSRDEYRPLGTDPVKDRWKFDFTHMTLSFGYTYMTGILIGASIPHEPIVKPLAMPVPLFFIQMGLQLLWTGWANRKHKKAPCRISSVPKGGRVPPLVLTIVEDIVAVDGAGGKEYRRAINARYEVSKRFREMVARQNWFWGVGALVDGVATMIVIWTIPQEIAYGVAWASPLIFSAIWTVITVIWVRRDLRREKAEWRANSEPSLSNAGTDTQEMQERSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRD2</accession>
    <name>A0AAE0MRD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AEX-3 domain-containing protein</fullName>
        </submittedName>
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    <organism evidence="4 5">
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="87858741"/>
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    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DENN_C"/>
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        <property type="entry name" value="DENN_Domain_GEFs"/>
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    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12296">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="86"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="917" mass="103156" checksum="68E5A2E999816888" modified="2024-05-29" version="1">MPSLNTHASFHRPRTSDRDARPGTRDQADVNPAIPSRSSSLHSRITQPMPNSLNGKPQQRTPKTLTHAYMVCGVGREPSQWVKAPAPAQGKIGHMKGAVGQFWLPEILGSSPRLEQDNEIARALHNAMRACFPHDVEICTGRSQPHCVHHAFVLQQDSSHTLYGICLRVWSRADEKRAETIRELRRRTEPDFFDNPDEQYWIPYCLSFLSRYPLYNLLGDYLRGMWIHWNKATNLFHAEEVSRILSFPAPRLNDLVRIDMKDYALCYQFPSSPTGFQNFAMWPLFNCLSIPNIVGVIEAAISPTRRIIFVSHYPAMLTMAAETVRFAVRVYEWSGLYVPIVHARHATQLAEEPGPYILGITAECRSLFTPPADALVVDLDRNFVLTSSPPTALSPSQRNKFVTRLTQALNGDVTPSGVPPHLRSAYGGGKLIPAGQIIVMRGEVESIQDPDWWNQDAVMSVMDHVCEKMGRNTGIKAVFGGSAKKPLMTKVSMRHLNEIVRERNQYSRDAMEAWQDFINLKGRMETELSKVTKRNNYLNDELESWKQQFLKFQTFAETLTKETQDLKAKIENSKRENRRLGSLIEEHRSDYNRLQMRLQGTEKQRDDALEALVLQQEIAEELERERKRNRKELTALQHTNNTITRQRDEARRVVLHLRSLISGQHHHMEHIVKTMTSPQELAAEIEAGFVAAAQEAEEATAGEEPNNERFIKNLTLASKRISSQTFVDVADRHLKDKTDAIAHIIRNIAEQCQAAVDGLQLAQDAELGTHHEPLSAKGAGMYSKSRRGSNLSIAHSDDGATSVATTEAGDDSFLLNPDRSGRSSIPPTPDLIPNRSSTSMSIASTATTPERTSQYYSLGHHDIPTRILEDDEDELAGERSESENPIPHEPSVRVGKHAESLIHRPSGARISALGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRI6</accession>
    <name>A0AAE0MRI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_548784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681648.1">
        <property type="nucleotide sequence ID" value="XM_062829600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRI6"/>
    <dbReference type="GeneID" id="87866754"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000149">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="139" mass="15813" checksum="0352FCEAE6365A20" modified="2024-05-29" version="1">MAPSKTPQPPYSKDERVLCFHMEMLYEAKILDVQPTESGDGWSYKIHYKGWKSSWDDWVPQDRIRKLNDENKDLAQQLLAQYKQLQSGKAAKQPKKGGRPGGSDLSSARGSEERTAAGTTTQNNRNPRRARDFDLETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSL6</accession>
    <name>A0AAE0MSL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_573088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681365.1">
        <property type="nucleotide sequence ID" value="XM_062830536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSL6"/>
    <dbReference type="GeneID" id="87867690"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="165"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3344752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="407" mass="45538" checksum="BCBEE68870AA2108" modified="2024-05-29" version="1">MPKRKSADLSLLTIPEKIVELSVWFEGLTPSFNFDVPEKVMMAFTFRRWATHFRTLRHADWLKHNVLPKARELAPKIPEEDAMTIKRLLEEIKQEVLEASARDDENAQKILRRTPEEGLLGSEYPCEQYQRAEGTPRRTAPSFIHGWRPLPNPKEVPRAVRGTCATGSQDGSVVSRLLQSPSFYRLRALTRSPTSPTSQSFSSQGVEVVSADVNDPSTLGPAFANAYAIFAVTAYCPSFPTLGRHGAGEEELQQWKNIATAANKVEGGYIVPLPGNPDTLLPYTGDLHHRGNIGVVVEAIINSGPKAYGKIAVRATDYVTWAEGYKAIEKLFPKKRIAFSKIEHNQFIKLWGEWGVEIADQMAWNDEFTDWKGLAGERFLGFEELGIKEGDLVGFHTALEGLKEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT64</accession>
    <name>A0AAE0MT64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_441485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682986.1">
        <property type="nucleotide sequence ID" value="XM_062825529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT64"/>
    <dbReference type="GeneID" id="87862683"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="142"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="303" mass="33539" checksum="D57204A3D20E490D" modified="2024-05-29" version="1">MPPKKANATNRVTKGGRLGHGPKWTPFEAWNFDRTARETIPGATCKQIDSFYADPRRWNAAGRPQRPRLPTLPKTEAENESACITDRARAALAEPVDALGVKYCYTCFECGRNPDDPACGVQCYDEIHSGGGTTGMKTFFKKWLEIRHTGTADKGYGVFVKTNGRYEIPKGSYLGHYVGEIVPGPSKNNMYLYEPQVGLEWDTDRPIVDAGKMGNWTRFMNSSCDPNVGEAIMQIGKVRVIAFFANKTLKSGDQLCIYYGDDYFTGHGLQCTCDEFEGPHDPTVVGAGLKARERQQQALGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT95</accession>
    <name>A0AAE0MT95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_204693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682010.1">
        <property type="nucleotide sequence ID" value="XM_062821852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT95"/>
    <dbReference type="GeneID" id="87859006"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="181" mass="20312" checksum="60C21121FC76B255" modified="2024-05-29" version="1">MRLPYTWYMDCHQQNNETYAESNRCTFATFLPLSASSTPFLPSISVFLVEGKHVVVDGGDGGEIHMLSIVRCIQPIDTFSCSLIPSFPCPLALVSVTVRYTLFALYFTLFDLHILFALRFSLFGILFKPTGKFPSDHRDFLGRPSRWSRSSISVNNAALSRQALKVPKFASAMQSTLLFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTX7</accession>
    <name>A0AAE0MTX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_506476</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684273.1">
        <property type="nucleotide sequence ID" value="XM_062828064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTX7"/>
    <dbReference type="GeneID" id="87865218"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042253164" evidence="10">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3350978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="221" mass="24824" checksum="042492FF881F066D" modified="2024-05-29" version="1">MKLSTITCALLGLASEVAATALTYKLVANEKACFFATTKKPNEKIAFYFAVQSGGSFDIDYEVTGPDGNIIMDGQKERQGDFVFTGKQIGDYKFCFNNEMSTFAEKFVDFELAVEDEARVSIPSKQGSSPEQTSALEESLFKISMQLSTVTRNQKYFRTRENRNFSTVRSTEKRIVNFSLIQILLVIAMGALQVFIVRFFFQAGLRMLTYLTTQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTY8</accession>
    <name>A0AAE0MTY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_106349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684303.1">
        <property type="nucleotide sequence ID" value="XM_062820492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTY8"/>
    <dbReference type="GeneID" id="87857646"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="315" mass="34453" checksum="65F3FE484665071D" modified="2024-05-29" version="1">MLPLARHLPFRGIGDQQSCQQPGSCTTGAAVSAPKPSNGRLDLQASIDVETAGQFFFLRVFSFFSFFHLLRTSRDLFLRGVSTLLSPSTLHGTPKAKGATPVSTLSSDPAHQGHEGTPFLSRHLCRPPNFLSSCEASCVGPQIDCWFPIGPPGSQILACLRPIRTSAQDSTVCYLSTNVAHAYARSTFLGTTDDQTLGTSLRSFLLFAGNTFRTHTRHTRATRLQQPSSLSISTNALTDIEVNLHAYRPLLDHYHLGGPVTRHNTTPREATDGSQKWCFTALVFHYCCCCKASRVSQLSAAVYAISVRLLVYIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU28</accession>
    <name>A0AAE0MU28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_108080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684393.1">
        <property type="nucleotide sequence ID" value="XM_062820525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU28"/>
    <dbReference type="GeneID" id="87857679"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="485" mass="53606" checksum="B5CE58018C65FF98" modified="2024-05-29" version="1">MSSSKPSAHPYSLPDLTETKLSVEDDWTKVKDRKEKKRIQNRVAQRTYRHRMKARLGELQQKLEYHERNKGTSTDGDAPGVGDGEDTNRSPSVQLPTPAYTTDNSPSPRANEELVVFDDIHLHNYHSPHAFHTDASQLFDLSPVTTPLTTQPPGVFTVGQSNITDSGYTSAVVHEYLRLQMQPFDTQHRVADGQANNYALGVSVHGGDSFLVHDSPNVDPLLFSIDGHDTMTVGFTEEDESNILNWKIQPPATPNPGQVALSPSVAQDLPEMKKTRTSNRTTCTASAEVNHKAPTQPASLPTKRPTLDERMESVMERVETAGFDSFDSLATLYYKAKFGDSSSLAVEQRLSRNRRLPKLFADVFSAAQEWGAREQRPLFDEILRMSEGMLISEARGVHSTLHASIGGLARSAKDERTGKSAVPGLKRLMESNLPNLWALVTALATENRAVRQRDRSNTVLATILVLQSSGQLPKQSLMALLEACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUC2</accession>
    <name>A0AAE0MUC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_99605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684111.1">
        <property type="nucleotide sequence ID" value="XM_062831673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUC2"/>
    <dbReference type="GeneID" id="87868827"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001144">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="539"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="752"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="921" mass="100814" checksum="72F17E5F85DA22AC" modified="2024-05-29" version="1">MAYRQTTTKTTFEVNNVIQPIFTGGSVALDNGARILATTLGEQAVLTELNTGKQLAEIEGDGEPISTLTITPSASHLIVCSRSLTMRIYSLKVSPDYDSIEATLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIVGGYVTHTVSGPSVLISALHFFEIAALEDQASNKNKKNRRKSTADEEQAQDDSVASKFRLAYGTQDGKIRIFDLSKRKTYPVYADPNSRREAHESNVQSLDYSPELHALLSGSRDKTMTVWLWKEGAWRGTPMLRHEGVEAVGFLNNGSLMYSAGTSGLLRLWDTTTHQEITAKQDAKSEAESIVSAFALPHKNLVVCALSDFTLALYRTPSAADAMKKSTKPLEPFRRISGTHDEILDLVYLLPDQSLMALATNSEDIRLVSVADKQPQLGDEEEGAAYFGHDVALLKGHEDIVMSLDVDWSGHWVASGAKDNTARLWRVDPANNSFECYAVFTGHIESVGAVALPKTVPPENSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRTSQKGAVSTSLRRLAHEKDINALDISPNGKLFASASQDKTVKIWDSATLEVVGILKGHRRGVWTVRFAPQGMPAIQGETGTAVSGKGVILTGSGDKTIKLWNLSDYTCLRTFEGHSHNVLKVVWLRLPKAADGEDEAAAAATKAKQRIQFASAGADSLVKVWDANLGETECTLDNHEDRLWTLTVHPKTNMLVSGGSDSRVTFWKDTTAESHAAASSAALKLVEQEQQLENYIHAGAYRDAIILALQLNHPGRLLGIFTNVVTTNAPEEGSLSGIKAVDQVLGNLSDEQIFLLLLRLRDWNTNARTAPVAQRILWALVRLYPANKFSNLSVKGARGQKSLKEVLNALRVYTERHYKRTEELVDESYLVEYTLQEMDSLAPPAIEERDGDLVMADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUI4</accession>
    <name>A0AAE0MUI4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_98834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684079.1">
        <property type="nucleotide sequence ID" value="XM_062831659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUI4"/>
    <dbReference type="GeneID" id="87868813"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="77"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="615" mass="68044" checksum="571F221BBD44202B" modified="2024-05-29" version="1">MATDIINQEALAPPSMMQEAPSPTSSMTPLPTPNSTSFPKDSVSPSPSTPANGNKNHSQSSASRRPPRKSTLTQQQKNQKRQRATQDQLTTLEMEFNKNPTPTATVRERIAEEINMTERSVQIWFQNRRAKIKLLAKKSLESGEDMDSIPESMRQYLAMQAMESGKGLGYFGRTGLLPYGHQGMLGGEQGGQGKVLIHHLTCKSLTIGKWMRVSQNSMDLIIFYSPDKCTMTYYINNEQEGYKIEYPFSYIKNIYLNNGDGDHMGGITIELLSPPLFFMDAAGQASGFFQVGDFTEDQQASSVLTHHLGGNPKILSGQLAKLVSLEAFMHRHSPNHMFQEMHHPMALSAPVSPARPSSQPNFAQPHVGMFQENQWGINVHQNNNMMMRGGPGHKRQRSRSVPGPIDFQTLQMLQQPPSFHITQPEHHQAPVHNPQIFAPIPQQPNMLGPLNPNLRIDTQAGFGSLDMRQYPMSATTAPHSPAGFNSPNYFAPPDNGNMAGSFTPYSATFSPMINPSSLGVPPPSISPLSFDHPAIMSESPPMSMPPICEGSAISDDGSNHDMYQPGKHSYTLPMHPHSPFAEPNQAEMELNQYMDLKHFDVDPASLSPESIHHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUN8</accession>
    <name>A0AAE0MUN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_567826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684259.1">
        <property type="nucleotide sequence ID" value="XM_062830376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUN8"/>
    <dbReference type="GeneID" id="87867530"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1155" mass="125904" checksum="A07AA75292F5F20D" modified="2024-05-29" version="1" fragment="single">MMSSQSKDNNNNNNNNNNNNNNRDRKSKSIRLSQKLRGLRDLRLRVSIEGKPHLLQRRESIQESPHQEEEEYRIVHTPDRPQRFISPVEAPTEDDCYDALRTWHHAAEQQRSGIYRDGIQQQRSGGAGEPRSTGVGGGTNDDDDDGSRGSPFVPDPNDDAKTPKDQKWWELAHRESKEIGGMNPFREWGGDQQQQEAQKRSDDIGQIVRHDTAKGGPSQRGIAPPHLLTDFTGLLPKTYDTSEAGKNDMFNGASYSKEGEYTPSVYTPYTPSQKSPATPTPEMFPKAPTGTTSESPPAKSTTAAPETLLTRDIQPVRVIDSDNESPSAPPGGRYFDVDEEYTPSGTGTSKSSVSGKPTTTYVADQQQRPKQPQPPPPPPPPKPLGNTGRGFLIPSLDFSNQTQTLHSELLKLAHKQQQQQEQQRGRGSGQSGESGQSGSTSSAFYSAFTSSPRPDTPDLRPPSRRGQGQQQQQQQASPNLVPPGGTGTGTSTPATPRPKKQQQQKRPPRTPPRGFLKERGPYISPSKGSRPSSSGMSSMRPPPKTTEQQTRSPKPSFLLNGLDFSPSRPVPPTPFATPTKSEMPLEKTLGTGTLGEHMGGHIAGAISTSSLSLLASLTGSNGSVITPPRLSPTKPKPLPPPPAPPSPPELLTLPATVYSGNSKAKMPVIAPVPVPVPVPSPLSKFNTTYALSSDPSTSNRLPQSQEQSQGREQEQTQQSSPGFSEYIQQPRISDPFVDSPTSDVDDRLSVAMVNGLYNKEQAQAWKETMAMMVQAQKQERQKPVQVTVQPQKKQAGGREQEQGNTRKQQVSGQARTHQVQTENLGKKPLQTQTQILQPKVQETVNAASSKNPPRTPPPPPQTPPRSPAHPPETKPQTPSPQFQAYQPQPTPRTPSPRYLVFPPHSQSQSQSQPQQQLLQPAPAPSPSPQPHPSPALSLLRPIYPGSGSPFPGQTHHIITPPPPLPQSLRTRTRTVNPPYRHHQPAPSFRKQSQGKKEMTDAKEKEQKNTSREHQHQRRPVSGSSDGCDSDSSYESLQFWKTPTPTPTPGPGPGMTAPVQSTSGTSRGNQQSGQPGHGGFGGRYDFKEEGDEDEKEKKQRDDGGGDEFETETECETETETEGGTTGTGKDVVVSGVVDDYADIIDEYAGGWRETMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUS4</accession>
    <name>A0AAE0MUS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_440185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684561.1">
        <property type="nucleotide sequence ID" value="XM_062825467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUS4"/>
    <dbReference type="GeneID" id="87862621"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="131" mass="14183" checksum="F00ED40EE9FA6FBE" modified="2024-05-29" version="1">MADASKTNDLKFINTFQKDLERNAASGKKTGTESMSSFVKDIDTIGKASTTTTTTTATATTIEGNRTTPNTNEPQADANPTTEARHGHEICPNPLPWSPYQHFQGPMCGCRDSNWCHGGTTAHDQNETNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV75</accession>
    <name>A0AAE0MV75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_132838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685041.1">
        <property type="nucleotide sequence ID" value="XM_062820831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV75"/>
    <dbReference type="GeneID" id="87857985"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001558">
        <property type="entry name" value="Ribosome biogenesis GTPase Lsg1, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="175"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3351746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="654" mass="73251" checksum="3AEB5D09A23ADBE6" modified="2024-05-29" version="1">MVLAKSKKSVGLGNTLMNDRFGKGKGSDRKRVSAVTRIDHATGKEYITNDKQDAAWVKMRSITEQGALDEFLATAELAGTDFTAEKMNNVKIIHTDQRNPYLLSAKEEQAVLGKQRANKGRLTVPRRPQWDSTTTRDELDQRERESFLEWRRGLAELQETQDLLMTPFERNLEVWRQLWRVIERSDVIVQIVDARNPLMFRSEDLEVYVKDVDPKKHNLLLINKADLMTYKQRKMWANYLKGEGIDYRFFSAQLAKEMIEAGGYADSDDDESDDESDAGEGPSNKEEAPKAEEKVSEEKEEAKEEEITEYNDPDTHILRVDELEDILLQYQPKDLDRKLQVGLVGYPNVGKSSTINALIGAKKVSVSSTPGKTKHFQTIHLSDNVLLCDCPGLVFPNFANTKAELVCNGVLPIDQMREYTAPAALVARRIPQPFLEAIYGIKIKTRPLEEGGTGIPTSDELLDAYARHRGYMTQGLGQPDQSRAVRYILKDYVNGKLLYCEPPPGSGVDGPEFNAELYDMGHLPENRRVAMMSALEGADIDDTATLTSEMTALALPQGQKSKKLDKAFFKSGGNGGHIQQNFHHKYTQQGQAQSIVKHMSGRKLRAIIAAEQGVDVKEVQMEMGGKKHFKGGMGLKGGKGKRRAGRSGNNDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVE0</accession>
    <name>A0AAE0MVE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_448285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685787.1">
        <property type="nucleotide sequence ID" value="XM_062825896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVE0"/>
    <dbReference type="GeneID" id="87863050"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="2">
        <location>
            <begin position="82"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="829" mass="91794" checksum="835A0BB8516C9DAF" modified="2024-05-29" version="1">MMSAQLQQQQQKQQQDQQQQQQQKQQNQQQQQQLHQSLPSRTGSGPVSANASTAPGATRSQTPGAPATSNTQQPASFGQLRNRAAESQSPYVRLHAKTPVAWQLLNADTLKRAQAENKPIFMHIGFLADHHCRLTTQDSFSNNAVAAFLNSSFIPVIIDREERPDLDTIYQNYSEAVNATGGWPFNLFLTPDLYPIFGGTYWPGPGTEHSLAAARGGAGGVGGGAATLEASSINGGGEESYNDFLAIAKKIHKFWVEQEERCRREAFEMLHKLQDFAQEGTFSGTPAEPVPVVAPVAAADVEAGADLDLDQLDEALDRIFNMFDPVDCGFGTPKFPNPARLSFLLRLPQFPREVRDVVGDKEVENAASMARSTLRRIRDGGLRDHVGAGFMRFSVTSDWSMPHFEKMVGENALLLGVYLDAWLGRVESSAAEARLSLEDEFADVVIDLADYLTSPLIQSSGGGFVTSEAADSFYRKGDRHMREGAYYLWTRREFDDVVGPAGSAEVAAAYWNVLEDGNIPRDQDPHDEFINQNVLCSVWGRDIQALSKQFGIPVNDVKKMIATARERLRARREQERPRPARDEKVVVGVNGMVISALARTAAVVSGLDKTKSQRYLEAARQAATFIKENLWVQDGTQTRKVLKRFWFNQPSDTRAFADDYAFLVEGLLDLYEATLEVKWLVWAKELQDVQSELFYDTPAVGSTPSLRHSYTGGFYSTEEATLSHTILRLKSGMDKSQPSTNAVSASNLFRLGTILDEKPFIRQAIETINAFEAEILQYPWLFVSLLAGVVTLRLGVRETRVKVEQTASLRQYWKAPKAGASALLLGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVE5</accession>
    <name>A0AAE0MVE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_448348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685802.1">
        <property type="nucleotide sequence ID" value="XM_062825903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVE5"/>
    <dbReference type="GeneID" id="87863057"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="393" mass="44240" checksum="BDD5AFE525D83C00" modified="2024-05-29" version="1">MSTAADVPRFKSPNPMIQSISATKRSTTGTGVKSAMSTNWLGAYGDFITKNNHQVSQIESTLRSLTYIIPGRFRDAEIASESIHSGVQLLSLYHDTLLFRASSKLSQPSLANAPSPHKRYIRFWFLKSPLYRRVAYLLQIVNYVELLIEMAAKRRGERIRWRAVIIIEAIKAFCKLLLLRITKSRPLITPVLPEREPLPEAPTDEESAFQGDDSGYASASGSPQQSSPDGEWTMPRTGMSLPTLPSPGDISSYLLSRVLTADDIKPAAKLVNQLQGSAQVAEILHILSPLAFAVAMARSKNKRKAWTPWVLGLAIELVARQLRDRSLRTTPLEKEEWSRRGWALGWWMMRGAFYENITKSMVEGVRKRMPSLIGGILEDYEYLWENYHFSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVQ8</accession>
    <name>A0AAE0MVQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_504352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685596.1">
        <property type="nucleotide sequence ID" value="XM_062827906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVQ8"/>
    <dbReference type="GeneID" id="87865060"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="844" mass="97612" checksum="27071FB5C6D737FC" modified="2024-05-29" version="1">MPARANIIAPAENPPERTEMADYYSPYRTGHVMGDWTDLYMNVRPESGDSVRMDAFAALQLITKVAYTVQMFDELQPYLDETAAKYHNFFDTMCEYLLLCHLQKVYEAMPKVASIQVLHSKILAYSMVLRDAYESLIRTRNPDSHETKPKLQKLHKILKEILEPSFLRTLCSEQEAAFLCNCSHFASGYLPHEKIEQNVCNLVVALRDDDRQDPFYTTHRYMLNDLLLQLFEQEPLMLDIIFMQRWYKLLGMSDVDVPLPSYIPREAWKDNFIPMENSHWSTRWLEEYFIAALTGLDSFRPVYIFLDGPSGFRTQTWEDNNADYFHFTEFIDKVRNIQPWHKVKDREQIEGNTAAMPVTNSIKTIVASRPEKDFHDFHLPRKVMKSGSVVTVGVEAPMLRVQDINGNDMKLICRHRFGMLEKGYSTKTPKWRQKRMEETVEEIVREANGCYQVLQDALDRHPQTKFDEDGEEAPSYLELGKLHDHDALLDRDRTDADAHLPRAFRLYSSMLSQICWVNQLSDSRNISYYLNLILAHNHSHRFTSVRLKNRPLSLLEVVLAEGNKLPLYPSTETVDRLWQNCQLTANKLNKDLYPFVVLKDMEPQHQVSPPKSSKSGKDKTEYERNDYADLLPFANRALVPIHPRFIDFLVSMPEGIELLNRDCGCTNDQFTPSEYDDKPIYKKHVQLIESSKELCHLADLVEGDDPIVHLRVVPRPVPPAPPAGAPKQCTSRTIPSTSLPETDTSASSMSWEGTSWGGSGKKEGWFPREWMEEFSRETMGPWERFWGMFTSGKSRPRELASSVVELRNPREDTSTNKRRNNTPENTSRRTEMEGRGEYDAVSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVR9</accession>
    <name>A0AAE0MVR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_546359</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684605.1">
        <property type="nucleotide sequence ID" value="XM_062829441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVR9"/>
    <dbReference type="GeneID" id="87866595"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="15">
        <location>
            <begin position="489"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3351310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112625" checksum="2B7025F0BC898D1E" modified="2024-05-29" version="1">MLRNATKGAARRAVTELSQYPKPGEKLHGFTLVRSKHVPELELTALHLQHDKTGAEHLHIARDDSNNVFSIGFKTNPPDDTGVPHILEHTTLCGSQKYPIRDPFFKMLPRTLSNFMNAFTASDHTFYPFATTNAQDFKNLMSVYLDATLHPLLNETDFTQEGWRIGPENPQALVAAEGNAKPEDRKLVFKGVVYNEMKGQMSDAAYLFWIRFQDHIFPDINNSGGDPQKITDLTYEQLKKFHADHYHPSNAKVFTYGDMPLADHLKEIGAQLDAFEKIRADVANHSPIDLSSGPREVKLYGPIDPLVDANKQFKTSVSWVLGETSNVVESFSLALISALLMDGYGSPLYKGLIESGLGTDWSPNTGYDSSGKLGIFSIGLSGVQEEDVPKVKSKVQEILRSMRDKGFERSKIDGYLHQLELGLKHKTANFGMSLLHRLKPKWFTGVDPFDSLAWNDTIAAFETELAKGGYLEGLIDKYLINDNTLSFTMAPSPTFSQELAQEEETRLSTKISEVVKAAGSEEEARAALEARELKLLAEQSKTNTEDLSCLPSVHVKDIPRQKDSVILRHDNTARVNTQWREAPTNGLTYFRAINQLENLPDELRSLIPLFTDSIMRLGTKDMTMEQLEDLIKLKTGGVSVGYHSASQPTDFTRATEGLVFSGMALDRHVPTMFDLLRKLVVETDFDSPQAAQQIRQLLQASADGVVNDIASSGHAYARRAAESGLTWDSFLKEQVSGLSQVKLVTSLASRPESDSLEDVIAKLKQIQQFALAGNLRTAITCDSGSVSDNAKALSNFVNSLPSEAVTFPSRGPPKFTRDIKAFYPLPYQVYYGALALPTVSYTASEGAPLQILSQLLTHKHLHHEIREKGGAYGGGSYARPLDGIFGFYSYRDPNPVNTLKIMRNAGQWAVDKKWTDRDLEDAKISVFQGVDAPKAVNEEGMAQFLYGITDEMKQKRREELLDVTKDQVREVAQKYVVKALDNASERVVFLGEKRDWVDKSWAVIEMDINGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVY8</accession>
    <name>A0AAE0MVY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_124467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684830.1">
        <property type="nucleotide sequence ID" value="XM_062820724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVY8"/>
    <dbReference type="GeneID" id="87857878"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="203" mass="23572" checksum="AE9B3F0CDAD2EE8B" modified="2024-05-29" version="1">MESTEMMGIKKRNLHVGGQNSDKDSRFKLAGLSSPLSHPNAHLWTWNPCLAMPCLFELRFEGSPLVFLRHLLALQKCKDFHTIHTPPHFPLIDQGLGFCASRTFYLFRRSAGWIRRDTCWSFIFTLTVVTKLREKKPTNPGISTPLSPLRTQYSYQMPQKPSRLQKRHEHHDHVTEPKRPLWFSSQASYQWLRVPSHLGCHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWJ3</accession>
    <name>A0AAE0MWJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_28421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686269.1">
        <property type="nucleotide sequence ID" value="XM_062822921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWJ3"/>
    <dbReference type="GeneID" id="87860075"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="98"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="422" mass="45720" checksum="4E1177334D6B8D68" modified="2024-05-29" version="1">MMAAWASNLRPQVTTSCLVLGAVGVSLGLSVRMLMSQNSTKKQIIIPSPRATQLPQLSKEEISSLPYPPDALPGARDVETPYGIIKVFEWGPEDGEKVLLLHGISTPCLSLGILGEALVERGYRVMLFDFFGRGYSDTPTDIPFDIRLYSTQILLALASSKLPWTGDNGFHLIGYSLGGGLAVSFAKYHSHMVRSLVLVASAGLIRSEHVSRRSRILYSEGLFPESLVRWLVRRRITPQPATTTSEAKMASEVVATTTTEQSTKKHHKNSDASGGDSFDNAVLSPHRPNSTVSSVMAWQVQHQQGFLTAFMSSIRHAPIYEQREDWIKLGQLLAARRKASSSDADESAEGAGGRLPGLLGGKVLLVLGSTDPVIVKEELIHDATSVLGEDGFEAVVLDCGHEIVMTRGKEVAGLAAGFWSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWR2</accession>
    <name>A0AAE0MWR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_8506</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685700.1">
        <property type="nucleotide sequence ID" value="XM_062831483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWR2"/>
    <dbReference type="GeneID" id="87868637"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="742"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="837"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3354322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="926" mass="100975" checksum="8BE64EF84F24734C" modified="2024-05-29" version="1">MATLSVYGSDFLTTTKKKAIEDAKKMQAVVAEECNKSGKEAPPYQLEELIGKGSFGRVYKATDNKSSAVVAVKIIDIEESDRENPRLADTYSEFMKETSALKLLSNSGAKNINLILDVLPVGQSMWLITEYCAGGSVATLMKPTAPGGLQEKWIIPILREVAEAIFWVHKEGIIHRDIKCANVLVTETGAVQLCDFGVAGIVETKFDKRSTFIGTPHWMAPELFEPTPSYSTPVDIWAFGSMVYEIASGLPPNVMSGFNIPQLGNYIKSHAPRLEGDQYSDNLKDLVAFCLVEDPAKRPTIEQVQRHPYIFNTSSEYPAASLSNLVRGYKVWEAQGGIRKSLFAPVGAQGPSDYASTALSNDEWNFSTTVDFDRMAMDSDAQAVYDVYGHNVDFEFDEEQTRRPKPKGRRRPPPPKLLALKAPLEKLFDPNTISGYDENSRAYYGLGAPPLTATAETTLVLDLPKDSDLNLRQYEPSSQAALRESLIDLDASFDGNDLSQFVDMETIKAGPRGSIDYAAFNPNPDFSKPPLSDPADMPMNINRRTQDWKFPSMAAPPASAHPEMSRFPFPWNEERSNDSQNDNFVRPPLIHHPTDPLGFQSMGYDSMPPKPPVDNRVSVGSLIDLDESLPMPTNDFTNREYTRPSTANSDAASVSGSEIGGANPFDLERHASLYQPLPVVRSSSVREPSIYVSDDSDYARVAQAPSEEQFIGTNGRGTPDYASSVNGGGSVGNGSIGGGSIGGGSIGSRTSSRAHSRADSYSYATDDDVGGYSAGEYAESDYLGGSMDPMAMGSRERNRSRRRPSGMRPDPDMHHPPRGYGMGGSMNGNNGMGSHGGGHHGHQAHGHGHGHGHSNSQGSTDMMHMPQVPEPPRVRVMQGMANREEVRDDVMRLLASFSEHLGFANAHVNTLPVRQGRRGSEVNTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX08</accession>
    <name>A0AAE0MX08_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_390595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687466.1">
        <property type="nucleotide sequence ID" value="XM_062823740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX08"/>
    <dbReference type="GeneID" id="87860894"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="242" mass="26868" checksum="35DDF6F42735B298" modified="2024-05-29" version="1" fragment="single">IHEKADMFARALVGYATMDAEAMGRDTFIERVIEGGRKKRYITLNDTGGQATRIRLDRAMYSQKAIVSRGTTCYTTENNSVVKFAWASGKRTSEVEHLTQAKKMKGLQFSKPHPFLNGGDDPSSASTSTNTPGYKRKSSSDATNNTVSRSNKKQRSDSQKVIRKLSIQPSSSTSKIKPTLSTPSEELWEDRIYSCLVISPAGRVISEFTDIKQLLESMRDAIKAHQSLFVTGNILHRDISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZU0</accession>
    <name>A0AAE0IZU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_592994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676512.1">
        <property type="nucleotide sequence ID" value="XM_062831139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZU0"/>
    <dbReference type="GeneID" id="87868293"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="594" mass="66694" checksum="83CCA74C927F45F7" modified="2024-05-29" version="1">MDRNVTNPTVATSSGSTTGPSKRFGSSLTNWKSSHPVTPPPRDYQNKQVFRKKPIDSWDFQRPCGVQPPAAEADISTVYLNAKRKLEARSPYERPRKARKRNKHQSIFSTRLSDKEDIEDSNTTNGVWYERELDRNLRQWAQEAAALNSWDDPFVDTPPPSPYSEAGESVTKSATEMEVVEDTDTDTREETHSTRKETCARLEEMEEKIARLQNSSRRMTRAQSQELARLSEEYSCLCAEFFHIPQDLSPSSALPQSIDDDMDIDAGQDTTAHHPRSESLHSSDPLAVEVPNSDNHSSLNTSFNSDSTSTSPRDPAIPLRTLQDFEGYHQYLKIEFGRTKAPVYQDAPKVHRQVREEKLFLLLANKKRRVKKYWDALSQRSGEMGSERFDAGYDTEQTTTITVGGTGTTIQVTGTKVTIPASFGRRPKTEMGNNMKSKMDNSKTGNKAQKNELRSNIPSPYLNGSSSTKIAHKPKHITITQDRNMSNNKSVVSTSENTVRRNMDPYKHLDKLAKSIENKSQHKPNNSANADKTLIDFGKGEYTTLTNGDTTITYTKEYGWPMAYVTSTSAQVVTIPASFGRGNPKTDKSVKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZW6</accession>
    <name>A0AAE0IZW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNA5</name>
        <name evidence="7" type="ORF">B0H65DRAFT_81745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZW6"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF2">
        <property type="entry name" value="KYNURENINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3334387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="482" mass="53816" checksum="1FA4F03AD5BD0AAD" modified="2024-05-29" version="1">MSDFASKVKVLRDGQKPEFPSNANTLEYAQSLDAQDELRHFRDEFVIPTRGSLKKKALDGTIPGVPTNGTTDADTPCIYFIGNSLGAQPKAVRQYLEAQLETWASIGVNGHFSSFSNSPLAPWQDMAADCAAKSATIVGAADPSEVVMMNTLTVNLHFMMASFYRPTEKRHKIILEWRPFPSDWYAFQSQTEWHGLDPEKSMVEIQPDENLYLSTEKILKTIDEHAEDAALLLLPGIQYYTGQLFDIPRITKYAQERGLVVGWDLAHCAGNVELQLHDWNVDFAVWCTYKYLNAGPGAMAGAFVHERHGKVDMSAGKPVFKPRLSGWYGADKSVRFNMDKEFQPTPGAQGFQISNPSAIDLTSLAAALSVFNKTSMKDLRSKALVLTAYTEHLLDEIVRRQPEAEEPAFNIITPRDPLQRGTQLSLLLRDGLMDKVAAALEENGVVCDKRKPNVIRVAPVPMYCRFEDVCKFMEIFEAAIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0R2</accession>
    <name>A0AAE0J0R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_76256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676711.1">
        <property type="nucleotide sequence ID" value="XM_062831377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0R2"/>
    <dbReference type="GeneID" id="87868531"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="119" mass="13038" checksum="771445664D775736" modified="2024-05-29" version="1">MENVGPDRQQGLFLGSLGQRSGCVLASPTRSLPDGKERDRSFVALGYDAGTNEVRDEHSQVGCPHKSHASHDRQKAIMNLDVFDLRDVFVENFCQQHQTGMLRPDAIANTQLFGAGVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J175</accession>
    <name>A0AAE0J175_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_332813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676966.1">
        <property type="nucleotide sequence ID" value="XM_062823526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J175"/>
    <dbReference type="GeneID" id="87860680"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3334800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823639.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
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    </dbReference>
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        </location>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="2 3">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1C8"/>
    <dbReference type="GeneID" id="87862956"/>
    <dbReference type="Proteomes" id="UP001278500">
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    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="3">SPG20 protein</fullName>
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    <organism evidence="3 4">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677386.1">
        <property type="nucleotide sequence ID" value="XM_062827419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7D2"/>
    <dbReference type="GeneID" id="87864573"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051301">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Senescence/spartin_C"/>
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        <property type="entry name" value="Spartin-like"/>
    </dbReference>
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        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Senescence"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="267"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3337935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="518" mass="54609" checksum="7D3F349E609AD4B3" modified="2024-05-29" version="1">MASSHNDPKLLYAINGVSAYHIANGKEESLTPAGPQTLSLLMVPTSSAFADPALGTENAEQDFYLHLHLPPELDLPLPATTQIYHQSPTSYLIPRWDLGPDSGAFTRIEFPSVENRKGIQEDVDTFETILAQCTAFLERAPPPTLSQRSNESSGEKGGTATSTRSKGGVTEDLPAYNPGDYRPGEAYAQGSRSNPTPGQIVLVDEDDGSVIGELAEGYQVHEDSALKPGSKDPVEITLPTTPNGKINVAPASPELFDAELHPAYKKSFLVSNASAASRFIITGSDMLAKLLQNQADNYTRRSQPAAEPMKFKPATREHIRRISHFTGNAAVLSAKTVGQIGKFAQNFGANLGGRGPRKTGTKGFGPDGQPLDNYKPGLLNKSFMAFSTVMDGVEQAGRHLLASTSEAATTVVAHKWGPEAGEISRSVGGGVKNVSLVYIDVTGVSRRAILKSVAKGMVVGRTADGGVVTVGGGDGGVLSPGEGGMNSDPMNRAGRTSPGSIRSGKQPVGMNGRSETWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7V1</accession>
    <name>A0AAE0J7V1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B0H65DRAFT_434668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062825143.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87862297"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="155"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="738" mass="80609" checksum="2386AABE96C9B5FF" modified="2024-05-29" version="1">MQRVSVLFPSWNRAKQTTPVTPRSPSALNKVFGWGGKAVVPVKTTQQPTSYDRETYWPTTLDKECDKAARILKSFCMDGFLVEEPQEQDPNTDTPPTPKSVTKKIPPRILQDAVGLAVFSCMRSGLWMSGSGGAGLITARRADGTWSPPSGIMLHTAGLGFVMGVDIYDCVLVINSVQALELFTRPKVVLGVDVDLTLGPLIDADSTDNDTRWKDLNDTVLTYIKARGKHQPVPLDGSLVSERGNENVRFYNSDVSVLDILAGNIGKEIPEMRPLFEVMKAAEGRTDYDADVMEMLAQQPAPSDAVIDAPQTSVRQSIMKNPFGIPDADDPDPFGVIGLEMAGIEIREAGTRLRPISTQFEFHPSPKSPVFARFSRDTFQSRSNRESCVSTQSTRSQATIMTDACTQTDVTSTPETSFSRANSMDGRDSKLSDKLPTVVEPELEPEEIDYTQIDMSMIQRFRPLPEEEEEEKLQPEPVANLDDKTDAETTDAKSIKDDASEHHESEKDESERDEDADDEEDESDEDFDDEAIICEVATAQPARSSIRSSQITQVIHAKAGIVTIPKRVPPPLPARSAARVSRGSRGTDYGSISEISLKSPLRNSFLSMDSRMSDTLASADASEAFVTPPAVMEEVEPASPEPVRRSVQGHQKNSSSVNTAVDLSAKRRASLETSPEVPATPRTVDLTSSAEDSEREPKTPKTDSGFVSTTTLDNEKTGVKEVNIVSAHGVETNPVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J818_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062827470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J818"/>
    <dbReference type="GeneID" id="87864624"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="74" mass="8621" checksum="A2A888CA54E1C343" modified="2024-05-29" version="1">MAKAVKDYAIEYCCDYIKAKNLLRDKIVAKVLENTQEKLMELLQNDLDWMSSEEEDDDLDLESDMEEGDRTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J821</accession>
    <name>A0AAE0J821_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_560127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678055.1">
        <property type="nucleotide sequence ID" value="XM_062830138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J821"/>
    <dbReference type="GeneID" id="87867292"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21091" checksum="49111062AC537CFE" modified="2024-05-29" version="1">MRSILALFFGVAAAIPVGQVLVPLAPSSASAPSIGSGCPAGHAWVNIDATGTTFDVSFDQHAVSVGPGSTATDTRRNCRVSINLQFPQGFTFQMSIIETRFIGYASLTEGQTGTCRAGYTFTGDSSQEVVFQKNLASPYDDNYSMLAGVSVQSWSRCGASTAILNVNSEVRIAPLTSPKKGIMTVSNPWRIVLRWQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J883</accession>
    <name>A0AAE0J883_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,2-dialkylglycine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_433136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678105.1">
        <property type="nucleotide sequence ID" value="XM_062825045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J883"/>
    <dbReference type="GeneID" id="87862199"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3338745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="527" mass="56842" checksum="C6B0365972986B4A" modified="2024-05-29" version="1">MPSLQAAIDLLPVNGSKPENGKADQRLDNACDTDNLPTNLYPSITTSNHPNLNEFASSHLINFGTTFLPDLIISASHLSLFTAPSPGSSSPYGRAITDWTSGQMSSLLGHSHPEIVSVITSHASSLDHLFSGMLSPPVLNLAKRLISVLPEGLDRAMFLSTGGESNEAAIKMAKTYTGKFEVVGLGASWHGVTAQANSVQYHAGRRVGWPLVPGGLMLPSPNAYRCHEGFRRKKTTGNGEGNGAKGGGGEEGVEENGKESQGEDEEEWEYDWEAEMLYGWRLIDQQSCGSLAAVIVEPIQSSGGMHVLPPGYLRRLKIECEKRGMLLIVDEAQTGIGRTGEMVAVNHDGVVPDILTLSKTLGNGLPLSAVITSHSIANVCAERDFLFYTTHVNDPLPAAVGDKVLEIVVRDDLVSHARRMGEMLHSGLNQLKKRYACIGDVRGRGLMAGVEIVEDRRKGKEPGMELAKRIGDRAYELGLWCNLSTHPSFGGSFRIAPPITISEEEVREGLAVLEEAFRGVEGTLPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8D6</accession>
    <name>A0AAE0J8D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_591198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678180.1">
        <property type="nucleotide sequence ID" value="XM_062831088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8D6"/>
    <dbReference type="GeneID" id="87868242"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="37"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="317" mass="36632" checksum="CA8AEDDDFE84C574" modified="2024-05-29" version="1">MPTTPTNSVRLPGASRTRADRGDSTAGLMTPTTATTFHLFPCLPWEIRSRIWELTVEPRTVEVRISYVWQKISAKAEAKYRYGRLGILALRSSTPVPAPLQTCREARNHLTSVTKKGHRYYQQAFSKLPAARWFFEEIKCEKPEDRLELGLEAEPRYIWVDFDVDMISIGRSPFQFFESYYSDIKRLKFARDNSCQYFNEYESQTIREFVNAEEIHVVCLGPYGTRVWEGAHEDHCFPCDKDKLWLIDPKDGRTVKAADNDVISRETRWAGHRANGAFINPDTMEPFVPFLPPGWFEGREEWDNIYIIGTTITGMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8S4</accession>
    <name>A0AAE0J8S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">B0H65DRAFT_290178</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="31">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="31">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678460.1">
        <property type="nucleotide sequence ID" value="XM_062822998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8S4"/>
    <dbReference type="GeneID" id="87860152"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="57"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="171"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="278"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KAK3339100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="433" mass="47246" checksum="EE33CD9BC2550981" modified="2024-05-29" version="1">MKSFTRVLRPAVRRAQAVSAPRLSRTPVVQCARTLSTTSPRRDITDLPPTPITHFSEVETAMAETVQKFANDVILSKVRDMDEAEAMDPSIVEQLFEQGIMGVEIPEEYGGAGMNFTAAIVGIEELARVDPSVSVMVDVHNTLVNTAVIRWGSEALKKKYLPKLATNTVGSFCLSEPVSGSDAFALATRAVETEHGYKINGSKMWITNSMEADFFIVFANIDPSKGYRGITAFIVEKGMKGFSIAKKEKKLGIKASSTCVLNFDDVEVPKENLLGKVGEGYKYAIGILNEGRIGIGAQMTGLALGAWENAVKYVWNDRKQFGQLVGEFQGMQHQIAQSYTEIAAARALVYNAARKKEAGEDFVMDAAMAKLYASQVAGRVSGLAVEWMGGMGFVREGLAEKFFRDSKIGAIYEGTSNIQLNTIAKTLQKQYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J907</accession>
    <name>A0AAE0J907_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_579762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678256.1">
        <property type="nucleotide sequence ID" value="XM_062830778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J907"/>
    <dbReference type="GeneID" id="87867932"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="536" mass="58527" checksum="692FA7F0126A69B8" modified="2024-05-29" version="1">MGGENGPGSSPRPLTAYDPEPFEPGTAEFVKLKDDEYDAYLKARHQLDEVQRQAQRIFQGFSFRFSDSNAPFGVRWEETVEQLRVYKKRHEDIFDELATLLGSPLRAQVLVAPRHVFMPPLYPYYELVDWQNNWKIQITPVCDHPWYDAWKANPDMVLDSAESADSLPPNSLPERDPYRVPRTRENPWGDPMFEVDVPTRHQPNIGRGNRHVEPAASTATEATTNAPGPSAPDPTVKTTASSSTTGPTVPPVAAGSSASKTRQTTKVTAPAQTARSLRAQTRVGQRAVTPAVDGAGPSTRSRSRSSSPDPFIRRPKRYTAKEKGKGKATDAVEDNTAAAAAAASSTKASGFGSGSGAVSPKKDKGKGKARVTSPGPPSSSCATANKVIKSSSFKPAAAAQRATIKRSQVKKGKYWAFKAEQHLLAAAGLDDSDSDDSDDSDDSDSGEAKNKNDKFFVLACPAPELLGVCQADTPNFNRHPFKRNRAVEHFRKCGVEAEGEEDIFARFAREVVQDTARWPVNEEWARKHNQGLIGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J921</accession>
    <name>A0AAE0J921_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_445525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678687.1">
        <property type="nucleotide sequence ID" value="XM_062825751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J921"/>
    <dbReference type="GeneID" id="87862905"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="158" mass="17354" checksum="9F2676CAE5AFE5B1" modified="2024-05-29" version="1">MSRVAAFSGISVSVGGRSHQDQHREVSMAVYLVNVPGRHLVEVYTAAMLGPHVDFVRHNPRQGAVINQACPRTEGTRLSGTGVPEKVQQQQQQATTFDNPTSAHDFHLEVQLILYGLPQSSDNSWCWSGASHLPQNEMLASSQVEFSMFSTPNLVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9A5</accession>
    <name>A0AAE0J9A5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">3-ketoacyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_433180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678052.1">
        <property type="nucleotide sequence ID" value="XM_062825047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9A5"/>
    <dbReference type="GeneID" id="87862201"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3338692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="415" mass="43836" checksum="C11F0F9B464EA899" modified="2024-05-29" version="1">MAVERLGSILKHLTPGSALSNITAKNPDDIVITLAIRTPLTKAKKGGFKDTSLEYLAYATLKEVRERSKIDPALVEDIAMGNVSDGKAAYKLRAAALAAGFPNTAGAYSLNRFCSSGLKAVADIAHSISCGSIEVGIALGAESMSVGGDALEQPFDEAVTSQSQESADCMQPMGWTSENVSRDFGITREEMDKYAAESFQRAERAQKAGLFDDEIVPIKTRVKDANGEWKDVTLTKDEGIRPGTTAESLGKIRVAFPQWGPTTTGGNASQVTDGAAAILLMKRSTAVKLGQPILGKYVGSTVAGLAPRIMGIGPSIAIPKLLNQHGLTLNDIDVVEINEAFASMAVYCRDKLELDWTKMNPRGGAIALGHPLGATGARQIVTGLAECRKSGKKVLLTSMCIGTGMGMAGLFVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9C1</accession>
    <name>A0AAE0J9C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_433903</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678421.1">
        <property type="nucleotide sequence ID" value="XM_062825098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9C1"/>
    <dbReference type="GeneID" id="87862252"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF6">
        <property type="entry name" value="ENDOGLUCANASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041937717" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3339061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="263" mass="28551" checksum="37F6FC4FC73403E3" modified="2024-05-29" version="1">MKTFATLLASVGLVAAHGYVDNATIGGQFYQFYQPYQDPYMGTAPERISRKIPGNGPVEDLTSLAIQCNADSAPAKLHAPVAAGSTVTLRWTLWPDSHMGPVITYMARCPDSGCQNWTPSASDKVWFKVKEGGRTGTSNVWADTALMTAPANYEYTIPSCLKPGYYLVRHEIIALHAAYTYPGAQFYPGCHQLQVTGSGTKTPSSGLVSFPGAYKSTDPGITYDAYKGEFYFFQVDVIKEECLLIPYCAATTYTIPGPAVFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAG0</accession>
    <name>A0AAE0JAG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_254030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679223.1">
        <property type="nucleotide sequence ID" value="XM_062822525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAG0"/>
    <dbReference type="GeneID" id="87859679"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21323" checksum="5683E7F2A9A8F074" modified="2024-05-29" version="1">MSSNTKNLYYTVPLDDDLESQDYLQEKQAVPWFSVPVRSAAVAAPSRSSPLSALWRLPQRWWSNDDSHHHHSSNTNARGDRGFWGRWIWLVHVVLLTVSMTLFALSMCTLQQSASASAAAAVQCQCQGTAAAVAEGVDGAGASSFVPRSFYEGEETATKPAVVLPVPTVDIPESQHVDMEISVDDKTWVEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB84</accession>
    <name>A0AAE0JB84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Neurochondrin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_251003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679102.1">
        <property type="nucleotide sequence ID" value="XM_062822459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB84"/>
    <dbReference type="GeneID" id="87859613"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="677" mass="74381" checksum="9A084669DE0DCF25" modified="2024-05-29" version="1">MSDPTQQTGQPDPVQNAQTLLKAKDDTSRFVGLALLKSVLDNSEELRNNQEAVRGLWKSVPSKFLDRLIKTGSRQQSQSENNKNARDMLDLAVAIIHTFAALVPEENKRDSRFTERIPHLVACLLNCSNETTKLVLETLSTLVTTPDGARAFIALDDVTTLIEIAPSQPLVLDIFFYAWLNAMSSSVSSAEDKDLLRTKIDHTITALVSSFKGTDAVTLLDFLANLLPRLEPQVLPQNPQWLPTLNLFIRNLVSSRPTPAGRAAYTNLSAALLEVYPSVAPQLLFTDDPSGKGKGKSGPTDEKPFSYLLISILLIDIRSTAPTLLSQLNNPSYPQSSRRLSSAFNIISHYLGFLLRSLDSPESTSSIIDPDFLLKLRTSLSETFSLTLEFLRDRFDASVAGAMGLDPSARSSAAHDSASGASHLTLSWESMRGHSVDQDPLILAAIRALAIWLREDDNEQLRKEASGLGDLFIDLYRSSCQQPNPSRPNEKNGGKLDFRRPVLMAWEGLIEEPQGVESFLANGGWQALSDDLVRILQSTSSGVVDEAEAARGTEIVRILLQVAEMEKPGPREEWLDLVTQVAAWYIPEEQDEDEGDEDVEMVGKESKLVVYEFQVATLQLVTALLAGSHQGVQRRYVHSTSAVLGIARVLMGKVRKVGDGELVEALEDVLVTLGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBB8</accession>
    <name>A0AAE0JBB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_430228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679718.1">
        <property type="nucleotide sequence ID" value="XM_062824867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBB8"/>
    <dbReference type="GeneID" id="87862021"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="495" mass="53681" checksum="DB13718BD1984DE3" modified="2024-05-29" version="1">MEVELTAPNGKKWTQPLGLFINNEFVKSTNEQKLASINPTTEEEICSVYAATAEDVDAAVSAARKAFKHESWKSLSGTERGALMRKLADLVEQNAETLATIECLDNGKPYQTALTEDVPEVFNVLRYYAGYADKNFGQVIDVGPAKFAYTVKEPLGVCGQIIPWNYPLDMAAWKLGPALCCGNTIVLKLAEQTPLSVLYLAKLIKEAGFPPGVINVINGHGREAGSALVQHPQVDKIAFTGSTATGKEIMKMASLTMKNITLETGGKSPLIVFEDADLELAATWSHIGIMSNQGQICTATSRLLVHEKIYDEFVEKFKAKIQEVSVLGDPFEESTFQGPQVTKAQYERVLGYIKAGKEEGATVMLGGEPAPQNGKGFFVAPTVFGNVKPTMKIFKEEIFGPCVTITSFKSEEEALTLANDSMYGLGAALFTKDLTRAHRVAREIEAGMVWVNSSNDSDFRVPFGGVKQSGIGRELGEAGLAPYCNVKSIHVNMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBF0</accession>
    <name>A0AAE0JBF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_277014</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679902.1">
        <property type="nucleotide sequence ID" value="XM_062822827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBF0"/>
    <dbReference type="GeneID" id="87859981"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000056">
        <property type="entry name" value="CCR4-NOT core complex subunit Caf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="89"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3340960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="568" mass="60667" checksum="6BB086E7970D96BB" modified="2024-05-29" version="1">MPPPPLNRFPSGPSPYHQQFPTHGQHTASHPPQLAGNPAYLNQNAQVNPFSANSNLLGLGGGLNAGGGGFNVGGDSGLASHAARMGFQHGAQLQQQQQSQQQHQQQAQQQTAQHSQHAQHAQHQQHMQHAPQQGHGALADHVTRSQSKSRIREVWKYNLNEEMAILRDLVDKYPYIAMDTEFPGVVSRPMGGFRGKSDYHYQCLRTNVDMLKVIQIGIALFNEDGEQPPARPNSTDSMDLAGKRAANQQGPFPFAWQFNFKFSLKEDMFNQTSIESLQQAGIDFSLLERDGIDPKEFAALLIPSGLVCFEDVRWISFHGGYDFGYLTKLLICAQLPNDEVEFDQIMKLYFPSTYDVKHLMKHAIKQYNSGALTPNDPGAAEILQKFEQKSGLEHIADTLKVKRVGSAHQAGSDSLITGKVFFELRKRIFNGDIGGEHVGKVWGLGIPDFSVVASLPSLNTAAATASNNNNNSANAESSATGQQQNGAQNGTPSTPNGASVNLAGALAAAGANAAQAAVAAQAAAAASHNTNGGAAAMGNLGPMTPGGGGGVFGQFAFGNSNNSSANRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCL3</accession>
    <name>A0AAE0JCL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_549897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680502.1">
        <property type="nucleotide sequence ID" value="XM_062829696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCL3"/>
    <dbReference type="GeneID" id="87866850"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="83" mass="8851" checksum="5722F37D4917FA08" modified="2024-05-29" version="1">MARACGQQAVNAILADGTMPIESVPFSSSTSSPFLCRGALFTDNPSLLQCFTPDQKIPFEASSPSRTRGIRDSAERWGSVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCN2</accession>
    <name>A0AAE0JCN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_217433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680156.1">
        <property type="nucleotide sequence ID" value="XM_062822008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCN2"/>
    <dbReference type="GeneID" id="87859162"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3342363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="396" mass="44735" checksum="D0656CF81A6A66B5" modified="2024-05-29" version="1">MSFVFDSTSEDDSKLFKLLASASLRRDDKAPLYPTAATLETFENREDMKALRAQRRHFREELKLSADNREVKQLTAKIGDLRTVLSNLAVKQARENYFAEVDSLRARGLSTEDMPAPPPNPFRCSFGPSLPAATIIGRYLNPKDPASDTATKMVFPNSTDSGSDQTTQKRLAVSEMLFAYLNDRYGEVEGIAQEMEQPASEHKKAASTLSTCLLCLQSFTRRRNLSRHHRSVHFTATTFEPFSCPECQRQGKEEYRIERASEWSNHVERVHGFINTPVLFTKPIVKPKPMATTTKSKSAPCLRCGQLFYAGNSLSRHMNKYHRIVEPFDCPKCKGEGENIQINDLASWLTHTSDVHGCNGQTGVVIDKECLPKQGQKKRKRENIVEEAIKRSKLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCV2</accession>
    <name>A0AAE0JCV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_430291</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679927.1">
        <property type="nucleotide sequence ID" value="XM_062824872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCV2"/>
    <dbReference type="GeneID" id="87862026"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="19">
        <location>
            <begin position="66"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="269"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="345"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="476"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1179"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="819"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="946"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="978"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1013"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1029"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3340985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1250" mass="136999" checksum="4E40C85A0493D5BE" modified="2024-05-29" version="1">MANNLSPPGSSSYSSNTMTVGDGTWDFEKNSFLLPNLQGLNFETMRYNGMGNRFSTLTEYHSLILGHGVIAAITFLFIIPIAVLIARFYSRKPGYAIRYHAYLQVLTVGFSTVVFVLGFIAVGPPRNLTNPHHGIGVAIYVMILVQAFGGSLIRKITGHSFRLHLHRWMGRAIAILGIAQVPLGLTLYGSPKYCFVLYAVWMGFLLFLYFIFDYRDKDRREYYASGTRSEVTGYTDEKSESHHHGKKKWLGLAAGAGALAMLRGRKRNRDEEMALDRSPSPYRSHAPHDGETEVISSHGRHDSYHDDKYTDVSSRRNTGGGGGWMGKLAGLGAGLLAAKYLKKNHDRRDDEYSAVSTETPSRVPPRRGGPAPTESDYTDYTDFTRTDNRRNSKQNPVILPSEVESAADDRRPYRPGTPPRSHAGRRNSRFESTIASDYSSYVSPSRREEPEKKRNSGAGKGLFAGLGLGWFAKKTVDRRAGKEEDRIRDEEDRRYEEEERRAGRRNSKYTGDGYPSPSRRDSQRRPAAMRPAAPTDITSTTGTSLLSDEFSSMEPRGHAPYDPATVSGGARPPPAPIPVAGGAGAPPTIIPITPGPSGNPAPGNGPIGMPPMPPDPRGVFYPLRPPTDTSSSDLTDVNADRRRREAEAAAAAAAASASLLAAQQQEDDRRRKGGPSDQPVTSVKVKLQSDRDRNITLRRMTDEDARKDNGNNRRRRGDSVSSSHSESEPSSGRRYRRSDRRESRSSSQRGRAERAAEARVDPSVNPLYPAPLNTGGSGTPRQQASHGGSSGLPPDFDDPLGKDSPPYAGPSGQMPNAAGTISSLDSPGQWSALSPSGASQNPSGVASQNPSGVKREVSSAAERRQRRRFERREGSRQRAAAESSLGGSLYLITRDALPPSSTPLHQDNSHQPHYAIIDTGQRSNRDAIKSAQQYRRESNMSTDQTQQPEAMPSSSAQPQSQSQSQPQGQAQETNGHGQSQTQQQEPQSTTNQTQNQQQQQQQQQQQQQQQQPADPPSEPSSQPAPPPSSDQAQNQQPQQQPEQQEITPGPRATRLQQLFSTTLRHTLDKISRDNFAACYPTIAARAPGTLEFVQRQMVERLGVQCDKEFNSILQARQVVPKLNELETLVGEANKRKREAGGGDDATPPVPPHTLPPPVILSAHLTPHLTTTHSSLTTTLQQTQSENHQLFQEIQAQRAEIEELLAVVEKALKDVEGANELLEGVVEKGLVEEIRGVDEKVKNVGVEGVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDB4</accession>
    <name>A0AAE0JDB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 43 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_239705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680877.1">
        <property type="nucleotide sequence ID" value="XM_062822301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDB4"/>
    <dbReference type="GeneID" id="87859455"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF8">
        <property type="entry name" value="ARABINOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042099566" description="Glycoside hydrolase family 43 protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38868" checksum="6E2D3D054BE9667E" modified="2024-05-29" version="1">MRLLSLILLVSTWAWACSALVIDTVSLGLAENQLAQRTDPSLAGYLGVFFLGADPYVYFYLSNGNNPISFKALNKGSPIFKPTKGTRGVRDPTIVPGGGNEAEKKKWYIIGTDLNIGKTTWDAAQRKGSKGIFVWESTDLVNWVNERLVVVEDNTAGMVWAPEAIWDPAKGQYLVHWASKFYSTSDPNHTGTPSSIKIRYAYTSDFKTFSTPQTYIDRSPTNIIDLTILPLNPLNSSSQSYLRFMKDESLKTVFVETSTTGLFGTWTRAGGSSAIIQSGVEGPAAYWDNTVPGKCHLLLDFYGSDGYRPYESSNPGNNGGWTASGRGAWPSGLRHGSVLAVDQSLYQRLNSKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEF8</accession>
    <name>A0AAE0JEF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_187379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681464.1">
        <property type="nucleotide sequence ID" value="XM_062821592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEF8"/>
    <dbReference type="GeneID" id="87858746"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000002">
        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3344851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="516" mass="56711" checksum="A99B86C04E23C8E4" modified="2024-05-29" version="1">MTGTEATEKPNGKEAGTKDNKSGSDTKAKDHHPTPADDVQKAPKKRRKVNHACLYCRRSHMTCDLERPCTRCIKRNIGHLCHDEPRDTESRKAKSALATSTVLDSESQSDIGRSALDKTMRPPGFDGGMGNGSVQVANAAAVGRGAPLQLVQPASVAGIQANALGGSMNQFAGLPDSWLTTQNHYHDMHNFHPNYMVAPEVTNEFNLLNEFLSAGLLEESAFMSDDHGLILGANQSAVSGLSNANNNANDASSNNKGNSSSNSGMLPPSATQGTSMLPPSSDQATAIGKPASTNLKDARDAYYLQAADPSGNDTPEERMQRLLRAKYEAGLLKPFNYILGYKRLSDYLDGHVSPTSKQKILKQIDRFRPKFREKIQILTDMDLVMVEMWFERTLLEYDRVFASMAVPACCWRRTGQIFRGNKEMAELIGVPVESLRGGQIALHEILTEESNVRYWEEFGTIAFDPAHDTLITACSLKNPNDDKGTKVVNCCFSFRIRRDDHKIPSLIVGNFLPHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEP5</accession>
    <name>A0AAE0JEP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fluconazole resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_573614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681600.1">
        <property type="nucleotide sequence ID" value="XM_062830552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEP5"/>
    <dbReference type="GeneID" id="87867706"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="150"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3344987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="625" mass="68688" checksum="F5156FCF4A7AFC3F" modified="2024-05-29" version="1">MTLTEADREIAAAEIDASPKEFAGQESLARRSDEVERVMSASSVSTTSFEERQRRARRVSGVSTQHDLERHPTELSRIQTQRSQHTNTVGRSGTRGSRTSRRSEKPLPPFGAGKPYPPQLPDPDEYVVEFDGPDDPMHAMNWPFKKKFWTAAMLGYTSLVAAFGSSIFSSATSTIAKIYHVNLTVGILGVSFYVLGFAFGPTLWAPLSELKGRKLPLVIGMFGMAIFSIATATAKDLQTILITRFFGGFFGACPLAVVAAVFSDMFDNRTRGIAITLFSMTVFTGPMMAPFIGGFITTSYLGWRWTEYIVSFMAFLAFGLDLLFMNETYPPQILVKKASELRRRTLNWGIHAKQEEIEIDFKELVSKNFSRPMRLLFGEPIVALLSIYMAFIYGILYLFLTAYPIVFQGVYHMTPGVSGLTFFGMITGQILAGISILLQQPWYMRKLNANNGVPIPEWRLPSVIAGGVAFSAGLFWFGWSGYSGHVHWIVPTLSGILSGFGLASIFLQALNYLVDSYLMFAASAIAGNTFLRSLAGAGFPLFSTYMFKGMGIQWASTLLGCVAAALVPIPIIFLYYGHRIRAKSAYAPKFAPGGPAVEDESGDESEKEQPSGVPRKDGDAATNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEP8</accession>
    <name>A0AAE0JEP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Translation initiation factor eIF2B subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_463977</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681241.1">
        <property type="nucleotide sequence ID" value="XM_062826740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEP8"/>
    <dbReference type="GeneID" id="87863894"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="14">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="15">
        <location>
            <begin position="445"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="305"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="536"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="548"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3344628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="582" mass="62811" checksum="75687B9E0E3ED2D7" modified="2024-05-29" version="1">MPHAVTIATPGLQALILCGPGSSFPTFTANPDANPKALLPIANRPMVWYPLDFCYRAGITNITLICPPTAQEAIQTALNTNPFLTSLPYPRPDLLAPKDLDQNTGTAEILRLPEVQATVTDDFLVLPCDLVCELGADKLLQAWMVKSASLTDLLDDTRAENGPLKRSGGLGVWYQTKTATPIKGEETDFLATVPLPSSSVSPPKGSLFPNISKVAYSMPTDSLKDLLEEQKGFPTRHALLKKHPRVRMLTTHRDAHIYIFPHWIMDFVKENDRLETIGEDVLGWWAKAGWQKGLSTKLGLDTILGQSSTTAPNTDGKTSPVGSHTPKDSATVHPPTGSQIHDAVSASGATNLEGPVRPVIRAGDKPGQANEQNDSTIPPMLAYVHPSSSTGSTPLIRRVDTAQLLLQISLQLAKLPSIEEVGSAEAASPFAHMRKVAYPEGVKPRTTITKQDSLVADNVTVQEKTSIKECVIGANCQIGEGAKLSQCLLMDGVVVGKNCKLTKCILGKRSEVGEGCTLTECEVQENLLVEARTETKNEKFMSSSGLEATEEDLAEDDDDEDNDGNGNDDDDEDEEDDESAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JES7</accession>
    <name>A0AAE0JES7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_464273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681343.1">
        <property type="nucleotide sequence ID" value="XM_062826752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JES7"/>
    <dbReference type="GeneID" id="87863906"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041942427" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8356" checksum="E8D38DF93B7BB408" modified="2024-05-29" version="1">MNGTRASFHWTVFALFPAGLAGLARTLMSPALQLSPGVDQGMRKTTLEKRVLKPSPCLGILGTRWIRSTHAYPVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JES8</accession>
    <name>A0AAE0JES8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_181817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681266.1">
        <property type="nucleotide sequence ID" value="XM_062821519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JES8"/>
    <dbReference type="GeneID" id="87858673"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="3-oxoacyl-acyl carrier protein reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3344653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="32488" checksum="7AF0DA744C80247A" modified="2024-05-29" version="1">MRTLLHKHALITGGGSGIGLAIARRLHIEGCSVTLLGRTESTLRHAQSLLLSQSSQPTPSSPASSTSTSSSPSPSKTQPDASTPPPDGDKRVSYHPLNVTSAESWEGLLKSCGRVDILINCAGITQRSPLMKTAVEEVEELVGTNLTGTVLGCKFVGRAMLRNRNRSSTSKPKAEGPTEAVQEGSKGEAQEVQEGVQEGVAERGVIVNVASLLAQKGVVGTSVYAAAKAGVVGLTTSLANEYGRSGIRVNAVLPGYVETDMTTGLKNPSILQQIPLGRFGTTDEVADAALFLIKNPYANNCVLNLDGGLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF10</accession>
    <name>A0AAE0JF10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_442274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681401.1">
        <property type="nucleotide sequence ID" value="XM_062825570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF10"/>
    <dbReference type="GeneID" id="87862724"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116662" checksum="22F90FAB553B37DF" modified="2024-05-29" version="1">MSLTLNISEEERACILAGFSDPAVRANSKLSGQSHRSDKDDEAPATLPARVLGRARLSDVVRSAFDPGERSDDEDYQRPLPKHAESIQNLANALAEVMVPDISAEVPFVHNPHRTPKETSRGDAFNSIRQLDAKNLAMRLMKEPSAHNWMRYITFTPGGCEFTASDLPTIDELVDTATKFKYWANSRIRLLKEKESLKALLDDLIDALWNNRQDRFRFAGTCGEVTAELCSDAVVGGIDSLMVFGMKVFLHESGWMYKIASLPIKFLESLNIRPHRQTSLYQTLVNCERLLVRNSYLTSTMKAKLEIPKEEWHQLILDRTPKSDLQQKAFSETPLAHLFYRQPFLSASSDTHINHEESSPGVNAPKTSSPRTIDILAMIMVSDREGDLPLEDLTDDDDDKPHKSWRDSAVQCIRGKSVENVASLLNSRRAWIKWIEDGQNDKVHIFTSADLPPIGEDSPDNKAVAAGSDTMRSLAKKMAHIARHYLPNELRLTNDGDGFKYERLFLSLEKAVTQCSDMATYVRTKTKVFKREVPRRVPSIAILFKILTIASDLPQLSFHSNAPRHLAMSSPPPKPYEVVDKLLSERAKNTKSKETIKWLLERKTFLSSIFEADDDKYDDEAFEKALLEAMIVDRDNLPDQQVLNGDREDEWKLALERIKGMKEDEMKSRLEDLFYTLPTRKDIVDFMSPLGAHEAVAEESVIGAMQLLFRNYVAMSLLIESKIKSLMKPQIWLDIPFEELDKVLKDRLPKDVGDKLIEVTRNNQLSAKPSTYLPDNGTLTDAKTFAKVLAKVMLADKFGELKLPVYESSDLVVARMNKIKNSSLTPELQGPVGFRGEIEKMQLQEAEYAILDLDEETIVSRLVDERWMQCINDRAGFVSHDLLSPDIKFLRHKIARKPVPSVTSAEAGESKTKESTVTESGTEQSAAKKSKAEQPDAVKSDAEEPKAGESAVGETATGESNGEQSNTGESSTGSPGTGESSTEQPKPQEPTAEAPTAEASKTEQAKPGDSGTPPVTTKKYTEYGDYCDEWNVEEAFRGELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF29</accession>
    <name>A0AAE0JF29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_186579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681431.1">
        <property type="nucleotide sequence ID" value="XM_062821580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF29"/>
    <dbReference type="GeneID" id="87858734"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="258" mass="28681" checksum="2741D95CA781CD02" modified="2024-05-29" version="1">MSRTFPSGPNLCHLCCLAQGSAQCEQCPVGRLQPIAVGSSQPEWLGGLAVPTNGIIPILGIEFSFTVRYCWLSRSLIGEKRTKLREPQAKQNAPGTLKSTFAMWLALTDERACFVRHQFPSGKLSQPTQCTMYTEAAYEEAGALVLLPDPCSVPWCRSIPVGQRKSDTSLYVQFTHPHRNVFFGRISGPTLTFYCPPACHTPSTTHAFLIPELSLPEFWPEHPLLITYNGLCLRCLLPFIDNLLHTRPSTCPCAPFWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFM7</accession>
    <name>A0AAE0JFM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_185539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681397.1">
        <property type="nucleotide sequence ID" value="XM_062821566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFM7"/>
    <dbReference type="GeneID" id="87858720"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3344784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="922" mass="103298" checksum="E28114274DC5BA04" modified="2024-05-29" version="1">MSEPSRGSIEPNSVERSVERSHSPAAGHKRDGVSRDRDESHDPDDDHHDGNGSRPPPRKRQRVRLSCLECRRRKLSCDREFPCSRCMQSGTPERCEYETRPGLAPPNKLGLSHSALAGFDSRLSLPNGGSGDSSYYRKDARESERIRRLELEIAQLKNIVLKQHGSLDGSTVTDNSPPVQKLHTAPDENLEIGAPFGYHNQFADAVNDESKEELRFLRGKEFKTRYFGPHSASRAFSELAGLCHFMKETSEEFFRPFAIPNTKDRRRRAEEREIRFHQADTSLESLLPSKERTDSLVTIYLDQFEQIHRIVHIPTFRRDYDKFWDPAQTRCASFTALILAILGVSSCLGSHFPQEFDKMISRSHADALKWIDAVDEWQQKQSQKHRRLIHYQIACLVYLAKRVNTVKKKRFWKGAGAMSMDAISVGLHLEPSHNITPFNQELRRRIWATIQSFDLQASFDMGLPSILGALHFNVEPPRNIDDDEFDENSKELPPSKPPTEYTFSSYQHLSRQSLDLRLELIRVLNGPSEKLDYDQIIRYTNEINQEIDSLPSWDVTEADAPTGVLKKPLLAYTLLHIQLRQFIIKLHHPYLKLRKDNSKYQYSEIIYYNAARDMVLLNDKLAQQGIRTLNYLREDCLTLAINLCSVTMLQPRGSTNMIMINSQHTLQLLEKCLSIKEDRILCCGNNEPWGYSIMCAAVGLLEAHLGVKTTEQAKATSAERFIKLHCKLVPMAPGGPGGSNESQPSSSQERGQQTPAGQRGHQCGAEKQADAERPPQQPGQAGDRGSVTPVNGQPSGVSGVGNNKVAPNGLATPSNSQFLNGIAADFMAQRLRPPTPFLQPGNTQQQQPPQAPMPPASLGPAAVDIPGTPWSVVPGVGLTGSGGEWSTAGGFQFPNTMNSEFDINQLGASMGELWPSDLWDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGM6</accession>
    <name>A0AAE0JGM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_549299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682231.1">
        <property type="nucleotide sequence ID" value="XM_062829650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGM6"/>
    <dbReference type="GeneID" id="87866804"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="296" mass="32575" checksum="C5839DF70C8765B1" modified="2024-05-29" version="1">MLNLNRQPSTSDEHGSAHNLQPGGGSRPGQHADSNITQGQLALVGYSSSAPRPASNVNFDIPQAAPLMTSDLQHQQTALLQYPSQVEQDTSAMLGMPIMSYPTTNTGIGNLPAREGVPSVYTQGYGGPVPSISYPNPTAGQGGWYYGQQVPPAQPGVYQNDGSHRPNPRGAAPSERDWSEEHTWILREGKRLGMKVHEITHWLSLIDGIERTPNCITKRWARIKQKCVPKEEKDEIVRDLTPTLTQLIYDAVCNKLGGQRLNDAGQLTDVERDVKEITRQHMERCIQEVLVRALGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGP1</accession>
    <name>A0AAE0JGP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_460790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682650.1">
        <property type="nucleotide sequence ID" value="XM_062826559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGP1"/>
    <dbReference type="GeneID" id="87863713"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="287"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="876"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="946"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1250"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1262"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3347568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1275" mass="145495" checksum="BCADF603BCD1B1BA" modified="2024-05-29" version="1">MPPRLDSFQRALDRFKKSLDPKHAQAFLASTREDVFLEMEKIQDEQGRNRELRGLERLEPFLEAMTQLGKVIEVFTNTTVFLCFVWGPIKFLLATAKTHLESLNKLLDAYEEIALIFPGILHYQATFEQYQPLDNVLENLYSDILVFHEKALKVFSRPKWKMLFNAAWKTFESDFGQILHSLRERRKLLDSEKGSAALYEIQLMNKKIGHLQEDQIENEEAARRERHARRIESINRRLGPPKYQTDHLSFINSRDIPINRLKRSPGEWFFADLRYQAWQNSNARESQLLYIHGAPGSGKSTLMAATIEQVLGNNMPDVAIAFFFFRHLQEDKNNLNGLLRAILAQLLDRYPDLATTLEEEISKKDTIKLQKTDELEGLVSKAIEAFQTVFLVLDGLDECADGEAEKTIDWLVSFGNGSIGCKLRILCAGQRDGVSDRRLLSLLSTVSLSLDEEIKHQEDITSYCQAWGKRIQSQFEAEHGLEQDIVARVSAGAKGMFLYAKLVLQHLFHQDSIAALEEQLEPGVFPNTLEKAYEKVEHRVFTNSPPSKREAATKILSYVVCCRRTLCWREIQAFFCTDVTKREANYKRRLAWSYKELCSSFLDSDTIRDNYAGPEDEVRLVHKTAREFLIRRRRLDIAQQTAELSVFCFQYLTSPPFTLGISEEDVLSYAKKGYYALQDYTVHYWFEHLLECVKSLDPMTNVDKCQDIFDLALIFLRSYGNREKMAEFLRAETYTGLTDAITKHLPTHGRERNAYLCIEIRTESLRQKIAKLDFGAFTAEEQRVFDNLHGPRTSYKCSKPWCDFFKGGLVSEANRQKHIDEHEFPHRCAYEDCIGFKLGFSTNGELQKHNGKWHARQNDANSFPKLEASSSLSGDSNESSLHEACRRGDIGRVRQLLESDAGKNAINIYRWSTESKVGFPLSIAAAMGCKEICDLLISNGAFVDIDEGAPLRAAAENGHLEVCELLISHGAIVDKGSGAPLREAAKMGHLEVCKLLIQSGADINFLWNGRTPLHEAAEAGHVEIIDLLLHQADIEPNKGAHNEGRTAAEAAAAEGQIEALHCMRASGKVDMSVGLLRSACTYSSGSLDTIKYLLNNGHVDEADERCVWTVLTTVSKEATRKYLANVGLAIGMLFSTGNPVFSDVERLTTELGYKIKKIMDYNKSAFEKRWYLYEKEIKDQKRMMEKRTPFLISIMEYLKWRIKRSDWSRFLENRKEFGMELDTELGEAVNKFVKRIEGNRSTTIVEDQPEVEGKAEPMETAIETDEEMDEEDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGV0</accession>
    <name>A0AAE0JGV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_570694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682725.1">
        <property type="nucleotide sequence ID" value="XM_062830458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGV0"/>
    <dbReference type="GeneID" id="87867612"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="132" mass="14456" checksum="2ECD927D3EB2E2B0" modified="2024-05-29" version="1">MPAMNRIGYAVGVIGLAALQGIYTVAERDLAKAGTNELAEKLHHRELLCGDILCAVLELEQNAKHVAVNEDVVIDTDDTVHKDVAVVVDNSLIVDEYNTDHEFVCINESDAEMSQADSAEWELVSEVSDYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH55</accession>
    <name>A0AAE0JH55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_490745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682648.1">
        <property type="nucleotide sequence ID" value="XM_062827734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH55"/>
    <dbReference type="GeneID" id="87864888"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="277" mass="32228" checksum="7C7F8E076D3DBA03" modified="2024-05-29" version="1" fragment="single">MRLLERDDTGGVRLTKVPDNKIPPYAILSHTWGPEEVLFKDMTDGTGKNKASYAKIRFCGDQAWRDGLKFFWVDTCCIDKSDSAELQYALNSMFHWYRSAVKCYVYLADVSTHQHGDGPGWQPAFRKSRWFSRGWTLQELIAPTIVEFFSKEGERLGDKESLEHEIHDITGIPRKAFQGVPLSDFSVAERMRWIEKRDTQYEEDKVYSLFGIFDVHIPVLYGEGRQKALKRLQDKVYEDYLCLAKLWPTDSRDPHVEKERIELAKGGLLADAYRWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI12</accession>
    <name>A0AAE0JI12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3176 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_422535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683249.1">
        <property type="nucleotide sequence ID" value="XM_062824407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI12"/>
    <dbReference type="GeneID" id="87861561"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="77082" checksum="A7C290F3EB72F3F3" modified="2024-05-29" version="1">MIPGNNINQEHEPSDSTPLSPQSPIQDHLPLGQHEAHQDCIIPQKVIPRRILQSNTRLSQYSPWQRWGSSWFWELAAMTLSCLSLVLTLGILYFFDGKPLESWPLYLSLSTIISTLAQISRTSLAFAITPCLGQAKWNWFSQREDDVLVFRTFDEASRGPLGSLQLLWKLKYRHLACLGALVTVVMFGYDPFVQAIVDTSGDDFLLTGSSRAKIRASNRICVGEEQTTGTQITLTNKNGSMGPGTVVLQESALTADFGLTLAVYDGFVNKSSALTDPYQSSFSCETGNCTFQIFDSLAVCSRCVNVSDHIRRQQVPKEGTTYTRYALPYDLEILNWDGAKQPENAYPILYGDTDQPSAVASSSPNQTVVKVIANRSESISFDYFTSTFVVFRIIQSTPEFVNNLSPWNTTFPLAMECGLSFCVNRYESMVSKGILHESILDSWAEWSHPSLLPQDDTLGGNITAKKQRENWMHPFSYTLGSPVGRKPNGMLWDFPRSDLLLASRATAVSNHLSYFNITQVTIASTIDWFTHVLAPEPLMYPVTADTGNGNPVAGAIAKSTNLSTTFDNVAWSMTAWIRENEGVWVTESSTTKWVFRFRIRWPFVTVPVAVMVASALYLGLTIWQTRRNCVEPWKEDALAAIAHGLDQESRAKICQAERVGLRNEAAMGMKVRLRQGMYGEVELRDVRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIR8</accession>
    <name>A0AAE0JIR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_169309</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683296.1">
        <property type="nucleotide sequence ID" value="XM_062821345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIR8"/>
    <dbReference type="GeneID" id="87858499"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF208">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041941265" description="alpha-amylase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="35"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="51"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="262"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3348214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="534" mass="58551" checksum="35CEABFE7C4364C4" modified="2024-05-29" version="1">MRSSLLTGAIAAALSFSGYAAAADAEAWKSRSIYQVMIDRFARDDGGSVDCKLYEFCGGTWKGLLNKLDYIQGMGFDAIQISPVIKNEDKDTAVGQPYHGYWSQDLTQVNPKFGTEQDLKNLVDEMHKRDMFLMVDVVVNHMAQEFDNIVPPKVDYSLFNPFNDKKYFHPYCNVTEWDNATNYQDCWLYPYGIALADLKTESPDVVSLFTKWIKNLVSTYSIDGLRIDAAKHVNDAFLPAFVEASGVFALGEVLTGVTADMCRYQNKTKSLLPGMPNYLDYYPLNAAFNGGDFTTLGQIRSQAQDQCNDTLALGTFIENHDMPRFASQNDDMALAKNAMTYVIMNDGIPTVYQGQEQHFKGGATPDNREPLWTSNYNTSAPLYQLAQILNKVRKNAIKVSPDYVKQTSNVLIADVNHFCQSKGPAENSVVFCVTNKSSKGDSYELPVPGGFRDSDQVVEVLSCATTTADGLGQITAFMGAGEPKVWVKQSALEGTDICPKTTVAGPIKENGAVSKGAATGVLMAAVLGTASLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIU4</accession>
    <name>A0AAE0JIU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_424915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683654.1">
        <property type="nucleotide sequence ID" value="XM_062824540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIU4"/>
    <dbReference type="GeneID" id="87861694"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="323" mass="36208" checksum="6066A82E51649E63" modified="2024-05-29" version="1">METSTEATPQPSESYEELESPYLPPHVSLSPEVDRLVWEFKGTFPSAISVMSNDSGAEGHLEPFFKPADATDDQNPENTSTGTYHPIALLPMTDPPASLMTVASVDLDSWEQNWVESHEWHSEVHGEFVTYGDLDDDIRPWLDDPKEEDPYNWEADSDTEFLIKCCGEDRPVRTWGRRLKVTPRGAGGFVTIGDYVCAVHTWLMSMRDDVLKARGVRQYDQCDASHPEFEWMVTFYDDEPAHWLVEKTEWVRNHCPLSQDSIDAANAMLRSLGSSGDVVNVVNVPVGGMGIRINPGGEGQEETTEGQEERETELEGKGKKIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ68</accession>
    <name>A0AAE0JJ68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_455544</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683970.1">
        <property type="nucleotide sequence ID" value="XM_062826242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ68"/>
    <dbReference type="GeneID" id="87863396"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="106"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3350675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="505" mass="55246" checksum="EC01D46FA601216A" modified="2024-05-29" version="1">MSNIAPSVLRQASRLAAAAPLRSARVLSRATTAAAVKTASASRSYVTETKRNNADVQAEHAIKLDHREMEKQGLAISAQNGSSQHVSPMADVLSNATVMDEGQRPIYLDMQATTPIDPRVLDAMMPYFTNVYGNPHSRTHAYGWETDKAVEEARKHIADLIGADPKEIIFTSGATESNNMSIKGVARFFGRSGKKKHIITSQTEHKCVLDSCRHLQDEGFEVTYLPVKSSGLIDMAELEAAIRPDTAIVSIMAVNNEIGVIQPLEEIGQLCRSKKIFFHTDAAQAVGKIPIDVNAMNIDLMSISSHKIYGPMGIGAAYIRRRPRVRLEPIISGGGQERGLRSGTLAPPLVVGFGEACRIAKEEMPYDSKRIKYLSDRLLNGLLSMEHTSQNGDSNHFYPGCVNVSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGNSDESAHSSIRFGIGRFTTEQEIDYVLKAVTERVGFLRELSPLWELVQEGIDLNTIQWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ90</accession>
    <name>A0AAE0JJ90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_439474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683723.1">
        <property type="nucleotide sequence ID" value="XM_062825417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ90"/>
    <dbReference type="GeneID" id="87862571"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="106" mass="12088" checksum="0C3D41D481882F9E" modified="2024-05-29" version="1">MTFSLVAFIYPKEDKVERLKEVAKDIAEWVKANEPGTLQYHWSQSTEDGKPVFVVQEIYADEAAFEAHKNGEKFNWFVETGKKEDLFAAPLKVCILDPFGGFASRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJS2</accession>
    <name>A0AAE0JJS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_104853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684250.1">
        <property type="nucleotide sequence ID" value="XM_062820474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJS2"/>
    <dbReference type="GeneID" id="87857628"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="71"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3350955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="507" mass="56313" checksum="12F49CD2CB0ADE3F" modified="2024-05-29" version="1">MLFSKSIASRAGLASAVASRSCRPTFAAMPLRAKVLGQQAPISTQAAAELFKPVEGDEPEDVLFNSLYNLRSIELNRPAKYNALNGSMIRKIAPRLLEWERSDIANVIVIKGSGEKAFCAGGDVAALAKQNAEGPEGIKKSVDYFGLEYKLNHLISTYTRPYVAFLDGVTMGGGVGLSIHAPFRIATERTLFAMPETKIGFFPDVGASFFLPRMPGQVGTYLGLTSAQLKGVQVYYAGIATHYLHSSSLPALESRLAELTPADYWTMEQRLSVINDTIEEFSTGVPYDEKIQIGGRVRLAIDRCFKHDKIDEIIAALKEEAAEGAKGGVSGWAKNTLEELTQRSPTSLHVTLRQMRLGKTWGIAHTFKREHQMAAKFMKSHDFNEGVTALLIDKPMRPAKWKPASLDEIPPGANITEDYFRNDPELPVLELLNDRSYTQYPHNKFGLPNDYDVREAIEKGNFTREKLVDHFVETRRGKQGVREAVSDILDRMAVRSKGTDNVQWKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK18</accession>
    <name>A0AAE0JK18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_109755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684480.1">
        <property type="nucleotide sequence ID" value="XM_062820557.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857711"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000072">
        <property type="entry name" value="Cysteine proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="215"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="926"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1190"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="652"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1106"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1231"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1271"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1333" mass="150059" checksum="1436834792025665" modified="2024-05-29" version="1">MSRSPSPTPGGRSVLAEMTVYQPRGGPWGQHHKYRTPQSKVDEFWTKFTARVPGKATTVLPKNEYAERLTKRNSAKEVGGGTNAQASFEEAAAICRAKVEKIVQECRRVNQKYRDPHFDLEYDLKTGRRDCLESLSNENIIDFSSSDSDSDYNHLPRPRSRSRRRRRDYGDRDQGTTQAEGQTKTKTKADKGDGVSQLSPQGRMPGSKFRPASVKRVGEIFDDPKFYIDGPTANDVRQGRDGDCWLMAALCTMSNKPGLIERICVAHDQDIGVYGFVFHRDGEWFSEIIDDKLYLTRPDYDEAMDRFHMERVLWDDRDRPDSEEIYRKTYQSNSGALYFAQCENPNETWLPLLEKAYAKAHGDYAAIEGGFTGEGIEDLTGGVTSGLYTADILDKEHFWKEELMKVNEQFLFGCSTGVWGRGYGDRKGIMEQHAYSVMKAVDIDGERLLLLKNPWGKGEWTGPWSDGSKEWTPDWLQKLGHRFGDDGAFWISYRDFLRKFQAFDRTRLFGPDWKVTSIWTTLSVPWTLEYHDTKFAFTLAKPGPVVIVLSQLDARYFRGLEGQYRFELNFRVHRAGEDDYLVRTQHSSRMNRSINVELDLDAGEYLVLVKIDATRNEWVLPTEDVVRNNARHHREKLLRIGLSYDLAHSKSKIKESSEEKAAREAHEQRKKDKQRESLRKAIMEEKEMNFYNRMKSYQRQKRRVDKNKERMKRKAEKRKAKMEKKKAKREGAERKQAEETSEDPIDGQKAGSKGRNFSLDAALHPAGEHMAPPVVDTAPSTDAGQPTPSVSSTGATEVDAADRLPEPVLSGAVGKDNKAPEVPSTGVLTPPSASTQQQDGESSARVVKPSSEQPKEASTQNPFDVQPGPSAETNKSPEDTLPEAQSRPPTQGEGGRGANHTKEIENKLRAAVNLFSSLKQELELMLEDNVNNGTDQGQEQKPKDVDNQRQPPPPPPPPQLRAPSEQRTLQPPMPPPPRPFSPPHPQDHRQQRPLSQLRGRSPMQPPIDIGPSPRRSRHRYGGPLPQRREVFIDDPHHQSRNNGPRFYDDSFSESSPSSSDTDDTYSISSISDISDRELDMHIREDARRNGRLLDQQGSRQQAILPPIQPQPGPPQPQPPMPGPPIGGRGRDPRGRHGGGGRDGPRNGPVDLNAEFEKNPWNAVAVVGLRVYYRVDDAGTGQDATAAATVTATTAEDKDAAAGGKEEETKKEMVKLKVIKPNPWEIVSDDEKDAKKKKEKEKDGEKRESKWTRGFKKSKKKGKEGGEEEEEEGKKKKDKKDGDTTEAGRKANDEGDKAGLKKEEVEKVLDVDDSAKDATLEGEEREKTVAEGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK80</accession>
    <name>A0AAE0JK80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_109766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684477.1">
        <property type="nucleotide sequence ID" value="XM_062820558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK80"/>
    <dbReference type="GeneID" id="87857712"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="244" mass="26539" checksum="343884C6360D5FF1" modified="2024-05-29" version="1">MGGRGGPGGRGDVNTYGSSHNPNPIGTFDMATMPEISKSCGPVFLLGPCSNRLRQRKTTARDPVPTTMNFRAKTGSWDILASVGFWKKGLSQLARGWLPLAGDIVLFLPDRTRIGKWNPSSCLASLAGGAKLKKAGGSAMIILLYRGAQQRTWASTWAPARRLAQTGLLSFPHPRLDPNWRHNDGNPCQPCPPAWTLAGFSGSLPSPNLPVHPKQSYSTFTLHLIFTLRSKPHFPVRPDDPNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLK4</accession>
    <name>A0AAE0JLK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cyanide hydratase</fullName>
            <shortName evidence="7">CHT</shortName>
            <ecNumber evidence="2 7">4.2.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyanide-degrading nitrilase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Formamide hydrolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_507238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>formamide = hydrogen cyanide + H2O</text>
            <dbReference type="Rhea" id="RHEA:21720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="EC" id="4.2.1.66"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer of dimers, forming left-handed helical fibers.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By cyanide.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.66" evidence="2 7"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685182.1">
        <property type="nucleotide sequence ID" value="XM_062828126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLK4"/>
    <dbReference type="GeneID" id="87865280"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030196">
        <property type="term" value="F:cyanide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019500">
        <property type="term" value="P:cyanide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03224">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037544">
        <property type="entry name" value="CN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF4">
        <property type="entry name" value="CYANIDE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="350" mass="39351" checksum="9CD0E2E4750B6848" modified="2024-05-29" version="1">MVLTKYKAAAVTSEPCWFDLEGGVRKTIDFINEAGQAGCKLVAFPEVWIPGYPYWMWKVNYQQSLPMLKKYRENSMAVDSDEFRRIRRAARDNQIYVSVGFSEIDHATLYLSQALIDPTGEVINLRRKIKPTHVEKLVYGDGAGDTFMSVTPTELGRLGQLNCWENMNPFLKSLNVSMGEQIHIAAWPVYPGKETLKYPDPATNVADPASDLVTPAYAIETGTWTLAPFQRLSAEGLKKNTPEGVEPETDPSTYNGHARIYRPDGTLVVKPDKDFDGLLFVDIDLNECHLTKALADFAGHYMRPDLIRLLVDTRRKELVTEADRNGGIAEYSTRERLGLNTPLENDKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMF3</accession>
    <name>A0AAE0JMF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_459912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685393.1">
        <property type="nucleotide sequence ID" value="XM_062826496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMF3"/>
    <dbReference type="GeneID" id="87863650"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3352098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="235" mass="26133" checksum="C2314F3A45B75ABF" modified="2024-05-29" version="1">MKSCGDDRGEGQSEGLTCLRNLSRYCANRGSVWHVTHSGWAGSRVNSFKRSDKFPTFRLHLDLPRLLDANSCSLRHPHRHKPLSLDVNCRRTFQHHVRRGAARGKDFAHRTGGLWPVTIGIGIWIGCSRRPGINSLPFSASAAAGVFRVSCILCRRPLLDAFEAADKVDVPLDVFAGFEVGVCDIEDAVSQDLVDFFEGPLEVHVTVHRGLVLRRLWLLAASSHLSFLVARSEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMK8</accession>
    <name>A0AAE0JMK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_145790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685453.1">
        <property type="nucleotide sequence ID" value="XM_062821000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMK8"/>
    <dbReference type="GeneID" id="87858154"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="10">
        <location>
            <begin position="261"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3352158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="459" mass="52434" checksum="6B66BC5C877AF19C" modified="2024-05-29" version="1">MSQSVVDSPSPTKSEKKHKKDKKRSREEAEEVPAVEDAPKKHKKSKSESLETETTEKKKKSKKSKKDDEDVEEEAPAKKEKKKSKKSKEEPMVEEEQEEEEAAVASESEAEEKKKRKSKDKKEKKDKKDKKKRQASATPELETTTADDAMDVDTTTSFPTDDVDFPFYTQVHSLYVPFYPCGFDKPLTNVAAQHLEPLLNHYSPVLRGVLLRYTNLNLSERPVQASVINPPTDETPALLRSVDEYAVGFAYLTFDAHMFKPARGKWMEGVVQLQSEGHIGVQCWGRFNASIEAKRLPKGWKWVDLKGDKSYNQQEEEEQEEEEQGEEEEDQLDGEELQVVEQVHTTGYWVDASGKKVSGKVRFRIKNFDVGLAGDYGYLSLEGTFLNDEDERALQKEERELERKRRSRQNPGGLLRPMSRRVPEFSMTKFGKEEEEEDAGQRTVFAKVTGKEGDVTPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMT8</accession>
    <name>A0AAE0JMT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_447552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685586.1">
        <property type="nucleotide sequence ID" value="XM_062825867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMT8"/>
    <dbReference type="GeneID" id="87863021"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="207" mass="23493" checksum="495CBEBE0A708455" modified="2024-05-29" version="1">MASPASEPLSQSTGRDSRRVDDARNARFPRLKMERRTWRRTLPRLTPHASEGVWRVWTTATNRIKGGERRFYATHITFSHSQATVIFPSKEPVGRSQSLSIFSLPAQVPCVSSAEWLQGLCGVMHSYPCTLRTSKCGGRFELRVVSELLKLMRVFSASGCMAWYLSPGHARARSGSETRSRRRLQPNRGRRLLGLFDTRIVAWMAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN49</accession>
    <name>A0AAE0JN49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_417982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686022.1">
        <property type="nucleotide sequence ID" value="XM_062824120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN49"/>
    <dbReference type="GeneID" id="87861274"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="87" mass="9497" checksum="ABB99C5792CE7182" modified="2024-05-29" version="1">MKYWKQHFSTGYTDVNGKLTISPSQSSLIVSILSTGTFVGALASPLLADKIGRRWGLIISSWVFNFGVLMQVISVAIPLFVAGRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNE1</accession>
    <name>A0AAE0JNE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_13495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062820855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNE1"/>
    <dbReference type="GeneID" id="87858009"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="620" mass="67437" checksum="684EDE3468032B22" modified="2024-05-29" version="1">MFRGGSSKPDQGAEGSRKPPQSPEAQRAYNQMRDVEEESKRTGRLSEALRQRERDRRNVIGHSPYLEIPTPQRRPRSRTGSIGSTGPASTQGSDGGVEDCGRKRRGHRTKPLEEPQRLRTAFIRTYVGACGECRTRKVKCTHFDDAELEANYQALRRSRLSVSPSSPSLHIPISPPVFYSPVQCPNELVGVGSHTVGFPNQPIVNHHEHLPDDIVLESPTLVNTSRGGLFLSKEDAPTNINAAYSPAYSPSYPAPLGFGEPYTPFPNSYPGSPMLSSPASSVGDVDKPLGLLTNDLIWECKRGAIDSWAVAPTDNGSYQCHARFPNHITFLEHYRTQHEPFVNEKIVRRCKCCGAFEGPFALSCTKCQNDACLLCDASGPLDTWYYGTMMPPAPSLTSGTSTITTGQGFGNGLLGPPSFYGSNSYGPNCHGSNPYTSNSYGIYGSSYAGSTSNQTFGTAPTPRSEHSFHQVTSKQGFTRHRDENSTSPTTIKDHSKGPFRDHHFPQKSFAKCASPTTFSLILKSAKSFSFSNLNLNFPCLALAHYLILLLLLPLGSSDANTTTAPSSSLIKRAAEDMPLVSAVCIALGVFGMWLFRSGSQSVEEVAEEGRASLLPMSLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNV7</accession>
    <name>A0AAE0JNV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centromere kinetochore component CENP-T-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_415057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686158.1">
        <property type="nucleotide sequence ID" value="XM_062823961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNV7"/>
    <dbReference type="GeneID" id="87861115"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF5">
        <property type="entry name" value="CENP-T_HISTONE H4 HISTONE FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="457"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3354780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="534" mass="57982" checksum="F2FD44280F4046DE" modified="2024-05-29" version="1">MADPNNPPQPPARTPSKPSSSQIPVRTTPGIPFVPRAAYTPGPGARTPRGLLISAHNTPNPNATPHVRAAYRAIDSRRAAILTPHHARRRSLREARETPRNFLLQLGKVLAPKSERIPSSSSSPGSALSGAAGGGGQEEGDTSEELTFDISTRSRYGDDDEEELPKRPRLSLPIGGGGGLGDMEEGDWEDDMDDDLPQPHRSAGLEDLTENFTVQSIELPRRMDPEKDQHRIRDSMGRLSDFPQPHGQQQQQSDGIDSGFFPPAAIEDDEFGNAEDRIPDEFSRLDSDETRRRETIGGEGGLGLLGAGGRDSDFHIEVPVGMDESTFMIASPTRQFEMGQAAEAAATSGQGGGFAELMDRRSDSYDDNDDDGNDIGPTFDDYDNDDGMGMDLDNNHDQDQAAGSDEEMTKLSGYTPTAARVSLSASAAREKLGFFREEGGERGGFSKIKATKKISKHGIEYTSLSPAMVKRLAQTFAKTSGAKGNISPEALKAIMQASDWFFEQLGDDLSAYAKHAHRKTIDMSDMLTLMKRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP48</accession>
    <name>A0AAE0JP48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_40408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686610.1">
        <property type="nucleotide sequence ID" value="XM_062823800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP48"/>
    <dbReference type="GeneID" id="87860954"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="219" mass="24056" checksum="E826ED9EE7EFD931" modified="2024-05-29" version="1">MLNSQHTSSIHLSWCQSVPIRPTKSSAEPVLCPTDQPTILRPDSPLVTAFSRAVYPPIKAGFSNLRVLANPKITDCDGNSEREGLSSQANYQTTLHLLLRTKDVVPSPTSIFNSRSSVLLCPSKAPGCSARQEVPEFPDRYVGVFSPGNPAGLLDSLWRLHSRLVSTWTDRCNMMRGQHNAKELPSQPAGSFASLLGRRLPSHRVFQVLKLDCAAIQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPD0</accession>
    <name>A0AAE0JPD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_451269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686620.1">
        <property type="nucleotide sequence ID" value="XM_062826045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPD0"/>
    <dbReference type="GeneID" id="87863199"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="63" mass="6991" checksum="505431A2A175D20B" modified="2024-05-29" version="1" fragment="single">EEDQEQDEEQDQGQDKYQEHGNNENSNQNSDNDTDAAISVGCGDAQIKVDSNTKDTNTDTDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPD6</accession>
    <name>A0AAE0JPD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_41209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686634.1">
        <property type="nucleotide sequence ID" value="XM_062823842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPD6"/>
    <dbReference type="GeneID" id="87860996"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF16">
        <property type="entry name" value="BACILYSIN BIOSYNTHESIS OXIDOREDUCTASE BACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3355256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="43524" checksum="0CF0F17CC20E9574" modified="2024-05-29" version="1">MDNSITTDDLSWSIVDTIKQSPPIDVTAPYDTKSLAGKTILITGGASGFGAAFARKWAKHGSHIIIGDVNDSAGEELIAELCSLPGSSKHHYYQHCDVTKWEDQVSLFKMAARASPTRGIDAVVAGAGISEQGDVASGAPGVFDNPSGLDSDDSIPPPPPPLNVLNVNLTGVMYTTHLALFWLPRNGGVSRLDLDNPPSSHLSENQPIRDRHLLLVSSIAGLAPLPGQTEYTASKHGVLGLFRSLRATSWTKGIRCNVLCPYFVDTPIIPWRGLALLAGGSKAEIEDVVDAATRLMADEGVVGRGLVIGGRQRVVGGRVVVVDAGHAEGEGEGKGDGGGIRSPPGAVWEVHAHDYEMVEVFVYRFVKILNMVRTVRGWVGTLKDLWGIYLSRRGGGGAKAAKAKAKNVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ46</accession>
    <name>A0AAE0JQ46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_53017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686984.1">
        <property type="nucleotide sequence ID" value="XM_062828921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ46"/>
    <dbReference type="GeneID" id="87866075"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041900718" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="231" mass="24586" checksum="12D41A0561599240" modified="2024-05-29" version="1">MLTSTLLALASAALASAHTVITYPGWRGNNLKDNEAFPYGMQWMYPCGGLTLTQNRTYWPTTGGAISFQPGWFQGHATAFIYVNLGVGNDGPDGRPKNMSFPMVSPFQIIGPGKNPYPGTFCLPQVSVPAGFTFKEGDNATIQLVELAVHGAALYSCVDITFVPPGDPRVANVNESNCFNSTDLGAADLYTMKILEAGRDNLAVTNSAAASVARMAGWVPLVAGGLWMMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQI3</accession>
    <name>A0AAE0JQI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.12</ecNumber>
            <ecNumber evidence="10">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_53370</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="13"/>
    <dbReference type="EC" id="1.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686996.1">
        <property type="nucleotide sequence ID" value="XM_062828985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQI3"/>
    <dbReference type="GeneID" id="87866139"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="17">
        <location>
            <begin position="14"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3355618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="383" mass="40462" checksum="170D67D355E1D35A" modified="2024-05-29" version="1">MATDGKSNLSFVLNKPLDVCFQDKPVPKINSPHDVLVAINYTGICGSDVHYWLHGAIGHFVVKDPMVLGHESAGTIVAVGDAVKTLSVGDRVALEPGYPCRRCVQCLSGHYNLCPDMKFAATPPYDGTLTGFWTAPADFCYKLPETVSLQEGALIEPLAVAVHITKQAKIQPGQTVVVMGAGPVGLLCAAVAKAYGAFKVVSVDIIPSKLEFAKSFAATHTYLSQRVSPEENARNIIAAADLGDGADAVIDASGAEPSIQAALHVVRQGGHYVQGGMGKDNITFPIMALCIKEVTASGSFRYGSGDYKLAIQLVEQGKVDVKKLVNGVVAFKDAEEAFKKVKEGEVIKILIAGPNEKVETSLDTTVDEKKLEEAKASGGSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQW9</accession>
    <name>A0AAE0JQW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair metallo-beta-lactamase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_58461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687173.1">
        <property type="nucleotide sequence ID" value="XM_062830903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQW9"/>
    <dbReference type="GeneID" id="87868057"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="807"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="862"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111541" checksum="9EB6AB5D81CBA08F" modified="2024-05-29" version="1">MPPKSSSSSSSAGKLTGSSSSKTPVKSARNRGYITKTPISSKPKPKPNASILNYFKKAADETLFIGEGGVGVEDLEGGDELEVEGEREGEGEIEGGDVKGVEEEKRFNELGGPSKKRRVSSDAEEEVRGKKVKGGEVEVRKEAEKEEVKPQSANKEEKLAVPPSSGAQSAKSAKKLRRGPFLDDSDEEDDEDEDEEKGAAHVKPAGLSGDEGREKREESTDKTEPKPLKEVTDRPRVPLLRQETSGARADTHTKQEEEDKESAKDDADQVDEDPQEDKENHDNDLQGEELREKRYVQEQARLEAKERGFLGDDDDFDEMMLDDAGFIDEIEDDDDLTFPPADPDAITESCPICNASLAGVTSDQATAHVNACLDGNPTPLPPPPVPATAKQRVPKIKDESQESTNLVDDTMTDLTEGSKRFASRAAIARPGQANPFTLPGDDDDPNRGPDAKPKSNGSSAFSKLMSSHAESSAWATAAAAESASRGMPAYKRTCPFYKIMPNFSICVDAFRYGAVQGCKAYFLSHFHSDHYMGLSASWVHGPIYCSKVTGSLVKTQLRTAAKYVVELEFGETVPVAETGGTVMVTMIEANHCPGSSLFLFEKKVGKEGRTQRILHCGDFRACPAHVEHPLLKPETLDKVTGKTRQQKIDVCYLDTTYLNPRYSFPPQEDVIQACAEVCAKLDKGLKDGNEAEWERLLRVREGGGNAKEGKDVSQFFGYNSKRRGDGGITSNPTPPEEEQEDTKTKPPPNAFTALTSSSSSRKNRLLVVCGTYSIGKERICVAIAQALRSKIFASPSKIRITKQLGDPELSALMTSDPREAQVHMQALGEIRADTLAEYLELHRSNGFSRIVGFRPSGWSYRPGSGSNNNNSSSHPSHQIPPDLDTGPPASVPVTATLPPSSLPITHLLHGNRFRPRFFARNVVPQRGSGKEAMCFGVPYSEHSSFRELALFLMALRVEKVVPTVNVGSEASRARMKGWIDRWVGERRRGGLVRVLHEDEEKVKGQKFWDGKDGSGGGVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQX8</accession>
    <name>A0AAE0JQX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_46327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686767.1">
        <property type="nucleotide sequence ID" value="XM_062826694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQX8"/>
    <dbReference type="GeneID" id="87863848"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000038">
        <property type="entry name" value="exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000073">
        <property type="entry name" value="Putative Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3355389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="246" mass="26864" checksum="46C8A78B1C5BC851" modified="2024-05-29" version="1">MSTESPLVVLPGEVIDPSLIPTHKKNPLRLGPGLRHIPPSEIVPTVAGQLVVDHRKTSMWIEYNGGRYIPSQGDLIIGQIARSATDFYYVSLSPYTPNATLPHLAFESATKKTRPQLSPGELVYARVSLANRHMDPELECVNSSTGKADGLGPLKDGMVFDVSLGFARRLLMAKSREEGKVEVLEALGEEGLAFETAVGRNGKVWVGSESVKTVVVVGRALRETDERGLGVEAQRKLVKKLVREMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR56</accession>
    <name>A0AAE0JR56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_545463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687641.1">
        <property type="nucleotide sequence ID" value="XM_062829379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR56"/>
    <dbReference type="GeneID" id="87866533"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3356264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="378" mass="41839" checksum="70F8C4E1770ABCD2" modified="2024-05-29" version="1">MLPKAEIPPLNKAPGTGPLPIRPSSSVILLSPANQVLLLHRVAKSTSFASAHVFPGGNLSSFHEGDDYPLPKDAELHRDSEAYRLAAVRETFEESGILLARRQDGGGLLELSEEELEEGRREVFGDRVKFTAWLEGKGGEADIENLIPFTRWITPQNQRKRFTTQMYLYMLPLNTTTAESQTRTVVQTPTHDGGVEHTAALFDSPSTWLAKASAGEIILYPPQFYLLTLISRFLPKQSSNYDEQREKLISFLRRVPTSSVKHPTSDIPWAEKVMSPEVVSFAKQGSYGNGRVILGLAKPGQELMDSGRGGDVERVVLVDFRKEEVEEVKEEQTEGGEVVKKVVKTAVRVPRDLEVMERAEAMAMAAAPEKKGKGSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRG6</accession>
    <name>A0AAE0JRG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_439302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687522.1">
        <property type="nucleotide sequence ID" value="XM_062825404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRG6"/>
    <dbReference type="GeneID" id="87862558"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3356145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="135" mass="15013" checksum="29FE716D4BCC0FD7" modified="2024-05-29" version="1">METRSGRATDELLMLVLWVGETGCFSSLSRRSRRDAGQWGDGERQGNEGNESGYLRMRGLFLCTVAASDRWMLVALSQAPQRIPQLQLRLKEHSSCSRGFQAAGVQCVVGSRRVPSLQFTVPRGWRPCGRITVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRW8</accession>
    <name>A0AAE0JRW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inhibitor of apoptosis-promoting Bax1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_454552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687660.1">
        <property type="nucleotide sequence ID" value="XM_062826199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRW8"/>
    <dbReference type="GeneID" id="87863353"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3356283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="352" mass="38099" checksum="FAEAB904867BC042" modified="2024-05-29" version="1">MSFTLTIRAGPARLASRIPEFAKTSSGPAAAIRAFHKSAPKTTNFFTSRTTTPSLIAQKPATNSLLARLQGARRGYQYQSHSQPQQDNGLLMRKLLVGGAMVGGTWVTLQFMFNRETRADGGMPAYESSYLNKTFMHTGLGIGIIGLSAYQMLQTGFTYRLMATNPWVVAIGGLALSFGSMLATRAIDPENYIPKYACWAVFNATQAAFVAPLLAMAPPALLARAGLYTLAMMGAISFVGATAKQEKYLYIGGPLLAGAAIVAVSGFAPLVLPATAVRTLAFTENLWLYGGLAVFGGFTLYDVQKVLYHARLAQAGVIKEDPVNESISLELDFLNIFVRMVQILMMQQNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JSK6</accession>
    <name>A0AAE0JSK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_73624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687651.1">
        <property type="nucleotide sequence ID" value="XM_062831339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JSK6"/>
    <dbReference type="GeneID" id="87868493"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3356274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="168" mass="19138" checksum="63D320D2B00659E8" modified="2024-05-29" version="1">MTRVTGEYSLVSLSLFRLCFSFVGWFRWLEETVVGGLTSLPAQAVVTRYHLQLHWTGDMTGRTSGPEFQKAAKRPLVSAPRWAHGLIFWRYKVRYENCPPNLRTFHPKTSGNSCVVSDRQGKGKLSRFPGCHGGVGIGDECNYTIIFCIVVVVMVDDQRREKKGRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJC5</accession>
    <name>A0AAE0MJC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_393578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676773.1">
        <property type="nucleotide sequence ID" value="XM_062823759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJC5"/>
    <dbReference type="GeneID" id="87860913"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="120" mass="13374" checksum="51C1278454334A6F" modified="2024-05-29" version="1" fragment="single">MRVVEATLAMTSRRPLRPVHAVRACPQAHQAVPLYRCSLSRARAILKTFNAQSGASLLDWTRLAPVAWFGRSWECTGGVVRRPGVRSCDHGLGRSGQDLTDEVVLRAVPWKLDRYHGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MKA0</accession>
    <name>A0AAE0MKA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_333281</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676984.1">
        <property type="nucleotide sequence ID" value="XM_062823539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MKA0"/>
    <dbReference type="GeneID" id="87860693"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3334818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="332" mass="37808" checksum="D707A301B2B4CF21" modified="2024-05-29" version="1">MFNPRDIEAYRRDEKLGHKMLTPEERIRLLKPYLPSPPLHPSEQANKRAMEEQQRLGVRRFLKRHWHLLVFTIIHALFSLYIRIRQAYHQVVNKVSSVYHHHHRAPDLIYNDVKDLRRLPNHLSVILTLDEDARGGTGLAKLIEEASDIAAWCASARIPQLSIYEKTGTLKGYLPRVHRSMTQKLAAYFGPNTPGIGIRAPHCPSIETAPTLAASRIENEGLKHLSVMILSAEDGRDSIVDLTKTLADMSQRGKISTSDITIELVDAELSESVMGETDLLLLFGPRVELVGYPPWQVRLTEISHVQDNEGVNYQVFYRGLLKYAGAQMRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MKH6</accession>
    <name>A0AAE0MKH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_82834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676595.1">
        <property type="nucleotide sequence ID" value="XM_062831463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MKH6"/>
    <dbReference type="GeneID" id="87868617"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="529" mass="60604" checksum="90193C1EF35DBC8F" modified="2024-05-29" version="1">MNCWNISRDLKPDTRSSFLPPSPNIFLIHSPHHQHPAKACPYHQHPAKTFKAKPIMSSIRATSPGYDAPFDRQPEPRGPFLETHYPHYEDWNKHLADDLKIKNSNNEWKHSFQKMTYSLRSWFPYFSSKEALQQPPPQPPVKLRPPPEAKRKFKSVLISHHFRAEITRYLAESIHNWETVNPTEWYMELRHFFIDLPTQLRELEEHLTGTSSMSSINDNEENQADTRALANWTSYQLPPGFAGPTSVSVYPHRRYPNLRHSRRIVFSQRLNIKDNHNSGWLAGRWLVVAYLFAATPEAVQDLDVKSILLSSCTPGRGNINTMSSLNAYNAVNPPLSISSGSPEWWLLPTRDIFFQLQRRYDLMTMAEANTTDEMLATAFISHYPDVYHKPFAYGYDYDSSDADYKRRLRDMEGRLRDMEGRLRDMERPRPLPFVRARHGHGHGVGGGILPELNDRCQWIDRMWPVLMTGQDIKKQTEGVKTAGTPCGDTYGASSTTSSISSICRTPSTSSASSQDGYSTTTFDDDDEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMQ9</accession>
    <name>A0AAE0MMQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_304764</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677271.1">
        <property type="nucleotide sequence ID" value="XM_062823200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMQ9"/>
    <dbReference type="GeneID" id="87860354"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="224"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="355"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3337820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="392" mass="44895" checksum="14968DF4D0FB7593" modified="2024-05-29" version="1">MTDKVLDDISHRRYNPLNGSWLLVSPHRTKRPWQGQQEAPALNKLPEYDPQCYLCPGNKRAQGDSNPHYKNTFAFVNDYSAVKEEQQEYHPQKDAPGDGDDDIASLLLQAQPATGRCYVLTFSAKHDTTLADMSASEIVPVIETWTRIYASHLSPSHPLQAAAARALSEIPPNPDGEVEPAKKQQLRYMQIFENKGAAMGCSNPHPHCQIWTTSTLPEEPGKELAQMTKYHREHKGRHLLEDYVKVEMQKAERVVWQNDAFLVVCPWWAVWPFEVLVIAKRHVRALVELTGEERLQFAEAVQEVTRRYDNLFETNFPYSSGIHQAPLGCTEEEAEMSWFHMHFYPPLLRSATVRKFLVGYELMAEPQRDITPEQATARLRDCGGELYRKLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMR4</accession>
    <name>A0AAE0MMR4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_305733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677286.1">
        <property type="nucleotide sequence ID" value="XM_062823208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860362"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1410"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1824"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3337835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1845" mass="200953" checksum="086B2049E8BC8644" modified="2024-05-29" version="1">MAAMSPQRPQDNRRARLLELAAAVGVTELPSLPPLPPIRLPTPSPQDDLQAEELLRQRRAAENPESSQSSLKRAFSSTKKPWEAKEIFDVLDNHVASGGSPAVANVLIRKLLELGGNPNIKASKGSRSGSILSRRKSMESLERSQILQRAIQNRQTDMIAVLSHYADDLTLNVALPDAIRSKDLTILSLLLQRGANIAQSQNGQIEFRQLCIAGGYPDLVGLILQSSGGFSLQLLSLCLIDASRKGCLQTVWRLSRSVADADFDTAEALRTAIGQSRVDIALAILTGRQPPTAGGAGLMESFRQLLNQSIGPNEKLFLTEALLCAGAPGDMVAVALQQACQAENIDMIHLLVENGASVEYQEAKVLCDTISRGNCNLLQLLLNDRTRLSPNLASRCVGVIPTTISPENRYAFLNILLRKGAGGAALGDALIAAVRAGDGQSVNLLLTPYFPEDTVPEGKPRKGSLQMKHARHEVASVDHLNGMALNNGVMMVNIDMVKKLLTGKPSPSTLEQVFPQVKKLAPNERYLITEAFLAAGLSGPCLSNALTEAIEEQHPRRDDRFISLLLRYTEGTHSDNNSGILSSIAVGDVPLLRKMLKRPLTPQTSAAAMVKAMAINNQEVRYTIVELLLQAGAGREGDEVSAALSQLLSAQPLDVQLFSLLLKHGNVDANFKDGEPVTLAVRDPDPAILELVVQYGKPTPETVNHGLETLSKMPTTAAKAAKMSLLLRHTKQKDHLDVLLYNEVQTILQTPLDTRNYDVVGTLLSAGADINSHNAAAFCCAVKASSTPLTDLMLSVKPAPDSLAAALRHSLNIPIPSDRQNFTRKLVEAGAPSSEVNRALNYALHAHSSDYPLIELLSAYADSTDGKALGFAVEKQDGQAVELILAKSSRKYPAAVLNTTFTQAVKLKDPEICASLLKRGVSGSEISDALIAAASNGNLTLVNILMSHGASLEHQEGQAVVEACKSAAIPVLGALLHPTAQVKKQTLVKGFEAASVSVTDLEDRTAVFRLLLERGVDGEVVDRQLVAAGTYGDDGEALVRLLLAYGADPDYNSGEAIWNATRGAALKSLKLMLGVEKANDRQKKPSQDTLLKALKASRKLSQDARYQVTEWLFCAGLEPSEDVHTALHRAVKEEPDVRLIRLLLTHGASPLMNGCETLIDATQSFRVDVLEALLTFDVPGKDVSWTFQHAFTPETAEAWMTEQGFQIAEMLLEKGAEGGEPLFPALNVAVDAYGTENEALARRFATLLLQHGASVTCQDGLVLQKAAKKADSELIQLILEQSPDSHSVSMAFPHIFDADLSEQEILSLIELFICYNFDGERLDVMTPTSPPILLRALNKYPRSEKLLETLLDAGYYHDQLTTMKVMDGGEEEQVNLLFWALSQPQKRISSSIIQVLIDRGAKVNFETRVSKQTPLMLAIQHRRPDLVKALLLAGADVDVADVENNTPMALATAIGGELGTAMMASLLAAGPSMNDGSLHNAARKLNLEAVKVLIEFGHDPDFPSVIHGGRSALGELCLNAAEAGPLSSSQEKKMEKVVAELIKQGSDLSIQADGKSVLLLALHSTDPLPITRALLKAGVWKTINASDHQWTDGVHTYSPTQYLLRILPPNSTDRSALLELLKSYRCRDVYYANDGPQPDGAVNLPPELLRAERERRARAERIAKETEEHHIAIARTKEIATMQNKIFLARAELEDSRIRRQRDEEIEAVRSRQAVEEEGFAAELHRRKAEREASMKHERQLLEAGLTRARLVSEAELEMEERKQGQTAQWEQQRLQSAKQLSEVRVQERREMERIEAVSDARMVKRLGEHKKLVETQERLARSLNGAVPPGGGRRQVGYITGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNU4</accession>
    <name>A0AAE0MNU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_477264</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677390.1">
        <property type="nucleotide sequence ID" value="XM_062827421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNU4"/>
    <dbReference type="GeneID" id="87864575"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="197"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="401"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="797"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="725"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3337939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="100654" checksum="3BB7A0BFE6B9B700" modified="2024-05-29" version="1">MSDIPNDTAKTEEAQTPVSLSGMVSTLVPVLITSAIYIAVFLVLRKSNRRYYAPRTYLGSLRENERSPSLSSGLFSWFKDFWKIPDVYALQHQSLDAYLYLRYLRMAFTICFVGCCITWPVLFPVNATGGNKLQQLDILTYGNIHRDTQYSRYYAHVFIGWIFFGFVMYLIMRECIFYINLRQAFLLSPLYSQRISSRTVLFTAVPEPYLDEQKLRKIFGTSVKNVWITSETKEVDELVKERDKVALRLEKAEVKLIKLANKIRRKAMNKGAVDDIDKQAPLDAESGSIAARWVPRKKRPTHRLGPLGLIGKKVDTIDWCREELMRLIPEAEAAQDKYREGAFKKVPGVFIEFKTQADAEGAAQILAHHQGLHMTPKYIGIRPSEIVWSSLAIPWWQRVIRRYAVYAFITAMIVFWAIPVGVVGIISNVNFLETISFLTWLKKIPSVIMGVVTGLLPSVALSILMSLVPVVIRICAKLAGEPSLSRVELFTQNAYFAFQVIQVFLVATVASSATAVAKKIADNPGSVTSLLAENLPKSSNFYISYFIVQGLSIATSVLTQVVGFFVFNLLYKFLASTPRAMYAKWANLSAISWGSTLPVYTNIVVIAIAYATIAPLMLGWAALAMGLFYLAWRYNVLFVTDTQIDTRGLIYPRAIKQLYTGIYLAEICMIGLFGASVAPGPLVLMVIFLIFTILFHISMNSALNPLMYNLPLDLLAEEEGPLLDTPTDLHAAENEHGGGPTNGNSPTTYTEKVPTNGTNGAQSRAEDPILGAKEASDASKHQPNHMTGKKPNFLIKFLKPWIYSDYNALRAFLPKGVQLDPYAAEVERDAYCPPSVTSDVPLLWIPNDANGAGVSRQEVEHTSRAIPITDEGCELDEKGHLVWDQEGTRPPIWEEKIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP33</accession>
    <name>A0AAE0MP33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding La domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_297342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678696.1">
        <property type="nucleotide sequence ID" value="XM_062823104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP33"/>
    <dbReference type="GeneID" id="87860258"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="180"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41602" checksum="E0220C52F4F38D2B" modified="2024-05-29" version="1">MSDTTANTEAAPAVAPAVENVQTEVQTEAVEAPVAEAALAAEEAPKTEDASKEEEKKPEATKSIDRADFKNNRKLDPSTQPVTDDPVKIRNQVEFYFSDSNLPTDKFMWETTGGVENKPVSLKTICSFKRMQMFQPYSAVVGALKESAFLEVSGEEGQETVKRKKAYTSSSDAQKARLAASVYVKGFGEEGGSTQFDIEAFFTKFGQVNLVKLRRTEQNEFKGSVFVEFKTEEEANAFVALNPAPKWQDQELVIKKKKDYLDEKTQLIKEGKMEPGTSKKKIFFEGSIKGADRGRGRGGRSGGDKGDWKSRRDNDQRNGFKGGRGRGRGGRGGRGGRGGRDNRDRNNDNNNKRAREDDGDKSAEPAAKKVDTKAEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPT7</accession>
    <name>A0AAE0MPT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_510316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679054.1">
        <property type="nucleotide sequence ID" value="XM_062828388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPT7"/>
    <dbReference type="GeneID" id="87865542"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="263" mass="29292" checksum="4056849F5FF3680D" modified="2024-05-29" version="1">MGNFVMKSMVIDCHSPSDTENAEILCTYGASHLKHLIESVNEGWNNSIPLTSTRPQPDYSVGFRRGAFTEDQLAKLSPFIGDFIAGDQSLFMATYYMYFPFLTCEVKCGAAALDIADRQNAHSMTLAVRATVELFRAVKREDEVNRKILAFSVSHDHTSFDFTALDGKDKWTTYRFTKNVYEIWMPKHFENICSAINQLPSELDFDVPPLSETTGLSQDLGNLMQLDASCASLPDERGSQSSNAGQEAVTPGTSFSEPKRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPT9</accession>
    <name>A0AAE0MPT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_473952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679848.1">
        <property type="nucleotide sequence ID" value="XM_062827222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPT9"/>
    <dbReference type="SMR" id="A0AAE0MPT9"/>
    <dbReference type="GeneID" id="87864376"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="156" mass="17769" checksum="B8A12B133AC1A6CE" modified="2024-05-29" version="1">MSLVSGEKSNFNHILRLLNTNVDGKQKVVYSLTKIKGVGRRYSNLVCKKADVDLSKRAGELTSEELERIVTIMQNPTAYKIPAWFLNRQRDIVDGKDSQILANGVDSKLRDDLERLKKIRAHRGLRHYWGLRVRGQHTKTTGRRGRTVGVSKKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPY5</accession>
    <name>A0AAE0MPY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_473121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679596.1">
        <property type="nucleotide sequence ID" value="XM_062827180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPY5"/>
    <dbReference type="GeneID" id="87864334"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MR06_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_577247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830685.1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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    </feature>
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    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3343254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR89</accession>
    <name>A0AAE0MR89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_242315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062822342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859496"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF630">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2884" mass="326516" checksum="B7E3214DD010FDB5" modified="2024-05-29" version="1">MASFFPPLGAGDPVLQICNNDNNTDRLVYCNKILPSEERLRTSWQWGTLIVGIAGLALPVLLTVILTIYHRLRQSISDSYTKRKRKSPSGRKNPGSPSSRPEFKIPSSTKTFQFLDGGVSGDRGVVVQQLVGGTVYISPLSSCTDPTPFQPLQATPTQDIIRLGLVDAKDVSPADLPAWETHISDFILSDDVSGVVLKVADLAKEDEETAASLFARLHQRVVPIVLNLGLEEETEFVNNVDFSGLVGVIVENACILPNGDRRDYFRSEKLRELMNKCAKERLERPHFFVAFHDLWEQQPSVAVVCRGEKVASHFEAIYQHGPRHVASGLKMTQPPVSGFEYLRKPETSDLQTAWLQQKKKVYVGDDNELIDQTSRLDVDRIASIVPDVKKLLQPVEQTTKKQEWWSDEPELSFPPPYREVAPARDEFWECDHRGEALSALGCIPLTASATDMQYEAILATQTHLRDLNMLQRLRPAEVDKLVMAYRNFQQETAHPHLFTPLVDGLVEGKVCVYKGLDTGFKVPDGEAHFWGISVPRSEDGDVDIFISRSNPSDVATILHIWLAHNGIARVDRYEEELRLENNMGSDLPLPTSIQTAINMCSPSEVLFFLQQLQVSRLTHPFRIVMEAYCRAVLLDESSTIAWNDAHCRLYLEGKVSMRDLLERRLTEFVRMGATALPSADGLVAVAAAIEHRVRESLYSGNVDALNAIRNPLTYALDPMNQYHDNKFVDVNTDLIALMFFTTVRKLALEDVYLEATDHCPLFSQADQAAVFAELWVLGSQCEAFFGIHPRALGKIIYDQYTAYLRKNPPPTPSDDGDRNGHMTVYSKPKPSQREPGDEYEDPARRGFRDRMKLSYWREKLADFGALSIFCMPAVLDILLLTFVGRGLFMTAYMGEDNILAACYGLLIALLISAGVTGWVGSIGNYYLCNFAYTNMVFFHAQRLSGGFVLTLLVGLVGFIVFTVKTSVYAGLVFFGYLVLLATYLNVLGIMATMHQEGSPLTSGRSVLWRTIPLLLISPALSSFVHGKDIAIYLSVGYGFLALLIFQYRKLCHEWMGWLNNIPKFTEADIHSWYEHRMNQSSVASPTEKPNADETKKLALQAFRDAIKRQQGRVFGAAHDGLIHKVAEGLPYINWILRMDGPPEEVVDVFSPPWFAQLAEAQKKRLQMSQGLKEHSVFFLFRQARYDIGQNVGLFVVCLMDRWVSVIMSGSGIANVFPNFTSRYAICFAILYFCLSIMVLDITLKKYWQFSYDLPKGILSSDAELFALRQKWQQTRRNQYIGALLTLATRLLATFGLTTIGVWLFVEEAQILALYYLYCLGYTGVMVFQFNRCFTTSVRAHVLSILISAVIGFIVGCLLYLMPKGLIVSVDVIGLCVASVFAAVSTSYWAIRKPKQMDLKEDGANGDKPNTWKQQKIGHSDNSFTGKKPAQVKDLPGDLLLAKQETPLARSVSETLRDGQSNFPGNSETVSWREDVLNTALAMWLDEKIRVTVCPRGTFLDAGLSECVSFSELKDDELHITTGFLPEEEANLATWQPLLACMIGEAILYHTARGIIGLDTAKAVHAEHILSGADRSFTVSKRIAFQLATEDRQGLYRIREQTNQELMKHLCLETSIDSEWVSLPRPVQETILSRIQGMSASQSRDFPTWMEEKGVDLRCSNFHVKLCLELYLMAGERVMMYNSAFNTSTDTLCYLPEPDSESQETSPLMDNGKKGKHLHWTHKILFYVPLNFVKWVAIISGAGSNIERELWYSLRKMPRIRKVLMWLILAICQMCFQIRDTWIFMILIFHHNALVQIWRLARKGTPRTLYKNRIVVVMRRRALTGFAKLNEYGKLMLNIYEGHLKEAPEEKTQPVATAVYDHTYRLITKSVKKGKDEVLSSFTYGEGNKSRRPTEKYVVDGTTVKRCHYDERRRISHGIIKFGNVEYSFRYFYKSSDKGSHDVLKAEYELKADHPFVLTVYWGTPPKEKVGECNWTPSDRVGQVDRSTYGRTFTTVITYPHRRDPVETTYMEENGRQITVDRPPRIFEHEDVLLQRPTDVSFEDDDLFIYHRRSSVERMAKNLKQTYSFASRLNPMSWFSMRKKSIYRPVPTWWLRTELWDIWRKSGTLDAVTACWMDELILREEPLLRRYWSARNSGQLSQARMILDADIDQISAAIEIEKHVGELCMLPIKTADLYAMGLGKDANQITTKPQDCFNDSENRISVIFNDIGCWPESPGGVSNCRRDLVNGHTTIRNHVLAESANEYGIPRFQVERNVQSLKVVPLWGLDGRVPNHGLIENLLEMQVEDKIVRTDIDRDVVDTFIPLLRLFVKGARSRHISKPDMYRYSNAILDMFQYFEHKDYNKTWNSKEVAAAWAEAWLIKYDDPDIADPEDNLAVQQPTMSDFRDSLAIFSSYFFIYAVQTPENCPKVFQSTHHGISSMFGVFLKYQRGATFGIWDHAILWRECCLNLSPAQSTLPIPVQSMVLAGIGLAMKLAYFHADVILPCTSFFNPIWETSLGTDTNRIGHEKKFARKIDPIINGVSNMDAFKPVDEVRTTTPTVVMLSNVQFIKDIRTAIRAADVIVNQYGFKEYRLFIYGAKDREPEYAINMTKLIEGCKLTEHVILKGFGKPQEILKDAWLFMNSSLSEGLPLAVGEAALAGVPVVATAVGATALVLTDPDNPSVAYGEVVPPNDPVGLARAQISMLAMAGPWAKFAGDVDKRGSVLPSLMLPDNLTPTDVAFLTKRMHEKTDARRKLGMLTREVVLKGFHGERYLREHEQMYWVQWHMAKMRRDPGLMRRRALVRRSEIRTFGRNSVQGSQMGEYDGESTVIYGGSEAGVWDEYREENSRSRSSYQGQRGKRLSKQHVREFELSRLTVATIGGAGPSGLSSGRVSMVSQRDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRT5</accession>
    <name>A0AAE0MRT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_509047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681932.1">
        <property type="nucleotide sequence ID" value="XM_062828277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRT5"/>
    <dbReference type="GeneID" id="87865431"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042042589" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18616" checksum="ADF871F0AFC2B543" modified="2024-05-29" version="1">MPVIQKFFLALTLGALRSQRMLCGVTRGERRYGYIRSHPSFHLSRLQLASPESLHLCGERGLCDYKRKCWEGFFHACLSRSLHPPISLVSHAQGRIPTCTPSSRITSTDSVEPRSATYRQRVIGFVSLRSPARRINRFALFYTRKDSWDDYLDDPAIDLAADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS71</accession>
    <name>A0AAE0MS71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_460103</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682398.1">
        <property type="nucleotide sequence ID" value="XM_062826511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS71"/>
    <dbReference type="GeneID" id="87863665"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3347316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="121" mass="14053" checksum="E67CE41253D4B426" modified="2024-05-29" version="1">MPQDMPPAGGYDAVQYKRNLPPSAFKPKTLLAFGGLIMVYGWYHLFHGIREQRELAREKMWSRIHLIPALQAEEDRDLVRRHLADVQREKELLGDKAVKVYHADRYVRPTFAITPGKIIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSB1</accession>
    <name>A0AAE0MSB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_428274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681020.1">
        <property type="nucleotide sequence ID" value="XM_062824748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSB1"/>
    <dbReference type="GeneID" id="87861902"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="433" mass="47150" checksum="828B17A65823152F" modified="2024-05-29" version="1">MSGLRKSGQHGRTARGAQDTPEDVELFKLLFTSTLTATVCIPHAADEMHQRQVIALAEGAQRRVTTPNDLDISLGIFASASCVEGHELKGAYSVVFRQMSPGTSDHGELFKMGWNQPSASDSQAANGLAIAQAISISGARLRTIAAGPQGAVPRKARVQVFTASNPALRHIINQAEIQGPRQALQTRVSSLVHQEVQKLSDIPGMRVELVLYWLPAKCGVTSLNEAHKIAMKCRKDGRNMFFVDGEMEERSSAHMPKSVSSIIADVLIRERLRINKERKTDGKATAATAASMKAAHKTTEPAMDQDVHALSLPTTPYFPIHPPYEELRDSSPPATETGQAAMPSGEETQEDIQAPLDEQALVDRQIVIECYENHIRSCREKAIPGRSTRGTEPIYSGIADTYCDYLGALVPDHPLVQVPDRPTHPLMAALFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSK1</accession>
    <name>A0AAE0MSK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_442741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681964.1">
        <property type="nucleotide sequence ID" value="XM_062825592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSK1"/>
    <dbReference type="GeneID" id="87862746"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000060">
        <property type="entry name" value="SNARE complex subunit (Syn8)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF423">
        <property type="entry name" value="SYNTAXIN-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="199"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3345351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="292" mass="32153" checksum="4408E704D1AA90FB" modified="2024-05-29" version="1">MSNPNALLLLADHIKLSLLERQRAKTLKLSSDTQDGHISRSLDQFREGLESLRAEHQRLQEAGDEAKASTLNDTLSSLQKQFDDLTSQFHGYASPATTSTLTQPNDPSLAEDFAHAQSSKPVATSTTTPPPIERRASKTVRFSSPNSDLEAQAPAANKSARSQLLPYRDDPVLGDDSAGYRDTIDGQDMDNTQVHAYHQRILEEQDAQLDALGASISRQRELSMQIGDELDSQVMMLDESERAVDRHQSALDRARDRVGRFARAANNSGEGKQMGIILALIIILVLLIVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSP7</accession>
    <name>A0AAE0MSP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_570125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682461.1">
        <property type="nucleotide sequence ID" value="XM_062830436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSP7"/>
    <dbReference type="GeneID" id="87867590"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="424" mass="46455" checksum="38DC88D09D183A45" modified="2024-05-29" version="1">MAPPRKPEDYTLRVTAGPSYDLSTHVQVPINSPRLTHIESDEGMDIDLNVRIQNYRGLPRGSPESSAYFDREPHRYNRDQYSIGLRFTPKRPKGVTGKSGGGGDGDGDGAVEGDGISAADLQFGNDFDHPIRNYLPPGVNTAMNILKWWIDPGLEGDAYADEPFLYGPALSSFNSVRVGAGEHDEEGGGLWVEEGASSESDNEDGDEDEDDDEPAGAEEKQEKGTEGDNHGAAGQGPKSNNNNNKPSSTSSKKWRAQVLANSGVGNDPKKRQKWALKDDAKKKWVWEYGRTYAVDFYNPYIDFGKCELKLPGFGVNVLRYWDGETGLRYVLRNRLTKKPYLVILFTLYPNDMVNEDGTLKPDALNATARASGGAKTEDYGEGECDAKAAADKKEVDSFKEDKALDEAREKLEGVPGTAGDDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSZ9</accession>
    <name>A0AAE0MSZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_538678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683147.1">
        <property type="nucleotide sequence ID" value="XM_062829095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSZ9"/>
    <dbReference type="GeneID" id="87866249"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="64"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="409"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="241"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="381"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="102"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3348065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="528" mass="56541" checksum="70D52018B037E646" modified="2024-05-29" version="1">MLSQRLIGRAAVRSAFKPSGLPVVVSPKLRRTYATESGLFANIKSWFSSKDSGRLTVDVPVEEKDLVIIGGGVAGYVAAIKAGQEGLKVACIEKRGTLGGTCLNVGCIPSKSLLNNSHLYHQILHDSKHRGIEVGDVKLNLAQLMKAKEQSVSGLTKGVEFLLKKNGVEYIKGTGTFADEHTVNVKLNDGGETAVKGKNILIATGSEVTPFPGLEIDEKRVISSTGAIALEKVPEKMLVIGGGIIGLEMASVWSRLGAEVTVIEFLEQIGGPGMDLEVAKSIQKILKKQGINFKTGTKVVSGDKTGEIVKLEVDSAKGGKPETLEGDVVLVAIGRRPYTEGLGLENIGLEKDERGRVIIDSEYRTQIPHIRCVGDVTFGPMLAHKAEEEAVAAIEYIKKGHGHVNYGCIPSVMYTFPEVAWVGQSEQELKKAGIPYRVGTFPFSANSRAKTNLDTEGMVKMIADPETDRILGVHIIGPNAGEMIAEGTLALEYGASSEDIARTCHAHPTLAEAFKEAAMATYSKAIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT82</accession>
    <name>A0AAE0MT82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_507627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682639.1">
        <property type="nucleotide sequence ID" value="XM_062828153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT82"/>
    <dbReference type="GeneID" id="87865307"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="241" mass="26319" checksum="7A167FF79B7BEABF" modified="2024-05-29" version="1">MASTISSVSPMQASIEAATNHLSFDPGRLLVPPETCLSSLLKQTLTQFTTTYALPDSLQALLLSQPSSLDRILNSIFDTSCLAFVTDKEFRIEAGLDDHDKVTLFVQAVAGMAMVFERLLLASSSSSRSSSYANSRSEDLTTCLFSRELQLFAESEQRRTMLDRVGGTSLLSHCYTKDELVSFVVATVEDRVPHPRHADGSSLLPLNAVGEDLLSDSVAWVSDRSCKNMGLPWGFTIMALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTA1</accession>
    <name>A0AAE0MTA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_523479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683583.1">
        <property type="nucleotide sequence ID" value="XM_062828796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTA1"/>
    <dbReference type="GeneID" id="87865950"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1164" mass="123391" checksum="4361AAEB2E8C0206" modified="2024-05-29" version="1">MPNSSPDQSPTSAGGVEEPSSPVQADFTDAQLKPAPLRLTRKSNSSGGQSDNSLSRSTSSATSGRTPNGANRNNRESLNTIIHRAATPSTFRTAPSQTSPKFASLVSKFEILDVMGNADAGALRLPSPEKNQKPPRVPTTPEEAELQRATQRQSQHQTENWSSQKHVHISLPKSSQAQRGARSQGVSSDAKVPIANGPKHWDPSNVAERRKLFESGSTGMFTAPSTVSKCLPIVTPVVTRTVARVPSQGEQKRGSEIVKPDQPFAISARRPVAAQVSAPALSSQQSATEGVGPKRERRKSVAALRMSFERSSLPDLQPETPSSAHRPFRRTLTQGLSTATEVPTPVTPGRGSKDPITPTRVRTLRSSEVFAQTYPRLGQATNQPVHGGDSNASSRLKQTQLHNTASRLVGSHDGNVSDAEVDSRRPVTRKNSDTPTRASARTSTRRPSSQHPLLLSRTLSVKITTGPQTMVTLQQPWASHSASGSLPLPTSHSHGSLDQRKLKSGSSSETSASAPLAPANRVKDLQKVFDNNPTGPGSAPFLPFIQKRRAQTLTLPVLVKSTLSAPIMVSTTVAVTTRKASRRSSQQQQQHQSSDVIPETASSTASSVVRTRKRSKTLPSSLGGYRRKTSGPAAGTGSSLGYTSYFQRRKIKKQQKQNMKSVGAGEDSPVKERISLFEQLGGGGGRGGSSSHGHSRNGGNGCGSIVGLPLSMHSKRKSSETTSSSQSRSDRSSQDTDLAAFGRKGRGSSSSGSKVMRVLSFGTSGNRDNGNRSSRNGKALRAAGRKISNAVSMSMSMSKRKDSGDGGEGKGKSKLKGSDGTKAQPLVMSSTNKETGESTFFVKGVLWKVSGSHGDLDLNVAVTEGQSSPEREERKRGESTTETTTTSFPSTRASASGSGSGSSGSAGAIARHPVLQHWPHLDKVNRTVPHHPHDRKSYGFLSLEDDNVAPEWSRGLDDDDPFLQPTRQPEVVTGSSSKIKKSATAPNDVGIMGRKRGFLPTRRSHGDVVEAARGPSTSLRKSFTMAVLPRLSSGNSSNDDHSQDGEGKQKGNKLTKEKGKEVRTTSFPPSLVDHVQSRRQSSISWGQRAAAAAFGIGQRLKERKGSGRSSSLLGKGVEAGAGTGTGGNSSANSDITASAATTTAAVAVPIPISTITTESLRHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTT6</accession>
    <name>A0AAE0MTT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_150010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682565.1">
        <property type="nucleotide sequence ID" value="XM_062821067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTT6"/>
    <dbReference type="GeneID" id="87858221"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="169"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3347483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="252" mass="26843" checksum="A60A2B589396CD00" modified="2024-05-29" version="1">MPDSQTPAQQRSTSRPRTPNRPTTPLRPSSRSSLRESARESIHGPSASFPLNAFEPAFAELADAMADLEANIMHFQLMHESLARFSEDFASFLYGLNMNAFCVDFPEGPLTESFKRMKEKEEREVAAGGGGSGQQGQQGQNMETGMGTGNGATTTVKQEREGFDGETTFMTTDTSFVDNPTSNISGPTPRKPSVAPKTPAPRQSRVPAPSGTTRGTSGRGVGRGVTPGSRTTSRGAITRSTSNGRVGGRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTV3</accession>
    <name>A0AAE0MTV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_539053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683631.1">
        <property type="nucleotide sequence ID" value="XM_062829106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTV3"/>
    <dbReference type="GeneID" id="87866260"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="185"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="392"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3348549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1004" mass="114651" checksum="024CC641B4FB1001" modified="2024-05-29" version="1">MATTIYQQKLWRLTVELGTPSILDEIYPELSQILQGHNEWLDVGNSLFKFPASPERCPVNIPNLAPGYALPESATMVRAQGISLLFEPSDIKPELDIIFIHGFTGHPRLTWTLDKKKAEKRRKANNDAPSHNVHNSGQTADVFWPKDLVPTTLPSARVMTFGYDAKIRHFSQGQISKNTVQDHARELLEQLRDKRPSDAKGSRPLVFIAHSLGGLVVREALTLASQHQNDQASTARYEDIFRSTVAIIFFGTPHRGADPRSSFHRLLSGSALRLGVDVNVHIVDALMPNVNNLQKQLSLDDFKTLAAQRGWIVYTFQEEYGVSSLFSRKTSDQPRKLTAPLPQPAPIPVAASVMEPGDESNEKRDLRQKLVQSLKFDQLGARSMNIEATYGNTCQWFLSKQEYVDWQKPGRHSPSSWFLWIKGKPGTGKSTLMKYLHSTRHCRGSTNILLSFFFNARGAYLEKSTIGCYRGLLFALLDGRDNLWPSLDHLGNTGSEYILKDNWTVASLTQTLTRAIQMAQSQAIEIWIDALDECEEDEVRKMVSFFEDLADLADSQDIDLKICFASRHYPSVTSRKGIDVILELQHNHDEDIARYIEAKLYVGAAQAEIKAELLRKYSGIFLWVVLVVHMLNREYARGNVLALRKRLDEIPADLHAVFEKVLANDEGDNEELVLLFQLVLRAEQALEPAELFVAIQRAKEPQGPLQRWDRNKPPMSPEALQRWVNSSSRGLAQVTRPSKVYPYYWWYNANKPTVQFIHESVRDYLLGKSGNKYTWSGLSKLGDAYQVWAKVCLDHILAVDISINDDLLDVLRYPLTAYAVAYLRQHTMRAIPNRSTEQEETERGYVLAKTYFRPLCSTERLEYREYVLANTYYRTLSVERIDYLERSIQAMHQSEETLQSAVDMGETEGGLSIFNNEWVYSRTELQAGFRFTKVTRARGEIWAYLKNTSEDPDVVIRRLINNELPNTCTSEDSDVLLRHCQDIEQLFLLPEISPLEQEKRFWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU03</accession>
    <name>A0AAE0MU03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_419594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684257.1">
        <property type="nucleotide sequence ID" value="XM_062824222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU03"/>
    <dbReference type="GeneID" id="87861376"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="372"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="776" mass="84394" checksum="11DF58E42BD26ED3" modified="2024-05-29" version="1">MSTSGRDSGRNSPAPANVPGRRPSSPGGSFRPGSFRPSSFRARSFGTSIPRADSIARLATPVPPQQPSGTPTPIPIEGGDADAGTGALSPLPGAGSHSAGPGVSALAAALSNTYGASPPRFGTPPARALSPAPSAAQLQRSATPTTNYGSFDTRPRLPSTGINGLAAYEDPEIIKRHLVQPGDGAGEDTSEGSKGKQPAEDDDEFSSLQLQGGDITRPIYRWAEEIEQRNKAKRSKSFSYPRPEPENEVLDINSIKVPGGFRRNYLRTHVREHSAHPDDYEHGAGQSAPPPRLLTTSFLEFLSLYGHFAGEELEEDDEVLKPGEYFTSGSEEGEWWSDEGSDEDHEPMEDSTLLTPSRRKRRRKERGGSGRNSPMSAAMLLLKSFVGTGVLFLPRAYLNGGMIFSNAVLLFVAALSYYCFVLLVTTRLKVEGSFGDIGGILYGKWMRNLILFSIVISQLGFVAAYIVFTSENLQAFILAVTNCKTYISISWLIVMQMIVFLPFSLLRDIGKLGFTALIADAFIVIGLAYLFYYDVLTLNTSGLADIIMFNQKDWTLFIGTAIFTFEGIGLIIPIQESMRNPEKFPKVMAIVMIIITTLFTVMGAVSYAAYGSKTETVVLLNLPQDDKMVNGVQFLYSLAILLSTPLQIFPAIRITENALFTKSGKYNPYIKWQKNVFRFFIVAFCALVAWAGADNLDKFVALVGNFACIPLVYIYPPMLHYKGVARSALWKFSDVALCIFGFIAMAYTTTLTVMSWASAGEGGGSPSYCDAKGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUA0</accession>
    <name>A0AAE0MUA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_97798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684036.1">
        <property type="nucleotide sequence ID" value="XM_062831640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUA0"/>
    <dbReference type="GeneID" id="87868794"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="96" mass="10660" checksum="C8A22C0E56A9792E" modified="2024-05-29" version="1">MPSLLCWAWRKWNGALDGEGNGKTVPETGAAFSAESSKPLSKTAPIDNLPLTGLSMGERTGSRVFQRVWSYVIFQWVSYAYKIRRSDDKASSLLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUA6</accession>
    <name>A0AAE0MUA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_98585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684066.1">
        <property type="nucleotide sequence ID" value="XM_062831652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUA6"/>
    <dbReference type="GeneID" id="87868806"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="210" mass="23927" checksum="D081EC64BB3D526E" modified="2024-05-29" version="1">MKNARTTSCCTNGTHEHTRTSHYITMSIINNGRIKCVFRVRSCQPSLRFGRRGEGKVEYSCTRRRRRRRRVLTTCEGIYHIGSNQFCTCMFFFLYFPASSCWGFFLPPRAGAFSCLLVLGLCMDMESDLHLRFGNGGGILGTAFWDRVAFLIAGWHKRTSAFWGTSCYQSSAFCICICYGCWLDTVVPSKRKTPLSGTWHGLLQPKFRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUE0</accession>
    <name>A0AAE0MUE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_116288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684677.1">
        <property type="nucleotide sequence ID" value="XM_062820656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUE0"/>
    <dbReference type="GeneID" id="87857810"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="212" mass="23820" checksum="7DB5CC77E0FCCDFB" modified="2024-05-29" version="1">MASSLRALRPAAATFARAAAVRPASVASRYVIAFSRSASNDSTDNQQKRDLDVGELDGATFKIEPLRRVGEDPATMRARLLYQSRKRGTLESDLILSTFAASHLGSMTPEQLKQYDLFLDENDWDIYYWATQEPPLPGQENQHLNPEKEQLPPNPRAGEWAQTIGTFKPAYRPVPARWKGSEILELLRAHVKERGMGSKGGMAFMPRLEEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUN3</accession>
    <name>A0AAE0MUN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_546023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684244.1">
        <property type="nucleotide sequence ID" value="XM_062829421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUN3"/>
    <dbReference type="GeneID" id="87866575"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3350949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="945" mass="102782" checksum="5C9E4106A85EB76E" modified="2024-05-29" version="1">MSEHLRPPPPAPAPASAPSHSPTLHAADTKYEGQDPEVDLTIGTRTPKPYYRQSFELLEPSERLIHRAATVALSQSQLSPTSAHSSNPASDSGTEADDEHFLKGLPAPKTRLHKGLRGKNEPLSGTSTPLLSSNAIDEDGRDPDLNPRSGTSIRTKRGEAERGRRRKEVVRRGAEVLLLACQGLLVASNHDVQPFLRSHRKELSALCWLSLTLLALYPLRLVAWAYRRGNPSKRLPLSVPTSFDPAPALYPQLIPLFVSLLVAQNVEGVVLPNVILSICSLPRPLIPGAGHWEEYSSTQWLLSCIPLVLGSSAADSEILALLYPLHQTLCLLLQRLTTTSLLIAELQLLSVALINVLLLAQSPQVVILKALLWGGGLGIIVLCGKVIQWGISLARVPKWRFKRPSTPKAGNTSGLWRFFKAAKRTYYDGKTDNEEVSSDSDDMGSGYRRHRNSATSSWDASFSKGRTREDSISSAEESSLRQANGTDVRFDVQEPPSPQQSSPRRHTLPSLGKIASIVRSQTSTPSGRRKRSASSSVRAFFSLTQGQAAVRKWLYAGWVYVCILITLLVGVREYVGRYALAENEPVGWALGYLFGDIPQLRLEVVKADLERWICLPIRADGEASGALGGWVQFVRQSIFGEANTRLLLSGYWLVVIIIGLAVVFRLSPIYEVDTRRKVFHFMMVAMFLPTIFIDPTYIALALSIVLAIFLLVDLLRASQLPPLSTPIAQFLTPYVDGRDLRGPVVISHIFLLIGCAIPLWLSLAALPRTGEGPLAGWEVPLRDISMVAGVVCVGLGDAAASLIGRRWGHRKWLWGGGKSIEGSIAFATAVFVGLMTANIWLFVGGWPSTVGTLSTVAREAELNDGFGAGAGAGASVGELVMDIMGRLWEALSQLPQASWSTTVVKTAACACMASLTEAVLTGGNDNVVVPVVLWTCVKSMDMNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUX2</accession>
    <name>A0AAE0MUX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spc98 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_489859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685248.1">
        <property type="nucleotide sequence ID" value="XM_062827723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUX2"/>
    <dbReference type="GeneID" id="87864877"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="227"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="533"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="811"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="923"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="957"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="979" mass="108921" checksum="5061E48D42ABE8B9" modified="2024-05-29" version="1">MASQHRAQKISSAIDSLIAHLIPENPYEDDHTAELRHDDYASAVKALLEQPSSPSYDADVNNASDLIKRKLIQGNPTQALRFSHLYTRLLSLPVLNQKWAILYFLYQLSDSPDPNEPLPLSPLPQQQPHFDPQFQPQIQAQTPPPQLLRPPQQAAWPAEPRIPAYEEVQDEEVMEDAPSPEGSHNVPPERPRHGRDQGHTPAQSHQAGPASRDERDVAHDPSEPALLRDLPFTLQGLSSATLPFLNDTTLKLPPTLPIPIISLLNTLAEPSLLYRGLNEFTKTPANGLLGQSLRAAISKELRSYLTLVATLETQIRRALSELDETAPRGGIGKTGVTLKRCVVWTREATMGLRLMSLIAEESKNKHGGQLITLIHSFSSSHGDPVVAAFAERLLVDVTRPFYDILRRWIYDGELLDPHMEFFVREQNPHDEERKDAKAKGQMSVWNSKYEIVEDMVPSIITSDFSKKVFLIGKSLNFIRHSCGDHKWVEDYSKKASRELKYGDTATLEAWIDEAHRETMSHLMHLLSDQFRVFDHLEALKRYILLGQGDFIALLMESLAPNLDRPAGAQYRHTLTAQLEHAIRGSNAQYDDPEITNRLDARMLQLSHGDIGWDCFTLEYKIDAPVDVVVTEWGNRQYLKVFNFLWRIKRVEFALASTWRKCMTGARGVLQTSDEKVLQTWKSTRGVLAEMVHFVGQLQYYILFEVIESSWTELQKNIHKENCTLDDLITAHTKYLTSITHKGLLGAKRRQYPQTGDPAAAPSTTDEERNSYMVQLSELLRTMLAYRDSVDGLYSWSVSDFTRRQEKETAGLIYSHRGGGGARTTQRDRADSQAASMADSMDLDPPYDYNNDSSATGGGGDAGAVKSEFPALQDRLKQLGANFKTRLQILLGDLAYQPDVDMRFLGVSMNFNDVYQPVRRKTKSSSSAAVPSGGATSVASGASSGSGGALQGQAQAAGGSGGQVGGGGTTNFRGTDTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVP0</accession>
    <name>A0AAE0MVP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_504737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686087.1">
        <property type="nucleotide sequence ID" value="XM_062827941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVP0"/>
    <dbReference type="GeneID" id="87865095"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="115" mass="13035" checksum="8BF7EA157A8FC015" modified="2024-05-29" version="1">MDMGAGVFNRGLDDSAKNAAAVSRTVFIAFAIECTVPLTPSPAEWARHTLHKVWLALVNTFLRMELRKPPIPPTVPNVEERKRRAFADVDEFTVTTHERSLCKKTKAERERAWCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVQ3</accession>
    <name>A0AAE0MVQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_112712</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16 17">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684560.1">
        <property type="nucleotide sequence ID" value="XM_062820598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVQ3"/>
    <dbReference type="GeneID" id="87857752"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="97"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="411"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3351265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="571" mass="64686" checksum="1E966AF00C281D5B" modified="2024-05-29" version="1">MATTTVTVTRSKKDANLPSENDRFLRCCADIANALIEDHEAAQNGRPQKDINLNSLRSKFAKKHKINNVPPLTAIIAAVPEHYKKYILPRLIAKPIRTSSGIAVVAVMCKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFEQARGRVDQLKSLGHSVDKVEYIIMGGTFMSLPESYRDEFISQLHNALSGYGTLNVDEAVRSGEQSNIKCVGITIETRPDYCLQPHLSSMLRYGCTRLEIGVQSLYEDVARDTNRGHTVAAVAETFCLAKDAGFKVVSHMMPDLPNVGMERDLDQFREYFENPAFRTDGLKIYPTLVIRGTGLYELWRTGRYQNYTPNGLIDLVARIMALVPPWTRIYRVQRDIPMPLVTSGVENGNLRELALARMKDFGTTCRDVRTREVGVNEVKNKIRPNQIELVRRDYTANGGWETFLAYEDPKQDILVGLLRLRKCSEKYTFREELVGQPTSLVRELHVYGMAVPLHVRDPRKFQHQGFGTLLMEEAERIARDEHGSVKISVISGVGVRSYYRKLGYWLDGPYMSKWLDGRPGPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVV4</accession>
    <name>A0AAE0MVV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_448125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685746.1">
        <property type="nucleotide sequence ID" value="XM_062825892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87863046"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="3">
        <location>
            <begin position="899"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="4">
        <location>
            <begin position="1707"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="2205"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="5">
        <location>
            <begin position="2284"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2434"/>
            <end position="2460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2585"/>
            <end position="2633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2442"/>
            <end position="2455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2603"/>
            <end position="2616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2617"/>
            <end position="2633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3354368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2633" mass="295729" checksum="E0347CB4D36D6059" modified="2024-05-29" version="1">MPSTTSGRIVKSQRGVKKTPHQKNHRWESFSTKISKLHSLDPLRKVRRHDLEAEDLNATTSYLRNGLDKWSELNISRAYVNFRNQVTSLTDSLAQILYHEDRIMDLLVEHTEKHHKETLEPLLDLITAFAHDLGVRFEKHYPRALRLIVNLASKVHDVEVIEWTFAALAFLFKYLSRLLVPDLRPTYDTVAPLMGKARQPGHIARFAAEAMSFLIKKAAAPSHKQTALPLIVQHVRDDLYSMEGTKQFGLYSQGIMVMFAEAIKGAGNSLHSTGSDVITALAKAVPEEELDLASEKPTIWTDVCCGVLTSTIHHSTPETFAPVETRIFEDAAATQRPILFVQLLGVAAGVRQGIRINDWALLVKTLGQLLTSLSTFKDNAEFMASPRLWQRIMMNAAIIWAQAPIDALLPSLSAFNGAMTKEPLMRWYIPFCSYLSDLHPDRFRGLFQKDFQKFIVAHWSDAANEDLLCVLIPHMIETGGLPSPHAKESFPLPQSWQDQIVSKFVRLEDTPFPESGGFGKDRETWKEKCLPMYSGLLRVLESTSVHPSTNARIAEVLLKKLKLALRPSSSLPTDEANFIVSDGFRAYLRMCAAAGSVDLSLAPLLRAAAPRFCRLPKFLEALLDYEQELNRKSQSSPEANNGRGNSPQEEDPLVKSLIKNLASTSHDLRLVSLRILDVLETTPDSNSALSTMIQVEELPLNQMQSVRAVAVHLRKLSQIYHHIEESLWLVQAIPSFLFGLTTVKLSPVWDDAVEAMKKISETKHGEEIVAELAFEWLEVPSPRWTGPFEPPIDDHRKAMTDFECTGLMRLQEAAVNTGKVVSELSQKMLSTFEEGQKAVELRSDRARSKALKVFTALPGSAEKRSRKIVPYLLSFTTEEGETPAAEENEDQPFSEEDGSWSLQDRKALVGVFSHFGNPKVLWQSQKVYTALLKLLANGDVELQKMALKAILAWKSDAIKPYQEHLEYLLDEARFKNELTVLFQGDNKIRPEHRAELMPVLLRLLYGRTISKKGAASGRHGLHNTRLAVIRQLDVADMGKFLDIALGELRSVRILDGDVVKESTFAEELIPVRKQVGLLNMVEAIINELGTAVVPYMDALVNAVLFCLITACRNLGAASEDPEEAEPVQNASLYKSVRTTGLKCLCKLFQNAQTFDWKPYENVMVKEIVSPRIEKLPAETTQGVSGVWRLLSTWAVLPKAALFLNIDKRILPKVIESLGVEKGKDEVKVHALEILKSLIGLAQAPAAESEYNELIKDELLVPNVNLMLKEIGGLLRDQTDIGKDLLGTAVDTVVLLAPIVEASSASVQDMVDIATYLLNQPARRVSPKIKGSILLILKQFLVLEDVQTNGELKKRVYSTVASLFGYFKDKENRQTLADVLLVFASTEPWAQEVADICRDLNSYKVKRLDEPDYNTRLTAFNRISGDRETPFTIDEWMPLLHNLLFYINQDEEFGVLSTNAADGLCKFIRAAEAAWAGPQQDAYTGIMSDIILPVIYAGSREASETVRREVVRVFGYLVAHLPSWDQVSDLTLLVPASDESDKAFFFHIMSPAIARQLQALRILEAANEKSEFRSKHISQFFIPLLEHFIFGKLEGGDDHGLSAQTIAAIAGLTASLEWQQYRAIMRRFVSFIESKPEWQKRLIRLLEKEVDVLRAAIAQRPSADAMDVDGVEPPKLCRLAKTIPDQEKLSAEIVNNFLPTPIKHLHEKDEATVSTRVPVGVIIAKLATLLPEPLLNEKLPGVLTDICHILRSKAWDAREMARDTLSKIAVILGPERFEFILKELRGALRSGPHLHVLSYTLHSMLLAVIPTFKQGDLDYCLSTIMAVLMDDIFGAAGQEKDAEDYVSKMKEVKSSKSQDSMELIAKTASITRLSDLTMPLQALLLEKLDLRTARKIDELLTRITKGLLENPAAASQEILVFCYEVMQEVYKAQKPEDGPKMDPRLKRYIVQKAAKRADGGITAKYTFKLIKFAIDILRAVLKKHDNLRTANNIAGFMSLLGDAVLSIEEEVKVAAFKLLTVIVKVPFKNGDSTALYKVATKEAIRSMTLSASTASELAQAALKLISVVLRDRREIPIKEPALDMLLSKLKDDLTEPLYRHVTFNFLRSVLERKMETASVYDTLDHVGTVMITNDDKDTRDLARGAFFQFLREYPQKRNRWEKQLKFIVANLKYEREGGRLSVMEVINLLLKKTSDDFVQEVAATCFIPLVFVLANDDSEKCRLAAAELIKETFRVADKERLTKFMTLMRNWAEQGENMAVLKLAIQAFGLYFEGREPTSKDKKDVNLVVDRITKVLGDDETVQSNWELVDTSLNTVQTLVAKHPQKVLSPASDVLWTEVRDTLAHENPTVKLTATRLLSMYLADFAQNAAGGQQQAPQQAPLHGSHGRELSKKEISDLVRLALNTFNVPEVDEPLAHEVVQILLFLGSYLDAKNTDDKKGADEKEEELEDEEEDEEAGVRKKHKKPVDMGYLFYKLASIIRKERAARPEMLVAKLSAMDLLESFCEKSDPSTLLGSIKTIIRPLRNLTDPSIPGPFSLNEVFKTRYELLKTKALSVLDVLQRKLGSSEYTRALLAVGQDIRERRNARSSKRKIEAITAPEKYGREKRKKFEKKKEKRKEKGREARDARQAYHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVX0</accession>
    <name>A0AAE0MVX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_416075</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686327.1">
        <property type="nucleotide sequence ID" value="XM_062824025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVX0"/>
    <dbReference type="GeneID" id="87861179"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="68"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3354949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="494" mass="55238" checksum="3194E37ADBE25522" modified="2024-05-29" version="1">MAVIDQDNFSNISWHSEQNGGTAASTAQADHHAPNSPEYARSGPDDGRTGDNAAGMEHDELDHSGGEILDCTVSDPHKENDGTKDAYVSYLITTNTTFPSFQKPKTTVRRRFTDFVFLYKVLCRDYQACAVPPLPDKQRMEYVRGDRFGTDFTARRAYSLQRFLARLALHPILRKADILHAFLESPDWNATMRSRSVRGSLASPGGLGDSTLGGSAAAGGGGGGVFDTFADSFMNAFTKVHKPDRRFIEIKEKSDKLDEDLNHIEKVVARVARREADIESDLKDLAEQFQKLITLEPGTETAVRAFAASVEDTASGLKKLKDHTDQDYLGSLRDMVAYSGALKNLLKAREQKQLDYEQLTEYLNKSTTDRDMLASGQSYGAGSALMSGAGGFIRSKIEDVRGVDHEQARRDRQRKLELRIEELTREVEVARNESESFAEQVSREVESFDWIKRVEFKRQFSGLADAHIEFYGEVMSVWEQYVMEMEKEGVVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWE9</accession>
    <name>A0AAE0MWE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin ANXC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_418274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686134.1">
        <property type="nucleotide sequence ID" value="XM_062824138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWE9"/>
    <dbReference type="GeneID" id="87861292"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF107">
        <property type="entry name" value="ANNEXIN ANXC4 (AFU_ORTHOLOGUE AFUA_3G07020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="85662" checksum="0B8F452C98D02F2F" modified="2024-05-29" version="1">MSSLQVDERSRGGRSRSPADPRREDEDWPRDRERSRARTSTANVVEAGVYPPANNNYRDVDPALAYEQLANYPPPAGDRGGDYYRSSPPSGDRDRNRDRDRDYGSSYNASAPSLGRPRERSLSRDRLRDQSRPRAQSRDRRPDPRESPEWGKNINRERPGEFGGMYLPPKYAATVVSADPAGSPHGSRDLFHGHGRTPSTSGRERNSSRERPPSPGYQRPRPSSYHAGAGRPDDKYGEPIGRPSGRTHSPNMSISSAYDLRPPSVVTIEPPHSGGGGYPSSPGRGHHEDDGKPPLKSAMRPGREKSPMPPTNRMSLLSVNTHTPHMSNGNLSVANAPASPMLESYHGTYQSMSPMPSPLMLPTQPGPNGSSYSFVEPLSPLYGSSSSDDEHHRKGGSGSGEKKGHTRTHSRRARFHDPIDDAARLAQALKGETRAPDTLTLIEILPGLTHEQVMDLRVEYKRLVKTGAERKGVNIAKHIRARLKDEDPTLMKACYTVALGRWESEAYWANFWYHGDKTRRELLIESLMGRTNEEIRKIKEGFSDKKYGDSLVKCMKMELKEDKFKKAVLMVLEEKRQEDVDQFGRPVRLDFELVADDVRTLRDAIKSERGGESAMLAIVVMRSEAHLKEVMRVYKETFRGANFARDALKRSGNLVGEVLAHILNGVINKPVRDAMLLNHALTMSKRDELRRELLISRLVRFHWDAGHMSRVKKAYHEHYGKDLQEAVKETTSGEWGEFCGQLCVSRMPDDVKKIERRPTDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWK7</accession>
    <name>A0AAE0MWK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_50953</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686913.1">
        <property type="nucleotide sequence ID" value="XM_062828322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWK7"/>
    <dbReference type="GeneID" id="87865476"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="559" mass="61610" checksum="5B76FB1652F178D1" modified="2024-05-29" version="1">MAPPKFLGLSGRPLSLAVSTVATTGFLLFGYDQGVMSGIITAPAFNNFFTPTRNNSTMQGLITAIYEIGCLIGAMFVLWTGDLLGRRKNIMVGAFIMALGVIIQVTCQAGSNPFAQLFVGRVVMGIGNGMNTSTIPTYQAECSKTSNRGLLICIEGGVIAFGTLIAYWIDYGASYGPDDLTWRFPIAFQLVFAIFICVPMFYLPESPRWLLSHGRTQDADRVIAALRGYEIDGPETIQERNLIVDSLRASGGFGQKSTPFKALFTGGKTQHFRRLLLGSSSQFMQQVGGCNAVIYYFPILFQDSIGETHNMSMLLGGINMIVYSIFATVSWFVIERVGRRRLFLIGTVGQMLSMVIVFACLIPNDPMKARGAAVGLFTYIAFFGATWLPLPWLYPAEVNPIRTRGKANAVSTCSNWMFNFLIVMVTPIMIDKIGWGTYLFFAVMNGCFLPIIYFFYPETAHRSLEEIDIIFAKGFAENISYVKAAKELPHLAPEEIEAYANRYGLVDRDSNGEGGNRRDEEKSRDRTGSDSDSPAHVDVVDERGVESGFGDGINTKNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWR9</accession>
    <name>A0AAE0MWR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_416768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686509.1">
        <property type="nucleotide sequence ID" value="XM_062824054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWR9"/>
    <dbReference type="GeneID" id="87861208"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="361" mass="41776" checksum="A568ABB49B2D4EDA" modified="2024-05-29" version="1">MTFPKQLDSVGHKDSQVVDHGKEEDRRRIGFMDLAVEIGLRIYDYVYDSHSVRHSKPPLWYLTQGSGRHVLKPVTSQATIKPSPLPYEETPDGNDTISHAPTRELLSAHRPMNYIPTALLLACRQIYYEARTIPFYENEFVFPSWHDVDSVQAARNFLNDRLCADWQRQSMRYVRIELDLSEDKSDKNNNDSSSKKAEAWEELCSAANWGAGLRGMRLCIDCKEKDLIKGSFAAMLDRAERPGLGGDGDQSGPEEEELSSFAWIFRGLVQLSSLRKLDVEIKRGRRYMTDDEKVGWCRLLEELLNMNCERDEEEEEEERERERDQKVSVMCAQTSYDPYNLEQVFGKISYPMMMWPLYAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXD8</accession>
    <name>A0AAE0MXD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM and PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_58738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687184.1">
        <property type="nucleotide sequence ID" value="XM_062830973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXD8"/>
    <dbReference type="GeneID" id="87868127"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
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    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
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    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="198"/>
            <end position="262"/>
        </location>
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    <feature type="domain" description="PH" evidence="2">
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            <begin position="687"/>
            <end position="852"/>
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            <end position="302"/>
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            <begin position="602"/>
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            <begin position="660"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50105"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355806.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="869" mass="96918" checksum="03B37C4AFE4B1E3D" modified="2024-05-29" version="1">MTANMDNLHYHVREHDRHNEMRQKTGSRVESFFSTNNVKDRPNSVYTEFMESDWEMEEDDIYSDMEDLAHDDEISPRNSIGSSKSGGQPSFTTMSSYDEVQTPRSVRQRGGFPFPFEEMKQVEGPRGPHLFRSSVSLHSIEYQNALTLSPVTERKAQEHDHFLQHTVHLTTLPSRSKRDSGPFRFTDVELDTRTLPEWTPEMVAQWMFNAGVELTTCERFVENDITGSILITLKFEDLKELGITSFGMRTRVWNEIHSMRNIQKPDPQPETPIEDEPDRKVERELRRNESVNKPKRKASKVRPKINDVISPLESVSIVGIEQLMPKPHSCSKGENCAKWKRNQKMIEAFKKDHPFVNIDEGGFIMVAGNPGNPQTAEAIDPFRPVSDAIPSVVASSDVMGPGDQPTLQYLQEATLRNVISRDPQDNVRQFLDFQNHHAVGSSEVPPTPPFELYPQQQAQGPHARLRALPKLAIPNEGGAVAGPVSARATSARRQSQVIPSFREMSDHSASSEEATPVGVYRFGTPFSEMDVPVTMTSIPIISRDVSQSVPPDMNYRHNPAPPRSMSRATIRRPSFPVMPALDENKIVTPLTAVQPQNKSFSQRATTQTQRPLQPPPRVQYPWSQTNRTTFERAIAPMPGSSAVIAPSKSAGTSPTESSHRVSNSPSSGSRLSPTSTQPTEDMTNGEAVSYQGLMKKRKTKMLRHEWHEHYFKLRGTRLTMHKDAATANNKTLEYIDIDDYAIACSSNANTSKLNAAFKAMHIRRGSGDAHSKDDIAAFSFQLIPQDGKAAVKGQLRKRENSIPGPSASSAAAANGASAIQGAVNGTGKMHHFAVKSRDERIDWMRELMLAKALKQKGEGAEVVVNGSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXP9</accession>
    <name>A0AAE0MXP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_414873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823951.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
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        <location>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="10129" mass="1101358" checksum="52256C661A256657" modified="2024-05-29" version="1">[encoded data, 10129 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0B9</accession>
    <name>A0AAE0J0B9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_436876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676752.1">
        <property type="nucleotide sequence ID" value="XM_062825268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0B9"/>
    <dbReference type="GeneID" id="87862422"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042277942" evidence="1">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="123" mass="12687" checksum="53FDED22774CAEF1" modified="2024-05-29" version="1" fragment="single">ITIPTFTAIIMKSQLAFLLTALSTVSAGPCKTATTTAPSPTIAPSCTFTGTQTQWATSGCDLSCDMSGFCIWDAAITKSCGCSSVPIVTTTVTLCPTRTPCQQCTTGWGIATYTQPCEATATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0Y2</accession>
    <name>A0AAE0J0Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_436369</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677079.1">
        <property type="nucleotide sequence ID" value="XM_062825241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0Y2"/>
    <dbReference type="GeneID" id="87862395"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000771">
        <property type="entry name" value="zinc finger protein 648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3334913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="292" mass="31194" checksum="1E616B7C0B638500" modified="2024-05-29" version="1">MLNSQNPAVTQPPTAGHGSSLPSLDFGNFRTSSSQNSYYPSATQQPQSSTQSSYYASPSTPQQGSYPGFQGAPPSQLSPTGYSPSTSQGNASRGLGSISSSGSSASGLQYVTGSRPQQYGLQSHHHYSLNGHGHGPVLSNMHQPGTPLAMVGMSGIHYGTHHPMPQYHRYGAGHDQLGPRQGDRPYKCDQCTQGFNRNHDLKRHKRIHLATKPYPCGNCEKSFSRKDALKRHRLVKGCGKNDQVNGNNTKPGGTTTGTAADNNTRPPGDYSVKMERIDENASDDGAVARLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J103</accession>
    <name>A0AAE0J103_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_480451</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677109.1">
        <property type="nucleotide sequence ID" value="XM_062827576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J103"/>
    <dbReference type="GeneID" id="87864730"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="464"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="621"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="621"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3334943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="672" mass="75063" checksum="E523165AB966F5D4" modified="2024-05-29" version="1">MASKNGPVLPQPGKENILITSALPYVNNVPHLGNIIGSVLSADVFARFCRARGLPTLYICGSDEYGTATETKALSEGVDPATLCAKYHALHKDVYDWFRISFDKFGRTPTDEHTGITQEIFAQLWKNGFIEERETTQAFCAVPEHNTFLADRYVEGECSICHDLGARGDQCDACGNLLDPIQPDKNAAGEDESKGTGWLINPRCKLDGSTPERRKTKHLYIRLDELNKEITAWLDKVENGWSANCVAITRSWINNGLKPRGITRDLKWGVPIPKGLEGLSEEEYANKVFYVWFDACIGYASITKCYTDEGNLEGRNWEKWWKNPDNVTLYQFMGKDNVPFHTIIFPGTQLGTKEKWTQVNHLSTTEYLNYEGGKFSKSKGVGVFGNNARDTGIDPDVWRYYLLSRRPESGDSEFKWEEFIDSNNNDLLKNLGNLCQRVVKFCQAKLDAKVPEYPKTPIASLDEYKEEINKLLKEYNEQVKGTKLRAGLATVLSISAVGNKLLQDNKLSNQLLTEEPERCNAVINLALNLLHLIAGVLTPYMPGTAQSILRQIGLKAAEGESDIPVVIPDTWTANALKAGEPIGTPELLFSQIPAAKLEEWREAYGGEELRKQKEIEAEKAAAKKLQREKEKEKKKAKKEKERLAKEQAAKEAAAAGGDAQPAAGETKELPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J705</accession>
    <name>A0AAE0J705_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_435452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677530.1">
        <property type="nucleotide sequence ID" value="XM_062825191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J705"/>
    <dbReference type="GeneID" id="87862345"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="100"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3338079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="551" mass="59836" checksum="15EABEF8A4A6B94B" modified="2024-05-29" version="1">MSRHQNGEQPTIRGGPEATSPHIPIHQSSTNTNDNDHRLKPPVLGTVANAQSSGISLPQIAQVDDADGSAATPWKNRFQTLWHWKPKAARYDPDNPPEFTMWINILFGFASCFTVSNLYYNQAVLNKIAETFDVTFEKASSVATLMQAGYCSGLLFICPLGDIFPRRPFILGLIAFTATLWIPLCLTTSFPSFATISFLCGATTVTPQLMLPLVGDLAPPARRASSLAVIVSGLSLGVLLARTLAGVLANFTSWRNIYWFGLGVQWLVFGLLYIWMPDYPSKNPDTKFNYFKMPWQIAKLLATEPLLLQAALVAFLHSGIFTSYWTTLSFLLSSPPYEYSSVVIGLFGLIGVVVIVCAPIYSRLIIDRLVPLVSAIMGLVVETVGVVVGTSVGSFNVAGPVVQAIMIDLGGQFTQIAMRSSIYGIQPLARNRVNTAYMVVSFAGQLTGTAVGNRLYAQGGWVYSGACGIAFGGFALIVCLVRGPREKGWIGWSGGWTFRREDLPPKKSETTTEEVLEEAGAVGHDDDGHRGVDLKNASTGRDGNHDGKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7N3</accession>
    <name>A0AAE0J7N3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_479013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677903.1">
        <property type="nucleotide sequence ID" value="XM_062827511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7N3"/>
    <dbReference type="GeneID" id="87864665"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3338452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="495" mass="52287" checksum="B71811E79F1C8E2F" modified="2024-05-29" version="1">MSGLATKQQSLKLFEKLKAKPANKICFDCGQKNPTWTSVPFGIYLCLDCSANHRNLGVHISFVRSTNLDQWQWDQLRIMKVGGNESATKFFQQNGGSAALNSKDPKTKYQSAAATKYKEELKKRAARDAREYPEEVVITDGDDATGSNTPAGEPDDDFFSSWDKPAIKKPTPPISRTSTPPVIGRTASPLLGNGKDIQRTASPLSKTDSDAPTPAPAASRITTSAALRKTTPGSSATGGPRKVGGGILGAKKPAAKLGVKKISADLIDFDEAEKKAKEEAERVEKLGYDPEAEEEKTAKKAETKASNIITPAAAPVSSSSSRSAAQEKSAAEVERLGMGVRKLGFGMVGKPGGAGAAGAGGAAAVKKNAGGFGSVGPIKASDADEEQYARNKFANQKAISSDEFFNKGNYDPSVKAETKARLQGFEGAQAISSNAYFGRPEEDASVEDYGDLESAAKDFIRKFGITASDDLENLTQMVGEGAGRLQGAIRAYLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8T1</accession>
    <name>A0AAE0J8T1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_511117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678086.1">
        <property type="nucleotide sequence ID" value="XM_062828456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8T1"/>
    <dbReference type="GeneID" id="87865610"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="364"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="648" mass="73311" checksum="4E105DA869235102" modified="2024-05-29" version="1">MSGLEIAGLVLGALPLAIEVLDRYGEVARRIDVFFKIRTEYQEWRRQLKYNNLLYERNLKELLLPLMIDDETEKDKIPELIKDPFGSWWTEPKTARLLQERLDDGYEVYMDCIQVIKQVMEDIVHELALGHSSVQSKITTPGEATMIARLRDSDNRSFQRFRFKFAVKGQEKRTRLFSKFEDYNRKLRDLLEGSDKLRDLSVQTPVTVQPKAAAIDTALCKFWVKADKFFNAIASSWNCRCNTHCANLLLRHRSNATPEFEVLFTKEQPSPATWNARKTKIVGKQGVNSEPEEEAKSRISLPIHTPSHKDIRPLKSALGKPEKIKRQNRNVRGVPVSQAVVSTTTVTLVEVKQEDKTAITSTVSTQTTTSKQIIHCLCTALEAPASPGIQGEPSYGYLINDDISYHIYDLPYEPTTQQHTAITLQNIIDGDLFHILERKQRYSIALTIASSFVQLLDSPWLPTTLTKTDIIFLRDSTSEDDDYFLDEDEPAFLNEPYVQQKLTATITPNKTKQETVPIGTSLDQLGIILLELCFGKRLKDQPCRRRYDAKSPATNDHVRAIYDVAAARDWQRKVQGEAGSDYASAVDWCLGGNRGCSGNDKSLEKSMSGRSGNGAKGAVERWRKDMLNNVVGRLKSSVDYLAGKGVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8T4</accession>
    <name>A0AAE0J8T4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_291788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678524.1">
        <property type="nucleotide sequence ID" value="XM_062823021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8T4"/>
    <dbReference type="GeneID" id="87860175"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="315"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3339164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="732" mass="83034" checksum="CC4D38C79FAC5DE5" modified="2024-05-29" version="1">MPVLRVRSQRLPPPGGEEGIRTPSPYKFKSPLTMSNMIPELPDMPDIGPDDDFRLVIKKLSLYIAENIRMPSTFEQLRTTAAGDCLRHLVDHLVLSCDHPAIVNALLALKWHYGAITEDKGLNDARASGCEIAAWRLLTHLSEREAVDYCLYEIPDPALEANRQSDEEETSQANEHSPLLARAWTESMANPRRKHEFPNPTGNNRRSLLLQSLTRLTMSMTGEVDSDGEEEDDPTSPFINLNALEIAAIADAKRFLSQNVVQKIITGIWNGDIIFWDNLSVHTEKKPRFYNPHTADPFSRLRVPKYLKSFEVVFFASFLFLYYAVLVERHPTRITPLEIFLYLWLAAFSYDELSEWIDAGSIFYAADIWNIFDMAIMAIGFTYMVLRIVGLRTQNEELIDLAFDVLALEALFMVPRVCSILSLSPYWGTLIPCLKEMAKDFIKFMVLVVIIYLGFLTTFSLVGRDSFPLRDMTWFLTKIFFGSTYVGFDIMRKIDPVFGPPLMILFVMLSSILLMGSLTGMLSNSFSRVITHAREEYLFVYSIYVLEASTSNRLTHFYPPFNLLALVIFRPLRLFLPSDDKFRRARIILLKATHLPIVFTIAIYEWIRGTSLKGATYSAVKAPPHGAPIAIPAMMRKLAGPRREMRGRRSVTSLQSDQAAQGRPGMSSLERRISVHQARQAEEAQEDSTYAERATDVEVRIADLAAKIDRLTELVIAMQTQQSKTLGDVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8T6</accession>
    <name>A0AAE0J8T6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_290681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678475.1">
        <property type="nucleotide sequence ID" value="XM_062823005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8T6"/>
    <dbReference type="GeneID" id="87860159"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042094658" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10176" checksum="45146B4F915D8F28" modified="2024-05-29" version="1">MGAIMATCLCHVLFGFIEGAVEGFRCSHLCEVDDSQHWQPLSRTSFSGTVEIGDGKVTGNTSHFLTLALKFGLCHPVCYMTLVEVDALALFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J957</accession>
    <name>A0AAE0J957_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_531537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678734.1">
        <property type="nucleotide sequence ID" value="XM_062828944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J957"/>
    <dbReference type="GeneID" id="87866098"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3339374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="210" mass="22206" checksum="45FFD482C312F019" modified="2024-05-29" version="1">MSNQTPEAQAAAAAHLKLIEQLDIHSIHKSFRNTHWRPNQRRNKNIKTILGDAQRKEANSILATPQDASGAATPAPVGDDGLSTSGTSTPAVPSTNGANANGTTVSLAQASRSLSKLVLEKSLNVPSKGSNGLAASLSSAPVATYTNIESAPSLAPMRRYCDITGLSAPYIDPKTRLRYHNAEVFAMIRSLPQGVGEQFLEARGAHTVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9D4</accession>
    <name>A0AAE0J9D4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_298670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678745.1">
        <property type="nucleotide sequence ID" value="XM_062823120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9D4"/>
    <dbReference type="GeneID" id="87860274"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3339385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="161" mass="18515" checksum="E3B181C9AF538FD7" modified="2024-05-29" version="1">MLRKSPIIHQFFHPTLRMKRQERAELYTPTVLKAGVSRSRSRTRVSLAVHPHPINWIQSSPGLFVSLVQKANALLDIGKRSAFYRLTTVDRYRPVLKESERDIRGFCGVLNPCHYPIILQTEDSSSLQRPIRAPKLPCSTYGRRTKLTNKPVLNCMDVFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9H6</accession>
    <name>A0AAE0J9H6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_511658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678819.1">
        <property type="nucleotide sequence ID" value="XM_062828505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9H6"/>
    <dbReference type="GeneID" id="87865659"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042063632" description="Thioredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="11"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="313"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3339459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="820" mass="91902" checksum="271A91F12B8F624A" modified="2024-05-29" version="1">MRWLPLFLGAARVAVAASTTTTTEAEDDVGVTEYTKFNDVSIPPLIELTPDNWEKESKASKWLMVKHYSPYCPHCIDFAPTYQTLYEFYYTSKPVGNENANFTNFYDFRFGTINCVAYYDLCSAHKASSYPTTTLYKNGEQVEALKGVKSMVVLSEVVEKALEETKPGSRPAKLELPKPGEISAPGYVPKVGAIKDTKEASKVDSVKDVPKVDLVKDSTKVDSVKDMPKVDLVKDSAKVEQPVKDTFITGNDEYLMPTPKTEDKVADKVVEKVADKATETKAVSKADPSVEAKAKVETAKVEKAKEEEKKSTPAAYYEAPAAAAAAAASIKGNKPKTTPNPNGISQPLTAESFQSQVTMTQQPWFIKFYAPWCHHCQAMAANWAQVAREMKGRLNIGEVNCEQEVRLCKDVRVTGYPTIQFFRGGERAEYTGLRGLGDFLAYAEKAIDISNGVQDVDAASFKALEEKEEVIFVYFYDHATTTEDFLALERLPLSLIGRAKLVKTRDPEMYDRFKITTWPRLLVSREGRPTYYQPLTPNEMRGTRQVLDWMKSVWLPIVPEMTASNAREIMDGKIVVLGLLNRDDEESFTGAIREMKSAAGEWMDKQIQLFQLERQELRNAKQLRIEEAEDRNDQRALRNAKNIRINMDRADRKEITFAWVDGVFWQRWIRTTYGIDVKDTGDRIIINDEDNRRYWDQTTTGNPIVPSRTSILETITKISQNPLNIKPKLTISAFEKMFFDIRMTFSEHPYLSMGCILGIAFGCLSWFRNSARAQRRAGHGTHFKLEEGGVGAPGEKGSTGGFIQSVFGGSGGSSSGPKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA64</accession>
    <name>A0AAE0JA64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_476722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678881.1">
        <property type="nucleotide sequence ID" value="XM_062827386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA64"/>
    <dbReference type="GeneID" id="87864540"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="194" mass="21283" checksum="2A985D43C066A7FB" modified="2024-05-29" version="1">MSAPAVPPFLRRILPGKGLRWASNSGRNILQPERRDEAVSAALQVRVGRPNRRMTSRPAKREVERLLVDIVDTCTRLVRENPAMMNPMDFMAGVGMTGVGNDDFNIWDFRGRLIPRPGSRGHRAWGAPQPSHFPSPLSGHHRGPPAVPHLRCRAPARTQPFPLLSSGGCSRQISGGCCVLGCRQRPDPAPHRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA68</accession>
    <name>A0AAE0JA68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Argonaute siRNA chaperone complex subunit Arb1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_302069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678853.1">
        <property type="nucleotide sequence ID" value="XM_062823152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA68"/>
    <dbReference type="GeneID" id="87860306"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="542" mass="59883" checksum="D667F681091DB52C" modified="2024-05-29" version="1">MSTHANDSASSGDVPVEVTAARPSSDNDSAAAQVEEDSKPSNDNTSPVDGKENMALTEDAKPKKKKKSKKSKSKKKRPTGFEEYFCDAPMTPAEYEEERKSIYPPNRPFVDRIEECIQRYRARRRFDSAKENLFSRYLFLGGIDTTARQFQGTASLTSHDLDGLDKDDIRDIAANDYVERKPGLHASRYYNPNQPEHWDVDFTGVVAGFLSETLVRLTTPGAADYAAGVDLVSNFLKYVDLHDVCPEYAEDIKNAQRVCQKAHEEMPSLVQILRLLPGNFSSAARLVTCEDDDENAWAREVMDDQTCRRKIGIVMSILMSSKCGHENGIKFEELTGFPTVTKTITQQAYEVVGIVLPNAECHAKFKNINKHLGDANANAIKPCGLLQVKPTVIRNGWENTMHKSVEDVTYNLVMEEEILALMKVGFKFEMDICLLNYGMGFIKKSVDGHPTFYEFLPQELMWGYKEPVANPRPGPSIHNPTGSFEGGDGMGDFLNNDPEDDAPGDAAPGGATPVDTAPVGVAPVGSASVSYAPEDDDVEWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAB0</accession>
    <name>A0AAE0JAB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_528603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679239.1">
        <property type="nucleotide sequence ID" value="XM_062828897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAB0"/>
    <dbReference type="GeneID" id="87866051"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="354" mass="40532" checksum="49FF95491C1A6028" modified="2024-05-29" version="1">MNPPQAPFAPANQAYPQEKAYPQDQVYPQEQVYPQEQVYPQEQVYPQEQVNPKKQAYPQATNPEKKNDNENNHFEELLLDPAEESLVRAMRAGKFRNFPALKLRGPRSVEADRLFMKLSPMDCRLKREQDNKMLKRFKYYKHILQAPKGSNNLFVCIPSHPWPEYSQPLTCLYCNLTTDHVNIPRPKTSEVRILHNQNLCPYHDYYLLSGCSLGYHELLALNAFEQWGISFGTTRRKKPGPRRTIGPDRYLYEKRSHIKYFIDRMREEVVEKRGHLVTTEADLKLGTFLGEGSGSGYVFEACEREGKAKRIGVIGDGRPVVKGKETGNDEDEEDEEAMEEVGPAGGGAPLTAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAJ3</accession>
    <name>A0AAE0JAJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_472297</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679359.1">
        <property type="nucleotide sequence ID" value="XM_062827141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAJ3"/>
    <dbReference type="GeneID" id="87864295"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3340417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="435" mass="46033" checksum="E49B30202EFFE3EE" modified="2024-05-29" version="1">MRRVVVTGLGAITPLAVGVRPTWRRLLDSHSGIVSVADLEPQDKWKELTSTVAGLVPTALRNKQNVAEEQTWKAGDWLEPSDQRRMSLFAQYSVAATEMALQDAGWKPTKQEDLEATGVCMGSGIGNLDDIYSTSVTYDKEGYKKVSPLFVPKILINLGAGHIAMRYGFRGPNHSATTACTTGAHSIGDASRFIAFGDADVMVAGGSESCIHPLTFAGFGRSRSLSTAYNHDPTSACRPFDKDRAGFVVAEGSAVLILEELEHAKRRGARILAELKGYGCSGDAHHMTAPREDGSGAFLSMKRALKNADVKPGEVDYINAHATGTAVGDAAEAIAIRSLMMGEEGVDNESKITVSSTKGAIGHLLGAAGAIESVFSVLAIAEGAIPPTLNLTNPNVGVGFNFVPVQAQQKEVKVAMSNSFGFGGTNASLVFSKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAK5</accession>
    <name>A0AAE0JAK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_444517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679454.1">
        <property type="nucleotide sequence ID" value="XM_062825687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAK5"/>
    <dbReference type="GeneID" id="87862841"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40001" checksum="967A1AA57D468F66" modified="2024-05-29" version="1">MLLVPGACSYHDFVAPGRCGASRRALIGAAIEDIGIATLMVFGGTGQIGRSLVKSCLNHGDSVTVVGRIFESTREQMAQAHLHHPQAENAFGTLCDVRDYASVNRVIDQTLDRFGRIDCIANCSGYGVIGACEDQDEHEIRNQFETNFMGTVHIIQASLPYFREQGAGRYIIFSSTSGALGVPGLGPYCATKYAVEGLIEAMLYEVDAFNIKATLVEPGLVRRDEADTSMVPRWGHFLIKPASEPYSHATSPALHAKRMVQWLGDKQPTSAQKCADLVWQLGHCSYPPLRLLLGSYAIESIRDRLRSVTEELEDWKHLHFPVAPEPGSSGENRGEDGENKGGENVDREGDMEMEVEETSPTSNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAN5</accession>
    <name>A0AAE0JAN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_261222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679434.1">
        <property type="nucleotide sequence ID" value="XM_062822615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAN5"/>
    <dbReference type="GeneID" id="87859769"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="588" mass="63249" checksum="784D6C40291988E7" modified="2024-05-29" version="1">MTTPGLRDNKTSSDSLPAKAPNMATVTSTQTEATPAMSPSTPDIRPIRRAVTVDEGSQQAQLRRRTINPQSTPETPFGQFRRRSSTFSDYSLDAARRNLQHEILNPASFASDEQGPSESSTMPLAFALLPAVAGMFHHKGSDFITDIIMIVLAAVFLHWSLTVPWNMYKSAQQVRIENEQIAESALDEDGASPTVTPLQTPSAEVQEPRTPIESKHTTSSSEEDARLNIPEIPIAQQHKHHSSRHARRVQKALGELYTIESLALVLCFVSPLMMAYLLQIMRNQFKSEGGLVSDFSLTLYILAAEVRPFSHLIKLIQARTLHLQRIVHKNPYSESAVAPTKLQEILERLNELEQRATGSKPSNSDNNGQSDGSEGGQDQQNLNPKVRDGMVREVRNTIQPDLDALNRAVRRYEKKATVLAYQTEARLGALDGRLNDAIALAAAAAKAGGTGARPHGNNSRANGATGSNIGFSMLGMLAKALDTIVWAAVMPFQALLGFVVLFPLRAVAGFLKGVTGGSSRSRVASGKVSGTGNLGGARKGMNGNGFATGPGNSTGYPPYAGGGAEYGYSASGRRTTSGSGSGARYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAX7</accession>
    <name>A0AAE0JAX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_550781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679256.1">
        <property type="nucleotide sequence ID" value="XM_062829767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAX7"/>
    <dbReference type="GeneID" id="87866921"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="728" mass="78130" checksum="4DFE56ECD0BFC85A" modified="2024-05-29" version="1">MSGDQLACSSFGDQTAQPPTPTRTPISNTSSSPLLHTPKANRNYAEETAGWTPGFAKEYSLFINTPGYPREEEGPSEEFGSKKPAISSSGQKGSLSADRVAAGLTASANPSSSYPAQLLPPVEPLVGLSLPREPLVASSFNSLAFLNQLPHPAQTSSAQKILLDTVDPDRVQTVTPPPSRHKGERKLATRLDVSVMQNDQDFVQQGFLETSHQPDMDSYVTNQGDMFNFQLTGTTTGDFANQQPFWETDPSLEGMDIDFNGASSSLFRQEPHPPSRPMNSLNWETSTPNHFIPENVLVNGGRVVSGGGSEHVMVSQAPMQALMASSADQSMYTDTYATAIDNSFGIINTGVDPGLLFSRPSSASMDASLDAVAQGSSRGSSRQISQAAQSGSQGASVAKVPSRSELRRSASEREMEPRKKDKVRATSPVKPIGRPGLGRSLSENRGKRPGSRAILPALAPAPRPQSQLSNGAGLGISRPVFSQPSRSSGRLSPLKSSHQRLPSLTSIPETAGPRTRTQAKFTIDENGRARVETTLVVERDNPLAVRKRTSSQSVGGCRRWCSEDDDESSTDDEPIIIPSRNTSFSMPDPRKSRTAVNSFSHSQPNFSFSAQSTTSLGSFRSGGGFQGLDDESDEEILLNEVTPTSKMSGDAVNELLKLRENRMRQKPSPSKMRRLTSSSHSNSTGTIASMNFASRFTASPTALTETSLPTPSSSDATASISKMRARIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBC3</accession>
    <name>A0AAE0JBC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="8" type="ORF">B0H65DRAFT_275982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBC3"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="330" mass="37058" checksum="EB27592573822231" modified="2024-05-29" version="1">MSADTTTPIATTTSGEKPAHLEPSKLGTKEYWDALYTREISNHASNPSDEGTVWFDDSDAENKIVQFLDEQEHELFAGLFSRDDAAIMDLGCGNGSLLFALHDDGWEGRLCGVDYSEQSVELARRVLRTRVLGEDVVSEEVEDEEAEAEEEQKQKQEKEEEEEEEEEEEEEEDTQEEENNVGGIEFKVWDVLNGDFSTVQARPPSPSSSSSQPPSSDQNAGWDLILDKGTFDAVSLSDSRDSRGRRICENYGARVLQLLRPGGFFLVTSCNWTEEELKGWFETDFAEVYDGTKKKKLGLRQVGRVEYPSFSFGGVKGQTISTLCFQKRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBI6</accession>
    <name>A0AAE0JBI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_430588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679823.1">
        <property type="nucleotide sequence ID" value="XM_062824889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBI6"/>
    <dbReference type="GeneID" id="87862043"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="453"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="743" mass="82018" checksum="6FDBE510DFA580BF" modified="2024-05-29" version="1">MPPGKKTKKPKQQTLEAALGQPRVKPPTIKKISTRSSGKVKKPEDSASAAGSSPAAPTTTATTMTPTPTRQRQREDISPDRQLPASSAVFIPKISTAEAKKRTIVIDDSDSASEAEEYGGAAFEYDDLPVFSSQAVVTVTHNPRATGGSASGAQKAQKEVIVLDEEDEEDGMPLLTQRTRGVKRQITVLTDGEEDGDGDGDEGKIEGNGKGKNADEEDDDSDSDRILSSAVRRRTTRRGGEKLESSPAKKRRLIRKGNPSSASSAKGEEESDTSEAKKDEEKDEEDKKPRRLGKGRQKAATGTGPGSSAATSSTESQPVRAKRRAKKPMTEKEKARELLRRKRAGEPIDDLENEEEDEESEVELPKRGYYDTDSDNPALSEFEDEETDEEEAVKGGKENKGKGKKETKDKKTNKKDKKGKKRREISPDSEDTGDNDERKGNAGGSYEDEEMQDFISEDDSDAPIGAPDEVGIPLEFTRHAHKPLKEHFRDVVEWLVHYKVHLNFPEKTAGLYRLGWRKLDDEVRGLAQSKFASSAWKTDFYMALRARPYYTSGETHEQSLFSSNCAACGRSGHPAKFEITFSGSPYYKDFSHPKFLEPVPGNTSPSPSPDDEGDDPDEYDADGNTIPAASRTWKIGSVCHSNAETAHNLLHWQYALLDWVDTRLSEDGHLAAAAAIAKKREGETKEQRKKRTTKKKYKLVAKVVEEWEANGTVKALFREFKNMLEGARNKSTAGPRAQKGWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBL3</accession>
    <name>A0AAE0JBL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sas10 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_473205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679633.1">
        <property type="nucleotide sequence ID" value="XM_062827189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBL3"/>
    <dbReference type="GeneID" id="87864343"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="7">
        <location>
            <begin position="552"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="134"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="627" mass="70647" checksum="91B404803115C102" modified="2024-05-29" version="1">MAKKRKAPRPTGPAEPREVDAKDARLTVKTYKDVANSEDEYWENQDRIDFDDSDDGRQSKRRRQNKEEEFLEASDEEVFEEEESDEESEQEDAAPAKGKKVKTTVLSDEEMGGEEEEEGDEGWWGSSRKDYYNADQIETEADALEEEAEAKRLQAKKLAKMSEADFAFDESEWLGTKEEAEGEEDVITEKLNEVEITEDMGPEERYKLLQSRYPEFNYLAEEFRELQPILTTFQKEAEGKPAKSLEMVKFWTLGCYVASLASYFAILTSPARDSQGVSKTISPTELRDHEVMGTLMSCREAWLKVKELKPLKSVSSTSGMLSPPEDEGEFDDLSDDDMEDFKQMLKKNKRESKAELKAKAKKEAEKAKKARAVEQSLADLSNLLETTKTATKASKKSAKVDKRDDDERSDFGDEEILEAHVAKEKAARKKSLKFYTSQIVSKSAKRADAGRNAGGDDDIPYRERLRDRQARLNAEAEKRGKKGSKHGAALGEGDSDDEDKAVAKQVRGEEDEYYDMVAHNAAKKKGDKAAKYEALAAAKGARVVEETTVGPDGKRQINYQIQKNKGLTPHRKKENRNPRVKKRMMYAEKQKKLKSVKAVYKGGEGKGGYQGELSGIKTGLVKSVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCB5</accession>
    <name>A0AAE0JCB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_223271</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680352.1">
        <property type="nucleotide sequence ID" value="XM_062822082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859236"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001076">
        <property type="entry name" value="ATP-dependent DNA helicase MER3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000012">
        <property type="entry name" value="DEAD/DEAH box DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="285"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="499"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1240"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1350"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1508"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1250"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1532"/>
            <end position="1542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3342559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1565" mass="174979" checksum="A91FAD2F50D2556B" modified="2024-05-29" version="1">MTGRWRESARERIAQRQRERHRSDILDDRDELAMSPRPGYYPERYRDEHDRGQLGPPTSYYAEPPQPYADELDNFDRHFLAHPAPQTRDDEQYQIALSHLSRHARPHISPGYSSYMDATMSQSMSAGPPTSTMVPVTDDHLIPTPRTLEIISREPNHRLRELYGSHQQLTPPMHSAASYAHSPASQAPTKDTLHSLSSSSPTIRASAHKKQSASRRARQMSYVVEEPMEASQSSQPSLATHTDSTQSTPIVHGIRLVSVRQALPSRFQEVFPYELLNAVQSKCFGVVYGSTDNVVISAPTGSGKTAILELAICKLALDRGNENFKIVYQAPTKALCSEKARDWEKKFSHMGLKCAELTGDTSQAEMRRVGEASIIVTTPEKWDSITRKWQDHRKLLQLVELFLIDEVHILKDVRGATLEAVVSRMKTIGANVRFVALSATIPNSDDIAKWLGRNHTTQQLPAHREVFGEEFRPVKLQKYVYGYECNGNDFIFDKFLDSKLPMLLSKHSQRKPILVFCFTRKSCESTATMLAEYASALSETNSLWPIPKKRIPVVSRELQEIVQFGVAFHHAGLDVQDRVAIEQHFLRGDLSVICCTSTLAVGVNLPCHTVVMKGTVAFMDDKLQEYSDLEVMQMLGRAGRPQFDTSATAVILTRASNKLRYENMVSGREILESTLHLNLIEHLNSEICLGTISDLSSAKLWLGGTFLSVRLRRNPDHYRLTGDISNPSQIDDKLEEICERDIKLLQNTQLVTADAKFKCTEYGRAMSKYMVEFETMKLILKIPRAAGIDALITALAEAVEFKEFRIKPAERTLFREINKNPLIMYPVKEQVQHTQHKISLIVQVHLGCVQYPDSTEASKLRRQLMMEKKMIFERLQRLARAVIDCKGFDRDAPGVKSALELARALSAESWEGRPTQLTQIPNIGPVGMRKLASKGIRTVLELAEKEGIELERLMSRQPPFGKKLKADLDKFPRLDIEVSVVKYITPKRRNEDVTLNVQATLRYHNQNGPPNWLGRCPMLTFMIESSNGNLLYFWRGSLRKIDKQIGLVLPFPVPLKSPDERIICHLSCEEIVGTLVSKILKHEVPLAAFPSQQSRQGRTTPTNGGQTQRLLKETAEEYLDDDGIDDSDLLQAADEATSCAPAIHGAKYESESDPDEYPEVEELMEVVTQASEPAHQKFDRHLAANEADDSGDMENSQILDREPVQLPNGKWQCNHACSGGAPTKSGKPCTHKCCQEGIEKPRKRPTKKRKEIEQGDQKSESQGVLTQSSFDALNKISSAGSQVAVNKTIPRAATKKEAFEKPYEPVNKKPKLELPLQKQTIDGVDFDYIDLSFDDDEFQDIAAGVQRKTTATTTANQGQRTSIDSQSSHNEAWGIIQTQSEDARGPAASTQNMVADQSIMFPLPTQVYGDDPFDAGDLAILDGMMLEASNRHTTKSPFSIGGKDQVFYQTPSSQSLGPGMNLPDELVPLNPQSAGNINQSATVIDLDWDDVPMGGKDATHDDQSVSYTIEAPSPHGFAHGSPQTPNDVKSNGAKDQKPKIEGEPEWVSTMDPDIIDMLRGFVTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCD0</accession>
    <name>A0AAE0JCD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_429501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680011.1">
        <property type="nucleotide sequence ID" value="XM_062824827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCD0"/>
    <dbReference type="GeneID" id="87861981"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3342218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="423" mass="46150" checksum="715651ED83A43180" modified="2024-05-29" version="1" fragment="single">LGWGALTLSQAFIKGRGSLITTRLLIGAFEAGFYPTALAYLTAFYPPFDLAVRIALFYGQYAVAGAFSGVIAYAIFRIEHPTLKSWQLLFLIEGGATCLVALFAWAWLPKGPESAWFLTAEERALFRRCRVVDGVGVKGWTAQGDGEGTGYRVNGRCHDEDDTESQRMVAVPSAGDVEEEASGRLVTWREIVETVRDWKLWFLLLCNICASIPSTAFSVFLPLVVEGMGYSALQANLMSVPPFVFGALGVYLFALSSDRRQERGYHIMAGLAISAVGLAGIVLTTSPSGKYMALCILLFGSYVPPPLTAAWLSNTTRSPNKRALVLGVNGWGNLAGVIGSWVFRIGSEHDGGHGQEKRGDGYREPLLITFGFVGMAIMGYWAYTEVLRWENRRTGEAEAGKMVEESSRKRDSKNGCRIMDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCK2</accession>
    <name>A0AAE0JCK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_222282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680318.1">
        <property type="nucleotide sequence ID" value="XM_062822064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859218"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="363"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="885"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1280"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1510"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1225"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1313"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1408"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1510"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1572"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1596"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1651"/>
            <end position="1660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3342525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1682" mass="183599" checksum="5CA7FFB7245992C4" modified="2024-05-29" version="1">MTQTHLLWKYYWEDDVERFRRLLSPAAHGSQPAGRSSNITSCAAGGSGSLGTSPRPSGKPRKQPNSALSRIDVNSRDHVGLTLLLRAASSTTKNAVSFAEALIEHPAIDIYAQDPESGWNALHRALYAGNISIARMLLDKERRDLTRHTASLLRVGQLIKTKDHEGYSPFDLYNATIGERDLVALRELGGVQDEEDGSDNEAEVAQESVSRKSRHGALGEDLYTFGSNRNLTLGLGGEDDRQFPERVYLERPAQLLQRFYNEYLESAGLEDSTAQDLSDIPALVLNRPIVIEDVVMSKLHSAVLTTDPVSNLYVSGVGRGGRLGLGDENTRFKFTPVQGPLADKKVIQVALGQNHTMALDESRTLWTWGSNAHSQLGYTLPEPTKKDEDPISTTPRQVFSSLKKESILGIAASSIHSVAHTGISLYCWGKNVGQLALMDSDSRSLEYQQTPRKVAASLFSSPIVMVSAIDKATTVLLQNHTVCVFTGYGYNIVKFPFATIDTIGNLSMSNRYEPGGSQISYITSGGETIAALTRRGDLFTMHLDHKMETNPPATSTTNPSKIKGAVTQPQCIWSARKDGVRSVGVGEFGSVIISTHSGAVWRRIKRAKVKDAYSGCSESKRNDFKFQRVPHITKVAAVRASPFGAFAAIRRDLDVLKEQLVVSEQSLWRDVAPLNPLEGFRASEPKPQLRNKESVKFWENETLKSNLGSVAYEVLKSPDLEEDLESYLAEWNHVHQPLDALVCSSSLPDIRIPVHAWLLSARSSVIRHALAHSRRLSFDIQHEAFTISKVDGKPLLIFQGLDVIALLNLVHFMYEDKVIPAWNFTRQAPPLAYRYRQIRQEVMRLATRLNMHNLEAAARLQVDPKKYMDEDFRVAIKDRTFFGDGDILLELDGQEVAVHSSFVCQRCPWFQVLFHGRSRGIWLATRREEAEMENERIKIDLKHMDPGAFDYVLRYLYGDYGAELFDPTVCDTFADFLDLVMEVMSIANYLMLDRLSQICQTIMGRFANIRNIANFLNAISPCSITEFRDAGLEYICLQLESMLENHLLDELDDDLLLELDAIVRDNQAAQSPFVRSGRSEMLLHEAHPELAQDIDEERQIRVKEIAFRATREDDRKLSTSFRGKGGSGVDDASAFTPAADKTKKVPKIARNEPFGLSPELKPKTSQADLIFDMEEDGPAAVGTPLNAKAPKHSTPAAGMDQFPSLGSSWKGKAPIRRGQPPAVASPSSLQAGTSPATKTGGAPWANAPMPASKVGLRDIIQLEATSTPVAAGRSALSEGLAAQQQQQTGKEGTLAPKVAQPKLSQKEKKKQQQEQAAAQAALHFAKASLANKPAWGDTESKAPPPWKMVTANKAKPAPLDVNPPVSSSSVAKPLVAAETTPVARRTASPDTRFSGQRTSSNNSVHTANPNPKSKYTPTPSSSSAPRPSPQPPAQQFPSLGESSSKPIVPHSKVYIAPARKDEHLLGFSMEEIILQQKLEQERIKGATSKRSLQEIQEEQAFQEWWDAESKRLQEEEEERKRKATEKEEKKEKGSKPRGKGRGRDNVNAAESSKAGGDVTTKGAGKSGGGEAKAGERKGEGRGGRGKGGPGGKKDGPAPGEGKGAVAAATSTSATPAIPTGPKGHGGAAAPQQHPRKADGGEGSSNPRRRDRGRDRGRGGRDATQVAGAGSTPTGPAIPAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCQ0</accession>
    <name>A0AAE0JCQ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_575543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680186.1">
        <property type="nucleotide sequence ID" value="XM_062830623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCQ0"/>
    <dbReference type="GeneID" id="87867777"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="957" mass="109572" checksum="7A1C7116BFCD68AF" modified="2024-05-29" version="1">MDVPIKEEEPSTAEAISSNVVGHGKSLPYAWDSCSKELLRSRIFIKQQAVEDAFDRAKFICEAISSALEDKESETFKELFDEEIAAWMDEILKLEKTHKDFEVLVGVAGVTGAGKSTILNTLLEMPELLPSSNSEASTSSACRVSWNYDNDPKHRFTAVVAFREREDVQRELEQIYEALDECREMEEGSDGEDGEEWFEQKAEHENTIKEGMQKILAVWGKEREEVQMLSAEDLLASNEDVLSVLGTTKRLHAADKEEFAELVKPYLDSSATTEGYQAWPLVKEARIFVKADILRHGIALVDLPGLSDAVESRAQVAERYNQRIDTTIIVTPSVRAIDEKTAFQLMGKYQALRMKLDGKLHKNRSCIVASQMDGIDHDVFSRSSPEARNKAGLKEDLESMKSLTKRLTVLDQRIKDCRKKLVEFNNRKEKAIIDRDALKPTLVDKRYQERMKTARNKVTTTTKLVRNQESVLNGLQQERYSANLSLRTCEGRAKWTCMSMRHSRIEKRLTENFERQRKELEGTSQRLSSSEPTTNIFSVSATAYRDLLKGRKVAGFPTKSYTGIPQLSQWLCDSVMENREVHLDSLLNALRRLAHGIQRWSNKLEAELHLWSEKIKSFDPFAQIHQTQTVCRREAGRVATRWAARNPNDMTSSVFMAWMTFNAILKRGGGPYKFKSKTGESHEYNFPEALVIPILEKVVLKTWHKVFHVKIPAAEKPIIPRVDAIWDQYWRSSLARSKKLHPNFSPMSWNASRPCAASKTRYVTRFTRHLTKLSKCSAEIHPEFRTTMEEKLKPMFDECLEIKGKGHYQARRKYLQDNVKAKNTKMFNDGFKKMKRRYETHLAKVPQEFSAIAQFAVTKVQEQIGLLLTNIETVNDKSQKLSDRATTLRQEVGQAAMQWVVEWRVPKYEASPARPHSLLLPRKYVEPEPEELDEEGNAAKGKQKADDDGDVEMEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDF4</accession>
    <name>A0AAE0JDF4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_527732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680937.1">
        <property type="nucleotide sequence ID" value="XM_062828879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDF4"/>
    <dbReference type="GeneID" id="87866033"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36554" checksum="003AFA9D04557671" modified="2024-05-29" version="1">MDNINFPAQPPNSPAESLGSISSEDAPSGDLVFLVGPAQEEILADLTGLREASSVFAEILAPYAMEMQGISYPGSGSGSGSGSPLPREISLPDDNDFAMKAIFYALAFPGEFIRPATPANPAPAGPSAREFLHLAVAIKKYKLQDNLFVPWARWFAEVVDKVKANGGTAQEMVWLVAAAWQLGERRRFAELGLDLMVKHQGRAGSFARLWAGDVVVLRVLPENFPLVGERAAQLKMRVLDLVRHRVADDGCGCGERAELTSSWEDVWEEHGWGSTVPLSELLRAVEPLAEQEAASVGEECDCGERELGPGAVKKELEKAKREAKICFECVEMGGAHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDL0</accession>
    <name>A0AAE0JDL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_577112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680985.1">
        <property type="nucleotide sequence ID" value="XM_062830680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDL0"/>
    <dbReference type="GeneID" id="87867834"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="286" mass="31871" checksum="4734F11289A628A1" modified="2024-05-29" version="1">MHPSELLYPGDRALFTFTERPPHSTKQSRWYFGISSHTSDGHTPDLHNPFHPDHQWIIYECIPVQTDQTSSQPAQPLTSFAVHRPINDDRPLSTLNVLLPSSQPPFLGAVTTQIIRDQWQASFHLLCHLDDKLWFWVRDNLVHHFLTGKSIEAEDGIVKDGQDFVKIVLAEGMRDEGIISDEEFDEWWESVYCYYKEYREVKGFEVGRVREREEGVGGDGAGNGVGQRSGERMPGRLGPEGVVVSPVPMILPMPTPRRSGGRVGSGRGRERGGGGEDGVPGSSDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDV3</accession>
    <name>A0AAE0JDV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_235584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680771.1">
        <property type="nucleotide sequence ID" value="XM_062822257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDV3"/>
    <dbReference type="GeneID" id="87859411"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="2">
        <location>
            <begin position="97"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="303" mass="33319" checksum="15E1CD80B48A3165" modified="2024-05-29" version="1">MAAADTMLPQASSSSPSRSASSSVSSNQNKRRHLSDGDIPGNSNKKQRTTGTSNIQQTTSLQSNHQHQSNTTAGVVTPAFQPYESLLAKLRPRYEVKTMSVMPSTSIAKHVDKALQHLDRFNLWDQSVLPGVVLLSAKPVASSKLVTIAELVRRRIGEGEQKWFQYNVLTETEEEEVVDAGAGAGAGGMEVVEDTVMDLTKDGDDDDGEEEEAFETMGGHHNNSNQRQEQQHGGGGGGRGPHHQQQTVFERAIEPPKIRHNKYVSVFLSRIPIEELRTMRNIAVQSNEQHIEHLKKKRVGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE75</accession>
    <name>A0AAE0JE75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_426237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681249.1">
        <property type="nucleotide sequence ID" value="XM_062824621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE75"/>
    <dbReference type="GeneID" id="87861775"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="268" mass="31226" checksum="9FD01A897D62FDA8" modified="2024-05-29" version="1">MEQNPEERPFGPCKAPFVHNRWDKYQMFSTEAGEKPQPQIFGVNDERRVLAGLLVWPPTRVAPGENMVLAAMVKISPPPHPNWIKTVCRMIAFPTRKNPEDKFDKKAEICLATQDIGWRKPGNFEDFRELDFLHFKFENVAFPRAGEFEVRFEVNVTEYLDAGENPIVDWPPEHLWPSEAHMEIRLGTSRDLYKETGFCAGILVVGQQTHVREEYKGKWFDHQLEKEEHGDLPEGQDEELWVRLGESEYIKDLQEEATKKVLDNEGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEJ5</accession>
    <name>A0AAE0JEJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_186528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681429.1">
        <property type="nucleotide sequence ID" value="XM_062821577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEJ5"/>
    <dbReference type="GeneID" id="87858731"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43166" checksum="22F23361BE8A1DEE" modified="2024-05-29" version="1">MPTRSSIPATPRIISPSPTPSERDALEYTGPMTRAARRRLATPLPVSEEGNEEDDVPGRRRARTRSRSPVETRPTAGRRTSKKRTTKIADANTTSTDSTTAAPNEDMAVSEKQAKEVSNGHLLPPQPAGYTGWGWKDISRSPSPLGLIPIHRHWRAFIHRHEVPRKALHVSIGFFVVWLYLSGTQTLSVCPYLMGALIPIAAVDVLRHHNASFNRFYVKVLGALMRESEFTGYNGVIFYLLGAWIVLGFFPKDVGVVGTLLLSWCDTAASTFGRLYGRYTPRIRSGKSLAGSLAAFLVGVGTSAFFWGWLVPTKGPMPGDELFMFTGTLRLPQLLSEAVGLTPAQATISGGLALGVMSIWSGFVAAASEVANVCGLDDNLTIPVLSGLGIWGFLKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEK0</accession>
    <name>A0AAE0JEK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase acuF-like C2H2 type zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_471021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681146.1">
        <property type="nucleotide sequence ID" value="XM_062827072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEK0"/>
    <dbReference type="GeneID" id="87864226"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase acuF-like C2H2 type zinc-finger" evidence="2">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3343353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="581" mass="64951" checksum="C5F8B9459FE6A1D9" modified="2024-05-29" version="1">MTTQVPISSLSAQGISALKALVETLEEEREADPDTRSLVSSLLTRFKLWVGNLGAHRASGTRSLKYKLRDASMLRNHVVSLLQDLCVSIDEAFAVALAGDTRGDGIESDGDRDSLDEELEKLWTDEGQDPDDRSDLDLALSGIQNAVDCLLRLSATIRNPAPHDHFKSRAAAEYGGMFELVDKNHISEKYTHLDQVVVERLAKSMARRRQYFRYREEHASRIAHGVEDIVEGVECGDVSEYTANQTTISSLPGHSKDEALAATVAEMDAFDDLDDAQSQASETSYAATDVNSTELRVPRPPPEYIHGPFKCPFCHMIITIENKHQWKKHVFRDLQPYNCLYNSCRMPHQQFSRRSQWIEHMKREHWRVWHCSLGCASATFDSAKQLIDHNKSAHAANLQSSSSDEDGAMALSSVPDISKARGPCPLCLEVTIATDKIYGKHVGDHLERLALFVLPRVDYEDASDDDDFQDDSNDDDDDNDASDGEIDNDGQPTASNEVKPRDSSNTSSQQPRQPDGPHEPQQADKRMDWESYLHRQTGLPGDDLDNDMYAESSSQQPPTKPGIVSRNRTRDPDAPPTYSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEW2</accession>
    <name>A0AAE0JEW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_550369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680992.1">
        <property type="nucleotide sequence ID" value="XM_062829729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEW2"/>
    <dbReference type="GeneID" id="87866883"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042005045" description="Cytochrome c oxidase assembly protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3343199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12581" checksum="E0598434D5D220E9" modified="2024-05-29" version="1">MSRASKLTLLGTSAFALSTVVFVHWQQQSEKEAMHAGVIRDMEQQRIKRERQLDFDMQRELEAEYKKLQSVRDVTDEMDPVPSKPSALTQGLPKPSAVPSIPVGGAIGTGTGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFA3</accession>
    <name>A0AAE0JFA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_192547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681628.1">
        <property type="nucleotide sequence ID" value="XM_062821664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFA3"/>
    <dbReference type="GeneID" id="87858818"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="204"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3345015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="469" mass="50802" checksum="97ABE6137F9DD217" modified="2024-05-29" version="1">MADSTHNNESTSTTPSPDQDRQITPENDPRHFHRRPMPATVEDAPEEEPQPDRSAAATETESQQPTEATTSNTETPNANENNDFNDARPQTEANGTSTTTQTSDEANTEAPRSGSRPTNTQHFEIRFIFPPVTFFTTVISEPLAPQSQQQPAGSQPNGQAQSTEQSNEQPNNQQSNASNSSTNGSTPNSSTASGPPPITFFGLHFFTPTPPHVHTAPASNATTNTTQTEGTAQQQPQSNGEQPQASEQQQPQQGPQPATQGQPSPFGSGPVPPGLMNAFLSAILSPFGNLNFVNDGVYSQEAFDRIITQLREQHAAQNPGGAPPASQAAIEKLRVKDIDEQMLQGCQDNKTKCVICVDDMTLGDKATLLPCNHFFHGECVTPWLKVHNTCPVCRRSVEVEEAPESKKRKNMAEHEPTGRDGHGIDEAAEDEDGQQSAATATPAIPERQRRPYGPERLRGEGVPKRRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFD7</accession>
    <name>A0AAE0JFD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_508512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681262.1">
        <property type="nucleotide sequence ID" value="XM_062828229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFD7"/>
    <dbReference type="GeneID" id="87865383"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="357" mass="38672" checksum="A36C8E0E84182817" modified="2024-05-29" version="1">MPGPRSTSHIKQYTPSQFSAAIAAVSSGSLSIRKAAQAHSIPFSTLQRHFQGTPQAKRSYETSSREMQKLTPEQEENIAMWVLAQENLGLPVKMEDIRRFADRVLEVGLKEGAQGQGQGQSQKKGGVRTALVRKGTAEKEKEKGVNKEGQGEGEGQEGEGLGSGSVTVGKHWGPKFMQRHPQLKAAREARRKELKKGLRGKQAGSAASASAAASASAASAAVVNTPTPVAAANGANGHGHTAPGSAAQAQARFAPPPQTPTPTPAATSAPAVQQQQKNSRQRQQQEEEDVDPELMEQDQDQIVMMEEDDDVEEDEEEEDDNVQVKDEEEYEDEQTPDQQLLMDSQRYSRFATNNGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGC0</accession>
    <name>A0AAE0JGC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_209841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682213.1">
        <property type="nucleotide sequence ID" value="XM_062821918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGC0"/>
    <dbReference type="GeneID" id="87859072"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3345600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="495" mass="54591" checksum="5BF4B9F33CCAD351" modified="2024-05-29" version="1">MGDPEKEVALHHEQAPKDAASSNTSLPELSWTDAEETAIRRKIDWHCVPIVTVLYMLCFLDRVNIGNARIQGLATDLHLEGTQFNWALSIFYIIYLLFEVPSNVLLKAIGPRFYLPLLVCGFGLVSLCTAFVTNFGGLMAARAILGVFEGGAMPGMAFFLSTFYKPEELLFRIGIYVSASSIAGAFGGLLATGLAKIPEWGVAGHTIHTWKNIFFFEGIITILIGLAAPIWMPTDPKTAWFLDEREKRIAAERLVREHRADPAEKVQWRHVKLAVMNVHNYTCAIGFFLINITVQGLSVFLPTILKDLGWQNTKAQLYSVPPYVCACLVAVAVAYGSDKSRQRGIWLAAFSVLALIGFAILRWVSQPNIRYMAVFFVTVGAFPGGPGFLSWAINNSAGPAVRAVTSGYVVTLGTIGGIVATWTYVPSDAPKYHTGHTINLGGQIAVVCLSIFGILYCAWENRARAAGKRDHRLEGLTEEEQEQLGNRHPRFHLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGG1</accession>
    <name>A0AAE0JGG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_426410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682298.1">
        <property type="nucleotide sequence ID" value="XM_062824630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861784"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1105"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1200"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1293"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1383"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1740"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1844"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2273"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1139"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1204"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1219"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1245"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1425"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1458"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1484"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1538"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1548"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1844"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1873"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1906"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2035"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2293"/>
            <end position="2306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3345685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2384" mass="267757" checksum="62D44499BD58943C" modified="2024-05-29" version="1">MSLSKPSKEPTPPPTPPSEPQATDIPLPESPLVLPPAGSPFWTTVAAQEIHHLGDIIDDKIQDNPNSVSDVDNTTNSMQESSTEERSLTPPAEAREDHQLVDLGDKNTDDKPTAMDDVDNTTTNSKRNSMSTSQDQERRSLTPPLDQVMNEPSEPEPEPEALRTLPKAKIPDMLAQLSQRITDLEAAEDAQNNGTCSTSRLLETQQRLRDATSSLLLDALAVASVVMAEEGGEDTEASVASVNPALVPLPSDDVNEDGLESGPEEYIEDFLLPSLASRAGDYLETVHYEDGNHEEEALQYPGPTGIQVPFPPSLSEYDVELELEEQNSPSLVPTFIADNLKAQNKDHQHLPDIIPTCTSYDDMDWSDLLPARAAPEDSSQATSSDSKSSLAVQLDPADVPLPEDDPFDVPLALHGHDDGSGLPDYSDLEALGDHGEIGDHGDLVLGDDESDSSQLFVDDGSPLPHWRTFLVTTSSEDKLEASPEEAQVKSDAHADVEADAGNAADAADDKQAECLLQEMVTGEKRPSKEEKGKGKAEQQDHDNHDSHPSSSISPCAQVVPPALNLSQQIVNTEYEAQQQQQQQEPEQMVSVSPRSPQVSPYSPAAMAPVALLAPPIAPVAPMGSILPDQHMGTDQLPPPQPVVVPELQQPEAAPCPGGGTQGQPTTPPTATVYVDVDKATEHEPKDDRYSPLPASSSPLLSRSSPYRVSKSSQPQPRESLLHSVPYTPAVVPWDEQRDLRLLPPLPEPERLPTYTRISKTTDNSRVMPMWFEGFSAQEWFLIEPAANLFYRRIRHHWHPYLPQWPPYIIGPTPLIMELSQIGKDGLAGEINILLHCERYSPPGFMPCQQLRSFTKFIRDCLSLQNIRDITVPDFQTVHECKTWLETVTKNGRMLSFMALHCHVERLRSGVSPGTHEFLDAIRDMGCQLGWNEGVYFSKTSVLQEFKHVPRYDSSSTPFISLRGNPNQQNLVNPGQHFDYGQGKSTDYCIALRADHPYLNIRVTLAALNTLSFEWPQWVGPPDAWVKSWDPCDEEVVGPPRRVRLAEIRVRRKDLYDEYVALKGRVDGWFENHPEPPRTALVAGGMGSRSCACRHCRYVTSHQHHHDGESECECDDETPSSSGNSSPRRTRSGFDGLQPFPRPRPLPEPPRPGFSSLADADGESILTKEELASVRRAERMVDKLDRNIDKGLLALNPLKRRKTGASAEQAEATNAEAENVDEKAAEPDTRTDAQKERQRRRNRKKKEQEKEAKKKKAARSEVVAESKAQIYESLKTGGFNREAIKDVLNETMAKIGPKSGAPEDESRGQVLANKDGLSPEEEARFRDSVKPLYAEHLRRKEAGDSTKLFGKFEIPADISEEDFFEAFLNNVVVVETNDKDGFAIDWKPDAEEGTQSQEALVDSKGGRCVPEEAQQSALDNQLGHASTEHSSVKEQEAPAEAVKPQPKDVHSTAGPSTHDVPDHDTSDVAQPKELDDIASADVSQPAAEPSTGPEAAPEAAPTVLPTDIPASPRDTPNHDATSTPNPPPLDKSKEASKAKKERRKLRKRLDREKEEARLREQAAAREELRRQAEARHQAELDRKVGEAQRKLDEEKARRLEQHQKEEAARLQRLKEEEARLQKVKEEEARRREEEEVRKRDEEQRLAEEEKKRQEEELRKEEERKKEEERIAEEKKRKFEEEARLQAEKEWYAMQEQKKLEEAVREEEARRLALEAKQNAELEARQKAELEAIRLAEVEAKLKAEEERKAEQKRKAAEAKRKADEAKKAAEEVKKKAEEARQKAEEDTRRKKEEEAKRIAEEKKRQAEAKRLAEEKRKAEAARQAEAKQQRQAELKQQVELERLAEEKRKADEEKGKADEAARQAEAAFQGELQRQAHEAERKAHEAAQKAKAAVQAELQQDAKKRKAAEAKKRAAEAKKKAVEEVERRRQADLEAAARRAQEEQQRRAREEAERLKREAQAVRKAEEEAIRRAMEEARVRREEEARIRREKEEAERLKREAEKLKKEVEEARERAEREEARKKAAEEVKRRKKAQRKAEAEAKRKTEAEAARVKAEGEEKLRQMLGIQQVDNSLTLAEQKATPFHEQQILLQEAWHQIDESLLLSQQAHNSLLRAQHHNSEAFRQLGEADLLLSLSQDVSQDCQTPQDAPSLISARHRFDEAILQAQEGYRLLQEAWDYHDSSMRTAEEGHRLLVEVGHEGEHHRSAQQYSLVEARHHNDEAFRRAEEGRRGLEEAFARMGISLQQSDKDMHHPHADNHSQTSEQEPHTILITTPPTTHHQLSDPEAETEETETLSSSFDSMSTTTSGDLPGNPSDDRPYEERLAAFINDQLVTYGVWDPESFYVRYDPCNPRGPRAHEMLVASERGSHGDAAGSDVRGVKEAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGT3</accession>
    <name>A0AAE0JGT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_460912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682679.1">
        <property type="nucleotide sequence ID" value="XM_062826570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGT3"/>
    <dbReference type="GeneID" id="87863724"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF17">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G16630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="157"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="262"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="437" mass="47599" checksum="C3F3450112698D19" modified="2024-05-29" version="1">MADFFGSSAPFAEPLWYSRVGNPNYNDSHRRLRDEIRRYVDTEIEPFCSEWEANGAVPQQVLSRHSALGYTALLINPSETREYLGEIKLPGQVSPEEWDGFHDLIAIDEMARCGSLGVLWALGCGNAIGCPPIIHFGTAEQKTRWLPRVIRGDIRFCLGITEPEAGSDVANVSTTAERRDGVFVVSGTKQWVTNGLTADYCTAAVRTGGQGKSGISILVIPLHAEGVTRTPIQNSGVASSGCASLVFNNVEVPAANLIGAENEGFKLIMLSFNHERLWIAGNCLRLARVCLEDAYQHALSRRTFGRPLIDRQVIRLKIANVGMQIVAAYALLESLVQVRDSNFKRAAQSDEVLGTNIGGLCALAKVNAARATELAVRESQQIMGALGYTRGSGPGSRVERISRDVRVLVIGGGSEEVLCEMAVMQERKDLVKLQQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGZ7</accession>
    <name>A0AAE0JGZ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_146221</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682396.1">
        <property type="nucleotide sequence ID" value="XM_062821008.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87858162"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000560">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="373"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="541"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="611"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1446"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1521"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="650"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1468"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3347314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1553" mass="171451" checksum="FB5DBE1BA748F074" modified="2024-05-29" version="1">MASSQPTSSGPILDSLPNSNSQSQSNTEPSSSQPRANPSEAQAQAGPGPARQAALTKRPSHREAAQRMSRKLQRLRGDSNQPHSPTMELPDRLKDTGKEEDNEEDVLQPQGGMFMNMNQSIFGLIAAAGSTVDFHDRFEGQSSEDEDDVPNHMAMTIAGPGIKGTARNRETVGTGKSLSQIVVFNKPPASATADAGPSNTHRRRLSGHKLLQSVPGLSRLSSSHKSKKSKQHKGTAMADNKIEEEEDPDPSSPLPPPNEDENKAPGLAPPIEIVRAEGNGAPLMSRMLEARAEMAARPSFDLDRLSGEHRRDDAGGTGQLAKKLKDIFEFDTAEEVIEEYPCWLLQHVLLQGYMYITANHIAFYAHLPKKAHEIAKSGYLSKSGKRNPKYNRYWFRLKGDILSYYQDPKDHYFPAGQIDLRYGISASVNDKEKEGNYFSVTTHHRTYHFKADSAQSAKEWVKSLQRVIFRSHNDGDSVKISIPIKNILDIEETQMVEFADTCKIRVIDNDETYAIDEYFFSFFSFGKKAIQVLKVLVEDSSPEDSGANDAPKGMGGDGANGDNLGSPPTRTFTEGVKATLSPVSPIQIASPSSRASGDYFRSSFDATRPFSRRSFDASPGTAGYPGSPPRSLHGDGRRSFSKPRHEPHASTDSYAQSFDDPSQASLSALVTSGSSEDQSASQILRGSDVFHSPIFRRSASATRAATEGEGVAAPPIVRQHTAGLVRLQGLHHAATTGQIGDHTAEAEGGPSTPTLQSIATMGNYPLQRANAFMGYLDRQSRRMSNLLATESMGYVEKVSGMWKGGKKHYDQPALGRTEEEDVEDDPEERALSEARFQAHFALPETERLQAAYFGFIVRVLPLYGKIYISNRHFCFRSLLPGTRTKLILPLKDIETVDKEKGFRFGYSGLVVVIRGHEEIFFEFAKAENRDDCAITIIQSLDAARYLAESQEAEEAQAAEAERDALNQARNEEFPDHEIELPRQASGVSDAPTILFDDPKASFLNFKPSEPMRITCLTIGSRGDVQPYIALCKRLLEEGHHPKIVTHREFKDWIESHGIEFGPVEGDPSELMRICIENGTFTYAFLREANSKFRGWLDELLTSAWEACQGSDLLIESPSAMAGIHIAEALGIPYFRAFTMPWTRTRAYPHAFIMPGQKMGGAYNYITYVMFDNVFWKATAHQVNRWRNKYLGLPNTSLEKLQPNKVPFLYNFSPSVVPPPIDYSDWIRVTGYWFLDEGGDKWQPPKELTDFIAKARADEKKLVYIGFGSIIVSDPAKMTQEIIDAVLRADVRCILSKGWSDRSAAVDGVEKPNVADPTLPPEIIQIQSAPHDWLFQQVDAAAHHGGSGTTGASLRAGIPTIIRPFFGDQFFFAGRVEDLGVGIYLKKWGVQSFARALWEATHSSRMQTRAEVLGGQIRAENGVDTAIQAIYRDLDYARNLITLKRQKHQSRRNSVATPTPGAKPNAPADDQDQEAEEDDIDADDEEEESWTFVGGNEDDMTGSMSMSRSDLLSQTVANLRGVKVGKEPTLGSRVLSPPPTSPGAKRGTGGVKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH02</accession>
    <name>A0AAE0JH02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_460139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682411.1">
        <property type="nucleotide sequence ID" value="XM_062826514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH02"/>
    <dbReference type="GeneID" id="87863668"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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            <strain evidence="2">CBS 560.94</strain>
        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Ohm R.A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683159.1">
        <property type="nucleotide sequence ID" value="XM_062821285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHS2"/>
    <dbReference type="GeneID" id="87858439"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.60:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="92"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3348077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="202" mass="21923" checksum="D82C3EE1BE2AD5C0" modified="2024-05-29" version="1">MVTDNDPAQTGATATAPVDGTATEPPKKLPKGVVLGKDGKPCRSCTSFGAWASQAKATLKTNPDASSTAPSSTIASAATSSTTTLPQRRTDCPADVETLGRSTWTLLHSIAATYPPAPTPTEKNDLKSFMGLFAKLYPCWVCAEDFQQYIKKEEPKTGSRDEFGNWLCEAHNEVNRKLGKPTFDCSKWQERWRTGWKDGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHZ1</accession>
    <name>A0AAE0JHZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_424359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682906.1">
        <property type="nucleotide sequence ID" value="XM_062824506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861660"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1287" mass="135061" checksum="6147A9798D26036A" modified="2024-05-29" version="1">MATTHREHLPGAYPDSNPATPNEQGQAAPLNQSYIQGHDQRNKLHKSTNPRSHNFSDSRLGSIESQPIENESEISQRHFYGNSSGEAVGGGFYNHGNDPTMSNSQHPRVSQVPQRTLPMEDTDREAAFGDQHEYTFSKPVPTDARQAPEQGFRQVDSRPEVDSHPDVATSSQGADEQLSNIGDKSSNDDATSRTSHTSGAAPYWGDLPKASQGGIYNTVTGHGSARDDHDEHHHLPQNSQRSAEDSDSRLHITGLGTDVPSGGVYNTVAGHGSNDEESRRHLEDSNNNNNNLKVNIPEPGHVGAPTIKSTDAVLDAPLAAVPEDKTLASDSFSQVPTTSAGSNAQNSDVKAQRAFPLAAKHATTADVAMAKDDAASSPNQHPLRHKDAFVAGAAGLGAGAAASHLAKKHQDDELRHIKDRDTHPSGAAAVSHRRKSQELNEAGVIPISGSTLEKMKAKEEEKPLGEDTLDVWDITPENLQKPATRHTAHDANVQKPAAEHRLAKEPSPAESRRSEDSSSKGEKKHRGLLGIFHRHKDDKEEHTTTTEPPKSPKDKGHNKLAKKDAALAGTGAAAGYGLAHHHKKDDKDAANQNQRKSFSGPSANQPTELDQKRRASEAAPISHRRNASDPQSSIPPVPAVGVVSTGAPSHGISQAQREHAPASKIPVAADHSTQDRLNSNTARAGMAGATLAGVAGGIGAAKYASAQDDKETVHPKQDVSHVASGVGAPAAAGTGPVTSGGLYHTEKPRQAPADLEHPRHAPSPPTQHAADFSANPSGVKPNEKLARNTAQEPGYNILMSGTPSGAQPMSTHVHGGKHAKTANEPGNYNKLASGTPSGPGDYNHLNTGTPSGVAMNTANVGRARSEDQPRTAQQPGNHKHLATGTPSGVIAGATSQPSARRASEGVKRNAPAAGRNDSEEGPYNVLASGTPSGVKISPHHSRHGSRSTGPAEMTEPVTHADSQDKDGIYRTLASGTATGVNVAAMHENRDKAKDDIKDEIHEQSTMNTPSAKAGANQRGLPPAESQPIAALPPAESQPIAALPPAESQSGHSAILLPAPEHHQNQNQNQVADLSATPTQRRTQDQYKPVLSAEPPQHFMSPEVMPDAYTTSVPGRNSGAGSGPAVAPASTEPMCAKHMSPNVMPDAYTASAPGHSGAEKLNSIPESTTGRAYPAAAQPEGVKHMSPEEMPSAYTTSAPGHSGAEKLAEPETMAPRSAINPALAAASGAWAASNVGSGQKGLNESASGKQQRIHKPVLHKCQHCGKDNDVSGVLETALKGESESGRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ28</accession>
    <name>A0AAE0JJ28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_463552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683576.1">
        <property type="nucleotide sequence ID" value="XM_062826710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ28"/>
    <dbReference type="GeneID" id="87863864"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="191" mass="21793" checksum="602C9382F1CC1040" modified="2024-05-29" version="1">MLNIDDTRRAVTVTTLNWKFFPAAPLEKSRAGTYDLGIAYEVPPDYLQSTEGRSIAALQRRHLQRVLDKLTGTLGWRIEEWVGADTTVIRGINLINVKVTKRAESSGKARIVAYKLHFKSSTEAHALVDLVGFGSWHTSPTEDYCIKMPNSIRDDTEEWHEYVRTTRDRKIASVEKTNHPGLTLRRRVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJB0</accession>
    <name>A0AAE0JJB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_419952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683924.1">
        <property type="nucleotide sequence ID" value="XM_062824246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJB0"/>
    <dbReference type="GeneID" id="87861400"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000051">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="441"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="534"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="77746" checksum="662029DC4507F84B" modified="2024-05-29" version="1">MSLPSTYRRSESSMLEHQTWCDRGFEPTETSLANMMKARGLVQKFKVTHLLSYLGRLNPIPIGVSKNDAVWLFDNVAFRGPNGTWQAEFVTAVFDARVSTKFVEAVGDIAEKVGLSKGDKQEKTIEQRITPFLMEVLPGRRVDIKFGESTELRLGPGGRNGISSELKKLPDLAAGTVVKSVAEVPSGAGGLLEMNTFYTEPEGWAVISDVDDTIKITQTSDPVGILRSTFVAEPTPIAGMPELYWQIKDIVTPSAPWFYLSASPYNLYPFLRDFTHRYYPRGQLILRDASWMTIPGLLSNLTLGTQKYKVDRMKKLYEWLPKKKMICVGDSTQSDPEAYGEMYRKHPEWIKLIIIRKVTDIAAIGTETKNAPKRFEEAFKGVPREVWHVFEDPAECREQIQRRVSFTTTTIATALSTAAERFKMSSEGAAAKRQRSNKDVPYNLIYWPDIPGRGEFIRLALEEAGAEYVDTAKVEGGIDEVMAHIKGEKPDDNTNPPIFAPPILKHGDLVISQTPNILLYLGPRLGLVPSAADDPDALYKVNELALTALDGLSNEPHDCHHPIASELYYEDQQEEAKRKAEHYVKTRLPKFLGYFERVLNSKASGEGPYLYAGKLSYADLVLFQCLDGLKFMFPKAMAKLDKEGKHSKLFELYDAVRQRPKIKEYLEGPRRQKYSSGLYRYYEEFDIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJD1</accession>
    <name>A0AAE0JJD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_455841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684060.1">
        <property type="nucleotide sequence ID" value="XM_062826258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJD1"/>
    <dbReference type="GeneID" id="87863412"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="81"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="519" mass="57216" checksum="A931167C2C8301E4" modified="2024-05-29" version="1">MTEPTAHPKANRSSSPSLGDSAKVVDIENVEHAKTSSSHDHPDHHHGQRAALQPPPWIAALSPEERHSLEKKLKRKIDLRLMPAIIIMYILNYIDRNNIAAAKLANLERDLNLSSVEYQTSVSILFVGYLLMQIPSNLFLNKLGKPAIYLPCCMIIWGTISAATSACTSAAGLYAVRFFLGFVEAAYFPGCLYYLSCWYTRSELGLRTAILYSGALISGAFSGLISAGVVSGLDGAKGYSAWQWLFIIEGAATIVIAFACFFVLPNFPRTTSWLTEEERTLAVWRLEEDVGVDDWVGRKQQTFWQGAKMAFVDFRTYVLMVLLFCIVASGTVTNFFPTVVNTLGYNRIHSLLLTAPPYVLAVIVTFANAWHADKTGERYFHIAIPMCVAIVAYIIAAATTHVAPRYLSMMLMVPSVYSGFVVALAWISNTMPRPPAKRAAALAFINAVSNCSSIYASYLYPNSAAPHYTVAMVVNCVTAFIAVCAATVMRIILSRQNKKLARGEWVEGAINVEGFRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJK8</accession>
    <name>A0AAE0JJK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase spb-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_100664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684147.1">
        <property type="nucleotide sequence ID" value="XM_062820436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJK8"/>
    <dbReference type="GeneID" id="87857590"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="621"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="790"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3350852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="834" mass="94256" checksum="7C2DCD140ED920DE" modified="2024-05-29" version="1">MAIQKKHGKGRLDKWYKLAKEKGYRARAAFKLIQLNKKYGFLEKSKVALDLCAAPGSWCQVCAETMPTNSIIIGVDLAPIKPIPKVITFQSDITTEKCRATIRTHLKTWKADVVLHDGAPNVGTAWVQDSYNQAELALHSLKLATEFLVEGGTFVTKVFRSKDYNSLLWVCNQLFAKVEATKPPSSRNVSAEIFVVCRGFKAPKRIDPKLLDPRSVFEDVAGPAPNNEAKVYNPEIKKRKREGYEEGEYIQFKEISASEFINTVDPIAILGQYNKLSFEQPKNGDVALAALDKLPETTEEIRLCCADLKVLGRKEFKLLLKWRLKVREIFGFPSKKTQKAAVDEEVATVENMDEELRIQEELQRIKEKEGSKKKRERRRENEKKQKEIVRMQMNMTAPMDIGMEQEGPRGEGAMFRLKTIDQNAALNKIAKGKMAIIKEAEKTKDYDFGSDGETDESDEEADRLEEELDNLYDQYRERKAAADAKYRAKKARKENGDDEWEGVSGDEKAGSDEDDDEELEVDSSDDDSDSEDGESGKKLITDLDGQPEEKDGLSKRAKNFFSQGIFAEIPGLLEEPESEEEAQEAELVEAVEELKVTKKEKKEKKEAKETKAKSKKAAEESDGEDDFEVVKNNEDDDWENVEKKKKNGRPDIDIITAEAMTLAHQLATGEKTSYDVIDDGYTKHAFKDRDGLPDWFLDDESKHDKPHKPITKAAAQAIKDKLRAYNARPIKKVAEAKARKKFKQAQRLEKLKKKADMLAGDDGMSEKEKAASISKLMAGVAKKTRRAPIKVVKAAGSNRGLQGRPKGVKGRYKMVDPRMKKELRAMKRISNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJZ6</accession>
    <name>A0AAE0JJZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_455501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683956.1">
        <property type="nucleotide sequence ID" value="XM_062826238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJZ6"/>
    <dbReference type="GeneID" id="87863392"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="180"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="386" mass="44753" checksum="E2989FDA9F76DA09" modified="2024-05-29" version="1">MASNGVVAPVASSQAQVVVDEQQQPDQQLTAQISKLEIAEEKQQQPEQHQQEEQQAPANGEQAPPHRSHDPQFNQKRSDPFQFGSRYLQEQDDVFEFNAWDHVETDDTYNEYAEQQYEMQRNAPVSDFDKHRFNSDPAKWWNQFYKNNTANFFKDRKWLQQEFPILDKVTSEGYGPCTLLEIGAGAGNTAFPILSKNKNPELKLHACDFSKKAVEVMRSQEAYNTDQMQADVWDVAGDELPPHLEENSVDVALMVFIFSALSPLQWKKAVENVYRVLKPGGEVCFRDYGRGDLAQVRFKKGRYLDENFYIRGDGTRVYFFERDELADIWSGKLFTQDSEVEDASEPDIRFVIEDLGVDRRLLVNRAKKLKMYRCWLQGRFRKPLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK25</accession>
    <name>A0AAE0JK25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_440044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684400.1">
        <property type="nucleotide sequence ID" value="XM_062825457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK25"/>
    <dbReference type="GeneID" id="87862611"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="498" mass="56545" checksum="5BECF513F7B88F25" modified="2024-05-29" version="1">MDTQPPSSKAYLARMPLEVLTRITYFVRTPDLCNARLTCKWLESALFHSFAYEFFRKKQFMVYGPSLQVLVDISKHPSLSPYLKHVIIGADQILPPHRILSGHDDKESLNWHLAYADQQTLLASGRARDMLVEAFKNLLNLETVDLRDFHSSSRTRDGNATWSSYGYNTLLETTGVKHFTGQPRAGEEDYPTRLFVLITHALAAAKARPEGIEVVIRENWAVRDHGFLVPTYLEPDFLPVLAGLKKLHLVLDINQATHGDVEIQYLLFKRFLAHTPNLTWLRINFRRQISHYGEEEALLKWLASSLRPGTWSSPGLINADPSRLPPPVELDHLEQLDIGQVSVSANTLSRLFRKFSPTLKAISLRRVKMQQNSDQQTFDKDDDEQNPWIKFLRSLKKESLPHLRELNLSFLEAVVRSNTSGATLDYPVVGFVNPDEAEKQNGISATGYQNLQGMVQVIRDRTYTGLKLETFLSNPAADIATPSKHIEGVARLKIPNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK34</accession>
    <name>A0AAE0JK34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_110943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684510.1">
        <property type="nucleotide sequence ID" value="XM_062820575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK34"/>
    <dbReference type="GeneID" id="87857729"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02670">
        <property type="entry name" value="Peptidase_C19N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="134"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="781"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="821"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="864" mass="96555" checksum="BB38ECB8AC8BC451" modified="2024-05-29" version="1">MEKLKGTKTTSLVPKKFRSVREKNGTHSRNKSTEPGPKSRPLGDMTWLSFLRPESAKQALREKEEVEKEAAKIAEITKQLEELNYTEISEQGVRFSLNSKFANGDLNKAIELIRLQQKAVAGIIQPYNPNISMQGAENRGNVTCYLDALLFAMFAKLSAFECMLKNDPADENQRRLAALLRLWVNMLRSGMLIHTDMTQLIQESLAACGWEEAQDLEQQDTSEAFAFITETLQLPLLALQVDLFHQGKKDEDDHKVVHERLLNLAVPPDPDGKGIKLEDCLEEYFNNKVDVFRDSVEEKKGDDEKGPLPRETVRLISEDEDGQASDQGDNSPHLQRRWTTQDSTTRTPVSMLDVTSARPELPAAPRHRSTSIIQRIVVEDRKPPLDAENETLLQKAKRTSSTVVKAVTIPAWQFFRLIPWHATASNGEPSNDVEVARHFNQRPVVGICLKRYTMTETGFPIRQNTLIDIPDSMRLPHFMMPDDDEKQSNGLSQEYKLVLQSVVCHRGDSLHSGHYVSFARVAPKLLTDNRRYEHDPPPDYEEAQWVKFDDLDLDNRVSYVDDIRDSLRQEMPYLLFYQIVPMVDVTTASSDGSVGEPPSYNESTTVITGVPGTPSMEPLPERPGGMSRSISDYFDSASTLVHNGGGPNIRFSTELERPARLSLDDDPYGTGSAGHLRAGRSRRGSLAVSDTTATTAITPSDVGAPSMLPTTPQEESTATRLGRAAAKFKSKSRPVSQAGETRISLTMSRWGLARPSRDTLNKDAANGAGNSSEGGSDEQQPDAKEVEDASDKDQKEKNKDKEKEKEGHHHLHHYRKSKKDKGRDKEDTKEKGKDKEGKKEKGDKSGKNKETGKDGVPDRECAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKC7</accession>
    <name>A0AAE0JKC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chalcone-flavanone isomerase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_421290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684552.1">
        <property type="nucleotide sequence ID" value="XM_062824333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKC7"/>
    <dbReference type="GeneID" id="87861487"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="222"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="444" mass="48533" checksum="751D09D8E5E7EC13" modified="2024-05-29" version="1">MSISSSGYGARTSITELKASRPQHEVFRNCKRSCAALGHEVNQTAPKLRQFTTTMLRQSTFKQLLRSLGSAAKAATRTPASRRTFLSPPRSQPNEHLNRLDVNKLSEQQIKYARNRRAFLWTGLFCSVSSMIYAGYLIKLELENSPVQADSSLPSTDPLAGTNAAERKVVVRDEEGHELVPTGNSTVPTFPRTLELGSFEGAIAPGASASGLATTITGADKTEYTLVGFGLRTVTFVGIQVYVVGFYVATADVASLQSALTKKVNPIATTLVPGERDQLRTDLLDPAKGEELWDGLLANGIPARSVFRVIPVRDTDFHHLRDGFVRAIQARAGKVEDEQFGEAMKHFRQIFNRGKVPAKKELLLIRDGEGKLIVVYDDGGNKKEGRPAGRQLVGIVDDERVSRALWLNYLAGKKVASEPARKSIVEGIMEFVERPVGTVAAQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKE8</accession>
    <name>A0AAE0JKE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme oxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_567686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684181.1">
        <property type="nucleotide sequence ID" value="XM_062830374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKE8"/>
    <dbReference type="GeneID" id="87867528"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="93934" checksum="0F3553F0315CCA24" modified="2024-05-29" version="1">MERSSPAPQYSHLGDQINAATRSVHTQLNSQIIRRLPLALPPAANTPSTYVSGLLHVAPVYITFETLWYMILLSHKEQTKDFRNPSPYQNRPPSPQPPQEKDRFLLDPKTSHRVPFHDGGDAGLSQRPGTSERIFSILESLRLPGLMRADCLRADIRCLTGWSKDVVDEQIEVAAQNGNLKKFITHIKQSVGESPHVLLAYAWVLYMALFSGGRILRSSLEKAGPEFWKTKCDPIMPLNKACAYPDKSHATAPMSERLRFFHFSTNQDGEDLKREFKRRLVEAEDLLTTSERARIVHEAVHVFENMLALVSQLDHVFLEGTRDDSVLDINVTRTDADADSPSPSPGPSSFKPLEQGGRIRDSIMLSKERGVRTAPGMRNHRRSRSVSIDEPLDERGDRSDVPSPYLVASLLRPMEQGGRLRDSIAVSRERGLRTAHLSSHSHSESTSIDENPESPILPEKPESKLATTRRTSEPSSPSGPGSLVDPFTSSMNAQGTVAGAQPSSSSEMSSLLIRSKTVRFKKPSTGGSSKKAEPKDSESQDQEEEAERRRKSSTEKVSPTSDHNPAAGGDAPSLPTVPIHIIDVDGSDADDSSDSDKQKKQSQEQQQRTETVAAGPGEPGTIYVTITDTAMMERVETNSSRSSNGRQQPFTAAAASSEEESTRSRSGTGGSMTEDVSSGDRPSLKRSSSSSSSRHKIKSWFSSHITKVEKKTEGTDAGGGGGASSEVVVTESITEAASASTSTSPSGSSSSALSLKAKMKNKLAHGQDKLKVKMDHAEEKLKRGKEKLKEKSKELSLLAIGPVRFMWKFVFVLGVIGAVWGVGSMRSMLGWTFLPVTMVVRAAGWVGGGFKGAFAGTGAGAGGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKT1</accession>
    <name>A0AAE0JKT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_457262</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Vacuole membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684538.1">
        <property type="nucleotide sequence ID" value="XM_062826348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKT1"/>
    <dbReference type="GeneID" id="87863502"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000003">
        <property type="entry name" value="Vacuolar ATP synthase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="17">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="18">
        <location>
            <begin position="321"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="16">
        <location>
            <begin position="426"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="19">
        <location>
            <begin position="659"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3351243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="807" mass="88700" checksum="2EF91EA1BBECB734" modified="2024-05-29" version="1">MQAGFRPRLKARPSLVDLLVHASRNSGPNSPTCSESGLGTGDYWDKRDSSPGKSSLRSWSERDDRGTARGHLQQEFVSWPPQVVGSAGSWLESDGDPDGEQLPLSLPLRGRLRLRPGVPHLVTTIPNSAALLDQASNLPLPPSPTKPSSDPSTPTLQLDTPARTSPERPAHKHIPTVIVTSDSPRPPLKPTSAPIALSPKMAPQQNGAEKDGIHTGKIYSVSGPVVVAEDMIGVAMYELVKVGHDQLVGEVIRINGDQATIQVYEETAGVMVGDPVHRTGKPLSVELGPGLLNNIYDGIQRPLEKIAEAANSIYIPRGIAIPALDRKKKWEFTPTMKVGDHISGGDVWGTVYENSFISVHRILLPPRARGTITRIAEKGEYTVEEKILEVEFDGKKTEYPMMQTWPVRVPRPTTEKHSANQPFLVGQRVLDALFPSVQGGTVAIPGAFGCGKTVISQSVSKFSNSDVIVYVGCGERGNEMAEVLKDFPELSIEVDGRKEPIMKRTTLIANTSNMPVAAREASIYTGITVAEYFRDQGMNVAMMADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKVEALGSPPREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINTSVSYSKYLTILDKWYEKEYPDFPRLRDRIRQLLSDSEELDQVVQLVGKSALSDPDKITLDMSTLIKEDFLQQNGYSDYDQFCPIWKTEWMMKLMMGFHDEAQKAIAQGQNWNKVREATQDLQAQLRSLKFEVPSEGQEKICKKYEAIQQQMLDKFASVIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKY6</accession>
    <name>A0AAE0JKY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_458348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684879.1">
        <property type="nucleotide sequence ID" value="XM_062826401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKY6"/>
    <dbReference type="GeneID" id="87863555"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="139" mass="15879" checksum="0EC9FE0CAE3A21D1" modified="2024-05-29" version="1">MYVRKLTNQYHHQPSFSTQQLPTYLPTYLFPIALSPLSVLFRVLRYSISRAGRAHSYEIPRQIDDAFVYLTAVMPLTICPLTLHSHTHTPLHLSAHSLWNHSCSPSRNSSAPPPIITKLTRSMMEHCDLFLIPIPCDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLH2</accession>
    <name>A0AAE0JLH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_136487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685137.1">
        <property type="nucleotide sequence ID" value="XM_062820883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLH2"/>
    <dbReference type="GeneID" id="87858037"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08996">
        <property type="entry name" value="GH32_FFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041904927" description="beta-fructofuranosidase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="238"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="567"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="701" mass="75425" checksum="629047E5B4D20125" modified="2024-05-29" version="1">MTKTIPYKNVLLGLLSLASVLPDGTTAAVLPRTAGCGCHSNHHPGPENPSFETGDLSGWTVVSGTAFGNASVTTTASYKSGSFNQVGPLNQVGKQFLWGMLQDGDAAVGTLRSSTFRASSTMSFLVGGGYDPANLYVGVVLERDGTLLFSQTATNDEALIRIVWDTSAYAGQNVYMVVVDTSTQGHINLDDVRTGCHALHDGGLSFNALGQHNQPPQNSTALSAASLYALDPIRPQFHYTPYQGWINDPAGLIQWGGKYHLFNQFNPVAPLWGPMHWSHAESTDAVHWRELPVALYPPYPDNPQDTSGRYTGSAVLNKDTGALQLIYTDATNVIWHPKAVAEVVSSAVSSDGINFDLSNSNPIIAAPPPDSASGFRDPKVFWDPTDNTWKMVVGSGDSRSGKVQLYKSTSPTSSELTAWEYVGVLHQGDDSSRGTMWECPNFFPIGDKWALFYGQDKASVGWYEVGTYNGTTFTSEKLGLLDAGPDSYAAQWFVDDAARNLLVTWMGSWTTSKWPSRVNGWAGAQSLMRELFIREDGGLGQKVVDEVSLLASGPAKSLGRTDVHNGTMTVGSSNTARLQASIDLVASTAPAFTIELFASKAESVSLVYSFGNRSLTLDTTRAGYGQAGKWSATIAKPADNRLSLDILIDRSSLEIFVGDGTAMTATVFPRYQESNNIRIVCRGGKTVFDDIVLTPLGSAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLR7</accession>
    <name>A0AAE0JLR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_141690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685284.1">
        <property type="nucleotide sequence ID" value="XM_062820942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLR7"/>
    <dbReference type="GeneID" id="87858096"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041905464" evidence="2">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="64" mass="7757" checksum="2E900A7A1B67C53A" modified="2024-05-29" version="1">MAPLAAFTMAWVLFAYTRHSIQAAKVNAKLTREQIQQQQQQQQQQQQQQQQEREYRNRERHSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLU3</accession>
    <name>A0AAE0JLU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_458813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685013.1">
        <property type="nucleotide sequence ID" value="XM_062826428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLU3"/>
    <dbReference type="GeneID" id="87863582"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="210" mass="23081" checksum="0890C025608C1AB6" modified="2024-05-29" version="1">MSSKLPTTLLRRPFALPSTTTYTAYSASRPTTQTCAQQQIRNATFVPRHRRPYQFTQLVQLSDGSTFTVRTTMPTALYKSAKDSRNHLLWQPSDKSLKNVELDEAGKLAAFRERYGRGWDLDAKMTPEEEEAAAAALAAGGKGAKKAAAEEALLAKKKAAEEEAAKKKAAAEAEAEEVDPFDSLTDLISGYATENMNPGLNVKDTRPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLU9</accession>
    <name>A0AAE0JLU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alb1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_458520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684931.1">
        <property type="nucleotide sequence ID" value="XM_062826410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLU9"/>
    <dbReference type="GeneID" id="87863564"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3351636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="203" mass="22592" checksum="2B389B9A712F3CEE" modified="2024-05-29" version="1">MAKGTIGKSNKAAAVRKHSRAARRQTSPGIDLDKSLKAVRPPQESVNLRPTVLAAHHNSGITKKNKKKQLSSKARKRQEKSMDRAEAIMDRTSTKVAKSHGKARVIESRKRTWDEVNVVALAEIGKELPTTKKEKKADKERQAEDEAVRVFYADDDEDMDKDGGEWEDEVEDMDENAAVESLMAAATIPAVAPMMQEDDEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLZ1</accession>
    <name>A0AAE0JLZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H65DRAFT_547133</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685455.1">
        <property type="nucleotide sequence ID" value="XM_062829492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLZ1"/>
    <dbReference type="GeneID" id="87866646"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="67"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="21">
        <location>
            <begin position="511"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3352160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="640" mass="71158" checksum="99B5B904CC954FA3" modified="2024-05-29" version="1">MPGPLALAGAAAATAATASYLSASLSLEHDLLWLQIAGGTVLNVIKSMRAGQINVFYRLEAHALAPSTANKPFLWFEGKSYTYHETYQQVLRYGTWLKEVKKVKEGEVVAFMAMNSDQFVFVWFGLWSIGATPAFINYNLTGTPLAHSLNESKARLVLVDPQVVDYLTEEAKGQVQGGGGEKGMEYVVLGPETEAERFQLEPKRYADKVRKVDSYVGMAILIYTSGTTGLPKPAIVSWTKVIMAAMVTGKGTSMRADDVLYTCMPLYHSSASCLGVCAALFRGATVAIGRKFSTKTFWEDVRASNATIIQYVGETCRYLTVAEPEIDPETGRNLDKEHKVRAACGNGLRPDVWEKFKGRFGIDTILEFYASTEGPMGTWNRSRNSFSLGAIGRFGFLSHFLTNLRSAVVRLDYETDQPWRDPVTGFCKRTRTNEPGELLALLPADVKSRFQGYFGNEKATNSKMLRDVFKKGDIWFRTGDIVRWDAERKLYFSDRIGDTFRWKSENVSTAEVSQAIGLHPSVQEANVYGVQLPNHDGRAGCAAISLEGGEPNKEVLESLAKHARKTLPKYAVPLFLRVMKEVGGQTTGTMKQQKHVLRQQGVDPGRVGKEGDRLYWLEEGSYVEFGEKEWRELQGGRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLZ3</accession>
    <name>A0AAE0JLZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mis6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_458796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685006.1">
        <property type="nucleotide sequence ID" value="XM_062826424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLZ3"/>
    <dbReference type="GeneID" id="87863578"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3351711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="726" mass="80746" checksum="79FE987DACE14256" modified="2024-05-29" version="1">MSSVEGDHNTNDTSVNLGDHDHVGALLDDIEAASKVPSKRRQTSIKPTVESLTSVLYDRGALPDELARLVDLVTLTNHLDQASKGAIIKNLYPVGKLNNESALKVVGALGHGQLKPSFPIQSLLLKWLIMVYHLLQDTSILSQTYGVLFNLLDTVAIRPQLCHVLALITRRKHVKPFRIQTILSLSRQTGNDPNLTGLLRVFKNYYPEIIVGDAAKGRAATFKHPDPQWRARLDEIQQQQTEAIQDGTVRNGFAVRSAFGRQQRGAKGIFIPAVHTLHAQENSVTLEEINSPKSLAENLEKIELPTQLVAVLADPLLQKLLLLRPDAEGLSRVNNWVTACLDDVRSGDADPSLLLDMIDIIHDYVASTKTLPPLLINFFREFLQVWNGKDKRETVIETLSFLPLTNFKDLYQTLLRPFESVLLDNTPESQLSLLTFYTSLLRQWTLTMLSSDSTTLSSSPAPQSIPALIAHVNTLSLTLTQTSPTVPTHLLILDFYTLVSTRIFSSPSLLKHIPITIPPSLLIYTLHFSHSLEVVSRLCGILATYKRAWESIMVSTSPSARPLFAEERQQITTFNAFLMDLCNVLWRGRAFAVSDANAKGCLVPRALEAALRGYLKKVEPDGELVLGSVFGLSHSPVLCLQSISFLRELEDRELEGEMDISDRGLRARHAGPVTQQSLVALAGKGGLEISWQEYRAGVLRYLEERGFKGVPELMYNTMKNLMKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMF5</accession>
    <name>A0AAE0JMF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MADS-box MEF2 type transcription factor MIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_7807</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor acting downstream of the MPS1 MAP kinase (MAPK) cascade during conidiation and plant infection. Required for overcoming plant defense responses and the differentiation of secondary infectious hyphae in live plant cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAPK MPS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685677.1">
        <property type="nucleotide sequence ID" value="XM_062831409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMF5"/>
    <dbReference type="GeneID" id="87868563"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="573"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3354299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="623" mass="67571" checksum="59E1402A8A8005A5" modified="2024-05-29" version="1">MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELSVLCSVDVAVIIFGNNKKLYEYSSSNIRDILQRYSYHGGPNEHKGPSDFNGGADDDDDDDENGTNSQGEQHIMYQPNPPVSYPFLRHTSLSDSPPVPNGAFGPQPGHQMSRAHTPQPPFVARPSSVNDIRRLRPGQPVGPAGVAQELQNRSAFVPSPPIYNPQPPATMAPTHGLPTQLHPQYPFQPSQPPAHPMQQFEDQRRSPLPPTFVSQPPPHPAHRHSTSPPELLQPQIPQQQVHRHSASPQVHQAQLPQQPQRLPSANMSPPPPQPAQPPQQQHHHQQQQPQPMSNQNLQPPAPPKPESMERPRRLIPALNTSVKNPGQGSVFTPIEPENKSILSQHFAAFRPDIKSESPNNRSQCVDGGNVSKPNTSTPSIQLSSAHGQGSAQRTNSLTAISQSTLPPPSRPQHLRVGGGPVRPRLKVQIPDDSDSGSAAGSASSPRVTTTTDSAPQPLKTGPVLPPPSPSASNLPSAGATGPPNPFAPRSTIQHNNNMNIDTPVSALPSRFLGDLLPSPSRFYPEWGYGISGESNTLPSPLNFATPVNGTGPSFLRDDPTPLKRKSPETKSTGPENDSGSNHDAKRMRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMN6</accession>
    <name>A0AAE0JMN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_448332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685799.1">
        <property type="nucleotide sequence ID" value="XM_062825902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMN6"/>
    <dbReference type="GeneID" id="87863056"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="3">
        <location>
            <begin position="226"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="365" mass="39374" checksum="575887235911AEAF" modified="2024-05-29" version="1">MDPHDLDHRDHRLSHKASQETFISLVQLDPEPILDPYQEDGPDFDPTRDASPSDDAGEGGSLADSIHSLKSSGSGGTAGGIGLTNTTTPLGLSGSGHGAIYYLTRIQRYSSYTFSLFASLHLATTSVIPVLARSVPASESYLLLAREIYQTPLSEPLLVALPIVAHVGAGLLARLLRRRENLRRYYGVGSDEKTHGLIAKPTARFLRSGWPRLSWIALSGYSFTAVVAAHAFMNRGLPLAVEGDSANIGLAYVAHGFVRHAWTSWLAYAALLGIGCGHMVWGWAKWFGVSQGAGWALERHTGVPEVDRKARRKRRRRLIWINAVAAAAAAVWAAGGLGVVARGGETLGWVGKVYDGLYEKVPFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMY1</accession>
    <name>A0AAE0JMY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_437576</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685568.1">
        <property type="nucleotide sequence ID" value="XM_062825318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMY1"/>
    <dbReference type="GeneID" id="87862472"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="129"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="251"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3354190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="395" mass="43028" checksum="DD1FC0C22EE0AF19" modified="2024-05-29" version="1">MATNGVNGAKHYNEGTFLFTSESVGEGHPDKIADQVSDAILDACLAEDPLSKVACETATKTGMIMVFGEITTKAKLDYQKVVRNAIKDIGYDDSSKGFDYKTCNLLVAIEEQSPDIAQGLHLDDRLENLGAGDQGIMFGYATDETPELFPLTLLFAHKLNAAMSAARRDGSLPWLRPDTKTQVTIEYKHDNGAVVPLRVDTVVVSAQHAPEITTEELRKEILEKIIKTTIPAKYLDEKTVYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYVGRWIAKSLVAAGLARRALVQLSYAIGVAEPLSIYVDTYGTSEKTSEELVQIIRNNFDLRPGVIVKELDLAKPIYLQTAKNGHFGTNQTFSWEKPKALKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN60</accession>
    <name>A0AAE0JN60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_449290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686070.1">
        <property type="nucleotide sequence ID" value="XM_062825942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN60"/>
    <dbReference type="GeneID" id="87863096"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3354692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="608" mass="67514" checksum="0391554CCC562C33" modified="2024-05-29" version="1">MDTTPMMARAGLLQTSLIWVAYAVAVALVFVVAVITVFTWQTPYDRSKLVTTVAIVSLTSLLATVFLLPVDIALVSSTASASRGTKKDWATPERIDGILTTLKIVYYSLYSFDALLCLVVIPFAYFWYEEHDEVLEEEGRESWSTRFAQALKYTIAFIFLVIILFLVGFFVPAAAQDHGRHLDLDYFRRLLTNNKGEKALSFGLGLLMTLGTLLYVLYTGAGLALLPVSFIKSAPSISAPQLSATTASELEHNRELQRQIEMRNAGRIEAMSQKDRRELDLLLREERTLVRRQRLAAEARGEGQSTIIRIWTKTQAVFRPLKLVGGILLLFLSVILWISMLITAIDKAANSVCKSHCGYILGHINVFQPVNWVFVKAAKAFPVDYILMAFLILFLFSSSITGIASVGIRFLWVRIFQLKKGRTAPQALLIATVMQALIILAINYAVVNLLAPQYAMYGTQTFCQGFARFPSAQPDCTNHRDMIRPCSESLTDPLAKDVCTPTVMSTFLNRIVLNWPVFGAIDFWAQFAFLTVFLLVFITSLVRTPRLNLGEIDEEAQADEEEGLLASTSRRFGATWQDITGRARRTVGGSSGGQGYGTSGTNGTNSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN84</accession>
    <name>A0AAE0JN84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_10788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685763.1">
        <property type="nucleotide sequence ID" value="XM_062820518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN84"/>
    <dbReference type="GeneID" id="87857672"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="288"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="506"/>
            <end position="510"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3354385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="621" mass="68645" checksum="C71AB089C67ED8AA" modified="2024-05-29" version="1">MLCRAIPRVSRRAVPARTSTSSLSGLCARSARTTTTTTTPAHARLLSTSAARMTAPSSLAPVEHPFSSTIASESFQLLPEEQKAGAAEDALLQQQIKEVEAWWASPRFKGIKRDWSAADVVSKRGSLQQTYTSSIMARKLWNLVQERYTQGKPIHTLGAIDPVQMTQQAPHQEVLYISGWACSSVLTTTNEVSPDFGDYPYNTVPNQVQRLHKAQSMHDRKQWFLRSKMTPEERAKTPYTDYFRPIIADGDTGHGGLTAVMKLAKLFAENGAAGVHFEDQMHGGKKCGHLAGKVLVPTGEHINRLKAARFQWDIMGTENLVIARTDSESGKLLSSSIDARDHEFILGVADPSITSLAETLADMEARGAPGPEIDAYEAEWVKNTKLVTFDEAALAHFEKHNVRQDLFGTYKATIAQNPNMGITARRALANSITPEHPVYWDWDVPRTREGFYHFRNGMAAATKRALAFGPYADLLWVETGDPSVEVCTELGRAVREQFPGKGLVYNLSPSFNWMAHGFTQDTLKSFIWDIAKEGFTIQLVSLAGLHSTATITSELARRFKDEGMQAYVELVQKREKELGVDVLTHQKWSGANYVDAILGHIQSGSSSSKSMGEGNTENQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNX5</accession>
    <name>A0AAE0JNX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_32217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686384.1">
        <property type="nucleotide sequence ID" value="XM_062823427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNX5"/>
    <dbReference type="GeneID" id="87860581"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="192"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3355006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="411" mass="46950" checksum="529D8D2BD7D298FE" modified="2024-05-29" version="1">MDGDPVVESELDSFSLTFPLPYRVAFIVVLAVWGWGLNLHFLHLRKIDVPSLIRYPGRSSTTQLPHHHSTYRLATLLSLSSALSILTFWSFTRRDPKRVIDYDWIPMTNLAVTAALFVLPLRRLSVSHSGRRRLLATLRRVSVGGLAEAKDGKFGDILLADVLTSYAKVLGDLFICLCMFFTRNGSATDRPDRGCGGTYLVPLLLAIPSAIRLRQCIIEYLRVRNSPFKESTGWGGQHLANAAKYSTAFPVIILNAMLRNANTNGTPTTGLYRAWIAACLLNSLYSFYWDITKDWDLTLFAGAQERNSPDHPFGLRRRLLIHKPVVYYFVIALDLALRCTWMIKLHPHLNTISDFESSIFLVEFFEVFRRWVWIFFRVETEWIRNTSTGLGVDDILMSNFNTRDEDEEYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQF7</accession>
    <name>A0AAE0JQF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_62627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687282.1">
        <property type="nucleotide sequence ID" value="XM_062831177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQF7"/>
    <dbReference type="GeneID" id="87868331"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="588" mass="65809" checksum="5E7BF987B594F05E" modified="2024-05-29" version="1">MATTTNGHINGDDPKTKFTLKDSPVENLRPLRVVVIGAGYSGIGAAIRIPEKLRNVELVVYEKYEGIGGTWWVNTYPGVACDIPSHSYQFSFAPNPNWSNLYAPGHEIQKYLQDVAERFGATRFIKLSHKVEECVWDDGEKKWQIKVKNLVTGEVFTDSAHVLITARGQLSEPRWPDIPGIDKFEGKKMHSGAWDKSYDLRNKKIAVVGNGSSAIQIVPKLQELEGTTLSCFIRSPVWISSAFGDGTMKDLGLDPKVTEFTEEQKALFRSDPSALLKFRKAFEDFGTSLHNSTIAGHPMNIESQAFFKADMESKLSGRPDLLAKIIPAFAPGCRRLTPGKGYLKALQQPNVTTIHDPISHITTTSIALTTEKQIDADVIVFATGFQACTSPPFPIIGRAGLTLASRWSQHPDSYLGVAVDGFPNYLMLFGPNTTIGFGSLNRILEAQVDYVVSVIRKLQKEDYASMEPKPERVRDFVAFVDAYFKDTVYLDKCKSWYRSEGGVGDRIVALWPGSTQHAVEALRSPRWEDWVYESADSSGNGLRWLGNGWSWTQMEGDPSWYLNPEEIEFPWEGKPEENPKYKSRPWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQM8</accession>
    <name>A0AAE0JQM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_63621</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687310.1">
        <property type="nucleotide sequence ID" value="XM_062831188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQM8"/>
    <dbReference type="GeneID" id="87868342"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
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    </dbReference>
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        <property type="entry name" value="RPE"/>
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    </dbReference>
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        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3355932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="251" mass="27246" checksum="AFA38E7E64A13672" modified="2024-05-29" version="1">MAPKAIIAPSILSADFASLGHDCSKTISQGADWLHVDIMDGHFVPNLTWGPPIVAKIRGHVDKPTEAYGKGTFDCHMMIAEPKKWVKEFKKAGCDLYCFHYEAAFSTAAESPEAKSDEKTSPKELIKYIHNQGMLAGIALKPATSVDVLWEILESEDPKERPDMVLIMTVEPGFGGQKFMASELPKVQELRKRYPELNIEVDGGLGPATIDQAADAGANVIVAGSAVFGAQDPSEVIALLREAVEKRNGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQR0</accession>
    <name>A0AAE0JQR0_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_66537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="167" mass="18997" checksum="F73FE7BBDD0392AC" modified="2024-05-29" version="1">MPSNHKQPHPTTVSSSHDLTNSHPFPQDSPHNRRKRLHRQRRSSRLRPRRRRRLARLRPHPLHQQQRKSPPIIGAIDDVAAAHESEFILAQLLPPRRVDVVISTTESFWPDYAAHYHNVVALLRRIVASESKAGDGDGDGDGDGEKGIKLKPPLLVFTSGCKDYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JR29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylglucosamine-induced protein 1</fullName>
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    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_69203</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687519.1">
        <property type="nucleotide sequence ID" value="XM_062831280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR29"/>
    <dbReference type="GeneID" id="87868434"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF4">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28573" checksum="0986A6B7AA30EF22" modified="2024-05-29" version="1">MGSTTPLPPLSTPDEDRPYWQTNAPPSHPSATSPICPPYLLNLPPKDLVTISTPNHLYRLDTWPEVVLRVRENRLADFQRTPADMWRYLEFCYTKKEEYKDKGGIKGFILRERLKWDFPEEGDTGRKRRFGEREEEDVKVLWNDWPYGIDERIVHLVVWTKFELEDDPATGDLTEKARGEIDDYVKRTFGGRVPGEHIIWFKNWAHIKSVKAVEHFHVMLFDPDPEFVREITKGDVPLGIIQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJL2</accession>
    <name>A0AAE0MJL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_336622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677058.1">
        <property type="nucleotide sequence ID" value="XM_062823574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJL2"/>
    <dbReference type="GeneID" id="87860728"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="131" mass="14247" checksum="822A9F5768BADBE0" modified="2024-05-29" version="1">MMFLTSFFSFSFPLFVIPISNRVLSFLLLFSDDSCSLGYVIASPAVGGLVILRNLLISSTARFASFRFLFVSCCASCYARIRYGLLSNAPRTSEREGSVTQLDRDSRDNAAAAAAVSDSRGSNNDSDSTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMT0</accession>
    <name>A0AAE0MMT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_316718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677718.1">
        <property type="nucleotide sequence ID" value="XM_062823374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMT0"/>
    <dbReference type="GeneID" id="87860528"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="123" mass="12995" checksum="C2B24CCCA15804FC" modified="2024-05-29" version="1">MSTQSGSDTTKKSKRQQKKQAQTYESESESEDYAPPPRRKRGKQQGPLDSLALDNVGNTVGGVTQGVTGALGGITGSAVQNQQQGGGGGGKSDTLRLRLDLNLDIEITLKAKIHGDLELALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN36</accession>
    <name>A0AAE0MN36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_434714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678018.1">
        <property type="nucleotide sequence ID" value="XM_062825148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN36"/>
    <dbReference type="GeneID" id="87862302"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="8">
        <location>
            <begin position="475"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="734"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1120" mass="124462" checksum="EF059F9A6C5E8E72" modified="2024-05-29" version="1">MSSVTTNGHANGINGTNGVKPQKSNVDVLIVGAGPAGLMAAAWMAHCGINARIVDKRNTKIFTGQADGLNSRTIEIFESLGFADRVWKESNHMQEICMWNPNAEGIIHRSDRIPDTVIGISRFQQCVLNQGRIERWFTDNIKKYSNNTISVERGVLPESLVIDESKVEDDDAYPVTVTLRTLTDEEATPVQAATASKSAVSDGLFRSNLMQEDDEAGLLRKAQSRPGTEEIVHAKYVIGCDGARSWTRRALGLELEGEATDYIWGVMDLIPITDFPDIRHRCAVHSAENGSLMVIPRENRMVRLYIQLKEVVPDASGRADRSKITPDLIFRAAQKIIAPYKLDYEYCDWWTAYQIGQRVGNSFADVHNRVFLAGDAVHTHSPKAGQGMNVSMQDTFNLGWKLALVLKGICKRDILATYQSERRRIAQDLIDFDHKFSRLFSGRPAKDMMDAEGIDMEEFKRAFMRGNEFASGMQVDYGPSNLVVKPGDWREQGDRSEKSAKLLTEAKISDDKFAKKQALATEIPVGKRLASFKVLSQADARPWHVQERLKADGRFRIVLFAGNILSPQQKARVDRFCAKLDSPESFLRRITPADKAIDSVIDILTIHSSPRRETELLRDFPAILHPFDQHLGWDYTKVYVDDVSYHEGFGDAYKNYGVDKERGCVVVVRPDQYVAWVGDIDDFEDLENYFEGCLRLPAVGAAQDISIVTETVSSVTSKVAGEVKLAVRAGIYYMRRWIIGAYILMPLTYIACVCVALLQCIPPSRQWQIYPDPGNHCQPAISVLQTVFVMIMNTATDFYLLGIPLPILWKSNLPWTKKLVLLVMFSGGFIEMAFGIMRCVSILTRGNRDPAQTGYWSVRESFVSFVLTNMPMIYPLLRRLMDHVVYSLGGWVDHVVYYLGGWSRQSRTKNGGTTTTNKKNISIKPNGFMLTPQRSPYPIDSPMFSPTYSGESRGVTGRPGPIPDPLFPIPGSDLETFWVSTTSEETGTGPPGSSRDSRQTSHATVGSQSGMVSYQSNCDSPTRSRNDCRQTMQTAHGPYFGIVTSVESSGMIAEQPHHGWCSGESSSSSDNGTAGGAGGIMVTREVGVVIEEGVCPPRPDTPGLPPPAELWGWGDFHLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN45</accession>
    <name>A0AAE0MN45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_315595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677676.1">
        <property type="nucleotide sequence ID" value="XM_062823365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN45"/>
    <dbReference type="GeneID" id="87860519"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="5"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="784"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="827"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="719"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="934"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3338225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112667" checksum="7CB72666B3186709" modified="2024-05-29" version="1">MVQASMISVPLKATNEIDWVAPLKNYIQNTYGDDPERYAEECATLNRLRQDMRGAGKDSTSGRDLLYRYYGQLELLDLRFPVDEKNIKISFTWFDAFTHKPTAQHSLAFEKASIIFNISAVLSCHAAHQLRTEEAGLKTAYHSFQASAGMFTYINENFLHAPSSDLSRETVKTLISIMLAQAQEVFLEKQIADQKKNGLLAKLSSQAAALYAQAVEGVQENVTKAIFEKVWLSMVQIKLNFMNSLAQYYQALADEDANSYGVAIARLEIAQSLAKEANKMANSFPSSVPPNSNLTSDCGHILADATKRHLATVKEKLEELNQENDMIYHQPVPAEASVTPVPKLPAAKPIPVSELYAGQDIQRITGPDLFAKIVPLAVTESASLYDEEKAKLVRAETERVETANSEMAASLDYLRLPGALQVLKGGFDQDILPDEDFRTWCVDVADHENPHKIFEYLHTEKQAISTILDKSSRQLDMEESVCEKMRSKYDAEWTQQPSSRLTTTLRTDIRRYREALEVAAKSDGQLATKLRANENELDEMRQAAQHGEIDELFQRAVKKLRKSNPNSPATVEPNLLDADFDDGGPSVVEQIQKVEDILKKLSLVKKERLQVLQDLKQKAHSDDISQILILNKKSIANYEQQLFQQELEKFRPHQNRLVQASHKQAALMRELTVTFNNLLQDKRVRADQSRYESVQRSRASVINKYKRAYQEFLDLEAGLQSAKNWYKDMRQEAESLEKNVEAFVNNRRAEGAQLLNQIEQDRAANKSSHAALEQERLKNLMERMSMDPSPTSPKPSSGSGGRPTPAPLSFAPAAVSSTPLSAYQKSNFSTQYPASPPATQIAHNPGGQQQTPYQQYNPSSLGRIPGPASPPPNQTSFNIGPGRHPASPPPTQTSFAHSRPYSLTTYGNPSALNPQGGQPGQTQQSQPGGYVPPGFVPPPPPPGPPPLGPQQTVHYGGNEYYAGAMGNPGIGRPGSAQQGPQGPQGQQGGWGQPPPQHPQYQQQGGGGGDPWAGLSAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNL4</accession>
    <name>A0AAE0MNL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_478418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677734.1">
        <property type="nucleotide sequence ID" value="XM_062827482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNL4"/>
    <dbReference type="GeneID" id="87864636"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000465">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="270" mass="29140" checksum="1FEF027A8340292E" modified="2024-05-29" version="1">MTTLMDPATQAPLPADAIQRILHITNSSVHIYQIPPMRSTKGHMAADWTVDPKAHIFTGRVRIIETSIPPQTPEQVGEKDTVKVDIVLEDPATNDLIAAAPYTTQAVVEAAIDSSRFFALRVQDPNTGKKAMLGIGFEERSEAFDFGVALQEAQKSLGLIEGVAPLIKSGKNKQEAEEKKDYSLKEGETITVNLSGTKFGRRARQDRPLSTDLGSDSQPPLSAFSLPPPPSSSSAMPFLPPPPSSGRGGHRRQPSAQELGFDDGPNGMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNU0</accession>
    <name>A0AAE0MNU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_445682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678872.1">
        <property type="nucleotide sequence ID" value="XM_062825760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNU0"/>
    <dbReference type="GeneID" id="87862914"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003040">
        <property type="entry name" value="Guanylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3339512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="194" mass="21587" checksum="B2314EACC916512B" modified="2024-05-29" version="1">MAPILPPDRRPVVISGPSGVGKGTLFKLLFERHPDTFTLSVSHTTRGPRPGEKDGVDYHYVTKEAFEELKAKGGFVESAQFGSNFYGTSKATIEEQSAKGKVVVLDIEMEGVKQIQASGFPARYVFIAPPSEEELEKRLRGRGTDKEEDILKRLTQAKNELAFSKTGVHDKIIVNEDLEKAYKELEEFVYAPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MP67</accession>
    <name>A0AAE0MP67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_431215</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679262.1">
        <property type="nucleotide sequence ID" value="XM_062824931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MP67"/>
    <dbReference type="GeneID" id="87862085"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3340320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="86" mass="9467" checksum="79C1657D9EB29765" modified="2024-05-29" version="1">MSDSTSETVKKAIIKQVLIESQSANARTLMEKIGENCFTSCVPKPGSSLSSAEKTCVAQCTEKYMAAWNVVNTTYLKRIQQEMGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPD7</accession>
    <name>A0AAE0MPD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_258805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679368.1">
        <property type="nucleotide sequence ID" value="XM_062822589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPD7"/>
    <dbReference type="GeneID" id="87859743"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="811" mass="85994" checksum="7529E529149C5BF4" modified="2024-05-29" version="1">MAALVQGYPRQSGTATMLQTRPASSTGIIQPTQSQSNSQYGHNMSQRNNSIHGMSGVVGAPVVYRPASGSVQQYAFTNAPALNHGTHHHQFRQHRTSSTPSVPQVQNFDQSGARPRYQSSNSMSSIPSAATSSGQSAGGSRDDSVISVGSSRRVAPLPRPHSAHLGEIFSVPLIASAGPAKVSPERYRRPAQRANESAPTMSNTSEQKSGMLRGPNGSLAHRPNSFSLGGSAVDDMLLPHGQIREDVKRARRSSMPALDSAGLAVPLNPLYAAQPADMSSKSRKTGEKEIKTSGRTVNNLSVDRVAAHTRTSSTDSRSSSRSTASSGTRPASSANRSANVANPTGNPAHSSIPEQHHSNGQDHARLVNIPPRGSSSDATNTKRLANPSPLSKPVAMDTEAGRNATAGAAAGRSASPVKTTPSPRVDSPAAKQLAAVSQNDSKPKSKTSRLRRAFSFGSAAEFRKAVYHQDAENGPSKLHKDRNPDELLDAEQARIAQQQEAAGIGSNIYGPRIFGGSTDNLSISSTASSASVMIRKMGRGMKKSTRSLAGLFRPKSVTGVPAADAKAPDASRAAVSMITVEAERERVNVNADVRSQNGGGTGFPRLERNSLDASRAPGLRTERAGSLGSEGSAARKSIISGERERAEVLAAVRKGILKHTNSNSPSPSPRPAENRGLDAPSAITDSPNSSAPSTPNNDDRAGQVPIGNEDYFVTALRLRQDTKSAPGTPQGSMKRNATFSPRIAFYETWPSQEYDRRGEVATCNRLTPVLAQQIKEELNSFKMVRFTDRYLRLGRMLTLALLLGNGSSREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQI1</accession>
    <name>A0AAE0MQI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_251891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="70"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="241" mass="28075" checksum="95CA37400FA52C3F" modified="2024-05-29" version="1">MPYIIIRYPDLIRWQLALGLAQHDLSTPPKDTFTDRVRNLPRFQDYDHYLPLFIGFGIVGLIYGGLHCVAWNAPFTTSIERILWRISSITIAAAGVLVACVFSWTRLPPFWQGPRLVYRTIEEFVDRLIDYSIILWVFEMEMELSDRLETFLQKRTFYKNNELLCALLGLLPILPGFSLYLSTIFLLYLFKVLFDIFAVLFGVLYVLARIYLVVISFINLAHLPDSAYLLPQWSRYVPHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="129"/>
        </location>
    </feature>
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            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14510" checksum="EE07296F153BE1CD" modified="2024-05-29" version="1">MAGFYMQYLESLCRRRGWHDPSYECYRDGSGFTCLVLVNGREYQTDIPYESHGLAQENAAMRAFMVCRNFSVNGGMLARNGIVQGLPADEAKHKSRRSSRPHTSSQYTHGHRNRHSGDESSSSSIASTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MRA1_9PEZI</name>
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        </recommendedName>
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    <organism evidence="5 6">
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
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                <person name="Ohm R.A."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRA1"/>
    <dbReference type="GeneID" id="87858717"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    </feature>
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        <location>
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            <end position="206"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3344780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="206" mass="23738" checksum="63004A3997C6E709" modified="2024-05-29" version="1">MRPSSVILAAVGLTGTALAHGDHGSGSQKPIVDENAPWMVKHMAEEHHIENFDAASFFALHDFDGDNTWEGLEILRTYGLMDDSNKHVSQPRRDEIVRDILNLIDYDRNGVITKDEFVRFIDVEKKTLPDMGTGPGHHGDAEYEYEIHHWEKYHDDNTKLEDLTHPEDIEHFKKHEEMELEEERLAQMDKIAIIEENIPAKFRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRZ1</accession>
    <name>A0AAE0MRZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_573817</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681726.1">
        <property type="nucleotide sequence ID" value="XM_062830562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRZ1"/>
    <dbReference type="GeneID" id="87867716"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <name>A0AAE0MSK8_9PEZI</name>
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        <submittedName>
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        <name evidence="5" type="ORF">B0H65DRAFT_212568</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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    <reference evidence="5" key="1">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_062821953.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
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    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="302"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3345728.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_155584</name>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="546" mass="58585" checksum="81EEBBC583589323" modified="2024-05-29" version="1">MCTFCYTPYIGCPKGRRHYYLQWLKCKTAIKNGHSYCPIGESTEVRELQKLSGNVLACPFHTHIAIQQIEFEFRQRDEVPSPIESSEPSSPTTSNTTCVASENESEVEVNHASQKSLYRPSSTAVYLDLRFPNSGPIKRHKSASPLKTETRKTHRSTGGSLDSRSEPNKSITCDQSPPSSSKRRPLISPGLPASPAAYRQSRSRSRSQPPLQPHAKPTLKALKTGLDTSTKTLGDANEFSKPAHYPLAPSPPPPEIITTLPTPVDQVKPSNPDLLTRRLGPSTALTISITKAPKLTIQKITSSKSEPELKSTSKGPESSKSTTTTTPHTFDSFLTPSGTLQTDAHSTPTPTSTAGNTTKSSSSSNLFTRLKDNTTTTLHHPALSRTLSASTSTNRRRQAPATDPRNIAPWDQVLLPASISKPVNLEVGENSSTNIKKPTTVLDGTNRAGSEKTNAIDGHLLQGRLGGQGPRTAPLPAEMEVMMSRLESVGVGVGLGIGLDGVILSVDDEVNPIAGQHKRSGSATSLRGRMGLGLGLGLKKRGGECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT32</accession>
    <name>A0AAE0MT32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_508125</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683237.1">
        <property type="nucleotide sequence ID" value="XM_062828202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT32"/>
    <dbReference type="GeneID" id="87865356"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042071645" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3348155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="242" mass="25516" checksum="CD0DEA9A26DC7A70" modified="2024-05-29" version="1">MKLSTALVLLASAIAEGHYTFPSVGDSADWQYVRTTANFQDHGPVPDINTDAIRCYERDAGKGAPGILNVTAGQTLNYNAKEVISHAGPMAVYIAKVPNGQTAATWDGKGNVWSKIYQDYPTISGGMSWPSQGQKSIGVKIPECLQNGDYLLRAEHIGLHAASSAGGAQFYVSCAQISVSEGSGSYSPRNQVSFPGAYQATDPGIMIDIYYPVPKSYTPPGPAVESCEEASSSCPASSIGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT76</accession>
    <name>A0AAE0MT76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_159813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683016.1">
        <property type="nucleotide sequence ID" value="XM_062821218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT76"/>
    <dbReference type="GeneID" id="87858372"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="206" mass="22294" checksum="B22E24C78C64F9D1" modified="2024-05-29" version="1">MCTYKTHIRVCRRCSSEDTVLISEQLCSVAKNSGSGIFGSCLSGVSSQRDQTGYKCWQCQDETTTSSASRSRSSSGSGSNSPNSSTGGGGGRRRGSSVSVGVPIGPQGVNSMYGYNNNNYHYGVMGGGGGVHNRGQQQQQQRRISVSGQATTASMMMQGQGREYVPVPPVPLSVSEQQEQQQDLERRLRRMGKMKADLRRYDGRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTJ8</accession>
    <name>A0AAE0MTJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_211848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682295.1">
        <property type="nucleotide sequence ID" value="XM_062821943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTJ8"/>
    <dbReference type="GeneID" id="87859097"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="315"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="415"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
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            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="61"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <end position="171"/>
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            <end position="214"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="489"/>
        </location>
    </feature>
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            <end position="540"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3345682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="577" mass="61453" checksum="26DF101F4CD844C0" modified="2024-05-29" version="1">MAAPQQPDINSILQLLNATQRPATSTPTQSQPGLPAPAQPPMPPAGYAHPPQQPPAYPPQQPQYQQAPGYYPPPAASGGIDLSAVRPVNSGTVDIQDAVAKARAMAAENGLVPYEQSARPYPPHDSRPHDSRALDNRPYQRARSRSPRGRESYRDNVNPYRDERRGGDHGHHGGQSRDYGRERSFSPGRGRQGFSPRGGHGGRDRSPLRGKEGDTETIQIESSLVGLIIGRQGENLRRVEGESRCRVQFVPPSSPTEQYRPCKITGPRAQRDEAKEMINRIIRDSGMRGSAPADRPAPRDTGRGGSAAPPPLKEGEDSLQIMVPDRTVGLIIGRGGETIRDLQERSGCHINIVGENKSVNGLRPVNLIGTPAAAKTAKELILEIVDSDSRNASNPGGNRPPRNDNMGGGGGGGYDKQNDSIFVPSEAVGMIIGKGGETIREMQNTTGCKINVSQSSGAGETEREIGLVGTREAINRAKRAIEDKVDAAKQKSSGGAPPRRGQHRDYDNPNYGQPSNNNSVPQQNLPAGNAAAPAGAGAQGDPYAMYGGYDNYVALWWQSQLAAAQGQGAAGQAPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTL7</accession>
    <name>A0AAE0MTL7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_172557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683391.1">
        <property type="nucleotide sequence ID" value="XM_062821385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTL7"/>
    <dbReference type="GeneID" id="87858539"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="142"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="306"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="779"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="797"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3348309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="809" mass="89546" checksum="9AD2B4C2B8311C71" modified="2024-05-29" version="1">MYDEHWYSFAPEVQQSRPSGAKTRHRRANSLLQQPEETADNNIPEEPLPALFEDQEDVNAPPEATVLRRAKSYSDFYDIGSHGGPKRREKKKTKGRRNNHNLWDALMIPASAASTLPVEQDTYDDALNQELLQASQQEYLLYHDQLALTERHLGTLIDDANSALKTLESLCQSFRAVEEQTTSFKAQCDDLLEEQKRLQTLADEVGTDLHYYAYLDNVSRRLNALGAGRLVDDDAFGDILANLDSCIEFMIKHPQYRDADTYQARYQALLTKALHLLEVGFTNRLDQVSGELARQITNTQSESARHALAYGRFEEILMNSYSLIPNIQRVILGAYDQNGQPRTGPNVDIFANTANNLFHAYFVVRDRDLKPLTQHDLATFHLECKESSIDTAARNYVKQCFERSFSEATLFRNIFSIEAPYSPNQKSAFAALNSHQRSLVTGTNIAPIATNLQSKLQTCDLQTICNLVGWVTNEYLLVDYDEDETPFVAHCRELTSRLLAEHLWTFTDGFFDAEITKSITKAVVPPEALKLGVTSTAEGGSSPAFPVVKRAIELLVLFDQSMPKERCQRSSPVIFKLVRETIAALQRAEVRIKAAKNGTDPDLFMIKNLLILKNELLTLEIGDVRNGTGTGQATGLGIGSIQHLGQIWENLPTAGNLFGLVSSSVSTFSSYIPGSSLLSRAAGSITGSGSGSGSTTATPAESQDAGEQLDELLRQSIYAFTRRWAAIFNEAKVKAAVGGKNLTQLERELDEILEGAFATQPEVVEKLKEAIQLDAQAQLTGGGAKAGAKEKRSVYTGGSRASRGSSRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTR3</accession>
    <name>A0AAE0MTR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_508336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683526.1">
        <property type="nucleotide sequence ID" value="XM_062828213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTR3"/>
    <dbReference type="GeneID" id="87865367"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042210275" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3348444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="425" mass="45132" checksum="160907CD285E0022" modified="2024-05-29" version="1">MRTRITHALLLAQSITTAVTTQARDNTYDYIVVGGGVSGLVVANRLTEDKNVSVLVIERGYFDDKPEAIVPYYANSLDLDVLISPTSAPNPQLNNDTFSVAVPAVVGGGSVVNGMGYLRGSKEDYDAWEALGNPGWGWDGLLPYFRKSTTFTPPTSDAVRDFQYPDIATIWDAFRSQDDVPVRAGGNAGDGPGAYWLPSTIDGRGMTRSTARKAYYDPVNTTRPNLHLLTGHTAREILFTGSAPSPTANGVRIVSRANNSTRQVYARKEVILAAGAIQTPQLLQASGIGPSSVLKAAGIRVKKDLPAVGANLQDHATTILIFSLTNQSFPNPDTITTNTTYFAAIWAEYLANLTGPISAAPASSAILFGLPHLNSSAAASVTSTKLLSQSSTLTYLPSNAPSSPNLFLSPAVPSPSTPLTPLDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUQ3</accession>
    <name>A0AAE0MUQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_463500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683540.1">
        <property type="nucleotide sequence ID" value="XM_062826705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUQ3"/>
    <dbReference type="GeneID" id="87863859"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3348458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="184" mass="19730" checksum="F58942B2422F851E" modified="2024-05-29" version="1">MFSRSVRTLSGRVLANAVRPTVIPAARQIAPALAVAARRSYHEKVLDHYSRPRNVGTLDKKDKSVGEGLVGAPACGDVMRLHIKVDPETGVISDVKFKTFGCGSAIASSSYVTELVRGMTLEQASKVKNTEIAKELCLPPVKLHCSMLAEDAIKAAIKDYRTKNPQAMPTNLAGTGAKFETAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV45</accession>
    <name>A0AAE0MV45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_458611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684951.1">
        <property type="nucleotide sequence ID" value="XM_062826415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV45"/>
    <dbReference type="GeneID" id="87863569"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="175" mass="20208" checksum="853B924A7987FBB8" modified="2024-05-29" version="1">MSRTLPNIIITGTPGVGKTSHCELLAERTGLKHLSVNDVVKAKECHEGYDEEYQSWIVDEDKLLDAIEDEVKQGGCIIDWHACDLFPKSWIDLVVVLRVKSEVLYDRLTERKYPELKLQENLDSEIMEVLLQEARDSYDEEIVVELQSNDAEQMDENVDRIEAWLKQWKENNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVA8</accession>
    <name>A0AAE0MVA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_537068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684110.1">
        <property type="nucleotide sequence ID" value="XM_062829067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVA8"/>
    <dbReference type="GeneID" id="87866221"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="507" mass="55785" checksum="4D275C0BA0F00483" modified="2024-05-29" version="1">MRLGPLTSQALGRSPYDEVAEGTGEPQPGAPEQLYDDRGRPVNPETRRINRDIIRSHNEVMLVIGVAEPDSGINEAQALYDAATKHQYYEDGIGRKLFLTGEVLATVGVWGVNGLRQRILLYKDSAHVPFSRLFYFHRSQQSWGEYIWAGLPSYVLSDSFAGFDMPEYPWVKYVFAWVNLHLDIFVFMQRTGLVNTSRWVPTLGFFIPGCYDSPIFLPKLPSSFTPGSIISWLGALVAGVAPFAGYWFFSKTYARLVWSLRRKIQRRLPKPINFSRRRTLKEVVPYLQPPSGTYNPPTPTPEEQQPQQQQRQEIQPRTPTPTQQQQQQAASANAIEAGWEMVHAPSDTLPTNDALPTGPPPDGTLRRQSTISVSGPGPGTPGNSQSQSQSQSQSQSQSPAATADEAPFLSDDDEETEHVNPTLITFDVDTSDSATSDSAPIPPGAAVWAAELRPNVPDNSSGSNRNSQQTVTNNSTTLGLDAPLYRDNGLTRLPHVLAAGALGLCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVC6</accession>
    <name>A0AAE0MVC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Golgi CORVET complex core vacuolar protein 8-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_7917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685683.1">
        <property type="nucleotide sequence ID" value="XM_062831425.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87868579"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="3">
        <location>
            <begin position="727"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="4">
        <location>
            <begin position="1270"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1517"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1543"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1586"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3354305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1667" mass="183590" checksum="042333A05216BC20" modified="2024-05-29" version="1">MSVNIPRRDEEGSVDDMMADEPDLGPTDDPSLSGDETIREHTVTAQDGEEVEEQPAAASPIAPTPIAPSAIANRYRELVEAEHDATTSEDGSTDGVLRSAASPLESFPTLSGDSPSVQGSVVSSPGSSNILPSLALRPGLRGPTPSFRPFDRRFSSFGSPGTLSPRPSSPAFLAGHSRTLSVTSNLLLDSSETETSSPPWEVVRWTKLLKLDGLAFSESGRRNFGSPTCLAVSTSIVLGTSKGVILVFDFNQNLKMIIGPGTKAVESGAVTSLAISADHTTIAGGHANGNIFTWDTTRPSRPFLSIPHLPQLQQRSTDGHVPDTKITHLGFLGTRHTALVSADDRGMAFSHLATRGTGSFGRTVKTTRILGRYPDAPPPVGKILKPSTVLAFQSLPLGNVDMATDTMGLTAMLTPYLLVIVSTTPVAQTQHKSARPKEVTAHSAMTGCLAWFPAVRLKVPDPLTGSNVSKVKLVYCWSNVLTVLEVEEEPAENKDKPPTLRFRPRNRWKCEEPIVAVQWLSRSVLTVLTITQRLIVLEDRTMRMTEAFDLIHKHIYHVDLFSKQLHTLVEQLDDEDPTMHGVVADAFYMSFKAYKGRLFLLGFTDVSLGALSNWADRLFALMESGDYVGAIRLATSYYTGDANKLTIGLPEDTALRHSMVIDKLMEIMSASLKYAFGQRTKRREAGDDKHLRELAENCFIASQNAGKTDFLFDEMYEWYEEAGLEGIFLETLEPYIIDGSITAIPPAVVKALVTHFVSNGLETRLEDIICHMDTSTLDLDQVTTLCKTHSLYDALIYVWNQALNDYLAPFIDLLALLVPLMQNGDVDGTASVLENEIRETNALKIFPYLSFILTGKTYPTGEKIPDAIAQKAKAELYWFLFSGQSIFWPKGSSKRLLTRPGQSQEPSFPYLRMILNFDAPSFLSVLNEAFEDSFLNDSPEKQLGGGPSRDLPEEEIFGLTVDRQYITSILMEIMNPADFAKEDTIYLDMFVARNLPKYPQYLLFTGSTLTKVLIGLCQYPGDDLAEDAQLSAEYLLSIYHPPDLPDLIPRFKEAGFYRILKRIYKADKQYGKLTLTYFEDPNERDAIFDCIELCLRPHSGLTRRQVQDVHQVIRDHAGKLVQIDSARAAQAIETYAPELHSHILDSVSEQPDLQYTYLKTILEPNKEMVNVRPPQQDLVEQYLQLMCRFEPSHVPEYVNKVQATNLRLEKLLPTMEETGVIDAAVMLMAKEGQVKEAMDRLTRHLETLESALHGLLTGTASQSQVDLNPQESAEELMQALQNYTRVGIWLCQEQTKATQESGNARQRHKSQPKDDLSPDEQLWLSLIESCVQITKRVTSALQPTPPPEDSTQGQLTNGGSHSNGESVLVSLDTEKLVTLVRSLVQNTFTTLLSSTSTRSSRSANTGDTPPAINANLSFLRILRAFLTRAAASSPNLADLRSVLSSIFAAYAYEESILGLSNRLLERSLFVSVNQAVQLRQRGWRPKGSTCEACGRRVWGPGVAGNVYEAWEERQAAEESQRQARKQQLTMGGGSKTSSGATAERGKGKDHDVWPATDGPQGGEEYNGSGNGNGKGKGKGEDVSSPRLKQQGESAKDQTQQANTSGHEGLQGPVMGKREQKLSPLVVLACRHVYHQACLDALEMKNGGAASNGDGLGVKRQYRCPIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVP3</accession>
    <name>A0AAE0MVP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_141574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685279.1">
        <property type="nucleotide sequence ID" value="XM_062820939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVP3"/>
    <dbReference type="GeneID" id="87858093"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="260"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="476" mass="51788" checksum="7279521E8D7FAA14" modified="2024-05-29" version="1">MKLRPCQVKSRLIRQALGRLRQPVEYCQILTTHPGRVDTRRTLTTSLNCLQLTTPTVKMATRRSARLSALAAAQPNGAAAPIVPPPAPKSRKRKVSAEDEGEPAPSSTTEPQLSSTPQKRKVSKKAAPPPATPTPAAAALLSSPAAQKPKPAAVSRLADPTKTNAPLLSPQTSRVVSSSPIRPRDTEEGLLSPSKLRAPDGKKDDNDTTTENILEKACAHLIAVDHRMKHLIDKHPCRIFSPEGLAEQIDPFESLVSSIISQQVSGAAAKSIKAKFVALFDDPAFSQEEAKEDDGQNGQDDAAHPAAEGEPTPTPTKRRFPTPSQVLAKDLPTLRTAGLSQRKAEYMHGLAAKFVSGELSASLLASAPYEELVAKLVAVRGLGLWTVEMFACFALKRMDVFSLGDLGVQRGMAAFVGRDVKKLKNGKNGGGNGKDKKWKYMSEAEMREISERFRPYRSLFMWYMWRVEETDVSSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVV7</accession>
    <name>A0AAE0MVV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Isp4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_28667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686282.1">
        <property type="nucleotide sequence ID" value="XM_062822952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVV7"/>
    <dbReference type="GeneID" id="87860106"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="801" mass="91114" checksum="BC59EC61C5151D8B" modified="2024-05-29" version="1">MLRNFFRRRHGDEDVMPDMVDDGSMEGDSTGLEALTALKQFEKMHRLDPNLPLDELDEVETALNSANIEKGTEIDQILAEDNSPYPEVRASVRNYDVEMPVNTIRAWTIGMLLCTIGSAVNMLLSLRSPSISLSTLAIQLIAYPIGLGWDLIFPDRVFTVFGIKFNLKPGPFNFKEHVIIVVMSNAAYGGGALYATDVILAQEIWYKQSFGWAWQILFGISTLCTGYGLAGLARRFLVWPAAMIWPADLVNCTLFYTLHDHSPSDPARTNGWSISRYRWFLIVMGGSFAWYWVPGYLFQGLSWMCWITWIWPENVIVNQLFGGQSGYGLFPLTLDWSIISGYLLSPLASPFHAIVNVVGGVTFFFVIVSLGIQYSNTWYSAYLPVQESHSYDNTGKRYDVLRILNQNLHFDEAKYHAYSPLYLPTQFALSYGLSFAAVAAIIVHVGLYHGKDIWNQWKLARHQEDDVHMRLMKKYRDAEDWWYIILFAIMLGMSFAVVCAWDTSFPWWAFIICILIPVVWTIPIGIIQAITNIQLGLNVLTEYVIGYMLPGRPLVMMMFKNYGYLVMSQALYFVQDLKLGHYMKVPPRVMFWSQLIASVWSAIVQIAVMNWALGAIPDICTDGQANQFDCPSAKVFFTASVIWGAIGPARMFSGKALYSSLQWFWLVGAIAPVISWFFVRRYPRSLWRYVNFPLVFGGSGWIPPATVYIYYCWGIVGTVFNFFIRRRKTGWWLQYNYLTSAALDVGLLLSTLVIFFSLTLSHTKAPEWFGNTVAGSTMDTTARAVQKHVQPGKIFGPHEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW43</accession>
    <name>A0AAE0MW43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_37095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686507.1">
        <property type="nucleotide sequence ID" value="XM_062823691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW43"/>
    <dbReference type="GeneID" id="87860845"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="161" mass="17622" checksum="85DE187A0629F0B9" modified="2024-05-29" version="1">MDASCQCGAVTFKTPLRHPLALYICHCAECRRQTSSAFGASAIFPRFPLPSEALLSCYKRPNPNGEFLECYFCKQCGTRLIHSTAGKNFVSVKGGCIEGLDWSKAIHIWTKSAMVPIPENATSSEEECSVFDAFSSSQETLDQPDIVCGTTGERFSSKYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWJ5</accession>
    <name>A0AAE0MWJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_452469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686957.1">
        <property type="nucleotide sequence ID" value="XM_062826099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWJ5"/>
    <dbReference type="GeneID" id="87863253"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="172" mass="18723" checksum="107C28568EFAC028" modified="2024-05-29" version="1">MDFPLVSVALAYDPVATPFDRVKFQPLFDALPLFEKLVGLTEANDIRPPEERKPKEVGECLYRCGTATRADYEGRGLARALAAHLMVEAKKAGFKATQVGTVNNRLNEIWERVPGEVGAGDGAGVEGAKSTVVSVVDLERYEEEVVGSDGVVRKVNPFLGAKVLRKCIYVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXF3</accession>
    <name>A0AAE0MXF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_544307</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686405.1">
        <property type="nucleotide sequence ID" value="XM_062829284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXF3"/>
    <dbReference type="GeneID" id="87866438"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 16" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="15">
        <location>
            <begin position="169"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3355027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="358" mass="39945" checksum="2816B6394E0A0F48" modified="2024-05-29" version="1">MAASRTATRTLRALRTSTRPALTAAPRAAFQQGGRRLYSSEPAKSGGSNIWAWAIGAGALGAGGLWYLNQDGASATPKVFTPKFEDYQAVYNEIASRLEEKEDYDDGSYGPVLVRLAWHASGTYDKETKTGGSNGATMRFAPESDHGANAGLKAARDFLEPVKAKFPWITYSDLWILGGVCSIQEMLGPNIPYRPGRQDRDAAACTPDGRLPDASQAQDHLRNIFYRMGFNDQEIVALSGAHALGRCHADRSGFDGPWTFSPTVLTNDYYKLLLDEKWQWKKWNGPKQYEDKKTKSLMMLPADMAIIQDKKFKQWVEKYAADNDLFFKDFQSVIVKLFELGVPFAENSERWVFKPLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXN2</accession>
    <name>A0AAE0MXN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_67774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687485.1">
        <property type="nucleotide sequence ID" value="XM_062831264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXN2"/>
    <dbReference type="GeneID" id="87868418"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="526" mass="57093" checksum="0BF69A2C26B684E5" modified="2024-05-29" version="1">MFSPGNGGPPLQQPPPPGPLAPGPGPLSAIPHLSFSRYRRNVDIRLDAPVVQVARGTLPSHHRVRIGTVVGGLRRRLGGEAAAGVDTRPDYFVDPRVGNDDHDTDAKDTEPQPFETFPHVVNPPAPAGTVISVTMTPTSQATSTPQPTSPTSASPMSQQTDNNTECRLLGPFAILVQIALGCLAISSLVYKRWRERPQRPVKIWFFDVSKQVFGSVLVHAANVFMSMLTSGKFEIKVLDPVAVAVGTKMVKRAVEYGILNARGEDEYTPNPCSFYLLNLAIDTTLGIPVLILIVRLLSRGLTYTPLGQPPESLQSGNYTPLHSPPGTKPRWGWWFKQSIIYFIGLLGMKFCVLIIFMVFPWISRVGDWALGWTEGNERLQIVFVMMLFPLIMNALQYYIIDSYIKKEEKIPEEGAESEGLVTGRGDAEAAGAEERRGSVYDVISGSDEGGNSGSDSDGEELPKDKAAEVGKKGAKTKPKVREEEYDPAVDGDTPTVIGSSSSAVSGVSGSIREERIKESASLISHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXU9</accession>
    <name>A0AAE0MXU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_48747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686840.1">
        <property type="nucleotide sequence ID" value="XM_062827703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXU9"/>
    <dbReference type="GeneID" id="87864857"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042017784" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21169" checksum="9AD8C3B0B57531B9" modified="2024-05-29" version="1">MGPITTTLTALLSLTTLALAESPAGTPRINSISYSGSGCPQTQAKFSGSLNDPTLTFNHFAIEYPNTVNRTANCQIHLQPKGVSAGWQVSVKDTFVDGHVTLDPGAALDYFSTVYFSSSADNSATSKGTLSNDGSARIDKAVTLQNHFTDRAWSSCTTSSDDGFGILNINFRGALRNEKSYFEATSETWDFEWRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZW1</accession>
    <name>A0AAE0IZW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_81682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676542.1">
        <property type="nucleotide sequence ID" value="XM_062831449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZW1"/>
    <dbReference type="GeneID" id="87868603"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042278404" evidence="2">
        <location>
            <begin position="21"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="4">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="652" mass="72449" checksum="91768770F25DDB2B" modified="2024-05-29" version="1">MRLINTTTLTLTSFMVPVSSLPAYAILSHTWYPSPDEEVTFQDFTSLPPHQLEKKKGYAKIKQTCHRAKKSGIKWAWVDTCCIDKTSSAELTEAINSMWAWYRGATVCFAFLEDLEPVPKGVGHGHGQGQNARNSQIVGEQWWSQIGEQWWEDGGSNVGSSNAGSNVSAATGSGTGSATSSHTQAGRMDHLSHEEKVARFRTCRWFTRGWTLQELIAPSRMGFYNSKWEFVGEKSSLKQVLAEITQISESVLENSALLLTIPVAQRMSWASSRVTTRPEDMAYCLLGIFDVQIPLLYGEGEKAFIRLQEEIVKETNDFSLFAWKTGKGSGTQHQKHWGILAPSPKEFATCRDIENWGNPLYNAECLITSKGLRITPAPGDGLRSGSSSYGLKGTYILDLGCYHRSEKGRAIGVVLQQHGSDLYCRVMPESLPMWPTGPGQQPVLRKSRLFYITKTVSPVASTLLGSSHRWAFDLSQVFAALAEIKFVPKQSQFQPEESWDAERMLFLSQGSRDFQCCATFVTTRKDGLGALRILVWCHLHLVHGGEGEAQASVKVEFDPPTEGETDDDGFVKCEGKVVRDAYEGQPVFRVLIEATTSKFRALPTIMFFRGTDEKMARKNQMYQQQKVAAAAVGRERYFNSAAASMSSSTVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0F6</accession>
    <name>A0AAE0J0F6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_84980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000016">
        <property type="protein sequence ID" value="KAK3334257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676423.1">
        <property type="nucleotide sequence ID" value="XM_062831481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0F6"/>
    <dbReference type="GeneID" id="87868635"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF111">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_1G10100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18735" checksum="29B3E12A3677B290" modified="2024-05-29" version="1">MIPNVKVDDFTETYRVNVLGPLLLVQAAQPYLPKDRSGRIVNISSVSSSTGFVGQSVYGGSKAAIEAMTRTWSRELAENCTVNAVNPGPVEGPMYASNSEEFLEGIEGWIKHTPLMKAREDLHGKEAVEEAKQWHGRLAKTGEIAGVVGMLCGEEAGWCTGQVVCANGGMLMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0J2</accession>
    <name>A0AAE0J0J2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_79585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676481.1">
        <property type="nucleotide sequence ID" value="XM_062831428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0J2"/>
    <dbReference type="GeneID" id="87868582"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042145204" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13203" checksum="C8BFA400035859EA" modified="2024-05-29" version="1">MIHKAAFPFRQTVLLSVCLIHFTDCAPCPLIVASLPCLSRAHRFCYTSFEAQQPSNAAIIRRYPHAKHGHRYRPQAPETMVKRLADKCIRNTLGGLTAMYHPSGRACMYHHSLREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0Y4</accession>
    <name>A0AAE0J0Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_480367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677084.1">
        <property type="nucleotide sequence ID" value="XM_062827572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0Y4"/>
    <dbReference type="GeneID" id="87864726"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="92" mass="10257" checksum="541FF0A4B814A8E5" modified="2024-05-29" version="1">MLLRPLPLPTVAAMSCPHVNALRCPVPVTVKQCVSMCFCQKQAGAGRHVIAAVAASWPSMSCIWHPRHVRPWHYGVEHVNDVQFFCSSDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J205</accession>
    <name>A0AAE0J205_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_436149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677231.1">
        <property type="nucleotide sequence ID" value="XM_062825226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J205"/>
    <dbReference type="GeneID" id="87862380"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF14">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="306"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3335065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="838" mass="95074" checksum="4C1AEA635ABD0881" modified="2024-05-29" version="1">MPPVSISLPSHVAQPSPKTCSVTVTSIPLTSPSNTEPNLCSFCSLIDFSLLRYPTTTDLLSLNDGNPAPQDLSPFKRNPYAKVEPTWSLGLLSRIHKSSSSCDLCHAIRTVLDQQPHVRATLTNMGVKDPLVLGTVALCGRLSAPEGASWLEHDDKYGGLKERDCFFLRRLGLLFRPADKDEDVNVPGMAKKIESWFSVMDSFQTMNTAIPRGFEVGAEDRKGVLMGDEENPETVWFAGRKRPEMIDIGLIKQWLGECLEKHKDICGISEEVDEDDDPDLVEQMRRLSCIVTKYNLYDVDMSALKFASLSYVWGVTPQKLVLLIENEYELQRPNSLVGKVSKTISDAIHLTEQLGLKYLWVDALCIIQNSDDDKVMQLGNIANVYAHSLFTIIAAAGDDSNFGLPGIRTPRDAVQEVVPVIPPSDTNPGMSLITALSPTHQSHEHPTRKAIWASRGWTLQERALSRRAIFIMKNHVLWSCSRSHYSEESCCETDTLGTLAWFGLQESDPILNSSERTWYTEDVPEEQVWYKFQRLVQDYSGRNLKFQGDALDAFSAVVEQVRRMTGENFLWGMPSGRFELCLCWEPYRRGLKRREELSTLEMTSFKRHVPFPSWSWLGWSGAIFLKVQDRELEVGLNPKVVCFVLRNHPLRVFPVRRISVDNDPERANSWAIPNVTDSKYSVTLDDIYDNLPSMTPEVLLDTPDDQLIFFWTESARFKLSELKVQGPSILQENPLQVKEYTKYYREILDDDGQVVGRTHPCDPTAQEIGVDEKGDGKCEFIRIANNYLPFCDPEKLVMQLRRGTGKYNKDVRYRVNVAEIKKEAWKQVYEKRVLVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J2D5</accession>
    <name>A0AAE0J2D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_583266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677107.1">
        <property type="nucleotide sequence ID" value="XM_062830874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J2D5"/>
    <dbReference type="GeneID" id="87868028"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="419" mass="47964" checksum="A09753A5D606C230" modified="2024-05-29" version="1">MKDSELLELLDVDGSGTSEQCKWCALSYVWGGDVPLKTTKATQLAHKERIPLDTLPQTMKDAVYVCRGLGIRYLWIDALCIIQDDQEDLREEVNHMPEVYQYATLTICAASSTSIYDGFLYRRGYWTHGCHAMNVRIAIDCSESIVLLSCSTSWYDVVHEYTTRAASLASDKLRALSAVARVYHLETGKEYLAGLWKEDIPTALCWGNGPKVRRGSGPFLTSQRPREYRAPSWSWASIDTPVRYWHEDRGALLKMRKLQVLSASITPTYPDGEFDSIASAFLVLHGSVRAVPLTTPIELQEFRTEDPTYRFSCIWVAGVRARVYPDAFEDQHETLDTLRFLLLTEYNHSHHPNIRFKGRYMTYRGLVLKSVQAQSDTFSRIGHFETEIDEPDSRLPDYLKAWTHAKFFDSFEDRTITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6H6</accession>
    <name>A0AAE0J6H6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_511800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677288.1">
        <property type="nucleotide sequence ID" value="XM_062828524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6H6"/>
    <dbReference type="GeneID" id="87865678"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3337837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="375" mass="40998" checksum="F16AEFCF4E37DF64" modified="2024-05-29" version="1">MAVGTVLVTGGTGYIGSFTTLALLDNGYDVVIVDSLLNSSEAALDRIELICDKRPTFYQVDITDEAGLDNVFSKHPEIDSVIHFAALKAVGESGEIPLEYYRVNVGGSITLLRSMAKHNVPNIVFSSSATVYGDATRVPGMIPIPENCPIGPTNTYGHTKVMIETVITDHIEAERRKAKKAGKPFEQWNGALLRYFNPCGAHPTGIMGEDPQGVPYNLLPLLGKVATGERDKLLVFGDDYASKDGTAIRDYIHVLDLASGHLAALNYLREKKPGVKAWNLGSGRGSTVFEMINAFSKVVGRDLPYQVVDRRLGDVLDLTANPALANEELKWKTKLTLEDACADLWRWVENNPKGYRQDPPAELLEKLKASKAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6K3</accession>
    <name>A0AAE0J6K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_306264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823217.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87860371"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="306"/>
        </location>
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            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
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            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3337867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062823347.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87860501"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="14"/>
            <end position="186"/>
        </location>
    </feature>
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    </feature>
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            <end position="178"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3338183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="262" mass="28721" checksum="6F7A60A5CF74ADC3" modified="2024-05-29" version="1">MVIPDYFTMFNQRIWRQEAQGEEPQQQPTPSASTEPQQNAGAQQQTTPRDGSDSSESSLHIVEDYWFGPNSPSRNDQQKSTSQQPPPQLLPYVEDPNAIELENINPQQASGAQLQKTPRDGSDSGESNLEIVKDYVENLPQPPPQLNPNAAEDPIAIELENINPQQTRAGGNQQQQVQEPPKADDGTAINIEVRGFAGTLVLRFLASFCISNTKNRQRRENFAPAQADGGGDDVDGDIAPDLGPPRPPQDLPVKGYIFLCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7J4</accession>
    <name>A0AAE0J7J4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">B0H65DRAFT_434319</name>
    </gene>
    <organism evidence="4 5">
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677458.1">
        <property type="nucleotide sequence ID" value="XM_062825122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7J4"/>
    <dbReference type="GeneID" id="87862276"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF12">
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    </dbReference>
    <dbReference type="Pfam" id="PF09362">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="15"/>
        </location>
    </feature>
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            <begin position="16"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="290" mass="32548" checksum="332B802970FB3C29" modified="2024-05-29" version="1">MRLLSALLLAETASALTDIEHKPFMRKNIDPIVSPGKYISHMHSFYGSDAITKDLPTTAQLQKGCSSGENPNDLSIYWAPTLYYVSGNNTYTEIYPATFKTYYEQIDHAEIPFPANFHAVAGNASARSQSDVDERVTALTWWCDGNGPEDRNSRPRAAFPRQTCSAHMQAILRFPDCVNPDKVEEYAYAAQNGGRCPGKMKRMPSLRFSIGDGYCFHGDFINGWFEDAAQNMLKAKGQTFMRIDGAHGNGKQYSKCKARDADPENGTSDYLKSLEMMHGHMKKKERTWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7V3</accession>
    <name>A0AAE0J7V3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_445807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677317.1">
        <property type="nucleotide sequence ID" value="XM_062825770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7V3"/>
    <dbReference type="GeneID" id="87862924"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3337866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="260" mass="29051" checksum="F41A08DC7A2D44A9" modified="2024-05-29" version="1">MYYQTAGRQDHLHFTTTKKSSGDLPGSRNRSRVVQSRPSQAGNVKEEVSYPPVVLACDRPENTVEKKSPVHIDWVRPKIAACPRELPCRMLTPFLQAADQHHLGLGSHIPQTDLVSPFGTLVGLELYDHDDEVWEEAKVPAAAKASKGGLKAYINERCAYRGIDLPYPDPEDDNEHAENTNTNNNYNNHYHTRKRRRVESPAGDENRASAPGRQNNIVVDAVVDVFLEGSSDEVDDNQDDQAALSYEGSDDDLDDDQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678136.1">
        <property type="nucleotide sequence ID" value="XM_062825012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8U5"/>
    <dbReference type="GeneID" id="87862166"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="50" mass="6051" checksum="BCDBDFEEA4F1C475" modified="2024-05-29" version="1" fragment="single">IIRSLIYIILGIRLNIVYIIPIFARYITNPIKVYFYILKKVFIYSKSIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J948_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_541750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678251.1">
        <property type="nucleotide sequence ID" value="XM_062829187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J948"/>
    <dbReference type="GeneID" id="87866341"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
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    </dbReference>
    <dbReference type="Pfam" id="PF06985">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3338891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAR3</accession>
    <name>A0AAE0JAR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_580944</name>
    </gene>
    <organism evidence="7 8">
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678862.1">
        <property type="nucleotide sequence ID" value="XM_062830806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAR3"/>
    <dbReference type="GeneID" id="87867960"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000017">
        <property type="entry name" value="Multisynthetase complex auxiliary component p43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="6">
        <location>
            <begin position="220"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3339502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="46795" checksum="9AD666050508AD49" modified="2024-05-29" version="1">MAALDTYKYTPAEEKEVQQWIQKADTIKASDDKQSVLDALNADLATRTTVLGTKPSKADIAIYEAVAPLVKAWSSEERTGQQGRPNIVRLVDFVQNSPLFGLNVADADKIAIDADEILYVKPPVDAKAEKERLKKEKAAAAAAAQAAVSTVQGAAATVVDRTKEAVAAVVEKAVEVKDQVVQAATDAAPAAAAPKKEKKEKKVNENRRPKAAPPPPAPLSPGLIDLRVGHILKAIKHPEADSLYVSTIAVGDAPGTEDTAEYEGQVCRTVCSGLNGLVPLEEMQGRKVIVVCNLKPVKMRGIKSCAMVLAASPKPQEGVEDDHKGPVELVNPPADAKAGEKVYFEGFNAEPEKVLNPKKKVWETFQPGFTTTGALEVAFDVDVCKDVKDLEGKSGIAKLVTASGGVCTVPTLAGAQVMIELMTLFKPCDFHGLLRVRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAY5</accession>
    <name>A0AAE0JAY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_528682</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679271.1">
        <property type="nucleotide sequence ID" value="XM_062828899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAY5"/>
    <dbReference type="GeneID" id="87866053"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3340329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="417" mass="44996" checksum="1C92D023E41190BE" modified="2024-05-29" version="1">MARAKQPTPVRREVSSEYISKADRKSPTGEEAVVVSGADGSVKPSSSSSSSLAVPMKKEAGVVTLLIDVAGIYISFLTWAYLQEKLTTTNYGASSFSKGERFKFPVFLLTIQSLFAALGGKLFTVLSTPKGQPVPAMIPSRAILPPLLLVAFTNALAAPFGYAALGHIDYITYILAKSCKLLPVMFLHITLFRKRYPLYKYLVVAAVTAGVAVFTLHSGSKKHKTSSSHSGQTSWGLLLLGINLLFDGLTNSTQDYIFQTFQPYTGPQMMMANNLLSSVITGGYLVLSPWLVKTGLGEWFGMAQATGSEGELAGALAFLARHPEAWRDVLGFAVCGCVGQVFIFHTLSTFSSVLLVTVTVTRKMFTMILSVVAFGHRLSQMQWLGVGLVFGGIGVEAGIARREKLAKEEAKRKAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAZ9</accession>
    <name>A0AAE0JAZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_431582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679303.1">
        <property type="nucleotide sequence ID" value="XM_062824950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAZ9"/>
    <dbReference type="GeneID" id="87862104"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="179" mass="19088" checksum="8340008894D1E915" modified="2024-05-29" version="1">MAKSLPDMVELISSPSAVKSPDSDVSPRTQNSSKPRDYFSPQAKAHSSDSENQTPAVDYRAATTSPTSGTSASRRASIVSPLSLADSFQDESRRTSQSGGSSSDRPPVGSRKSSAVSISFQAPRHPALPQGKPRKTDNRRLRASSPSPVSHDQSALQLAVLRKESYVVAALDYVTSATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB80</accession>
    <name>A0AAE0JB80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_444460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679396.1">
        <property type="nucleotide sequence ID" value="XM_062825683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB80"/>
    <dbReference type="GeneID" id="87862837"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="123" mass="13496" checksum="E5EEDE5DDFDCD648" modified="2024-05-29" version="1">MPLNFLRLRLRATWFSLGILGNNSWTFLGCLGCLGCLQVLELLGSLGHSWKALGRFFLIVLIVLDSWLTSWTLYSTLGCLGVLAKRLESSNQSPTQRDSTSAGGAVIKAVTQSHKQSQEVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB87</accession>
    <name>A0AAE0JB87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Catalase</fullName>
            <ecNumber evidence="4 12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_269394</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 19">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679689.1">
        <property type="nucleotide sequence ID" value="XM_062822732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB87"/>
    <dbReference type="GeneID" id="87859886"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00328">
        <property type="entry name" value="catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="9 12 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042224624" description="Catalase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="56"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3340747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="720" mass="79308" checksum="8E6D175EDE1C2C36" modified="2024-05-29" version="1">MRVNALLPLSGLIGTALAACPFADPSALGRRAEGGEVDARERLKEVEVDDNGQFMTTDFGGNVGEQFSLKAGGRGSTLLEDFIFRQKLQHFDHERIPERVVHARGAGAHGIFTSYGDWSNITAASFLGAEGKQTPVFVRFSTVAGFRGSADTARDVHGFATRFYTDEGNFDIVGNNIPVFFIQDAIRFPDLIHSVKPSPDNEIPQAATAHDSAWDFFSSQPSTLHTLFWAMSGNGIPRSFRHMDGFGVHTFRLVTEDGKSKLVKWHWKTKQGKAALVWEEAQVLAGKNADFHRQDLWDAIESGNAPSWELAVQLVDEEKAQAYGFDLLDATKFLPEEFAPLQVLGEMTLNRNPTNYFAETEQISFQPGHIVRGVDFTEDPLLQGRLYSYLDTQLNRHKGPNFEQLPINRPVSGVHNNHRDGQGQAWIHKNIHHYTPSYLNKGYPAQANQTVGRGFFTTPGRTASGLLNRELSATFDDYYTQPRLFFNSLTPVEQQFVINAIRFETSHVTNEQVKKNVLEQLNKVSNDVAKRVAVVLGLEAPQPDPTYYHNNVTRGVSIFNQTLPTIATFRVGVLSTTKGDSLDKAKALKEQLEKDGLKVTVVAEFLAQGVDQTYSAADATGFDAVVVAEGAERVFSGKGAMSPLFPAGRPSQILTDGYRWGKPVAAVGSAKEALKSVGVEEKGAGVYAGAQDEVVKGVEEGLKVFKFLERFSVDGDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBM0</accession>
    <name>A0AAE0JBM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_498535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679606.1">
        <property type="nucleotide sequence ID" value="XM_062827814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBM0"/>
    <dbReference type="GeneID" id="87864968"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="754"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="787"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3340664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="908" mass="101079" checksum="EA39388AE3A2AFED" modified="2024-05-29" version="1">MANHPIPDLSTLLSSAQIFSANYPLPHIRAIHKALHAEIDDKQSRLRTQVGGSYRELLGTADTIVQMRGDMESVQATLGRMGGRCGRQVVKEKMDGLKKWDEAEDMDNTRRREAARVKILEGCVLAVQKLLRREEKGPGRDTRKMRGGKVEEKEVVMSKGDKLLVAAKVCVLGRLLVKTFEREGIHNEASRTAVKSADRSLTVLRDRLLRCIDSVLVSINEKLTPRSDLLKALSAYSLHTSSGARDTLRHFLEVRGSALSWEGQPSAVRTPKDILRRLNLYAKTLQDVQALAPNKLADALNGLKKKALLADDSLRAIEGLRLDTYSRWCGDEIRYYTPFIRHDDLQAESVNSLLFEWAPVHRDVFIDDLDKTVKSMSEFKAIVDLRTSVLRLWIAESSRVRFNDFSPKDEQHSDDGTPINSSMFSQIRSTINNHLLSVIDSKVHKLRLVGSEASAALAAWREGTTDQHLSLWDPSTFSGIDLTIPSGPSGGAAQQFASEVISRLYGRNDAVSKAVASYKSWFHVIDDVGSVVDQLRRQRWENDLEDEEGDMMVVEDEETIEQRQQLLSREDPERLTTHLSDSLLKAFAALDEHLTDLWNQQREGPNNGQIAMYLLRLLRDIRSRLPTEQQQPQIPPGAGASEEGSISSIKAFGLPTIPSLHSSLARTVLVSSVDEFVTVALARKTVVGRALWEGSPELPTSPSPGMFRFLRNLSAAMADAGADLWSPAAVRELKRAVRGEVCRVWLEAARGVLSEGEGGGEGDAEKVAGGSDKKEDEGEKDDDEEVKEVKEEGDNSGEEGKEGNGEEAKTEEDKPSEEQQQQAKEEAEKLKKQEAAEKANQQRRDLFVQWLFDIIYLGIFLDGSKGDFNEIANTVFQHSGLDPGAKGRLVKAAQEYYKRTQLLFGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBQ2</accession>
    <name>A0AAE0JBQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_551368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679913.1">
        <property type="nucleotide sequence ID" value="XM_062829803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBQ2"/>
    <dbReference type="GeneID" id="87866957"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="147" mass="16692" checksum="35B0B36E7B5776F3" modified="2024-05-29" version="1">MSWSQKTFSLPAQSRGAYLITDIVMNEVPEIKQYKVGLLNLFIQHTSCALSLNENWDPDVRLDMSDTLDRIVPEATDKNPDLYRHADEGPDDFPAHVKSSLIGTSVTIPIKNGKLATGTWQGIWYLEFRAHKHRRNIVATIQGEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JC48</accession>
    <name>A0AAE0JC48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_219205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680230.1">
        <property type="nucleotide sequence ID" value="XM_062822029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JC48"/>
    <dbReference type="GeneID" id="87859183"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="911"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1016" mass="108684" checksum="59690E6B6CE55886" modified="2024-05-29" version="1">MALAGVFKSLGATNINSNYSISSTLTTTAGPWKIYPAKKKSTGKEYSVFVFDRKILDAHSKDLSRSSAAGFKKVVEEVVERLKKEASSLARLRHPAILELVEPVEETRGGGLQFVTEPVTTSLAAVLQEKDDQERNHGVGGRSSRYVREEPDGTRRRREVEIDELEYQKGLLQVSKALEFLHENAGLVHGNLTPDAILINAKSDWKVSGLAFCSPQQDSNKPTSIQPISLSEVLHYEPRLPRTVQMNLDYTSPDFVLDNNLTSSADMFSLGLLCISLYNSPHRSPFECNSSLSSYKRHFQSSQGVPSSTNNYLCSRELPKELANHVLPRLITRRPATRMTAKEFQQSEYFNNIMVKTLRFLDTFPAKTPNEKQAFLRGLIKVLPDFPNSVMEKKILPGLLEEMKDKELISLILHNIFKIVELLPSTAGKRAFGDRVRPVIKEIFVTNAKQAQERDPARDAGLMIIIEQLHVIVGACPGKEFKDDILPIIFAALESPTPVLVGAALQSLPSVLPVLDFSTIKNELFPVVAMIFSKTNSLAIKVRGLQAFVVLCGGSTDPLANNDGLDGLGPSERKPSSSSSALDKFTMQEKIVPLIKAIKTKEPAVMIAALNVLRIVGKVADADFVAMEILPILWAMSLTPLLDLRQFQSFMDLIKSLSKRVEDEQTKKLQELNGGNTSGPAEDFMSLGGLSGSSALDTNGTSANDFAALVGGGGNTNNNTSPLDSGGWDNALTSGSKPPVTSPGVRSGTGTGRSTPAATFSWSSTPPATTTAPSTTLKPQTTGSNFRTVTPDLNSFQALTPQSTQFSQPLQPTPSTITSPTGIGINWGAATQAQANPWSSTPASTVTSPSIAPPTNAFGNMNLGQLSSNSRTSSSFSLQPPPSASAVSTPGFGSGTGGFSLAPPPKAPAQSGAPTTTTTTWGSGSGSFGNLSLGSINNGANSMGNMMAAKSNTGGMMGSGFGGMGGMGGTSMGMMQPLQPQSSGWGTPLQPQQARAQQQHQQQQNKSGLDKYESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCF8</accession>
    <name>A0AAE0JCF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Domain found in IF2B/IF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_444722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679702.1">
        <property type="nucleotide sequence ID" value="XM_062825696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCF8"/>
    <dbReference type="GeneID" id="87862850"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
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    </dbReference>
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        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="257"/>
            <end position="419"/>
        </location>
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            <begin position="148"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3340760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="425" mass="47892" checksum="14DB3D73C4BA8EFA" modified="2024-05-29" version="1">MVALINVRRDNPDPFYRYKMERIQTKIEGKGNGIKTVVVNLSSVAQSLARPGGYLIKYFGFELGAQTNIDPPDDRWIINGSHEASKLQDLLDGFIAKFVLCKKCKNPETVVQIKDEKITLDCKACGQRSKVEPQLKLTSFILKNVPKKTKKDKAERKAARKARQNGGDKDGSGDENGSDQASPAIEDKNIEYASDDDELTRKIKTEAQSLQLDRREAPKEEEWAVDMSEEAVRARQQNLPGEFKQKLVLNGEEDEEEEGGNTVYDQLGTWIEDEAKAKGGITNVDDVDIYVKAKELGIDAKHRTVQVLVQCLFDENIVAQIPKRAPMLKRLITSERHEKALLGGTERLLADLGKESYDKIVKILQLYYHHDLCSEEVITKWGSKASKKYVDGSTSKKIRKAAEPFLTWLAEAESEEDSDEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDK9</accession>
    <name>A0AAE0JDK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_527814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681012.1">
        <property type="nucleotide sequence ID" value="XM_062828880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDK9"/>
    <dbReference type="GeneID" id="87866034"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
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            <end position="282"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="351" mass="39988" checksum="58B924CCE0627063" modified="2024-05-29" version="1">MSEGSETTRIRDEAVPAVGQAAQGSTALKRSKKGSPYYFRGTVRIAPSREAALREALEAMKFVSTAQKTQLCIFADGSFDQTTKDGGYALAHTGFAPAPSEASVERQVAKGWSAIPVTNSPTCEGLAIAQSFKEAMKELTILEKRVATRPVDTASAGGRMEASVITFSDSKTVLEATKRGKFPKSMKHMGHAIIKFSEELKEKFRGPRSRLKVNLVVHWIPGHYHTVMPLHSNGADGVYEEVKSAKRYKEERLMQWREREQQEWEEPQSHQPVEEDQPEGQQLYQQEWHNQMQQYYQQNANYWQQLSRWQDWQRAHGHQAGQWYWDGNANQWVWQWDYQRPGETGNGQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEE2</accession>
    <name>A0AAE0JEE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_524105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681435.1">
        <property type="nucleotide sequence ID" value="XM_062828815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEE2"/>
    <dbReference type="GeneID" id="87865969"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="415" mass="46807" checksum="A283E8758250890F" modified="2024-05-29" version="1">MPLHLLGKKSWNVYNTDNVARVRRDEAEARAREEAEEQRMQQVDAERRLAILRGEVPPPLEEPPAADSSNHGRRHRERDPLTEGRKRKRAGEDDTDYEMRVARERATAGESAARELSGPVKSTSITTASLVDSRGHITLFAEEELKLAEKDEKTETEASKKKREEAEQHQVRFTSAAGRDAEGLLAKNGPWYATPDGDVAALVPSKNVFGKEDPGRKAREVERLSASDPLAMMKRGAKMVRDLNKERERENEERERELKDLRKEERRREKRRRTEHRRERHDSREPGGNETITETDREIETATVSVAMTATEIVNGVAIMRKGRETATENEVVSVKETGKGEEITLVTGTIDGLARSGTTASIATTEIAMVMMVSMIIINIITDQKGRVTRTSQDMEEVIAHNILIFFQFPTFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEE6</accession>
    <name>A0AAE0JEE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_573074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681354.1">
        <property type="nucleotide sequence ID" value="XM_062830533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEE6"/>
    <dbReference type="GeneID" id="87867687"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33315" checksum="87D50249BACE44F5" modified="2024-05-29" version="1">MASFMNLLPVETVNHIVQYLGTSDANRFGQTCKGAYSITNPIVYKDNVPAKTKRGPVTWGVVTGQLRVIEMAVAAGADVSAPDSLDKTRSVELGVNAPSSNPFTDGMMGCMTYMKANALSKGELLGNCTGIVWTLEFQKRDLPHRHMLVLLDAEIQRTYLESEVGNMLGFGIRLYIRGLVLAVSATRHIVRTYTLPVTHGVACVQTELVPKKDVNPALPPSWMLAGEGVVGEEPLEPAQRLITHPQTPPRPVLYSWTWEESRHCSREHRSTPSHEEDASVSTFADLTGASRARANVLLQSGICSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEL3</accession>
    <name>A0AAE0JEL3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_548415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681238.1">
        <property type="nucleotide sequence ID" value="XM_062829581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEL3"/>
    <dbReference type="GeneID" id="87866735"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1249" mass="137925" checksum="34DB571D68B120D5" modified="2024-05-29" version="1">MPGTSLPTYQEATRTVDWLELAGPSISIRDYARLCRVSRHFCDYFLPRLWTDPFAICYALEPTTRLDGETPRTELFLRTVPDTRLSTRSLVFAFTPRIRDWLFMLGRYPETYSPSSWFANLRCMTLIDCPPPNDHEHIIQFSASQFPTRPYVVAAVRCSRLPVQWPASKRFREVVYFDDSRTHQSGPTRPRFQGMHRLRILRATGHNMGDSGAAQIFHDLGRRLWSLDLSNNRLTNRFLQNVVQSDKLRGRSQLGNRHEDGSCICFGRGHHHELEGSLCSSGMGLFIHETPWTEDLRLYHSRRYHEDSPGYVFRANPEDANAESREVRKRALDDSLDAVVKAICSEKDVSSIHSLDICQLPLLGITHLYLNQNPMITAEGFKLIIESGFEQLQRFECDSMLFITNGDMSRYNEYYHESRAVPSSVSGCKNQAISGILGLSHLFRPVFSNLQILRIHHSLVTNLPSLVGFDDLSAMEKIWFAETFLLPRADLVFPNPFYPDMNPRLRSLTLTHIPRYSTGPLIERLKGLLKAAWFQEQTIAKLRAEYRRVQSRYQPPLLPGLRKIILEFDPDPREKQGQGQTGTDGLEGFDAEALLNSGATEEFGTFGGFTRSSNSYGTSGPSTSSAVRHVNANNNGVTMFRRQQPQNSSELARLAAETPWVRAVLQSRHQQWPQEVERRAHEKLDWNQPIYVTSISRAPGKTKVFVGYHQDGHSRPVSINSTNNGVSSGLASSPVQDPYHPSQSPYHSQEQAREPRTSPSLPVSTHSLPPEPPAYTALPTPGPSTPLPLPASTTSTTSPSSLPPPPPPPSPPETPQLLTPIPPCYTSFPYFLSPEEKQASLTTYNLLLSRVLWLHPNSVHKKFSDPGYRPDPPAGPAGPAGFTASINAFSRFNASDVFGAYDGSSVGGPSAFEQRCKEELLRVLFHPIMAATPSMVRAGVPTQLLPKQQQQQLGQVGQGHGHGVRSEYLDHVLYNRLHDYDGERLARIRQAPAAGGGQQAAAEEDERLEESMDEQLLEETRRAERFQAQAAAESQDAGGQQPQERGGRGPVTNRHGGGQLDGRGGGSKDSGGRGMSSERKAAAAAAAGDDGDGDGEYSSSEGNIGTRDTSSTSISTSTSTSTSTTERRSAAAASKRDLLRKEMRRPTKEELKQMKDVIEELKKFRGLTGGGGCGSGGGSGHESKAKGKGKGKQKAVNGDGDGDGDGNGDDEGEEGEEDDDDDDDSKWAGKHWMGELKVIRKLPDGGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEU7</accession>
    <name>A0AAE0JEU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_465153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062826795.1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="101" mass="11244" checksum="E6C6B3D3585F11BB" modified="2024-05-29" version="1">MFISCIAPVLSALLQSCIYCIGTGRLRRMTECLTSSPWVPQEPPAGRFRSLHVCLLFHFASKSRSRTNTAEFSRTSTVSGLGRCRPPRNGHGMMVHLFTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JF18_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">B0H65DRAFT_573224</name>
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        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681416.1">
        <property type="nucleotide sequence ID" value="XM_062830539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF18"/>
    <dbReference type="GeneID" id="87867693"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3344803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="613" mass="66784" checksum="664E2CC88BAC1BCB" modified="2024-05-29" version="1">MNHRSKGQLMCRLEGCPHEVLFKAVDGGGYVDPLERRASGIRDRNNPLQGRGSPAGGPGGYGHQHRYSNAGADDETCTQLKPAHDSVCAYHARCPVPECNQARLQYLDPAYESRHSDTGPMYQRWEYCADHKCTIRRCPRRKQSAKAIYCKDHGCQADGCKSQRLDSKHNCCEEHQCKQDGCGTIVEGKFSYCAIHIKCDISNCNRARHNVSGTKDYLRFCTDHATCAVNRCTDLKIEQSLYCANHTCRERGCSKSSQSKPFCSEHCCAEVNCRSPRPWAASPNARGKFCPLHTCRAQDCPEFVDRLAIFCRTHGCSKPKCHEEVIVEGFCLDHLKAHYITQGELKARGGSSSSSKDSSTTLITRPGPGPVAANLQPPNFPRRLSQQSIASIRPGPGQRPTSVLLHGHAHEILIPPDEHPDELLDNHHNNPVKFLDHQHQAHVDDPDPDLDDDEVDDHLPNLNPSSLNSHLSHISHHINQSHQTHRSQHKQDYNNPHDIKETGSGRSSRSSEAVSALSDGGDIGAGVNGSLVNGGGSPGDPPEYSKVASSIVSVGQGHDGGEVTKTGNGGGGGGRGERERERNRRAEREGTGGGVPGSFGGEGLGKGEDSDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF73</accession>
    <name>A0AAE0JF73_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Snf7-domain-containing protein</fullName>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03357">
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="235" mass="26808" checksum="EC49C93F9B839784" modified="2024-05-29" version="1">MQTLRSFFAPPDPQAQMRKCNTLLRSNMRKIDRDIAQVKQVETKTKNLILAADRRAQKNPAQRKQAEKEVRDFARELIRARKTTARLITSKAQLNSVQMQVNEAFALRKIEGSIRASVKIMKDVNTLVRLPELAGTMQELSVELMKAGIIEEMVGEQLPIDVDLEDEEYEAEGEVDKVLGEILKDRMEKTGGLPSVPEPSQKLPQQPQHAEEEPEEEDTEAMMDQMRNRLEALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFT3</accession>
    <name>A0AAE0JFT3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="9 10">
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682137.1">
        <property type="nucleotide sequence ID" value="XM_062830100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFT3"/>
    <dbReference type="GeneID" id="87867254"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3345524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="325" mass="35464" checksum="8E63CA4A8F6E976F" modified="2024-05-29" version="1">MMFGSLITYQLLALFFVCLRFYGKRIAKAPWYVDDYVLIFSWFLELAYVFLVLWLAGYAGKGVPFEYLVTKDLNYLKDKLPTLLRLTPVMAMLGTVGTVAPKLSFLLTLLRLVIKPCQRLALWVSITLSTVTAIPLIFLPFFVCGLGYFPSLGQSTVCISPKIVFGYTGFACAIQIFMDLTLSIFPPMVVWGLNMNTHQKLTISFAMSFGIAKTALCSQLRGTTNPYKIAVVLVLSQAEVSASIIAACVPFCRPLVKKLTTREASKESNGSDGSTPPCRSVAMGGLAGCYRKAAGHRRLGSLGESESDGKRDGDCAGGYGPEMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFU9</accession>
    <name>A0AAE0JFU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_204531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681998.1">
        <property type="nucleotide sequence ID" value="XM_062821848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFU9"/>
    <dbReference type="GeneID" id="87859002"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3345385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="846" mass="93483" checksum="BEC40506324B857D" modified="2024-05-29" version="1">MKFSHSIQFNAVPDWSTHYIAYSNLKKLIYQLEKVVHLSSGGDGESRPLIQHEDPEVVFIRALDVELEKVLSFYSVKERELFEEVQNLLHDVGAFEEESGETDQERELRPPTRGSEHQRPLRTRSVESLPSRASTDDDRTNSDNSDDEHTGLNTHGKKRRASLGRRKISSAVPGHMMSSIGDMTASTEMTRSRRYSIVYDDDYAEQAALFSSGIMLKKRIINLFVQLCELKSYIQLNRTGFSKVLKKFDKIIDRQLRAKYMDTFVDTAYAFSPETTKGLEEKIHLMVRAYTDIVTNGDEEAATRDLRSHLREHVVWERNTVWRELIGMERRAEAASLGHTLLGRDADPTSHRLQGDDELVLPTKEIATPLGRFRLPAWLVSSTLMTLIIIFAIFFALLFIPVMKKPEQQNCLALLVFVSLLWATEAIPLFVTSLTIPFLCVVLRVFREADKPHHRLGAKAATDVVFSAMWTPVIMLLLGGFTVAAALSKCSIDKRIATFVLSKAGTQPRTVLIANMAVAAFASMLISNVAAPVLCFGIIEPMLRNLPAGSNMSKAVIMGIALASNIGGMLSPIASPQNIVAIGLMEPPPTWGEWFFIVIPVGIISLLLIWALLLLTFQPGKGTTIVPIRPVKDRFTGVQWFVTLVTVATIGLWCASHQLEAEFGHMGVIAIIPIVLFFGVGILTKEDFNNFPWTIIILAAGGLALGKAVNSSGLLHAVTRMITEEVKDFSLYGVLLVFSSLILVIATFISHTVAALIILPLVYDVGKGLDEPHPNLLVMAGVLMCSAAMALPTSGFPNMTAIMKEDPAGQRYLQVKHFISRGVPSSLLSLVVVVTVGYGAMRVVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG28</accession>
    <name>A0AAE0JG28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 8">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_425716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 8"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681637.1">
        <property type="nucleotide sequence ID" value="XM_062824594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG28"/>
    <dbReference type="GeneID" id="87861748"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="528"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3345024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="619" mass="69353" checksum="91E4B2917F3DD20F" modified="2024-05-29" version="1">MPDDEMPKEVAYRMIKDELSLDGNPLLNLASFVTTYMEEEAEKLMTESLPKNFIDYEEYPQSADIQNRCVSMIGRLFNAPVKDSEASSAVGTSTVGSSEAIMLAVLAMKRRWKNKRIAEGKPADNPNLIMSSAVQVCWEKATRYFEVEEKLVYCTPERYVIDPKETVDLVDENTIGICCILGTTYTGEYEDVKAVNDLLVKKGLNTPIHVDAASGGFVTPFVVPDLEWDFRLENVVSINVSGHKYGLVYPGVGWVVWRSAEYLPQELVFNINYLGADQASFTLNFSKGASQVIGQYYQLIRLGKHGYRAIMSNLTRTADYLAESLAALGFIIMSKKSGEGLPLVAFRLREDPDRNYDEFALAHQLRVRGWIIPAYTMAPKTEGLKMLRIVVREDFSRNRCDGLINDIRLCQGLLDQMDKETIKKQQEFIHKNHVASGKASHNHPKYRRHADHGYRRRNTRCRARQGRRTLSAESSPSRSDSGSDAGSEYDSEYGSDIDDYYKEDHKEHDLEREECPLCGSTSDIERKAEEEGIGDSDSATDDGTLVHGERHSQLDDRSTSSPVASMVAKTAYNHLTLSRHCGRKAAVRGKKQHQGKGAGQTFSLELPGGKKLLTPRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGG0</accession>
    <name>A0AAE0JGG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_200753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681862.1">
        <property type="nucleotide sequence ID" value="XM_062821781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGG0"/>
    <dbReference type="GeneID" id="87858935"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF8">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="142"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3345249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="486" mass="54137" checksum="41F79A9283066381" modified="2024-05-29" version="1">MALRLKRGQSLCCFPVPLPQMRAFASTSSATTKLLPLLPYRLLVRPSPNRPAHAHANAHAHQSGLSFHQRQTNTSLTKPTTQVREARSTSSAAFSLIATRQLRGTRNTTTMAGASASTDSPAGSDPLHPKVNMPRMVYGTAWKKNRTADLVYQAIKEGFRGIDTAAMKRHYSEELTGEGIRRAIKDGIVTREELYIQTKYTPHDDAFLAEPALYPTITSQVLASVTSSLRNLAHTESEEDTSYIDCLIMHSPFPDPVSTLECWTALQSFVPHRIRSLGISNITLPELQYLVADPRVTVYPTVIQNRFRRAERRWDYELRRWCANQNSTRWKGEKRTRYQGFWTLTGNRADWPTQKFVRELAMAVPKTAQEVEALEAEAAAAAETEEQKEGEQEGGGGLVDGEPAGTGDLLESGDGELGISLEAAWYALIILGADVVVLNGTTSQQHMRDDLECLERVERWKKTPQGKKAWDRCFEGFKALVGMPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGW7</accession>
    <name>A0AAE0JGW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GC-rich sequence DNA-binding factor-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_461021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682719.1">
        <property type="nucleotide sequence ID" value="XM_062826578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGW7"/>
    <dbReference type="GeneID" id="87863732"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="829"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="959" mass="107801" checksum="330E879E23EB2EF7" modified="2024-05-29" version="1">MAGLGGLNFDASKISKATAADYSSSDSDADDNDDFQVPSRNPHDDEFGDFNPRKRRRTGRDAKEAAALGIFGSESEDEGPRWKRKNLRTKGVSFVSSANNKPANSDEDEDDIGDEEDEDDEYDARPSMKAAHAEDEEEDEEEEEESRGVGLGFKGAAAAATGQGLGWVPPTQQQKEKSPPRQSFVKSTVNMSNPLGPGFTPTSAKAPTLLTKDDDEPPTRRVALPSAFAQAKGGKTKTNKMSFAARMMAKMGYEEGKGLGKEGQGRNVIIEANLRPQGAGLGAVKEKTLQEREEEKRQARLRGEELVDSEEEEKKKKAARRKKALAGGLGSGTASAGSTPRPKKPKYMTMDEVKKVAPGLNIPDAFTPILDMTGPGKKMLTTSSGLMTPTGTATPAESTEAAESRKLVKRAQNDFMAILEEWKSLQECKAYAELQLKQEQQELDELTASLQANRAITGLCEVLSIPVESGEFDKKADLDYKLRRTISGLLSASSSFSDAMLPQIKDEVTLLAVAAIYPALREYLQIWKPLEDPKPRFIDGLVSIRKLLGLDQKTKHTHRRAAATPYETMMYQLWLPAVASAVRVWDVREPDQLIAVFEAWDGLIPLFIRSQLLQDIVRKLEEAVQKWHPKKKSSTSNLPHGWIFPWLPYLPATHLDPKSSTGLVADVKRKFRQLIDVWEFNRGVIPGLKQWKEVLRPRRGSDQWGPLVMNHLLPSMARYMRKNFRVAPRDQEPYMDMLEGLFKWLQVIRPSMVGEVIVAEVFPMWHDALYQWLLLDTANYEQIGQWFEWWQDHVFPEEIKSLPSITAEFEKGMKMIERALDLGDRAKTELKAPERGPALPSSKSSTSRHEREHRHRERHREREAQAQAAAEEKKQPEEVTFRHALEDWCQENDLQFIPERKKMHAEGPYYRITARGDGKGGVLVRFKGDVLFVEVRGQDALKIHREPQSGWEALLELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGW8</accession>
    <name>A0AAE0JGW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_443054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682351.1">
        <property type="nucleotide sequence ID" value="XM_062825611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGW8"/>
    <dbReference type="GeneID" id="87862765"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042200441" evidence="2">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="109" mass="11660" checksum="EF099AF9902F1A3A" modified="2024-05-29" version="1">MRSSTLLAALGTAGLVAAQTTVTSVFVSTPTSTSSTPCHPHQQPPPVTFPPFPPPRAPIPVQPPRPVHSLPPPVVPEEFVVHGNEHKRNHEELPPRPHPPVHSLPPLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH85</accession>
    <name>A0AAE0JH85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_157202</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682915.1">
        <property type="nucleotide sequence ID" value="XM_062821176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH85"/>
    <dbReference type="GeneID" id="87858330"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042186319" description="laccase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="98"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="221"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="434"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3347833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="626" mass="68753" checksum="526FC2BD5A2D08C1" modified="2024-05-29" version="1">MKFFGIAAIVAGLLAPSLVLGAPAPGNEGRNLLTPVDKRQDFQAEGYGGGGGGGCNSPSNRQCWSQGYNINTDYELGTPNTGNTRRYTLDLTETDNWIGPDGVKKDKVMMVNGKIIGPTLQADWGDYLEITVINRLKTNGTSIHWHGMHQRNSNIQDGVNGVTECPIPPNGGSKVYRFRATQYGTSWYHSHFSAQYGNGIVGSIVINGPASANYDIDLGPFPLMDYYYETADRIALLTQHAGPPPSDNVLFNGFAKHPTTGAGQYATVSLTPGKKHRLRLINTSVENHFQLSLVNHSMTIISADLVPVIPRKVDSLLLGVGQRYDVIIDANQNPKQAGYGNYWFNVTFGGSGFCGTSHNPKPAAIFRYQGVPNALPTIQGVAPPDHQCLDLNDLKPVVQRSFNTNSIALNPGNEIPITLDGFVWRVNGTAINVDWNKPVLEYVLTGDTNYPQSENIVKIDGVNQWKYWLIENDPDGTISLPHPIHLHGHDFLILGRSPDANVSSQTRYVFDPVVDIPHLNGTNPTRRDVAMLPAKGWLLIAFRTDNPGAWLMHCHIAWHVSGGLSNQFLERAQDLKNGISNADKRAFNDNCNAWRGYFPNNDPNPKNDSGLRVISGVKAREVKLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHA3</accession>
    <name>A0AAE0JHA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_521830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682738.1">
        <property type="nucleotide sequence ID" value="XM_062828763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHA3"/>
    <dbReference type="GeneID" id="87865917"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="280" mass="31307" checksum="178E8440D016C56B" modified="2024-05-29" version="1">MSSNQQPPSTSPAQQVEEPTSNPTPLSNNTLFTTLCPSYELAFANIPARDSSLSWLLAQLAYHDTFPPHPRPWIHDALPPHLQRKRILDIGSGTGRPVCSALAEAGHSVLGIDLCPTMVEFAKGNVASLYPDGRAEFAQAKVMGARGVNREEGDPEGYHAVTPYFSLLAGFETRREIREVIRKVYHWFREGGLFVFATVPMDVEGEVIEWLGKPVTVSSLSRSQVLEVVREVGFEVEWEMTRKFAPKAVEAGILKPEEAEKAWEEEHLFVYAVKTWYPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHG0</accession>
    <name>A0AAE0JHG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_158689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682989.1">
        <property type="nucleotide sequence ID" value="XM_062821201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHG0"/>
    <dbReference type="GeneID" id="87858355"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="326" mass="35921" checksum="A0032D03BAED97F8" modified="2024-05-29" version="1">MTVNLDQVLFARAEWRFRFLAPCWMIQVGILLSLVGLFSYRLFVTSQTFDDEISHGQDPIVQIVWESTQVGFSFISATLTVAEVWKARSETLTPFFMLCTNLIKSTLASGMLGLDATVYVQYSNHHYSVVGLALDCILLGITLIMLFYAFYTYRRLLKFEAYDLAYNKSGGCSYSNGHGQDLGYTVKIFGGKENREPSPTPEALKSRIDQAIGAEFGWGSRPSGSVTERSGIVVASGSVQSGVPTRPAELHRARSWVTETGVAGPNTSAERVDANGRNTDDDYHDYYELAHARSLSIPTLVVTPHGEDGDSEALLTGQWRGADGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHH4</accession>
    <name>A0AAE0JHH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_159977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683024.1">
        <property type="nucleotide sequence ID" value="XM_062821221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHH4"/>
    <dbReference type="GeneID" id="87858375"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="368" mass="42684" checksum="A9884A9FF8C5BB84" modified="2024-05-29" version="1">MTTATEPEAGPSTLAPVSEHLQEPFQQHIIPVENFNDGPMFEVDNIDEKSDPGFEDGDYRSVTVSLNRTIREYRHINGRSYHNYDGAYYWAPNDDTQNDHLDMVHHMMCLAYDNQLFLAPLKNPQRVLDVGCGTGIWCLDFAEQFPGAQVIGTDISPIQPRWVSPNCKFEIDNCELEWTFAENEFDYIHISSLIGSIQDWPKLYKEILRALKPGGWFEQREFALPVRANEGALPEDCVYDEWARILYETGYLTGCTWRVTEHWKEWLREAGFTEKIHTHQVKIPIGGWPKDKIQKEIGLFNRLSIETGLEGAAIYICKMVLGWHDVEIQLFLERMRAVVKNPKIHAYFPLKSVWTQKPFTWVERQLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHY3</accession>
    <name>A0AAE0JHY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_157648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682931.1">
        <property type="nucleotide sequence ID" value="XM_062821181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHY3"/>
    <dbReference type="GeneID" id="87858335"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF67">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3347849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="495" mass="54663" checksum="54FAD44E47EED66A" modified="2024-05-29" version="1">MTSNNHASNADKMGERPSTEKMERTVSDSEHHRNMTRRILWKIDTRVLPVLVLLFLCSFLDRANVGNARIIGLEKDLGLSNTQYTQGLAVFYATYIAIELPSNLVLKKVTPKIWLPLLTIIWGIITMCLGFVKNFGSFFGVRALLGIAEGGLFPGIVLYLSGLYTRQEMALRMGIFYTAASLSGAFGGLLARGLSAIGPRGGLEGWRWIFIIEGLITILVGMVTYLLLPTSIVTAPYLTEEKKEYAARRLQGDTGADTADRFNPVSEREEKFKWSEVRRGVFNLQVWLTGSAYFALGAGLYSFGLFLPTILNDLKITSNPNQTQLWSVIPYAVATPVTVLIAFASDRLKLRGVMMLFTLPIAIIGYAVIANVASAQVRFAMTCLMAIGMYSSIPCILVWNSNNSAGHYKRATSSALQLAIGNAGGFVATFVYPPKDRPLYHKGQTILLGLLVYAWFAILANVLWCNKINKDKAAGKYERYEGSGDDRDPAFKMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI44</accession>
    <name>A0AAE0JI44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gpi1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_492180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683379.1">
        <property type="nucleotide sequence ID" value="XM_062827748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI44"/>
    <dbReference type="GeneID" id="87864902"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="793" mass="90420" checksum="624B87EACC3C8570" modified="2024-05-29" version="1">MHPFSVLTLGIFVAGYITARWDLVTRLYELAIFAWNYGVVTRAAKGFGVLSLVFLVVFIPVQRLATLESNLHPRSPGSEDDGLMRVFWPTDLPRSDCKGVVVGWRNSALDVLVVAVLEEVEPRRVESALKLGNLLRNAPHPVSRIYEQCGKSSISVLGVSNTPDTVEVDSSWIRVTITPKQRVPSVTCARASSIQIILFERPLPGRMQYMSLNPIALALGDKHDGFRQDFADSGEEDDEKRERLNKETKRKLVEKLKQHSVVKRIPSPKERALATIVNQINWAWELEKLLQQNVSRIGTRPKRALSVSERVVESATTARDMILVWLWDMITIYVLPVIKKFFVLGLMAHRVVAEMLLRILEWRLRPRYAALKDISATAQQVEIRLQQFCYWPMQYVTLRLRKNDWASVTTSHPDYIRFYNSLWLVANDVIIGMAFGSYIIDNAGWVADEISRLLTTYTVEALQSSISWLMGWPAGLKLNTELAAFLGDLFLWVIEYWASCIETIRPMLPRIVWIIGFSSFAGASMPLALFSDLLSILTIHIYSFYLASARIFHWQLNILQSLFHLFRGKKHNVLRNRIDSCDYGLDQLLVGTILFTVLFFLLPTVVVFYLNFAIARMAIILFKACFDTALSCLNHFPLFALMLRVKDPKRLPGGIRFELRDTQDFGATCNNNNPLRQHPSTSVISLQPIPLDFKSMFYQYFQMGNRIRKHYLSPRVALCLLTGKFVPPLNRKNLYSLQYSMLPAKRAGVMEMWDAVNSLPASKRKSMPVQVPILANGRRFPSNYGGGRSRSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI81</accession>
    <name>A0AAE0JI81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_538732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683218.1">
        <property type="nucleotide sequence ID" value="XM_062829097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI81"/>
    <dbReference type="GeneID" id="87866251"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3348136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="515" mass="58542" checksum="94E0A0394191BA5D" modified="2024-05-29" version="1">MVLSLDSSKALVTGAVVVVLYLFTTRLIRYKRLSHIPGPPTTGWSSFWLVWRQAGDNIPEHFGKAIGKYGPVVRIAPNWIICSDPDEIRRIWSVRAGWRRSTWYHSFRFDPHRDNILTYPENEDHRRARTLLISAYSARGFETQERLMDEHIVRFIDLLERKYVSDNKTSGGRYRPLDMSHVFPFLAQDVMTAVEFSKPMGLIEQDRDFLGVLGIFEKLAKVMVVTATLTWVHDLQRAPILKPFLPKAGDGTALGRLLQLIRDHTDERYRDGPDKVWKDDMLQKMVEAGLTQEEADAEALVALFGGTDSTAVALRQTVFYLASTAPAYRALQEEIDGEILRGRVARPIITDAEAKKLPFLQACLKEGTRMWAPIGGLLAKVSDKDDVICGKHIPAGTNVAWASKAVLRNREAFGEDADVFNPQRWIDAAGDLADAERLRRMENTQGLVFGSGTRWECLGKRLAYVELGKVIFELFARFDFTMVNPENPMKTSHQSLVFHKDMFVKITKRENPIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIJ5</accession>
    <name>A0AAE0JIJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_523499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683589.1">
        <property type="nucleotide sequence ID" value="XM_062828798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIJ5"/>
    <dbReference type="GeneID" id="87865952"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="20"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3348507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="626" mass="68417" checksum="3F5DB58CC9AA5158" modified="2024-05-29" version="1">MALFQRPPDEKGSVWFSVLIGVFVAFTGLLFGYDTGTINGVIAMKYWQQNFSTGYTDVKGELTISPSQQSLIVSILSAGTFVGALASPLLADKIGRRWSLIISSWVFNLGVLMQVISVAIPLFVAGRFFAGLGVGLLSALVPLYQSETAPKWIRGLIVGAYQLAITIGILLAAIVNNGTHKRDDTGSYRIPIALQWLFSVILIIGMHFLPETPRYCIKRGDMTGATRSLAKIRRLLPNNSAIIEEIEEIRANYLYEMSLGNSSYLGCFRKGMLKRMLTGMVLQILQQLTGVNFIFYYGTQFFENSGIKNPFIISVTLATVNFLSTIPAVLVFDKYGRRPLLLWGGVAMCICHFMVATLGTTTTGQTASGVITVLNSGGQKASIAFVCMFIASFAATWGPLAWVVTSELYPLKHRSQMLSISTATNWLFNWAIAYSTPYLVNYGPGNANLQSKIFFIWGTACLLCVAFVYFYIFETKGLSLEEVDEMYQTPGLKAKNSSKWRPSIHFRETPLTEVTYNKTTAGSPAEPETAPVAKTTERTEGEAVARTTAPMAGSPPQTDSVPKTLQTAILQRPDDAVAHHHSPLPRPTSLSKLPSPALHSLKSVPSLPTYTDEGTTSSRGPRSIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIY7</accession>
    <name>A0AAE0JIY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="7" type="ORF">B0H65DRAFT_165872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIY7"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3348100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="273" mass="30536" checksum="FC8D0150ADFB8FD7" modified="2024-05-29" version="1">MACIIDKFSDDESDLELSSSTLDALKSFYADRDARAEQFAKLQAEAEERHALNVKLSMDAFTEDWNESQFWYSDETATFLAKQLLSGATPTTSIAVVSAPSVFVQLKNLLNSDAYADKPKPKLTLLEHDNRFAVFADEFVFYDFAQPLKLPATLKGAFDRVIVDPPFLSEDCQTKAALTVRWMFKPSSGPEKIIACTGERMEKLVTEKLYKSYGVRTTTFEPKHARGLSNEFYCYANFEVKPEEGAGAETPEGKGWTLRELGWKEKEGAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJC9</accession>
    <name>A0AAE0JJC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_89561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683783.1">
        <property type="nucleotide sequence ID" value="XM_062831533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJC9"/>
    <dbReference type="GeneID" id="87868687"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3350488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="569" mass="61093" checksum="45863AD242A52396" modified="2024-05-29" version="1">MGTDRKGPKPLASPDLDAASINSVAASEILDVNGLPISGDSLEYAVPESRKIGVTGAVFLILNKMIGTGIFSTPSSIFASTGSVGICLLMWGVAGLLTLSGLGVYLEFGLAIPKSGGEKNYLERVYRQPAYLVTSVFAVQIVLLGFSAGNSLAFGRYVLLALGYDLPDGWPARAIAVLCISFVVFLHSVFPKWGLRLTNALGVFKVLVLLLIVFSGFAALAGHRRVPDPHNFDDIWSIEKGDGFGGGGAYAYATALLQVVYSYKGWENANYVMGELKHPKRTLSIAAPLAVVGVTILYVLANVAYFAAIPKAELAKSEVIVAGLFFRNMFGESAAAKSLPALVALSNIGNVLAVSFAHSRVNQELAKEGVLPGSKFWASTKPFGTRAASLLLHWIVTVIVLVGPPPGPAYNFLVNLYTYPNAWINGLVAGGLIYLRLSKTEGWSSPWRTWLPVVFIYLCLNIFLAITPFIPPNDDWNADGYPYYAFPLVGTGVLGLGAVYWVVWTKVLPRFGGYELVAEKIIDETGAEVVRYRKISARNAPSAERESLLRRRPVAGASADHGSYGTTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJP1</accession>
    <name>A0AAE0JJP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_420209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAK3350897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062829448.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JKN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_419458</name>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684398.1">
        <property type="nucleotide sequence ID" value="XM_062824210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKN0"/>
    <dbReference type="GeneID" id="87861364"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="162" mass="18198" checksum="AB486AE1DFA4BA2D" modified="2024-05-29" version="1">MNDPFQSDNDTNSPPFPSPRQGWEEDPIATYYLRALNREIRALKSDYDLACSCHTYIKMAVLSLRLYLHEWEGLMGEVMGCSDSETEGKLVGSEGVGYEGLKGLDGYREVLELMDMRTYFTFPIYLLPYLQDLPQLLPSASLSSRDNAAFDVSWLSSGEGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_134796</name>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Ascomycota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685080.1">
        <property type="nucleotide sequence ID" value="XM_062820851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL80"/>
    <dbReference type="GeneID" id="87858005"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="343" mass="36237" checksum="6D858F97F38EBF85" modified="2024-05-29" version="1">MKPSTLLTLTATAASTTSAFTLPFKFRRDTVSTDASNNPNRRLLHSPPTNTVGIAGGHIKATSGINNRPPSLRAGAYLPYHPPASTPDQPTQNQDMIQSVTGTVVIPSINMPVSGPTAGNSAGEYSASIWVGIDGASATDNFITSIPNCNPLSQSLRAGVDIFWDGTLGGQQTPYVWTQWYPAEHAKGFLDFKASPGDELRFTVSTGPHGNSGGSVMVENFGPPQSPKGVDGKVKIPIATGSLIWKDMPGLCSAQGSWIIEDFPLQERPELPSALGNFTDVRFGEMGVATWLGGNFTGEEVLGKDKLKMLEIYDQGQGGTLAKCKTEGGGEKGGVVCRRVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLQ6</accession>
    <name>A0AAE0JLQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_556350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684856.1">
        <property type="nucleotide sequence ID" value="XM_062830050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLQ6"/>
    <dbReference type="GeneID" id="87867204"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="66165" checksum="038DB4342E0B684D" modified="2024-05-29" version="1">MNFCYAQINKPLHQARDQEGPNAVEVMFPLSGVFLSPEEVHPPRFAPASLPFRGLRPRIRPGPKKGFGSTSEGHAHYIWARTSPALICRGPPAVRYSDRRGMPLVAHDIGTQNQSHVSRQQRGNTQQTENRTHRATTAQKRQQDTDFSYHFVKITASTGIRRHQCHTASHSLADIEIHAARSSQRLWGREEARDKVPAPTLRMADRRPSEAVPTTSGRQSHAIPAASFPTHNSPRTWLITSALTPLAVRLIRQLLAHGDYIVACLPPHEIEHEDRSAEFRELINECKSNRKDREGWKDRIRPIRCDSRVMGQCGAAVAEAVQIFGRIDIMLCCRAEAVVGTVEELSTSPATQNLVRDQFETVYFSQVNFIKAALPQLRAQHTGHIMVLTSIGGHIGTPGMSFYTAAVWALEGFCDSLAYEIAPFNIKMTIVQPNKEILSLTNRLIFSPPLPQYEADLNPAPNMRDVLSTVLNSNPDTYIEQSEDEIQYRYAKLPPATLDKLVMETVHALTAIGGHENPPARHIVGFEGAIAVREKLKTVTEELEDFVEVSLAVDIFDSELKAEARKGRSEMEATQGMGAGEGSSGAGMGGFPGMGPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMK3</accession>
    <name>A0AAE0JMK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Defective in methylation-7 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_520367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685027.1">
        <property type="nucleotide sequence ID" value="XM_062828731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMK3"/>
    <dbReference type="GeneID" id="87865885"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="74730" checksum="D7429826F7D71456" modified="2024-05-29" version="1">MAGPGRPRRRRGSSASIDSTDDRRRRWTRELAILKPVTPGTSDDLWPYFAVLTDATIYQKDGKTLANPLHVDLEGPFIVRGKLEPVEDDDDETREYFHKPYNKATYIEISRSERYSIGFDPNTLWVSGASGWFEIIPSRKYEAMYSQVMEAITLYYGIMGPYEEFKRLLKKADKKKRKDRKPPPLDEIFFTYALAAGDGGVTVKEEVEARCHKWAQFLLAHFPKESEIKWQDTEFAAWLQAAHPDLQKRISDVAAGLLTKPAAEPEGLLARDDYSPQSQSLAIREPPKGRTTKTSRQASELSDQRSDKGKGIARDSPLGTPAPAPVSTRHLPSNSPHPRASPAVITGSDDLPDDPVDRLIILLGEVAQRVDIKKGKMSQINANLFYNCRIKYYTAARELCEHFAKDLLERLPPMWDNTPYKAWLEDVVENGRPAPTELTVEDIPQYLNRRNRRQTHASRLSSALGASPSVEAESKDEVRAGKQPRVGRPSGKVATLRVAGSKRLASDMADEDDMPPRRGRKALKRTVEAAEDEDSDANSVIIDVADDTGVIPKDAVRIVVQAERLPTMSPAGPNGTWTCDQEGCSYVVRSADEPAGQELISKHFKDHEEQAQKINLAMEESRAGHLPIKYYSHLLDKIQAMGKNALAKKRGSLNGEPLPLPIKRRLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN17</accession>
    <name>A0AAE0JN17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome C oxidase copper chaperone-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_543662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685708.1">
        <property type="nucleotide sequence ID" value="XM_062829242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN17"/>
    <dbReference type="GeneID" id="87866396"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="77" mass="8204" checksum="FB0E02247A161B91" modified="2024-05-29" version="1">MGSQASSLTALPSAVPAQITTPSTDAPAKPKPCCVCKEEKAKRDDCMLFSKSDDPQKDCVSTIDQYRACMAGFGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNK5</accession>
    <name>A0AAE0JNK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_413672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685943.1">
        <property type="nucleotide sequence ID" value="XM_062823858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNK5"/>
    <dbReference type="GeneID" id="87861012"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="92133" checksum="1ECB2F90234E4932" modified="2024-05-29" version="1">MTGRGRGRPGTRQQQPAEGTTVAVRRATRLQQQSPPPPQGEQAEQQQLQQQQQQVQDAQIDPAITGTQESEMPPPPVPAPKGQSKDSEQAFVEVARRSTRRDARAGSMVSVNSVLTRVSGTDAFSSQPETPSLALRRGTSTSLTGAPPRGVSIHTASELGRTPEKRGKERLLMSRMLPLLFASADKLFAFLSTIDAQQRDPDEQAALEEEFEMYRLRYISNNSEPSINLKHVLSTMEVDPNSPAGSDACKTVTLANLATMFDRIDAIQQGNAEDDLADLQVCDDIIAQSLVVDGVENSAVLKPEDIMTQVVEIRTLLFMLTLQNFEAQNQLPVSRSEILADTFCQEIPSVEAVEDFKQGNKDALPLKSVPGIDPNGDPWHKEEYITRLRSICEYLPNESIDDTALHACLEQLRELYDPHRSLRVIRDSLEACFQEIKRQLQPVPPGPSYPVTQYGAPDPSAVESQIQSQLESEALADTGQRQLDYMATLRTMKIDREAESDASQPQDGSFSTTQDTLGRGHELQSSSYPPIGRAPYPPSFDAQQSPPLAYPGHPGAFQNGTIYAQSAAQLGRPKRASPGDNDGVVDGADAGKPPAKKPRTRRKKPTVPIPAAEGAMGDVGTPSSSAATAAAAVAAVARYPPFTDTQVELDLENLSQRTRELSAANRKAREPQSRSPWVRDDIKTLVRAVDAYKCKWSVIEKDIKSGKIHFVRPRDQQALRDKARLLKQDFLKVDAILPRSFDLVVLGQKEKNAVIACGKNPDRKEADVRNGIPINTEYQKPMQEQADAAEAEDQAQVQGEEQPEMQLEAQAEVQTEAQPEVSAMVPAEVPVDAEAIEAASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNL0</accession>
    <name>A0AAE0JNL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_25604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686185.1">
        <property type="nucleotide sequence ID" value="XM_062822554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNL0"/>
    <dbReference type="GeneID" id="87859708"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="688" mass="77636" checksum="B1EE3163F6078237" modified="2024-05-29" version="1">MEQQEQQQGKTRLMEDETEVTNFETTPVTNSWFSRSWSLYAISLVTSLCFLAALVGLLAAFDKKTVDDKQQFTLNTAIAVLSAATKATLLYSISDAIGQWNWIVFSGPRRRRLLDFDRIASASRGPLGSLILLVDKNVKRISIVRMGALLTLLSVAMDPFAQQLLKYRQVPRYREDLDGEGASVSRAMKYSRGSKYVLRETDSDGGALVDAEADLTMQSAIMYGIAEPLESVLQQTKFRCPNGECPFKGDFATLAVCSSCMNLTDQLLIKKVDPDKQLNISLSHSKGARSVVTRRGDPIVQYSLPNDQYLDNSIAMTMKGTANPAEVITQDRLDWQQKAKTLIWSQSIIRHRTDPVQLLPDQESNQVEAIECALYYCVKQITTANVTSGRYFEESIEDTPFVRDPESWTFDLDGDNLQGLSNLTAAQNDSIAFHPRLSRFPRTDLSLRLNLDNHHNVYNINQVAVDGISAFMQRTFSTCVSPLTNCSDSAAGMGSKDFEAAAVSLSDNWKPINGYYDLRSNWFSPSIARVFWETDDLKQKWASIAQGLTNVIRRGADNLTDAFEYGADNPVFGGINEVRSVEYLEPVYHIDWWWIILHCALELVGILFIVLTALRSTSWSWKLGWWGARLSGGGGAAQGEVLMSRRKEPLPLWGTKWLRFWPTARRLRVFWMVLRQCRRWRLEGGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNY3</accession>
    <name>A0AAE0JNY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_438344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686442.1">
        <property type="nucleotide sequence ID" value="XM_062825366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNY3"/>
    <dbReference type="GeneID" id="87862520"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="43"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1014"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3355064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1218" mass="136524" checksum="0D5538DF1B2C8B07" modified="2024-05-29" version="1">MSGSSAMTNGGGASFMDVDSQPPGGSKFTDLPDEIQHITADIMPLSLLLTRLSQWTHTKLQDEIAYLASKPLPQAVLNGNTNHQSADNHDTSQESLEKKVHLLNFLQDMHSKWVKTLVITEWSKKAAQVGALIDIRAHYQELFWELIRMKQDLHWAKVPGPDLKTALEVLTTGQASWMPELGYIEPPPITWEEKEAFIDNINTMLSVRLTFDEHEKIPAAFRDYNISNGRVTFKVKGEFEVDLTIGDEDFEQQFWFIDFRFLFTPAPAELSHGVRTFLENKVNTILGDQGLAGCYNYLHEFVLTQKIVEFRRQATELAMGRWVDTLKVEKLNRAMSIQYWLKPPHGLEGPSSQTAKSWVLLGVWSGKGVEGDLDSKPSSYISLRWFRDNKEVKDFDIPLNVETISAEKLLTAVIASHVEYILTSISSKLLSKPRFAQKHARLDLEISKEEPQNSSLAVQLFDNDKAVIKIEPLTGFFTLFPRSPVFLKGQMKLNTSSNAAEEGANLMEQLRFDHTVKDLNSRVRSIGWFVCRPPITQEETKAIVYSDASGSREAFKAVWLRKANWMTRQWFVMMSMSLGGDQWWLVDLSPPKPNFPAGRLRLFTKMPMTSNQLTLSDTFFRNLSVYAAGMISHITDLRKLHTLKKSHTALELPNHSLPPQVRLPTIYVRLSEMLQQRPGSSSRTLTWAKGFVPIIFKGVRTHTGDQEGPADATAAQVRRDTPAKIRAEARLTVIDRNKFKSLRGNVDHDVVYNHRTGQFSLKLRADMGTPVVDLLADRVQALERLMEFVEAIRLAGSNAIPQSVALREVVFTYSNDPAEPVSGPSQGPRAWSVHLDLPKDAKVILTLEKGNPHMRALDMLQEMAQSTKTELLPSYLPFSLPLYRVLDRIEDEWESIAAKNAGNVAIVVKAAEWVTIRFSLSAPTTRRLLCLDIRTMGRKGRLLWHVKRTDEKGHERPLNAPQDEFDTSLQRSVWHAHGDGRKSFGTSAAADPKIGIETLLWSISESVKSLVGTLPPPPITAPHQGGAVQDLKQGHQQTPQELVAAQAAQGMPPQRPKQQPPPPSQPQQQHRPVNQPQAQPQPQAQPHTQVQLQQAQVAQLQAQRQAQARANNNRFVNRAHPGQPPQQRQPGPQTQAQQQQQQQQRYQIQQQAQAMQRMQQQQQQQAAQQHAQQQGQAQQGQRPVHGQGGPQGVPQGQPGQGGAGGGMGGKNAPVVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPX1</accession>
    <name>A0AAE0JPX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_485079</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686693.1">
        <property type="nucleotide sequence ID" value="XM_062827678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPX1"/>
    <dbReference type="GeneID" id="87864832"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042241299" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="22"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="21"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="740"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3355315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="972" mass="105606" checksum="0E56E58FE6DDD60D" modified="2024-05-29" version="1">MHLPTQLSALLLVALPSVVRAVFQDEVGHIDYHYELLGLPQRETTFFHKPRRDDKASLLYTLSDVGVLGAVNPSSGAILWRQLLNGTITDGGGFLRAGEGQNWLASAYGQSVHAWDAVNGRNKFWMDFAGEVKDLEIMEMTENNRKDILALFDENESTVLRRLSGNDGRVVWEFKETSGDVPLQVSTNVEKVFVISLRGSAGAYNIKVTVLDALSGKREDELVIGTKADVHDKDDVILVGANSAAPIIAWTDDVRQKLRVSVLGQKTRQEFPLPADTVSVEIHAPHLVQPQPHFLVHSKTSTGHTAEVYHVDLRTNVITKAYQLPFTSGPGAFSTSSNGANVYFTRITDKELVIFSSASDTVLGRWPLKTSETRLVAIHGVSEVVKKAGTDSYAVRSAAVTDTDEWILIRNGDVAWSRPEGLTGAVAATFVEIPESENLAKTLEQEAHSNPLEAYIHRVKRHLEDLQYLPAYLNNIPARLMSSVLGTEVSTHDGKLARDSFGFNKLVVLATRRGMIYVLDAGNHGKILASKRVFDLPKGQKWAAAGIKADDSTGIVTILGTNNDETIVKILPGTSFNMEVFSKGPEGSPATQSAALLNTVSGPRLFPVGLDGELQGLTSDVLPNQVAVVRGSDRELKGIAIADGKQTVSWTFLLPKSQRIVDVATRPSHDAVASIGRVLGDRTVKYKYLNPNTLVVAAVDESTKVPSLVIYLLDTVSGQILASSKYEGVDPKKHIECAMAENWFTCTYFGQYRLRDGAQSLKGYQIVVSDLYETDKPNDRGVLGDAENFSSLGPIDAPGDVPLPSVVSQTFILSAPISALEVTQTRQGITSRQVLAYLPETHGIAGIPRMVLEPRRPVGRDPTAAEAEEGLIKYHPAIEIDPKSVHTHQRDVIGVQKIIAAPAVVESTSLVFAYGIDVFGSRVAPSFLFDILGKGFNKVTLIGTVLAITAGVMVLSPMVRKKQINALWGAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ05</accession>
    <name>A0AAE0JQ05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_438606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686738.1">
        <property type="nucleotide sequence ID" value="XM_062825379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ05"/>
    <dbReference type="GeneID" id="87862533"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="287" mass="33161" checksum="83BEDAEBC5D609B1" modified="2024-05-29" version="1">MPDEKAIDTCAEGNLKWTRKKMSKSEFHRADERRFLDERGSSGPLAPNGLNPATIMEKAVRERIIDSYFYKEQCFGVNEADIVDRVVEHVDFIGGVYGTVQKPSPFLCLAFKLLQLAPSDDILNEYLQFGGEKFKYLRALALFYIRLTRKDQDVYKTLEPFLEDRRKLRRKGRNGTSLTYVDVFVDDLLTKDRVCATSLWKMRKRDILEDLDILEPRVSPLGNIEDLLEEEDEEMRKAEEEQNNNGSESEGEVQVEVEILFPVPITGQEEKLTDEIEIEIKDTGRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ85</accession>
    <name>A0AAE0JQ85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_33508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686422.1">
        <property type="nucleotide sequence ID" value="XM_062823554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ85"/>
    <dbReference type="GeneID" id="87860708"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000010">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA soluble domain-like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="108"/>
            <end position="120"/>
        </location>
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            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355044.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="93241" checksum="5121FDD2D5254AE2" modified="2024-05-29" version="1">MDQNIPPRHDASESNSGPSAGQPPQNQPSRRRKNHRAGKKKKNRRKSFGVTSEDMAQESMNDEVLAEARNGFYSRPGNNFSNTSIDSEALLDHREQQPFIRPRRPSMLVTQSSHLTTPQVASRLKTVVASSNNSEDEHEGAPLLSSSVFQRSEGYTGYGSNDTARRASAASRRESSRDSSKKRRVTSLGATGTEGYNVNYPPSVPGSPLMRATDRDMSMSFGDIMLREESDSMPHSPGRRTLNEESNLGGSMERRHTIALQAEEDVCFPQDGLSEIADEDLRTRDPTAYRMKRRRRSKWPDLAILEEWSRYEKEGRSEEGRAKKITEPQLINGRLRPVHRGWYRAQEDAPYRFTYFNEEFQSTIHSQTISELVQPGLSFKQLFIPDPRVLSDSSDDEDDEEDQRHVALDEVLGGQNGDPRIPSRQPSLATTTQGFFDARRDRGSNAGTTLTESKRTSGEHTPTDAKSPERYKSPPTEKTSKPPKYGDRPVWWLDIYSPTEQEMKVISKAFGIHPLTAEDIMMQEAREKVELFRQYYFVNYRSFDQDSTSDNFLEPVNMYVVVFREGVLSFHFSQTPHPANVRRRIRQLRDYLILSSDWISYAIIDDITDVFGPLIHNIEDEVDDIDAAILLLHSEDDPNFPTDNLREKSEAGDATSAEAGRDMLRRVGDCRKKVMSLYRLLGNKADVIKSFAKRCNEHWEVAPRSEIGLYLGDIQDHIVTMTSNLSHYEKILARSHANYLAQINIRMNERQEQTADVLGRLTVLGTIVLPMNIVTGLWGMNVWVPGQGIENDLKWFTAITAGLLLFGFGCYLIAKRVYKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQJ8</accession>
    <name>A0AAE0JQJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_61426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062831163.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="305" mass="34354" checksum="82C91FB47270AC87" modified="2024-05-29" version="1">MLVRRLGARATPKSSTRTAPRPPRQPPTLRKLYNSNRPAHIRNPIVRDGLTLRAYGVIAVYLRTTGSLDTYFKELKDIQDQFAQKLQPQFRPSLQLIQNGRGLEADVAGAGSRSDAKRHKTSARGDLHTTVDGMAANFNAQILAMREELDKLGSVREDLDRLTETMGDTLNRLTGVEAENRELKKQNYELKEYAVYFFKKNHDCGLTLRRPLPRHSTTISSVDASGPLPKEAVLLLQRTEAGGERFCRFAENNGELCDYQGPFKDRDAMRRHYKDSHRIVLGISLAMRSTISPAALIKSEVRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRB3</accession>
    <name>A0AAE0JRB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_565212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687447.1">
        <property type="nucleotide sequence ID" value="XM_062830275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRB3"/>
    <dbReference type="GeneID" id="87867429"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="788" mass="87861" checksum="B56DB77209BFD2DE" modified="2024-05-29" version="1" fragment="single">MASSIQSSALARIIDKTTNIVDTLFNNNMDDARPASDNNTGLSDSADIDTTFNVVIAMILISTVTGNTILAALSAIFLIVVLRITTPESLDTPTNVDATLTSTPSQDAHNDNEPSSLIVPADEKVRIYHHIRPTVDITEVVAPTTTTNGGTTATTNNDDDSFGAIASDKFDHKTFEKHLKEDKMYLVHLPIPNPSITTTELKAAPIVQTTKIVEAARPDPKNVNIPIVDGKLSTIYEEDEEEDVELPRSCDEADKADSSFNDLEDFSDTEENIIAFVKKVHRLCDELDKVERFSDPVEHTIALARDIEATFQQWDEEDLETFSDSEEDAIALAKHIEATTRPSPPESPARAASPARTPEGPAARFTASGFLIETPDNSPDPRTPIRPPACTPEAAPPQTPIGPRALKPIFASPVGESFSHTRKVSNETNTSDETDNSKTTATAPDSPATQYSSPDNVYEYQAMTGFTVCLSAKKSTRIEFDPIAQPGDDIHYDRRLLKEETPSPSPARCRSQSSNQFTSSNGSEDMSTPYDFTNYRGELEMLAILERPEGGRYAKMSCGNWYWLNDDGTLDELSWPEYRELIAFIVGDVASLPAKLHQTALHEAAKLQNEKEPIATNKEEELPLPWVPWDSAGEPETVLEVNHEEELPLPWVPWDEPEVVNPELEPMPEDQTDENTNTSITKDITEINTTNVAAEVAEDIINSDQPDEKWWKAEEMPPNWFVIEHIPCPGENYHFAEYVRGSDDMWYFRLAGPEYRPLDARELRWFLSWRHDARPINTIVELEEDEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRH0</accession>
    <name>A0AAE0JRH0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_54184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687022.1">
        <property type="nucleotide sequence ID" value="XM_062829188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRH0"/>
    <dbReference type="GeneID" id="87866342"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="51256" checksum="8BE834CD2A998E3C" modified="2024-05-29" version="1">MCFGSKDKTDDTPGPRPAQPQQSPSQAPGKVNMPSPAQYNDQNDYAPPSGPPPNFGHNQQHSGNDYAPPSGPPPSWGHNQSSANDDFAPPPGPPPTHARPYQNNDDFAPPPGPPPSHHQQRHDDFAPPPGPPPSHHQHHQDDYAAPPPGPPPSHQQHHDDYTQAPPGPPSSQSKPPANKQHDWESFVPDTALFPPPPAFFTGYDRSHTTNATEEEANAGEAWCAANPLTAPMDLDPVALDALRTHNIRLMSSPQFRGKLDWVSAGVWKCKTEKAAGDACIISYPPLYCVKYDSPLIPSHTSRTTKTIYYEVSIPRPASNNPFLGAMGGGSGGGNDEITLALGFTALPYPAFRMPGWHRGSLAVHGDDGHKYVNDRWGGKDFTRPFRRGETYGIGMTFTNTGGKLDVNVFFTREGRITEQWDLHEEGDAEQDLPVTGLEGFHDLSCAIGTFSAVEFEAVLEPGRWKFRPQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJC8</accession>
    <name>A0AAE0MJC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYB DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_512888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676506.1">
        <property type="nucleotide sequence ID" value="XM_062828616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJC8"/>
    <dbReference type="GeneID" id="87865770"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="296"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="296"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44866" checksum="1DAB3266968CC03A" modified="2024-05-29" version="1">MKKQQQQQQQQRVPNDVHAQAWRQPTPSMPALPQHHLPPHQQQQLQPQQQQQSAFANQSAWYPSPNHYAQQPELTRRDQPPMDFRAYAQSQQQPPQQQHAQHQQHHQQHQPQHQQHTQHQQHHQAAPVQPPMSHAPQPQVTPQQPAQQQQQQQQPTPVPAPAQPRGRKRNAPGAQPSPHPQHAPQIAHAPPHAPQHQAQHAPSQHHVSQAGQPQHAPVPQPPQQQQAQQQQQQPQVQAHQAAQAAPPAQQTPVPPPAAQPVPVPQAQAPAPAPAQAQPAAPAPAPASDASAPPPAKKSRTNTPWTPAEEHRLKQMRDAGNSWAEIAKTFPTRTEGSVKKHWYKDMHYAEFAEDESAALMNAIKEYENNKWKAIGAKVGKPAKACEQYAKEHFPELFAPQKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJK9</accession>
    <name>A0AAE0MJK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_76818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Barry K."/>
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                <person name="Labutti K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Kuo A."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cros-Aarteil S."/>
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                <person name="Labutti K."/>
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                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <strain evidence="2">CBS 560.94</strain>
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    <reference evidence="2" key="2">
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                <person name="Steindorff A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677837.1">
        <property type="nucleotide sequence ID" value="XM_062827500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMU2"/>
    <dbReference type="GeneID" id="87864654"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="201" mass="22814" checksum="751C845BC7261C59" modified="2024-05-29" version="1">MGPVEFPRSLVHYPSGRAAFHLIFRATLSIHLASGICHPIIPSRLDVMWVSCACPQKSIRKKIVGMRALFEWVWAWWRKETRERWAVGGGRWTRKRVVCGWTGSMENSLHFFFVDPPVCLGSAHVRSSAVGVGRRRSPSFPRCAHRPSRAERSKKKKVPLHHHSLPREPLFKPLLYSCCSSGRAARSCSVPRSRMDGWCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMW3</accession>
    <name>A0AAE0MMW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Monocarboxylate transporter 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_319979</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677808.1">
        <property type="nucleotide sequence ID" value="XM_062823400.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860554"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="9">
        <location>
            <begin position="736"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1297" mass="142853" checksum="267B4C7E991DFB56" modified="2024-05-29" version="1">MPTIYEMEAFINWDGVDPAAMPGARHPNDLDLALENVDDDDFASWALQHYEHSNSLGIGETATANPGLILHSGDPIVAFEDSFEMPSSPCNHCQANGYQCKRIREGSYNGYCTGCVALNRVCSFGLVDQPTLPRNPGSTTSIEEQETAAPVAPATKVNGRFSRESIKILKNWLSTHHKHPYPNDEEKEMLQKQTGLNKTQITGWLANARRRRGKAMGAPRSISPGVRSLSNNVDIPQRRPQLELMNPLQRWQVSPPEHEPASVTAIARAVTASATTLSSGSPHSNNFNFTDDGSNRSLCAASSASSFNTSISSSAYSYGTHDSLGSYGSSMNRGRRRRRRKAAPVPSEKRNSLSAPLKTFQCTFCTETFRTKHDWQRHEKSLHLSLERWVCALEGPRASNPENGQVSCVFCGEANPDEGHIENHNYSICQEKTKEERTFYRKDHLRQHLKLVHGVKFVDWSMEQWKATTPEIWSRCGFCGIVMDTWSIRVDHLAEHFKAGQTMADWKGDWGFDTPILEVVENAIPPYLIHDDRNSPCPYTATQAPPETARNAYELIKSELMYYLTNERDIRGRVPTDEEIHVEACRIIYAAEVQSNQSISAIPSWLRDLLLSSEPLALQARMAPIRSANESRQAVLRINGKGNIFEDDPMEHELHEYVRARRLLGLTAMDSELQYEACNIIGRMEESSSHPSEGIANFLLRLIHGSTSWLAEFRQRAVLPRSEDVGDEARRSTDPSKVDSTIYNYSRLERELAEFLHMQRSMGVEPADVDLQNKARIIIYECDDSWNQTAADNSEWLAAFKQRHVSPEASAVALATYEPLTISSVSRYRFTPSMDMATWMGSSCFGGPQNTSLGSIGAPAFDTAAGVDGHIGKTNNAVKIGPYFFNDANCYRRLARELGAYVASVMSPNSPDCHIPNDKELQLQARWILYQDDDPWNQTAADNAEWLRRFKRDVGILTDSSLPGLPECTQWSATQGGSGFEPPYLFPNPNAQVTTVEMDIPIKMKEAKRTFVAERETANKYVRGFRTRWQRPAVVFCSRELEKGLVEFVTSCVMGTSDGSGGGGGGARGMFPSDEAIRAKAREIQKMSTTSADDVVLLEKFKNMMRERLGLVSAFTSLGSTPGFSEVGGSMGLMQSSSVDTSAVPSPVTAAGFTTRTTTSPDMGMSMDFSMDLGLNLGDMSSSMSNIGAMGMANLTDWSSTGLSMGMGTSMAGSCTGMGMTLDMTNTNMSTSMPTTHMGLLGAAGGAASAGGGGGQDDHNMIMMFTENEMDDLLQESSFGFSSNDDDLAVMGGIGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN19</accession>
    <name>A0AAE0MN19_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_313353</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677601.1">
        <property type="nucleotide sequence ID" value="XM_062823328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN19"/>
    <dbReference type="GeneID" id="87860482"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000116">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000018">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="17" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3338150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="445" mass="47813" checksum="C310810644688569" modified="2024-05-29" version="1">MALAVSAPGKVLLAGGYLVLDRNYTGLVFGLSARINVISKDIQASPGVHINEIIVKSPQFLKAEWRYGYHLADEDGGIKTIQLQGGAAASAKGNPFVETTLNYALTYITRRAAYGTTQTLKPVTLTILADNDYYSSPSTGKTSSGSRFAGYSTTLEDAHKTGLGSSAALVTALTASLLSHYLDPSLFDLATNEGKRILHNLAQAAHCAAQGKVGSGFDVAAAVYGSSHYRRFSPSILSSLPEAGKPGFSAKLFSVVNGKDTESQWDTEVVKDAVSLPKGVAVRMCDVDCGSQTVGMVKQVLAWRAAQPQAAKELWDELQRRNEKLASVLKEGKTEEIRPAVHGIRELVRKMGTESGVPIEPDSQKELLDALEEGVEGVYGGVVPGAGGYDALALLVRDDEETTKRLEEFLRGWSERKGGKVRLMEVSGEMEGARKENLLKYQGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MN34</accession>
    <name>A0AAE0MN34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_552674</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677646.1">
        <property type="nucleotide sequence ID" value="XM_062829903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MN34"/>
    <dbReference type="GeneID" id="87867057"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="214"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3338195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="277" mass="30799" checksum="988276D1935DD9F5" modified="2024-05-29" version="1">MSGAADREAVFPTRQSLGIMKAKLKGAETGHSLLKRKSEALTKRFREITRRIDEAKRKMGRVMQIASLSLAEVTYAVGGNIGYQIQESAKSARFRIRAKQENVSGVLLPTFEAYQTEGNNDFAMTGLGKGGQQVQRCRETYARAVEALVELASLQTAFVILDEVIKVVNRRVNAIEHVIIPRTENTIKYINSELDELDREEFYRLKKVAAKKQRDNAETDAQMKAKKAEQQRLALAEAENAEGEQATEAPAAPEATDLPEDTPADILAAEEDEDIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPH4</accession>
    <name>A0AAE0MPH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_551528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3338750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062829814.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042254409" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9500" checksum="2BAC2133BCCEB9D8" modified="2024-05-29" version="1">MTLWLILFAARNATDTEFLAIARNPLSPVATNDMELTKDGNQQQSARKEHQQETRTPCPWPADDDFENINTKTKQAIAVEVDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPN6</accession>
    <name>A0AAE0MPN6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="501"/>
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            <begin position="687"/>
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            <begin position="751"/>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062826949.1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="504" mass="54588" checksum="2592AF9D8AA3E141" modified="2024-05-29" version="1">MPLKKSYSDAYAQPPKRGGWQRTRSNPAANNTTNKGPLQSLAPVSESTKNKLQAFRSDDTSSKPPKSAKPAKAAADELQKENINTTKSIPRKRPSPDSNDEESSDAKTPADRHSWKDLFGVPEATTEEEDGEKSPGDRVDWKSGVPLQLPASPMIPKNGKRRAKSSSPASSPAAKLTTPHVALKKIAGASKTPHADPASDLWSRFSSNGNDTSPSSHKNPLFAQLMASSSPRPQSGDRSLRKSVSCGSAWPKRRRTVCPDEEDRTVSQNTPRKKKSSLLSELLQSVDGEIESPKTTTNAPAQQKKSPSPKKKSPSKRKTAPQTVPDQNSSPSRKKAERQTTEAAASNLPEKASSDYGDDDFDFDEDTLLELDASFLGRGDGSTLIASDAVSPAPRESSKTVVDNDEFGDLDDDIFDGVEDLVAQVESATQQPAVRLSPRKRLSPKKRLSPRKRQSPKKLPQQVVGDEDDEFGDDFGNDFDFDAVEMAATQHAGHAQDASSHVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ87</accession>
    <name>A0AAE0MQ87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_277226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679911.1">
        <property type="nucleotide sequence ID" value="XM_062822831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ87"/>
    <dbReference type="GeneID" id="87859985"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="172"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="593" mass="66992" checksum="F1262C79415FB524" modified="2024-05-29" version="1">MVQTYGHGHYTRPQWMTERPTGEHMPDNGRYYDTGIRTPPPTISEVLREQCKINHQSFFLAVLTEDGHTVYFTGPNKLPEGEIQRYFDMDRFIRYQKRAAQNGLAGAYDEMSFGPEYHGRRGSDRRMETAEEFYDHAPPTYRTRKRQRANVPRRVRDDDEPAVTVSAKKGIRINNAQEVWDFYDQRFKKIQQNTCKLIAKAWIKAIAPKKQSTHPYTGTKIPDWWPKPLGPSKDEGMRHKEPDHLFKPERLRLLCHLLRLIVEPNSQQHPSIRAQELTVAKLEELTMEAMGGFFNDRANPNQAKKKPFLKEIFKVAKVEEQYKRGEIDGDTVVYVMADNNQSDFPSDDEDDACREEDDEHHLSVIPSRLSPPKTTMPHALMPIPTTDHSPTANIQPGFVSEMPIRNPYPTTLMPPDLTPDQHYVENGGISVGGQASLQQHGAPVQMQEMIPSPHETSRRPSLFSSPSDYASTTASGLYPGAWQQTTTAPGSATMYSFGTPGQQPQQPPHPPLPHPQGTFVSHQGVQIGQNQPPYMGSSFDTLPHTSNGLFRGPNVSQGSVSHGQSYPSYMQHDSRGLPGDMKMDPSNRGLPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQC2</accession>
    <name>A0AAE0MQC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_214348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680016.1">
        <property type="nucleotide sequence ID" value="XM_062821974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQC2"/>
    <dbReference type="GeneID" id="87859128"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042044177" description="Ecp2 effector protein-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="233" mass="25344" checksum="54E7686D3B910024" modified="2024-05-29" version="1">MRTPYQFVSCVAAILAASTVTSLVLPTDGSSLDKAPDGRPTTLPRNIATRDDAVSDNTTLHNDPFFYMASVDDDDDEIPDQTDLVPRWGPGSPPDKDDPAKVYCKDFEAITDETSEDSPLIDDCLSIIPNIQPPEHAADWRFMVGQTRVLVSYKTCVLAVSANDGVAKGQWIQVGNVDVIAVIQELASIRGKKTNNPSLVPGRGEKMGGKTSGKCMMRVLKKPSKTEFSIYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQK2</accession>
    <name>A0AAE0MQK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_252967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679190.1">
        <property type="nucleotide sequence ID" value="XM_062822502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQK2"/>
    <dbReference type="GeneID" id="87859656"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="239" mass="27157" checksum="9CF1F90F9A4BA889" modified="2024-05-29" version="1">MHPSYTHQLFFPRTMFPIQRTPFRCVAFQIRHSALRDSWRVLGIRCNRFSQDDTQLAEVQTQWVNRVFESLLFLILAQRRFAHVSSLLLLFLSSDTAANGRGSDAPVAVCQSHHVREDRLWITASSPLTSPSKRLENCQGSQSPTKTFWLPDNRLGTAGLGCWVEYSTRAASFTEKVGSRLNTYHDAFAGARNSRSIWKCIPPIWPLIITKSAVSTQGVQVIGLFLEHFGRLISHNLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQS4</accession>
    <name>A0AAE0MQS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_578089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679400.1">
        <property type="nucleotide sequence ID" value="XM_062830719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQS4"/>
    <dbReference type="GeneID" id="87867873"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11228" checksum="E92F197EA10DCA41" modified="2024-05-29" version="1">MTFKVIIVGGGPVGLYMAYAFERANIDYVILEQQDTVLNISGQLLFTWPQKVRLFDQIGLLADLEKVALGIHHKKRLFGDNGQVTTTGNFWDAMQNKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQT5</accession>
    <name>A0AAE0MQT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_472689</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679460.1">
        <property type="nucleotide sequence ID" value="XM_062827156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQT5"/>
    <dbReference type="GeneID" id="87864310"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="74"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3340518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="608" mass="66867" checksum="2350BF681279F840" modified="2024-05-29" version="1">MANSGQEHEIHYNLVEDDEFDIVNIVVEGLNEIPGASAPSVSAGVGLKSPNSSQPRIPGRPLSQKWLHEKLGKYPAKTHVQKVMEELDAPKSGLIYLRGFDEPLYPYSDQGPPFRQQRHFFYLSGADFPGCAVTYDIPRKELILWIRRNDPRLSLWYGTTPSIDETKSKSDVSDVRYIDDLTAYLHAVLTPETGGGPLYLLSPDQLPKLSPSPPQSNLFKGLHGSGSGGLKVDTISLLPAIEAARVIKTPHEISLIRRAVSLTSTAHKMVLQRIKHLTNEREAHAVFEGFCISQGAPHQSYAVIAASGPNASTLHYDANDQPLEGRQTMLLDAGCEWGCYASDVTRTFPIRGQWTKEGEEIYKVVERMQRECIDAIRPGRLYYKLHLVACLIAVEELMKLGILYNGTRAEILARGTVAAFFPHGLGHHVGLEVHDVSGRERLLLSGSTASSSGLNNQGVPGVSVSGSRRRMKREQVTPEDLAAICREAMMDRDDVEQNVVGPPPYKGRQRLKENMVVTIEPGIYFHRPYIQSYFLSNPSHAQYINTKVLDKYWDVGGVRIEDCILVTKDGYENLTTAPKGKEALKIINAGIPGFGGGGHTGAAAGGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRQ3</accession>
    <name>A0AAE0MRQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAM signaling pathway protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_187108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681456.1">
        <property type="nucleotide sequence ID" value="XM_062821589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRQ3"/>
    <dbReference type="GeneID" id="87858743"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="818"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="969" mass="106746" checksum="DBED45EE9616FD1D" modified="2024-05-29" version="1">MDRPRGRPDNPGLARRMPPVGAAHAHGNLPPHPPRRDASNSSLSASTPLSSNQVIALVRESMRVAHENEAKATEGISTLKPGLTIDLSRKRIQKLPDEVVDIIKDELERLALSHNYIQTFPARFSECTSLRYLNVRSNRIKEFPLALCDLKSLEILDLGRNMLRVLPPDIVKLSSLKVFSIQKNEVSELPLCLADMPSLSVIKLEGNPLVFPPPEVFQVPPPSVQNEGILKESELTEITVTAHVKKYLKAQANIILEREQAESPNDETDGIETPRPTIKRVFSGRFPIKVNGTDVPDLRSPNLSRPPPIPSRSHYRGLSQQSSAQRRPGVMPLTIGNPNERIRSNSETTGAHHSSRERSESRSRRMGVVSRKGSELGTLDELEAKDRFSIHYRGLSHGSAMQPGNGSMPGQSPAPSSPADSISLQRPIYVRRLSILPERRRESKFIDPVLEAAKGILYSIFQIHPMIQMLMGLANDGSSKRSSLEIVFYNTNAHVEQLELEIQKHDQAGDGTGPRENENVQRACITLVQAYSHVCSLLVNNVDLFLDNGDPRYLRTLLTQLYNSIMELRVTCSQPSPGMPSRNVPPVPHRPDLETIRPHSRDNSVTPTIDRPPQTARLRNPGPMHPHANLRVATDVPLMPYNNGMHRQVMSAVTPRSGEPFPVSAGGLRMSIDEEDRIFEKIFLALMKSAELALKVLPNLSAQFSVALRNATTQRASDHVVHCWKALIVKCNDSIRHTEILKERLSNIKLKEPGIRGQPGFWRMCNDYIDAWYVLGKKTMQFQTDIQLPVDAKSRMRPIQKAMKDAWEFMVHSPWSHFLKPQPSSGGHGRGRMRGRMGGPGMEGVEDTSSPYSTHGTNTPVPMPMTPQSAALGPAVQATVPSTPKNGSFSAAFNGGLFERAETLIQMGGPGMGSRSGTMQSTSTASLNSIGTTLSGESAMTPNSALRGSPGPGSLTPLPFRMNSGKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRX8</accession>
    <name>A0AAE0MRX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_466876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682113.1">
        <property type="nucleotide sequence ID" value="XM_062826880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRX8"/>
    <dbReference type="GeneID" id="87864034"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="109" mass="11842" checksum="F7A2CF712A0E1AF7" modified="2024-05-29" version="1">MGIHYLWVDAFCIIQDDENDKAAQLQLMAEIYQYALFIVVAAVGNDAQAGLPGVSIPREAIQQNVLVKKAESPELVFITYHQGLHPSIHCGACSCSLSILPDKAVGYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS14</accession>
    <name>A0AAE0MS14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_407777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682233.1">
        <property type="nucleotide sequence ID" value="XM_062823817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS14"/>
    <dbReference type="GeneID" id="87860971"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="120" mass="14104" checksum="F2A8A8AC928E1A1C" modified="2024-05-29" version="1" fragment="single">DRWTKEVNDRLLPLKEQKKSHKEIVKTLKTEFPFLDDLNENILAKRIASLREAAADPIKLDKSINRLMPAAIPLVASEFFKLAEEHGFSENVNRKREDIEIRMRAWYKAMVQSLILDMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS55</accession>
    <name>A0AAE0MS55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MLH3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_189538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681529.1">
        <property type="nucleotide sequence ID" value="XM_062821618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS55"/>
    <dbReference type="GeneID" id="87858772"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="681"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="965" mass="106797" checksum="5884A8BA3DB3129A" modified="2024-05-29" version="1">MSIQPLPGDVIAQIKSSAVITSLNGIVDGLLRNSLDAGATKINISIDYSRGNCSVEDNGLGIPPACFREDGGLGKLYYTSRYPPHPDFHGRHGQFLASLAALSLLSISSHHHEHRSHNSTTIHNSRIVARNTPALPEECVLAFPSGTRVTVRNLFGSMPVRVKQRATEVERLGTAKSLDQLIHIIVSILLSWPNEATLSVRDAVSRRTVTLRTSGITNQLQDRRNSANELVLRTSSLFAQASLTEEQDSKSWVPVGASVPGVSVNGCFCLVPVATRRVQFMSLGIRPLSNENDSNILYEEVNRVFANSGFGVIEEAALNEGQPRRKEGFTLKELKPRKGLDRWPMFFLRITMAGQEGSLNADDFLDERQQDLSIITDLLQVIAYEFLKKHQFRPKSINAFDRLKSSRGSSAESGTLGRSVSPSSSQATFSHNKKHTPSGLARSTSSSSRASSSNRHIEEGSASPFTSWSRVKSGSTHELQSKNFSSSSALSTDKTVKSASTSTQDVEIVPWAQNPLFDRAGKLIRKPFEDVEPPPSSNNHFAPRGLSRQSSLPSSFDSSKTDNYVEWVDPTTNTRTLIDPRTGFMIRPHSAPGTRPRDTPKRRPKGSLARAAVPASKSTAFEPVEAPIPRVPELYKSLEHGAHHSCNHHSTGVVNLEPVNGGALMTLQGRISRDALRTATILAQVDKKFIFVKMAPTETDKVSPSSDVDRSVLVLIDQHAADERVRVEYLMKSYFTIVHRSGASQSDQITAQTQSLQRPLRFDLSKQDGNLLVRYKPHFEYWGIFYEVFTGEEHSTRFTVEVQSLPPSILERCRLEPRVLVELLRKEIWRLNDNPGLGLSLNRAAGGGQIEGERDWVARFHDCPEGILELLNSRSCRSAIMFNDELSLEECSSLVLQLADCAFPFQCAHGRPSMVPLLDLGAGLVRASSDLTLPDDFDRTRTEDKGKNNLWSELSSWRRDKIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS74</accession>
    <name>A0AAE0MS74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_460149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682413.1">
        <property type="nucleotide sequence ID" value="XM_062826515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS74"/>
    <dbReference type="GeneID" id="87863669"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042171285" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="87" mass="9256" checksum="B3C09C04F7E0002B" modified="2024-05-29" version="1">MFLAGLLLLAAILGILGLIPESHSFKSSLPASDCLVLRLGVSSIFTGFSYRVANLWSLSPTFQGLICGGMGELGGGWYFLCGEVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS97</accession>
    <name>A0AAE0MS97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_467583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682367.1">
        <property type="nucleotide sequence ID" value="XM_062826914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS97"/>
    <dbReference type="GeneID" id="87864068"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000018">
        <property type="entry name" value="Heme/steroid binding domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="121"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3345754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="286" mass="32581" checksum="2DB8B9407BEDD1DC" modified="2024-05-29" version="1">MADTDTVRRRKPEPKTASQETASASEDSEVEEIIRPGFPPHSDSQNGGKKKKAPKRQIEDEDESNPWLLDILRVISFLFLASCGLSYLISNGETFFWGMSHPPNYLQLEWWKSQLRGPIYLTPTELAAFDGTDPSKPIYLAINHTIYDVSANRRTYGPGGSYNVFAGVDASRAYVTGCFAEDRTPDMRGVEEMFLPLDDPAVDNKYWSPEELKDLKRKEMEEALKKVNDGLKHWVNFFGKSKKYRFVGYVKRDKDWLKKEPVPKLCEAAGRGRTPRSPPEDGKKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSG8</accession>
    <name>A0AAE0MSG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_467173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682236.1">
        <property type="nucleotide sequence ID" value="XM_062826897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSG8"/>
    <dbReference type="GeneID" id="87864051"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="111" mass="12146" checksum="CC62E7FE4D4F5D4E" modified="2024-05-29" version="1">MSYNHTTGAASSAEASLIESAAMRMRVDGVLEAAEPALGPIVQKLKRQPNNLDTAIGNIMPMALEIVIQSISEEQRSPFNPTKETVKALKGYIALWFKRKVLLEEMSSDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSL5</accession>
    <name>A0AAE0MSL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_152041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682712.1">
        <property type="nucleotide sequence ID" value="XM_062821087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSL5"/>
    <dbReference type="GeneID" id="87858241"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="453" mass="50585" checksum="9F7EE28F4196AD8C" modified="2024-05-29" version="1">MEALKSKIESIKLQTQHLCNFAETNLQKSTPSSSSTQTDVISSAIQQVLEVLNRIDNKLNELTTTSSISSISLPSISYPSNTVGTHPIPNLVCPEDGFYGLSHGNLKKLSHGPPTKKRKLNATFLLHSKRQNFGQSRDISNVVSNSDTKGRDYEENEEQDEEEDQEQDEEQDEEQDQGQDKYQEHGNNENGNQNSDNDTDAAISVGCSDTQIKVDSNTKDTNTDTDIELGRQLASLTIDNGAILRFMSIVYAWDSADVTLKSSFASRKPTDELSTARHYDNLRRKAQNLSILYTVLGMSASFRLSKVMKENQHRHRASGSCISAVLAGRGIEDTPKARKAFATEISEARKIMKMVEGYDGLLCFLPLGFGSGFTLRALTRLSNKDLETFRATIARYKSLMLLSEVGNEFLLSVWGEGEFKERLFQRRQLGELQNLPNEDLIKFLTPIQPEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682431.1">
        <property type="nucleotide sequence ID" value="XM_062821021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSN8"/>
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    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="233" mass="26316" checksum="F2C289AA3F576491" modified="2024-05-29" version="1">MSSSSALRTLSHQGQQSDLIELENTCIGRASQIIHRDLVSTPGCISAASTAPTTHFTSPIASPLHILGPVNPAPFRPPSVNLEAQFQASCAQVIQSIRRQLAAEECLRRAVADILEISAAMIEADQERIDYIHRHITGLKQDIQQWERAGIYIDGGEHGDNWEIQYYLDQLPHLEERLALNRQRLDDYIARMAQVRDDTEQLRQKLRQELRDFQGEAADEEEAHEAVVLDEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MT37_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_538479</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682896.1">
        <property type="nucleotide sequence ID" value="XM_062829093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT37"/>
    <dbReference type="GeneID" id="87866247"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="413"/>
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    <feature type="coiled-coil region" evidence="1">
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            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3347814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="611" mass="68458" checksum="98BA847F6E06FA35" modified="2024-05-29" version="1">MSTPQATQEPQDALVQSIANLVNTTDALAEIIARVNNSLSETSQADEAFTVALVYLENVKGQFLNLVASAQEAASLNLATKLQIEQATKQLEQLQKKIKDQLELDSKEVAGHIKKQFELAFKVMSENFKKQLELTSKEMADDSKNMADKCVKALALTGEAMVEQVEKLEHTSEEMEKDSKKMSEQAKEEIKQMAENANKTIINSSEAMVDQIYNLEYGADEIQVDVREVKEQCKEVLGQSKEVMVLTMEELKLAKEDMQRERLLFKDQHDRLEQKIEEMYRVLEGRDAENKGLKALYSKLSSHALRSVQNATNFRDAQYKFLVDGFARFEQKIAFITHHIGNTSAISGKASTAVTTNDASKADKTSKSPKSTKEDKIAELQKIVRDLKYERDVLTGNNKLLELRLAKFEQEALATSPAPEQPVPDTPCPTLKSTKSKRSLTETGEPLAQLTLSDSETTTVVASARPSVESLIQPDLWERLIAPALLSDEIKRRLRLIKPQVTGGLRLETLFLRVVNIAVHDQAWENFDSLLKQGTISQWYCVDGLVKNGLGRGSTILVGHQCDGHRAFPQGRDAKDRHALGYGIWVIMTPHGLCRDVRPIPLQPVHKEYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTJ7</accession>
    <name>A0AAE0MTJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_545591</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683762.1">
        <property type="nucleotide sequence ID" value="XM_062829390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTJ7"/>
    <dbReference type="GeneID" id="87866544"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="143" mass="15624" checksum="0188187CC9105FE1" modified="2024-05-29" version="1">MHNNTSKKELSPLSTFLMRVLWLLYTSAAHCLKLLDATLWPAELETMSEQSQLPIDVYTELGKRYRKELPSLWPKKTTSKDSAHASQGKNEDAGRKKRKSAKEGGRAKKRTMVIEDSEEEGPTSSPLPVVAIAAVGAASVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTZ3</accession>
    <name>A0AAE0MTZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_463294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683479.1">
        <property type="nucleotide sequence ID" value="XM_062826697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTZ3"/>
    <dbReference type="GeneID" id="87863851"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="338" mass="38315" checksum="13CD33FBD3AD61C7" modified="2024-05-29" version="1">MSSPATGLLPGAHWAGQNLPEEDADNDWDSDIESSTASIKSSILQYRIINGRTYHSDSVTDTSYWGPNDEKQNEMLDIFHHAMTVALDGDLYKAPLTKDPKNALDIGTGTGLWAIDFAEKFPECSVIGTDISPIQPRWVPPNLQFDVDDYNKEWTYTANFFDFIHIRWLTGTVKDWQVLYKEAYRCCKPGGWIEHMDASGAVWSDDGTVEDDMAIGQWGKIWQEAGRRLGTPLDVFEKNIQEEGMKEAGFVNISKKTYPIPLSPWSKDKKLRDVGLYFYAGMNQDLEGATQFIFGNVMGWTKEEITAYIAKLKREIKNLNIHGYFPCRVVYAQKPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTZ4</accession>
    <name>A0AAE0MTZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_572252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683494.1">
        <property type="nucleotide sequence ID" value="XM_062830503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTZ4"/>
    <dbReference type="GeneID" id="87867657"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="277" mass="30812" checksum="FFEB9E5ADE756B98" modified="2024-05-29" version="1">MAGAWDEGSEGALWCVEVLFHPSQREEGEGTPEATVHVCPWRWHLYAVSFIVFYEHGAQSSYYPVVTGCSKPHKRLANEGRMCLHGSLVGLDSQVMNTPAGPRRVFHGYRVLHTLLALVEGGADVGLAVAAQAELDLEGNGTAHEEVCAVNQLPGPAWMIDDMFEWFLEVETPYEQPVPFLPSLSHPDLQPSHLRFFLTKKFTYIGLATQADAPNILTYLFNLSDTKTRLRDTTASSRSYPWYKCISTIAKALSDPDALQHIKDEALHIAEGTEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUJ9</accession>
    <name>A0AAE0MUJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Complex I intermediate-associated protein 84, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_456745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684321.1">
        <property type="nucleotide sequence ID" value="XM_062826313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUJ9"/>
    <dbReference type="GeneID" id="87863467"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="835" mass="95909" checksum="0677C515FB8A856D" modified="2024-05-29" version="1">MRSHLARNATTTPNVYRRFHAAGHHHGLLRPCSVTALSARRCLFDCQHDVLVYPRTSKRTFISLFTPKPERVVKLPHFDPGYNVLLQYRRSEVEQERPPPRDQLVTAFRRLTKFKADTNKPLNPNQAFLLRTVLHYLLVTKPEADAPVDLKMSDLENAMDAALLPPKGSPEFHLALARLLHEEITRRRVILLNPDEHKAHLIKDDFATYIKALTQYGGSLEAAARVKEFWQQLKDEGMSVVDFRGAGRVWINVLQGMADEGREDELLQFWEEAQETGGVKYIPAVHHVFVTFYAKQDKIEETKQWYNKPIHSGFSPLGETLLELVRSSRRSSQPEKWNEWLLPVFEEVVQDQWAKKGSLEAFLQWSVLALDKGPDGIKTYLQTMASGEFYKSHEVKVDVTTINLLMQAAQEKGNPYMAERFWQLAQDFNIKANVHTYLNQLSYRLDANDIEGAHQIFSKLASGAVEIEFEEDLPVMNKYLRVLCAQPEPNLQHILTITSALEQRHAALEPETIVALCLVFLNHDKKFDVIDTLSLHSVSISHIERQQIYKAFVAYICDLPKTTTDRAWDAYSLLRQYFPETSVDDRVRLMESFFERKKPDMACLVFGHMRAHDDDNMHPTADIYVRCLEGLARCPVPEQRPSDPASSLKMVHNMLKMDTRVEMSTRLYNALMLAYAAGGDPFTALDFWEEHITRSAEGPSYNSLAIVFWCCELIPLGDRYARPVWQKMMRMDLEVPQYVFNAYCAAIARSNAAWGRKMEEVFKLIKGTDSNLGYGASMMTLGVTYNALPDPFSKEEFAAWAKEEYPEEWVRLESKGQKETEFQGPVFNITRPFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUT9</accession>
    <name>A0AAE0MUT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_507217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685158.1">
        <property type="nucleotide sequence ID" value="XM_062828122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUT9"/>
    <dbReference type="GeneID" id="87865276"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54382" checksum="9E581D80F3702222" modified="2024-05-29" version="1">MELASDPRAVVGLSNAAKLQASSCSAEYEASDVLRHYRDLNADANILLQFVFDLCESSRQRFLPSLMSLLGLALGPQTVPSQLDYDDFDNFLAALNAIDADPTGKGDLAASFASLASELPPHLSPLHPGADSAVIREFLLVLADRTVWSLDMGGQVNSSATKQFFELVKMLASSGGPPPPPPPETNSNNSTEPDKPSSYMTWYRDWMPKSWGSERPAPLDVELTLIRSRWRSPRLFGMRLLGTGHEMQPLKTLLDAFKEVGYLDTQEGKVETLMSLAEGQGTDPLQPWESRPREVGLVVEAIRYALALSSTTTTTTPTTTPPPPPPSLRDALTKLDRLKILPRAAQNKGNKELLAWLLDDADKQGGNLREALNTANYIQGESPTNRNKRVWLRNYVLHTAILSGDADMVKLLLERGAKMLRNNEGRTPLAFARVLLGSRITYPGMKEKVEVLEGWLRERGLDSEYWDEPEEYALDVSEGFEFQIPIQEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUZ2</accession>
    <name>A0AAE0MUZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prokaryotic phospholipase A2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_421920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684786.1">
        <property type="nucleotide sequence ID" value="XM_062824369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUZ2"/>
    <dbReference type="GeneID" id="87861523"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042114659" evidence="1">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="188" mass="21100" checksum="ECD683A4BC9ED936" modified="2024-05-29" version="1">MKFFSTTLALSSLLPTAAWAWAGSSESDSTGAGGSLFRRAETIQQTTDRYLFSITLPQFTVYRNARNPATLDWSSDACSYSPDNPLGFPFTPACDRHDFGYRNYKAQSRFTDANKLKIDGNFKNDLYYQCDTNGYGSTCHALANVYYSAVRAFGRTTGELQEEYDLLLAHYNELVAEAIDKGEDPLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVS6</accession>
    <name>A0AAE0MVS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_23275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686133.1">
        <property type="nucleotide sequence ID" value="XM_062822208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVS6"/>
    <dbReference type="GeneID" id="87859362"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041958755" evidence="3">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3354755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="261" mass="27994" checksum="2B5AEF32BD7F82D1" modified="2024-05-29" version="1">MKSTALFTTVTMAHMALCVPVPWMAGDKILPLLNKDAPNSATSGRSPKTDNTFALASSHLAPGPILQKAEQSFNSLWDNWKKKHGSSPALNVDDAKKDIPVLIITEMGELSVAIPSSSQPLSKQASNSKQKPVSIPPGNKKADNVSVTELGELSIGIPSPVPSPPPSSSTSLPSSSRPSNGTSPCPFYVGKPRDHDDVLIIFLVSTFLLVVVVVEAWDPVCRSVRNRFSSRRKGAIRLVEETETKPKSFRNDSVLVKSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVT3</accession>
    <name>A0AAE0MVT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_437681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685686.1">
        <property type="nucleotide sequence ID" value="XM_062825326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVT3"/>
    <dbReference type="GeneID" id="87862480"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000222">
        <property type="entry name" value="Raffinose synthase Sip1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3354308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="874" mass="96968" checksum="612D9C210A124DE8" modified="2024-05-29" version="1">MSPFVATYPPLEQITQLKDASVPFHAVLEVPKSLAADSWQLALWHSTGSCDGPKASWVETPFAPSGQSNFPSTLHDPADQLTRLHFAAHLTVQSSLSFTIKFRQGPDYDWRWVRNEQGLGDGYIVVDDGAIERSDGEDLPDLIHGLNPSLKWSSHLSQCPGTRLWTIGVPVDGAKDDDNSTFSDVPLGTPWGGFLRWFALVRDWSPWLAPRQGRSTVELDKDALLCSFLSPKGKHLVFLGFAGINKAVDGMTLFRSDESGRLTIHVRNDSVEAGSGTVLVAVGDNFESANAAVMYHARGLVSTAERAGESSTELETLSDNVEANWYENWYDGLGYCTWNALGQRLTAEKVIMAVDALADNNINISNLIIDDNWQDIDYRGDQWQQGWNDFEAEPRAFPNGLKGLVSEIRSKHKNIEHVAVWHALLGYWAGIAPDGNLAKRYRTIEVVRGEDSSRKNIPLGGKMTVIAKEDVHKFYDDFYRFLSESGVAGVKTDGQFMVDTWVSPKVRRELIQPYLDNWLLASLRHFSGRAISCMSLTPQIIFHTQLPRGRPTMLCRNSDDFFPEVPSSHPWHVWANAHNSLLTQHLNILPDWDMFQTAGAYAGFHAAARCVSGGPIYITDVPGQYDLDLIKQMTGVTPRDRTVIFRPSVLGRNLDQYVNYDDLSLLKISAYNGRAVTGTPIMGIFNVSGRPLTELVPLARFSGVLPSMWYVVRSHQSGKVTVPVQTTSSASLLTVTLDNGGYDILSVIPLSLYETETRGRVYVASLGLVGKMTGCAAMLNHSTDLLENGRLFISTRLKALGVLGIYISHLPELSIQDEFMATIQGQPIPPHTVTVDKTDNHVLDIDIETAWKEMGLDAGWSNEVEVKVYFTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVT4</accession>
    <name>A0AAE0MVT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_459925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685399.1">
        <property type="nucleotide sequence ID" value="XM_062826497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVT4"/>
    <dbReference type="GeneID" id="87863651"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3352104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="210" mass="23117" checksum="09C6F7BB0AE11302" modified="2024-05-29" version="1">MISLSALLHIIDMAPTRKNGVALLGAPGVSHSTSDDTVIEQRFLAPRISRSLDHYHCKRPSIRTSSPTSSSTRAMYFTTVRSFHAIILPVITLVVSGRPPTNAFHMNSSPTLPLYPLAAVPLGVNQLGFRAHIETKIVVVCHTSVHSPSESGKIQDTQARQGKIPVQGRAIRRWLGLEWIPLCARSGHPFDFCLLVSPFRRACRPSPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW47</accession>
    <name>A0AAE0MW47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_19093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685986.1">
        <property type="nucleotide sequence ID" value="XM_062821636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW47"/>
    <dbReference type="GeneID" id="87858790"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="338"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="563" mass="61927" checksum="C115C4D30C6EB593" modified="2024-05-29" version="1">MGMRTRSAAKRLKVDTDEHIVVVSPLQKSVIAPNHASVTIVASIEVDSRTRGKRKRGHATQAQPLEVKGGWDVLSHGIDALPTPGITPEVPYSLSGSSDTPMYATRSVTKRQTQSPFEVTKTRTENVETQNTPIGTGLLQGNTPVDSPVHHTRSVTKRQTKIHLGTIKARTENSNTTEAVETTGDAAPGKIIEVITPKNDRDEERTTRDRRVTRSSSKKPDTATDETFQSGNGQIIVKSTEKTTKVTATKTPTVDRDSPDYRMPVKRGPDNPMGLTPGFSPYPNREVPASEACGDVYRILAAIHGKVEQPKKMPKASLEKAGCGEVPCVLDALLRTLISGNTLMAMADQAIRNMVQEYGLREHGSGAGSINWENVASEPEEKLAQVIKVSGNGNQKAKNIKLILDMVALEMAQMARENNGMGGKREVAFPETLNLDHMHTLTKDEAMAKLVRYPGIGIKSAACVALFCLRKPCFAVDTHVHRFCRWLGWVPEKANAEDCFKHCDVKVPDHLKYGLHQLFIRHGQQCFKCRKATKPGTKEWREAPECPLEHLLDRGKGDARGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWE5</accession>
    <name>A0AAE0MWE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_504887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686271.1">
        <property type="nucleotide sequence ID" value="XM_062827954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWE5"/>
    <dbReference type="GeneID" id="87865108"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="334" mass="38331" checksum="40D92EBA24AF6F64" modified="2024-05-29" version="1">MERAFNHQKWDPIRKAYPAYRKLWKATIHDRMHIRRTPPPPDSDDSSPPPPRPRRSPRERPPTPVNPYDAERGYFSIPATAFFWSSPSMPHLSSSNELSKADHSKGQAAASPHYFTVLPMQDLIIIRPSIWTPHMHEGYWRAFEHGFPFGAENHGFPGFCGWKGFAIEYDPSWGQKPEFGAFGHNRATWWDNGSLKWPDGTVGIFDIIYDAISNFSDYEQIQTIWLIDYRLKPKHHTPTAIGRPDNTKRVFHGGDGCQFVEIYSEFVESGGDYLNGYYTEGIDRENSAMGEGSCHWFIEEFEACMFGDLYDSDESVDSNYSRYPPHIGLLACLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWY2</accession>
    <name>A0AAE0MWY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_414113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686781.1">
        <property type="nucleotide sequence ID" value="XM_062823887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWY2"/>
    <dbReference type="GeneID" id="87861041"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041994698" description="superoxide dismutase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="183" mass="19098" checksum="9ADFBF2DA20DF044" modified="2024-05-29" version="1">MHLISLLGLLATATLAVSQSSNNTTGKLGDARPVRNNPVIGEVWVAKFDSPTVKGFVTAVANTVGVNYTIDVTGLPVDQGPFKYHVHLRPVPSDGNCADTAGHLDSYLRGDSPPCNSAAPQTCEVGDLSGKYGTVTGPSVQKSFNDPYSALNVINLGYIGNRGIVFHDASSARIACATLQKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX72</accession>
    <name>A0AAE0MX72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_73887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687661.1">
        <property type="nucleotide sequence ID" value="XM_062831346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX72"/>
    <dbReference type="GeneID" id="87868500"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="37"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3356284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="203" mass="23081" checksum="444854D4D805CF15" modified="2024-05-29" version="1">MSSLLGRIFRSLNTQTLKMSTTTFPSSPVHVPEGAEKATVAAGCFWGVEHLYRKHFADKGLYDARVGYIGGDASNPSYKQVCSGNTGHAEATLLIYDPTRLSYTQLLEFFYKMHDPTTHNMQGPDVGAQYRSGIFYHNDEQKKVAEEITKKANEQWWGGKIVTEILPAKEWWDAEEYHQLYLVNNPDGYECPSHVLRKFPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXI4</accession>
    <name>A0AAE0MXI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_64334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687334.1">
        <property type="nucleotide sequence ID" value="XM_062831203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXI4"/>
    <dbReference type="GeneID" id="87868357"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="534" mass="59858" checksum="018395A034C552BA" modified="2024-05-29" version="1">MAEEQTRPELVRLPPSSRFGRCDHGRFLENVQSILSVGQATLGEVTVDCRFLFTKSKWGKMGTDPSSSDTYPAGILYLDLDFSEPQDCRLQSAKVAVTLGVDEKSSKTDKSNPVYPATMTGHYGPKQLVGSEKTIKVQRTKEFMPHIDVPPYVSVGGMGISTEEAKDVNDRWRFAGHLRPAKGSFIYNRIEWDLHESALEEISSHGCEFHTAFAISHNAKAFHMIVEVKGDLVRKRDQFKQFMGSAKEHLKFGGNKANQAVVKFQWSKEYSSPKRLDRQAQRLPDEMERENRCSIPSEIPGPQQTTIFPATDSNPSVGLLEQVPTSMANGTSNGRFWHAQTLEANQRVRTLELIGEMVIAAGLESLAECGLLPQYSRSASLQRCESSSDVTLVESGRENESVRGPSPESRRRSKDVGMQPGSRAWDLTSTPRDNVKEGQLETVKAGILLGLLYWLQGLMVWEKFVSRFGVTADTTESDRNKAIRDKNDRGRRPGNKRLEPAPRNKQQWGEESEADTPVWMGSAHLRGKRREEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J043</accession>
    <name>A0AAE0J043_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_410378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676674.1">
        <property type="nucleotide sequence ID" value="XM_062823830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J043"/>
    <dbReference type="GeneID" id="87860984"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="183" mass="20261" checksum="CE9967B4CA0EB434" modified="2024-05-29" version="1" fragment="single">HPWRLPSPGLWLDISQKIKAMGFNAVCFYVYWSLVEGQRGEVRFDGVFTLDGFFHAASEAGIYLIARPGPYMNAEVAAGGLPGWTLRIKDPLSLSGETGRRKIIADAQITNGGPVFMYDTWPGINDTDFPARLNRDNMVHTQRLVRKAGIVVPFMHNDHLAQGNWAPGSEPGSIDLYAIDAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0G1</accession>
    <name>A0AAE0J0G1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 monooxygenase ABA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Abscisic acid biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase aba1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_81704</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Hormone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676546.1">
        <property type="nucleotide sequence ID" value="XM_062831450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0G1"/>
    <dbReference type="GeneID" id="87868604"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000076">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6 18" id="KW-0349">Heme</keyword>
    <keyword evidence="11 18" id="KW-0408">Iron</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3334380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="526" mass="58707" checksum="CB9A81CB802B09B4" modified="2024-05-29" version="1">MALTELLGALPLVSSGMPKFQVAAIYLAIGFVSWYIISSTTAWYRLKAFPGPPTTGFSNFWAARAVWTGKTRKIFPETQEKYGPITRIGPNALMVCDAATVVNINGVRGGYARPKDFYDCIRMDPWDQTVLSETDSAMHNERKTKVYAGYQGKGEMDLEKDVNMVVSEAVELVRTKYMHSATSGPKPPLDYTRIARHIAVDAVTQTGFGKAWGDVREEKDHFGWLGFADMAVGYVHTLAYIPAISKIVLSKPLMALLGPKPTDKTGMGAYLGLIEREVARRYKDGEAKGRPIKADTGRSSMLDEWVKHGVTQRTAVLEVSAQLPAGTDTTASALQGTMLYLLSTPSAYSRLKSEIATGIREGRISSPITDQEARKLPYLQAVLNEGIRMMPPLMNGFPRQVPPEGDTICGKFVPGGTDIFVNYIALLQDKSVFGEDAHMFRPERYLEGDEEHRNRLFKTTDLAFSHGRWRCLGQKLAWLQLQKVTVEFMRNFDMQIVDPMHPCNLRCHCTPEMDDLMVRITEARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0J6</accession>
    <name>A0AAE0J0J6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_566160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676840.1">
        <property type="nucleotide sequence ID" value="XM_062830312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0J6"/>
    <dbReference type="GeneID" id="87867466"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="457"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="390"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3334674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="665" mass="72236" checksum="B3595BE73928B676" modified="2024-05-29" version="1">MDANHTHNCCCSSRRDGPQSPLVSPSPGPLTRSLPSTHSLASALSPGASTPGSWTAHPWSPESANTSPPSTRSGSPELKVRFQTEKVNTAPRVDVTEVLPTVTKSVKSICFVGAGFVGGPTAAVIAYHNPDITVNVVDLNEQRIAAWNSSQLPIHEDGLLKVVRTARDGTLDTMVKIPGLPRSLKLDARSPNLVFSTKVNEAIEVADVIFICVNTPTKTYGLGAGSMADISMVESASRTVAQHAKKGAIIVEKSTVPCGTARVIQDIFKYYRPNDDFEILSNPEFLAEGTAVENLMHPDRILIGSARTLAGMKAAESLKNVYAAWVPQERIITVNTFSSELSKLVANTMLAQRISSMNAVSAMCEEIGLGSDVDDVSLALGQDSRIGPKFLQAGVGFGGSCFEKDILNLSYLARELHLDVVADYWLGILKINEYQRERYVHRVVKELNGSLRGKKISVLGFAFKDGTNDTRNSIAVHIIKSLAEEMPLEIAIFDPGCAADEIMEEIGKIGLTKAQLERVKICSNWRDSVKQASAVCILTQWKQFRGSQLGTKASVKTPSKPAITKTFVNGKLTEMAILELEAMVARDLNITDEDPLRRLKPEGAAEGFEIFGLAAQMMEEISQEPVNWFEAASLMQEPRWVFDGRNVVDAIELQSLGFKVRGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0X1</accession>
    <name>A0AAE0J0X1_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_446906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676801.1">
        <property type="nucleotide sequence ID" value="XM_062825829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0X1"/>
    <dbReference type="GeneID" id="87862983"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="206" mass="22813" checksum="E6BAE31F37E2072F" modified="2024-05-29" version="1">MGVFEDRACHQQDKKTTMTTPPPRNRDFYRIRFTCPLTALPSPFLPHLTTLWVSFVANFDLQAGIPWPAVATNPCAPMSRPAMPACHESDVKLPREISPHFPGRGQEGRSSLEVRLFRREAPATGPTTNAYLNTRLRPAAPPGPRRRVLDGFYPGVVSSSETVHVPFAAVGISMIRIALQPPKDGSRRSLRLVEANRFLSCISISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J0X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_335615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677035.1">
        <property type="nucleotide sequence ID" value="XM_062823563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0X4"/>
    <dbReference type="GeneID" id="87860717"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042020094" evidence="1">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="137" mass="14738" checksum="AC67AADBBD5F70B2" modified="2024-05-29" version="1">MKATTALRAILILTSSTSTVSAFSAASTPDSPPSLEDTLHHNELGFAFNHLPRQVSTGQELQAFFSEKPLGGASSQPIVFSGNPERPFEVEGDTFPDFPTAANRVCDKQKNACAEMANDASEVKSFRVSDCDEQRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J140</accession>
    <name>A0AAE0J140_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_565976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676768.1">
        <property type="nucleotide sequence ID" value="XM_062830305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J140"/>
    <dbReference type="GeneID" id="87867459"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="168" mass="17078" checksum="D34994661DCA5822" modified="2024-05-29" version="1">MGTSRVSMPTPGGGYASTPEESVYPDIWGEDNNPSNGDNAVFSDWSGDGIYSYANSYSGLYGYTGHAQGHLSIFNNGSSIASGSSVAKASSVAKASPIAKGSPNPKGSPIANSTANPFDPPAGNVPVPVDQAGDETDHANRAEVAGPAHKGRPPIIIKSKCEVCKAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1A7</accession>
    <name>A0AAE0J1A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_341618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677260.1">
        <property type="nucleotide sequence ID" value="XM_062823656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1A7"/>
    <dbReference type="GeneID" id="87860810"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3335094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="603" mass="67079" checksum="DA6C1CE291CCCB63" modified="2024-05-29" version="1">MSVTVEEPQRGPEEPSKLRDTAKETSEQEPDNVDNNADVKKATEPTQYGQNDKRDRGAPRIVMAYIPASAPASPIPSHNTPAPGRKTPEASNGGGRPVTPNLTAKLNQAIHEYRAREERVGDLGQPDDEGYEGDTNSPGAHQGCCDHDHEHYHVAHRDEQYSPVYQQQYCNGHTPPFNAPWGWTPYHPAFSPPLNMQPPFRPPFQHQQQNYANPHHQPTTPSTYHPPSFPFPYHPHPYHFPHPYQPMHHHQHFSIPPPPPPHLFAPPPPTHPSDPRISPPHFHPVSPYASSLPAYPTPFPPQNFQHPQPQDPHVTELTQRLQNIQAQLNGLDAAHEVEIWRHGKYNFHRRRAKQLRKIKREKVEEMVTVVRELRALGVSGGQFGGRQYPLHMQPQGQQETQGMCWTPRGSGYGAEFEQGWGYGQETGYWPGYGHEHEHSWFGEGHGHGQAGSWSEMEQDGGRCGCSDDGAYVDSPRERDSAFESMACECGCTTIDGEAGPEGESSEALPPPSPASSKQTSTGITAGDVVTPGGTRARALSLDGMREQVEAVESHGQQHGDANENEQGESVEKNSSRERAGSWSDAEAVISEELRGIWRKKMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1D3</accession>
    <name>A0AAE0J1D3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_330945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676918.1">
        <property type="nucleotide sequence ID" value="XM_062823509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1D3"/>
    <dbReference type="GeneID" id="87860663"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3334752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="172" mass="19194" checksum="449A46EB10B6856B" modified="2024-05-29" version="1">MTGLDPDQDAIIEIYCLITDEQLNLLDRTGWGTVIHQTKARMDAMDEWCTRVHGNSGLTAAVLASTVTPEQAADGLLAYIQKYVPNKRMALLAGNSVHADRAFLRKKPYDRVVDHLHYRILDVSSLKEAARCWCPHVASGAPAKKGLHTAKEDILESIAEARYYRSAIFQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J2L8</accession>
    <name>A0AAE0J2L8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_341094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677242.1">
        <property type="nucleotide sequence ID" value="XM_062823646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J2L8"/>
    <dbReference type="GeneID" id="87860800"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3335076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="145" mass="15875" checksum="C4C472FB13A523F5" modified="2024-05-29" version="1">MSLSTPEILTAYDAVRSDKSPINWLLLGNATPTSQQLTLKATGEGGIPELIKHLNPTEVAYAYVRVQYANDAESVRVKFALIIWIGEQTRVMRKARVSIESGEVKKVLAHHSVTVDAGEVRDIDEEEIVKRARKAGGADYNGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6T6</accession>
    <name>A0AAE0J6T6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">DUF1774-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_581363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677400.1">
        <property type="nucleotide sequence ID" value="XM_062830814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6T6"/>
    <dbReference type="GeneID" id="87867968"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3337949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32820" checksum="58757B9A39B4E210" modified="2024-05-29" version="1">MANFSDLNPFAKREAHSPTSITTYKVLTLLSWVLSVVTTVYYDFHSPHDGHFIRRTIWGQNYAHPSGFTQNATITSIYWLVLFILQGGYIGHLFSNDSSTVNAAASVGSHFIFNNLLHFGWVMLFVRSHFVWSEILLIINFINLTSLYFRHSAYPKGIHMPAVSGPLAWTFVALYWNGAIMVPAQHSFVARIFANVFIWSILVYGMFFIVTYKDYTMGFNLSVLAASLGVAQFFDRVIAFQWIFAFTIMAVLFVFTVVVAVPAWTGKEVSWGRRQTQPDAERAPLLNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6X9</accession>
    <name>A0AAE0J6X9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_552558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677504.1">
        <property type="nucleotide sequence ID" value="XM_062829896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6X9"/>
    <dbReference type="GeneID" id="87867050"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041781175" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="26"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3338053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="647" mass="72528" checksum="A193213B01077A9F" modified="2024-05-29" version="1">MQLKNHAPSGALLASLLVAPQIASAFYLPGVAPTTYKPGELVPLYVNSIRPVAAPDALLHSVVSYDYYQPHFQFCQPEGGPKSVGESLGSILFGDRIKTSPFELKMKQNETCKMLCPTTYKQGVAFYVNDKIRQGMSLNWLVDGLPAGQRIKDELTGTEFYNPGFLMGQVDGDDHVIFNNHYDILIEYHEVSGNPDQLRVVGVLVQPESKKYTKDIPKESTDVCLSNFEPLELKEDGETKVQFTYSVYWIPSQTAWATRWDKYLHVFDPKIHWFSLINSAVIVVFLTLTVMSVLVRALRKDIARYNRLDQINLDDLSGTSALEDGVQEDSGWKLVHGDVFRTPSYPMLLSVFLGNGAQLFVMTGFTIAFALLGFLSPSNRGSLGTIILFLYTILGFVGGYTSARIYKSMGGEKWKMNIILTPVLVPGIVFGTFFFLNLFLWVKESSGAVPFTTMLVIILIWFIISVPLSVTGSWLGFRAAAIEPPVRTNQIPRQIPPVTTYLKPMPSMLLVGILPFGAIFVELYFIMSSIWFSKIYYMFGFLFLCYGLMILTCATVTILMVYFLLCAENYNWQWRAFLAAGASAGYIFMNALIYWASKLSLSGLAGSVLYIGYSALISFLFFILTGSIGFFSSWWFVRKIYSSIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J744</accession>
    <name>A0AAE0J744_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_435340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677609.1">
        <property type="nucleotide sequence ID" value="XM_062825188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862342"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="778"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="966"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="584"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1242"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1262"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1274"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1303"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1345" mass="147611" checksum="077D110DD56AF165" modified="2024-05-29" version="1">MKGNSRHPSVPPPPPAPQSPTSKATAKYTNKDGSKFITVPKGSTPADSAQPSPTITTAANAAPGPQSASTSHTQGHGQGQVEGQVQPVNKKKAKRRQKAAAKAAATQGIANSAPSNGFPSPSPSNAQQSTEADHDDSQDEHPEEFNDRRDSRTSNTHENGFAQGATTSSKKSKKKKKKSNATAELPNSPHHDAYLSAPHLSQQQRSGISKEKIWNTSSQEERERIKEFWLGLSETERKELVKVEKDAVLKKMKEQQKHTCSCTVCGRKRTAIEEELEGLYDAYYEELEQYANHPNQGEAPPMLGRRPSFGSMTGMRPRGLPTSYSSHHQPSHGQIVDHGAEEDDEEEEVEEEYSEDEQEEDDYSDDEPSEELHRSDYPADFFNFGNSLTVQGRDRFPILPSFLQSIPSPGTSNNAYGSSSLGGILTVADDLLKNDGKKFIEMMEQLAERRMAREEDAREQFNSPFPHSTNGDRNAHYHPPADDEVDDDDYDEDYDDDDEEEYDSGDEEETMTEEQRMEEGRRMFQIFAARMFEQRVLTAYREKVARERQNMLLEEIADEKRRTEERQVKKQKEAQKKKERQARKRELQAEEKARREEEKIAEEKAKKAEEDRQKEQRRQREEEKRKQKDAQKKAEEEERKRKEAERQRRNHEREENERKAREAREREKKAREEARLKEKEAREQKEREAREQKEQQEREKREREAKAKAEMEAAKAAKEKSKQEDRAAQKAAALATTAPVPITLPKRPAQPAQTSVPAAVPALPQQPAVYASPVIPVATPAFPKAPAPAQSRQTHQQESVTTSSGSTSQPGSAASQNPSPHTLTPVHTSPGPMKPPSKPGIVVGGTQSSGVHLPSPAPSATVNAGPKSLQSQPSPFGGPSMNMPFQPTPQPPPGFSNHMQPQYPPFYNPANSYNRVAPGMMAAPPGFPTPLGGRAMPMHPPGFPGPLDSPVSSFAGLPSGLSSLIGKDSVPSHARQGSGSFETGLVGSSSQPISRPTPIGRPASVVHGQRRSPESSTNGTDKAEQEVHLGSSALLEPDDTQQDFPARPHFGLLGTSAPGARPAPGFGGGPFGMEAGFPLPHQNNPWNPVPPLQHNPFVPPPPGFPSSSHHGPWSQAAPPGIMGRNPSIVERSAPRSVTLRKALCAVCEDLGAGGSSSYDGFIPLGEIMVHMKQFTVNEKEVLDICDTEGNPSNGGGSFVVRDPLSPTGTPLIRYVPDDDASRAPYRPIKHPGDIGSPIVGSGTDSARLRNQSGGDQFSRRLSRSETVAEERHSTTSQFVSGWRSSSQSATPVAQGQNNLDTVSSGRNQGRSSSSGQDNPDTFLFGRNPGAQQGQRNNPERNKWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J848</accession>
    <name>A0AAE0J848_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_474671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338817.1"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Neurospora tetraspora</name>
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    </organism>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678435.1">
        <property type="nucleotide sequence ID" value="XM_062827302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8X1"/>
    <dbReference type="GeneID" id="87864456"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3339075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830148.1"/>
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    <dbReference type="GeneID" id="87867302"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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    </feature>
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            <begin position="84"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3339314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="252" mass="24851" checksum="4848C5EE1CEDDBDC" modified="2024-05-29" version="1">MHLTTLIVTSLAAGSASAFHWGTSAPPAGFGAAAAATDAVAPAPAGFSDPPSGPPPPSAPGAPGAMRRPVQAADADADAAVTAAEDESDCEEEDESDDEGEDDDAVVASSTTIVCPTPTNFIWNGAPVIVTASTVLTLPCTTDASGATAAPFHPPPARPPHGPWAAWGSAAESASAAPAPNSFTTPCDTWVTQTAIATATATEMVIPVTHAEPTWTKAPAQPTVVMAGAARGYPAAAAALAVVAGFMGLFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J9P8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678277.1">
        <property type="nucleotide sequence ID" value="XM_062822920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9P8"/>
    <dbReference type="GeneID" id="87860074"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="531" mass="58931" checksum="234E210BF89C2FD7" modified="2024-05-29" version="1">MSGQQSNLVVGIPNPTTKTTPHTPPESPTETQIKAVDGVEQQKQQQQEPQDNGPQQLNIKKTRGNSTRPDSLTIPLSATPGNHNTIEVPATRSPDAHADLYMHNLSASPSLKERRLSRNSFGASLPIPRSKRQSRLSSVTFPGVAEALQDATGTLPLKPTREFLADRVQDIHAEKVEKVKNMSFVFDIDGVLVHGDRLIPEGKKVLDMLNGDNELGIKIPHIFLTNGSGKPELARTEQLSKILQNPISTDQFIQSHTPMRALAEYYNTVLVVGGEGYKCREVAEEYGFKDIVVPNDIVAWDPSIAPYRVFTDEERATSRPRDFTKCNIEAIMVFSDSRDYATDMQIIVDLLRSENGRLGTVAKDPVSQRIPIYFSQGDLLCPTEHPTPRMSQGAFRIGLEAMYKALTGVDLERVVYGKPEMATYKYADEVIASWMEQIHGEEKIPQNIYMVGDNPASDIVGGNLYGWNTCLVRTGVFQGGENDEENPANFGVFANVWEAVTTACRKELGDDFNFKWDDRVNPLNMNASAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9T0</accession>
    <name>A0AAE0J9T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_552045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678671.1">
        <property type="nucleotide sequence ID" value="XM_062829864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9T0"/>
    <dbReference type="GeneID" id="87867018"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="480" mass="53287" checksum="7B0D1F5C1D0BE883" modified="2024-05-29" version="1">MPKTTAATSKRRHNPLEADLVSTGVLKNNSGKKSKKTRADNDEDEQKYVDAKASRNILAMSRSLIEEEDNLRTTQNAASGSAPSAFEFDPSRFDRNDDEDDKFENDEAWGEEEEEEVEEIEVDATDLETFNQFITPTMNEDPLLTHGWDGKPEGAEEQGQSVNLADLILAKIAEKEAGGPQGGYRDEPGPIDEDYEIPPKVVEVFEKIGMILSRYKSGPLPKPFKVLPQIPHWEDILPITRPEAWTPNACYAATRIFAAAKEAVLQRFMEMVILERVREDIHETKKLNVHLFNSLKKALYKPGGFFKGFLFPLAASGTCSLREAQIVAGVLTRVTIPAVHSGMAIKGLCEISSAQASQRLDCVSATNFLLKTLIEKRHALPFQALDALVFHFLRYPAFATGGHMAPNALPVIFHQCMLSFAQRYKTNITEDQREALLDLLLTHGHDKISPEIRRELLAGRGGGVPVAQPGFDGDDTMLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA76</accession>
    <name>A0AAE0JA76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_511705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678871.1">
        <property type="nucleotide sequence ID" value="XM_062828510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA76"/>
    <dbReference type="GeneID" id="87865664"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3339511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="167" mass="18264" checksum="3770F4F06275086C" modified="2024-05-29" version="1">MADTDKGLPVSCECGYIKFQTPSSKPLGMACCHCTSCRKQSASFFGTSVYFPASEMFPLPADLESKLSVFTHPADSGNTMHCYFCPKCGVRILHAGVLPDGSMRPAVSIKGGVIDSGLDWKEMKPRHIYTRSAVMDLPEQWECYETTAPAQYGPPPGDNGKDKKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAS4</accession>
    <name>A0AAE0JAS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_252815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679183.1">
        <property type="nucleotide sequence ID" value="XM_062822499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAS4"/>
    <dbReference type="GeneID" id="87859653"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="104" mass="11487" checksum="2BBC43F6BED9FBF3" modified="2024-05-29" version="1">MFLSLFLCLPNHPCSNFSLSLSLSLSQLASLLASHPLHCKFFSLFPSIQHPVSYNAICVTIHHARPQPPPLQHLLLPTSFLPEPDLTQQQASTTVPPPLRIRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB03</accession>
    <name>A0AAE0JB03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAR2 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_510269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678997.1">
        <property type="nucleotide sequence ID" value="XM_062828384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB03"/>
    <dbReference type="GeneID" id="87865538"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.550:FF:000007">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="200"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="409" mass="46871" checksum="53FA37764119D93E" modified="2024-05-29" version="1">MAITTSESLLGFRDIPAGTHFLWVQQPGATSRNGYWYVTQEQNGRVHVKQWDPYNEVLSSLPNQAEERHQAENLEFIYPKLKPYDMRGGSKRSSAKASQPMPFSIAGRNEPSFMTDPAKMWQQLTHAISEPFLTRITGEKSVDAWLVDSADCAAGESYRAQYKSVQSSEFHFLFAQDFKDLELLDSDPTRRDVVEDTTDRVLALLRNTDFSFDPYDIIAELQFTFLTGTHLGNHACMEQWWDLVLKIIVRAYRLVLFYPVLTVELIRTLHAQIVYTEENVESTSEEEQEKGRSEHTIGPSPDRPIYQFNLQNRRRLRTALATYARKLEEVLNGLGDEVTIEQSTARAIFGELEAWLFTRGWDLGSKNAKVEETKRQDEIGEDDDDDDDMPVVVDLDEHGREVGLVSFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB28</accession>
    <name>A0AAE0JB28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_267689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679635.1">
        <property type="nucleotide sequence ID" value="XM_062822705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB28"/>
    <dbReference type="GeneID" id="87859859"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="723" mass="77689" checksum="56466BC8BF2E4726" modified="2024-05-29" version="1">MDTGTQLPPPSGCWLPAGDCPPAKMSRPSSGVSPIQQFPGHTFLSSPPQTCRPTLEHQLTTAAQHQLTLPSAITSPYSDEQLATPGNRLSLLPTGTSNPDPKRSMKPSPIRPVAGPGSGVQRGAVGAVGQIPGAVGQVQVGSVGLQVGPAPGQGQVPASRLTPGPGPAKVTKPTTPARPRAVASPHSLVRNSQLVQQLAAHEAQLQQFQQQQQQQLQQQQQQLQQQQQQQQHQHQQHQQQQNVATNLSPDQDPNNVGHIHPQLQAQLQLQHQQAQEHDLHNHHLQQHQQDQNQDHLQHQQEQHQEPDIDQDSLKQDPSAFDDPTARMGTEEYAAAAAAAVMETGLGQPGSLNDGTGEPDVDAEMEDQDASAAANSGLGGHVDLTGANMLGNPGGPGGVPQPSPQDHSQHQQHQHQQQQHQHHQQQQQQHQQQQQQQADMLQGLGQPQAHPHQHQHQPPVAPMGQPQQMQPSPHQHSMDPQLSKSTEDMAHESGYGQLNVESALAKRLAREPGHRLAQQRRPEQVLNLARRSNVEALFAHIAGEPARVPCKNCHKGHGPWTSCIVVDGQMCGSCANCWFNASGARCSFHETRNPQNAQQQQHNTAILPNGANGGINIPSDPNAFRFGTPHPLGTHAALAAPAPVSAIAPAAPSMSNPMLQHMLNRAMSEVRSADKATRQLILIECTAKKLALQMVDYEELISSQEQSGNAGGPGQQGLGEDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB81</accession>
    <name>A0AAE0JB81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_260705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679421.1">
        <property type="nucleotide sequence ID" value="XM_062822611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB81"/>
    <dbReference type="GeneID" id="87859765"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="981" mass="109609" checksum="8FF424E7988E73CA" modified="2024-05-29" version="1">MEPLPLPTSLAEVEQLIIALYQPNPPETVSRIQEVLQRLQKSPEGWQLSQSLIGNPNDNIKFYAALTIIVKLNKDSANLTDDEAKELLQNILSWTIASCAQGVAPFVIKKLCIALVTFFIHFSQLWPNCLRHFLYSLDLGRATPIEALDDAVETTFIVNNLEISKLKVAIWFATSLVEEVGKTDMNSIKYVHVHERLVRNAPDLALLLARGFLPSDDTYQTQGESLVCFQAWILYAQRLSSNTDVLVTHLRELVSPALNCFAIDDLFQPASELFSDVLSNYSGFFTESHYASLASLFDSEWAAEHYNRVIHGDHQLDGISFGLLMLAYGDAKVSDLMCSTDERSQRFLGRLAGLLAADGYLVGEDSIFVPALEFWATFVETMIDNIYSEEEAKVNVWRPHAEQHLKSVVSNCWRKAQWPPAETFAEWDSNERVGFTDARKDIADMLQSIFTLENLTLVSFFSGLFLQALSVQSWAEVEASAFCLGSLSDCITEDPQYDVELSKVFASPFFDLLGQAQGPVPLRLRQTCLLLIERYCEYFERHFEYLPHALNLLFAAVGDPVLGGPSAKSISTLCSSCRCILTSEAPAFIMHYQTIRSRQVLDSLAEERIILAIASIIQAIPDSDQKLAVFENLYSIIKADCERAVQLKHQPSMLNLSDPNFLRGVEQPGDVPSADAVSHELAVRALRSLQSMAKGMQDVKEHVVDIDADPSSTNQDPKLSAIQSDILNVLVEMQRTFNTSGEIVEIICIIFRAGFSETESGPFVFPPEVVTNFFSQQRFETPRLGTLLSTACSFVGSLYRGPKNMIPSLLAQLLPWVINMLSSLPEPESDTEVAQNGICFVDKIMTRYPEVVFQIQPSQMLEFFFMFSLKVLNGKEPLPKTASAEFWSNFITLKSESPDLQGTINNAMEHLGPLISQTLIQNIGGNAARSELDKLSDPLKKLVASQVRSRQWLEQALFDQSFPSQQVGSEEKSTFLKKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB86</accession>
    <name>A0AAE0JB86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fcf2 pre-rRNA processing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_430763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679423.1">
        <property type="nucleotide sequence ID" value="XM_062824899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB86"/>
    <dbReference type="GeneID" id="87862053"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="210" mass="23070" checksum="2128B900678FB204" modified="2024-05-29" version="1">MAASVLGLSDAEIDKLLAEAESRLANPDSSNAVTAPQQDAAVAPAAQTPVVVAAPSAAPAEVVKPTLENKSKKLSVRVPQSKEKTKGPKNDAGADWFNMPRTNLTPELKRDLQILKMREVVAMGKQYFKKDARKDFVPEFSQVGTIIAGAADGRDSRLTRKERKRTIVEEVLGAQVVDKYKNKYHGIQEKKQSGGKNFYKKLVNGRRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBH6</accession>
    <name>A0AAE0JBH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_530077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679919.1">
        <property type="nucleotide sequence ID" value="XM_062828917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBH6"/>
    <dbReference type="GeneID" id="87866071"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="214"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBT9</accession>
    <name>A0AAE0JBT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_551426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679973.1">
        <property type="nucleotide sequence ID" value="XM_062829806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBT9"/>
    <dbReference type="GeneID" id="87866960"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3341031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="265" mass="30401" checksum="E069C9C2FF9C8877" modified="2024-05-29" version="1">MDHENQYNYQRIDLSTDAIRLGVPYGALSYTWGDSPDAYEIFINDRKSLVKENLHMALLALRQTDEDRLLWIDAICIDQDNDKEKGHQVGQMRQIYENAEQVLIWLGPSNRGIDSLMDLARRWDYQTSQRPGAHRAQGWIDSWIKLTADETGPYKEELTANLETLLVKFGTSKATDHRDNIYALLGIASDARASNTLRPNYQVSLGRAICHTISFLLFDEAYDPSARPLPEDMDFTTFLRILPKLSDYILGWALQTSAPRHPSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCE4</accession>
    <name>A0AAE0JCE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_428004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680041.1">
        <property type="nucleotide sequence ID" value="XM_062824723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCE4"/>
    <dbReference type="GeneID" id="87861877"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="49388" checksum="0D8CB5225C42D8E0" modified="2024-05-29" version="1">MSSSLITKTALTAATRAAPRAAAALAVPLLRRGFASVSAAPVTGTSRSHRIVVVGGGAAGLSISHQLLRTGKFSPEEIAVIDPAQYHHYQPGWTLVGGGLKDALSLRRDEASLIDPKLKFYNQAVSQLSPETDSVTLANGDKIGYEHLIVVPGIEITYDKIKGLPEALADPSAPVSTIYGAHTVSKVFPTIEKLKRGQAIFTQPAGVIKCAGAPQKVMWMALDHWKRAGLYNPSAPESGAIQIAFATALPAMFGVPKYSARLEELRKERGVEGLFAHDLVEVNGNKAVFAKGAEKITREFDLLHVVPKMGPYSFVKNSAVADAAGFVDVNQATTQSTKFKNVWSAGDASSLPTSKTAAAITSQAPVLVGNLLRSLEGKEPALEYDGYTSCPLVTEYGKVMLAEFKYAGVPKETFGGLPVVGGALDQGTPRRAFYHLKKDFFPWVYFNAMVKGTWAGPNGWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCG5</accession>
    <name>A0AAE0JCG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_428386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680289.1">
        <property type="nucleotide sequence ID" value="XM_062824756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCG5"/>
    <dbReference type="GeneID" id="87861910"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="44"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3342496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="523" mass="56851" checksum="DC8E08976D2A11C1" modified="2024-05-29" version="1">MFGLGRQRKAESEASAQPVDHHNVDTVVNEGQTRGKTNWKNLIPVIACGAGLFSDGYINNVIGSVVTILDREYEDIWRNSNAKKYVGDIAFAGTVVGMLLFGYLSDKWSRTNSLLVSTIILIIFAALAAGSYYKGDAIGMFNILTAWRFFVGVGIGGEYPAGSVGAAENTGELKSGQRNMWFILFTNSMIDWGFVIGAFVPYVVSAACHNGHLSTIWRTSLGIGVVFPLVLFVLRLFVSEPEEFQKNSMKHARTPYRLVLKFYGFRLFIVSLIWFIYDFSAYSFGIYSPKIVANIYPDGSPLTTIFGWNTVINLFYIPGTMLGAPVSDLLGPRYALALGVFLQAIVGFIMAACYSSLAQPGRVAAFAVVYGIFQSLGELGPGNNIGLIAAKTCATGIRGQYYGLAAAVGKIGAFVGTWVFPYIEAAGGGDERLAAQYPFWVSSSLCVLSAALVLFCLPHIGQDTIQDEDARFRAFLEENGYDTRQLGLRKGEEMGMGEEGVEGVEGVDNVDDVPVEKRASPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCJ4</accession>
    <name>A0AAE0JCJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_226392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680472.1">
        <property type="nucleotide sequence ID" value="XM_062822130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCJ4"/>
    <dbReference type="GeneID" id="87859284"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="716" mass="78418" checksum="96FE4F4C347ABD6E" modified="2024-05-29" version="1">MEDPAPKRRRTSPRSSVPVPSDEAPTTQQPNQTTPEDTPAPESSSNTSAKRPSYASPTKASLQRHNPEVLQRRESLSLALRSQSESRDDNPLRSPARRLGIARSPERPNPRPLPPPAPEDEEVILNPFRGRGLHRSPVPGVLPKVIVPEPDLPPTPEHPDPVVSTPPSGIHNTPSKRPRRSKALAETLRSSSPTKRAPIMSVKAAQLVPGKPSEKSAPTSTSEIPTESQEPTTAELRGLQPPDPDADKKRLRDSLLAEIAELERDLAVASKENERLRQAHISKQKPSAPPNAIEILDLLRRRVLPPKEQKDPDPSAAATSWLSSALHPIAFLPFSKPPSTGDELPSLFSTTTDDLDKTSSSEKPPISHHPLPMTADEALPYLQVFTPLTFTSAIFPLPPSESESSTTSPAADERPLLQRHHITATTPSKSFTARLELTVNTSSTFSITNLSVPLIHPPTAAAELAPFIERIVSSQPTKEEELGLLNSALHNNVSVLCWAMGEWLRVAKERARVWCVLEAELNSGKEAVRRMVSGWRERGSKMMRQKRRRRGMGNKKRKAPTRRDKGGEDGEEGGSDEDDEHDEDGEGEEEEEEEQDGKKISDPELVPYMSRTSMDYDIPLLLGSGPGGAGGVGGPGSEEKSSLRVQWKIEFDWTGEARSDIRVFVALPGKWHKCDERGQLAKIPALFDELIQGGEEPLSAVRTVAALLAGEPQPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCZ9</accession>
    <name>A0AAE0JCZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_509638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680356.1">
        <property type="nucleotide sequence ID" value="XM_062828335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCZ9"/>
    <dbReference type="GeneID" id="87865489"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="610" mass="65715" checksum="8C39343816C355CB" modified="2024-05-29" version="1">MASAVSLAGLEKSYDYVIVGGGTAGCVLANRLTEDKDVRVLLLEAGGDKTTDPLVLTPGLVPAVYGKDEYDWNFQSVPQSTLNNRIINQARGKMLGGSSALNFMMLVYPSKASIDAWAAVGNPSWNYEALKPYLKKFATVDVPSASTKDICALTYNNDTVAYGDGPVQVSFGEGYGVTNKGWFDTFASLDLLSKTDARDGQALGAFQNANSIDPATKTRSFSAVTYLTAEVRARENLKILTNTHVNKVLFDTTGSEPVATGVEINVNGTVSQVSANLEVILSAGALQSPQILELSGVGGKEILAQHDIPVVIENPAVGEGMQDHPIVCQSFEVNEGTPSGDVLRDPAVVQALLDMYTADRSGPMGQLTISVAYTPLVNKTGVVSDECVQELFAGRDFSNPARAAVRDIVANPNEPTFQYILFPTQVHIADKPENMATHLIPVEPENFLTIMTILNSPFSRGSVHIQSSDPKALPVWDPKFNDDELDMELLARGVQFVENLVAPDTAMGKLLNQTGRRLPQLKGDDLETAKEIVRQRQISVFHVSGSCAMRPRDEGGVVNERLQVYGAKKLRVVDASIFPVEPAGNIQAVVYSVAERAANLIKEDRKAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD82</accession>
    <name>A0AAE0JD82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_468877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680441.1">
        <property type="nucleotide sequence ID" value="XM_062826983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD82"/>
    <dbReference type="GeneID" id="87864137"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050276">
        <property type="entry name" value="MshD_Acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617">
        <property type="entry name" value="L-AMINO ACID N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617:SF20">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE RIMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="103"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="264" mass="29664" checksum="588AD5BB6B11BCEF" modified="2024-05-29" version="1">MPFIRPFEPRDTEACMHICRATLPPTLAADPVAARMSPYIWCLQFTHLSPQTCFVLVDDTSSSSSPPEDEKVVGYVIGTPDVHFFASSSYPRYIQDVLQSPQGLIDVPPPKQLDHLESWLLVVETDSSESGEKKKKKKEVLKKVNTESLAQHACNPRWLVLEGPEGGPAEERKRELVEGWRAMLHIDLLEGWQGRGWGRRMIERFVEGVREVVSSSGGKLDYGRGVYLGVAGENTKVVKFYEKVGFRVFEGGEVEGSVWMVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD85</accession>
    <name>A0AAE0JD85_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_428327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062824752.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87861906"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="85" mass="9385" checksum="CD86816DE795886C" modified="2024-05-29" version="1">MAAWFLAAHSISFAPQPSVVLKNVELKGSTMGSRKEFEEMVGFVREKGIRPVVSKVVRGLDNLGGIDELFEEMKEASMPSQNDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDE0</accession>
    <name>A0AAE0JDE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dfp1/Him1, central region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_239334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680865.1">
        <property type="nucleotide sequence ID" value="XM_062822298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDE0"/>
    <dbReference type="GeneID" id="87859452"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="633"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3343072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="697" mass="77510" checksum="9ABF5009DE4ADB5F" modified="2024-05-29" version="1">MSTTTTAASGTKRAPLSDNPNAANSPLRGSSATALALQGSKKAVRSHADQLREEPYGQPPPAKRQMIEHGGQRAAASPTSSRSNVSNVTRKTSTMSRTAERERAERASSRTSTTATSTRAERSHASTTTTTDRITAKELEDLSIWQTSMRSRFHKMVFYFESIPDEQRHKLAKQVAQLGAREEKFFSIEITHVVTTRPIPPVRPVQDENQPGTSTQSTSEQPKTIDPSLLNRNGDSVRRKLIFDKPSIRKSSVQPQEETMPKPKARSTDILHRARDMGKKIWSLDKLQRILGMVLETDLVKAALLGRGHTPQAADRAKARHQTANVLQMLQNERVHGPSDRDPTVVTKDIHYFKGPYIYVYDIEEKTRPVMVREYHRVADKKDGEWPQFRVASQGRCPFVEDYDPPERTRRERAQAKEKVTKAADTAAATEKAAATKTLQPPEVPSPKPVTGKRTLNEMEAPNDRAAEVVDDAPETVESTKESTPSVDFRSQNAFMSYTTKVGRLVAGEPVASGIQANKLTSAIRSQMVSSTTGVLGAKAGISKEVLGLQRKVLQKASVPSLSQDSGARRLAEIGVDGNPSCTRAASLGNPANPPMPEIWEDDEARKQEQAKKERKLRRTASTPAPQTKPKPRDPKPGYCENCQDKFEDFDAHIVSRKHRRFAENDDNWAQLDALLGKLSRAPREPRYRSVDDERWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDL8</accession>
    <name>A0AAE0JDL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_429300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="10"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680713.1">
        <property type="nucleotide sequence ID" value="XM_062824813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDL8"/>
    <dbReference type="GeneID" id="87861967"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000077">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 10 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="16">
        <location>
            <begin position="491"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="150"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="272"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11 12">
        <location>
            <position position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3342920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="824" mass="93401" checksum="3735CF24CA32D649" modified="2024-05-29" version="1">MTSSRDSGLPAQPNLRVTIIAADGLYKRDVFRFPDPFAVATINGEQTKTTQVSKRTLNPYWNEHFDFWLIERSKVNEDSILAVQVFDQKKFKKKDQGFLGVINVRIGDVIELAPDAEDQMLTRDLKKSTDNLVVHGKLIINLSTNLTATMSRLGPPPSSSRPSLLTPQSSVISNDRANERPSSAMSGPNGTANNQMNLASRPVSVAVSSSSTAPAPGTNGTAPTNPSTLVPAQARHHSTLSPFEDSMGRLPAGWERREDHLGRTYYVDHNSRTTSWNRPTGTGAAENRTAEANTQVERQRHQNRTLPEERGGANSPTLQQQQAAATANAATMMHTGATTPGTGELPAGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRMYGGQNNTNGTIQQQPVSQLGALPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPAMRIMSGQCHIKVRRSHIFEDSFAEISRQSATDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGINPEHLNYFKFIGRVVGLAIFHRRFLDAFFIGALYKMVLGKAVSLADMEGVDADFHRSLQWMLDNDITDVLDATFSTEDERFGVITEEDLIPDGRNIAVTNENKKEYVDLMVKWRIEKRIEQQFQAFKEGFHELIPQDLINVFDERELELLIGGIADIDVDDWKKHTDYRGYTESDEVIQFFWQTVRAWDGEQKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEITNLPKAHTCFNRLDLPPYKSLEMLQQKLTLAVEETMGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDS6</accession>
    <name>A0AAE0JDS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_428108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680803.1">
        <property type="nucleotide sequence ID" value="XM_062824734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87861888"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="664"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="855"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1271"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1288"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1388"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3343010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1405" mass="151861" checksum="F66C60BB6BE1C2D0" modified="2024-05-29" version="1">MEGRQPFVLGSAGVSGSGSGSGSGGGSGDGVGSQPGPGLQEGPSDRGRGRSHDRTSVPAPADASASFRDGGVTAPLSVPDRSVQNTAQDTATITVKAAVKATTLPLAVESASLPALAKMPASSSSLSLSPSPSPTATATSTSTDSGTGSGSGNGNLRPAARPAATVRAVTPEPAEVTFDMSAQSGNANTAALPHRPGAFPPISPETSPRSIPGAAGPVMSTTAPAPIPVGHPSGNPSGPVTATPSSLPTRRQGMVFGEGLAGSLDSASSSPPSRPSLSSFRPRTHTLDSAFRQQLVIENRHRIGSVSSSGSVAVVDDSRSLNSYGPPDTHQIAAAPGHKERKSSTARTRLTKKSAASQSSSPFSSPQPSVDSLPLPVPTRDANKVLLLMKNLCGRMRGEAQYLKDIGGPWYCGICYIDEEKGSLVSDSGEGSSSSLSLLIPDLRGCRVLPLSRMERGGRPSLEITSPHLNLSIILRPSAAEEYDLWLAALLCWQQLRPSGTKNTITRSGSSVALPPLRSEMQRRASSSGLREATVIKVGRVMLWDKGLATSPRAIVKRPSARDLRIPHMAWKHVSCILSDNGELKLMTEQDVSLLAMIELSQLSRSAIQQLDKTSRLLFEAWFALLRAFAVPDIYGLDPTSRGRVYEVTNLNSAPKGEVFRVEKTIKVRVTEAKLRNRTFPQEGNLMERQGKNIAELDPIIGNYFAEVILDGEVRGRTSTKSNTKNPFWREDCEFTDLPPSLPYLSVVLKRIVGNTESFSHQLQATLGLPKAGQLSEVLCGAVDIPLHLLERGKDHEQWLQVYDARQQSIGTMLLKVHHEEVVVLHSKEYQPLSELLHRFGSGLTTQIAEVMPGNLRKLAEIFVNIFQVSGKATEWLVTLVEEEIDAIGNQTASKQPRFNQRLMSNDSIASTDKIRQTVQDMSRTLPGEASLLFRGNSLLTQAFEFYMRRLGKEYLEETLAEKIREINELDPDCEVDPSRVQNGDDIHQHWAKLIELTSAVWRCIALSAHRLPSEIRHVLKYIRAVAEDRYGHFYLTATAVYTSVSGFLFLRFLCPAILNPKLFGLLRDHPKPRAQRTLTLIAKSIQALANLNIASKKETWMEPMNEFLHKQRQPFKEFADAVCAIPAESTSTSVPAPYSTPLTILGRLLPLAREGFPSLPYLVDHARNFAALAKLWAKIHPESDWDSSNCEGDLLHFHRLCTALHQRAAHCFSQMETRRSAGETTSKPPDERLRLSDALDNLSYDDVLGMSAHSNATGTFWIDGESIAPGSSGSEVDGPIMGGGSGSSSSISSRDIRNASSAIRQGSKSSEQLSSMSGGTVKGLRNGMQAPRKFLTGFIRKTRTASPEFGTGGKENGRERDRGAELEKDSKEKHSGKDAKASSGKSQGDRHRTGVHQHWHEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDV7</accession>
    <name>A0AAE0JDV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_528053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681145.1">
        <property type="nucleotide sequence ID" value="XM_062828885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDV7"/>
    <dbReference type="GeneID" id="87866039"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041907051" description="DUF7580 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="3">
        <location>
            <begin position="461"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3343352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="725" mass="80938" checksum="8AB64F3BC3E7108A" modified="2024-05-29" version="1">MSGFEIAGIVLAVLPAAVQAFQVYKTYFPSSKKFQEDLKQLVQDLESERTRLYNTLERLLGPLLDETTTSQELLENPHSPKWEKLGPRIDDQLRTLLYITYNKFKEQLDEINKSSEELRLKLKLPDPRNGLVYDQPVKYLYRDKRSILKAWAARTGFSLRKKSYDTIIGRLKCSNTLLEGLANTALEQKITRTLRSKDHVTRLLRDLLKSLFMALGDASSGCVCPKPPDVYLELVSRKDLWFAKEVESEDEVARGKIGFHLVLNSASLGQTVADGSPRLQPRWATFRVQCCNFGPSSPPLLSPMSPSNSTSSLPVLSTAVSNSHQPSGGPGKIRFTGRTSLPPSILMSQHPHRDPPHPTPAGSTTSLPSYMSGGPVGPISSQEGPRPSSSGKIKFRGPLTKLPAHVLERSIKLGKKVAFSTGSSTSVATLAKTSFSSFTSLEPTKLLNLCEITLGKGKKRASDQDYCHGCIVAISQGRKFALYPPREQDDINLKYQQQSIAEPVEFQTTLTLRQILDSDLQGAHRVPRPRTGDKIRMAVAISESVLHMHSMPWLSKPLTLDDIVFLVNDSSIASERFKLRTFISKPVGCTPSDTKSRHDGNPTVTPSPFYPTAFYLGLLLCQLMLLEDRKLPIATEIDLKAHQVPIPPGAVVMPDSMHKKLSRNAESLLWENEESAGEDYKNIVHWCLVTHNSEKGLDDEDFRKSFYAEVVEKLREKFKHMIYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDX5</accession>
    <name>A0AAE0JDX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_239759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680878.1">
        <property type="nucleotide sequence ID" value="XM_062822302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDX5"/>
    <dbReference type="GeneID" id="87859456"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3343085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="225" mass="24536" checksum="94D8A7E5D694A77F" modified="2024-05-29" version="1">MPCSCRLSAVGPSLFRDALSASAHECFAPSQRLTASKPGCIKKVMLQSGTRYHSIGQAPHDRLTFAVDPSRVSTLTRPPTSTLTFTSFPSPTTEPLDRIASISATLRVCERRPVCRPQGGFSQKADCANEPFAREHDIHTVTPSSDSSTSSSCASVRRWRARDAGHPRHISAAQLTQYRAGRCTSEDAYLPSWPIQQFRCPRKGLFSLLARHVSSVALACTFGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JED5</accession>
    <name>A0AAE0JED5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_427063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681248.1">
        <property type="nucleotide sequence ID" value="XM_062824662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JED5"/>
    <dbReference type="GeneID" id="87861816"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="73" mass="8154" checksum="D8C489E22EE96991" modified="2024-05-29" version="1">MSSYAKWYRPHCLSVPDYLHEPFFRRPQPIIRGKNGTPVAARLVIPPDIDAISGALVEYAAVIAVNPRPDPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEL9</accession>
    <name>A0AAE0JEL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_464743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681474.1">
        <property type="nucleotide sequence ID" value="XM_062826770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEL9"/>
    <dbReference type="GeneID" id="87863924"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000701">
        <property type="entry name" value="Pentatricopeptide repeat protein (AFU_orthologue AFUA_4G07240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="85273" checksum="BD61838459AD5A67" modified="2024-05-29" version="1">MKVSSRFDGSICGTIFLHRPSWNWSAIAASATAIDATSSVSQTSQRDQGSGRRRQVATAGLGPAQQRRRFHGGWSSQSGLVDGAARRPIRGSTGCPLLTTSSLRATPTSLSGTSSRRALDSNFFRYSVSAPQKKSHTAAAAAPVSEPEPEPVAAAAPEPSADQKPADSVFFSAPSALHDDLSTESHSGANPQSQEPLEFHYIKPGHLTKEELLELVDPYHGLDGTVEDHLKFIRDPHMHNYAPADRPRFTFVQNEDDYEYPGPDEVVGLDEYGQHTLSDLRFAVLMRLRTPHKIDLDTIYDLYQQLPEPRMPYINGRLRHQLLKALGQPQRRNSKSMLRYFAVIADVRNCSMPLTAGEWNCAISFASRYVGTVTETQAQSAMRLWREMEVDAGIKATEVTFNILFDVASKAGNFTLAEMIYKEMVSRGHYFNRYHHVSLIHFFGLKRETGGLRAAFREMVEAGEMIDTVVLNAVISGLLRSGEEAAAERIYARMVASIAKWSEAPFPTRSYASDRAITQALKMMARVAKKAPELQHSFQEMVPMHPNLRTYSILVKYYGVRCGDLSCVAKYIDEMKLFDIPVHGSIFKVLFKAFDRHGGYATSAWSARRLESIYSALLEAVDAGRTLVHHSTPPPADEESYPDDHVQEDHLHEPVQVQEENIQEEHHPESYDPEAELPYEEEDYQQKKEWGVDRPGVEIKTWLAIWVLRAFMRCTNGDRVVEVYDQLRARWELSDKDELFMADFLSSLLIDGSRRGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEQ5</accession>
    <name>A0AAE0JEQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_539178</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="15">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681313.1">
        <property type="nucleotide sequence ID" value="XM_062829112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEQ5"/>
    <dbReference type="GeneID" id="87866266"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="63"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3344700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="458" mass="49796" checksum="74F74EAD06BEE7BE" modified="2024-05-29" version="1">MVQISEVKGNSRDNRTAAHTHIKGLGLNSQGIAEKQASGFVGQTTAREACGVVVDLIKAHKMAGRGVLLAGGPGTGKTALALAISQELGTKIPFCPITGSEIYSTEVKKTEVLMENFRRAIGLKVRETKEVYEGEVTELTPEEAENPLGGYGKTITTLLIGLKSAKGQKKLRLDPSIYEAIQKERVTVGDVIYIEANTGACKRVGRSDAYATEFDLEAEEYVPIPKGEVHKKKEIVQDVSLHDLDVANARPQGGQDIMSMMGQLMKPKMTEITDKLRSEINKVVSKYIDQGVAELVPGVLFIDEAHMLDVECFTYLNKALESPISPIVVLASNRGMTGIRGAEDLVAAHGIPPDFLSRLLIIPTTAYDPEEIKRIVKIRSTTEGVKITEAAIDKIAEHGVRISLRYCLQLLTPASILAKVNGRNEIDVQDVAECEDLFLDARRSAALLSSEQGQNFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEU4</accession>
    <name>A0AAE0JEU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_426509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681301.1">
        <property type="nucleotide sequence ID" value="XM_062824635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEU4"/>
    <dbReference type="GeneID" id="87861789"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3344688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="487" mass="53733" checksum="9B625FF8DD2D53A6" modified="2024-05-29" version="1">MAASESDLMTFYQRFQTLSLFNDSSARLIEDLLLYSKNVEDALREENRALRRQLTDSQLDLDDATRSRRELQQQVANAESRNRDLAQDNHHLKNNNPFVVVLIDGDCCLFKEALIRQGVEGGKKAAYALRSAILEQCGDFAGNIEVIAKVYANLGGLAKAMRRNGCLEAEETLKEFTIGFTQGKATFDFVDVGHGKERADNKIKAETAKWNLRNYNCKQLLLGISHDAGYAPFLDELFQDETKKRRVTVVEGVPTVRELVSTGVNILNFNDEIFRSEKLVDKTALRTNTSPLTATAPVTTPTVSNGNIPTPASSTTSTPANATASYAGAIGNASPPPKITLPIQPRPVNANARASATPKQPAWNPGPRGLDPPIKVSPAALESIKKRKDNNKLCNNHYLRGPCSKGDACCFEHKYKPTKDEIDAIAFLARLNPCTSGQDCDVEDCIYGHHCPNVKDGVCTHPYCKFEDADHPPGTKYRSTKTYDYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEX5</accession>
    <name>A0AAE0JEX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_192802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681639.1">
        <property type="nucleotide sequence ID" value="XM_062821669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEX5"/>
    <dbReference type="GeneID" id="87858823"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="901"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1158" mass="124082" checksum="6C70F20D3686F57A" modified="2024-05-29" version="1">MFLDRHLPRIHPIGDLVETVPNQAASAGNCLLLKSSTMAAASSHNNNNKPTCPRSPVDPSTDTPSYDESPVSSATSAKPHAPQQQYLGGLTTVPRTTPASSVPASAPHPPSPRSLPQPPHPPRISILASSSTESLLNHQPSHQNSFRSYTPATATPFTMGGRDSLPSNDSVSGTPGPSSGHQLPSSSSQAQKRAYRQRRKDPSCDACRERKVKCDATDTTSCSECSSRNVKCQFTKETNRRMSSIKQVQDLEKTLDKLKRENLNLKRALETQGHGVHGHASHGLGRGQPHMPMDRMDIDSGPVGGMGIEQLLALLLPEIGAEPKPKKRPVPIPALAQARSNIRIPAKGVWKPPAQYRHSPAGPSMFDYTPRPELPSQQTTDHLMRCYYSSAHTMTPIIHWPTFRQEVDNLYRPGGLSQHAPTSFLAMFYAVLAVGALFSSDPHRSYRAAEWIEASRKLIDPWGNDFVLDHARSLVLISIALNELNLKSAAWNWLGNAVKVAQDIGLHSDMGSWPLIEKEMRKRTWWSIYILDRSLSLELGRPMLIDDVDCDVPLPMGVDDHFIRDNGMVVPNGAEPLTHSLLAITHVVRSYTALGRLLSSSGNEGPMLHNRNEFMSPAIPPAWLATFDQYFASCLRTFPPACDPSSGSPLAPVLLNPLIYLLHARLLLHRQNLSPQCPPEARLLAVEQCTNIALETAAYLKRMTPTLPEGATALTTMHIFRCALFLLLIGHLDQALVCIRELATINTNREVAVPCGRYLLFFVGVVGQKRSEYLQRIMMTGSPEPAPVRLRNALVRDEELIAYVSADLQARPDTAWIWAGGEQDHAAAAAAAAAAGRAVGSTSGSSPGGANGLGTLFSEEAKMGLSKEEINEWNVNKGWTRLDEMVRGLAHPLAVPLAQAPMVPSTSSQTPTSATRPTHSLASTPTLATAPHPSYAQGPPPPVTVPGPPPPPPLHYSHHAPPPPPPPPPRGRQMPPIQPGPGPQQPPPPASWGHPPSGPTLPPPQQSRSPYIPQHVHHPQGPPPPAQPPTLPSISPAGTPRIKSEPGLPSLPPLGALGGDRDDKRPIGLGIGPASAISPSNRAAVLQSSGGGGHGAGSPTMSASRSPTSATTPTTMMPNGTSNPNGGKENANGNGAAGSKPPTVKSQSQERISIANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF08</accession>
    <name>A0AAE0JF08_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_196033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681747.1">
        <property type="nucleotide sequence ID" value="XM_062821716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF08"/>
    <dbReference type="GeneID" id="87858870"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3345134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="135" mass="15738" checksum="4C2FC13216F69D06" modified="2024-05-29" version="1">MKFLKTSRVCLVTRGRYAGKKVVIIQPVDNGSKTHPYGHAIVAGIERYPSKITRRMSKTRQEKRSKVKPFIKVINYNHLMPTRYTLELEGLKGSVSSETFKEVSQREDAKKTVKKVLEERYTSGKNRWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFE8</accession>
    <name>A0AAE0JFE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CELL division control protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_182257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681277.1">
        <property type="nucleotide sequence ID" value="XM_062821523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFE8"/>
    <dbReference type="GeneID" id="87858677"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="31"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3344664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="337" mass="38695" checksum="8985F16C06FE9BA5" modified="2024-05-29" version="1">MSTMGPATVHPETHVGFDSITSQIERKLLKRGFQFNVICVGQTGLGKSTLINTIFASHLIDSKGRLQPDETVRSTTEIQSVSHIIEENGVRLRLNIVDTPGYGDMINNDRCWDPIVKYIKDQHSAYLRKELTAQRERYIQDTRIHCCLFFIQPSGHSLKPIDIVVLKKLSDVVNVVPVIAKSDSLTLEERQAFKERIKEEFAFHNLKMYPYDNDELDEEERSLNQQIKSLIPFAVVGSEKNIIVNGKQVRGRQNRWGVINVEDENHCEFIYLRNFLLRTHLQDLIETTSQIHYETFRAKQLLALKESSAQGHGSRPISPAPDREMSRNSQRMTMNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFP5</accession>
    <name>A0AAE0JFP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_200460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681853.1">
        <property type="nucleotide sequence ID" value="XM_062821777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87858931"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="6">
        <location>
            <begin position="316"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="5">
        <location>
            <begin position="769"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="929"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="962"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1177"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
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        <location>
            <begin position="1019"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1397" mass="151802" checksum="4178B171CF44A893" modified="2024-05-29" version="1">MPSFNNNRSGESDFTEFLNCDGYQPWSNQEAPDGALAGADFNMNQACIFDSDDMSPGASLYGASQFTEASHFTAENTPFDLDQQLDENYQDGYRSPQMQFASPDVQMSPESAPATSRNSLSSSSTSMDSLTIDPSDIKPTEVTPAHTNEFMASPYDNSPSPVASMRDALSPQNPRNPQPLMPYVAPEQAQRHYSMIQPDAMVTDGPQEQASGINMATAQHMSQVIPGPVANLQMHGLPTQFIVPPSHWPAAFTYSMPHMPDGRGISFMPHGMPMNIPQMPSGFGGPPYHLDVLLMDRMRKKDGSGNANGEVEIPKMRVETQAKYRLALFPLPHGVKKLHLPTQYISKVKQMARPLPPPSPERLELHAVVVCTSAMENPDLKKKALMRARLGAQRQVKGEPKPDTDDELPGHDGGEIRICQKCIRRESKRAGRKKVKNVEEDEYWRSFESDRIIVFNAAEIQEWHEPKPEEVNAYHVEFYIRIACYGRHHNDKKKGFQVIFTIVDHEGTYIAQQLSSPIVITDDHKTRDSPQVDDEFIPDQPQNGTVNPPASNGRPTPPPPSHEIQPLKRKQPTAVPPVAVTTPNQEISQPPSPIRPITTSSKKRRVGNLTMTPVEAIAPMPPQQVSNAAAVAKPASSASSAFVPPVQRHFSRPSDASQQQFNPPPLATGAATMSYTGGSPPSTDNNDQAMFTLPGNQGLNFFANPTSGNPSRAQSPSHWQNTNGVNLLSPLMRSAVGSPFATAPAPAPAPVANPMPSAEAPVPVKLFKVIPHQGSVDGGFEVTVLGGGFSQGIVVMFGGRQATTTTYWGAESLVCLVPPSDTPGKVQVTFKNHQVRGQPVYFEYIDTRSDELAKSALACLAQKMGKDVNSFANDLIQNFNNESSGSSASGAPTYNHGHFENYLLNVIEAIDLDDTPNSKPKWNLPNSATGKTMLHLACSLGLRRFTAGLLARGANPDSRDNGGYTPLHMASLNGHAEIVRLLIAHGADHTLRTLSGFTAADVAKTTEVAQRLATSRLHSRSLSLGSLPSRATSTSSFTSLQQTTAAMSSLALERPVSESTEPEDSSEFTSDVEDSSEDSESTDGDDEPVLEMRRNSIASPPAADENVSERQRPLVDGLGPAAAVNAIMAQIQQLQQTAMLHFQNFPQLPFMLPPVVHYMPALPGYQTAQRLAATVVPGITGPRPEPKATQTTPPPPVSKESAGWFNRSNNNNSVPPPSYDESCGKGQSGFPDEKQASIAMAAAEAAADEKCAAMFDQAGSSSMTIEAAGATTLAVEIDEETEIDEEVEVEASPELPVMLEIGRKNAITKEQQENLRRAHSVKKKELSRDRNLYLIWIPLLLVTLFATVFNEHHSIWHFLQMALEYLFGSTQPLENQAPQTVIGQPQPLQLLQEPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFX0</accession>
    <name>A0AAE0JFX0_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_200936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681871.1">
        <property type="nucleotide sequence ID" value="XM_062821782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFX0"/>
    <dbReference type="GeneID" id="87858936"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="244" mass="26627" checksum="65CA1DEA4501C06D" modified="2024-05-29" version="1">MKLNSCGPKVQCFYVEVAWPSCRARALRGRGFADAVLKIERGAALTRVFRFPVPVHARGERGDRRRKTGRRPGHNHAEHLRRQHHMHVSAIACVSRDSGCQTRSQHRDVKTAVQPHVEVDTCIDVTEPFGPLGLSPTHPGKPPLLTGVETLLRPFQKTMLELPIVGRGRSIGMRLHPPLKTDEPACAMRSVACPRHSVLSRSSSMFFVEPSGSHGNGASRMEHATDSRASSNIPGGCGSKVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG73</accession>
    <name>A0AAE0JG73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_425776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682330.1">
        <property type="nucleotide sequence ID" value="XM_062824597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG73"/>
    <dbReference type="GeneID" id="87861751"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3345717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="525" mass="57531" checksum="50751B15370BC955" modified="2024-05-29" version="1">MATSPIPEKVKLNGHERQKTNTSTIDLQAVNRTATHDGEEILGLQDLDPALNRKIHLVNNAIDEIGWTPYHTKLFFLNGFGYAVDSLVLLLQGVIAGPAFREFGEKGYDNAMTIAGYVGMLIEALFWGLGADIIGRRFAFNVSLLLCSISVIIAGAMPNWPSLGLWIALIGFGAGGNLVLDTTVFLEYLPGSKQWVLTLMAGWWGLGQDVTGFVAWGFLVPEKWNCPSVDVCTKQNNMGWRYVMFTSGALVFIMSILRVTVIRLRETPKYLLALGEDTQVVNTFQFLASKYNRHCSLTVEKLEACGVVMGTHSKNRYSFAETVVHLRGLFSTPKISLSTALIWVSWAMMGLAYPLFYVFLPSYLASRGANLDVSTFETWRNYTLTNISSICGPLLAGWMCNIPLLGRRYTMLIGALMTAAFFFAYTSVRTGAQDVGFSCSIAFCLNIYYGTLYAYTPEVLPSAHRATGNGVAVACNRVMGILSAVIATVANTSTSAPIYICGALLVAMGVLSAFFPFEPYGRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGJ1</accession>
    <name>A0AAE0JGJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_441115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682575.1">
        <property type="nucleotide sequence ID" value="XM_062825502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGJ1"/>
    <dbReference type="GeneID" id="87862656"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="206" mass="23812" checksum="53A6181625B58945" modified="2024-05-29" version="1">MEQWKLPELRQSVGYQLQSFDSAFDHVHTPTSAPNSSGQSGANRNADASSLASLDELNKLNKLNNSLRLMRIKNRHQIIKSRLQARLDDQESKNRVLAARRDQLKQDEQLLASLKVMKYKIVATKYQERQLEKEIKSLDSAVWGYDMEGLLDELKEEEDNEEDKDKEEEDEGQSEEEEVHAIDYLEEESVVEEDSESNCSDDEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGP8</accession>
    <name>A0AAE0JGP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_547372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682630.1">
        <property type="nucleotide sequence ID" value="XM_062829513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGP8"/>
    <dbReference type="GeneID" id="87866667"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="18348" checksum="BCA208CCDBB815A5" modified="2024-05-29" version="1">MASLLPIIDDILPMILPSSISVTRKTDIIPPIPPVIGTADGKSHRVRVYSRDAVVNKLDKVCSTVLILSPNSYSTVRHYGEQDAIIYVASGSGVLLTAPKDEVEGSEPERHELGQGDFAAVPAWTEHQVLNESAEQDAHWVIIRSGGHPVEVHLKGWGRGKAEYPPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGT4</accession>
    <name>A0AAE0JGT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_589246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682286.1">
        <property type="nucleotide sequence ID" value="XM_062831024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGT4"/>
    <dbReference type="GeneID" id="87868178"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042234090" evidence="3">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3345673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="272" mass="26747" checksum="35DD4CB4F60734CC" modified="2024-05-29" version="1">MRFLPTVAALTGVALTGAALTGAAPTGAATTDAILTGAAPPTGDALTGAAPPTGDALTGAAPPTGDAPTGDALTGAAPPTGDAPTGDVLTGDCPTGAAPPTGDALTGAAPPTGDALAGAAPTGDAPTGDAPTGDAPTGDAPTGDAPTGDALTGDAPTDLPTAQLDLSKYSLSEITAAYLAYTAKAMSGIDGTPQSSTTNAGILDHRGHPTSKPDFRHPQIRILNLLHTTTLLYTTTLLHITILLHITIILNITILQFLHKLGPFQVEAQNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JH99</accession>
    <name>A0AAE0JH99_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_525761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682282.1">
        <property type="nucleotide sequence ID" value="XM_062828841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JH99"/>
    <dbReference type="GeneID" id="87865995"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042148199" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="20"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="166"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3345669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="599" mass="65417" checksum="E4F4FA46BD3467B5" modified="2024-05-29" version="1">MRRPSLALLALSSLPFGSARQPSSFSIHQDLLAHPQFEVIFSDSYISEADAFALLEAANKAPKPTPASDGAKDGSTQTDLTSEIRESATANADSDNGDDTTDGTSQLRETYELIAHPPMRYLCSIPIIAPPPALNKTATELAKAEEAREVTRAYNKGWELMRGLENECLHFISGWWSYQYCYGKSIVQYHAVPNPKGGPPLRDKNSQEYILGTSLSPSSQSQKGKQIEVPNTEQKQLSPPPNTELQAKDNQRYLVQRLDGGTICDLTGRPRTIEIQYHCNPALSGDRIGWIKEVTTCAYLMVIHTPRLCADVAFLPPKETKAHPITCRQVISSDEEALSFNQRRKNMIDSSAAAAATAQDQKQGSGSGSTEKMSYQGLTVAGIPIGARRILPSTHVLPLPRHLQQQRQEEQQGNLLEALTKAAFKADVFGHYGDNNHAGAGKGGAAAAGKGQGGQKEMKKMRISERDIDKLGLDQQTLEAIREEIRAAGLDPDRDLNDEREGGGEIVWEFYADVAGDEEDGVPEEGTERAFWYGEERSEEGEEQTEAGEGQKRRKEEGNNGEGSGSGNEEGNNGEGSGSGNEEGSKEEGSKEEYYRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHK6</accession>
    <name>A0AAE0JHK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_461455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682888.1">
        <property type="nucleotide sequence ID" value="XM_062826599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHK6"/>
    <dbReference type="GeneID" id="87863753"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="154" mass="17753" checksum="87D79CB2A3A80DAC" modified="2024-05-29" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDSDGKIERLRRECPNETCGAGVFMAAMQDRQYCGRCHLTYVFEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIJ9</accession>
    <name>A0AAE0JIJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vesicle coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_424433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683383.1">
        <property type="nucleotide sequence ID" value="XM_062824511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIJ9"/>
    <dbReference type="GeneID" id="87861665"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="2">
        <location>
            <begin position="242"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="502" mass="52853" checksum="D5698990F1849CFA" modified="2024-05-29" version="1">MLTQTPRLQLCLAHYCDLHGPTPLMVTEGVPVPCRTCYEEGLQHDHSHVTDQPAPSATAANASAHAVAAAAEALRRMDLAGGGALRSSSAPVSEEQAQNYRASLRRVSQTVGTSSAVETPPQSPQIPPGPPLSQQEKRRSDSGFRRTYDDYVTRRAGPCDNCALTLPKRQESSKDANPEPRPEQGPTLRTRAPFARVLSGGMDEPSTPTSQTSSSIPSEDESMTKSRPSHRRAGTTASLASRSSSSSAQGVTAHTHYLDYTSTHEPVAASSFSIVRASCLRTLSLETLPRPPATGYPSSGANPAITPSASPSTPAFVTTHSVGAAASGGPIFFGDPSAGYTTAYIFRIPDVHARGHKRVYAFLALSTHRERLAMKTFGFVAAAFRDMATWIQTLAEQEAERSLQESSANSPVMPGGPGYGSLHSEPAAPASHIPTAGGPGGGSSFLMGGGGLSRRMGSGFSASGVALKQRGLAELVGLPDFFIELHARFVKLLLELRVVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIR3</accession>
    <name>A0AAE0JIR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Aspartic proteinase, pepstatin-sensitive</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_463061</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683396.1">
        <property type="nucleotide sequence ID" value="XM_062826673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIR3"/>
    <dbReference type="GeneID" id="87863827"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042140215" evidence="13">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="85"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="116"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3348314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="396" mass="42819" checksum="22FB6A553A889D2C" modified="2024-05-29" version="1">MKGALLTAAMLLGSAQAGVHTMKLKKVPLAEQLESVPIDVQVQHLGQKYTGLRPESHSQAMFKATDAQVTGNHPVPISNFMNAQYFSEITLGTPPQTFKVVLDTGSSNLWVPSSQCGSIACYLHNKYESSESSTYKKNGTSFEIQYGSGSLSGFVSQDRMTIGDITINDQLFAEATSEPGLAFAFGRFDGILGLGYSRIAVNGITPPFYKMVEQKLVDEPVFSFYLADQDGESEVVFGGVNNKKYTGKITKIPLRRKAYWEVDFDAIGYGDDVADLEGHGVILDTGTSLIALPSQLAEMLNAQIGAKKSWNGQFTIDCGKKSSLKEVTFTLAGYNFTLGPEDYILEASGSCLSTFMGMDMPAPVGPLAILGDAFLRKYYTIYDLGADAVGIALAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ06</accession>
    <name>A0AAE0JJ06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_508404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683618.1">
        <property type="nucleotide sequence ID" value="XM_062828219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ06"/>
    <dbReference type="GeneID" id="87865373"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="123" mass="14394" checksum="453B32585E225629" modified="2024-05-29" version="1">MRQSSDQQQSAEQSTFATTATGEFICTDPECKTKPVFKRKCDLTKHQNNHRRPRKCPIEGCTYGGAEQKDLNRHLWSYHPVYSREKNIPKEETMCDFPGCDYKGRKDNVRRHKDTVGHHREQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJQ1</accession>
    <name>A0AAE0JJQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_463541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683572.1">
        <property type="nucleotide sequence ID" value="XM_062826709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJQ1"/>
    <dbReference type="GeneID" id="87863863"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042296056" description="Ecp2 effector protein-like domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="104"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="232" mass="25617" checksum="B409F7638C2512C7" modified="2024-05-29" version="1">MHSLAQLALIGLASAAVISPVSRGTTSGISVDDNFKTRDSANSSSDLDWNQSLNFTSTTSSDGDLIAKRRTDSGTYTSITPPAKQPDFCPYDLVEQPQPLLSYDNKAPLASDCGHIVDLINDTKRRGSWTFDIADLEKGIILINYKSCAFKMVKDGEISGGKKIEQFKWGVEELKFYLGTWLQKQRHGRLGSVGSVNCWVEGERKKDEGGVRVKWMVQQQFEKSGKALVYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK39</accession>
    <name>A0AAE0JK39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_97335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684016.1">
        <property type="nucleotide sequence ID" value="XM_062831631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK39"/>
    <dbReference type="GeneID" id="87868785"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="434" mass="46626" checksum="E8B07A24D134E7AD" modified="2024-05-29" version="1">MAGGLMNSIHAPKAHQPPPASSPPPSHSHHSHDEGGSFHDGPGPKSKRHRPPRGKKQLMKYIPKPDPEPQQQSPPPPSPPAAAAAAAAPVKPPSPPRARVSPKLQPQAQPKPSVAIAPNPPPPITTTSILIRTTTTTTTSNTSPIAKSPVRVSPSAKHELIRYTKIVRRLKWKLPFLASGYALALKGRDPKHGDAVISGGVLNEGEIMFKLDFFEYYMLIERALVHLLGVFGITVSGNGIQGKGLAGSRFSGQGGGSRGGSGSRGGSPKEGSPNRAGPVAGGEGAAGNGGGNKFQHRYHAHVLEAFDSPVHPLHDILGKGEVRKQLQRAKDLRNRWKTADSEAEEKERVKLTAPLESYDVEKMLETIFQGFDAAFLIAEWHVRDKEGGLDKGAQSSLNWADDDDEDGDATMMDWAAQEADQWEFMVDAMDWEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLH5</accession>
    <name>A0AAE0JLH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_110172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684487.1">
        <property type="nucleotide sequence ID" value="XM_062820563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLH5"/>
    <dbReference type="GeneID" id="87857717"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000002">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="517"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3351192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="727" mass="81836" checksum="B4725677A9B8F562" modified="2024-05-29" version="1">MGLLALGTALDWPDAKQQAHLVRAWGIKQLLEIWNKAKGKERDIMLWGDEIEYLVVNYSKDDPKVLLSLRQADILKALADSNTLKVTGDCAPGTEANGDAGNVTLPIFHPEFGRFMLEATPGKPWGIDFKDLLTVEADMKLRRCIAKDHMLPNEHPITLTTFPRIGSPGVFTEPSYPVSGPKLRSQFVPDEIANPHIRFPTLAANIRSRRGRKVQVNVPVFRDENTPWPWKDPTVNHDLHNWPEDDDVRNGAAPNNFIHMDAMAFGMGSCCLQITFQAKNITEGRKMYDQLSPLGPILLALTAATPVYKGFLADTDVRWNQISRAVDDRTPEELGEKPLKNDRWRIPKSRYASNSTYISTDSRLRPEYMDPNLVIDPEIKQQLLDGGMDDRLATHFAHLFIRDPIVIFNEDLQELDLTKTDHFENIQSTNWQHMRFKPPPADNSIGWRVEFRPMEIQITDFENAAFSVFIVLITRAILSFDLNFYIPIVKVDENMETAHARNANLEKKFWFRKNPFPVRTTRRGGSASRSASGASTPNHGPSRPTTPPLGPVEDEYRLMSVNEVINGTAYAKATSKEVTEDAEEGEEFPGLIPLVESYLDSVNMDVATRCGLARYLDLIRKRASGELWTAAKWIREFIAKHPEYKKDSVVSEEITKDLVGAVIQIGEREKRGLGIDDLIGQVPDLEKLFGGFLKGKSPCGGGQAALEQELKDDAKVNGVKRKFNAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLI2</accession>
    <name>A0AAE0JLI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps54-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_457170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684502.1">
        <property type="nucleotide sequence ID" value="XM_062826339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLI2"/>
    <dbReference type="GeneID" id="87863493"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="827"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="778"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1158" mass="125785" checksum="73A09D28150DE573" modified="2024-05-29" version="1">MFSNQGARKSVDSLSPIPDAGRFGDFPFHGRGSRSPSRPFHPRRDSTASSIHSIGGSLDSSTGTWGDAVLESGQNAISTLLQPPIVRTGLLPHTSAPASTAHKPPTARDIPPVTLTNVPPVDNSEFTQYLTQVGALYEQLRRVQADEEEASGTHSRRGSKADATSAEDGHLRPGKRSGASRRASSSSIASISSIEAPGPARRSSSYRKAASQGPPPLSTIPVVYFDEDFHLENPRTFDVVSERSEVVRPAPGSDDRAHPNGQASAPRKALATNAILQEKLSWYMDTVEMHLIQSISTASTTFFTALGSLRELHSEAADSVERIKTLRRELGNLDEEIATRGLDIVHQRRRRENIQQLHDAVMQLREVVEGVAVCESLVDLGEVDAALDNIDALEKLIAGEEGASHNGRPGMELRDLRGTTALQGVHSDMSTLRQRIGKTYEERFITRLIRDIQRHVAHVSTQEVLMRWSSASIRARGGGGHNREPSAFPSYLTSTDSLRSELLVSLTGLHRAKFLTAAATAYRETALREIKNLIRRPLPSSNDDDNESMMSASTMTGGKQRSQQERSSVLARNLRALEPRDAEELLVKIYIGVTETLRRLDTQAKVLLDVASSLGDSDPTSGLRSPPFSPTGRRLSTAALEAQEEIHTALDLSNLLGQAVDIAQDKVVRLLKVRSEQSTRLTLEWFLRYFTLNLHFANECEAISGRSGTSLKNLVNGHIKEFVQRHGDAEKQKLAQGMESDQWASQDFTEKDTELLDRILEGSTRDAAIWAEATKVWIPPSDDENDGSAAAPALGAQANSDSGDKAAEAQANGASKSKARAAVVDSETFLLPKSAILCMNGMAQFIHLIVGIPSMTADVSSSLIAYLQLFNSRCKQLILGAGALMSAGLKNITTRHLAVASQALAFIAAIIPHVREFVRRHCGNNLVSGVMADFDKVRRDFQEHQNIIYNKLVEIMTGRAVLASRKMRAINWDAGSPAAHEYMETLAKETTTLHRNLTRQLPEGTVRMIMMLVFKNYKDTFGSTFKGVEPTTEAGKESMLRDVEYFDSRLNKLDGFEDAGQHLINIVKAKEIRKAPPRPTSLTPSHPPSRGPSRAPSPALAPGSRAGSRAGSRAGSRAGSRAGSRAPTPTPTQTLTGRSSAEIIAEVSAAAEAGGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM09</accession>
    <name>A0AAE0JM09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_417064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3354107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062824063.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87861217"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="111"/>
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        </location>
    </feature>
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            <end position="152"/>
        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="619" mass="71717" checksum="648F55D54AB9AB27" modified="2024-05-29" version="1">MDFRKYHDRDEYPYESRRTSDHDRHRQERRSDDYHHTSARMRNREGQHDYQDEFDVPASQPEKTDYVQSWLQRSQANRARPPEPIPGDKPRKISPRVHMVKQASQKKKRTRSESPEPARPRETHSPVALRFEKRSRHKTRHDKYDYKPEVDRNKRRAKSKEHRRDDSYGSLEDVQRHKRSEYQHMQRSNDHVQRTEPGPSRHRSSKAKEIEALSRRPDHRSRAAEPRPRSRKQQVEDKELEELSAFFTRRAGGERAEAEKIRHRARREQRHDTAAARHPASDVRQQRTQDSPTTSLHPSRSIASTRQPSPTSLQPNTHVSSCADDPRNILPTRPSSRSTTYFTWSISDRGPNARAPVSNDSTSERPQRSIQSSARKVVLQERKIKSPNVVLEDLKIRPTSRAKHRPRKRVVYRDAQVQTSFDAETGQNRQHAKKATPQYRDSAVMTADDNSNLKERVSMLAVESLTDMNKRPVDEQHSSDATAARQIGAQPQSQSQPQPQAWVTYSAEDRLIPQPLIAASNLPVQGGWQAYQGPSAGQEVGRYMRLLPPSRIQALMPSHRLTPLRPGILHALQLGLFIFLRRGHLVKVWKTTSTGLNKKPCRIPPTMKRWINYSPIVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN90</accession>
    <name>A0AAE0JN90_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">B0H65DRAFT_562456</name>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062830201.1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
            <begin position="192"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="276" mass="29982" checksum="2C6546A041A34583" modified="2024-05-29" version="1">MSYSGSRYRPSGRQVAAPDDSRSRHPASSHHNAPSRTSQPSGGRGHDDRARSFPADAYLGYSSDGDDDDDNYYCSSSGRAPGGSSSSHRDPGHGRSRSYGGYDDYDADESDRGYGRGPSTQSRVPQNDHHGGGRNHPSSSSSHRDQARDHRDDERYYAPSGSSSSGRHHDRDSGYGRDYGRDSGPGGPSSRHGGEDMRGGDPRASESRREIPFRYVSPFDLGFGGGSRERGGGGGRSDPFAEDWDFPSRSSGHRRSSGRDDGWFSDGESDWSDGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNB8</accession>
    <name>A0AAE0JNB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_12622</name>
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    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685808.1">
        <property type="nucleotide sequence ID" value="XM_062820746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857900"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="333"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="616"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3354430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1294" mass="144584" checksum="B1A54FDC422A4204" modified="2024-05-29" version="1">MASDLGEAMAKLHFDDDAENGDGTPSFDPIDDILFDRIPPSESRHGEATDPEAHRAELEKKYLTPSTTFSTEWLNHLQQRWDTPVDHSLLFRIAPTQTRTVTRFQRHGLEGRVTGYRNVTVPASHATAKTSTSMMRKPASKSEFVRGGAGFFPFAPGGLDGIESAAALEDQLRKDAAADEGESKKKLERVITLAEGGLLEVAPGLSRGIDMSKRKKTADAESEKQAKEVEDVLGQEPEDAPGGEGEKDEVNGVKREESEDNEDDLEDIDAILPVEFPALEPRGTLAASSARKAGREWAHMVDIRREIPNFRELVPDMAREWPFELDTFQKEAVYHLENGDSVFVAAHTSAGKTVVAEYAIALAAKHMTKAIYTSPIKALSNQKFRDFRQTFDEVGILTGDVQINPEASCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDYERGVVWEEVIIMLPEHVSLILLSATVPNTYEFASWVGRTKQKDIYVISTPKRPVPLEHYLWAGKKIHKIVDSEKKFIENGWKEANLAIQGKDKPPKAIEAPTGPARGGGNQRGRGGAQRGANQQRGGARGGGQQRGRGGPPRASHAPGHMGRTGRQGGFTSAAQDKNLWVHLVQFLKKDNLLPACIFVFSKKRCEENADALSNQDFCTAQEKSHIHMIIERSIARLKPEDRVLPQIIRLRELLSRGIAVHHGGLLPIVKEMVEILFAETLVKVLFATETFAMGLNLPTRTVVFSGYRKHDGHQFRNLLPGEYTQMAGRAGRRGLDTVGYVIIVPPGGDEAPPVTDLRQMILGEPSKLRSQFRLTYNMILNLLRVEALKIEEMIKRSFSEHATQQLLPEHEKAVKLSEADLAKIKRDSCPICDVHMDECHQAGEDFKVATEELYRALLAIPVGRKMFIPGRLIVYMKEGVRTPGILLAEGPSKAGTAANPTLHVLEIKTGRDLRNDTDLLPFTPTLAKWFTPLPPHKKNIYTKTVHIPLSDVVCLTKHITKNIVPELFGGGDGYTKAKEALHQICKSWTAPIWDEMDLSRIKSLSIHEIITRRREAEIKCTKSPAVDCDLFLKHYAMCHDQWLIKTKIEELRQSLSNQNLQLLPDYEQRIRVLKDLSFIDDASRIQLKGKVACEIHSGDELVLTELILENVLADYEPAEIAALLSAFVFQEKTDMVPNLTSNLERGQKTIIELSEKVNAVQTLHQVILSSDEGSDFASKPRFGLMEVVYEWARGMSFKNITNLTDVLEGTIVRTISRLDETCREVKNAARIIGDPELYQKMATTQELIKRDITAVASLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNP6</accession>
    <name>A0AAE0JNP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_394803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686051.1">
        <property type="nucleotide sequence ID" value="XM_062823762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNP6"/>
    <dbReference type="GeneID" id="87860916"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="63" mass="6501" checksum="C84D69B78BE60866" modified="2024-05-29" version="1" fragment="single">YLAGSFLPTALVFSPGLVPWTVEAIDGDGFPVFPGASPTALGESARDGLKDVPSTSSQRSPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNW7</accession>
    <name>A0AAE0JNW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_563014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686173.1">
        <property type="nucleotide sequence ID" value="XM_062830220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNW7"/>
    <dbReference type="GeneID" id="87867374"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="134"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="260" mass="28759" checksum="5D01EC592B916C03" modified="2024-05-29" version="1">MPKPKKAPATNGKPSQTSTPSAAPPTSAAPPSWPPFKPSLPIIDLTFDTLVDDKVVVLRNFFPKSLCRDYVSFLSTLPLITTPGKPKRGMAVRVNDRFQIEDQKFADRLWYETGLKEAVVGGGLEHLWGGEVIGLNPNIRIYRYTKGQFFDAHYDDSNKITLTLPSSDDNPSNPNRQAPAKTTWTLLLYLTSASEGCLGGETVFYPHDRQVAREAIAVAPETGMLLLHKHGNDCMLHEGREVTAGEKWIIRTDLCVGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNZ4</accession>
    <name>A0AAE0JNZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome component PUP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_33308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686414.1">
        <property type="nucleotide sequence ID" value="XM_062823531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNZ4"/>
    <dbReference type="GeneID" id="87860685"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="191" mass="21279" checksum="E6AFE559FE28781B" modified="2024-05-29" version="1">MVGKDCVAIACDLRLGLQALTVSNNFPKIFQYGDVFLGLTGLATDVSTVSDLFRYKVNMYRLREERNIAPRTFANLVSSSLYERRFGPYFVSPVVAGLDPKTGEPFICGFDSIGCIDFAKDFIVSGTATEQLFGMCESLWEPNLEPEDLFETISQALLNAVDRDALSGWGAHVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP60</accession>
    <name>A0AAE0JP60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_544442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686547.1">
        <property type="nucleotide sequence ID" value="XM_062829292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP60"/>
    <dbReference type="GeneID" id="87866446"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="66" mass="7490" checksum="0577287A4560DAFF" modified="2024-05-29" version="1">MHWQNRIAFSIIVGMVAGAFAFALTYQCFRDYQRRRTLPRGADESPPVERTGGQNMEELGRTAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP80</accession>
    <name>A0AAE0JP80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="16">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_449889</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="16"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686221.1">
        <property type="nucleotide sequence ID" value="XM_062825978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP80"/>
    <dbReference type="GeneID" id="87863132"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 15 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="92"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3354843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="343" mass="37522" checksum="AAE395DC200A3E2E" modified="2024-05-29" version="1">MSLFVASTRSAFRAVAPIKRSFQTRRSYATEPSKGGSSSTILLGAAAVGIAGAGAYFFSGSGAAKKAEASVKEVTEKLTPGEIKKAFVGGDQGWVSLKLDEVELVNHNTKRLRFRLPEDDMVSGLHVASAILTKFKPLDAEKAVLRPYTPISDESAQGYIDLLVKKYEGGPMSTHLHDMAPGQRLDIKGPLPKYPWEANKHKHIALVAGGTGIAPMYQLIRAIFNNPDDKTKVTLVFGNVSEEDVLLKHELATIENHYPQRFRAFYVLDNPPKEWTGAKGYINKDLLKTVLPEPKNEDIKVFVCGPPGMMTSISGNKKSPRDQGELSGILKELGYSADQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPM5</accession>
    <name>A0AAE0JPM5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_451020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686548.1">
        <property type="nucleotide sequence ID" value="XM_062826032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPM5"/>
    <dbReference type="GeneID" id="87863186"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="7">
        <location>
            <begin position="554"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="8">
        <location>
            <begin position="947"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="886"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1052"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120826" checksum="6F4C0CB1AF2F4074" modified="2024-05-29" version="1">MKQRFSSLDVRVVAHELSEALVSLRLANIYDLNSKILLLKFAKPDNRQQLLIESGFRCHLTDFVRTASPAPSQFVARLRKYLKTRRCTSVSQIGTDRIIEFQFSDGAFRLYLEFFASGNIILTDSDLKILALLRNVPEGEGQEPQRIGLTYTLENRQNFGGVPALTKERLRDALQSTVQKVAADQAAGKKIKKKGADELRRGLATTITELPPILVEHVFRLTSFDPATKPAEILDDDSLLDKLFDTLQQAREILDEVTDSSVSNGYIIAKPRPGFEDAEVDVDAPPAEKAKNLLYEDFQPFLPKQFEDNKAYRILPFVGYNKTVDEFFSSLEGQRLESKLSEREAAAKRKLEAARMDQAKRIEGLQEMETLNYRKAATIQANIERVQEAMDAVNGLLQEGMDWVDITKLIEKEQKQGNPVAEIIKLPMKLKENTITLLLGEGVEEEEEGDDDKEDDEFDYSDDEDDADGAETTKDKAPVKRLEVDINLTLSVWNNAREYYDQKRTAADKAQKTVQQSVIALKNAEQKIAEDLRKGLKQEKPVLQPIRKQMWFEKFTWFISSDGYLVLGGRDAQQNEMLYKRYLRKGDVYVHADVHGAASVIIKNNPKTPDAPIPPSTLAQAGNLSVCCSSAWDSKAGMGAWWVNADQVSKSAPTGEYLPVGSFMVRGRRNLLPPALLTLGFGLLFRVSDDSKSKHTRHRVYDFGEGKTRGRADSLDAESERAESPHEQKPVADEESESDDEDEDAANQKARVNPLHSQRPGQDDSVESDAAQGAEPPTEELADLEITGEGSDEDNKSPAELEPAAQNEEEEGQEEDEEDSYQPSPAAQAGTPSSSTAPQKQQPAKKAPAKRGQRGKQKKIAAKYKDQDEEDRALMEELMGVKAARQKAEAEAAAKAKAEAEAAAARERRRQQQERVKKEIAEHEEVRRLMMEEGEDMPLDESEMAMEMAPLETLLGTPLAGDEILEVVPICAPWNALNKVKYKTKLQPGNTKKGKAVKEIVERWRLAASKQGWIDESSSDPEKIWPRERDLIKGLKVEEAFNCVPVGKVTVMHSGGRAGSSSGGGSGKGGGKGGSGGKGGSGKGGKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPV8</accession>
    <name>A0AAE0JPV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H65DRAFT_42380</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686668.1">
        <property type="nucleotide sequence ID" value="XM_062824480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPV8"/>
    <dbReference type="GeneID" id="87861634"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000018">
        <property type="entry name" value="Probable geranylgeranyl-diphosphate geranylgeranyltransferase (AL-2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18916">
        <property type="entry name" value="Lycopene_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene cyclase" evidence="20">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3355290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="602" mass="69084" checksum="08C812F385A766DC" modified="2024-05-29" version="1">MYDYAFVHLKFTIPLAVLLTAIAYPVLNRIHVIQTGCLIFIAFTAALPWDAYLIEQKVWSYPPEAIVGPRLLGIPFEELFFFVIQTYITALVYILFNKPVLHALHLNNQRNPPAWMRVAKITGQLLLVALSVWGWKAAQVNQETTYLGLILVWACPFLLAIWTLAGRFILSLPWFATVLPVFLPTFYLWAVDELALHRGTWSIGSGTKLEFCLFGKLDIEEATFFLVTNMLIVSGMAVFDQYLAVIYAFPTLFPKVNRYPTPLMLVQSRLVNTAKYDLERIEGLREAVERLRLKSRSFYLANSLFSGRLRIDLILLYSFCRLADDLVDDAKSRLEVLSWTAKLNHFLDLHYGDSDATEDPKQKAKRIDAYIKEAFPPFAYQALHLLPTQILPPKPLYELIQGFEMDSQFTFHGNSDSTDLKYPIADDKDLKTYAIRVAGTVGELCIALIIHHCLPDMSDSQKRRLESASCRMGIALQYVNIARDILVDARIGRVYLPTTWLKEEGLTHKIVLDNPEGPEVIERMRRRLLDNAFELYREARPEMQRIPSEARGPMIGAVENYMEIGRVLREKKEGTVFVRKEGRATVPKQRRLRTLLRALYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQK5</accession>
    <name>A0AAE0JQK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_53678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687008.1">
        <property type="nucleotide sequence ID" value="XM_062829055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQK5"/>
    <dbReference type="GeneID" id="87866209"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="69"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="245" mass="25761" checksum="50A949A3310025BB" modified="2024-05-29" version="1">MNRFIGKVVDKFGGDDDDDKKQQSQGGQFSGQQYTGGHQQQQQYSGGGDFAHGGAYPAGGGYAYEEDDDFRGAANHAANHADEDESFFSNILNSLSSKKQQVAEEDIDEDEAVRAHKTFYSSSAFSPSSETPEATSSGMGSAAALQALKLFTSGSFSSSQSQSQSAFIGLAMSQASKLFDQQASAGKVSESTDKQSVVMKAGEMALKMYLKSQGAGGSQTSSHTQTQESSSGLGGLLNIAGKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR34</accession>
    <name>A0AAE0JR34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_61888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687263.1">
        <property type="nucleotide sequence ID" value="XM_062831170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR34"/>
    <dbReference type="GeneID" id="87868324"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="314" mass="33864" checksum="F4A1DBEFC416B03E" modified="2024-05-29" version="1">MMEYAQYQPAQNSHSNPHMQTAYSSSAGGNSITSPSSQHLPQTSPILQTQQHQPSPTQGHSMYQTQYGVPQQNMHYGMPLQAAALAATAAASGTNYPNPYMAADPNLQQSPRMSGVNSKKDARAGPRSPQQMNSIPPGQRRLSQVASPGVPNAQAMLSHASRSAVPPPMTAAQQMPPPQSPEMASGAVEESPLYVNAKQFHRILKRRVARQKLEEQLRLTNKGRKPYLHESRHNHAMRRPRGPGGRFLTADEVAQMERDKTNGDVKQDGSEQSSVTAGSKSTGGTKRKAESNSGGPNKKAKAAPESPEDDDASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR82</accession>
    <name>A0AAE0JR82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_453682</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687338.1">
        <property type="nucleotide sequence ID" value="XM_062826158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR82"/>
    <dbReference type="GeneID" id="87863312"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="117"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="216"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3355960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="315" mass="34188" checksum="E33E335F417D4530" modified="2024-05-29" version="1">MSDGSRKSGTKSTFHFVAGLGSGVLSAILLQPIDLLKTRVQQSGKHSLRAALAELRSSPKGLLPSLWRGTLPSALRTGFGSAIYFTTLNTIRENAARHLPSLAAATANQTSSSLPKLSHTGNLLAGAVARSFAGFILMPLTVLKVRYESSFYKYTSLAGAARDIARTEGARGFFAGFGATAIRDAPYAGLYVLFYEQSKRYLSDLFPQEGRMTQSRAASINFASGVFSAVICSIVSNPFDAVKTRIQLQPKKYRNMVQASRKMLGEEGVRSMMDGLALRMSRKAMSSALAWTVYEELIRRAEGAWRKGGPEEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJ79</accession>
    <name>A0AAE0MJ79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_512807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676787.1">
        <property type="nucleotide sequence ID" value="XM_062828603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJ79"/>
    <dbReference type="GeneID" id="87865757"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="138" mass="14792" checksum="84716CA480C6AC2F" modified="2024-05-29" version="1">MEVTNGSSPHSAKENLAKSNTSQSRHIAQCSDNVLQNISDVGEQQSDVPDEDIEEEHGAVGIHPSLPQDIVAVDFMSQNELVAALEVLSATDLPAEAVCINVEIVEAIVAATVTFLHHNHTQCIRIDESTGQRCTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNA6</accession>
    <name>A0AAE0MNA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_551727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678332.1">
        <property type="nucleotide sequence ID" value="XM_062829838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNA6"/>
    <dbReference type="GeneID" id="87866992"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="82" mass="8989" checksum="C073869B9BC5E2A6" modified="2024-05-29" version="1">MATAAVFAELSVCAIPVDLDPEALIMHILNNYKTHVSIYGYGYGNSYERRYIDMVSSAEANGEEVEDEAVKEQENGQTGTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNU1</accession>
    <name>A0AAE0MNU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_301226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678813.1">
        <property type="nucleotide sequence ID" value="XM_062823142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNU1"/>
    <dbReference type="GeneID" id="87860296"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3339453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="610" mass="67356" checksum="C145061995221711" modified="2024-05-29" version="1">MDPATKGTSRASSVFTSLFRMGGGSQHKYSPLDHDGEASGGVAPESQTRLLPGESTDENLDEESQLKQQKGRGLLYRLVWGDPNNIFVKLIMLLLMIPLFSYLVAASLRVLSPNSVPCDTPELGYQCDQKTTHTWGQYSPFFSVPSEISPSVPEGCRLTFAQVLSRHGARFPTPGKADDISAVLTKIKTSATWYGPDFEFIKDYNYVLGVDDLTAFGEQEMVNSGIKFYQRYASLIRDYTDPDSLPFVRASGQERVIASAENFTTGFYSALLADKNPPPSSLPLPRQEMVIISESPTANNTMHHGLCRAFEDSTTGDSAQATFIAANFPPITARLNAQGFKGVTLSDTDVLSLMDLCPFDTVAYPPSSLSQESSTRKRISPFCSLFTAQDLTVYDYLQSLGKFYGFGPGNVLGATQGVGYVNELLARLTHSPVVDNTTTNSTLDQNEETFPLTNKNRTVFADFSHDNDMMGILTALRIFEGVDREKMMDNTTIPKEYGSTGDEPGLKEREGVFKVGWAVPFAGRVYFEKMVCDGDNDGDGKIDQGEEEEQELVRILVNDRVVRLNGCEADELGRCRLDKFVESMEFARRGGDWDKCFVKGSSGRLWIWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNU3</accession>
    <name>A0AAE0MNU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn-dependent exopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_552251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678887.1">
        <property type="nucleotide sequence ID" value="XM_062829876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNU3"/>
    <dbReference type="GeneID" id="87867030"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000006">
        <property type="entry name" value="Glutamate carboxypeptidase Tre2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000029">
        <property type="entry name" value="Glutamate carboxypeptidase Tre2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="351"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="539"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="797"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3339527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="103593" checksum="95221E91772D507F" modified="2024-05-29" version="1">MAPDKSQFRYEPAPPIPTYDEAIASGAGSHTVFEAPHSPLDATDHTEGHSLLGGTASSSSNNDRTRPPQGYRPPTVETDDEGEPWGSSDDDSDSEADHVRREMQEMEIDDSSHRSQSIWGKRIGRFSLPRWKWGWRLPQISLPRFRRHDANASLESATTPAANDDTNNSNNEEQPSAGSRFAFPTFGSTALFLMVARLLALFLLLGFVYLIFVSDVFGNMSRRLGSGMFNPNDIREYLESNISSNQIKDNLQHFTSYSHLAGTEGDYALMEDIELLFRKYGLEDVSRDTYHVYLNYPKADGRAVEIMDDKANNGKGKAIWSAKLEENDRATGLAGHQTWAFHGHSKTGEVRGRLIYANYGSREDFQRIKDLGIQTTGAIALVRYYGPHADRALKVKAAELAGFAGCLIYSDPLDDGFKKGDTAPKGPFMPADGVQRGSVSLMSWVVGDVLTPGWGSKEKMPRMKKEQTKGLVKIPSLPLAWRDAKVLLQHLKGKGHRVPEDWVGGVPDVDEWWTGDHESSPIVRLMNDQDENEKQAIWNVYGSILGIEQEEKKVIIGNHRDAWTLGAADPHSGTAIMLELARVFGELLKMGWRPLRTIQFMSWDAEEYNLIGSTEFVEQNDDMLRKDALAYINLDTAVTGNTLHVAGSPVFKGLLMQILEIVRDPYENATLKELWERRNANDLEGLGAGSDYVAFQDIVGTSSIDLHFDGKGHPYHSSYDTFEWMEQVGDPDFVHHTMLGQVVALLLYELVDRPVLPFDMPHYAEKIRDWTGEIVRWVEDQAKNAKKDAMPKELAASLDSMIKASNEVMDAVRRFVAWEHEWQSSVIATGGWEPSGWGRRRCEFNSKMAWFETDLLDPQGIPNRTQFKHVLFGPQLWSGYDEAYFPSIRDTVDSGDWGLANRTIAKVADIIKRAAANLAEGTLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNV5</accession>
    <name>A0AAE0MNV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_308968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677420.1">
        <property type="nucleotide sequence ID" value="XM_062823260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNV5"/>
    <dbReference type="GeneID" id="87860414"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3337969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24928" checksum="06D9D5A06877620B" modified="2024-05-29" version="1">MELRSALQSVCRTTVAAASASARSSLAGRHAFSTSARAQLQPPPNPYVSGKSRIETLRAALSNRKPAAAAAGGPGTTSSSSALPPRPPTANDNPWTIVDAINKDSSASSSGGALHSSSKPSPMQTWNETDFETRHMAPQQELNIRLRPSTGRTFYVSGHQDFAGAMKQLHRAVQQNRVKKDVRLQRFHERPALKRKRNLRERWRTRFKEGFKAAVNRTFELKNQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPB8</accession>
    <name>A0AAE0MPB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytosolic Fe-S cluster assembly factor NBP35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">B0H65DRAFT_324010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPB8"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3338464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="346" mass="36577" checksum="6D0F47DCDF0A57D3" modified="2024-05-29" version="1">MAPSLEAEPDSVASVLANPLAQKPQLVAPEPEHCPGPESQQAGTADSCAGCPNQAICATAPKGPDPDIPLITARLSGVKHKILILSGKGGVGKSTFTSLLAHAFATNSEQTVGVMDTDICGPSIPKMLGVEGETIHVSSAGWSPAWAMDNLAVMSIQFMLPNRDDAIIWRGPKKNGLIKQFLKDVEWGDLDFLLVDTPPGTSDEHLSVNTYLKESGIDGAVMVTTPQEVSLLDVRKEIDFCRKAGIRVLGLVENMSGFVCPKCTHESEIFKATTGGGRKLAEEMGIAFLGSVPLDPRIGMACDYGESFFDSFPDSPACRALKGVVKGLATEMGLDPAVVMPEEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPD5</accession>
    <name>A0AAE0MPD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_510268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678996.1">
        <property type="nucleotide sequence ID" value="XM_062828383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPD5"/>
    <dbReference type="GeneID" id="87865537"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3340054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="267" mass="29178" checksum="33B4AEAE7C0C2FB7" modified="2024-05-29" version="1">MSHRKNKAVGLAAFDRSRLTSAQYATHGSALRSSQASALETQLSVFRSLLQQFAATHAKDIKSNPTFRAQFARMCTAIGVDPLLASSGHGDSKGKGDSMWAQLLGRTVNDFYFELAVRVVEVCGETRGENGGLIEVGMVRERVVRGRVEGMGVQGVTEDDILRAVGTLKPLGSAYSVIKVGSKQYIRSVPKELNTDQSAVLEAAQVLGYVSVSMLMDNLRWTRARAQTALEDLVGEGMLWVDKQGIEWEYWSPGFMLEGDLPLEGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ03</accession>
    <name>A0AAE0MQ03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_267777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679641.1">
        <property type="nucleotide sequence ID" value="XM_062822707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ03"/>
    <dbReference type="GeneID" id="87859861"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000006">
        <property type="entry name" value="NOL1/NOP2/Sun domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="255"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3340699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="721" mass="78291" checksum="F68EF9C528260FF6" modified="2024-05-29" version="1">MSLYHETAAILTAAGPTATHGGSLKSRIFKDKSLKSPPAQVYALALETSKWSAILKEVVEASDLLKHERKLTPALSLLLTHDLLLSKSGIALPATHGLRVSIERHKARLNSEFVRARIRRRCATLDALRTQVEIEARGGCPVHPRWIRVNTLKSTVEEQLATTFKGWEVVESVAEVIKAADAFDSQQGQGKRGKKVIHIDGHIPNLIAACPGVADFTKTEAYKAGKIILQDKASCFPAYLLDPRPERDGDVMDTCAAPGNKTTHLAAIVASRVEDGKAVVFDGSTSKKGKKGGGKGTTTTTIFAFEKDPHRAKTLQKMVKTAGSDSFTVVNAGKDFLKVNPLDAKYRTVGALLLDPSCSGSGIVGRDDAPTLHLPSAPSSSSTPSSVPSTKANPKGKQNNNKRKSPPTSSSTEAKEPPTKVLIDDDGVAIPISSQADLEARIASLASFQLTLLQHAMSFPAAKRITYSTCSIHAGENEHVVLRALASDVAKRRGWRVLKREEQVEGMRRWDVRGEQGAMDLEGVTEGEGVKEKMDEKEKEEVRDAVIRAYYRDDGMGVMGFFVAGFVRDGTVDDPIYTNGTGTGAAQPEDDEEEKEDPEGPFVRDEQGRIVRDVNGIPTLKSTGKKAVDLKELQGEDESSVEYRVEGQEEGAGKEEPYQRDEEGQIVRDEEGLPVLKEGRRWKVVKGGKGQKEEEVSGEGESESKEESSEEDDGEWGGFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQD3</accession>
    <name>A0AAE0MQD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_247445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678995.1">
        <property type="nucleotide sequence ID" value="XM_062822421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQD3"/>
    <dbReference type="GeneID" id="87859575"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3340053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33674" checksum="0DE541FD4D12DBA6" modified="2024-05-29" version="1">MSVKDHHSTVGAIAEAVAEAAHGDLPGTKGHHPISAVIGTALTGGRQNAGTKGYLAAYLKQLETNPLRTKMLTAGTLAGSQELLASWLAKDRNKNGNYFTARVPKMATYGALVSAPLGHFLIWILQKMFQNRKSLRAKILQILVSNLIVAPIQNSVYLVAMAIIAGAKTWKQVQATVRVGFWKVMKVSWLSSPLCLAFAQKFLPEAAWMPFFNLVSFFIGTYINYITKKKRLAALRRKHFGDGAHGDHRHGRERERDRERERHSSPPHGHGPSHGGRPINPTLGSHHGGGPVPPPQDYPSLGQNPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQH0</accession>
    <name>A0AAE0MQH0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Single-strand DNA deaminase toxin A-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_468032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
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        <property type="nucleotide sequence ID" value="XM_062822347.1"/>
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    <dbReference type="GeneID" id="87859501"/>
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        <property type="entry name" value="Spherulin4"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAUEPP010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062826729.1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAK3344588.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3 10">Ubiquitin-like protein ATG12</fullName>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680869.1">
        <property type="nucleotide sequence ID" value="XM_062822299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRI7"/>
    <dbReference type="GeneID" id="87859453"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000148">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3343076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="153" mass="16595" checksum="648DBD1F5A6B30D0" modified="2024-05-29" version="1">MASPQQPPFGSNTASPSNNSPTASPLLEGRDSPNLPLTMTASTVLMTLPRDATAALAEAGTFDQEKVVIRFKPVGSAPALRREQVKVVSTHKFETVVAYLRKTLKVQETDSVFLYVNSVFAPALDEVVGNLWRCFKDSTNQLNVSYSMTPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRL1</accession>
    <name>A0AAE0MRL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cutinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_241461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680944.1">
        <property type="nucleotide sequence ID" value="XM_062822328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRL1"/>
    <dbReference type="GeneID" id="87859482"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042037315" evidence="5">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3343151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="299" mass="30416" checksum="8075925ACB6E9812" modified="2024-05-29" version="1">MWPSPKAAYLLLLARSALVGASPIELEERQSCPSIHVFGARETTVSPGFGTAGVVVNLILQAYPGATSEAITYPACGGQSSCGGIQYGDSARQGTNAVATAVNNLNARCPNTQIVLVGYSQGGQIMDNAVCGGPDTGSGITSSTPGINASALNQVKAVIMMGNPRYRAGLSYNVGTCTAYGFASRPAGYTCASASKLQNYCDSPDPYCCTGSDQATHQGYGTKYGQQALAFVKSKLSSSGGGGGSTPTNPTNPSTPTTPSTGNCAAKWGQCGGQGWTGATCCQSGSTCQAANQWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRR5</accession>
    <name>A0AAE0MRR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_444042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681109.1">
        <property type="nucleotide sequence ID" value="XM_062825662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRR5"/>
    <dbReference type="GeneID" id="87862816"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="447" mass="48720" checksum="121E7E49A2DD78C2" modified="2024-05-29" version="1">MDNESTPNAYLAVNHDGTSELTFTYQSACELFTDITRYSSHMRSASDLDGEYTPDYAAQYLNADFEPYSSSPSLPQSTIDSTSNDAWSQRLAPVVYHTQNCGDYGNISCVNPMDVTGTSAWNAVDNDQPQSSLTTSFHPVNYPETQAAPVQCSEPICNGTSVPSSTQTTSYPCYSPAPETAGQAPNSASTTSVDGNRYTCNDCRVSPKTKRDYERHLKTNKHKMKGNLSNGSNGSGIPGAAVASTGFHCSVEGCKYHSSTGRAITREDNLRRHVKIVHGMDLGRKSEEAFFPHPVSLGTGTYQTETVRKPQEGKPWSIHGPLMHTLKAGPNGRRKAVAMTKPLARQLALGPTLSNLLRRKRVSPGEDVAVTERGRNGTNEVQCRSVPDLDKSLTCPMKRRHQNASVFERIFEALGFERVLCDCDGDEAEATTKVSAERERGCRVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSC5</accession>
    <name>A0AAE0MSC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_147512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682442.1">
        <property type="nucleotide sequence ID" value="XM_062821026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSC5"/>
    <dbReference type="GeneID" id="87858180"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF9">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3347360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="561" mass="64479" checksum="0D83C696D373D159" modified="2024-05-29" version="1">MNTLHNTSSPPGTGTHHLNPFHLTIKDRIEHLSYPKTFALILITSWLLSSTAKWLTNGKRKKLTVPTFGYRSWFEPTLLLQTRFVKGARDLVHEAYTKMPNMPFVLKRYDADFLILPIRYLDELRLIPLSKLSNKGANVANLVPEYHGITFLLTNNLHVEVLRKKLTPELWKFIDLASSELSHGWDISLPLSELSTNGNDWVKIDFEHTVRDLVARMTAKVFLGSPACRDETWLGISVDFSIDLFTASFTMKMFPPWMYPVVAPLIPARRRVLRQLKAAQLIVGEQMRKHDSLKEKRAQAERGEVALTEEEAQDTLLDWMLDHGKGDEVKVEEMSARQCVLTLASIHTTASQAANMMFDLCEHPQWWGVLREEVDEIAKELGPPGLAGGKDGGVSVKEWCVRLEKLDSFFQETQRREPPIILGPQRLAQQDLTLKDGTYIPRGTRVAFPMLEHQMDAQTYQNPHEFDPMRFYRKRHESPEQMHLHMAGQTHPNVLGFGYGNQACPGRQFAVAEIKLIMARMLYEFEFKFANEKKGRPKTGYINEMAMTDWNARLLMRKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSI1</accession>
    <name>A0AAE0MSI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_507712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682758.1">
        <property type="nucleotide sequence ID" value="XM_062828162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSI1"/>
    <dbReference type="GeneID" id="87865316"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="854"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="861"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="897" mass="104088" checksum="8CF36D07A304B638" modified="2024-05-29" version="1">MDQQPAPRYDQYVDPLPPTDAWASFLSARYSQRKTLYEGFSATEKELVRKELRRIRYLREYFETQRLYPKPNSAPLVVLLDDSRRRWKQQAIQKCKGELAKCDNELAQPDCYRKPLLQRNRSLLLQVQQWSTQPAQDQQREELDPESYIDGLGAPDDSIDDNPCESNYGYNGWVIMYEKGQGGVTLDHPLCHGQYPHQKISVQKLLYDTVNTPLKRSEDKNQLRYFHLQANNMKWVEDAIARYYGEASGLDRQRSTILRERGMSKPTNRLSNTEKLLKRELWHGQERGGIGTHLPPHARQIRPRCAIVPSAPRAPRTHPTLGSPMSSTTNTNDVVLFMPYLHWEIEKRLTRMTNVIRKTRQQKEETHYMERQNKRRGTWGSVVDKVISARVRRQDSMPDDTFISDKIMDDAPSWRPSSRLGTYLWHAAKLFQLIDEAADWRLINDHLYGESSLHPRRTLEQYSSWTAEDTTKRDRQQVVYRGTWMKNDLESIPRVVMVDQLWMWILDENTIITAFPRRWGRNKPDPSAVHRAIRDYMASVDERQINSIYDLALIIIDECSKVIFDRTKPDLRPEVVDIFGSAISKIAEKKTESYERFGRDVKRMNTEDPLQTSEELLRKSLNIKYEWSVLMEAQNVIDQLQIMQEIFTQQITIMTDFEKVLRGLSSGHPPFQLDGLPSTLERAGSLIADMKSNRDELADLEKRQAKTRTQIRELLDMKQQQSGIIEAKAGIRRADESVLQGRSIVVFTVVTIFFLPLSFFATMFGMNARELNDGHMTIGNQLLLMLFPSLGITILSLALAFSTRARNLIFGGWRSFMGGLRKPVASTQQLTEASAQTLRNFMLEKLRERDVQYSESSQELPIHEHREAATEKRPGMWASGRFSSGSLSHLWTRRRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MST5</accession>
    <name>A0AAE0MST5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_150167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682581.1">
        <property type="nucleotide sequence ID" value="XM_062821070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MST5"/>
    <dbReference type="GeneID" id="87858224"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="231" mass="25598" checksum="D015A3FCADA27DC9" modified="2024-05-29" version="1">MAKCFSNPTFRGNGSLTRDKQGASAQATAITAVAQSSTLDDIGIAMFTDASWPPPFLRLPMEIKLMVYRNAWTVDPGEDKYLRACYQHGTMYKYHLLHTYLKNQRNPTPPTTPLDGRSTQPKLTLHSPVESSIMSAERTPPTEKELHARMIEALITAQHEVGPTWQRQPSFIRTDKPKGKNADILHWVPSARKSGGTPTRSTFPGVSSISSLGMSLTGTYRSPKIAMLRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MT13</accession>
    <name>A0AAE0MT13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_548905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681785.1">
        <property type="nucleotide sequence ID" value="XM_062829614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MT13"/>
    <dbReference type="GeneID" id="87866768"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="105" mass="11684" checksum="C18D13994816509B" modified="2024-05-29" version="1">MCTKHFIDSYCTSCDELVQGRSTESPCKPKYRGEHLGHCAGGIETKTVTEAVVCKNCERKQRRMEKKKKDKDKGKGKEKKQKCGCGSAAVELASVNEEEQPLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTH8</accession>
    <name>A0AAE0MTH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_408854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682235.1">
        <property type="nucleotide sequence ID" value="XM_062823823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTH8"/>
    <dbReference type="GeneID" id="87860977"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="259" mass="28287" checksum="DB59BDF7413470C9" modified="2024-05-29" version="1" fragment="single">QHRQATGVVPGPLMAVFPGAHMQGMYAVPVMIPAQPLTQATLNYTWANPYTRGMEPQPTEMLQPLWHYPGNTMYQPHLLLDQLQPSCPVDNGGSGSKLVHSDGHVQVKVPGHLMAKNMSQNAERNNQDIPSDLEPFPACGRDFAKTLSKVMTKTSDRLMALLEAELDRLDKLDAASEASGAVQDVNIKPGIKSEGNSGQNDELDSPGTESDKADEEPPILNEVGSRPQTSDEPKKFHRVTMTDEQQERNTVAGRPLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTV4</accession>
    <name>A0AAE0MTV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_587503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682625.1">
        <property type="nucleotide sequence ID" value="XM_062830980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTV4"/>
    <dbReference type="GeneID" id="87868134"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="62"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
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        <location>
            <begin position="556"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3347543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="859" mass="92271" checksum="EA4AD0FA8F40C5C7" modified="2024-05-29" version="1">MTTEKKRKLPPRAAARSEQAAKRRQTDTPPTSRKSSTPAPAPQKEPEPEPVVEEPPKQTLPSSIAAGKPLPTVEEPQPDDLSTKDYQTLQESGVLHESFVRSRNQWMSEQIFEKYWTKPIKKRGAVIEEPNNPPKDSMVKLGQVTITVEPHVFEATMFAVKDPNPPPPKPPTDKRPILEYGPPNGVMPPPPTPKPKSVAVSTSSTPTPAASDAKKPTTTETDPKATSQTTPQTEAKPQTPGKLTVHPTPQTQPTKPPPAQTAPSPAAPVPPTLAKPAGTPRGIESLLSPSPSLAAPQAAPRAPTTAPVVGAQPPRPVPVPATVPPNAANPATPSIPSGVPPRPATGAPAAPAAPATPRPAANGAAPAKPAAGADPIILMLAEKAGEDPQLRDLMKRVAQGEASKQELERFQGIIDTITSENKRKSNIPAPPAADKLFVDGKTVQYFADEVAAILDIVLASNPKQKSSTLQPPKDSDALLVSLVKIALDDEKTKEMVRRIAHNKPQPTDATDLKAILDLAQSNIVTKKNQQQRRQSTASAAGSSKQTNDASNGTDGGAATTTQTNAAEEKKTEKAEKATKEKGEKADKSSAQQALRSKGLPPPPKQPDYSAIVFEFAGGNGDRYLFPKFSVLDYQTIPSTSASGTQGQQQQQQQQQQQVVASFLIIRRGSKAEYPMADPELDYYQPITIRLFTAAPSGKHLLDNLARVVAPEEEVKRYMDDIMDNMQRSEYVLLAMRLPRPTETPENGEGESGDKAPDGAQTGPAKGQNAKEKEKEKDKEVVMIDAPSRAEEAAAAEPKAPKAARTGGVLWTTANKQIPKPEIRELPPRRNARIMLETTEDEQYQSFIQTVTRKDKEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTX2</accession>
    <name>A0AAE0MTX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_546036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684258.1">
        <property type="nucleotide sequence ID" value="XM_062829422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTX2"/>
    <dbReference type="GeneID" id="87866576"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="495"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="1186"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="958"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1079"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="975"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3350963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1254" mass="137667" checksum="C2E063381D5C2016" modified="2024-05-29" version="1">MDHEHQNKRHKLGVVSGVYIPVCLNILSILMFLRFGSILGQIGLLGMLGLLFTAYSVDFVTTLSLSAIASNGEVKGGGAYYLISRSLGPEFGGSIGILFYLAQVLNTALNVVGLIDCLRLNLGPVMPQGYWWTYLFETGALLVCTLLCLAGSAMFAKASNALLAIMVISILSIPVSAIFLPSFNDPVSGIEFTGVSLTTLRSNLWPHFAGDEFNGAGTFRDLFGILFPATSGIFAGASMSGDLRNPSKDIPRGTLWAMLSTLISYVLVIISLASSTTHGTFLRNTNVIQETNVWPPIIFAGEFATCFFSALMGVIGSAKLMQALARDKLVPGISVFGKGTKKTDEPLLAIFLTYIVAQFAMFANLNQIATFISMGYQMTFFVMNLACFLLKIGSAPNFRPGFKFFSWQTAFAGSVLSAAAMFFIDETYATTAVSLLVTLFLLIHYLSPPKRWGDVSQNLIYHQVRKYLLRLKPEHIKFWRPQIILLINNPRKQTRLIQFCNSMKKGGLYILGHVIVTDDFSAGVAEAKLQQAAWTKYISEFSRIKAFVQLTMSPTITWGMRNLMLSAGLGGMRPNIAVIGFYNMDDLRRSRPTLRIFRKAPTSPVKGPQSTETKQPVRQRKRGDTSARLMEGFLPTDVIRTEEMMSVTDYLTILEDLALRYRLNVAVGKGFETLETPRKDGSNTKKYIDLWPIQMSAELSADGRNVLTTNFDTYTLILQLGYILDHVPAWKKVYRVRVLVFVEYESEVEEERGRVKALLEKLRIEAEVLVFWLASGDLGTYEAIIHGRFRDQETEKLVNECLVDQEWWEDLQKIRGTHEETSQPDMSSVLTTIVESTSGRPGLYNPHSEAPDPRDRRRASWAPLADLPKKPTVSQLVRLGVSMGIHTQNLAANVLDSSDTDVDGESDSDSSSSSGILDGDFNDTANVASNGGLEALEPSRVPLLGAVRRMSHGDLFDRLKKPWKDRRSRKAGGPSAQQSYGAVSQDTGPSRSNGSESRSNNRDDFLSVGMEERPSHTTRPTLSRQNSSILKSSTARKFTSSLVPETRITSDDTGPQIMFAEDQVSPGISRRSTPGVTALLSSKQPARNNIDDNGGGGPRTVSFVEPRYNDGASSSPDKSRANSPPRTGTGSGGSGDGGGDVLLNIPELLSSYKFQQQQDNDDAAEAGSSYSTQGLPLSFNDLPSRAQHLILNELMRQNSADTAVLFTTLPVPEENTCRSEEASLTYLSDVEVLCNGLPPMLLVLSNNMTVTVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUS7</accession>
    <name>A0AAE0MUS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_422258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683615.1">
        <property type="nucleotide sequence ID" value="XM_062824392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUS7"/>
    <dbReference type="GeneID" id="87861546"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="147" mass="16884" checksum="CAA9AA42E10A34EC" modified="2024-05-29" version="1">MSSQTDAFPPGCFQHPDHSTSDDPAGTTITRKDSGVGLSEPLQQEHQDIQVCGQPETCELSPDMSQALRRFSIPHKCKFVEAKRELVDKIVNTVMENTSERIMALLQEELQKRGVQFAEDDEEEEEKEKEEEEEEEEEEEEEEEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUZ0</accession>
    <name>A0AAE0MUZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Superoxide dismutase</fullName>
            <ecNumber evidence="13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_506686</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="13"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684544.1">
        <property type="nucleotide sequence ID" value="XM_062828079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUZ0"/>
    <dbReference type="GeneID" id="87865233"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="129"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3351249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="245" mass="27089" checksum="3584B4D894704857" modified="2024-05-29" version="1">MVNLGNIWQNLLASQAPLQSMTGNATTMSGLATYTLPQLPYAYNALEPYISAQIMELHHSKHHQTYVTNLNNALQAHVAAITSNDIPAQIAQQPAIKFNGGGHINHSLFWKNLAPAETPETNYSEAAPSLVAEIEKTWGSFEGFKKAFSAALLGIQGSGWGWLVKESTAEKGRLRIIITKDQDPVVGGEVPVFGVDMWEHAYYLQYLNGKAAYVENIWKVINWKTAEERFQGSREDAFADLKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVL0</accession>
    <name>A0AAE0MVL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_420547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685189.1">
        <property type="nucleotide sequence ID" value="XM_062824285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVL0"/>
    <dbReference type="GeneID" id="87861439"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="269" mass="30150" checksum="E0E0ABFE0EDEF5FD" modified="2024-05-29" version="1">MYNGPLRLSRLIAATCVRSELDEVAESIHFHEQEKAFAVNIKYTYSEATRDVTGSIQHSGAWIDVRHILNAATSDTSSTPRLPSARLQLAHSDVRRWQLALGYGRLHSVANGLLVDRVRNLPLLTSVCTDCGDRHITFYADFGLFGLVYGGLHCVAWKAPFVSDLERVLWRVSSVAIACTTFLLVFLSVWTKFPPFWLKPAKTLDLIVEVYEALNLFYGGKIMRVLDRLAGINRWGGQGQTRKAAPKIHFKRRSGSGRWKDGADLSFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVN8</accession>
    <name>A0AAE0MVN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UreF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_420554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684515.1">
        <property type="nucleotide sequence ID" value="XM_062824286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVN8"/>
    <dbReference type="GeneID" id="87861440"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="350" mass="37001" checksum="55DF99028853AE07" modified="2024-05-29" version="1">MSQSQHGRAISDEAQAIENEIADLERRLAEAKLKQRQAQQQRNSTQESEPNVISFPSPSQTILHSPANHFLLLLSDSALPLGSFAFSSGLESYLAHNKPSSFSPSPSSSKPPRTKPPPPSFTSFLPLSLSSYASTTLPYVLAAHRDPARLASLDDTLDATIVCTVGRRASVAQGRALLSIWERSLSASLPPSSSASAGAAAAAAAILKPFSALLRSAGAAAPTSSSSSVNSSTSTSTGSSSGWNDPPPVSAHLPPLFGAICALVGLSLEQTAYVYLLSHVKALVSAAVRAGMFGPYQAQKTLARRQVQEIIAAVVEREWERGVEEAGQSVPVMDLWVGRHEVLYSRIFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVZ4</accession>
    <name>A0AAE0MVZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_506938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684845.1">
        <property type="nucleotide sequence ID" value="XM_062828104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVZ4"/>
    <dbReference type="GeneID" id="87865258"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="4">
        <location>
            <begin position="251"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Small acidic protein-like" evidence="5">
        <location>
            <begin position="582"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3351550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="652" mass="73970" checksum="E646A1F5687A36EA" modified="2024-05-29" version="1">MADRHARNPPRGGAKDYNDRDRHGRDNRDRDRERDRDHDRSRGRRGGRGGRDGRDRDSRRYRSRSRDRHDRDRDRDRRRSRSPIRERDGHDRRDDRVRDGGRGGRRDGPRDSRRDRGDADKDGMSKPDRGTFGNRSHSLRRGSSPPREPEPHAKSPRSPSQTAAHDDHRLSIRSKSENAPAAAAPVPVSFKVKGHDQRRSDITHAEEQRQSSREQTEEHEEEHMSRGRFDADPMDEDEEDDVVVEDDGLGDMASMMGFGGFGTTKNQKVKGNNVGAVRKEKKTEYRQYMNRVGGFNRPLSPSRFYNQTLKMGASKTELKAAVPSKKDKKEKKEKKSSKKSSPETAEVAAVAASDESVAVAQSSEQKKEKKSKKSKDAKHKLDEEEEEEDKPSSKKRKSEEDKETTSTEKVEKKKEKKDKKSKSESKEDKKEKKDKKRKHDDDDDEEEKKEEPVAKVAKIVKEEEAEKKKSKKDKKSKGEKESSSSSSSEKKHKEKKEKKDKKDKKSKHDKEEEEPVVKKEKKAESKKESKKDKKDKKEKKDKKKEDETKTTEAKASTTTSAATTTNTTTTTPNPAAVLAANWNVNALDGGASRQSKMMRLLGGKKLAADGAAAVAAKKTFDVNQVSQELEQQFKAGIHQKFETGGQRRGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWC1</accession>
    <name>A0AAE0MWC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_139746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685220.1">
        <property type="nucleotide sequence ID" value="XM_062820917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWC1"/>
    <dbReference type="GeneID" id="87858071"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123737" checksum="320B1690E6BA9960" modified="2024-05-29" version="1">MKDRDKNGQSAEDEEERKRQAILEKAMMDDLGIARVEDLPLEHVDPPPRHGRHDGRGPLRLAMPQPAPGVSDMWAEAQRQGLFNDDDAIAVRELDDLGGGRIYATRQQEVRAMASRIVHGVRETHRAPMLNPELQSRIAKQYHGRGREIPPNRKINIGKDMRTSALGVLYHEAQPVRQFPPNYRPSPTPPCPLAYPEPPRLVPPNRALPSSLNRVASRSTSTAPFKEAHRATSVQSTPRTTLSQAPRHLPVNHTVAPNGSRQNSASIRRPSTPTAQGPASQQLRTVGNENIVPFSGNESPPLSPELSNVLFRCEVDFPNPTRPPNRSSVPSMLYLSAARRPHMGVFTLTCEGKQVCQCPVSQYYHHSIDTRSRELVIMFRSPGGHIICHTVNFKAYMAADDFHQTLKRLRAGEYLDQVNESSRQVLEATIQEATQSTVNVPSTPANQNPVPQARAEQSIAPDLDTVLRQPIGPNVNTAYRAENQETLIGTLIDLDTFDNVPSTVQPQYARSEAAELLSTLDPIEYELEHVDDDLQLQQAQTEATELLSTLDPIDYELGHVDNNLRPTSPSQQSQSEAAEQNYGLHVIKQEFVDRYRLLLQNLIKVLGDMPKNKTRRGASQMIEGLQMCVTDQAMDDECGLDESTKRELLKEVWGNWGFQPSGAEDSAQDIQSAPNPPPNRPETPRPPLETARATPREASRPPPPGVTTQTRRQVYQRPFLVSLYDNRLQPPHWLNELAFMPAFSRRNQPPSTCQSLEATLSATSRATRPATPLPAAAFLAPDFSRSLASHAWVMATEASETVESTPTITSESTAQDVQAEAQEPQIEEPTPVVSLETTASPSHEEHVDADIRSGPELISLAVPEPTRPPSTHTNLCGLRHSLWARLGDRLETEGAFTGPRFWSSASLRELAQLDPQAPVNATPDELAEMFSARPSNQSIEHVAPRLAPGLQNDRPTSVPNHRPATPANNTSCIGGLTPQDQTPLATQRVADTPTQQPSSINAPPVQVEPPVISSSLANRGLAGSSFAISPAPESFSVPESSSVPAPPHTQQSAPPNSSANPGLAGSRWASSPTPESYSGTNSPVVQAQPPAPVVEAPSPAPAPRPINRGLAGSRFASGKVLSSSGSFTGCFSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX96</accession>
    <name>A0AAE0MX96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_56730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687111.1">
        <property type="nucleotide sequence ID" value="XM_062830362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX96"/>
    <dbReference type="SMR" id="A0AAE0MX96"/>
    <dbReference type="GeneID" id="87867516"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="85" mass="9376" checksum="B2A7B7F5FEF5DBBC" modified="2024-05-29" version="1">MAPAQPELKKYLDKRLFVQLNGSRKVIGVLRGYDVFLNIVLDDAVEEKDGGEKVKLGMVTIRGNSVVMMEALERIGGDERGGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZX2</accession>
    <name>A0AAE0IZX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sorting nexin mvp1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_566242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676470.1">
        <property type="nucleotide sequence ID" value="XM_062830315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZX2"/>
    <dbReference type="GeneID" id="87867469"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000037">
        <property type="entry name" value="Sorting nexin mvp-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000072">
        <property type="entry name" value="Sorting nexin MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="398"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3334304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="779" mass="85054" checksum="2406BB59360B2D8D" modified="2024-05-29" version="1">MSLFGSSPPDDSAALNSAKIANSSRSTLFDNEAPTTRSGSALFADDDDDSPWDMPTPRKQRSRADLIRNLLPSGDVPESYIETFDAVARTENSGSTNGRITAGGVARTLAAAKLGADDQARIMGIIAPTGAGGSGGDGANGEEANSSAAGLDLGRNEFNVLLALIGLVQEGEVASLDGVDERRRKLPQPKLQGLVENVQPVLPDLSELAAKPPQRPVTPPKAPTPSPPKQQQQQHQPRTLRKVSMEYPEDPWNAPDLHKGHNHGPLEHSTGHNGAADVPRSIGPDLNGNGAVSYSTSPEVTTTSAALPGRTTSTFTTSQPPSGPSSIHNVAESIQESNGAWNYFPGNSSVGGFSEPADNAITSPFGGNGGPGQSVGGPVGGSNPNRSIGHVRSGSNVEENILVTLMPEKEGMFMFQHHNYEVSSIRRGSKVVRRYSDFVWLLDCLHKRYPFRVLPLLPPKRVAQTVNGNHLSNDGAFIEKRRRGLARFLNALVRHPVLGQEQLVIMFLTVPTELSVWRKQATISVQDEFTGRTLPPGLEDSLPPTLEELFARARAGVRRSAELYISTCTIMDRLVKRSEGVAADHARMALSLISLTEASADTYATDNNDVPLLNDGLQAMGRHLRTAQTLMEDEAKAWEEGVLEDLKRQRDALVSLRDLFDRRERLDKDNIPFLQRRIETNEAKLQALNAKPEGMVKPGEKERVVEAIIKDKESIVTQHNRSVFVKECIRDELRFFQGTQYNVSRLTQDWAQERVKYSEMLADNWRRLLDDLEGMPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J006</accession>
    <name>A0AAE0J006_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_512894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676515.1">
        <property type="nucleotide sequence ID" value="XM_062828617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J006"/>
    <dbReference type="GeneID" id="87865771"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="126" mass="13578" checksum="3A8E2BFDA2D4D56B" modified="2024-05-29" version="1">MSTELLKTPPSSPNPGGGQGESKRAIDEVIDTPEALRRLAKRVKGILDRMNEKSNVFNSSGDNSDDPFGIDNTRQNGNMEVSAEPLVFDMSDFGCHEHVEEAKEERVPPNGTPSKTKGVAKTAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0E2</accession>
    <name>A0AAE0J0E2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_566350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676516.1">
        <property type="nucleotide sequence ID" value="XM_062830321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0E2"/>
    <dbReference type="GeneID" id="87867475"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="372" mass="40186" checksum="B83D168C31E703BA" modified="2024-05-29" version="1">MAHENFESSPPKSASSVSQEAHESRGPTRPKPAQKAEDQRRGRGDAEGSSNGDYISDDKKSPTPTNEYNSPEPQQPSRSANILPSIGVSHHQGHSEGNVPPLEGMNDTTVDTIERGPIRTSSACPELTTLERHTSSTSSTQRSRESSVEDDINNSLLPHSASSPSPSPIQPQDSSPSPSLLLAELPYLSPTPASSATASSTPPASIWVNFSPSSASGSSSYTSISEGDSEDEDWDDEMFNLWNDALEQNPGPHVDVLGLVLEAVVNPHWQGPAAAVQEEVEATFVDDGEGEDSDGDDHDSGEHTESGSDSESSPGTPSQQEFQSYIWSEPRDQEPEDTYYTSDDEVDNSDDYDDPEWAFEEQHSLEAQCRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0S6</accession>
    <name>A0AAE0J0S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_331052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676920.1">
        <property type="nucleotide sequence ID" value="XM_062823510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0S6"/>
    <dbReference type="GeneID" id="87860664"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Osh5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="45802" checksum="774DF982E9F0DEDA" modified="2024-05-29" version="1">MDSAQQNSNAAAGGGSSWGAFLKSIASFNGDLASLTAPPFILSGTSLTEFSSYWCEHPPVFAAPAKESDPAKRALLVLKWFLTTLKQQYASRSEQYGNEKKPLNPFLGELFLGKWEDEAGVTELISEQVSHHPPATAYNITNLPTGVRLEGYNAQKASFSKTINIKQIGHAVLTVPSSTSDQPDTFLITLPSLHIEGLIFGSPFIELDGASYITSSTGYTAKIDYSGKGWLSGKKNSFVASLYPTGKEKEVLYNVSGQWTKSFEIHSGAAKHNSKSTLVDSWDPEKQQHTPLTVAPIEKQHPLESRRAWSKVANAILKGDLEAVGQEKSRIEVAQREARAREKVEGRMWQRRYFSVYTDAPDRVLTQLGPAIGLAEHGDADKTGGLWRFDATKAEKERGQPQLSDEEASKIAKELLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1B4</accession>
    <name>A0AAE0J1B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_446729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677220.1">
        <property type="nucleotide sequence ID" value="XM_062825814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1B4"/>
    <dbReference type="GeneID" id="87862968"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3335054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="159" mass="17614" checksum="9F0A76BB043C0386" modified="2024-05-29" version="1">MPLFSRHAEPEPAPAPVHHEPAPKRHSLFGGSSRHRSPSPGSPTYSSASDRNRSTSRESGHGTQRKGSLLSRTFGNGTSTSHDVDPSIVQARERVMMAEAAERDADRALMAARENVRQAREHIRALELEAQEEARRAKIKQYHAKEVSKRGKQLGRHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6W8</accession>
    <name>A0AAE0J6W8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_445935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677454.1">
        <property type="nucleotide sequence ID" value="XM_062825778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6W8"/>
    <dbReference type="GeneID" id="87862932"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="124" mass="13800" checksum="E7F77042CC688B1E" modified="2024-05-29" version="1">MVDWPEWKMGNPSSPSSPSEPQAPRSKGWAGAGKLGNVERGSCGEAKLPLAWLGEARDSERGVFESRFPGMILIGLVWLHISIQKTTRRVKDWIQGTLELQHTPVQTTSGLSRGNFRKETVKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J757</accession>
    <name>A0AAE0J757_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_314958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677652.1">
        <property type="nucleotide sequence ID" value="XM_062823352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J757"/>
    <dbReference type="GeneID" id="87860506"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="148"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="338" mass="38729" checksum="43D8D02F044894CE" modified="2024-05-29" version="1">MTPRLSTLDLVAKVDAFPYADRDPEAYAQIMKSFYTFVWEDQQGQIPIGYMKLDVVDALNQAPANLKGQLGLHIDVSNRTVVLFRDAPDKTYEERTRLVGELTALWREQKAFPILKSWRNELWPVYGRNKELVFSMERAAMGLFGTTRYGVHMNAFIRRQDASSKYDFRIWVPRRSPTKSTYPSMLDNAVAGGLMTNEDPFECVIREADEEASLPEHVVRKNAKEVCTITYIYITDERAGGEAGLIYPECQWVYDLELPADGSVVPEPKDGEVESFSLRTVEEIQEQLAQGLWKPNCAVVMLDFFLRHGIYTPENEPHYDAFRDRAHRHIAFPGPHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J827</accession>
    <name>A0AAE0J827_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_551550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678134.1">
        <property type="nucleotide sequence ID" value="XM_062829817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J827"/>
    <dbReference type="GeneID" id="87866971"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="150" mass="16908" checksum="F4473A4548756F1C" modified="2024-05-29" version="1">MEFTWSYNNVTTLPPAHAGKTISQVMAENTADTFQGYITSHEHAERLEAEYTQLASAQIAVTIRQESLADIPRTNEGRAHWRERIFYAITDFSNVVNKDRVITLAPYGAVSRGTRGRTRLADTENEAGKKLLFQRGWWAHTPPSTTRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J859</accession>
    <name>A0AAE0J859_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_282088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678115.1">
        <property type="nucleotide sequence ID" value="XM_062822893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J859"/>
    <dbReference type="GeneID" id="87860047"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="52"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3338755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="380" mass="42817" checksum="E5344C10B0A74859" modified="2024-05-29" version="1">MAPSAVEAVQTAVQTTINVKNQANQQATPTQHAQHVEPLKLSGVLDQYEHFDVTPIIGREFPKANLVEWLNAPNADELIRDLAITISRRGVVFFRAQHSLTNDLQKQLILRLGALTGRPPTSGLHIHPILNSERELGGNDPEISTISSIQNRQFYRDDDNKSEELSTKKQYTAQWHSDIAFEPVPADYTSLRLVQLPKTGGDTLWASGYEIYDRISEPYQKFLEGLTATFQQPGFNKAAERNGFKIYERPRGAPENVGSELKAVHPVVRTNPVTGWKSVFPVGGHVKHVNGVTKEESERLLEWFLEVLQRNHDLQVRFRWQGENDIAIWDNRSVFHTATFDYDGFGERFGNRAVGLGERPYLDPQSTSRREALAAAGELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J894</accession>
    <name>A0AAE0J894_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_474669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678175.1">
        <property type="nucleotide sequence ID" value="XM_062827257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J894"/>
    <dbReference type="GeneID" id="87864411"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="80" mass="8764" checksum="8D858B52B77BC92A" modified="2024-05-29" version="1">MKKGTRFFPSVSLLFLAVNIPRISLPSLTAPHPFSTRTIGLLFIFYPGVYLILVAATSMASATTEVPNTYPKNYILNAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8B9</accession>
    <name>A0AAE0J8B9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_285077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678297.1">
        <property type="nucleotide sequence ID" value="XM_062822933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8B9"/>
    <dbReference type="GeneID" id="87860087"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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    </dbReference>
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        <property type="entry name" value="AminoAcid_Transporter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="64"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">B0H65DRAFT_445129</name>
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        <name type="scientific">Neurospora tetraspora</name>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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            <end position="150"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="166" mass="17770" checksum="F542A0E45CBAC5E3" modified="2024-05-29" version="1">MLEHRMSPAAGQSGAPVIMKFQCYDMGLVPDAVIATHCSGGPCNNHACVISGPYGNDYMTLLGGLSKNGSPFITLWNSAFEDFPRGILIVILVGFQGRMWRGRSSKGTNRPDPVWGNSPGAASYLAVPRPPSQQDGPLQLSSPQQGEQDEEAVWLRRGLVAVDSAI</sequence>
</entry>
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    <name>A0AAE0J965_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Ohm R.A."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678747.1">
        <property type="nucleotide sequence ID" value="XM_062827357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J965"/>
    <dbReference type="GeneID" id="87864511"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37743" checksum="82E76B3CF1D17F6A" modified="2024-05-29" version="1">MYAPETTWTRAFLAVAVVQALVASSLEAYVLIAVERCFEPEVIQVARGHTVPMFFALFIFGFVYQLFLVYDALRSSSMIQIVGLCLYNLCLLLYAIFQPWEIKDALESLASNRTWDGKPLLTPGTDAWGDSKPALVALALVVAVATAMFYSVAWKLRSEFAWLVYKAINADLSMKKRVLILQSYVALLKFDMFFLLGFLAQNMIYASANMGKPEFGLSIGAILLVLLVIWLAVVCALRENKVGTLVIIVAHFAAAGFLCYKLTNIPRALFMFRAFAAITLVMTLCTIGMAVLCLVNFGKGVKTFTESQQRQSSHNLQETDYASPSYLYGYTPRRSPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9D9</accession>
    <name>A0AAE0J9D9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_475386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678451.1">
        <property type="nucleotide sequence ID" value="XM_062827305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9D9"/>
    <dbReference type="GeneID" id="87864459"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="108992" checksum="16F9171C8F0288F4" modified="2024-05-29" version="1">MSLTSASTPTYRAGWAKASSLASGAAVVRHHHQQQQTRGFRFGRAWSSYLDPEYTQDVCHRQRKIRYKYFQTLNRRLSWEQHPLAEDAKSTIKRMSKDYWYPVEQENSARRYVDEEIAANTINNPTGIRPGQNIEDAERAPLEDLLFGDAKKQMKTKAEAPLEKSKRYRGNKNKFKSVKADSEYVIDPITNRKVLKSATFGLDSKAPPSGPYTSQFTNLSPPELDASKPIFYDGPPPEAELKLYSQVKIDDAPWNPIDPASATTLSDVLLKDTSAPDLLNALSSDHAEVSWHPNAGIAATTAVPPLGSQPQPVAYEASETFNEQEATPGELNKYGPVRASEPDGKYKHSIEPVANQAELGQYNAVRSHEPDGKYKDTPESPADQTELAKYGAVRSHEPDGMYKQASEKNVDKAELGQYGAVRGHEPDGKYKDVVEEKYDPAELAEYGAVRAHEPDGKYKEEKGVTNTQEYDPAELAEYGSVRAHEPDGMYKQEKGVTNTQEYDPAELAEYGSVRAHEPDGMYKKQKEVKNYDEYDPAELAQYDAVRAHEPDGMYKEQKAFTNTQEYDPAELAQYDAVRAHEPDGMYKKEKEYTNYSEYQDLDSYDKPFLSHEPDGKYAAEMARAEPRSEPPVLKQLREREQHANDAELEAAWTAHCEKNAVDEAKLSKELSQYGAFRSHEPDGKYAAAAQGRQTQAQAAREETPSEENPLEAFTYEDAQTTKSSAASEPQTVETTTTTTTTPTSEPTLYKILAFNPDTQSVEAAETTSSILPSSNSANTSTSPADVLPRLTNISKFLPHFARLESQGFEIAAGSGDVLVFRKVREGVTSPQSQTTVHSEPAAVAHNTRQAVAAADGSGSTATMATSGGSTINPIDMTGGLGGKRDYHVAAGRFASPTGFVNYNLPSAAASQSSAASEKVHYEEASAAAETRQQQEQKQQQKQEKGQRKRASLPKRAVMGAAWIAGGAYSVGVVREYFRTGGVDGKGPKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9R9</accession>
    <name>A0AAE0J9R9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_445462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678613.1">
        <property type="nucleotide sequence ID" value="XM_062825745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9R9"/>
    <dbReference type="GeneID" id="87862899"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="267" mass="28540" checksum="158BAA91E0AFD889" modified="2024-05-29" version="1">MEVKLRLKLGGRDGLDRASRQCLGESEGGVFPYMLETASVAASIVHHAARTPGDGINSPTEGVAPVKSSHQASISNLAGCVSHREHHTYPSELPHLPELAAPCFNKLLGVDKYISSLGLVSILSSSAPTFIAPSNGTDVMCWDMSELLCHRNHHGLKNRSSSDIKSIGLPFWLELLSHEQNAGLAKPVLFQGSRRLTDIGCYRQQNGDPSSYAVSSSTACHQLSIAIADGLVAKGINRPFSICTPAGTTGTKSHLEDGRSDYLQQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9S4</accession>
    <name>A0AAE0J9S4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde/histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_510243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678969.1">
        <property type="nucleotide sequence ID" value="XM_062828380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9S4"/>
    <dbReference type="GeneID" id="87865534"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986:SF1">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="120"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3340027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="491" mass="52638" checksum="DE5F8AD9409BFC14" modified="2024-05-29" version="1">MTPDPQPTEAHEHSSGLSTFMEQPQLLYINGKSQPSSDGATFPVNNPMTGQHIYDCASASVDDYSLAIENAYEAYQSWSKRGPTARRMVFLKAADILDSYLHQDAGEIMSQEISAPDYWIRGEVIPTDRPGTTAFMERQPVGVVFGIAPWNAPVNLTARAVACPLICGNTVVLKPSEFSPKSQHLVVRALTAAGLPPGCLNFLPTSPERAPQVTEFAVKHPKVLRVNFTGSDRVGRIIGSWAAECVKQCILELGGKAPVIIFDDANIDAAVEAVVFGALSYSGQICMSTERVLLHRSISEKFKAKLLAKVATVKTGNHLEDSGVSLSGLFTPASARRVIDLVKSAVHGGGAKLLAGDLEITGPNKTIVRPHVLEGVKRDMDIAKKESFGPVIILSEFETDEEAVALANDSEFSLCASVFSTDVVRALDIARQVRAGACHINGPTVYVEATLPQGGTGGSSGYGRFGGMARVEAFTERKIVTLATSKLMYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9X6</accession>
    <name>A0AAE0J9X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_550550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678990.1">
        <property type="nucleotide sequence ID" value="XM_062829747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9X6"/>
    <dbReference type="GeneID" id="87866901"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="246" mass="28299" checksum="8AB878692D6E1152" modified="2024-05-29" version="1">MDSSSSDGVVQDQATGAGPGVGNVINSDAVSNAGNVADPVLPPLSPGDFTVYNRLAKQMDYFHNHFRSMWNMLYTACTRNGSSQGTAELTERQLIEEGLRLTRYLEAHHSIEETYIFPLLAKKMPQFRAAVNAHNHQHQDRRHHHQSETEEDHQEDNKEEGKEEEEEANCELIQQHRAIHTGMEQFEMYLRDCRSKKEAFSLPVLKEKMDSWGEVLLKHLDQEVEELGAERMRRFWSLEEMATFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB75</accession>
    <name>A0AAE0JB75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_472501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679408.1">
        <property type="nucleotide sequence ID" value="XM_062827148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB75"/>
    <dbReference type="GeneID" id="87864302"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="566"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="666"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="568"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="833"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="884"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3340466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122475" checksum="6C281458FD56B7BB" modified="2024-05-29" version="1">MDSTTPAFIPIRTRQPRHSENDFMNYSDSAYGSASESCNPATHDVSRVSYHVRHLDTFAQALEDSANRAFPTTASSQQRYSKVQALFLHWACDDLFVLPELEDLEKCFREDYRYDTDIFAIPTENSHLELMLKIGDMIKQHEDKKTLFIVYYGGHARIDDSRQSTWCATRNPNSPWLQWSAIQTLLERSPSDVLILLDCCAGAASATFPSGQSITETISASSWDAIAPNPGRYSFTNALIEVLQEWRHRVFSAAMLHAEILARLKHPRPVLINGKHFESRSTPVHFMMTSNHKAPSIEIGRLVPESRRSLSPYQQQSLVSSSRQDDWGMSSRSAYPSLPSMSVPMTSEPNEDEPHVMISLALEDDQRLDLNAWEQWLAGFPAIAKYVKVQGVFKSHSTLLLLSLPIMVWDLLPDDPACSFIAFIRSNNLLRESNTTKPPPESEVTARNEEEENQAMDADTESLLSEMTTNYPGDTHQTDSQARTHIQSGDFGSRQMKHPRHELGSRPAVLSYTEGQLAGSVMSPSPDPSLSNPPDSSTTSFSAISLTRTTDNVTSTPPVWPPEHVSDPTDQAQNLTREAIAHLEDCFRKDPQPSEAIIGLLSSTLNVDSNIVGLWFDQRRQHEQTTLNLQSLHRRNSTHQTSTSKEATARMILPGHLNTILSIYPNRGAILLLDLRSSTDFEKSHISSAINLRCPVSFIQHASLEMIEDTFTDVSSRHSFNGWYQSRCVVLYDRCIEFDWECPVANALLAKFRGKGWKGQCFILKGHYREFADSFDKWITDKGKSAASESSSEQLLGGGGTSSYHNDATEEEERRQRRDREYEEWLKEFDESGEGLGGRRITELGPAKREERARAVDQRQQELERELETRFPALWRKVVAMRGERERRDGAGAGAEGETLGNRRGGLDDGPSTATQTDDIGDESVSPPQSPPPPPFSPTADTDTARAANSQFQGGYDKAQLVEPLVSGLQKMREASGLGLGLMSPDPAFVADYSNSHQYDSTPYCGSAKVGSYNQGGLTDDYNDYYDAVDPISESWQGVGGGMGMASGTVSPMPPEWRDESGMSSYGGAGGTATEGERGGAKKVKKRTQLPLWERLRGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB76</accession>
    <name>A0AAE0JB76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_267144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679613.1">
        <property type="nucleotide sequence ID" value="XM_062822698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB76"/>
    <dbReference type="GeneID" id="87859852"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="183" mass="20378" checksum="344A9A94EDF6EC66" modified="2024-05-29" version="1">MHACSPVISFACLFGASCGEYRTNGRFNHLTFLPDKENRHLSPWTTSPCRTNSRGFSVRNFAFFCSKDRGDAKTPVTIEDTQKDTTCTPGFLHFSAFPCSVLISVPCPLQLFAMGFEVLERCRINRPRSLAQHQKSRTPFLSSHSPGFNEDFCGSSVSMPGFLILDKQRPLDSSTTSEHVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBK3</accession>
    <name>A0AAE0JBK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_280015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679992.1">
        <property type="nucleotide sequence ID" value="XM_062822866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860020"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3341050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1325" mass="145314" checksum="4A40514A8B1AB8A5" modified="2024-05-29" version="1">MASGIPMGGFQLGSSLNRRLSRLYNDTKKSSDFVKEPVQHAEADPEIKSLHRKLKIQKDRLVSWGLEWSDPTHSAEVYIDSSLSKAGLSEVVGSIMSTIKDILAEAEPLWNSSKQLTGESNEPYQPPKRGEKIRMVVWDKNRFEDLIRDLTTSIDTLYDLSRTRSSYAQHSSAARERLQRAVASPAEEYRPFESTRIQTPQQIDPTTLMNLRDMQAVPMTEAGNQEQGTREIVFMGKQAYAELMERMGAQISYGPLLLEYAPFDSIYSITGISPPMTRFERLSSGLQADPQRSSSSWVGLPRLLGYFEDMENSRFGLVYRFPRTFNPVTYENLTQNPLYSMCSLANLLARPDFEPKLEAKFRLAANLANTIFDMHARGITHGNLLIDNISFCNAVSTDPEISGMSQGEVDIRRPLVSSFDLFSDPQSQDEPDPFTPYRHPLDPKNSTQSPLNNNADSKTLDLYSLAMILISVGLWNTLENILPDVKNPVVSNSILDQLAIRCGTLYMKAVQTCLRAVDQEIGGQHTMDEIARHVEFKASRYLEACCILDGVSNLEERLGDDLSPAPPAVQVPSEPTASGSGSSKESKSEKVAVETPTRRKSEESTPPIAVVPVDPELEVRAKIQDSSGKEKARLYPHVPLPPDVVEQWNSVLMPEINSALKTFYRKNPESVEISLESIGESPQRTKPTVLVVCTSVSKVRAILKKKLGVLFDGTRSNLGLKVCKGQVLRSRKQVINRSMANPEDTGDVIAANPSYQPKPQNGASIGAWIGDRHLPPVSLGGLIVVDDKPYGMTVHHMLDDPDSDDVADDNTRSMAGGGLNDLAAWYAQQYLNTDESSPDSSENDDYACEFSDTDSEAYSESAITSEASDDDEHYEEEEQFTEPGDIPGIEPGCGEGFIITQPALDDVASDFYPSAEDKDQDHLDTFRVGEMYASSGIRRRKENGLVHEIDWALFEFEDDRQPTDNFIPKASNPSPGKKGKKHTRLPSIPPDQIPTILPTSIAPSHTLPGLQVQCMARSSGLQTGTILPALTSVKILGRASPSHTYQVSGTPSLGLVPNRPNRPSGSSDHSINSRRQPLPMGIPGDSGAWVVERDGGSVCGHVLAWSSRKRVAYICPMEVLVRDIAEVLEAEEIRLPGPTGAIIYQSYEDRTPGVSRQASKASTRTVGGGYGGYGGGGGQSISRQTSAASARTYVGQQDFGSVGLGRTFSRGSAFSGIGPPGYDDYPVDENTPGTGRQSSVRRLQKQVEDEYLPAYSELKQAQAVAAANLSRQGERPGNNNDNDDNDGYDEGVEDLEHDFKDLHLEAAALEGAMPFGVERWGTGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBR2</accession>
    <name>A0AAE0JBR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_215611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680067.1">
        <property type="nucleotide sequence ID" value="XM_062821984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBR2"/>
    <dbReference type="GeneID" id="87859138"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="185" mass="20350" checksum="C70109E09506B8A0" modified="2024-05-29" version="1">MTLHQFGVSLETYLMTNPTIKGVIVSAVVLHHDQILLIQRAATDGFPNMWETPGGGVDLGDETLSHALTRELLEETGLVLKDVMGLLDQLEFEGASGEGRYRKLTFLVSVEDADGQHEDPQVVLNPMEHQDFMWVSKDDLRTGFCGQREIKFAYPGQRETLFAAFRADTKTPGGTKGVNGAEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCD1</accession>
    <name>A0AAE0JCD1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_578554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679657.1">
        <property type="nucleotide sequence ID" value="XM_062830733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCD1"/>
    <dbReference type="GeneID" id="87867887"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="221"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="844" mass="90997" checksum="FA75C99D3C0CFD56" modified="2024-05-29" version="1">MPSSLPLKTRISPPLGAGPSLAEGGDHLPGNLTSALEYASKRLQRKGAKFTLLVIRKDYQLPTSPLGSPSAQSFSCGSTPSSSTSNSVASTPAKPTFAHAFKQFVRGDTGPIKERVININTDYRYGATSPTFSEASLTSASTASTVDSVFTNHRGRVGGARWPLSPGASQAPSVPLTPATPCYSITSSMAAGDNINTTCLPSAGLHATRGFGPALLQIPSSPTSSDFGIRLIHAIPLKEKEDKLLCSTLEKAAKKFNISPSSLPPPIPASTLGLPPELLHRSLAQNEVLFGPSSSSSGAAGLRLLSLDHLYTFRSALQCYTRTVNHKPSVSRSIAHRRLEDAMDELRRLVLGNGCQKLKKSCLVGAYARFMDPVSDRSLEEVGRMYGRAYGRRDHRGGRDVREKGWVDDTVEKVEGVEEGVFELMGDLGMPPAMMKKERPLPVAPVSERWVGPYYFGGVEKAVVVAEEDIDLDEITDMMDEIDLESKLEMDDIEAWYRNVQIGVGQIGVGREVRMVNVNGAQQYRQVQPPRAAAPIPTVDINIDIDNDDRTPTREVERVVIHEMQELHRTTPRLSPAPPGRSARPNMLAGLKLQTTFDPRPPKSSNKKRSPRQRLAPPSPARQSDLELTTPIRVQRTLAKMELELVIPPTKPKRGGFIYNSLSPLETKSPKSQTSSPSTVQGAQSPSSDFDSPSTVINSNPTTQSTPSSSSPSSSSEEEEEEEHTARPLDSPRTALTATRINIWLPHSSGNTLDGILHNGGNSSSSSNLASSDVDESDYSDNERLEVSPGGGRYNRFGNRLGPLTPNGYDDISPITRGEWGFLMDVGGAGGVGGLARRAGVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCJ1</accession>
    <name>A0AAE0JCJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Restriction endonuclease type II-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_215949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680096.1">
        <property type="nucleotide sequence ID" value="XM_062821990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCJ1"/>
    <dbReference type="GeneID" id="87859144"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="82"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3342303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="403" mass="43179" checksum="E58A4F11BCD3E743" modified="2024-05-29" version="1">MDDDFDDAELLQALAASEAAAARQQPQRPPAPGRGVVQPTPQRLDKPPPSNSSSSSGPRIVQPTPQPLPGGATPGSRSSGSSILVSPRQKGNPVLASIKSTAWEYSDIPSDYVLGSTTCALFLSLKYHRLHPEYIYTRIRLLQNRYLLRVLLVLVDIPNHEEPLRELSKTSLVNNVTVILCWSAQEAARYLELYKSYEHASASAIRGQQKTTYAERMVEFVTVPRSVNKTDAIALVSTFGSLRNAINAATEANGEERLSVVQGWGEKKVRSWRRAVEGSFRVRKAQGRKAGTGDSGGKGKNKVLEEAVDVGRVVGSGSGAGVGTQSRTQTQVRQKETQDRAGATGHGPEDDNLDEIEAVMASEEAGPAVASGSSSTNTPASRRREEELSGGIAAALAKLRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD52</accession>
    <name>A0AAE0JD52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_235988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680785.1">
        <property type="nucleotide sequence ID" value="XM_062822261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD52"/>
    <dbReference type="GeneID" id="87859415"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="194"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="658"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3342992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="687" mass="75646" checksum="B030FCC76DB5601A" modified="2024-05-29" version="1">MNSTPSVPGKSLSAPPNSNFSQAPPQAPSPVGFDSARRQGTGQGQGSSASQSAPRRNQGARRQHRDMRRPGAMRQQSRVNDDEDILAEMRAMRNASSRRGQTSITHLLNLNPPPRPVYDSHHSYSSRSYRRNPSYGVGSGYHSMDKARYVHANYRFVVSPCGNYTAQASDADEHLEWADILQIIASTESQQTSCPICLSEPVAPRMAKCGHIFCLPCLIRFMNTVPNDDGRSPPEKKQNRWRKCPICDDTVYLNEVRPVRFYAGQESALPRPGEDVVLRLMARNAKSTLALPKEGAAEVLHSGDDIPWHFAANVLDYARIMKGTTGYMEEQYDQEVEDITKQEKEDELMFHEDNEWTQKAIRAVHAAKEKLKELDSTQTTALATSAAAGSRSKKRDEDLDFFFYSAPPHLYLSPLDIRILKTQFGSFSEFPTTLLPRIEHISTGNAVDDVMRKRAKYLCHLPRGCLISFLECDWTDIVTPEVLETFKEETERRRERNKDKVAQEERERLQAERLEAAAIRGTRRQAGPLAEEGIIRYGNADADRPPVNMDDFIPLGAEAPSTTPPNPRAGFGTLSEMSTSPGAQRTVWGTPAIHGDEPEYMAPRNPVDDGWLKDDDVIDSLSAQDIAFQMEAMGLENGAGSSSAAAAAAAAAAASAVGGAKAGGGAKGGKKKKQKITLMSTGGRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE33</accession>
    <name>A0AAE0JE33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_245683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681113.1">
        <property type="nucleotide sequence ID" value="XM_062822393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE33"/>
    <dbReference type="GeneID" id="87859547"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3343320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="200" mass="21839" checksum="5204243E3D1F5317" modified="2024-05-29" version="1">MDFFANLHGLCPVHFPVNANAMTFLDNEVDQAQWGGLDLEQAPDQLVCLCSEYASHDDVDLDNAGESAIAEPTAQQSLPQSTPTHGVTFNSLNSQESNEASGSASADPASSSIPSPRLFTCDHCGSISAKTQRDFNRHLATARHRKNASRNGREEIQLNSSPNRGTGFRCPVASCDNTFPRKDNLWRHIDKMHGISERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE37</accession>
    <name>A0AAE0JE37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_576918</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680876.1">
        <property type="nucleotide sequence ID" value="XM_062830674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE37"/>
    <dbReference type="GeneID" id="87867828"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="15">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="506"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3343083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="603" mass="67486" checksum="2C13AB1217634F6D" modified="2024-05-29" version="1">MSTFNGLLAEFPDIRVDFFRNHPNRRPPLACFLSHVHTDHLAGLDTLRSPFVYCSAATREILLRLETVSRRINYAQGILEARQLSYKHLKNLLKPLPLDTPVELELEPGNHIQATLLDANHCPGAVMFLFEGQGKAALYTGDIRSEPWHVNAIARSPSMVQYAYGLKTLDTIYLDTSFIEDIDFPTKAQGISELLDKVSKYPPNTIFHFQAWTYGYEDVWVALSKALGSSVHVDEYKMGIYQSLLAKDPANKRDFGVLHHVSPEAPALVGFMRGNSYHPGCLTLDENVRLHSCEKGNYCKTVRENPVVQIHPVLTHLNNGEDLPELGIGGGGDDLEHDEEQDHLSQVQIQMATKFIRWLEKSAEKVELLPLESFASGSKIEIGMELLTSGADNKTALLNFLQDLINKSKSQIALDRSLLAANSRAEGTLPSIITFPYSRHSSYAELCHLVDAFKPKDVWPNTVNPREWLEQGITIEHLFGKHCSGISFRHDQLMEEIFGTREQPIQISDDSQSTASHRASSFHESSSPAPQIVDNWDGTTIAPNLNLESSFSQISVQSEASFDMRTHAFHLMLDNAMNNAGHELGLISTRDHHTNMEVELGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEC5</accession>
    <name>A0AAE0JEC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_508619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681405.1">
        <property type="nucleotide sequence ID" value="XM_062828242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEC5"/>
    <dbReference type="GeneID" id="87865396"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="65"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3344792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="464" mass="51053" checksum="C6C420BB57D17E99" modified="2024-05-29" version="1">MFNLNLNLSYQNIHFRHPSSSSSSPIPLPTLPPGISRSFIPTPHGDLEILHTSPSPSTSSQQPALFFIHGGMGSASVWLEYLTFFSAQDDPKIPCYAISMRGHGGSWYPSYLRMVYGTTKGDLAGDVVEGIKWAVGRERERLGLGHQEGNVRGASGDGKERGDVERGKEEEVEMILVGHSAGGGQAQYILSSADLLSGLGVKVKGLVLMGAMPGFGSLPVYLNWFALDPLFTLRLLLHLWHPNSPLSHPSLVRRIFFSSNQLPDSYLSRFMSFMNRYESLLWPLGMCYSFANPEKVLLQISGWGSETSIRTQTPGKRQRQERVLVIAGEQDVIMTQPIMQRLAGWRLVEGKKIDGAVVREEDETVEEEIERDDGIEVEGSGGSSKDTTGMGVRYAIVPGAGHHCQNDVGTRFHAPSAPIPNLLLLSFIASALSSDRLSTSLSYVGIKPNSETERYTYNPMRTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEF2</accession>
    <name>A0AAE0JEF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_426502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681447.1">
        <property type="nucleotide sequence ID" value="XM_062824634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEF2"/>
    <dbReference type="GeneID" id="87861788"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3344834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="339" mass="38435" checksum="ED61180721422001" modified="2024-05-29" version="1">MANSQATRYIHQNALRPSLFIYSCPTVYTTTKSRPRETRTQNMSQSKTPFLSRNYEKDHEEEDETENDSTTDVDLEDALSTTSHKSPRPHRRPSPSFLRRVLFRPCPDLILYLFALWGFLSLVFQLAQLLLPITPIFPSYHVQTTTTTTSGARPGTSSTTKDIDVYRPSTFPSPSYDLCSCGSSLREAESLHCVYDTMAAAWLPPYCRDPVLTTIFDRSGPGQGGSWSYYADKDGSVRLSPHQISLLADKPKGENVFWATREWHLAHCLFYWQKLVRMRDTNAIMERRFDGWHHARHCYGLLMRRDAPPREMLLEVDVRLSSGFEGGHEGEGEGGGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JF03</accession>
    <name>A0AAE0JF03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_465410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681684.1">
        <property type="nucleotide sequence ID" value="XM_062826805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JF03"/>
    <dbReference type="GeneID" id="87863959"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF20640">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="127"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="4">
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            <begin position="604"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
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            <begin position="881"/>
            <end position="1002"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="350"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="977"/>
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            <begin position="350"/>
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        </location>
    </feature>
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            <begin position="803"/>
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        </location>
    </feature>
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        <location>
            <begin position="824"/>
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        </location>
    </feature>
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            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
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        <location>
            <begin position="986"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20640"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3345071.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111639" checksum="7C96B440B7E382C0" modified="2024-05-29" version="1">MADRHGPIRPVGRTHALSRPRAHAGGIVGRLTYIPAQINQGTGQLRKDRARDEIPQFQQVTPFNQWSAPTKTAFPDLGSFGPSQLAKSQNNWLLKTLPEAFLGDVDTETLLIEEISNTYSRTHPAPPTTASLLATGEITDVRDPDRVRGHTVLATASGESGHILRLISLAREEWSWTDEDVKIRLHVPNHHLEGDWCQDSVPISLIKFVNDSKKYDQIRWLIVQKPTSTTVCEPELRKLPVQCSSFIQPSSSTLTQLVANPLFTITSDRSGGGSHSDVSFNPLSDNQVPQLAIIDQAGYWSVWDIVGRRGARPKAMKPVLRMCGNINLGSIPKFPGRTADDQEPHRIMWLSLKRDRSDDESRSRSSTRARPRQRLSRASLLLLGNSTTLCLFDTETRKSADQPHLLSAKKGERLLDLAPSHLDPSQAFLLTNTAISWLSVKEDGPRLRLEPLVFSPHRRDVQDPTLRLEVSPGTFIDGALACFVSIRSSRNGEVTVFWFISPSSGKPLRYHRESVRLKASSKSISVAMLPVERRVGQAKLTASLARALAKRQTRFFQLVTLGHDLDLSCSLCMWSDEPGVRVRPPDECIARSGSAPEKTRLPEQLRDAFVLPDEFDDRSLVSDSRSPELCQGSSGTLKREPDTLSLVVYGRALADRLVVPSTSNEARPSQNEDDITRIAEVISRETHNGYMPRHSLLNLVKQTRGVQDVVRLASHWSSHQHLLLEDVPGRLVPTNGRHVLSDDIDRAFERLMTMFSHLPSNRGKAFQGALTPKLQLLAAETLLSEAGVAAVPEEWAAAETWDGRSSQSQPFASSMPFGSSPPLFSSQVHSQFVQHSQSQSQSQGYDATQSQDQPDGEDPVGVRLRQYAAMNPVSRRIGGRTRVTSHWELGEDPNVITWKPGQDDEEDDAGLRRRRKLEAKRKKREKLLARIRGVEAVKAESQPLPFAIQSSQPRGFAFTQNTQPESSQFFASQPMSQIVAGPHGGRPSHVKKKQKVKKRMGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFD9</accession>
    <name>A0AAE0JFD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic apparatus protein p62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_203484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681959.1">
        <property type="nucleotide sequence ID" value="XM_062821830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFD9"/>
    <dbReference type="GeneID" id="87858984"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
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            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
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            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="53338" checksum="59B5DB984836D90E" modified="2024-05-29" version="1">MTSSSSTIIRIPRTDTDQEDDFILGEVTHSGGSSARGSKPLNLKIVATEGEEPYALTLKHDHINDLRSSTSSCSPTEWESILSSLFITASPVEGIEAGAEVDSPKGSKKKSITITIRRRIAGINQRLGALTLIHSPSSEIQLFDWCSQLAISRQTALTSVSTSAVQVADLEARVADLKAQLEELTQSKVDQETELLQKFRALLNEKKARIRQQQQALSSRARPRPDSQERLSSVIESARSKVNVDSENPLDDEEEEEEEEEEEEEEEEEEEEEEEDGGAKIGRIGGRGTGSATKAKTNTRTARVSRPGKRKATKDVSSDDDDDDDAEFEKMDVDDEPGPEPSEPSSKTTMGQSSSSKTLDNEDTDAEDEDEEGESGNNKTSDRNTPDRDNDDDDETASEPDEEDETVEAGEKDLDVGPPPSPPPPARRQGATAVASSKTTTTTAAAAGKGKGKETPTPPVSHTKRAGATATRASQPAAAAAAAVDEGSETESDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFG5</accession>
    <name>A0AAE0JFG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_572908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681292.1">
        <property type="nucleotide sequence ID" value="XM_062830525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFG5"/>
    <dbReference type="GeneID" id="87867679"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="523" mass="55722" checksum="FCFE731F5EDA15F5" modified="2024-05-29" version="1">MAPHVTPTTKLQIIGAFKLLRFLRSRHQFPPGTISNNDIFRLFSVSRTTGYRVLSEISVSADLTASERAALDAETAAALEEEENARIAEIINNPREETRGRKRKLTERDVEVIEAWLDRNGGRGEVKWKDVPVAAGLGVIPGKDGRGVVSGVTVKRALGAWRERNKEVDVEDWTRARGAGGLRGSEKARERWGRPKGGEVESSGDNDGEAEAEASGTGAGAGAGAGAGAGAGAGNGQSAGEREGSSGSEESESEGESVVETGAGPSQAEPAAETATASGSGSAAMAPGMATGNGNGASNAGESQGQEQQQNTKKRRTQTEPQGPDPKYLWKNRWEIERAARDAQARRQAEAMAEARARVKAQAAKERYRLQRQRKRQQQKLERQQKQQQQQQQQQQQSYTAGQQQPVQQQPVQQEQLPQPQQPPPQQQQQQQQQRPYTSMSFIPLPTYGQQNGVASGSGSGSGSGPSSANQSFNGAAVGSSWNVNPNPSIDNGSVVNVQRTGGGGGGEAEDIMMLGRISGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFM1</accession>
    <name>A0AAE0JFM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_442851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682095.1">
        <property type="nucleotide sequence ID" value="XM_062825600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFM1"/>
    <dbReference type="GeneID" id="87862754"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3345482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="335" mass="37409" checksum="0C3816C4448C1C7A" modified="2024-05-29" version="1">MAVGVQEEQASFDTCSALIGSPDRFTLEAENTDGHTALGLSIIRGHLATTQMLLDQRYWSMPRSSLDKALLLAASTLEEQKSCGICSALIKYGAKLDEMNVEGDTALHVAAYRGHVATVKLLLDKHPKRGREPHVENKKGATPSSLACHYGHLTTLVALDEHHSHYHAPFALKECHKLMEIASFNHHDEIVKYLFKKYPYLHLSRILLDRIPQAESKSETRSEEFLKVLSSTENLRIGAEILELVIRSREFRHLFKELLKSPKLQTSTFDWYCLVSKIKGDALLLADLDEETKDAIEGFKQTSHLFSIGDLGLLGNEPSTPSSPSWSDTLPAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHG7</accession>
    <name>A0AAE0JHG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CP2 transcription factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_159601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683009.1">
        <property type="nucleotide sequence ID" value="XM_062821213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHG7"/>
    <dbReference type="GeneID" id="87858367"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="7">
        <location>
            <begin position="245"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="795" mass="87496" checksum="3B8A2473116AF593" modified="2024-05-29" version="1">MFRQRTSSQKPADDLLAHFRQQFPEVAAATSSSGPAPPARTATTSQAGIAVTATERAQSLGHDAFRDQDPTPRATNEPWRFTPSALDASQFTFSQFAAGHGYYTPTPGGTNTIYHPTAGDLHTPTLGLGMGLGTPLSMPTADGSLHPGAHMELGGFHHSFPQFQHYNAFITAAPSQPSYAPSSFLHQDSGFETMDQDGSPIDSDQADERMGNMDGSFQQSPMMGMGFQTRQFGMPIPMQLPPSAERFRFHTTLNAPTAMIKNTDEIPVTYLNKGQAYSLSVVDTTPTLPIAPGTRFRTFVRVSFEDEQQRLKPGVCWSLWKEGRGTNEAHQRGGKLQAVEFVEASQPAEGDDKRTRIELESASFDGFSVIWTPGINGSVDCNIAVRFNFLSTDFSHSKGVKGIPVRLCAKTQPYLPNSPQSPNSNDGAEICFCKVKLFRDHGAERKLANDVAHVRKNIDKIKQQMQQAESGIKDFGKRRKSGVAQMKTQSSHRPGKIQKHKRTWSMSSASSAGGGPRVQLEEDLTMKLQTQQDMFTSTRPVSVLFLRGDELDDPDLHPVVLPGESLDLTKLEARENNAWRSERSSIGGSSLVSPSPSSLSLASQMSVSGSKPNWTELHRFNSGDASKGLSGQPTRVKQTTDDDGNLTGWIESLDVDSTYRPPPERATKPVACFYVARLDPGNPQGQETYRAVYLMQRSLHEFVMRIAQKWNLDPSSIVRTTRVLPRGIEVAMDDDVIQELQEGQDMKLEIHEVNVNNSGVKREWEMAVDGPEAELASPARTNNSSQTAYELRLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHX8</accession>
    <name>A0AAE0JHX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Regulatory protein ral2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_423413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683048.1">
        <property type="nucleotide sequence ID" value="XM_062824455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHX8"/>
    <dbReference type="GeneID" id="87861609"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000142">
        <property type="entry name" value="Regulatory protein ral2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="744"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="924"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1074" mass="114592" checksum="B7451D1B50A598AC" modified="2024-05-29" version="1">MAGFGLTSPTSGQQPPSAIDLSRFSDSESEEQTSRSPARTPSEFLSSAFRGIKKITPGRDEFARLTRQPSQRGLRRPSEPYIPAAERPSISSPIPIQSPNPLKAQHARSLSLQDSLAKPLPEPPPPTLSPTSPSTPTPFTQQPLETIEDTEESWMDTSRTSTMDSASSMEMGGGGMYMRSQDTARQDVSMSSSQSSFASVHRSEAGDGRHENLTPRSNGPMSAGPSPNGGQGRSQAAGGGGPQPMPSPSQHLSGLMCNVHRTTGREPPPLVGATTTVLGDKLFLDLIRRHWSKIETTGDVPPPRYFHSMCALGDTKLVCYGGMSPIANQNTITQDQQPEVKVMSDIYIYDAPSRKWTFVQTQDAPQGRYAHCACILPSSAAFASHRAPFSALQHNPSSGNPNEGRIGINIDGTDGAEMVVIGGQDAANHYIEQISVFNLRSLKWVSTEQLGKSCGAYRSVVAPLPPSLAAKIGKPHPVSGRQDPGATTQEAKDAGSSMLIYSNYNFLDVKLELQVRSSDGTLVETTMKEQYSPPGLRFPNGGIIDHYFVVSGTYLTSSKQEYALWALDLRNLSWSRIDAGGAVFSQGSWNRGVLWNRRNTFVVLGHRKRSLVDDYNHRRINFSNVCMVELEAFGFYDNPRKTAPMSGFVSASSPYTGPGLSLARKAGFTAGGRQHSRAAEELGEKALTMRELADMDILCIGGERIPVNSRIVARRWGPYFVQLLREGTACQDGSDVMTLRSNSISASSGMGRSSNMTPTPGNRSTMESQMSIYSGSSSTGKPPSTAATSVAGSIMSPTGVDAAALNSAPTPRTLAPNNRPRCLYLPHTFLTIQALLHFLYTSSLPQPTSPLCTPQILCSLLQIARPYRVDGLLEAVVERLHNLLDSRNAAAVFNATAMAAGGGRGIDGTLNPNFFPPADLDGLVSPTGSMPPSANGSEYGGGGGSLASRTAALHINTTGLQQGRRPSSAELSATNSVSGSEWSDMGEHERERGGEIWSGELSSVIGLQKRGLRGLMEGRRMRERTGTNVGMGPGGPGPSGHGGPGGPSLYGSTPTATSSMQQMQQRVGMGMGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JI34</accession>
    <name>A0AAE0JI34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_160757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683036.1">
        <property type="nucleotide sequence ID" value="XM_062821231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JI34"/>
    <dbReference type="GeneID" id="87858385"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="163" mass="18804" checksum="6D608994601B004E" modified="2024-05-29" version="1">MPSASFNGRRAAGYSSAKQFQPQTENSEFSRQGASHRKVVNIGDILDDRYRVLHKIAYNSKSVSYLCRDLEDDKWRRVTVARSHQFSTAMDEFEKGAEARRRLGEKEAERQGFCLKVFSVAGPNGVYMSLVYPMNSHEADLRFCAPYDEAYFLDQLRQWESLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIS7</accession>
    <name>A0AAE0JIS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_178226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683624.1">
        <property type="nucleotide sequence ID" value="XM_062821474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIS7"/>
    <dbReference type="GeneID" id="87858628"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="9">
        <location>
            <begin position="462"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3348542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="596" mass="66661" checksum="D2BE2D0713B008E3" modified="2024-05-29" version="1">MVYDRGITVLYEPTNTEVDIVFVHGFTGRPKSTWTLDAAKVKKRTKTNRGRPSGAVFWPQDLLPATVPTARIFTYGYDTKIRHFLQGQISRNTVQDHAWDLLCGLEAQRRSFQEESRPLVFVAHSLGGVVVRDALKQASHCQATHPHHHALFLSTISVMFFGTPHRGADPRSGLHRVISASAIGIGMNVNRHIMDTLLPTIGRATDVDDFKMLAWEAKWTVYSFQEETGVGLLFGKKVVEDSSSYLGPPVAETIQHISDNHMDMCRFHGLEDPGYLKVAAAFQRIFATDDTRGLRVRSTPSPPTGFSGSSSKGPHPTRCAQATPSPSEQPSGASTRQQLQINVEDVLSEYTHLTPGKKTLHDKNLLSAGQEQILRSVNTTLHAPATIYASSDTSPSSLDTECQMDIHPEGEPNIDLAIMKEMKYLEAKNKKIDLETKKKLFDMLKFDELGARMHDIQPAFMQTCQWFLDNPQYTKWKRGNEGLCDSGFLWIKGKPGTGKSTLMKYLYSIHSRQSDCTVISFFFNARGAELERSTLGCYRTLLFLLLDGREEVWKAMDHIDNVGRSYIAANGWKIGFLTETITNAVELVAKQHPVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ34</accession>
    <name>A0AAE0JJ34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_178536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683638.1">
        <property type="nucleotide sequence ID" value="XM_062821476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ34"/>
    <dbReference type="GeneID" id="87858630"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042036929" evidence="5">
        <location>
            <begin position="17"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="59"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3348556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="422" mass="46171" checksum="2ABF2FA0F59D3C82" modified="2024-05-29" version="1">MRLITILAGLVGSSLAAPTNQPHGDALATRAPWPNGPLVTSGRWIRDASGTNLTYAGVNWPGAADVMIPEGLQYQSIATIASKIKSLGMNAIRLTFAIQMVDEIYSNGGKDITLQKAFTQALGSTNGPKVLNQLLAKNPQFTASTTRLQVFDAVAAECAKQQIFVHLDNHISKGTWCCSTDDGNSWWGDTYFSAANWTRGLAYMASHGKQWTSLMSIGLRNEPREPTSGAAKSTYNWQTWYTYMRQGAEAVHSSNPDLLIFLSGLSFDTFLTPVVRGTALTPGTGKFSFNDFPGYANKLVLELHNYENSATNCNNLQNNLYNNGFQALTSSAVNQFPVVMTEFGFQMDASTWKGTYASCLASYLPAQKAGWFIWVLAGSYYIRSGTQDHDEGWGLLTHDWSAWRSPSYVNGALIPMVKNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ70</accession>
    <name>A0AAE0JJ70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_420184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683919.1">
        <property type="nucleotide sequence ID" value="XM_062824259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ70"/>
    <dbReference type="GeneID" id="87861413"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3350624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="59" mass="6719" checksum="735F305885CDFC76" modified="2024-05-29" version="1" fragment="single">LFIQVDGCSSPSKSHFIRLLFIKFKEIVTLNYLPDPVTRTTPTGIFTTNINRSTIYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJI7</accession>
    <name>A0AAE0JJI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_455019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683801.1">
        <property type="nucleotide sequence ID" value="XM_062826217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJI7"/>
    <dbReference type="GeneID" id="87863371"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3350506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="543" mass="59815" checksum="0AAD92BE247E0099" modified="2024-05-29" version="1">MSGPQYGAQPGGYYNNNYPPPPPNSYQMNPMPNDGNYGQQPQQYGNGYGNGSGYAPPQGPPPNGYKPPPTDGYGGPPPSYDEVFKVQKPKYNDWWAGLLFLATVAGFVAVSAISLHGYADNRSQNNGSLNGQRNTFGLTTHTIYLFVWVLICAIVLSYAYMWMARKFTKQFIYATGILNIVMGLVTALYMLSRKYYSGGIVFLIFVVLQALFFWSCRSRIPFSTLMLQTAIDVAKVHGHVYLVSAVGGLIGTLFAAYWAITLVAVYVKFEPDPNNAACRTAGGCSSGKVIGLIVFITFAGYWISEWLKNTIHTTVAGIYGSWYFNSRNYPTKVTRGALKRSLTYSFGSISLGSLFIAIINLIRQLAQAAQQNAAQEGDILGTILWCIFGCLIGILDWLVEFINRYAFCHIALYGKAYFAAAKDTWKMVKERGIDALINECLIGPVLTFGATFVAYACGLIAYLYMVYTKPAYNDGGGYTPVVVAFAFLIGLQVCNVFTTPLTSGIDTIFVATAWDPEVLMRDHPDLYHRMVAVYPHVQEAIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJV2</accession>
    <name>A0AAE0JJV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_586326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684295.1">
        <property type="nucleotide sequence ID" value="XM_062830947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJV2"/>
    <dbReference type="GeneID" id="87868101"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="220"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3351000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="334" mass="37238" checksum="5910CB6CB1120DA8" modified="2024-05-29" version="1">MPAVKRKAPPTLGAKLQRRVRPRFEAEPDSDVEGSSDEAPSEEEGGGFHTGSDTEEEDEEIEEGSEAGSDDESDAPSEHGGAGIDASQLSFGALARAQASLGALKKKKKSKGGDEESSDDEEKEEPNWKTEIEKGMKAKAEKHHRTSKHAPVEMTSKKPVSRRRDFLANNSEPAKPKSRDPRFAPPGIGGGSSGGSKGVVDEIKARKAYSFLDDYQEDEMKQLRMAIKKTKDAKEKEQLQRALLSMESKKKARVRKDKERELLSEHKKKEKELIKQGKTPFYLKKSEQKKQLLVEQFASMKKSQVDKAIERKRKKIAGKEKKALPLARRTAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJW0</accession>
    <name>A0AAE0JJW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_506163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683896.1">
        <property type="nucleotide sequence ID" value="XM_062828047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJW0"/>
    <dbReference type="GeneID" id="87865201"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042235119" evidence="1">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="127" mass="12840" checksum="3FE5DBC3755A0CCA" modified="2024-05-29" version="1">MLFKATLLSLLAAASATAIPRASSTEINKCLPNQISIGGTCFNAGSFCGGFAAIPCADKNQICVDDPRDDCDPKNGGSDCGGVCIKPLFCGGFAGIRCPKGLTCVDDPRDDCDPENGGADCGGICVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKA8</accession>
    <name>A0AAE0JKA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cholesterol oxidase</fullName>
            <ecNumber evidence="13">1.1.3.6</ecNumber>
            <ecNumber evidence="11">5.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholesterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_111366</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; cholesterol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="13"/>
    <dbReference type="EC" id="5.3.3.1" evidence="11"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684522.1">
        <property type="nucleotide sequence ID" value="XM_062820581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857735"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="185"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="18">
        <location>
            <begin position="615"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3351227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1365" mass="151281" checksum="8740DABE9C1C9792" modified="2024-05-29" version="1">MDRLSAHQSNGAPSPPPTPAYSGDQLGVKTDTTGLFPGSTHINGDSDASFTESPDSDFPPTPRRSPKQEPRDFPRSNPVSHQIPTEGIHDHQAGGPRARANAKVRSYVADQDRQAFPRISKPVELIQVAYDVVVIGSGYGGGVAASRMARTGSSVCVLERGREKWPGEYPTGAADAFKELHTSGTFAPGSLDGIPVETGDPTGMYHLIFGKGQNAVVANGLGGTSLMNANVFMEADKGTLAMKAWPPEIRNKVDSLDKYYEKVEKVLEPAEYPDDWPELPKAKLLKKQAQYMGYGDRWRKVKQTTRFQNGPNSCGVEMSASALTGQDATGVNDGSKTTTLVTYLADAWNWGAELFCECEVRYIEKAKDEDGNDDGYLVYFAWHGRNRGHFKANLHGDLMWVRARKAVFLGAGALATPEILLRSKAMGLEMSNLVGQNMSGNGDILAFGYNTNETVNGIGRAYPSPYNPIGPCITSVIDCRHNLENPLDGFVIEEGSVPHALAHFLQAMLDLMPGSEEPKNLTVLDKAHSALARYGSRFLGPYFKKGAIARTQVYLIMSHDSNQAMLTLQDDKPVLEFVGVGRSDHVKKLNALLAQATEAVGGTYVKNPFDAMLGNQQVTVHPIGGACMARDNTGRTGVTNHVGEVFTGLGSETHGGLIVTDAAVIPTALGANPFATIAALAERSVEAYCQRQGLQISEEENGVLDLFGEPQHKPKQHLPQRTVSKIEAVEEGYSLGYATRAIQMAKELCSSGMGFTEVMSGFIHHDPNMNTDERSTYELAYRTAKSHCESARFFLSVQAFDTLRTLEHAQHRAMLTGTFVCPAIPGSPFMVRRGEFNLFIIDDKAPGTRNLTYDFDMTGVDGRRLHFHGYKVVDSSVALNPLQFWRSTSTLYVTISEHVDGMCSNLDDENAWRRGKVLAKGIMNIQPKDFLSEILTMTPTGSNLLKKVASAASFLTFFTRKSLSLFMAPLTPLEYPSMLPTGYINNTPPKKSFAIYADDGVCTRLHMWEPTHYPDNDKKNIKNLFMVPGAAVDHHIFALPTIRYNAVNYFRRAGYRVFITVHRIGQLMVAENSWTTYDARLDIKACMQYIRENYGREKIYTIAHCMGSVALSTGMLDGTIPTDWFLGVSCSQVFMNPIWQTMNLIKATTGPYDKIYKALAGNWFSCSTSRDDSYVQQALNQLLRLYPQPRKEICNNAACHRTSLVFGRCWNHSNMNEATHRQIDRFFGGVNMKLLHLLMKQGAEGHVMANEPLCQRLDTPENIQRLKGIPFLLFVGRDQAVLSPESTERTYEILCDTFGTNDTSYKRRVVPGYGHLDVWMGRNAWKDVYPFVREEVDRVCRGETYKFVEPNDEFKEMVDSGELLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKN2</accession>
    <name>A0AAE0JKN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_419701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684717.1">
        <property type="nucleotide sequence ID" value="XM_062824230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKN2"/>
    <dbReference type="GeneID" id="87861384"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="184" mass="20728" checksum="8C39FCAF17525EEF" modified="2024-05-29" version="1">MTNSASEVSAQSDDAVHCAFFYGTLMVPEVFYTVCYNSKTVPDVIARQHKFSPAILHGYSRRRVRLADYPGITEDAGHSVFGMFAEGLTKANMDKLDYFEGAEYERRTVKVKLLEKVGDVSGEGNVEGEEREAQVYVFMPTQNLEEKEWDLEEFKRDKLKLWSRGDHIFADCDPAKPATVAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKS0</accession>
    <name>A0AAE0JKS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_109086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684458.1">
        <property type="nucleotide sequence ID" value="XM_062820542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKS0"/>
    <dbReference type="GeneID" id="87857696"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="344" mass="38372" checksum="54FFA72B9D419D75" modified="2024-05-29" version="1">MTAKYAKDQSAGFTNRIERITIVGAGGTVGSTIVEELLATGRHTVTALTRPGSTNSLPAGLKTIAVSYDSSDGEAALVDALGGQQVLIICLSPQAAPDTNHRLVVAAAKAGVPYVMPNGWGWLWLDDEEKEKRIKSMHGEVVYQNLKDVEAQGVSSWICVRCSFWYEFSLYKSERNYDFTLPDKKVTFFDDGEKKIWTTTTRQVGRAVAKLFSLKELPEDENDQDLTVARWKNRPLVVGSFNVSQRDMLDSVHRVMGTTDEDWTITKESSVARRERGLKLMATDPSHRFVLALYASIFLPDEVSWFGKATFDQEEVDNQLLGLPKEDLDEATKRAVDIAVKMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKS5</accession>
    <name>A0AAE0JKS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_458072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684789.1">
        <property type="nucleotide sequence ID" value="XM_062826379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKS5"/>
    <dbReference type="GeneID" id="87863533"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041932829" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="104" mass="11960" checksum="6C1FB590AC89CACE" modified="2024-05-29" version="1">MFRFLQHLSIILLGMVTALNKQKIPTTASLFFTNTPSFYLLKLRLSNFDQASVKWDEVEDTNGCPHLYGNFGAKDVVDVKEFRRGEGETWGEVFKKEEAKAWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKS8</accession>
    <name>A0AAE0JKS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_568683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684775.1">
        <property type="nucleotide sequence ID" value="XM_062830399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKS8"/>
    <dbReference type="GeneID" id="87867553"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3351480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="230" mass="25233" checksum="824645B406641356" modified="2024-05-29" version="1">MTKQKEYTFQRDAGVDVNVSPEWYTLASPFSWCAIGAESGSNSGGKIGQEFPKFGENAQLSPMLLQSLADKGLHQYSVERCILPFMLSQLLGTCNRRCGLFWETVPWTTARGGNIAHGGPCPCPIPYLLSPVRSLLGTQITGRTPAETVSTLPCTGSTLVRNQCNLDPGEALRLSFHSHWDSVHLSLLQPPNTITFRLRLRLQRSGSKPRDPMAVCALSQLSGTPHLRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL73</accession>
    <name>A0AAE0JL73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_129771</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684955.1">
        <property type="nucleotide sequence ID" value="XM_062820785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87857939"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="590"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1112"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1136"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1176"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1223"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1253"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1292"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="182"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="419"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="741"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3351660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1346" mass="150863" checksum="3921A59B2385E513" modified="2024-05-29" version="1">MNGGNDAYNASWRSSQSFDRRRASHDHRPGLYTLGSNQSTASIFEDVEMAHDELYSGPMAESLPTSVSAFNHRRARADSTTSFSFYQEDIDERFETGEVASIEDLDELPFEDDYEDDVGASEMGSSDLERQAPDDEYMLNRRSSTQSRRSGHSRVLRRDSGVSASSGHGGNRTSQKVYMVNEDLYIAIAGFRTSTLGLAVYILICLLTFGVGWLLFRWVPRWHVKLVGRPSSLRDCQWVVIENSWNEMAILNVDSKPYGRVLSTVFGSPGKLANYSLDEDHDPIIQDLRMINYRYVRFFYHPLKDKFILCNGWKDPLWTDVQTIRSGIDSEEKSHRDAVFGGNLIDIEEKSTFRLLADEVFHPFYVFQIASLILWSVDEYYYYAVAIFVMSVGSIVATLIETKSTMKRLREISRFVCDVRVLRNGFWRHVSSSDLVPGDIYEVSDPSLGQFPADSLLLGGDCIVNESMLTGESVPVSKTPATDQSLRNLDLGASTVLPEVAKHFLFCGTKIIRARRPQDDHNEEAVALALVVRTGFNTTKGALVRSMLFPKPSGFKFYRDSFRYISVMACVAMVGFAASFINFIRLNLSWHLIIVRALDLITIVVPPALPATLTIGTNFALGRLKSKKIFCISPQRVNVGGKLDIMCFDKTGTLTEEGLDILGVRVVNRTNNRFSDILDNPDDLVPRQDHGTGIKDSTDTLKAALYTMATCHSLRSVDDELVGDPLDLKMFEFTRWSFEEGHEGGGATDGEEQRTLQPSIARPPTVDKGYTDADRQDATQNGRAPFELGVLRSFEFVSQLRRASVIVRTFGQKSGDIFVKGAPECMREICKPESFPADYDDQLNFYTHKGYRVIGCATKHIPKLSWVKAQKMTRHDVESDLDFVGFIVFENKLKPATAPVLKELAESNIGSVMVTGDNILTAISVARECSLINKTAHCFVGRFVAGHSRDPNAKLQWESIDNPIYQLDDRTLLPLPPPPEGDASLPYDISNLRNYSLAVSGDVFRWVIDYAPPEVMRRMLVTGKVFARMSPDEKHELVEKLQSIDYCCGFCGDGANDCGALKAADVGISLSEAEASVAAPFTSRVFDIRCVPEVIREGRAALVTSFSCFKYMSLYSAIQFTSVSFLYASASNLGDFQFLFIDLALILPIAVFMSWAGPFPELCRKRPTADLVSRKVLVPLLGQMFICIFIQTMAFIAVREQPWFIPPKVEHEKVNIRNSENTALFLTSCFEYILAGVVLNAGRPFRQPPWTNWPFVAAIAATLAFTGYMILGPAAGLVSLMDLTPISWDFKMFIFTLGIMYFVLAWVGEHVIFQRLARLIGKVSQSLTKEPKKRKEYKVILERMIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLP3</accession>
    <name>A0AAE0JLP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_420199</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685244.1">
        <property type="nucleotide sequence ID" value="XM_062824261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLP3"/>
    <dbReference type="GeneID" id="87861415"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11000:FF:000002">
        <property type="entry name" value="Fe-S cluster assembly protein DRE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="227"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="304"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3351949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="330" mass="35000" checksum="491D5FC4F568C635" modified="2024-05-29" version="1">MSPITLDLTSDFDPAITTGTGSSSTQRTLLVAPPSVASHEERISALFSTYPRDTTDLHMLDRLAAGLVTLPASTYDLILVLTDPDGSRHAEASALLSNRAVWALLVPALKAGGKLRSEDGTLGTNSATPEAREAVLAGLVAGADGFTKPEYAEEEAVPLRFGLKRKNNPNAVAPIQPAAQVVTAAPAGVGFVTLDLDDDLDLDGENDDDVIDEDTLLTEADLRRPIQQPPECQPKPGKKRRACKDCTCGLAERLEAEDKARRDKADQALNTLKLKSEDLLELDLTVPGKTGSCGSCALGDAFRCDGCPYTGLPPFKVGEEVSILNNVPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN36</accession>
    <name>A0AAE0JN36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_562285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685738.1">
        <property type="nucleotide sequence ID" value="XM_062830195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN36"/>
    <dbReference type="GeneID" id="87867349"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="479" mass="51486" checksum="2A45A94898984C19" modified="2024-05-29" version="1">MPADEESSHHSSIALRPYKACTLRESIAPSYAEELLNLLDYHHVSEREYSRSDEELDTSPQITPSTSHEQQVRLKVIEALTNMSVHLSTAEIDAVAGLLMLRRDTRGPCRFSSSSSVHAAGHRKRTVSGSVKDRVITATQERPRTKQIVDTQGEVVVPLTLQVPDSRSSAQTLSCSRPEPAAGQYDAAQYQSESTQVPSASLVASHSYHSQNPKADNPNNVNELYPRQPVKKKKKKKKCFPNASQPQHLKTQTTPPSTPLGNTSNPSSTNIFQETQHTTSRALHTRPTVTNQQAPASPNKPTLILTAPTTPLHQHQSQHQSQHQPQPPPSGSCSESQPPSQPRPRSLFPNPPSTSIPAIPNPAATTKPPLKKRKKYGTAYEVSRARQIQATGVPRLPGPCHSCARRQRQLDEIAAAAAAAAASNAASNAAVGAAAVGAAGGVGGGVLTGTGIGLGLVWNSDTQPLPQIRVLLLRYVDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN38</accession>
    <name>A0AAE0JN38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_448875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685930.1">
        <property type="nucleotide sequence ID" value="XM_062825924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN38"/>
    <dbReference type="GeneID" id="87863078"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3354552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="57540" checksum="AA4B4A767D562924" modified="2024-05-29" version="1">MGQPSSEASNAIIYTTLGVFLIMGTGVAWTLRNQTKGEYLAGNRTQTAIPLALNFIASALGSGILFTYPEIATLAGLQGVLVYALASALPLFVFSSLGPIIRRKCPEGFVLTEWTRQRYGTVTALYLSFVTLVTLFLYMVAELSAIGQVVETLTGLNGLPVIIVECVITTIYTSLGGFRISFITDNIQGAMVIGLIVIAAIAIGVETKIDTSLIEPSGLLKENLLGWQLLYILPVAILTNDFFLSNFWLRTFASKTDRDLWIGVTLAALIILIIITMIGCTGLIAAWSGVWPGSDPENPLPGSMTFFGLLENLPAWVVGFVLVMSVSLSCAAFDSLQSAMVSSASNDLFRNKLNVWWIRGAVVLVIIPTVVLAIKAPSILQIYLISDLVSAATIPVLVIGLSDRCYWFRGFEVVVGGLGGIFTVFIFGAIYYKDAYKGAQLMLLEDGIYQEGWAAFGAFVAAPVGGLVWGFGALALRLAVQWVQAKRKGVRFDALDRPVVMEGEGDAVQYVAGGDLETILSTGQESGAGKIPGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN72</accession>
    <name>A0AAE0JN72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase UBR1-like winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_5513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685621.1">
        <property type="nucleotide sequence ID" value="XM_062829799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN72"/>
    <dbReference type="GeneID" id="87866953"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="2">
        <location>
            <begin position="212"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="719" mass="77521" checksum="EB1B1AC65255145C" modified="2024-05-29" version="1">MSLTIPDNGLLLEGPTEMAARRPTHAFAVPLSAELVAQMIESAQNGGKIQLALNDDPAILIEDQEVPLQPDLLTEPVDYELFYTNPNKPTRGQRVLGPVMSIFDYYKRAKARKAAQTAKPSNSIEGAVENLKNSFAKVEADKRENSALIVEGLPSKKGAKINPGKARLLGPQTNGASRSISVSPALSGLGSPSLGPTSNGPGDRLKQQKFPIIHELAAQPLTFEELLAKYDGDEQEFHPILNKVADFNSDLQKWDLKKMYWKELDVFEYAYATDEDRQKAIDNAIKQYDRMRLGVSDPLWQKLLPKGERGKGICLSKLHATIAKNIQSAPTPNRITGTASPSGAETEKGEPMSRSNSQTGVTKKKVSASVAQAKRIATASANAKKTGRPSAAKAAASKVASPRVASPKVAPTKVAGSKGPAAKGGRILSKEIITDSDSDEDEVPLSKSIGRTQGTAAPAPGPKKSGPPVEKSKTAAKSIEVPSPKTNQKPKAAPVRAVAKKKVEETRDTIRAQPIPRTTKPMVSKRPRDPEDDDSSSSGTPLSQRVKPVAKPKVRPDAVGKSGSTLSKGNKYASPQKSSPLASSPPTNASDNEEDRRTIVSRPQKRERERERDREVIVSSASSNAGSVNEDVGSRSKKRPAPSDYASGNIGSKRPCLDPDLLSRAEKFKRAYTRYEALHREVSSAEDPSPDKVDSLMRLHARLQLEKKEIYSAATFGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN88</accession>
    <name>A0AAE0JN88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_562173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685651.1">
        <property type="nucleotide sequence ID" value="XM_062830190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN88"/>
    <dbReference type="GeneID" id="87867344"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042274599" evidence="2">
        <location>
            <begin position="24"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </evidence>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Yan M."/>
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                <person name="Ng V."/>
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                <person name="Ohm R.A."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Mondo S."/>
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                <person name="Yanf M."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNI4</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686219.1">
        <property type="nucleotide sequence ID" value="XM_062827949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNI4"/>
    <dbReference type="GeneID" id="87865103"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3354841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="666" mass="72315" checksum="01C50B1DDA2C57F7" modified="2024-05-29" version="1">MALNLQPREDGLVSLQVPKASQACINCRKQKRKCDKSVPTCGLCARMNRQCDYSDSPSAPTASDVAALQARLAELENRLALAGKETTTTSSSSPNNNIFTPETNNNNVNTQQHQITPPVINSRGPLWLPAGGSANRFPSALLLDTDVFKWAQLSIPAPPVAVPRDVYDILSRGNTVQDCAAEYFDTVHRWFPFISKKRMTLGHTLWEAGPDLAMLFLGMKLIVTLPREGMESADNPLYTAAKGLLALLESGGCVSLLCLQGMVLVALYEYGQGIYPAAWMSVAGCARYAEMCGLPGFKESWAVLGAVTTWTESEERRRVWWAIYILDRVICLGNKKRFVMPEPEKHYLLPVDDDAWDNGDPGRALSAGITTPLEQPQGRFARLVQSSMLVSRTITHIRTTLRNQQLGGDTDPFDINEVDDLINTLTSFSTLIQQELLPSLGSLTRTQSNNTSTSSTSSTSPPPPNWHFLTSNSVPLNPPYHNPSSPSLLTSPFDFSSSLISPQPQPLNPLSLPPLSLTHSALFLLYDIHCCPENLLDGSGARGFENLQPKTANQHALQVRSVAGLRSLSSGAVRELCMELLDAGLAKVSPLCLDEMYNGLATLRWLWKEGGDNGGTGEDGSPGDGCTGGGLGVMQAAEDVGRLSSRWRLAEEYLGLVGFHDVGGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNV2</accession>
    <name>A0AAE0JNV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligosaccharyltransferase subunit Ribophorin II-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_417240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686335.1">
        <property type="nucleotide sequence ID" value="XM_062824078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNV2"/>
    <dbReference type="GeneID" id="87861232"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044250240" evidence="8">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="175"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="283" mass="30260" checksum="93AD9755CEEFF228" modified="2024-05-29" version="1">MRFTQALLLLAAGAAQAASSWSFDDASVSVAAKKGSDAIKEKFSQKAPLTKPVGLGSTDTVKIILTAKEDGKAKRPHQAFVTIKEQETGLEAPFPLTVKDTGKAVVQISQKDLPVQFLLSPKPLKASVVIGSFGEARAVNTPVFDIELQTDPNAPVPKYEAPVRYGKKPEIHHIFRPGPQSPPKVISLFFALAVAAMVPVLFISWLLLGANVNHLTKALGAAPLSHVTFFGSIVAMEGVFFMYYTSWNLFQVLPVAGVVGVVTVLSGTKALGEVQSRRLAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP34</accession>
    <name>A0AAE0JP34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_438362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686459.1">
        <property type="nucleotide sequence ID" value="XM_062825368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP34"/>
    <dbReference type="GeneID" id="87862522"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="837" mass="93479" checksum="AC924E38FFCCA06B" modified="2024-05-29" version="1">MAAPPPPASRNDSPSKPARDELKQYYLCSAWKFTDRAVDHLIAKLRDQKIQDADFSWEPKYRWIKTISPASKEAEIRKFWQELVTEVEQDAYERAEDDIIEYNFTLKHGFKDEMIEYPDGLSDSSDGDANTPSSNGSDENATRNTFPPQFSNRFPSLGTWTKLEGEDPSLTIQRVLNEDDRLQLQQDTGVEISYDLGKVVYLGAESQDAIKKAKEKLDVLLESITAPGPNLQFVLYAEGYKDPVLNDFKSDIRYLANIDPKLPSTTLLDPILFPDLAQEYARMYHVGSSIRLCPYNSVLRAHSSLFGPEILTRKRKKDDLLAPRPVLTTKSERVLTDTSTASVDGLADPILNGNAINQKLNVNNWLNAIPEGLSSVPTQDALALRPATPGSAVLVPTISWDMPALVPTQSTKSSDKVESSKKDTNKSTVKDEPLSFDQEKKQKSIQQVLEAVPRFLGNGPYLRGEVIVTADFGRVIVPELAANAMAFNGKNTESNGWKRRDLMLTLHRIRPGTTGKESLVAGNVCFTKILSTHGSDLETLINIKDEKTSQRLWQKAPSKCWTVYSFHCQLTGKTPDQFLVEITDCANGTFSYTIRGLTEPGCSQKLIYDLRITRTVHSPLLEIRYGKFAKALLESLKIPEPKSDDKDNINLSFNIDSQFKTTITSVRVLSKWRHLSQDKRSALDITEVEQLEIKYNPARPGMPNSAGEAHSWEPRTHGREAKGEKQRWYEASVSSLNLEELLAKNKSLKTGERAEWSHPELKKDGILESLCCPALQMLKHMDQVGGTEKNKQEGKPGTAVKRANERPWIVPGYAAADKPEAFGQGKGVRKGKGGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP85</accession>
    <name>A0AAE0JP85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_451197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686592.1">
        <property type="nucleotide sequence ID" value="XM_062826041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP85"/>
    <dbReference type="GeneID" id="87863195"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3355214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="75" mass="8756" checksum="FDB6F472B19E2127" modified="2024-05-29" version="1">MAYIRFDGDWDPSTSLAEQARRLVTDRLSRGVTLGELLDDQRACLRGSPTKTMLWLFHMFIIREIKNRFDAARPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP89</accession>
    <name>A0AAE0JP89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_449941</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686236.1">
        <property type="nucleotide sequence ID" value="XM_062825981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP89"/>
    <dbReference type="GeneID" id="87863135"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009682">
        <property type="entry name" value="PRK13203.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="14">
        <location>
            <begin position="404"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3354858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="840" mass="90158" checksum="B1DAD24FBEE2B763" modified="2024-05-29" version="1">MHLIPKELDKLAISQLGFLAQRRLARGVKLNHSEATALIANNLQELIRDGNHTVADLMALGATMLGRRHVLPEVTSTLHEIQVEGTFPSGTYLVTVHNPISSDDGDLARALYGSFLPIPPNDDSVFPLPPAAAYEASKQPGAVVCVKEAKVKLNEGRKRIRLRVTSKGDRPIQVGSHYHFIETNPQLEFDRARAYGYRLDIPAGTSVRFEPGDTKTVTLVEIGGNKVIRGGNNLASGKLDLARAEEIIAKLQAAGFAHTPEEPVGDAAFISEPFTMDRRAYAVMFGPTVGDMVRLGSTDLWIKVEKDYTVYGDECKFGGGKTLREGMGQATGRSDEETLDMVVTNALVVDWTGIYKADIGVKAGVIVGIGKAGNPDVMDGVTPGMIVGSCTDVVAGEGKIITAGGIDTHIHFICPQQAAEALAAGITTFLGGGTGPSAGTNATTCTPGAHYMRQMLQACDSLPLNIGITGKGNDSSPSALREQILAGACGLKLHEDWGTTPAAIDSCLTVCDELDVQCLIHTDTLNESGFVESTIAAFAGRTIHTYHTEGAGGGHAPDIISVVEHPNVLPSSTNPTRPYTRNTLDEHLDMLMVCHHLSKNIPEDVAFAESRIRAETIAAEDVLHDLGAISMMSSDSQAMGRCGEVILRTWNTAHKNKLQRGPLPEDQDTGADNYRVKRYISKYTINPALAQGMSHLIGNIEIGKLADLVVWDPAWFGTKPSLVIKSGLIASAMMGDPNASIPTVQPVIARPMFAPMVAKTKVLFVSQASLDSGAIEGYGLKSRVEAVRGCRSVGKRDMKFNERMPKMKVDPERYTVEADGEVCTAEPSSELPLTQSWFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPG3</accession>
    <name>A0AAE0JPG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_450600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686441.1">
        <property type="nucleotide sequence ID" value="XM_062826017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPG3"/>
    <dbReference type="GeneID" id="87863171"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="198"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3355063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="506" mass="58214" checksum="B84A714A8CA40700" modified="2024-05-29" version="1">MASDHHGAAVELKDNTVIVVLGASGDLAKKKTYPALFGLYRNQFLPKDIRIVGYARTKMDHDEYIRRIKSYIKTPTKESEQQLEEFCSICTYVSGQYDRDDSFMQLNKHLEELEQGRKENHRLFYMALPPSVFTIVSQHLKRCCYPSRGVARVIVEKPFGKDLASSRELQKSLEPDWREEELFRIDHYLGKEMVKNILILRFGNSFLGATWNRHHIDNVQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLTLLAMERPISFSAEDIRDEKVRVLRAIPAIEPKNVIIGQYGRSLDGSKPAYKEDDTVPKDSRCPTFCALVAYIKNERWDGVPFIMKAGKALNEQKTEIRVQFKDVTSGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLILDCLKGDHSNFVRDDELDASWRIFTPLLHYLDDNKEIIPMEYPYGSRGPAVLDDFTASYGYKFSDAAGYQWPTTSAMGSGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQB1</accession>
    <name>A0AAE0JQB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_59209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687195.1">
        <property type="nucleotide sequence ID" value="XM_062831119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQB1"/>
    <dbReference type="GeneID" id="87868273"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="330" mass="36265" checksum="5D7DB922A49DEC23" modified="2024-05-29" version="1">MVTIQGKKVGNIGFGLMGLTWRASKVSDDEIFPVIKAALDAGCNYFNGGEFYGPPEHNSLTVLKRYYDKYPGDVDKILLNVKGCMLPGLLAADSSPEGVRASIENSVRLIGGKGRIDQFEAARKDPKVDIEVTMKAMGEHIQAGDIRGIALSEVSAQTIRRAAKVAKITAVEVELSIWNTEPLENGVLEACAELDIPVLAYSPLGKGFLTGQVKSFDDIPEGDFRRMLPRFQPEVFETNLRLVRKVEELAARKGCTPAQFAVNWVLALSRRPGMPTIIPIPGASSPERVRENAVEIELTEEDMADVEKILKEFAPVGDRYHKHGMELLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQY3</accession>
    <name>A0AAE0JQY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase like family 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_585353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687106.1">
        <property type="nucleotide sequence ID" value="XM_062830922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQY3"/>
    <dbReference type="GeneID" id="87868076"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="523" mass="59639" checksum="769E6E2DED045F5E" modified="2024-05-29" version="1">MSPTLTPPTQKGSPRGMSTFSWLKQASFNTLCMGLVVSFIHSGIKHLSKGEQALYYFLALFIWRYLRFCLNIIGFWTYKAAPMPKSNANYYPGRDVTVVIPTVDPLGVDFHECLTSCARNGPRKIIVVTAGEDLYAKTLSAVAPVMDEFPLINFLVTRTNIANKREQVAHVIRYINTPITVLVDDHVFWNSHDLLKSLLAPFEDNQVGIVGTNKRVRRLEGLSIWCRFWNMLGCLYLDRHNFEIRATNAIDGGVFVISGRTVGIRTCILEDKEFQAGYLHEMFFFGLLGPLHPDDDNYITRFMVNNGWKIKIQYTKDTEMETTVGVGEPVHTKFLGQCRRWVRTTWRSNTTSLFTEGTVWATQPYCVYAVYLTSFTNFALFTDAALVYLFTQSSWYTDAAEPNYALAALLSWMIFTKTVKVFRYFSTYPQDIWLFPAYVLFAYFHSFIKLWALFTFWDYAWSGRKLAALTEGEKNDDNDKELSPLGIHYDEDIPDLDIGPSVSPVPLNPMAPMGPQSATLIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR94</accession>
    <name>A0AAE0JR94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_65394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687385.1">
        <property type="nucleotide sequence ID" value="XM_062831233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR94"/>
    <dbReference type="GeneID" id="87868387"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041908714" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="69"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3356008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="500" mass="54978" checksum="CC5FE26B1EA7E34E" modified="2024-05-29" version="1">MHLSSSLLFTSALLAGGINASPATNAYRRQNADLRTILDDTTPILSNTTSVHFPGSGDFFSATERWDVYRPPSYQAAITPTTEADIVSLVKMAKQHNIPFLATGGRHGYGTTLGRLQDGLAIDLSHFKDVKIDKRRETVTIGPGVVFADVFPVVSDAGFQVQTGTCSCVGMIGATIGAGIGRLDGVHGLVIDALESVRMVTANGDIVEASKTKNPELFWGIRGAGANFGIITQATYKMHKSMGDIISFDLIYEPEKNLTLFNTIANMYLPPGLTVETIMSYNQTTEKPTIIVSSTYAGGSEAEARRWMQPLLRLNPWYKDIKAIPWKKMSTDTTLGLDKEACANSQVYDIYGVNLRRHDANTWVKIFNKLAKLWNEQPAARPSAVVLETWPNQAVVAVPDSQTAYPWRDATTYVLIQMRWDAPGNPVETVADAVGREIRDDLAKTSGYNGLTVYVNYAHGDETLEQMYGRNKLPRLAKLKKQYDPSSIFGFHNPLPTSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRF3</accession>
    <name>A0AAE0JRF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_555324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687405.1">
        <property type="nucleotide sequence ID" value="XM_062830022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRF3"/>
    <dbReference type="GeneID" id="87867176"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3356028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="465" mass="50208" checksum="3DB8176EA699ACA8" modified="2024-05-29" version="1">MTYSQPRTQVYEEAPCPLTTSIVLPDAVLTGVTIQPASSPTSCCVLPTPSASLELIAFEPNATDVDSIYFYTSNNATSPYYVGTLVDGFRCLLDLSPEALAAGRLAAYLSNGESIIFDETGMHYYGAGCNTTTSVTISDFLTQLAGLPDAPPPAEADHRGRRVRRRDLPETNFTVAVQVAAAIDLFLHDPQVAFGDSPCTFVDIQNITEWDIHSWTCQYPGANSSEKSCEEKFHSWFKPDSPSPSGTGLDQTGNALFNFVPRLINRVGNNLADLFPGISEPLQHGLNWLNNAHNAVLHAADVGGGELCEILHALDEYDLILSDPGLPSLHTIGNYHSPPLPTITEVFESHTKRITKEPPRQVMPTETSFSNVTETSFSEIPDIPDLASTSISVAEDLVEAAITPFTSLGSLLDAPPEASDEEAERLPTVTVTAIVTEIVTWFGLASSAAEDSFTPDMFSRDLVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRF7</accession>
    <name>A0AAE0JRF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_453953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687457.1">
        <property type="nucleotide sequence ID" value="XM_062826173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRF7"/>
    <dbReference type="GeneID" id="87863327"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3356080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="70" mass="7958" checksum="534DEAF193E8BF26" modified="2024-05-29" version="1">MVAEPEHILEASLHQAVLLLFLSARGLISSSYYATRTWRGHVKCPVSLKARRTHDNDEWGRGERTVVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRU0</accession>
    <name>A0AAE0JRU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_59472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687202.1">
        <property type="nucleotide sequence ID" value="XM_062831147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRU0"/>
    <dbReference type="GeneID" id="87868301"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF6">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="696" mass="75735" checksum="69B2521E67C62EB2" modified="2024-05-29" version="1">MDQHNSPGSGGVSATAEASSSNSELRVNTINGESSSNSMRDIEDILNEYGQGSNSNNNSNGNNSNRNEESSANVEESEDQGQQNTRRRPQTLGDVMREPGSRAPDVMVLESMPEESSSRNRVAALNPKEDLWLSTADGRYNSTIVPLRVGEAPRAQTFYVHKHILLKVEYFEKALCGNFRESETQSIELPEEDPAIFHYLIAFLYEGKYEPIKPASSVLVPDQQKGKGKDSSVEANGGGGVDSENNNSEDSELDTDLSAAPAQRRRERQRRRQQRERQREWDRVNGKHPGRHRPNCGCPRCVVEPGPPCWSCHAPRSPVPPPGIGAPYTPTGTRPPFPHPPGPEYHHRPYLERLLQGDGLGAAADRRRGRARLAAPPPPPPPPPPPPPAANQTLPPAPPAQASSSSSSNQPPSFSTNSDSYLTEGNTRLSTPADLRTWLLCYEHTLSVYILANKFLLDDFKAEIARHAIDMLESAGTDAAVPQVLFLCKRLWEGLPESDPLLKMVFARVGFLQPWRNRSSGYVYGSGSGNRGNGNNGERINDNGKRPRGRDSGGEGMTTEKEMGEEAGDWLHQNPEIVTAVLMEMAARREEDFYQTQYQSPGLQGPPGMGGYMGMGMGMGRMDAGGRSLPSMERPWAAAGAGGGGRPNGTAGGMGDPMGGGGGGGPLPWVNHWDPNRPNTLRPGPMAHHHHWPFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JSF8</accession>
    <name>A0AAE0JSF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_454222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687546.1">
        <property type="nucleotide sequence ID" value="XM_062826186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JSF8"/>
    <dbReference type="GeneID" id="87863340"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3356169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="345" mass="36876" checksum="1FAB42C06A32E21A" modified="2024-05-29" version="1" fragment="single">MVDRARKPSALASTPGLPPQPQVAFSSDNSRVTATLPTGESVSVLLYGATVVSWKDKNGDEKLWLSEAAKLDGSKPVRGGIPLVFPVFGTAPDHAQTKELPQHGFARSSRWEFLGKSTSESTPTPTTPAFAATATSAAGAVAAAAADMSVKLDFGLSSSGLSEDARAKWPYAFNAIYSVTLNTDSLATNLVVTNDDERSWECQVLMHTYLKVDDITSVSIHGLENATYVDKTTTPISTTTQSTPTLTISSEIDRVYTPAGDSPASVPITVWSQDKPKYTILRDNLSNVVVWNPWIEKAQGMADFEPKDGYKNMLCVEPGAVSTWQVLEPGDAFEGAQTIVLGGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJM1</accession>
    <name>A0AAE0MJM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_446680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677162.1">
        <property type="nucleotide sequence ID" value="XM_062825807.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87862961"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="253"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
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            <end position="305"/>
        </location>
    </feature>
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            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3334996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="540" mass="60296" checksum="4C631C8BADDDFA33" modified="2024-05-29" version="1">MAAVAPMDMEETKYDPTLIPLKCTLCPKQPIFSDVSHLLTHCSSKSHLSHRFKTELRSGNDDASRETMQQYLKWEETSGIKELLIERLEAKENKKPAKRGRPAGTANRPKAFQNRDDLVKNEPAGEQLDHTPVLTHWITDPNNASLQFHNLRHGHAYLDPPGFQTPVMKRSRSDFPASDTPDNMFASKYDRWPSETATSDSILPSSEVTSEITEFDDDDDESSKLKGIRYPGMGLFDSANEQQKRKRNQRKDESVLKLMEEASTTIEQKEYIYSEDWTLQRERDVYASPSIYEGSPGRELEEADNHKKKRNRRASTLTNAKPRATRTSARNKTVAKAKSTREETMSIEQDESISQISGHSHGAMESYDVFHDPPQRSPHRSGSPMGSFFDLRHRPALKALPSNGPLPSNGQLGSSGPKPLNGSQLSYFSPRDSMANSYSGLPSNGLSNNGLPSNGFFSSQQHPSYNGLNPLSISGRPSYMQSFNYSGYGSESPRAPNTSAFQPINPMVRSMSTAMPYSSSYASPYPADPALERLPSDFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMC7</accession>
    <name>A0AAE0MMC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_581303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677372.1">
        <property type="nucleotide sequence ID" value="XM_062830812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87867966"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="144"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="874"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1139"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1561"/>
            <end position="2592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1143"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1561"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1626"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1656"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1714"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1725"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1823"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1870"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1908"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1958"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1977"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2032"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2057"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2115"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2137"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2154"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2174"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2212"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2268"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2303"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2376"/>
            <end position="2389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2390"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2426"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2452"/>
            <end position="2462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2484"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2534"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2555"/>
            <end position="2567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3337921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2592" mass="283612" checksum="F7472DAF3CFDF730" modified="2024-05-29" version="1">MPPKRKRSDHRGPPDSGPSRPAPHRPDNTSLGQHDRGYDGGRGGGRNGRNTRRPDRRDSNQPYNSNNNNSNNNNSNNPNPPIPSSASRPPSSSSANNLPPINTAPPTPVPNPSAAAPTPAPPPQPTYPSAPPSPIQPGYDYSIITDDRVSRWSKGARQEVIDHGVQSRDDEDLTEVAAIFQELIHSAVDGRLPGSDAGKVIKDILGPEPSEADRAALVFDAHTLFLDTVATFMDVENAPFRPQLRDLMYATEVSTTLMRQVLDAAVLQPLGLVRDTFVRVGIRQSTNLLYRQANYNLLREETEGYSKLVTELFTTSSAEPPSSEVVQAAFNKVMGLIGTFDLHPGRVLDVTLDVFASVLIKQFRFFIKFLRVSSWWPRTQIKLPPETFVGGLPIWALPDHSNWVASEEEEKALAAQRLKRDIAFWDRARKIKLDAFFELGGRQVTNLDDEDLPDARAESGQENSIQKEWIKITKTLPPTGNRDAAQMLGFKLRFYTTEARDSEDMLPANLLYLLALLIKVGFITLTDLWEHIWPPDDMMEAVKEARFKELEEKERANRPGGAANALMMAGALPDDMAPPPMNSRRDMAHGKADADTKATAETAEEKPKLPEPDDQKVILLKCLLTIGAIPESLFIIGRHDWILQAHPDLIPLVHRILHHSVETVYQQSRPQPKSPASANCPGKKLPDVDQSGVPKGSIRLAAITPKRALRWPFPDAETSEGGGYRFYWDEWADNVPVCQTVDDIFTLCDTFVNVIGVSIGQDAGLIAKLTSIGAKSMADDQSPANRSRWLALLKRLLVPSLSLLETNSSVVDGVWTLLKQFPIHVRYNVYAEWYEGQTSRLEPMKKAFARTRLETLSTMKRLSLTNIPQMAKTLAKTAYPSPGIVCKVALQQIESYSNLIEAFVECAKYFTDLGYDVLVWSVLSSLGGQQRSRTQESSVLLTSKWLQALSRFSGKVFLRYSRMDPTPILRYVDNQLSKGNSTDLVILKELISSMGGVVSDLDFTDAQLHAMTGGELLRRETLTNLGDKRYVSTKSADRLVQALMTNGLAGRLLANIAQYRQSAISAVVQGDAHIKYLATMADDTHQVLLQYLDLLRSSLDGETFNNLVPSVIRLMRDYGLGAGLAFLIGRASIRTAMNRVRGQSESQAPAASAAPDTDGDVAMTTANGDDAASTPAADGQTTVPAQGANERKVDPVLEPFQPVIDEIPTVLSEDTLRYLTPTCYVLFWALQLGDLSFPQDNYSDEINRLKKLAREVMNDRSDMTRIGMNKKTQKQAEINARVSSLLKENSEELQRYSKFRFQLSRQLTTWFPADITKVDVTADTMLEECILPRLQLSGLDAEYSFKFLKFLHEFSAPNFKLMSLYDRLFQHNRLRSMLFTCTVREAEHIGRFLKCILSELSKWHGDKNAYEKEALGSKEVQGKKTRNYVGFATAFDADGKPTAFVEHDAFRDLLFKWHKELNSALRACLNDMEWMHIRNAITVLKAVIDFFPAINFMAEKFLEQLKTITEREAASKNAPETEEGHRVDLSVTAQTAFSELQKRKSKWILVQAFRPGIVSASAQAPTRTNADRAQTGDSKEEGKSSLRAAAATLKPNSHGRKQSAAEVEDGEVKDGRSGRSGAASGNQKDSAPTRNLPTREPQKDANPPQRSMGGNGPPPRPPAPNAGPLPTKLPGNRSDVNRPSTLTSGGRGLPSNPDLPRRPDVPIPEVFSASHFNRAQHNMNNRREPASSRDGRDAREPRETREPRETHPRETREPVHGRESRDYRAPETSRPERPRDFPSTDRRPAEPPTRDSSRPSDRDWPNRAEPPPRRTEPTAAPGRDGRQPRDRTPHGANRHDGRLSRENAGAAPSAVASSHNDAPEPPINPERARLLAEAEQKQSHPNPPRAAEQPPSHINPARAALITDAREPQGRSSSRDQTRERPPRTESPRSSERSATSQADNARDDRQGRHRHSDYHSTGRDGHAHGDIGSSHGRLDRPADREIERPGGSRDGSYTQPPPRGTDHDHGRPVQQDPNYGRLNPIQSIVDSGPAAVPAATSGSGGPPPSGPRGRGRNNARMGPANGVPIRPDGRFPGMEANRTSSPDRQPPTGPSSSRQSRRGQYDNAGGNVNAPPSSLPSQSPGVHPDRMSHINQQPQQGGQSSQQQQSQAGPPPPPPPPPSAPGVHPDRLNQINPDRLNQINGPPSHRPTGPSAHNRPPINTPDRPSMSAPNNSGRQQPSGQHGSNFATPTGPSASNNDRMRSGGGSRQLRGIQNMLDKASMDARGPGSRMRGSSRLNTMVDSDAQVLAGASPGNTPVNDRPDPLRDIRETGSRREMSTDRGDRDRDRGRDTRDRESRDREPRGGLAPIQVVGDSREDSSSIPHGGHSRGDVNGEGYGSSSRGGAGGDHERGSSRHHSSRSERSDRPSRRNSRERNPGGGGGDAKESSSRSDYSRESRSRGGGGGGGPSTANAPGGPSADLITGGSSRGDRRSGRDSNAGSGSGHRGGGGDMPPPPPSREPSHRGHGSHRGGGDGSSHNQGGPPPMGGGRSDGHGRPPRESRSSRPSGPGGGHDDMRGGGDDRSRKRRGDGVIDSSQGPGGHQDKRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNQ2</accession>
    <name>A0AAE0MNQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase cel3A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H65DRAFT_445206</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678306.1">
        <property type="nucleotide sequence ID" value="XM_062825725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNQ2"/>
    <dbReference type="GeneID" id="87862879"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF28">
        <property type="entry name" value="BETA-GLUCOSIDASE L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041978414" description="Beta-glucosidase cel3A" evidence="18">
        <location>
            <begin position="18"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="19">
        <location>
            <begin position="90"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 C-terminal" evidence="20">
        <location>
            <begin position="355"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="21">
        <location>
            <begin position="653"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3338946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="695" mass="73067" checksum="99B1DC7E3B303A2C" modified="2024-05-29" version="1">MHLLIFAVLATSSLAWAETGEKQARQAGSGSAAWDAAYSQASTALSKLSQQDKVNIVTGVGWNKGPCVGNTPAIGSIGYPQLCLQDGPLGIRLAGSVTAFTPGIQAASTWDVELIRQRGIYLGAEAKGVGVHVLLGPVAGPLGKIPNGGRNWEGFGPDPYLTGIAMSETIEGIQSNGVQACAKHFILNEQETNRETISSVVDDRTMHELYLFPFADAVHSNVASVMCSYNKVNGTWACETDKILNGLLKKELGFKGYVMSDWNAQHTTNGAANSGMDMTMPGSDFNGKTILWGPQLNTAVNNGQVSKARLDDMAKRILASWYLLKQNSGYPATNLKANVQGNHKENVRAVARDGIVLLKNDDNILPLKKPSKLAVIGSSSVVNPAGINACADRGCNTGALGMGWGSGTAEYPYFVAPYDALKTRAQSDGTTINLLSSDSTSGVANAASGADAALVFITADSGEGYTTVEGVTGDRPNLDPWHNGNQLVQAVAQANKNTIVVVHSTGPIILETILAQPGVKAVVWAGLPSQENGNALVDVLYGLVSPSGKLPYTIARSESDYGTAVQRGGTDQFAEGLFIDYRHFDKNGIAPRYEFGFGLSYTNFTYSSLSITSTASSGPASGDTIPGGRSDLWETVATVTAVVKNTGGVQGAEVPQLYITLPSSAPSNPPKQLRGFTKLKLAPGETGVVGSQEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNS3</accession>
    <name>A0AAE0MNS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mago nashi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_511830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677330.1">
        <property type="nucleotide sequence ID" value="XM_062828527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNS3"/>
    <dbReference type="GeneID" id="87865681"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3337879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="154" mass="17741" checksum="695B2745BE387045" modified="2024-05-29" version="1">MSAANEPFYLRYYSGHSGRFGHEFLEFDFRVLGDGRSATARYANNSNYRNDSLIRKEMCISSLVIDEIKRIIKDSEILKEDDEKWPTKNKDGKQELEIRIGNDHISFETAKIGSINDVTDSADPEGLRVFYYLVQDLKALVFSLIALHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNT0</accession>
    <name>A0AAE0MNT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_445599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678768.1">
        <property type="nucleotide sequence ID" value="XM_062825754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNT0"/>
    <dbReference type="GeneID" id="87862908"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="232"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="832"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="650"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="762"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="954"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3339408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114447" checksum="A42800C7409DAC39" modified="2024-05-29" version="1">MEHDSLVSVRLSEPSRSSLQIDTTVSPPRKNVWGLDDSPSASPTDEDAETETIKEEKNDEDRNDELKTPASTHSPSLLEELESVQEEDNEEAEDDNDDARSEGSSAESEDVNWDDLQKKEDEQVKEQDADNTQSTAMLLAKLEQENNKIATNPKSVKVAAVEKVTSPGRKPRPPSMAQLRQMVNGPTPPALRYSVLPPPPMTELEFYMALVKDPKQTAARLPTLLSNKIRKGIPPPLRGVVWQSMCGARDKDLEDVFERLSGESSPYEGIIGKDLGRSFPGVEMFRDPEGDGQRMLGRVLKTFSLYDTKIGYCQGLAFLVGPLLMHMPDKHAFCVLVRLMENYDLRHCFVPDLSGLHVRIYQFTELLKQHLPVVADHLEDLGVEPAYVSQWFLSFFAVTCPLPMLFRIYDVIFAEGASETIMRVALSLMRKNEGRILACTEMEDVMQLLLSRGLWDCYHYNADEFVQDFVALSDVVTRERMALLEQGYREAKIPPSANPKSEDAPGSDVATAASRFLGRLWASSSTPKLASFASAVQGSSTASSSSPTTISSGNTLSPGLSRPLSMLRRSTSKSTLNSMEAASQSSSASSSASVLSSASTEATSVQSRDSSTTIDHDSSRDSVALGSSAASTKAKQAHFSVTPSLYQDDRKHLHTQIEDLLTALSELQRNHALLASQLQKEREERDEDRQAVRSLLDGLRKKANPAALSYAAAAREAEEDDETPSKDVEIDLSPEELSDLLDFVADRFSEEDPNKVAIPQTKEQLHEDLVRVREQLSNEQAKTQECNRRIHDMEQEVANMKEQLRETHAHVRNMHAEKQRLERQIHGMRVRASDATPSSEGGDWFGRSSISGSSAPGGGLRELKLVRSKSSPAPPPMYPTKRSSSMMTTSTLVSASTHRQSTSTHRREASNATTISAISSNSPPAPAPVSLAAASPANTGQAPTSENDALLLELVQAKTAEAMAKQEAEEAKQQLERMRKALGLTPGEMPSVNSQSAHNSMAGMFGRLTGPSTPDGGPGLQKVVTSPPGTSAGNTASGASFWGWGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNT3</accession>
    <name>A0AAE0MNT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Elongation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_475201</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678396.1">
        <property type="nucleotide sequence ID" value="XM_062827293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNT3"/>
    <dbReference type="GeneID" id="87864447"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="158"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="401"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="709"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3339036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="778" mass="86834" checksum="1362F47A3BE270CB" modified="2024-05-29" version="1">MCKLVDDPNIVAPFLPKMMPGLQKNYDNLADPEAREKTKQALDTLTRVGNVVDGKIPEAQNPGDVNIVLAHLKEILGSKYASAFDKFAPIVEYVAAVAGQLVDEKATESSIWAEAVKPYLTVIVGDAESEALTDALRKKATPGAAEADEAEADDEEGEDLCNCTFSLAYGAKILLNQTHLRLKRGQRYGLCGPNGSGKSTLMRAINNEQVEGFPKQSEVKTVFVEHDLDSEDTEMTTIDWTMKKLKEAGVDTSREDVEAKLAEFGFSTDMIKNDISALSGGWKMKLALCRAVFEAPDILLLDEPTNHLDVKNVKWLEDYLKSSPCTSIIVSHDSGFLDNVCQHIIHYERFKLKRYRGNLKDFVSRVPSAKSYYELGASEMEFSFPEPGFLEGVKTKAKAILRATKMSFQYPGTAKPQISNISFQCSLGSRIAVIGPNGAGKSTLINVLTGELIPTEGEIYQHENIRIAYIKQHAFAHIDNHLDKTPSEYIQWRFQTGEDRETMDRANKIITEADEEAMNKVFKVEGTARRVIGIHSRRKFKNSYEYECSFALGENIGMKNERWVPMMTADNAWLPRNELLASHQKMVADVDMKEALASGQFRPLVRKEIESHCANFGLDAELVSHSRMRGLSGGQRVKVVLAACSWQRPHLIVLDEPTNYLDRDSLGALSKALKKFEGGVIIITHSAEFTKDLTEEVWAVLDGKMTPSGHNWVQGQGSGPRLKEDDGEEEDKFDAMGNKIVSTKKKAKLSSAELRKKKKERMARRKRGEEVFSDEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPI6</accession>
    <name>A0AAE0MPI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_430956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062824917.1"/>
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    <dbReference type="GeneID" id="87862071"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
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        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L31"/>
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    </dbReference>
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        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="110" mass="13147" checksum="F71F905AC73632CF" modified="2024-05-29" version="1">MFGAFRFTNPLSGGLLWKIPWRMSKFQKLRQRRRLRAVDNVVDTIENALAKKGETVKAVERWRAEMPTEAEMLPKDKYTIFDRKEKRYRKGIHKLPKWTRVSQRVNPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPS7</accession>
    <name>A0AAE0MPS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_431643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679024.1">
        <property type="nucleotide sequence ID" value="XM_062824957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPS7"/>
    <dbReference type="GeneID" id="87862111"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000224">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="317"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
    </feature>
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        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3340082.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPY9</accession>
    <name>A0AAE0MPY9_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
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    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_428539</name>
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    <organism evidence="2 3">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680027.1">
        <property type="nucleotide sequence ID" value="XM_062824770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPY9"/>
    <dbReference type="GeneID" id="87861924"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="256" mass="27872" checksum="13A733B37AD89208" modified="2024-05-29" version="1">MASNPPSKCCTVGFRHDGEPTGSMTKVADKWDAYIAQPSGSQKTGKALLFLPDIIGIWQNSKLMADQLAAQGYLTVVLDIFNGDALPINRPDDFDLMGWMTKGSTGDNPHTKEAVDPIVQAAIKELKEKYGATKIGALGYCFGAKCLVRNMTATAPFTGIDVGFIAHPSFVDEEELAAINGPLAIAAAETDSIFPAEKRHKSEEILKETGFPYNINLYSGVTHGFAMRADLSKKPEKFAREQAFAQAVAWFEEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQK3</accession>
    <name>A0AAE0MQK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligosaccharyl transferase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_232245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680658.1">
        <property type="nucleotide sequence ID" value="XM_062822201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQK3"/>
    <dbReference type="GeneID" id="87859355"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000302">
        <property type="entry name" value="Oligosaccharyl transferase subunit (Gamma), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041991716" description="Oligosaccharyl transferase subunit" evidence="10">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3342865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36688" checksum="CC01D52061320750" modified="2024-05-29" version="1">MRWLPAFLSASLFAAGSFAAKKSSEERFAEFHAKQTSHAPVKLNDASFKSLTAAPRDYSVAVVLTALDARYGCQLCREFQPEWELLSKSWVKGDKSGESRVIFGSLDFGEGRETFMGFGLQTAPVLFFFPPTTGPHAAASPEPIRYDFTNGPVPAEMVHSWLVRHLDGRPHPPVKRPVDYLKWAVSFTMITGSLTAVYVAWPYVVPVIQNRNVWAAFTLIAILLFTSGHMFNQIRKVPYVANNPRGGVSYFAAGFQSQYGLETQIVAALYGLLSFAVISLAVKVPRIADPRSQVITVWAWSGVILLVYSFLLSIFRVKNAGYPFYLPPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQL5</accession>
    <name>A0AAE0MQL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_278399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679939.1">
        <property type="nucleotide sequence ID" value="XM_062822843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQL5"/>
    <dbReference type="GeneID" id="87859997"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="550" mass="63558" checksum="E4F3A4DEA198FEFE" modified="2024-05-29" version="1">MEVDNNNFWGHLPTVLDAIADAEYISLSVIGHPDAITKADQTKEELYRELVEHSKIYHISKIGLTCFQYDEEKKEYSARSFNFAITPWFLSANIQAELIAKTVNRTFSFTYDTLKQLRTHGWDYNEAWERGVPYLTRWEAQTVEERFLQPWESKKPLDINKLDVESQTFRTWANAQITSWLTKEDKTLDLATPSGERFTSLQVGLICQLVHSCFDECRATPKDDNRIMQIKKLSRAELITEKLTSRRTALTQQSGFLYVVEALLGGHFADDIEPELCFFYVSHMDRDSREQLISAFRDRIEAAEYRNRLRRPILLVHGQLDMLCYFYSTFLGPLPETLDEFTKRIHQIFPRIVDTRILYPPDNYPSHSPHKRKSSIEFISAAEEEGGPRATQVRGLEYKDKMAEEHGLYGWYSNLAFLKVAAKKLQKEPWLSKTRPQKTYGSMRMKAKKPSKLFFTLNPFAPDRISRRSSICSSVASGMTGSIDTPPSVFGDGSDEEEEEKHEVPEIHRLPPWEAVFWEKFGNKLILDDGEVLALTAASIPLRKTRVRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQZ7</accession>
    <name>A0AAE0MQZ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2461 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_589573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680329.1">
        <property type="nucleotide sequence ID" value="XM_062831037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQZ7"/>
    <dbReference type="GeneID" id="87868191"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47775" checksum="D25314D454A635B1" modified="2024-05-29" version="1">MPPRKRKAAAIAHDDHDAVSTPDSSRRRSTRVSSSAKKSHYFEGDSESDSPEASAAAKSKAKPTAAKQRQRGRPKKAKVEADPDEDGDEDDEDAYHDEPTETQNDDDKNNNEESEDDDEAASPKVTFIPIPKLRDLNGVAYSPNTIHPNTLHFLRDLRANNKRSWLKLHDAEYRRSLSDWESYAMSLTDLIISSCDPTIPELPFRDVNFRIYRDIRFSKDPTPYKPHYSASWSRTGRKGPYACYYVHVEPGKCFVGGGLWHPDGPALGRLRSSIDERPGRWRKVLMDKTFKETFLGGAGAKEKTGQKGMGKGKKKKGRGKKDEDVEEDDDGLDEERAVIKAFCAANAENALKTKPKGFDAEHRDIELLKLRNFTVGKKLPDSVFTSEGGQEQVLNVIKAMVPFVTHLNRIVMPDPGDEDDSEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRG4</accession>
    <name>A0AAE0MRG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_443214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680165.1">
        <property type="nucleotide sequence ID" value="XM_062825621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRG4"/>
    <dbReference type="GeneID" id="87862775"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="276" mass="29567" checksum="79C6F9D4D7EFBE2F" modified="2024-05-29" version="1">MRSSPASNPLPRGILGWTIGKLVTEGWRAPAHRARLYKAAPIPPIIIEDDDAPGSPNALDVPGSPDVPVATGASAPVPDAASMLFGSLFVARLTALETKIDEMGTAIASSAETRDSNGGAAHDCRLQSKRPAGAIATPGPGKLFSSLANCKGWPNLRRAFWDTLRDAWPQHQPGPPQLRPLLPRPQHREEEFDELPERAPEPFRPMAPPMAPPPIPMAPGHRPLAPAPPRQQAHLPTAATTTTQNNVDKADSRPKTTERTRARFSGTGRAQEANIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSH9</accession>
    <name>A0AAE0MSH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_556949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682607.1">
        <property type="nucleotide sequence ID" value="XM_062830070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSH9"/>
    <dbReference type="GeneID" id="87867224"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042062048" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19833" checksum="A6B9F90C3046568C" modified="2024-05-29" version="1">MVAMKLATIAVLATVAVAAPATTATTTTEAKPFSFSQWVDDIINPDVVALTPEQAVEAYYQSINATTSTHDGTVKAKRVEKHCFNDDLGWRADVDAAVKCVNEVAALGSSVRYTVKPGVEVCRDIPGVKIKVDPGYPDTWEVTAQQLAIAGGHIMDACTWGGRTGGMIFEEWNRWMEIDLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSN3</accession>
    <name>A0AAE0MSN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_206204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682054.1">
        <property type="nucleotide sequence ID" value="XM_062821868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSN3"/>
    <dbReference type="GeneID" id="87859022"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="136" mass="15644" checksum="A88FA81B6195AC8B" modified="2024-05-29" version="1">MTRERGNSKFGNIGEDRCPRYEIWQVWSCRLSFIRQQHRRRLRSSSSCCTVIVAEVPGRANSITSSCPAASQTQSNSQCHGNRNPSLAFGERSDREPSEACHPEWRHGANWMQARRWSRNGLVKLSHVHPELVHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSX9</accession>
    <name>A0AAE0MSX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">X-domain of DnaJ-containing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_422770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683072.1">
        <property type="nucleotide sequence ID" value="XM_062824419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSX9"/>
    <dbReference type="GeneID" id="87861573"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="515" mass="56710" checksum="611BEF654E719DB0" modified="2024-05-29" version="1">MVVDTAYYDVLNVKPTATELEIKKAYRKLAIVHHPDKNPDDPTAHERFQQIGEAYQVLSDSDLRAAYDKYGKESARPTEGFVDPAEFFTSIFGGEAFVDWIGEISLMKDLTATMEISMAEMEAEEAAAAAEGGEFPGTDEAVKESLKTAAGATPADASTSAPPKVVVEDEASAAPAAAPKVPSPSPSPAPPSGTSTPRSGSRMQIPIRPALMDRPADEVLAGTEESNTDVNKKGKDKKKGGLSKEQREQLAAYEKERARIREERVNTLAQKLLDRISIWTETDKGKDVTHSFQEKMRLEVEELKMESFGLDILHAIGQTYVSKATALLRSQKFFGMGGFLSRMKDKGTMVKDTWNTISSAIDAQQSMEEMARMEQLGGEDWTEEKKMEYERRVTGKILTAAWRGSKFEIQSVLRDVCDAVLQDKKIPLAKRLERAEALVIIGEICSKAKRSPEEEGDYMAFEQLVAEANLKKEKESKKKDKEKKKHRHSSDKGSTHSAQAAATAADVPNVPKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTM5</accession>
    <name>A0AAE0MTM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_455094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683837.1">
        <property type="nucleotide sequence ID" value="XM_062826222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTM5"/>
    <dbReference type="GeneID" id="87863376"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3350542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="125" mass="14175" checksum="76D8923DEC296B07" modified="2024-05-29" version="1">MLFFPTLSCFRDELCSTGLRGTSRCLGSRLKVSGDFLIRSNVFFVLPKSACVWEELLLTVLVAGFRSLLSIARCKRIMASIFSKSYSPLLLPSRPMMTTQLAFPSRVQRLHSPRLSRLHETKKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTZ9</accession>
    <name>A0AAE0MTZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_419117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684242.1">
        <property type="nucleotide sequence ID" value="XM_062824184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTZ9"/>
    <dbReference type="GeneID" id="87861338"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3350947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="329" mass="37688" checksum="3E1FA9DE6EFBEE23" modified="2024-05-29" version="1">MASPAETSVTYEELRDLENEFEDVETEIIRQQVQLSRPLYEKREKVVAQIPNFWPLVFEQAPQDIDEYIQPQDSALLLSSLTSFSVSHFEIENGGSGDPRSVLFRFEFAENEYFEDKVLEKKFWSRRSKGGWTGLVSEPVNIKWKKGKDLTSGLLGLVNAVWEEEKAAGKHWSTVKGDDFTDKQKELRDQIEKIGLGGLSFFAWFGYRGRRVSAEENKAAIEKLQEKRQARKAAAEVGESKKEEEEEDDEEEEEEEDEIELEIFPDGDSLALALSDDLWPGAIKYFTQAQEQELASDDDFEDDDDEDAGEDDEEDDADARPAKKRKAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU35</accession>
    <name>A0AAE0MU35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_422658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682880.1">
        <property type="nucleotide sequence ID" value="XM_062824412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU35"/>
    <dbReference type="GeneID" id="87861566"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06409">
        <property type="entry name" value="PB1_MUG70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="339"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="482"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3347798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1130" mass="122665" checksum="57DD5D3450076AEB" modified="2024-05-29" version="1">MSTNPARGPSRAGGSSAQQQNRSATPYGQNHAGSAIPRPVLEANHAATGSEVGSASFSVSRQKQSKRDEAIRRKMESDLSKKKHLTSRARHTRKAPPGTVLALKPSPALQIKAATTVSEAAQLMAAKREDCVLVTDDDERIAGIFTAKDLAFRVVGGGLKANTVTIAEIMTKNPLCARTDTSATDALDLMVRKGFRHLPVMDENQDISGILDITKCFYDAMEKLERAYASSRRLYDALEGVQSELGASQPQQIIQYVEALRSKMSGPTLESVLNGIPPTTVSVRTSVKEAAQLMKENHTTAVLVQDQGAITGIFTSKDVVLRVIAPGLDPATCSVVRVMTPHPDFAPMDMTIQAALRKMHDGHYLNLPVMNDTGEIVGMVDVLKLTYATLEQINTMGSGSDNEGPAWNKFWLSLDHETESMVSGDGSHHHTHHGPRSLMSPDMARSERIVDSVAPGDSASHAGIESPSHSQLGGIQEVNPADIPFPFKFKAPSGRVHRLQVTASHGMAEFVAAVAAKLGAEVDAIGGTPEVENGRLSGGFALSYLDDEGDSVSITTDPDLLEAILLARHGLREKVDLFVHDPSEPAISHAPTPAPVIETIPATPPASSVVRERRKKVEEESEEVSEEEEEPVRRRPTRMRTMSQPQQEPAQVIAGVPNELLLPGAIVTLAVVIVSVFTITRLTSPADLQRLPDDDVSDPSISTMIVRNIGARLGRRALATPLSRASFQAQSRFLSQDNFTAPPPPTNTKKQAAETAFAEPTLEEQADFYAESIEKLTPEFAASPAAEAWSATSATATETVTTWDPSLVDEEALKLKQQIEAIPGNFKLFKQTKAQTQKLGAGVEVRYIPEQYLRNPPSDASLEDLMAAQAHMGHNTSLWNPANARYIYGVRQGIHIISLETTATHLRRAARVVEEVAYRGGLILFVGTRPGQRPIVVRAAELARACHLFTKWRPGTITNREQLLGGVPLTVVDELDRPLSGFEDHLHDRRPLAPDLVVCLNPKENMTLLYECSLAKVPTIGIIDTNTNPAWVTYQIPANDDSLRATALISGVLGRAGERGQKRRLEAAQRGEVTWKTPADVQGYFELASARAADVRRRQAQDNSVEEQKEKDTFLSEDALKEMFGGGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUE7</accession>
    <name>A0AAE0MUE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_568519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684692.1">
        <property type="nucleotide sequence ID" value="XM_062830396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUE7"/>
    <dbReference type="GeneID" id="87867550"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="56112" checksum="F81B51EBD58E65B4" modified="2024-05-29" version="1">MFITKSHLRRITSHNTSHLTTPHLLLSEISGSLGDLGTLLPLLLALSLQGSIDLPSTLIFSGLFNIATGFIFGVPLPVQPMKAIAAASLASSPSPGLGTTVAAGAWVGFAVLLLGGTGGLKRVMRWVPGAVVRGVQVGAGLSLVVAAGGGMVRPLGWWWTPEEENGHGDGDGGIGRWLDSRAWAVLAFGGLVVTLGQQQQSGPKGRRRMPVPYALVLFLVGLVFAVVRVSLSKDSPDQPPPYDEPTNSYSWTWIWNPLHHIHPEVFHSLLNPQALSMALAQLPLTTLNSIIAASALASDLFPRSSYPQLYDDEPSSNPAASNPPASDLASSDPSPSSSSSSSSSHSSSSSTSSPKSSSSSKEGPVPLTPLSLSISLMNLLSAPFGCMPLCHGSGGLAAQHRFGARSGTSIIFLGTLKFLLGLFFSSGTTGLLLRILEKFPRAFLGVMVLGAGVELGRVGVRSVEGGEEEDRMVMLMTAGTILAFRNDGVGFLAGMGCYGGYRVAGWLGGGKEIGREEERGLLNDEGVVDEESPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUH2</accession>
    <name>A0AAE0MUH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_104721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684246.1">
        <property type="nucleotide sequence ID" value="XM_062820473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUH2"/>
    <dbReference type="GeneID" id="87857627"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="394" mass="41179" checksum="53F11FD917A5F06B" modified="2024-05-29" version="1">MGLNKTHEMPPPGASLPIIDVEKAASEDARTRLTRPEDQRLPSNTTDNNKMTSSRRALLSVTLCLLFFFGLTSARPSRWQQRVQCHEGAASAEGENFQSMVDAASPDSLHIILHKTFPGRFQHGVWESEKQAIEAVRRDNAPLATAILRMAKRDDSNTTIASSTQQPTQQPTPSSASSSAQVTSSSSSAAQVTSSSSSAPAPEPSTTTQAPPVITTTSTTSTKSTSSSVPQASPSSTGTSVGESERTLVPLSTSSSASSVSSSEPSSEAGVSSTTSSSSVSSTTLTTTSKAKPQTTEQPQTTQQPQQPDEPMTPSSKVIVQTLTSTSDGVEIVVTQTSTVRVDPTPTVGAATTRASPSLQNAGSSIQQQRGAGRWLMVVEAVVLGALLIFFVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUJ8</accession>
    <name>A0AAE0MUJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_440461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684888.1">
        <property type="nucleotide sequence ID" value="XM_062825477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUJ8"/>
    <dbReference type="SMR" id="A0AAE0MUJ8"/>
    <dbReference type="GeneID" id="87862631"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000015">
        <property type="entry name" value="30S ribosomal protein-like protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="119" mass="13479" checksum="A1DFC953E03FE93A" modified="2024-05-29" version="1">MVFILGVNFNEHKLVQKALESFYGLGQQASARILAKYSIHPRAKMGTLPPKIVTALTAELSTMTIENDARRLVLDNIKRLRDMGTYRGRRHAMGLPVRGQQTRNQIANARKLNKIERHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVP4</accession>
    <name>A0AAE0MVP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_20094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686043.1">
        <property type="nucleotide sequence ID" value="XM_062821783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVP4"/>
    <dbReference type="GeneID" id="87858937"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="224" mass="23985" checksum="FF0A7D32F35D6E68" modified="2024-05-29" version="1">MSCPAEHGQRLKAISTSPNIYRLSGETLPCRLLIAVEAQESRSNTSHLRHLLLCDDAVHPSRKGITSSGLTGFSLRMAGHATTDVTTPLIVQMPSSRTPSVSTPPQKSHAPIVPDLMPISGAVLCTSTFGVAGPGMGPVHGPRMPYSIVTYCVSYGLRLPTPFCTTHLHRGTPTHVKHRTAYLAMPRGRMALCFLPPHRTSRAAVSRTADGKPFPHAQVAACIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW10</accession>
    <name>A0AAE0MW10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_126971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684905.1">
        <property type="nucleotide sequence ID" value="XM_062820758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW10"/>
    <dbReference type="GeneID" id="87857912"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="220"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="222"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="566"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="723" mass="78238" checksum="F09820F2CD338CC6" modified="2024-05-29" version="1">MLATSRKGATEQSPWSISKFGTPYSKSADSLRMSNFDPVTQSDWHGQYSFLPPGDNNLFSHSYEHVSGSTDNANSQAQPRSVVGPGNPLEVEPPKRVTSPLGHRADPLGLRQPKQSSPAVEQVESHSEQYTQKAAEAAHEESHTSTETPNISLGSHPLSSVSSAAHGPTSSTAQSMNEVQSTIKEEDDDVLDDEEMIDGDVEGEPQGQAQPQTAAERTAQRRKMKRFRLTHQQTRFLMSEFAKQPHPDAAHRERLSREIPGLSPRQVQVWFQNRRAKIKRLTADERDRVMKMRAVPDDFDNVQALHAPYGAVHGLGTPLTSPVDFAASSYADHMMRPLMVDVRRSDTDDHLSPTGLSPAFGSIGFNPSNSLNNPDILSPMSPPSTDRYGYSNHLSAPLSAGARSSNPFARQPGLDTSVHMHNHHSRHQIRPLHPLQLRETMNRSRADTLQSPLRTSMSWKGDSLDYTTYHGSNTSPPMGSRPQSLYHQDHMNSTSTAGLGSYDSTHYAGSTVQSPTHLSYPNYQSSSLQNNSQRNSRLRASSASLPLGLDLRMQFRSAVGASSLQSTAHSPTSTRTPSTSQLGSGGVSSSYSASSFPSAPLSAPVDYSLPRTSPYRPPPPTGTTDYSIPQMSAPIAPPNDFSQAFQASMSSGGGSSRNTQPLRDNFGGSALGLGHGHNNPASHRTTDDYSAHDPLGMKRKRSYSGTVPAVSSAQGTGAYGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW40</accession>
    <name>A0AAE0MW40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_504501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685789.1">
        <property type="nucleotide sequence ID" value="XM_062827923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW40"/>
    <dbReference type="GeneID" id="87865077"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3354411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="564" mass="63852" checksum="E095BB5923249466" modified="2024-05-29" version="1">MTFNLFDSILISLALILPICYYLLAHRIVYPQPLPGIPYNQTASHRILGDIPDLVTSVRRTKETSSWCFSQCRRLKSPLFLRPFSKPFVFVDDARETEDMLLRRTREFDRAPSTAAFFRTVLPRASIVKPTDHEFKAQRRLWVDVMSPAFLRSVVAPNIYRSTLELVELWRLKSRVGGGGRPFEAHHDLETAAFDAIWVAVLGSELGGIRSEIEAILQTQQEYDDQGKPAHMPVAERSDLYEAIQYLNKSVERIMASPMPVLHHWLIRQTPTYRRYEAIKNKEIRRILKSAYARFKALELSSNLDSHSQEEANEQHQHDTCAMDLILRREMISSERRGTILPPPEENLEMQDELLMLLVAGHETTANTLSWFVKFMAHHPSSQDRLRQHLRAAFPSSNASSPPSAAEILSSTTCIPYLDATIAETNRLAATVPLIVRVTTVDTHILGFAVPKGTHVMCNSRVTEPYDDMDDSVNEEIGGEEVFDPGSLPVLAFSAGPRGCFGEKPPLPTTLTGRRLAMQELRMMIVLLTLSFRFLPLPESLSGMEGQQKVLRSPQQCHVKVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWR3</accession>
    <name>A0AAE0MWR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2 superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_56136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687093.1">
        <property type="nucleotide sequence ID" value="XM_062830169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWR3"/>
    <dbReference type="GeneID" id="87867323"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="267"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="439" mass="50068" checksum="C4C63F66C952C58B" modified="2024-05-29" version="1">MAIGAILEPGIVVGLLAGGTLVNRNTTYTSSTASSRRASWHPLDQTDPEAQPSASLLNDEHNFEGGRKAKVDEDEYAGDSRRPWSPSRSSSSSTVVENQAAEKSLPYGKRFRTLKFMGWEREVVTPDTEIHRDRLLSRVLRKFPFLVEVWYWALIYWVYQLGRAFTAVTLKASTVDAAREHALQIIHMEQRLRIFVEPIFQGWFLGHPTILKWTNRTYSFIHIPGTILFLIVLFYVTTTRPRARIHENHGGGALVRDWRNFVNHFGPDVYERRRRTMAMCNLLAFIVFTFWPCMPPRLLSDPTYNGEDAKEAKSYGFVDTVHGKDGDSSVWTTNKFCNQYAAMPSLHFGYSFLVGLTIATVPLRRQGRFGWKRLVAIFTGMIYPGIILTAIVATANHFILDAVAGACACLIAWKFNHVLLNLLPIEDWFLHFLRMHKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWS4</accession>
    <name>A0AAE0MWS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_554652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686524.1">
        <property type="nucleotide sequence ID" value="XM_062830006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWS4"/>
    <dbReference type="GeneID" id="87867160"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="12"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3355146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="715" mass="76281" checksum="457D898CE3BFF764" modified="2024-05-29" version="1">MRGIQVAQYVKGPQELKVTDLPDPAPASDEYLIEVHAAATNFFDILQIQGKYQHQPPFPWVSGAEFAGVVLATPSGSKNPKFPVGSRVFGASQGAYATKVKAKETTLLPAPEGWSLVDAAGLFVTAPTSYGALVVRAGVKKGDCVLVHAAAGGVGLAAVQIAKAFGATVIATAGTKHKLEVAKSFGADHVVDYADPKWPEVVKKLTPKGKGVDIVYDPVGLVDLSTKCTAWNGRILIVGFAAGKIEKVAMNKVLLKNISLVGIHWGQYAVHEKETVVAVWQGIMKLIAEGKFKPTVFSDKEFVGLEKIPDALIALGGRETWGKVVVQVPQQEGKSRLETPPTAKLFSSTFRRTLRSSASGLTVAAAATAFKKNTTVQPAELQAITKRNMHSKVVIIGSGPAAHTAAVYLGRAELKPVLYEGFMANGIAAGGQLTTTTEIENFPGFPDGIMGQELMDRMKAQSERFGTTIVSETVAKVDLSARPFKYATEWSPEEYHTADAIILATGASARRLHLPGEEKYWQNGISACAVCDGAVPIFRNKHLVVIGGGDSAAEEAMYLTKYGSHVTVLVRKDKLRASHIMAHRLLNHEKVTVRFNTVGVEVKGDEKGLMSHLVVKDVTTGKEETLEANGLFYAIGHDPATALVKGQLETDADGYVVTKPGTTLTSVEGVFAAGDVQDKRYRQAITSAGTGCMAALDAEKFLSEHEETPAVQGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWY0</accession>
    <name>A0AAE0MWY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_451613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686704.1">
        <property type="nucleotide sequence ID" value="XM_062826062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWY0"/>
    <dbReference type="GeneID" id="87863216"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000023">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3355326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="659" mass="71050" checksum="D81E9CEF00AB4588" modified="2024-05-29" version="1">MLDTFEILTTSGVVLWSRTYAAVSPAVVNNFISDVFIEEKSAVAGTKDGASASANPPYKYDQHTLRWSFEKELGIIFVAVYRSLLHLSWIDKLVDNIRTIFVNLYGDQLKKPNVTLIQCARFDNYFDQQLQELEKTGSKSDSKDVRAFQNEPLSDDLSDMPPPLPGLVRGGRVPSNSNTSKQGDSDFDTSPNASRPTTPAVASHLLVAKPGPGGKMSRRARKLQNTNSAPASSGDEASAKRAKAKAAKKGRKWDADGLADEEDDVQLDFSTSKATSDSEGEAGRRPAVEEVDASTWGSTTKGKFVLRDLGDEVHSILASAEAKNSASKTDAPTGLVGTGLSAIGGLFRNVVGGKVLTKEDLDKAMKGMEEHLLKKNVAREAAVRLCEGVEKELIGVKTGSFESINTRIQKAMEVSLTKMLTPTSSLDLLREIDSITSPPATSLRKARPYVMSIVGVNGVGKSTNLSKICFFLLQNKYKVLIAAGDTFRSGAVEQLAVHVRNLKELTQREGGKVELYQKGYGKDAAAVAKDAVAFAAQEGFDVVLIDTAGRRHNDQRLMSSLEKFAKFAQPDKILMVGEALVGTDSVAQAKNFNASFGAGRTLDGFIISKCDTVGDMVGTIVSIVHATNVPVLFVGVGQHYSDLRNFSVKWAVEKLLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX04</accession>
    <name>A0AAE0MX04_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_516263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686794.1">
        <property type="nucleotide sequence ID" value="XM_062828664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX04"/>
    <dbReference type="GeneID" id="87865818"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="518" mass="56089" checksum="8FC8C5BDBD17D039" modified="2024-05-29" version="1">MTTEHLLWIGGSERAGNGELIPVENPATGEIIAHCHSASQEDVVSAVELAHATYKSGVWSRAPRHVRAEVLERAASLFETHLAALIEIEVEQTGRAIREMNAQVPSLVKWFRYYAALLRTGERSVLPTVGKLHNFLDRRPLGVVVQITPFNHPLLIAVKKLAPALAAGNSVLLKPSELTPITSLMLGKIMKEAGLPDGVLSVLPGYGATTGKALVEHPLVKKVDVTGGTAAGRAIGEIVGRNLAKYTAELGGKAPLVVFKDADLDAAVNGIAFGAFIASGQTCVAATRIIVHESIYDGVLQRLKTRATSIERRMGSPKNPECMMGPLISERQLKNVEELVDEAYLYHERIIQVGGNRLEGQSELDDTDFSKGYYFPPTILAYSKPTDRSILNARIWREEAFGPVVVVVGFSTEEEAIELANDSEFGLGAAIWTRDLAQAFRVSEQIDAGIVWVNTHHRNDPSSPWGGAKSQSGVGSENGIDAYHAYTTTKSTIINYASAEEMAAEDWFKEGAGNVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX19</accession>
    <name>A0AAE0MX19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_50171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686886.1">
        <property type="nucleotide sequence ID" value="XM_062827845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MX19"/>
    <dbReference type="GeneID" id="87864999"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000007">
        <property type="entry name" value="Homocysteine S-methyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3355508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="356" mass="39241" checksum="2CB7A0054E2DE3EA" modified="2024-05-29" version="1">MATPIPVQILDGGLGTTLEDLHDITFSFETPLWSSHLLVSGEEDKLLDCHEAFKKAGANIISTATYQASINGFAATKCSSNQVDGIDKEGIPRFLNRAVVLAANAAGREGNVALSLGPYGATMIPSTEYSGKYDPEHQDVRSLEKWHKERLDLFKDVDTKQVNYIAFETVPRLDEIVAIRNLLSVDKIPTSLRERPVWISPLYPNDDEKLPDGSTVEEVVKAVLIHKEGLETPWGIGINCTKVEKLDSLVKRYEDAIQTCIDNGEPMDWPSLVLYPDGANGEVYNTASKTWELPPGHKQPEAPWEATLANVVEAARQRGKWKSIIVGGCCKASPEHIRKLRKTLQDCGYMPTTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MX39</accession>
    <name>A0AAE0MX39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_437992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <source>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="nucleotide sequence ID" value="XM_062830062.1"/>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Mondo S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Ohm R."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3356181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112528" checksum="4D14266AD0A1F2D0" modified="2024-05-29" version="1">MAVPNVDNHVDPVTKPLPPSPSTLPISAIHTPFDPNGNPLPLLSVSDEAQPLHHVLEDPTVIEEEDLSSSPTVAVVDVGRPNQWNTLDTIHDFQDAVAHHQALDSSNYVYREATATPCEPPASKPSKPNRPFQKWIKTLHKRAVRRQEAMGNEHASTSYYFNLDGAGSTAWGPGHHRQSSSTSSFGFVTAVKSASISLTSASTILTRSRRNTVRSSRGQSRTERSSRASLSGARLSEDSYCPERQLVADPAAIGRSLQRRRVLEELVNTEESYIGDVRFLMNVYVTILASLPTLPASLRSSINRNLNDIVELHEEMLGDLHRAIPHSEYTQLNFPLQIPSAGSGFRGHQRWRSLDAVPEDKDGISWLRQVPGMLADPQVAAEVAKIFTKKMNRFFIYEEYGAKYELMIKDVASAHRTMPAWQSYQKGIEILASSLGSANSQDDKERKSLTIGDLLMKPIQRVCKYPLLFAELLKHTPEADCPYSHMEIENSLIRLREATAEINKATDDFKIKSTLEKTWILQDRLVFPNQQLDAASKNRIRSFGHIQLCGALHACWQTKEGVNGQYMVALLYKEWFCLATASRTDQIYTIQACIALSNVKLEEVDNGRGLQCHTAPYSWKLVFLCDHQLYEIILTACTPKEETEWRTRLGSQQTTEGQDQMQPVTFSSLSLNIKTLGAVFRKPGTIARKISIHRATTVGPKSPLCQVILKNTSVIKDAPASGTSSSISRSQSLLTTNTRLPVLAPSREERARLEALLSDVWTRDILPFPGITARSRSEQLVRASASSMMRKLSVVNITNSFTKRSASLTSLPRKGGSGSNGTEDETLVGSTPTKGTTSPKALSRVCYKSEETSRSLLSVIPDKIERRSPMLRSASDSVGKEMLSVVRRSDPVRVRSESETEGTRMVPNDFSGILQHLSGNSSRAPSIQQSNLSKQSTREMSVKRGKENNGSAADSASVRGSGNSTSSGDSEYKASTPRRPRLRKRSKTSTSSGAGNKWAKVNVHREVVVQSLRNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J074</accession>
    <name>A0AAE0J074_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_592856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676692.1">
        <property type="nucleotide sequence ID" value="XM_062831133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J074"/>
    <dbReference type="GeneID" id="87868287"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="236" mass="26931" checksum="74D770E30DF58D38" modified="2024-05-29" version="1">MDKLPQEAVDAIAAYLFPFLAAEREANSVWFSFGDSPQRRNSFSAGPYATISASWQRAVESLTFHKLTLLTRADVFYAEECLRGNTHRRSRVFYIRYDINIEWSARTAHLYTWRDHQIAYEFRKMIEFINRLWPATTDPALPVSPLGLLVNLAGMNQWGDVNEDLERGLTEAPSRMKELPACPAVTSLDIMYEKNTNTRGVWRPGVDTYHGIGTTSVRPTWLVEIAPKFPSLRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0T5</accession>
    <name>A0AAE0J0T5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_480194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677033.1">
        <property type="nucleotide sequence ID" value="XM_062827564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0T5"/>
    <dbReference type="GeneID" id="87864718"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="245" mass="26730" checksum="8BF7A84C1D2E451D" modified="2024-05-29" version="1">MSSSAAESLPITPQAFAAALEDLPVSALHLKVLEIYNSIAHLKYSNEQLRPFAEGLEAPLGGSSSQNQQPDPDCVEAIRENEQVMVRMEERVQLVRNEVERRGLSWTEFERKEEVEAAAARNRARGPVETGEEDSDDEEEQGQQPMTNGTSTTTTTTQQHPAWMDGTFQTGVIRNGEIVMDDVAGSRRQQQEQQGDTGTGTGTGAGAGAGAGGSLSDEELRRRMEERLRDLGGEDDEEEEGGMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0Z9</accession>
    <name>A0AAE0J0Z9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_436873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676708.1">
        <property type="nucleotide sequence ID" value="XM_062825267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0Z9"/>
    <dbReference type="GeneID" id="87862421"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="93"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="377" mass="42760" checksum="161876A442546B2D" modified="2024-05-29" version="1">MYEDDRARRRSFPSLGRKRSNSALSSPTTLTTPSEVKSAQYRDSRFQPLLETKGVFMDKSEDGITVESKTCYMALLTSEQTIPTESLFRDELFEETCRNAANRNEARVVRDILPLIVPPAEILAANGSAGLKCLVESINEGWSSSIPLTGIPRPQPDYSVGFRQKAFTNDQLTKLKPFVGDPLADDQSFFMATKYMYFPFLTCEVKCRLASSDLDVADCQNAHSMALAAQGIVKLFRNVGRENEVHRQIVSFSVSHDHHWVRIYGYYPVIDGKDIKYYRHPIHEFSFTAMDGKEKWTAYRFVKNIYDNWMPDHFKRICSAIDQLPNLDLEVQALSKSNGLSQDLGIQVELSEADSESLRMDKVTIPAPAKRRKEQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1K2</accession>
    <name>A0AAE0J1K2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_480161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677023.1">
        <property type="nucleotide sequence ID" value="XM_062827563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1K2"/>
    <dbReference type="GeneID" id="87864717"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="70" mass="8151" checksum="533370BB5CF8B682" modified="2024-05-29" version="1">MLVIDDFVFFLHSFFIFFCWHNTCLLSVGVRLACLVYDLMYTRCGWVGIGILTDEHKEGNKRNETNVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6U0</accession>
    <name>A0AAE0J6U0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_552468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677409.1">
        <property type="nucleotide sequence ID" value="XM_062829893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6U0"/>
    <dbReference type="GeneID" id="87867047"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="642"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3337958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="739" mass="78553" checksum="01C93054EA02D485" modified="2024-05-29" version="1">MASLLRQIVAGPRLKHEDTGLDLCYVTSNIIATSGPSQTYPQRAYRNPLDRLVAFLDEKHGDGWSIWEFRAEGTGYPDEAVYNRIRHYPWPDHHPPPFRLVPMITASMRNWLDGEDEGTSGNDGDNTTPATPDATNGGAGTGATNGSVKDNEKKEENKNTAEHNKLDLDRPRQKGERVVVVHCKAGKGRSGTSICSYLISECGWTAADALARFTERRMRPNFGKGVSIPSQVRYVGYVDRWANAGSEPTKKKIYVDRPIEIVEIHVWGLRHGVKLAVEGFADEGKRIETLHTFGKGERIVVQGDAPGGGGVMDMFYDMAGYGVGKESDSEEEVEKKGVSGLDGTRSDVDDAADRSTTTDSSSTRRSRSKEKVGKMGSRASSLMRKISVRKGKDHKEKELEKKKSALSGSSATSSDGSIPKLGETTAGNNKAGKAGKANGGKAKTIAMPEASQVTKIPSTEQNTVSESTSNLTPIRSKTSTESAPKQQKPVLAEESEPGGQAVIFKPKNPIIVPNSDINIDIERRSRASASLGLTMVTSVGHVWFNAFFEGNGPEQDGKADESGVFEIEWDKLDGIKGSSRKGTRALDRLSVVWRVAGTGTGAGAATEAAAAVAKGGEQTTAGAAASAAAAPETVQGVTVITQPGEKSPVPQMKPADWKGVGPDHLPKEKELGLRAETTESASVSKASSLRDLDMAEGGPGLEANGKGGGDNDDESLAGVKTSDPKGEELGEVVTPKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7M4</accession>
    <name>A0AAE0J7M4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">B0H65DRAFT_542486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7M4"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="265" mass="28289" checksum="53A0542FF11AD8D0" modified="2024-05-29" version="1">MDKYLDTRFERVEKALSTFIDSIAKYNPSEKLAEDLVAADRELAAGLKELERHQNNHARILQLRQETASLDQQTKDIIGGLWNMRKEVKTTPATQYPATGPKYKFTTHELLNYAKRISRTTLPPAHLLYNGEPLSESQQAPGAGGGQPMEVDSAAQTPMPGGGGGGGGTATAAGTPAASAAPTPAAYGPSALTTTTTAPFSQPPPPPSANQTALPDDFKPHINLLTGYQFHPWPTEDKVRMGGMAAYQSLVSRAVDPRGLALQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7R8</accession>
    <name>A0AAE0J7R8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair protein rad5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_312826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677566.1">
        <property type="nucleotide sequence ID" value="XM_062823324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7R8"/>
    <dbReference type="GeneID" id="87860478"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3338115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="98" mass="10587" checksum="8CD449A46B9DEACA" modified="2024-05-29" version="1">MSVGTGAVGLNLTAASHVHVVEPHWNPSVEAQAIARAIRMGQTKNVIVTRYIMKGTVEENIVALQTKKQTLAKLTFDTGDGVNENLEDFKTVLGVKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7W7</accession>
    <name>A0AAE0J7W7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_325185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677965.1">
        <property type="nucleotide sequence ID" value="XM_062823458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7W7"/>
    <dbReference type="GeneID" id="87860612"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="513" mass="57194" checksum="B391418264BEE07C" modified="2024-05-29" version="1">MIFAVLLALSLSRFFAFSPSLLLSLSLLVSTSGRYCSVFLLSPIFGTRNLAQPFPHVHITKPNEQRTVAITVGLSPTPQGPMAPTLYYTRDTPAFAGFKPEPAGRGTKGIIWTCLSTILLSSWSSFHGPAYDPNESFKSEARDSYIVRFGAAFLLPELVAVRSLRTLYNALQLRKTIRQVGGPEFANFSLTQAFLFINKSVYQRLPNSEKMELVDGKTLVQLMSSRHLPISGLPTDNEIADKSKRDWTLKSLSIIQTLWFIVSVVARLSRGYPVSLFEDITVANAICGVIEFACWFHCPQDIRLPFIVKPDIPRAANGPSTAAEREEPEEEATVEALLLVSEDATKYEASSGPQLSVLVDISTDRPNKEFPSSEQPPLTQKTMKRRVSFATQPAEFRAASNSLFSSILAVFSVLFAGIHMAVWNYSFLSVAEAWIWRGSSLALIVLGLCISLISNQIDERSELETAWDWIFLINTFLYPLARTMMLGVALASFRKVPARLYETPSWTQYWPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J7Z4</accession>
    <name>A0AAE0J7Z4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_433472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678068.1">
        <property type="nucleotide sequence ID" value="XM_062825072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J7Z4"/>
    <dbReference type="GeneID" id="87862226"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="78"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="178" mass="19762" checksum="42C095441C85DE45" modified="2024-05-29" version="1" fragment="single">MDARGPETAAQLRFWLWKCVNDHPKCRMALSGKRFGMHSHTSSLDQTKLPSRILDVGSADSSVVRLVKTTTETPSGSYVALSHCWGPPDKQPLKTTCDTLEDYIRHGIPLACLPQTFADAVWVTRVLGIRYLWIDSLCIIQDSLSDWEVESQKMGPIYEGATLTLGAAYARDSSEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8Y5</accession>
    <name>A0AAE0J8Y5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_292872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678549.1">
        <property type="nucleotide sequence ID" value="XM_062823034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860188"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000542">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000804">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001688">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="893"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="974"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1469"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1472"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1492"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3339189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1564" mass="175440" checksum="332AC5EDA9B3B81B" modified="2024-05-29" version="1">MGQGFSLTAPPAGAAGIDVPELADLTYEKVIGQARFMKSIRARHNDGVVLVKVLVKPYAMSLVRYKKKIIRERNALANVPNALPYQRAIETETNGYLVRQFFYNSLYDRLSTRPFLEDMEKRWLAFQLLCALRDCHAKEIYHGDIKTENTLVTSWNWLYISDFSSSFKPVMLPEDNPADFSYFFDTSGRRTCYLAPERFLPPGQEPDPNAKITWAMDVFSAGCVIAELFLETPIFNLSQLYKYRRGEYDPSISHLSRIPDKDLREMIAHMIQVDPQKRYSAEQYLEFWKDKVFPGYFYNFLHQYMQSITDLSTGNSRTGEADQRIERVWNDFDKISYFLGYENGDDPYEDHLPSPRLGLGLFPVRLNIPNAEHYVSANKQPTIDDGTLIFLTLVASSLRNTAHATAKIKACDIMLAFAERLTDEAKLDRVLPYLMTLLTDKCDRVAISALRTLTQLLDLVKIITPVNSHIFLEYILPRMQVALLGSQDAPSPVVRATYAACLGKLATTAYRFLAMAATLRADGSVTISDPELEPGNETNTALDGLFDSSRQDLVDLFETHTKMLIEDLNPFVRRAFLSSVPDLCIFFGVAKANDVIIAHLNTYLNDRDWMLRYAFFDTVVGISAFMGSSTLESFILPLIIQAVDDPEEFVVQGALQSLAELTRLGLLTKEAFVDLVALVGRFTMHPNLWIREAAAHFIAAGNEFLSPAYLKVSVYPQIKPFLKPDIIPGWSELQLLDSLQKSLSRNVFELAIQWATKSEKSGFWKPPKRLWDARAVTKLSKTDEDEQWLGRLRTAGLSQADEIKLIMLREFIWRLAQMKGRDSTELQMEKRSELEDIIPLRNLGITPQTVMFEEEPIRYPAPQLDDDDTAPKTIQEALLDASLTIGDPLSQRRRAALDKQKSKSGSRSNLPSISVDGRPATDSNGENSRNTLRRSASHQSHASLLSPHDDVGSAHYSPYETRRALKHQSSAISLMNRKDSAKSVPETGTTETNAFGEVEASFTQHYQGTHIRSPDTESMPPTPGIKLRVNHDYHGNDPHILKMLDTMYVENYPHDLAEFGPEVTPIGRRKTGKIISSQPGKQRENGWKPKGVTIASFVEHVGAINRIVVAPDHQFFLTGGDDGTVKVWDSARFEKINIHKPRLTHRHAPGAKVRALCFIENTHSFVSCATDGSVHIVKVETYLQGESYRYTRLRTIREHRFVDGEFGVWCEHYKRDNESILVVATNKSVVWGMELRTMTLLFKLENPVHHGTPTCFCIDNKKNWLCLGTSHGVLDLWDLRFKVKLKSWGVPGKGSIYRLSIHPSRGRGRWVCASGGTGQGEVTVWDIEKATCREVYRVGGNKEGPKGYDAWQVDEDKPSDGQGQMLSRFATNIEPNAMGNADRGVRALVFGWGITDAATVEEQPPPPLQERDVRYAFMITGGSDKKLRFWDLTHVSQSRIYSGLQLGEAAPSYTASHPTPSLILNTERLHNGKSSSGGRSGAAAAGTGGGSVTAQGVNGKSSSSSNSANNAQQKMRPSRTKIISQEHFRLLRSHLDSILDVALVESPYPMTVSCDRGGMVLIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J940</accession>
    <name>A0AAE0J940_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_292510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678540.1">
        <property type="nucleotide sequence ID" value="XM_062823028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J940"/>
    <dbReference type="GeneID" id="87860182"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3339180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="147" mass="16373" checksum="690C79AD3A1E33AC" modified="2024-05-29" version="1">MASNQFDGQASTNYKEAFSLFDKRGNGRVALDSLGDLLRACGQNPTLAEIRELEKNVGGDFDFETFQRVLNRPGGFRDPGEPEEYCRGFQVFDKDMTGFIGVGQLKYILTNLGEKMTDEEVDELLKAVDTSSGQVNYTELVRTILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J942</accession>
    <name>A0AAE0J942_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="17">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">B0H65DRAFT_531462</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="17"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678704.1">
        <property type="nucleotide sequence ID" value="XM_062828942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87866096"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000036">
        <property type="entry name" value="Aspartate carbamoyltransferase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="564"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="1102"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="26">
        <location>
            <begin position="1359"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAK3339344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1832" mass="202695" checksum="FCD7348B6F832A48" modified="2024-05-29" version="1">MAATVYRPATAPIADAPCEGLVCLELEDGTAYQGYSFGAPKSIAGELVFQTGMVGYPESVTDPSYRGQILVITFPLVGNYGVPSRETMDDLLKDLPAHFESNQIHIAGLVTASYAGEDFSHFLATSSLGTWLKEQGIPAMYGVDTRALTKRIREKGSMLGRMLLQKEGLTVSAPSLGVPGDWKPHFDTIEWVNPNEKNLVAEVSIKEPKLYKPDDATALKHPSGRNLRILCLDVGMKYNQLRCFVKRGVEVLVCPWDYDFSQEEYDGLFISNGPGDPKVMDATVKHISAALHKNNTPIFGICLGHQLLARAAGAETIKLKFGNRGHNIPCTSMVTGKCHITSQNHGYAVDATTLPTGWQELFINANDGSNEGIMHVDRPHFSVQFHPESTPGPRDTEFLFDVFIQTVAKCTADNTLLQKGVEFPGGTTEENERLHPRVDVKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTVLINPNIATIQTSKGLADKVYFLPVNAEFVRKVIKYEQPDAIYCTFGGQTALSVGIQLKDEFEALGVKVLGTPIDTIITTEDRELFARSMESIGEKCAKSASASSVEEALNAVKDIGYPVIIRAAYALGGLGSGFANNEAELVDLCNKALAASPQVLVERSMKGWKEIEYEVVRDAQDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSREYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLGIPLKEIKNTVTKVTCACFEPSLDYVVVKMPRWDLKKFTRVSTQLGSSMKSVGEVMSIGRTFEEAIQKAIRAIDFHNLGFSESKTALMSVDDELQTPSDQRLFAIANAMHAGYTVDRIWELTKIDKWFLHKLKGLSNFAKDMTKFTASDIVGRPDLLLRAKQLGFCDRQLANFWASNELAVRRMRLEAGITPFVKQIDTVAAEFPAFTNYLYLTYNASEHDVSFEDRGVMVLGSGVYRIGSSVEFDWCSVRAIRTLRESGFKTIMVNYNPETVSTDYDEADKLYFENINLETVLDVYQMENASGVLGAMGGQTPNNIALPLLRAGVKVLGTSPEMIDTAENRYKFSRMLDRIGVDQPTWKELTSFEEAKAFCQKVSYPVLVRPSYVLSGAAMNTVYSEADLESYLQQAADVSPEHPVVITKYIENAKEIEMDAVAKDGKVVGHFISEHVENAGVHSGDATLILPPQDLEQATIQRIEEATRKIGAALNVTGPFNIQFIAKDNDIKVIECNVRASRSFPFVSKVMGVDLIEMATKAIMGLPFEEYPAIDRPAGGVGVKVPQFSFSRLSGADPVLGVEMASTGEVASFGVDKYEAYLKALMSTGFKVPKKNILLSIGSYKDKREMLPSVAKLSEMGYKLFATAGTADFLQEHDIPVQFLEVLANEDDQKSEYSLTQHLANNMIDLYINLPSNNRYRRPASYISKGYQTRRMAVDYQIPLITNVKNAKILVEAIARYRDMDIGERDYQTSHTPLQLSGQLNFTLQDSLSRPHSFKKAHVLSVEQYTRADLHLLFTVAEEMRLSVQRGNVMDILKGRMLATLFYEPSTRTSASFEAAMKRLGGEVISIATQYSSVQKGETLQDTLRTLACYADAIVLRHPDENCVHVAKKYSPVPVVNAGNGSREHPTQAFLDLFTVREELGTVQGLTFTFVGDLRYGRPVHSLVYLLRHYSGVKVQLVSPKGLELPADVRQQLVKAGQLLCESETLTPEILGKTDVLYCTRVQKERFTSEAEYEKVKGSYRIDNQTLKHTKSKMAIMHPLPRNEEVAEEVDFDQRAAYFRQMRYGLYCRMALLALVMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9X2</accession>
    <name>A0AAE0J9X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B0H65DRAFT_298019</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="16 18">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678721.1">
        <property type="nucleotide sequence ID" value="XM_062823114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87860268"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000004">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003240">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="295"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="24">
        <location>
            <begin position="501"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="21">
        <location>
            <begin position="741"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="914"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1105"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1213"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAK3339361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1429" mass="161920" checksum="53593322BE4F8DF4" modified="2024-05-29" version="1">MLLRWVINGELEDREKGLPRRIAFFLVDKVALVFQQHSFLTKNLDFPMEKLCGEMVEGVESKAFWKEALEQNEVVVCTAEILNTALHHSWIRMDQISLLIFDEAHHTKKDHPYARIIKNFYIDEKLERKPRILGLTASPVDAKTDPRRAAQQLEVLLHSQIATAADPAALQHTICKPKTELIVEYARGRPNSETVLNKQLRKLVGGQELFKKPLNFTTSEASKLGAWCADRYWQLFFKQEDIVKLESRTERDLMKVSALDEITERHVKHVREAHELVNAHTFSPAALDPTMLSSKVIMLVRILRDQFERGVGTQRCIVFVRQRNTAMLLADLLQQPEIKSHIPSIAAEVLVGGGTTGSSYVNAKVNFQQQNRIIRKFKLGEINCLFATSVAEEGLDIPDCNIVIRFDLYDTLIQCIQSRGRARRPDSRYIQMIEKGNYEHHSKILQAKGAEDVLRKFCEALPEDRKLTGNHMNLDYLLRKEKGKRQYTVPDTGAKLSYMQSLVCLANFTATLPHPPETSLNPEYYITTVPGGFQCEVVMPDASPIKNAVGKIHTSKGAAKCAAAFELCLALIKARHLDNHLQSVFTKQLPEMRNARLAVSSKKKREYAMRLKPELWSIRGEVTQLYATAFVLENPDALGRSSRPLLLLSRSALPEVASFPLFFGTKRFSKVRCVPIPGSVQAEDTLVEELTRFTLKAFMDVFSKEYEATAVDLPYFLSPMDGGHGFDFRLAKSPADLIDRKTLAYVSENEKVPYTFLEPDDFFQDKFIVDPYDGARKFFTRHRRHDMKPTDPVPDGIVAPSHRAWKGLGTTHDILNYSNSLWSKSRGFMVFQADQPVVEAGLISTRRDFLDDAIRDEDLEPQQCFLVLEPMRISPLPADVTAMLFCFPSIIHRVESNLVALDACKLLGLDLRPDLALEAFTKDSDNSDEHDAEKENFQTGMGDNYERLEFLGDSFLKMATTMAIYTLIPDKGEFEYHVERMLLICNKNLFNNALEVGLEEYIRSMSFNRRQWYPEGLVLKKGKSKAARKRHVLADKSIADVCEALIGAAYLTGQEKGSFDMAIKAVTAMVKDKRHRMTSYGDYYAVYQKPNWQTEPANSTQRDMAKKFSERMGYKFKHPRLLRAAFQHPTYPSLYERLPSYQRLEFLGDALFDMVAVDYLFRKFPAADPQWLTEHKMAMVSNQFLCCLSYHLGFNKCIATMSPSIPKDIAEYVTEIEEALEAAKQEAINAGKTADEYSRDYWVHITHASRLPKCLSDVVEAYIGAIFVDSEYDYSVVQQFFNKHVLPFFEDMHLYDSFANKHPVTFVANMMAHKFRCNEWRSLAKELDTDLSEGRGGRGGAVAGEVSEINPPKVVSALLVHGKTVAHAVAASGRYAKSAMAKKAIKLLEGMSVEEFRERLGCDCKGVPMEVDGGVPADVADGEVHGTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JA43</accession>
    <name>A0AAE0JA43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ECM13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_577686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679080.1">
        <property type="nucleotide sequence ID" value="XM_062830700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JA43"/>
    <dbReference type="GeneID" id="87867854"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3340138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34990" checksum="8AFBDD0DBAD4C333" modified="2024-05-29" version="1">MSSTTTLTATTTPPPSRPQLLGTLSTSASTYPTTTTTTTIRTSFIKPNKMSITQTYYLAHKARAKLSSEAARPDHNLRLLVGHANLLDSLMVELADAEREQESWFNQSVRGASSRSEERHIQWADAVVHEPEHDWQAEDAEYSDSDSDSDSDLSEDDHEEDNEDEDVEMADAVPLRRIPSHSSGSLHRYSMQAPLHQFYNYNDDEDMEEDVEDDEEDYTHLALQRSPSHSASPPELDLDSDSSEDEHMPPSPPTTILSTFTSSTSPKKQAGEQTEDDEEDQQEQDKDSFFTHNQGYYLPSRGPTLVSTIGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBD8</accession>
    <name>A0AAE0JBD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_578310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679498.1">
        <property type="nucleotide sequence ID" value="XM_062830724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBD8"/>
    <dbReference type="GeneID" id="87867878"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3340556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="672" mass="75446" checksum="3AA80301B17EF052" modified="2024-05-29" version="1">MSDEPAISKPAEAERGNSGDIKTQKTPPNAVPPVTKPHRHVVSAQVYDVLTLLLVFRFINAIVLRTFFQPDEYFQALEPAWNLAFGDQSGAWLTWEWQHQLRSSLHPAIFGLAYKAAHWFLSPFFPPAFETFVLEALPKIIQSVFAALGDFYTWRLATSIFGDESNIPWTALWMTVLNPWQWYCSTRTFSNSLETTLTIAALYYWPWDLLQDAKSNKQEPLQVKGNLGSLRASLILAAVAVLLRPTNLLIWLGVLTLAVTRLTLDGESPIKRSTLLILAKEIIVCGSAVLAVSLISDRLYFGFWTFPPYKWLYFNISQSLAVFYGHMPWHYYLSQGIPLLTTTFLPFALVGLYKSTSSSKTLAVLQSNILKTLSFAVLSMVGTLSIVSHKEVRFIYPLLPILHILAAPYVFKFFTAPAASAATTTTPAEGNAAAATSTTTGPVTLRHKIFLANLLSLNLLLATYLSIFHQPAPLSVMTFLRTEFERIHPDSLSLDSSSVDQAVVPKQELFALFLTPCHSTPWRSHLAYPALRARALTCEPPLHTQPGSVERREYLDEADRFYQASSPKEDGLYGVEFLREEMWGGDGLTSGSGGHGEEIPRFIVGFEGIEEVLKKFFEEDKKGREMGVGLKKVWEGWNGAFNEDWRRRGRLVVWDTGVYDEVVAEQKRSVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBF7</accession>
    <name>A0AAE0JBF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_510699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679528.1">
        <property type="nucleotide sequence ID" value="XM_062828426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBF7"/>
    <dbReference type="GeneID" id="87865580"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35630" checksum="FE032FE1273E518F" modified="2024-05-29" version="1">MTITSFNRVVASIPNGCLRGNITSFFHQYHSDFSHSFTVLVQQRTSQRTFATTSHQCHNEPKYPTSPSGPLVPGCETRERKNAQMGDNTLPSKPPANDPNPNPNPVPVVVEESPFPLTAADKWVLSQTDEEFKCHSWDELRTLIQNNDLSVLKRKPSDLRRYMKWTAETKASYGSMTNYLLAHRLPKTWGEPPFTPVSDVPFAEPSDYCVLLNDWPYGFEPGITHIVVWTCTAIATDDDKGDMTPESRNIVGDFVKRYFVDRLGPGGEEKVLYFKNWVALQSVRALEHIHVLVKDVDPALIEEWTREQEWHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCL5</accession>
    <name>A0AAE0JCL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_578897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679792.1">
        <property type="nucleotide sequence ID" value="XM_062830741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCL5"/>
    <dbReference type="GeneID" id="87867895"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="200" mass="23145" checksum="46E385908C067ABF" modified="2024-05-29" version="1">MTPSGSYILLETQGRQRLFSMTSRTASGSQNQTLDKNGLRKRPFPVNHYQEVKDLIRDVKLPCFKFGQYGTVKFLKLERSWGDREPGTVSGPRSNVAIDEKPISSMGIDTIRHHINGNTELLYALDHEYLVWFFEHWLNRGVLELLLAFEERNCPPFEASWDNDKGLRRHRSLLCLSPTPLRLDDIGLRWSTDRKPNAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCN5</accession>
    <name>A0AAE0JCN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tim17/Tim22/Tim23/Pmp24 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_468720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680394.1">
        <property type="nucleotide sequence ID" value="XM_062826978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCN5"/>
    <dbReference type="GeneID" id="87864132"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3342601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="155" mass="16184" checksum="1F7FAE924B0B8858" modified="2024-05-29" version="1">MDHTRDPCPWVILNDFGGAFAMGAIGGTIWHGIKGFRNSPYGERRIGAITAIKMRAPALGGNFGVWGGLFSTFDCGIKGLRNHKEDPWNSIIAGFFTGGALAIRGGYKAARNGAIGCAVLLAVIEGVGIGFQKMLAGATKLEAPAPPPSNEQVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JD56_9PEZI</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_428639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680446.1">
        <property type="nucleotide sequence ID" value="XM_062824774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD56"/>
    <dbReference type="GeneID" id="87861928"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042251715" evidence="2">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="189" mass="20077" checksum="9EC54EF4AF0FFAD1" modified="2024-05-29" version="1">MKAGIFFSFFALAASAFATPIIAERQIESQADQIDQLTALVRQHTANMNATAALYPDNPTLAQQTDAANKLKPDFDAVTDALKTATATLSKREFWTEPVARTDGGSCDKDCLTLKIKILVYEITCTLKFLIIKLGLGCLIPLLTPLLIALSGLLKCLDKVVAGLLFLVGGLLHSLLGGLAGGLLGLIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDB6</accession>
    <name>A0AAE0JDB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_468112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680182.1">
        <property type="nucleotide sequence ID" value="XM_062826944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDB6"/>
    <dbReference type="GeneID" id="87864098"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042239786" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="10049" checksum="609B453FAC6099F9" modified="2024-05-29" version="1">MRCFFSLSSLVFKSVLFRFSPASEAEGFKSFRKTFSSASDHVLVWKRNERRAKNQGRIFVLDMAVFEHEDTHHHGYQTKYRKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDS8</accession>
    <name>A0AAE0JDS8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7820 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_234753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680741.1">
        <property type="nucleotide sequence ID" value="XM_062822242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDS8"/>
    <dbReference type="GeneID" id="87859396"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="514"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="939" mass="101080" checksum="F51087D4AE75BBA0" modified="2024-05-29" version="1">MDPRDRKLDSPERRRSRRTSMRHSLTLRAERMDELPDPEDSALASVADDDMRHSPLYDPSPAVVALGQELRDEGLGQGGQVRARVTNDSSSPITPPTSTPILPVQPFSQAELRSAQGSPYGTNADMAATTPLSELTTFSPELPQAPLRPPSPTKRASSAADPLALRHDGATSPNLSSQHMDIDAAHSASIPGPLQPSGPSHVYEQYTRNLAFGPPLGLSSDPLARGYPYHGPSDPSPYHIYPQDVHNAPQYGRVVTQQGEVPVVDYYGPYGHHEPLPPYTERDNTGLGGSSSSSIDPTPAPVADSTPSIGQPTASTAVVSSSAPASAPESSPALGPAPAAEEPEGRTTPTAQPTQAPLPSTQTPPTTQVLATAQIEQAEQTGSAAQEAQTEALTGAGGLGLATRNPEFDSLDDLRAPRPRASTRSFNTTHSNDQINKEKAAISEKETPFKRWMRKQWCFGVVPNWALVLSLCLLVIVGIVTGTVAGVLLSKHGKPPPKDGHPKPKPGSEFPSNVIPIPTPTDLASLPTGTWSIPMMLNQASSNCFKDPAQSKSWNCHFVPSGMYLSVESSAPNRYTFTINCNHSLTMSNNVYSYGEQPVLLVNPGALVLVNDTSEANRGPAWFQAVPYNKTVILPQDSLNITTTEGTAKMRRGWDRKDYRKGYGAQPGDKPWICNWPQTTFELYIYAQQNSSWSVNTQSLPPPPATSSVPAPTDSTTMTVVVTETEIDHVVSPTASTFASSTSSPDRYNHYTTKPFGQRPPDGVVYYLPYRHRQLEADHHGQESSLSETPSSTSGPASSFPPGPMGTGPHGDGFAPPPPGYPRVVKLEERRYLDAPVPECTQFEIPFNGQAAQPVRDEKGNMVVVTIYPPEATATGSPRPSRRLGKRFTDWDLDLNEEDDSPIWSPEVLRRSEGDGGISNASGGVVPFGSQCNCEWFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDZ4</accession>
    <name>A0AAE0JDZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_548384</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681205.1">
        <property type="nucleotide sequence ID" value="XM_062829577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDZ4"/>
    <dbReference type="GeneID" id="87866731"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000959">
        <property type="entry name" value="Mitochondrial escape protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="203"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3344592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="867" mass="97280" checksum="18AF547BA4A9B3AA" modified="2024-05-29" version="1">MISAHILSRQATRPGHRVPSFTTHSTALLLQRSLGQGLPVSYRRTTRAWESTSSSTASTGSHKESGHIDTAPHESLLFFNNLFPLKLSSILIWRPWTSEDLLQRFEQSSYSFIDPIRLVKRAINAHDQVPIKVTEIIPRLKDGGAFVKFTYPSDMSAAEVESKLSKLLHDNPIKPWFNPFGRVKTGLVEGVPWLEDLYRLPRSRIRVEFVAAKDDESPAELSQETLYSIFRKYGKISEITSQPTDSKVLPRFAYVDFVLVRDAIMARNCMHGFVLREQGSKNATKLRLSYEQRVKAHHIWAWFTSHPRIVIPLVAALIAAFTVAVFDPIREFFVKAHVQKYFEFTNSRLYKWFKSQTSDILAFRRRKTEDAGLNALFTHRKDLIDSIQTGLLESVDTFTVVHGPRGSGKKELILDQVLKERSDVLLIDCKPVVEARGEAGTIRRLAFEVGYRPVFSWSNNISSLVDLAVQSTTGVKANFSENLESQVVKILQTTASALKQVGLSERKKEDKDADLSEDAYLEAHPERRPVIVIDHFLHKSEEKGVIYDRIADWAAALVQSNIAHVIFLTDDASYSKPLQRSLPDRVFRSVTLGDLSPNVAKKFVISQLQTDTKFAHDGQQQDSEPDGQDNDNKNEKKDSNTPAPIDPALLHELDTCITALGGRLTDLQVLARRLKIGQSPQKAVQEIIDSTASEILRMFLLSKSPSSDKKYTTEQAWYLISQLAASPSSSIPYNSVLLSNTFASSPETALEALANAELITVKSQNGMPSEIKAGKPVYQAAFQKLASDEKVKARMDLLVLTELAKIETQKIEKVEQELVMLQGLMARRPGDVSERVEYLLEKMKGGQAKLKGLEEEMGVVKGRLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE47</accession>
    <name>A0AAE0JE47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_508521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681280.1">
        <property type="nucleotide sequence ID" value="XM_062828230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE47"/>
    <dbReference type="GeneID" id="87865384"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="71569" checksum="4275AA68FC28B514" modified="2024-05-29" version="1">MDDKTKTNQDKAAINSIPHIFNVYDITYVIFEHMGHTADLKNVSLTCRVLNAAVRHRLFRFMTLPGAAIGGFPMRSLLRDRSVSRRLIASAIPFTAPQPLRDGWGLDDLEFLGQCHEIYEATGIILSHATQLQHLEFTGFHLWLNVLKLLHMREIKEGFCSIESIEITRPGKLIDALIFTENGELHSCVFVRKMALILISNPKTHLVADMSMMVGVKGRVMPEFNLRCLTNLALHGLQFQPTAQNNTALSPYLLPLVVLLKNAEQLRCLELSTYSNHRHLTRDRALAGGSSFHPAHGQMMRTLCLNHKQAGASPLQHLRYLRLGPGCELDFRRYNLPETYPHCFLPYLFTLSGLVELHLESSCLGQGTFSGYANAAKLLINPSCLPKLRKLSLPCNIWHSWGSNNTDRKLAYTVEQALTMRFVGLFDMPPLSGLVLPTPYIDLQDIYRIEELQRIKDLKSVKTLLPSLCETADGKYTPHYGQPHQIKHPWENEPDLPRNLQYINFLLKELTNLREVWLTGDCGANWNVSWEDAYCEYRKMIRHIYLHHGDQIEYVATTFFQRFPKLEYIRILHRAWRRARKDRNNNGEASGPIRELTPWEVKNDIPEAFDYRTPSLFRGRQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE65</accession>
    <name>A0AAE0JE65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_496927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681013.1">
        <property type="nucleotide sequence ID" value="XM_062827800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE65"/>
    <dbReference type="GeneID" id="87864954"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042011821" description="Glucanase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3343220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="450" mass="48857" checksum="AD9C91A1B7B9FF70" modified="2024-05-29" version="1">MKAYLEYLVAALPLLGLATAQQVGKQTTETHPKLAWKKCTGKANCSSVSAEVVIDSNWRWLHDSNGKNCYDGNKWTSACSSATDCASKCQLDGANYGTTYGASTSGDALTLKFVTKHEYGTNIGSRFYLMNGASKYQMFTLMNNEFAFDVDLSTVECGLNAALYFVAMEEDGGMASYSSNKAGAKYGTGYCDAQCARDLKFVGGKANVDGWAPSTNDANAGVGPYGGCCAEIDVWESNAHSFAFTPHACKTNKYHVCEKDNCGGTYSEDRFAGLCDANGCDYNPYRMGNTDFYGKGKTVDTSKKFTVVSRFEENKLTQFFVQNGKKIEIPGPKWDGIPSDNANITPEFCTAQFKVFGDRDRFAEVGGFAQLNSALRMPMVLVMSIWDDHYANMLWLDSTYPPEKEGQPGAARGDCAQSSGVPAEVESNYGSSKVIYSNIRFGPVGSTVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEQ4</accession>
    <name>A0AAE0JEQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_181239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681236.1">
        <property type="nucleotide sequence ID" value="XM_062821507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEQ4"/>
    <dbReference type="GeneID" id="87858661"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3344623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="373" mass="41181" checksum="6F579C6185C7BD61" modified="2024-05-29" version="1">MVTHALSMCDLHLDMDHHDAGFLDYPSSSFSGVSSSYSFASNGPFTPSSGSSTPARHNSMDFGPSFAPPVDNIFTPPPSSVSAYFPLNMKAGDGSDFLATGMPLTPSRNQLNNGHQMYYNDVGTHLTSPQQMDYYTFHNGLAPSPLAPSPAVQAIQHSNTYDAWSVWEQAESPIFGKFLSPSSNSCRSASRVEQEGEMSPMSAGGHSYPSPAGKRQLYVEEARQKTTALQMVQRDVPLAPRPTMHMNGEGKPEQDSQNTYGPGSILIDPIQRVSAGTNICDYPGCGKTYRRSEHLKRHKTNAHSEVPIWYPCSFCDKKFNRPDNRRQHLGLHAKPRPTKMKGVKYAPKAKAALEEELKNITRRNKKPKAEHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEV4</accession>
    <name>A0AAE0JEV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_464783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681488.1">
        <property type="nucleotide sequence ID" value="XM_062826775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEV4"/>
    <dbReference type="GeneID" id="87863929"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3344875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="280" mass="31446" checksum="F63417FC43013ACA" modified="2024-05-29" version="1">MSKTGSISLQVLRDSPVEAGETNAQIVDALEAALNVNDDALIPQAAKRLAEQLDSTILTRDDPADKESEVENARYNVYTTLLAAVQQVPADHEAHRRFALVLRDLAGLDGHPAWQRLEGFAICNRDAWQDPTLSFESVTDPKVHERWCNLNAFVATLLSTGAINWRELPIWELRDGLEESLEELSQEGKDTRVVVATLWIKHAGKFIWEHSLAGKPEDLDETDSRMLRAGELYQGQPGYSRDRWDFWKKRLGELRSQVSNLRSSAIEEAIGAMTELEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEY1</accession>
    <name>A0AAE0JEY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_184137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="365"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3344743.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="496" mass="54293" checksum="7E83FCC0C4B903FF" modified="2024-05-29" version="1">MSKSKKTAAKRKQNVESTEASAKRVKTAAGALPSPPAESGPEVDRFEPKSITTVVSEEELEVTVDTLRTLAENPAIIKSKACKELRSVVYDFRQACTTGINSSSDANLTAKVSGFLADGKFVDALVTLAEMRIRGDIPRLGALCRWVRDLDITSGLSQTETTNRQSRPELLKIMDAILRATGQPIDASGLGDSSSTTWTGPIALQNMWDIREPSTTPFPMRQSVLDGTLFSVCPPNVKDLFNAIETTPGPQRKPPNLHPAVLHLSNEGAVPLSPTSPTITKHQHPIVPSLSILKDVLSPAECKSIIAATESVGYLPDAPIKEDGSESSILAHNVYWIVDQTFHDALWERVRPFMPTHDAGRKARGINRRFRVYRYVPGAEYRCHFDGAWPPSGIHPTTGKYMYDASPADKKQSSLFTFLMYLNDEFEGGETTFFTPSVRDGVMNAHPVRPVMGSVAVFPHGENHGALLHEGTGVRKGAKYIIRTDVEFDVDAGRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_198130</name>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821742.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87858896"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="18532" checksum="8A94D1D6DFE0D57B" modified="2024-05-29" version="1">MYSSYGSYSSSASSSRSSSYGSSYSSISRPMDISPINISSSGPDASCAFPSWPRRTSLCESESDYERPTSFLSDEDLMGDVFDDDVRSVSSSGSSPMHSPPKAPFMTEAEILEMQREQAAYQREMVSLLVREKERRKAQAKRQRSAGKASSKKSTKSKLSAMTPIAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFK9</accession>
    <name>A0AAE0JFK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_466579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682030.1">
        <property type="nucleotide sequence ID" value="XM_062826861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFK9"/>
    <dbReference type="GeneID" id="87864015"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3345417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="399" mass="44765" checksum="10A5364898CFD97B" modified="2024-05-29" version="1">MASARVVETLARTGGFGTRVARRRLLETFQHILDVTEGVESMKPPGGRGWRSTVRVRFLHGMVRRRILGLSKKKKEDGRGGGYYDAEKLGVPINDLDSIGTIASFSSALIWMGLPRQGIFLTSQEIKDYLALWRYVAYLIGVPDTITITIPSSSSDGHSTQRKITPFGSAQEAKMVIESIMLSELSDPSETSAVLANNIIAALANQPPLRSSASFLRAQAYWLNGSSLCQTLKIPKPPVFYKMLVGSQCSFFMVFCYLRQMHYLLLRWVPPWDSNEKNDEEGGVTAGQTQERYKRVRRLMRNVVVEMAGGKEAEFGFEWVPERGKYTGSERGEEDEEEGDGKGKGRLRRKGWWEWIVSRNGGSEFRSLKTFLVASTVVGCLVWIGVRGLLFGTMPLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFS2</accession>
    <name>A0AAE0JFS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_208052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682122.1">
        <property type="nucleotide sequence ID" value="XM_062821888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFS2"/>
    <dbReference type="GeneID" id="87859042"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="112"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="367" mass="41232" checksum="732E5F7BF27BBA63" modified="2024-05-29" version="1">MQTHPHIMQCTEDVPCPWGMSKSFASTYAGFFGWEDQSFEVSNIPTPYKRKLEFDLVAKISRGLDDCAKHHAKSCRISNKAPPPSRLLDVGSTSGEVRLVETKLLQTAVQKYNCLSHCWGTQQPLETTRQNYSRHLTSIAWDSIPKTFQDAIQLTRGLGVQFLWIDSLCIIQHDDKDWERESADMCNVYGNSYLTIAATSSPDCHGGLKYWENRELFKMTGFTADKSPVKISLVAQPTKGFIKGDTPLLHRAWALQERIMSPRVVHFLPAGVVLECNGGWLAEFPERQLKSGHVEKTKHHEAISSNSIETKANMWRNLIETYSQSALSFASDKLPAISGLAQQMAKHRAGARYLAGLWSDTLTTDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFV7</accession>
    <name>A0AAE0JFV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_548968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681856.1">
        <property type="nucleotide sequence ID" value="XM_062829618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFV7"/>
    <dbReference type="GeneID" id="87866772"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="114" mass="12562" checksum="DBEF9CDFCF0DA8D6" modified="2024-05-29" version="1">MSNPPNPESLFLDTHWQAQLTYGAEPPLVSESPLVVPEAYHLKFSECVTTGATTNKLAGYPTSVYTPYALSSAVATAATTGGLGVWYYVRLKKRQELDVEGNHLHWDCGWQYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG41</accession>
    <name>A0AAE0JG41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_427180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682319.1">
        <property type="nucleotide sequence ID" value="XM_062824670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG41"/>
    <dbReference type="GeneID" id="87861824"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3345706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="81" mass="9701" checksum="553BB20F446F8152" modified="2024-05-29" version="1" fragment="single">VYINDIVIVSDLVDDYFKYFNTIFVLFVSKNIILLFKKLYFDYLSVELFGFYVNGFGVLTIKERIEAFKNYIFPDNLKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGB4</accession>
    <name>A0AAE0JGB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_146364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682404.1">
        <property type="nucleotide sequence ID" value="XM_062821013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGB4"/>
    <dbReference type="GeneID" id="87858167"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041912421" evidence="3">
        <location>
            <begin position="33"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3347322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="826" mass="91773" checksum="BC5DFDC29C38A5D6" modified="2024-05-29" version="1">MAYPPRKVLNSRLTFLALGLLLLGIFPQPIEAVHRYNESQCCLDAVASEVFTLNVTRNPKTGEILSSEAPICGQMYNDTLKPAPEIRVSYAYCKSNCGGFGLSKGDEPGQWAAPIVQFLLPSVIFSMNVPRRHILLSTTRFNDWVWRILSRPGDRKPRKVVALLMGIVLLALDTLIGALDALLWIVVVMGMAGPMMVGGLHEAVLDYKIVRALKEGAHKEEGTEKQPPTLKSLRDTVEVLVTAISGNLVMGDNGGNPEVEIKKALLAEFPEPDCEVLNDQRPLSSQDTIGPVPQLPPIARLCQAEPSEQDGSQEPEGPPIIVAPPEIKLQPVDIEASKKLRERLTRLISSQLDFAATIGAPVVFYLGAFIYTILDIRNKPSDQDAAISLAFGVEWMIIVHVAIIGGCLLASNNPSPVVLLVGKEAPEDRGSTKDAQWIYFTRKNAFDGLFQPVNMWKRGINKSNWLRQSEVYRKNKKFRDRVKIQLLEYFGWIILQTFILISLPPAAGAFVAWRTPPIGWSCRSLSFVTYSASQLLLTLVYSAYLNMWERDQARHKKHQGEDAESGQRRSRNTYQVVHERAGRDASANGYDRPLEDLQQVHTASSPPRLPSLDMDMDDEEDTDRGRYELKEIRTTTKLLPSTPSPGPSSRHIEYPSPDPGREPNSSQNANLNPTSSPPATPRASMTLLQSNFQGQTCAVHTKPKKSLLTFSIHILFTTLFLLSLFLSIGTTLMQIMGVYRNCFCYITVRYWFDTSNPDAKVNVASDTWFQRNSSYNWMVMGGVATAFMAACAYAGWWFQGMIRRGLAGVVAGEVWPGYGNEKGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHD2</accession>
    <name>A0AAE0JHD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_158113</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682959.1">
        <property type="nucleotide sequence ID" value="XM_062821194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHD2"/>
    <dbReference type="GeneID" id="87858348"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="69"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3347877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="526" mass="56283" checksum="67ACA48936CB52ED" modified="2024-05-29" version="1">MRPPTSTLRRNVLLDRVVCQLVPQSRLPGTLRTLITSSRASASIPSQRLKAGYFVSNAFLPRVKANGIHDSASSQRSSTVASSTSTTADTTDGSSSTTQPTTSTDLPPVDNNLLPHRRRQAQRKAAAAAAAAAEASQSSDTPTPLINPDAPTADLAPDASSQLAAAAASAPADSFKRRLSSLLSLSKPRLTVLVVLSAMVPYALYPVPSFLTSSALDTSLAPSLSPLTLLFLTTGTTLCSASANALNMLYEPDTDSKMTRTRTRPLVRRLLTTKAAVFFAVGCGLAGTLALYFGVNPTVSFLGAANIALYAGAYTPLKRISAVNTWVGAIVGGIPPLMGWAAAAGESATGDGTWRELLFASDGSSLGGWLFAGLLFAWQFPHFMPLSWGIRHEYKAAGLRMLAWTNPARNGRVALRYSLAFIPLCVGLSATGVTEWSFAVTSLPVNAWLVWEAIKFWRLEGHKGSARGLFWASVWHLPVIMVLALAQKKGMWGRVWRSVFGEPEEEEGEWVYEDEEEDVAKAVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHH3</accession>
    <name>A0AAE0JHH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_461350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682843.1">
        <property type="nucleotide sequence ID" value="XM_062826593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHH3"/>
    <dbReference type="GeneID" id="87863747"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042240343" evidence="1">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="25180" checksum="9DBC0C2393496DE1" modified="2024-05-29" version="1">MRIPFYRFCFLVFCLVLDRNNNSVVNNLSNMIFQYFCVSLPYSTPLSAMKLGHQVGIRPSITLEVYRPCLTNHHDITSTHRKTYIPHVPFPADPDQSRQCLTITDIHNLIATLLQRLPNHTSRRTEPRSTLPINDRRQKLTRPSYLTHWMEMEDPILRYRNLKHQMKIKIYNVAPPSHLVRLSGHAWMARLLVQYVPPYLYNFIYCIYSAGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JHZ5</accession>
    <name>A0AAE0JHZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyoxalase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_423107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683319.1">
        <property type="nucleotide sequence ID" value="XM_062824435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JHZ5"/>
    <dbReference type="GeneID" id="87861589"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39175">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39175:SF1">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15168" checksum="329CE7D7E72A9D41" modified="2024-05-29" version="1" fragment="single">QVNILVPPSTLHHATLFYGTTLSLTSRPVPSLQAGTLAWFDISSSGQQLHVAIGRPDVDFTPEARQAKRHPCFRGENAEKLRELQERIWEHYKRGGEGAPMQCDEPGSVESGAQGVEYPTRFFARDFAGNRLEFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIT2</accession>
    <name>A0AAE0JIT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_419129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683727.1">
        <property type="nucleotide sequence ID" value="XM_062824186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIT2"/>
    <dbReference type="GeneID" id="87861340"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37048">
        <property type="entry name" value="QUESTIONABLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37048:SF2">
        <property type="entry name" value="QUESTIONABLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="376" mass="42141" checksum="1082EA8CC4D2E14F" modified="2024-05-29" version="1">MPTTPSSRRHSQRNRRGSTPPTPGHNGSKLAGRIMWLPHANELSSSTGFPEESHNHPVLVLSKKLSADGKVDILMMTSFGGMDLETRHRYSRIQLRETFLPIDPSPPHPDNNIQLKLDHGVTLRKNSYVKTEEQRQILFSLLRNYERHTNKIYALTDASYQIVVEHSGYREPVHSVTVPTRIQPVAQPQPERVSSYGYGTIPTSQPYPASRPAQNTQSNYNGYNNYQYNSGVHSQRKRNSAGPSGHSSGGSPDDLSPNAQVVLGLILIATFACGAAGVYWLLQNFFSWASEGIRHGKRHCVEGFKRVDWHRVAKAFGSFSWHVVVALAKVVKCVVVGVARAVEWGAKGAWRFAMDWVMETEKGRLGHRLEHFFPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ38</accession>
    <name>A0AAE0JJ38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_421206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683862.1">
        <property type="nucleotide sequence ID" value="XM_062824325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ38"/>
    <dbReference type="GeneID" id="87861479"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="6">
        <location>
            <begin position="129"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3350567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="467" mass="52227" checksum="19A46956C99603D9" modified="2024-05-29" version="1">MLMGEQTGTTGHSWSSISAIIAHWRSYRHIHRIALVIFVLLTIFVLERYRTALASTFQTSSETRDPIAVPGGNSAAQQENHYEPYPEATNQGGGGKHEEETQLTPEQLLELSQTNAGNSTLGFHAIKYINMKARYDREDAMALQAYMSGLDIEDYPAVEADMIDPVGMPPTHRPGKLKTGEKGCWRAHANIWSEMTRHRLPPILILESDAAWDLNIRAIMSRLNSHFISFLNQINSTAVHDPSFGSPNNHKVHGPPPPYSPDKPIVANPDDPWLSAHWDLFSVGQCFEYTQDHEIKLVYDDESVPEGNDYWGQKMGKERVIRKSGGITCTTAYAISHTGAAKLLLRSALDLDNPVDLLMRRLVMSRDLVSYSLFPPVVAQWEYIGGIGMGERGAQSDINGGKHKDTPENAHMPGWKDVKDTGSIWTTKGHHRDVAFDKMALKEAWTEIIGEEPKKFEESLYNPETGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJ69</accession>
    <name>A0AAE0JJ69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_424034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683636.1">
        <property type="nucleotide sequence ID" value="XM_062824490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJ69"/>
    <dbReference type="GeneID" id="87861644"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3348554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="490" mass="55190" checksum="95573531F77FE7D7" modified="2024-05-29" version="1">MAVHHQFDTVKRKWYHIKWFADSDTPRERRLIMKLDLLIVPYAFLAYWIKYIDQANLNNAYVAGLKEDLSFHGNELVQLQTLYTVGAVVGQIPFMFLFTYLPIHWTIPFLDIAWGFFTLAQYRANSFAQMAAYRFLIGWFEAAFYPAMHYIFGSWYRGDEISRRGGVFYSGLTLGTLTAGLIQSGASARLEGVNGLAGWRWMYIICAVITIPIGILGYFILPGTPEHPNKWFLKNEDVQIAKERLARVGHSVVHPKFKLSTLKSLANNWKFWALMLLDIFFWNGSINYSAGGYLLWLKSLGRYSQSKVNELGTISPAIGIFYVLFICFISDLVVGPAWAITIAHIWNIIGLIILVIWNVPESALWFAFMTTYSSVAMSAVLYGWVNAVMGKSSAERSFAIVLLNTVAQSTTAWTQLLTFPTKEAPQFKKGYSFVLANAVCLIITAQFLNVALKRSNKPVDAEQNAETGSTAASNSEKGQEEVNVTPEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJJ0</accession>
    <name>A0AAE0JJJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_548177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683482.1">
        <property type="nucleotide sequence ID" value="XM_062829562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJJ0"/>
    <dbReference type="GeneID" id="87866716"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3348400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="231" mass="25531" checksum="80A358A47A289C54" modified="2024-05-29" version="1">MKSGRGSDLQEKAYWDLGQNAIRDNWLPSSHIGSGLRHKDLGGCEDGPEDVKEAERVSIIGGLVDVVHPDSLGPVGLPMSMGLSLWATTQCAGVRVDVPVPGSPLREPQVLPVFAKREIPKKPLITPTIWLWDWGIAYLLILLAVQLQLGTPRCMCLSPPYLPSTTIEPSTFPRMASPEYHPPSCAYLLAARYTIQRNGAHIKMMEQRNTYRPWQTLCASLRLATVQPKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJJ3</accession>
    <name>A0AAE0JJJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional Coactivator p15-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_97894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684044.1">
        <property type="nucleotide sequence ID" value="XM_062831643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJJ3"/>
    <dbReference type="GeneID" id="87868797"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.31.10:FF:000006">
        <property type="entry name" value="Putative RNA polymerase II transcriptional coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3350749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="171" mass="19267" checksum="344582AAA089D4A1" modified="2024-05-29" version="1">MPPKRRQVEDTSDAEPQYTKKSKGNTGKAQPQELTKGSDQDGNTFWELGNNRRISSSVFKNTTLVNIREYYDANGKLMPGKKGISLSLAQYQNLLKIIPQLNTDLRKQGHSIEDPEFAEVAEQTDAPVESPKVKALESKKENNKKEKKPRKSNIDVTSDEEEAAEDEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJM8</accession>
    <name>A0AAE0JJM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BCS1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_421259</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684240.1">
        <property type="nucleotide sequence ID" value="XM_062824331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJM8"/>
    <dbReference type="GeneID" id="87861485"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042127908" evidence="13">
        <location>
            <begin position="18"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="86"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="392"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="461"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="538"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="745"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="824"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="552"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3350945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="946" mass="104005" checksum="BEEF2618A1F13401" modified="2024-05-29" version="1">MNCFMLIIWVLSTLVDASTDSGETINITTTTINDTTQAPTVSLPDNLLASFSPMLDMYVPPAVRDFLLSCHRAITSWLGFDPTILLSLGPIVWAAKRLWSEVKVLVIEDIICNWFTARVEVGDDDPIFIHIMRWVAVQPNSAKTRFLQADTIAGSADDHDEDDEAGAVAAAGAAAVIKTATTTTGTTTTVVTSTSTSTTSTSTTAATTTDPSSNTSITTKNKKKKQQAPTILPNGEACLNFSTHKHQKPPRFLPAVNVPYTFTFAGTYFWLNRTRSNIAHQSEWRGLSMRREENLVITAVGFSASPIKNFIQFTKEWNHNRQAATTVVRRPARPEMRSWGGRHVWAEVADRPIRPMDTVVLDEKQKLMVLQDMNEYLHRETAQWYGERGIPLRRGYLFHGPPGTGKTSLSFALAGVFGLDIFVISLLDQNLTEDDLAMLFTNLPRRCVVLLEDIDTAGLVNRREEDESESSESSSSSGGEGSGTSDSEDDYLESAKKRALEVMFLGEKLSRKKRKGRGKEATAEQEALEKEMAEKVAGFKEMLKEGSDEEKADEKASDEKDSTPEKKEQKPAAPEGEEKPTSSADDAGENGEKTTKHESSSTTDKKKKKPMTAKEKKDKKKQKKKKRAKMFAATTLHNVEFVRRQYGRRRPSPYDRERGISLSGLLNAIDGVASHEGRVLIMTTNKPEKLDEALLRPGRVDIQIAFLNATQEQVRELFERMYEADVVDPATVTFTKVGNKLTASTTSAATTSPSVVHSPLTGITSPGGTGTGTGTGTAAAEKDEEKQQQPAIDPKIVDLKLLDDNNLHKSSVSSCSSDATVIGEEDNAASSASPPPNTHTTTTDTNTTTAAAAEDKQKQQQPEKDKKEGPVPLHVTPLTREELQKIAKEFSLKIPPTQILSPAEIQGFLLRRKKDPRRALAEVDKWVEELVKAKESKSKILDAKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJP6</accession>
    <name>A0AAE0JJP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_546048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684270.1">
        <property type="nucleotide sequence ID" value="XM_062829424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJP6"/>
    <dbReference type="GeneID" id="87866578"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03775">
        <property type="entry name" value="MATH_Ubp21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="103"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="259"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3350975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1192" mass="137640" checksum="80021916DB9438FB" modified="2024-05-29" version="1">MGNLTNHALLTPSRSPSPRTDYLANLPIRNKDDQNPQAPSPNAMLVDTPEEHIVEPNGVDNDDVAIITPEADEKEAPVLATDYKTMKEHVLPALIDEPPILEDQVHTWEIKGWRNLNKKEHGPTFHAGGFPWRILLFPYGNNVDQCSIYLEHGFEADEMPEKWSCCVQFALVLWNPNDPSIFHHHSAHHRFTKEESDWGFTRFLELRRLFSQPYDGSTRPLGENESVNISAYVRIVEDETGVLWHNFNNYDSKQETGYVGLKNQGATCYLNSLLQSLYFTNAFRKIIYQIPTEQDESMMNSAYTLQRLFYQLQTSNTAVATSELTKSFGWETRHIFEQQDVQELSRKLMERMEEKMKGTPHEKALAQMFSGKIKTFISCINVPYESSRVEDFWDVQLNVSGNKNLLESFQDYIQVEKLDGENQYYAGDEYKLQDANKGVIFQSFPDVLHLQLKRFEYDIQRDTMMKINARYEFPEEFDAAPFLEKDADRSEPWEYELHGVLVHSGDLNTGHYYAFLKPTKDGNWYKYDDDKVTKARKLEVLEDNFGGPFRLPNGQVRTLPQKKTPIMRPNSAYMLVYIRKSRVDQILTPVTEEDTPPHLRNRFAEELAAREARRKEREEQHLYIGVKVVTDTTFQQHGGTDLTYFDLTPDQDPGAPIYYRVLRQDTMEQLVAKIAADLGQDPRRVRLWIMVNRQNKTVRPDVPIMDLALTVEETYSKATAQRDESLRVWAEVAEEVNADGEPIWPSHQAQANGAIVKDNILLFLKWFDVESQTLRGAGHVYVRLDKKVEDLAPVILKKMGWGEKLPSGEKIQLWEEIKPTMVEPLRGKETLKAEELQDGDIICFQRTHVHKSRLGLGESKPSEDAKSSDKLTDAREYYDFLYHRKVVRFCPHPQKADVQQYPQFELVLSSKMSYDKLSEKVGEHIGVEPTHIRFYTINGANGNPRTAVKRLSNQTVERILTPPGYGQMNLNQLSDALYYEVLDISLAELDTKKSIKVTWLSEGITKEDQYDLLVSKSGVVEDLIEALVKKAKIPSEEEAGQIRVFEVSNNKWYRDLERNYPVISINEYTTVVAERKPEEEIGVTDPNQYITVFHFQNEPSRAHGMSFRFLIKEGEPFSETKKRLEKRLGIKGKSFEKIKFAVVRRAQFSRPIYLQDDDILYDKAEREDYLGLDHVDRSRSTRNGGGDLFLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJS7</accession>
    <name>A0AAE0JJS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_555962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684330.1">
        <property type="nucleotide sequence ID" value="XM_062830042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJS7"/>
    <dbReference type="GeneID" id="87867196"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="96" mass="11193" checksum="9E1DB231F6689EF1" modified="2024-05-29" version="1" fragment="single">MHNPSAEETLNVGLDIDTDKALFPDIESNPGHGEQELERAPRRQRRRHSIIFGWLPRLNIDFFSRNPRHRVSYLSPSIRPLLLRSAFFLLPSFLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JK24</accession>
    <name>A0AAE0JK24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_545793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683986.1">
        <property type="nucleotide sequence ID" value="XM_062829405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JK24"/>
    <dbReference type="GeneID" id="87866559"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3350691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="421" mass="47297" checksum="F9229A1D210B4F46" modified="2024-05-29" version="1">MSDSDTQPLLRILTAITFIPSLPLCITHGVLSHNPIPAVGLAPMTLSAGYSVLLLTYRRRSKRKQNNRRSIGHAEEDNDLESVRNGDEAGISSREPLIEGGAEEPEYPASERSQAEQTPAWEEEAEEKKTPLYAHTIFIFFVDSILAAGIMVVLVFTWINTQKGRTGITNPVLGGKLAMLAAYATIPLLASLSLIHTYLALRGFAIGLALYPLIQYAAWHTLPPDCPNCNSRLRPASRPKIPWYDFVSRPRNLSLRPTFKAPKWWSNRQQRRTVVDVVGAGDVDDDATARLFVRNDDLESVSHLGEGVVAVERYRDEPDADEDAEVENVETRSYRDEPEGEDNDRQEPEQEQLPEGQGGEEQEQQKGQTEDLLEVQPEAHQEEEGQQQQSEQQQREQDNDARSERLERIESRDRALTPALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKK0</accession>
    <name>A0AAE0JKK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_107226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684353.1">
        <property type="nucleotide sequence ID" value="XM_062820509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKK0"/>
    <dbReference type="GeneID" id="87857663"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="528" mass="59503" checksum="A2ED32987C92B75E" modified="2024-05-29" version="1">MSYEHRCLMRRRLELYHDILTEQLRPRIEAAAAATTEHDDSDADQYIDDDTDNTDDTDDSDEDLCEWEHAENKPSEESYARVTQWRCGLEGNRVWEKDAPDYFENTEKVSDQVELEQQDDNEAFPTTGVHHVEHSGSGSAADTSVQTSGGPPTPLSDAVALDPMAKVEEQGRAHNGDNTLNDPKTTKREEYSTALLNDMASGSESPKDDSLDRLTTPPSSPCPESSVTANPLFMKERNHISLHPQSNLINHSQSLPTNSRLSQSNRRSKSLPPLNLLPSHCPPTPPPETSSPSTSTYSQLRFTVTQAELDFFYKHIEQVEYMIRGIDYQFQMQEYRNEVRRQNRRRRRRAEVEERLMFIAWGNEMSSEDWSNVAGMDGTEHQSWENTAVTGEWDSGGLEGDESADAKEEGDDDPSSHRPGEKGEGCGTDGHREDGESVGADGAGDEDAVVAEEDGSSENGWDSGAWSSTWSEPEEKTQLHQPTQRSPLRKGYTPDDMVWEEAVAEAEYLGFYGHQFKKDERGRRHWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKN1</accession>
    <name>A0AAE0JKN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_457704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684674.1">
        <property type="nucleotide sequence ID" value="XM_062826368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKN1"/>
    <dbReference type="GeneID" id="87863522"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="215" mass="23818" checksum="8CB60BE90DA76FDD" modified="2024-05-29" version="1">MDTCRDDPLVQAVTAYVKDYMSNYDASHDWSHIERVVGLSHYIYSKSANKDSLDLRTIHLSALLHDVGDKKYLKSDQDPTTLIATLLTSLSCPAPLASKIQTICLNVSYSTETKNPANPGFINSLIEQHPELAVVQDADRLDAVGAVGLGRMFTFGGAKTGRDMAGSMEHVDEKLVRLVDLAKTDVGRELMMERTERLRAFQGWWGEEVGFVKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKP2</accession>
    <name>A0AAE0JKP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_456665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684301.1">
        <property type="nucleotide sequence ID" value="XM_062826308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKP2"/>
    <dbReference type="SMR" id="A0AAE0JKP2"/>
    <dbReference type="GeneID" id="87863462"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="174" mass="19769" checksum="830D206C39E827F3" modified="2024-05-29" version="1">MGNTTSSVLDNIVQGSNFDREEVDRLRKRFMKLDKDNSGTIEREEFLSLPQISTNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEQKLRFAFKVYDIDRDGYISNGELFIVLKMMVGSNLKDQQLQQIVDKTIMEADLDKDGKISFEEFTKMVENTDVSMSMTLDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKV0</accession>
    <name>A0AAE0JKV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_546146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684376.1">
        <property type="nucleotide sequence ID" value="XM_062829430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKV0"/>
    <dbReference type="GeneID" id="87866584"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="240"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="672" mass="75101" checksum="C5E5881DBA02F3EF" modified="2024-05-29" version="1">MSTSWPSLRDATSSLLKGAGTTAQVATYVGCSHHENTRRVTIPGSSNPDVQITITVLTLENISTRDLLDAREPDPTTGLFRRQCRYCRLLCDIFDAFFIDEYMSWITETRNKMPISVGLMICEGKPLVVNCWGFTYDRHTLFSRVDLELYPDPTAALVPSPTSGNIPTMGPTGHRAETVASGACFEFIRECVAQCCIEHQNSQCQPRDIGFVPTRLLYIGKDNNDLRLRMGLPPTEDIRWAALSHCWGGGAPFKLLQGNLMTLLEKVEISDLPPTFCDGIRVARELGLQHIWIDSLCIIQDNKTDWEVESSRMGMVYSQAFVVICGASSSNPQTPFLGPREPEWLPKRFNLQIEDGQSLPIIARQRHLLAAPLEQGLLEPPYTGAWATLKRVGPLEDQLPPYPLLLPGTLGEEPPDADKWRMTVKAYTQRQLTFASDKLPAIAGAASKTPQAQRTKYLAGLWQESLLLDLLWQVMPGATHKALTYPDESGRVVPSWSWASMDRGVTWNPLQRPELLSELVTTHVDVDGQNPYGAVAGGKLIIRGHVKQCFVETSRHKNEQWVYYRNPQKNTTSKKLHFRADGQLMPQVAPSASSNIACIRRARGEEWEDEVHGQGVFLCIGRTPWMNYNYVGLVLSWSSSPNSPGCMERIGNITNVPSDWYDSGEWVTVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLD4</accession>
    <name>A0AAE0JLD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SPX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_419076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685077.1">
        <property type="nucleotide sequence ID" value="XM_062824180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLD4"/>
    <dbReference type="GeneID" id="87861334"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="541"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="778"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="813"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="903"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="935" mass="106524" checksum="3D995D90C08E7751" modified="2024-05-29" version="1" fragment="single">RFAKELEQEAVPEWRVKYLNYKLGKKLIKNVTRAIQRANTTPTLARRPDSQHPLHATPAALFHHLSHKRTSTHNRWSDDTPGPHEDSPGTDYFPGGGPELGLAPAKNNRSSRSSIGLRGERSSLTRSPDSEIRYGSILPPSRSSDRTEFELPAPAMKIASRTGGRRDSIPTTPTSPSSVDVPPSATIAKRPTHRLSRVLSNTSRLSRTMSNKDDIGLQNLDSVRTAEAEFFSFLDNELDKIETFYKQKEDQATKRLTALREQLHEMRNRRTTEISDAKQRKEMERRSGSRSHSDDDGGNNGKDNGIDWIGPIRTKFMKPGPNSKALQKMTETPVMAPQKPEEGRDYVRRPPNKDDVPYRVAKRKLKLALQEFYRGLELLKSYALLNRTAFRKLNKKYDKAVNARPTYRYMNEKVNKTWFVNSDVLDGHIRTVEDLYARYFEKGNHKVAAGKLRNILRRPVDASDSAFRCGLLIGFGAVFAVQGLIYGSELLFQDDHTLKENTSYLLQLYGGYFLMIMLFTLFTLACRIWTKNKVNYPFIFEFDTRHNLEWKQLAEFPSFFFALLGVFIWLNFSRFGENWEEMYLYYPVVLIGVSLLILFFPAPIFYHRARRWFLYSHVCILSSSETSSSAISAFWDLFMDFSLLQKNARHPFLRDITALKSKWIYYAIMIVDPILRFNWIFYAIFTHDTQHSTIVSFFVAFAEVIRRGIWLILRASRDTPLPYQLDQFIERPSQETSAEELEVETGTTTGAVQQERRGTISSMAASIRERIRGSIVAGATAPWTASTPTGAAHPEEEGPTSPHPDSGATPGDGATGTGTGFNLSGGGTFRRRHNESMGKKSILQAMAEAHKQDFEKRRPPEALREEGLGRRGSSSLVDEDDEEEDDDDPDLRSEMEDDEDDDSDRRSVQEDRMEAREAETLVRRGRGEPDDSVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLT4</accession>
    <name>A0AAE0JLT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H65DRAFT_131273</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684998.1">
        <property type="nucleotide sequence ID" value="XM_062820808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLT4"/>
    <dbReference type="GeneID" id="87857962"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="437"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="141"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="415"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="530"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3351703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="740" mass="80851" checksum="325C91F33931FDF1" modified="2024-05-29" version="1">MADVISPDAPGAGGAGGDAPNATNKFQSAISQWRSLDFTSLVSNLDNTASEIVTFQRDSTVQRKDLAQKTKDFRKLDDATKLGEIKGLLKAYQGFIDLLTNHSKSVNTAFLHAYTSLSEAPDPYPLLEASVDSMLVSEDTLPKLTEENNHLQKNVAKLTSQLEETESRLQKESDARKQLEENLDSKVKEVESSWTAVLDEKQDNWTAKEKALEDKIENQDRLLSELKASYEVNQRLGKSDDAEEQTGHVTSAELEMVQSDLERTSTRLAEVEARNEQLRLELAQSKSQVSTQPAASLEDDPGYLRVRSENSSLIRKLDAARVEKEGLKRDLDTKLRGLEREVGLLKEERDALKAKVQKWSDYDDVKQELEVLKSIEFATGDDDDAVRAVSGNNAEGDNEAGGKGDTLEQLLLARNKKLNDELTILRVSHQDLQNRLQDLQEELSRTNAELEKSQNLNEKLEDELSTIQAEAPNSFPSGASVARYAPSIAPTRKLGGGRISPTSSIVSGFNPRGADRDSPDFAGGGAGGILPMITAQRDRFKKRNAQLEQELSETHRTVSQLRQEIAALQRDNLNLYEKTRYVSSYNRAGGGMASATSTASFSSNPNPSAVSFGAASGSDGNNGGGGVALDRYRKAYESNISPFAAFRGRESARAYKRMSLPERAVYSITRMVLATRTSRNLFAAYCVALHVLVFLSLYWMGSADADQHVVTAAVGAVGSAAGGAGGSGGGEWSEEGFDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLW8</accession>
    <name>A0AAE0JLW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_538022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685344.1">
        <property type="nucleotide sequence ID" value="XM_062829081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLW8"/>
    <dbReference type="GeneID" id="87866235"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041926197" description="Prion-inhibition and propagation HeLo domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3352049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65663" checksum="DAC9ADE047649BA3" modified="2024-05-29" version="1">MSGFEVAGLVLGALPLIISALEGYAKGAGAIQQWRFYTRELRILKRGLETEHVKLQNVCEKLLMGIAQPPIIEKMIENTFGPLWKEAENPEIYHKIRQRLWRAARIFEENVKDMNRALQELQEKLNVGPDGQPRLDTQGVSFRKELKRLSFALNKSVYLELLTRIRDGVSSLEALTSQNSDLEPERNKRSNGRLYRIMHSLSGGIYQALCTAMTACQCPTSHLLGLKLSSPPHTSVIPDDEDEDVVRNLSVKLAVSDQNIAHGKLDRLWCSLVVKPSSRPRQSQIYQQPTAPVESERPTKRARKTVMFSFSENPAARRPGLLSRYSSQSSGEVEVTSRSSTQTLTLDVTKTKPEASNEDIIMDLCETVRQLPSLQASGCCGHITGPAAVDASATERYGLYALGHLLPSDSFGQCSFISLHEVLTEQLTAPAPFYDEDRLRLAYILASSVLQLAGTPWLTTKVTTKDIFLIRCNGTTHLQEAIVVRQLPAPSDLMQLDAQPPQDYSWASSSSRSCSAHHLIASASPIPNSMVLQRWDRSSPTTRQQQRCLAGSRPKAAQTTSALLNDASSASFPRRSQTSTVMNSGDLCMVMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JM29</accession>
    <name>A0AAE0JM29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_459500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685213.1">
        <property type="nucleotide sequence ID" value="XM_062826463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JM29"/>
    <dbReference type="GeneID" id="87863617"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="357" mass="39174" checksum="D16FFAECC4D6D8B3" modified="2024-05-29" version="1">MAGLFGSAAASASNTLGDLKQDVELGQPPEDSITDLAFNPNPADQKDFLAVASWDKKTRIYEILSNGQGQGQAMIEHDGPVFSTDFFKDGTKVISAGADKAAKVLDLATGQSMQVAAHDMPIKCVRYFEANGTPMAVTGGWDKQIKYWDFRSANPAATLQAQERVYTMDVRDDLLVVGTADRYINVINLKDPGKFYKTMQSPLKWQTRVVSCFNDSQGFAIGSIEGRCAIQYVEDKDSASNFSFKCHRDPAQGNTTAVHAVNDISFHPQHGTFSTAGSDGTFNFWDKDAKHRLKGYPNVGGSITSTTFNKTGSIFAYAISYDWSKGYQGNSPTYPNKVMLHPVQQDECKPRPSVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMB6</accession>
    <name>A0AAE0JMB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid desaturase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_420493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685333.1">
        <property type="nucleotide sequence ID" value="XM_062824280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMB6"/>
    <dbReference type="GeneID" id="87861434"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459:SF1">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459">
        <property type="entry name" value="ORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="162"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3352038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="464" mass="53614" checksum="463659CD23366A93" modified="2024-05-29" version="1">MEHIVFAHDLTKADRVVLETLATDYSDHLKAKEKDVPDSAYASASDGETTRTTGTNTDGTKGGVNKDKNKDSSATRTSEAISHLSSLNDPKSPSFEPSITNFFDLADLQSFKWLPPSLLSAYRQWASSLIRTPTDILMITHLLIYFSTTVPSAFYLLFVRFSWPHAILHAVLNGWYVGTYTLMMHQHIHMRGILTKDKWWTRVFDAVFPYVLDPLMGHTWNSYYYHHVKHHHVEGNGPDDLSSTIRYQRDELSEFAKYVGRFYFLVWLDLPLYFVRKGRYEQAAKAAFWEYGSYAMLATMWKFAPGGGKAVFWTLVLPLMVLRVGLMVGNWGQHAFVDDEEPESDYRSSVTLVDVASNRHCYNDGYHTSHHLNPLRHWREHPVAFLKGKETYAANNALVFHNIDYIMITVRLMMKDYMTLAKCMVPIGEFQMNMTLEERAAYLRRHTRRFSEEEIKEKFGKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMH3</accession>
    <name>A0AAE0JMH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_507286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685261.1">
        <property type="nucleotide sequence ID" value="XM_062828130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMH3"/>
    <dbReference type="GeneID" id="87865284"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="539"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="901"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="997" mass="107236" checksum="E6BA31591D596547" modified="2024-05-29" version="1">MMNSTGHLPAGQPMQGNADMGIPRMNGGPGGQGHLGQGHGPRRGRPHHNHYNPGAHHHHGQYHQPHVAHNPMYAANYMPQPYGVPPGYYAPPAYQNAAMTNPYGMPQYAPPQATYARSPPAMQHYMPMVAQNPYVRPAPPQSPIVSTPYQAPPMPAPALVPVPAPHTPSSTHSHVVPTPMTPPAQQMPPIVPSQAQIQSQPQVQVQPEPEPNIQQKVVEEPVVEEAKQPAQAEAAYSHFASPQKSDKPPFSLPWFSHPDTPFPTRTKLRRRRQAPSAASESVSLPTAPGQQPASETTQAAPAESTPTDNVQEDASVPTLTGTPKLEILPPRSETPSTQELPSVDTPSTSPTSSIPSQQLQVSESIMASPSQPAKQATRVPVPAVPAVPVVPVLPKPAPKDKPTPSAEQPSAEAKPAESAPTTEQTPETAAKDVTASTPESSAPATQAAPAPAPAPAPAKPKSWANLFTRPAAPVNTAAADAAAASAAQTTVNSHTSADASGAAAGVITGFAQSKANSMAEAVQSYRVGTAEKIAFLEPRGLVNTGNMCYMNSILQVLVNCIPFYDFLDQVSKKAAHSFNSETPLLDAMIMFMREFKVIDSAVSIDQLKRRLKSEELEQYGEAFTPEFVYDAIRKLPRFASMRRGHQQDAEEFLGFLLEGLHDECTHVMRTLPVSTTSTAPNSSLPSPTTSNAGDDWLEVGPRQKAAITRTSGYSSSISPITRIFGGHLRSELRIPGLKSSVTLEPYQPLQLDIGAPEVRNIVDALRGLTRPETIHGDFNSPHGKDAKATKQVFIESLPPVLILHLKRFQFDAEGHGTIKIWKKVGYPLELEIPREVVSRQKRNTIHAENADLLKYRLITVVYHHGKNASGGHYTVDVRRQDGPEWVRIDDTVIRRVRAEDVAEAGAEEKPSKGAVGDRRENGSSAASNRFGAMNDDDTGDDEGWKQATANGKKWSSVVNGAGLAAPSGSGSLKAAAKQHNDSFKDNKVAYLLFYQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMS3</accession>
    <name>A0AAE0JMS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nitrate transport protein crnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_421169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3352116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685411.1">
        <property type="nucleotide sequence ID" value="XM_062824323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMS3"/>
    <dbReference type="GeneID" id="87861477"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3352116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="557" mass="59405" checksum="F7A497595873DCDD" modified="2024-05-29" version="1">MVLGFQFSFQPPPLNPLTKKAQRIPVFNPIDRHGRVFFFSWMGFMVAFWAWYTFPPLLTHTIKHSLHLTPTQISNSNILSLVATLLVRLISGWACDRYGPRLVFASILLLGSIPIGLAPLITNVTGLYIIRFFIGILGGSFVPCQVWCTAWFDKNVVGTANAVAGGWGNAGGGVTYFVMPAVFDSLVGRWGMSEGKAWRVTFVVPLVCLLVCGLGLMLLCEDTPGGRWRERDRGLNLGAAEGRAEGDEETVIEGVDPKSASGAETPTATATATATMDEEEKGSAKTMSDTESTTRTRPDVERGEVVVPASTQNLEGTTTPALTILLSPQTIFHILTYFCSFGSELAINSVLSSYFLSISPSSLTQTSASNYAAIFGFLNFFTRPLGGLVSDLLYKSFGGASSTSSTTSPSPSPPKAKPLWARKLLISLSTLLSGTFLLLLGLLAPTSLGTVIGLVILAAIFIEAGNGANFGLIPFVWPERNGVVSGVTGAGGNLGGVLFALVFRFVGGHGGKGGYEKAIWILGVVNLVVGVGGLGVRPVPGMGSIRREGGRRRRWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMV8</accession>
    <name>A0AAE0JMV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_448822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685914.1">
        <property type="nucleotide sequence ID" value="XM_062825918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMV8"/>
    <dbReference type="GeneID" id="87863072"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00925">
        <property type="entry name" value="Cyt_c_Oxidase_VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3354536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="136" mass="16089" checksum="7BDF8E8A8F2CCAEE" modified="2024-05-29" version="1">MFAQRQMFFARLAANLRAPAVRQTVQRRFASTPATDSGKNAFVRERENVKKHAAETMELWRKISLYGIPPALALAGYNAYTLYNEHWEHWSHLPPLEERTEYPYQNIRTRNYPWGDGDKTLFWNESVNYHNRDKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN18</accession>
    <name>A0AAE0JN18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_2309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685546.1">
        <property type="nucleotide sequence ID" value="XM_062822175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN18"/>
    <dbReference type="GeneID" id="87859329"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="408" mass="45314" checksum="21A3CCA6DD0B4CE4" modified="2024-05-29" version="1">MSSTTKDPSTTAGAGADSDSEDDYMKMTFTDEPSSTTTTSSKSGKKPIETSLQRRLRLQREGEIRGRVKSKAELAAEEEARREAALSTSLFSKVIGPPSSTTTPSSTSPSSAAPPLPTATTTKSKGLAMMAKMGFVPGSALGAGAKSGTSSDARTEPIKISIKDGREGIGLESERKRKLREAAEAAGEMAKKARVDEEGYRERVRREREEARLERQVVAAQKVAEGMDEDYENEVGGCGEKGGGEGEVQKSEERDDDDGGDSQERRRKTRTNSSRPLRSIPVVYRGLVRSREEAERERRMRYDLEQSSLLSSTRLPTYVDDELDMDDKHALGKDTTTVHKPWNTYVMAEDLDEEDPELDEFNALSPDERLRRLVQYMRDKHHYCFWCKAKYDDAEMDGCPGLTEEEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN44</accession>
    <name>A0AAE0JN44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_437737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685753.1">
        <property type="nucleotide sequence ID" value="XM_062825328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN44"/>
    <dbReference type="GeneID" id="87862482"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="178" mass="20183" checksum="ACDDCF5F8E0BDA7F" modified="2024-05-29" version="1">MVSVTKALALTSSSTTLVNANTHTLEIEEGKPPEHYQQVVRKSKKLPSDYDTGVKRARYRTNYERNLLGLLRYNYSEWEDQVISESTAQAWEFHVSAASSGWRTHLKQYVVVSKSSPVYKYAEDGNIVELKKLFSQGLATPFSLSEQGSTLLHIVSSTQTLRLHHPNNHYAGRRGQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNT1</accession>
    <name>A0AAE0JNT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_543641</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685687.1">
        <property type="nucleotide sequence ID" value="XM_062829241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNT1"/>
    <dbReference type="GeneID" id="87866395"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="203"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3354309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="476" mass="52567" checksum="566EFE4E3F81C2F9" modified="2024-05-29" version="1">MASRRLALNLAQGVKARAGGVINPFRRGLATPHTGSGIKTQTTTLKNGLTVASQYSPYAQTSTVGMWIDAGSRAETDETNGTAHFLEHLAFKGTTKRTQQQLELEIENMGAHLNAYTSRENTVYFAKALNEDVPKCVDILQDILQNSKLEESAIERERDVILRESEEVEKQLEEVVFDHLHATAYQHQPLGRTILGPRENIRDITRTELVNYIKNNYTADRMVLVGAGGVPHEQLVEMADKYFSKLPATAPVTSASILSKKKPDFIGSDIRIRDDTIPTANIAIAVEGVSWSDDDYFTALVTQAIVGNYDKALGNAPHQGSKLSGFVHKHDIANSFMSFSTSYSDTGLWGIYLVSDKLDRVDDLVHFALREWTRLCSNVTEAEVERAKAQLKASILLSLDGTTAVAEDIGRQIVTTGRRMSPGEIERIIDAVSAKDVMDFANKKIWDQDIAISAVGSIEGLFDYARIRADMSRNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP23</accession>
    <name>A0AAE0JP23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_450614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686444.1">
        <property type="nucleotide sequence ID" value="XM_062826018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP23"/>
    <dbReference type="GeneID" id="87863172"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="139" mass="15741" checksum="BB5936DA3A7BAF2A" modified="2024-05-29" version="1">MYIQQENVWTSHLLYFRLITHGTNRHKKSETTEIITTKETDKENLTGQPSQIVPIPFSFLSAPTEQKQFQNSTSKDGLAAVGWKGIGPVAFPLTAYCVRRVTSLPSFGGFWRSDRYHGIPWLFFTASSLSIVSCFCFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP33</accession>
    <name>A0AAE0JP33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_23287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686131.1">
        <property type="nucleotide sequence ID" value="XM_062822212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP33"/>
    <dbReference type="GeneID" id="87859366"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="300" mass="32957" checksum="568B200C5327FD24" modified="2024-05-29" version="1">MAKYKPQDATTNPSLILAATKKPEYGALLDAAIAEAKKGPGSPEEKVDAALDYLLVQFGKKILEIVPGKVSTEVDAALSFDTKASVDKALHIIKLYEAEGISKDRVLIKIASTWEGIKAAEILQRDHGINCNLTLMFSLTQAITAAEAGAFLISPFVGRILDWFKAHTGKDYSKEEDPGVASVKSIYNYYKKFDYKTIVMGASFRNIGEITELAGCDYLTISPNLLEELLNSDAPVPQKLNAADAHSLSLEKKTYINNEPTFRFDFNEDQMAVEKLREGISKFAADAVTLKDIIKQKLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPJ1</accession>
    <name>A0AAE0JPJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_416066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3355332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062824023.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87861177"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042011822" description="Fucose-specific lectin" evidence="3">
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            <end position="565"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="552"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3355332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="60773" checksum="BE5F33F8D5B21C29" modified="2024-05-29" version="1">MALFGAMSIPKPLLTLLLVAASVAPSEATMASWWNTVASQVVVLNETTGQYRYTRCNSMGMDTIYYSTTGGNYLNFTKSPPKAGSPLTGTGWYDQTNAWASLFYFDESNSIRNAIFKCDPSTGLYMDSESQFWPVVAEGAPTPHNNSGMSGFLRDQNRGYWLYYHDEDMHLNGLSYDPDTTTWTWEGTINHDVQGSNAIAATAGKGQSNFTVVTPRDDKNIEVTRWGLDQNWYISTTPHPLKGNFSTSSAPSSSFEIDYSAPSNYSLPSWTGQPKSIGISLDTVYNRYVYYIGSDKSLYRLTSQNYSWSLWENQSTTYWPQADEANAELAVVSAIITDTKTAKVRIYYVVGGKLAEVALDGNDNDWKQWRAVPEWDPNSANSSTTTSPPNPSATSGSGSGSATGVATEPASGMSSGAKIGVGVGVGLGMMAMGAIIAAVLLFRRNKNKNSADLNSPEDGTTVVGSEAPTATTSPLPPYGTLATGYGAGAAGAGAGWDQKMPPGGGGGYTNVQQLDTTERPMELDAPRAVYELPDQTYSHELMADNTATRVEAPGDHGHQGQETRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JPV5_9PEZI</name>
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    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686242.1">
        <property type="nucleotide sequence ID" value="XM_062827952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPV5"/>
    <dbReference type="GeneID" id="87865106"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ44</accession>
    <name>A0AAE0JQ44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_46872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686783.1">
        <property type="nucleotide sequence ID" value="XM_062826977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ44"/>
    <dbReference type="SMR" id="A0AAE0JQ44"/>
    <dbReference type="GeneID" id="87864131"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3355405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="106" mass="11912" checksum="D3197632B61B0AA1" modified="2024-05-29" version="1">MVNVPKTRKTYCAGRSCGKHTLHKVTQYKAGKASAFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECSVCKQKKQLPLKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ87</accession>
    <name>A0AAE0JQ87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_417072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686846.1">
        <property type="nucleotide sequence ID" value="XM_062824064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ87"/>
    <dbReference type="GeneID" id="87861218"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000316">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="34"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="659" mass="71648" checksum="25B2BD764D393828" modified="2024-05-29" version="1">MNPRKTKNNNIVPLLNKLSISDGWSTVVNVTYSEYVGTELGNGVSQWLGLRYAAPPVGALRFAPPQDPLFYSEPQAANKHGNWCVRQPGNSLTSEDCLFLDVYAPTNAITDSKLPVFVFIQGGGFNDNANPNLNGTGLIKASSNSIVVVTLNYRVGPYGFLTSKRQVVANNGLRDQRKALEWVQKYISQFGGNPNHVVLGGASAGAASVAYHMMADKDGNRKLFHAAAAESVSFGTVLTVDQAQYQYDNLMIRLGCASSDSAASLACLRSKTQKEIADKDDDIPYPGSSNGPIYMWSPVIDGDFVTDSPYSAFRNGNFAKNIPVIFGDDTNGGSGFAPGRISSLGDSNQFIKDQFPAITLSQLDTLNKLYPNPHASTCPSMGCWRGQAGNVYGEMRYMCPGLYLNDAFDNYNDDYQKGTSSWAYRWNVEDRDQMASGLGVPHIVELNALFGPTNMWYSGQVPKSYLPGGTNAAAVQVMQGYWVSFIKTFDPNKLRCCGGVEWKAWKSGDKASAQHQRLLFGTGGKTAMEMIPFDDGLGLRCKYLQVIGRASADRPFPCFTQHGYGDRPSAVQPEPWPRPPRLPRTFRTAGIVSIPKNREAQAVRAFPTCTHGPTTSRLVQNGHPACALPPPSLFKATSAGVSPSRHFPGCRPATSTRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQA5</accession>
    <name>A0AAE0JQA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_46128</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686761.1">
        <property type="nucleotide sequence ID" value="XM_062826588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQA5"/>
    <dbReference type="SMR" id="A0AAE0JQA5"/>
    <dbReference type="GeneID" id="87863742"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="307"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3355383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="361" mass="41271" checksum="BC0BB81D5014CC0F" modified="2024-05-29" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFAIYLNYTRSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNAQAIQQAAGNSSQPQPADSKEAAQAAARKDPQQALRSGSRKPMTGETPETSRAVGGSDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQB3</accession>
    <name>A0AAE0JQB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_505055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686467.1">
        <property type="nucleotide sequence ID" value="XM_062827961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQB3"/>
    <dbReference type="GeneID" id="87865115"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042234340" description="NTF2-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="157" mass="17016" checksum="B07B3B180EA2D16F" modified="2024-05-29" version="1">MRFSVLANAAFASSALAIPSSLNSAIAPRQEGACLTRAEAKEIVDIYVQLIANYTDEVCAKYCASDFVDRSDSINTFIFTPLGQPTFATKEIFMAAQNANPPFPVVVDSIDAVDCEAGITIIGTTKREGYAQIKSLDVEFNSLIWLLNMGGNYTWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQL0</accession>
    <name>A0AAE0JQL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_517182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687224.1">
        <property type="nucleotide sequence ID" value="XM_062828675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQL0"/>
    <dbReference type="GeneID" id="87865829"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="633"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="731" mass="82295" checksum="EF2B94209E20F291" modified="2024-05-29" version="1">MAKDKKGKSESKKAKLAEKKQKQEKKAEKKAKVKSAKVEGSDAEDVDLDAVLEEYKKQQEQFLKVTENVVEDPPRARAASTLMASPSNSNQLLLFGGEYFNGALATFFNDLMVYYIDRDEWRCVTSPNAPLPRSGHAWTRGGNDSTGVYLFGGEFSSPKQGTFYHYNDFWRLDPSTREWARIETKGKTPPARSGHRMTYYKNYIILFGGFQDTANQTKYLQDLWLYDTQNFVWHSITPPPAQLKPDARSSFTFLPHDQGAVLYGGYSRVKATVAAGKQTKQGGGAGGSKNILKPMIHQDCFFLRITQPPADAPPNTAPTVRWEKRKKPANTPSPTRAGATMAYHKGRGIMFGGVHDVEESEEGMESEFFNQLFAWNIERNRFFPMGLKKARAPGKKAGGGNGEGGRERVGRRDRAKQNEEELLRQLAALQAGAKGLDGDADEMEIDAILKKQRGEEEEEEKDEKRKVRDMPVSMEMPHPRFNAQLAVQDDVLYIYGGTFEKGDREFTLDDLYAIDLGKMDGCKEIFKREGDDWIESEDEDDDEEDDEEEDSDEEADDEEDAMEVDDKKAKFTPSERKKKKAKDGDEAPVAETAPATAAPEEEEESEETRVDDGLPHPRVRFTFCLLCFESWLTQTPQPFESRRDFFQRTSAEWQEILMTNLRWKGIQPESLAVKEIKTKAFELSEEKWWDCREEITALEDEQEAAGIGEVVSLADKAGAGGGGGGGAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQT7</accession>
    <name>A0AAE0JQT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_505251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686707.1">
        <property type="nucleotide sequence ID" value="XM_062827977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQT7"/>
    <dbReference type="GeneID" id="87865131"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="457"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="576" mass="68501" checksum="D157E6B11898B429" modified="2024-05-29" version="1">MASRSRVEFDDYYRESPRRAPSRAPSRAASRGPPVRYADEDIDIHIHERDRTPAFLRDDRRSEAGQLVLRQREVETVERPRRRSPSPVHMHERIVHRARSVSPEPRRRTEESDIHIHTVDRVRESSRPPADRIRASTRIVERQRSPSPPRMERLEIRETQRERQRPRSPSPDRNIREHIRIVEREKEREPSPPPQPQQPQVIKGPVIEREVITHYRDIDHGMISVRPPSRPASPVRRKQPQLSETEIDIYTSRKDTEIDIHRHASKSRGRSQERRSPRHAYDDDLMIHADAGRLHVDVERRRSVSRSGGRRAHSEAPPHIDFDDEARYITSKIDSRGQMGEAYNGITKDWTIIDVPPGTERVRLDGAGGASAEVTWQKYSGVRRSQFIPERDERSVVSASSASDRDYDRERDRDARDSRLSIQIYNERGGDDRERVTERITDKRISIHGSQNPRRSEMWTEITKDLVTREAIEELGYDYEETEYFFYIMQYLRYEDVLRCVQLSDKIRQARKDRIREIQWEREYSRDDYDFRDHHHNNQSHSRHRSRDDRWDDDRERIVEHEVIYDRHSTVGGRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQX6</accession>
    <name>A0AAE0JQX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_585654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687459.1">
        <property type="nucleotide sequence ID" value="XM_062830931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQX6"/>
    <dbReference type="GeneID" id="87868085"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47711" checksum="6AE77D3D14796BA3" modified="2024-05-29" version="1">MEFPADHNSDRAIGSMSRLPAAAEALPAQDGKAMATDIGFIDDQESNVAGGHTGNGAATASNVVADSAVCTSMSSATIQPSTPDTKNYEAPNNLTNPAPTEAEESTSNQIIASNNTLGPEPPCTTVASTAPVPTYYPPRRPNIFKARAKHLQWDRNPIATDVVNKAEGVVEDVDDGEDFTMEDLEEFNSIRRQQIQKKTERFVRMVQQTVWHLRVEDLGSVQEIEELDLIKTISTMFKVLQHHRALARASEQQEDGIETPLRSPYQQIEAHPFRRPAFGDSPPKAKRLADLDTHTTVRAPSATNNPGSQMSANKEKTRDFGEDIGSHVFNKRRPAALSEGFLSRLATPLKIQPNVAQPTNGFSHHYLRRGTDSTATPKHTISTTRTQALPTPSAPLIELSKKQDDTAKPEKYRQRLHESQFSLSYLKRRDGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MK03</accession>
    <name>A0AAE0MK03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_75266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676684.1">
        <property type="nucleotide sequence ID" value="XM_062831364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MK03"/>
    <dbReference type="GeneID" id="87868518"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="63989" checksum="F1C6AE9C25A74C11" modified="2024-05-29" version="1">MIPQIMRPSVKRLATRGLSTRPALAVTSCQRHRFLSLSSRLQNTNTTTPAGEDERQPSPTTTTPVFETDAPRRRGRRPKSTTSDLNNYTPPPDAVPGSASSYSPASNSDISSLSTFLKSHNQLSRNIHETCSQFGAAHRWGPGENDTGMNRLALTDADKQVRNWFVKEARALGCEVEVDEMGNIWAIRDGVSDRRPTKDGKRLPPVMMGSHLDTQPRGGRYDGVLGVMAGLEALRALKEQNVKTWRPVGVVCWTNEEGARFPVSMVSSGVWAGEIPLERAHSLKEVSGEGKTMKEELERIGYLGDKKCSFEEMPMAAHFELHIEQGPILEAKGKKVGVVRGSQAYKWFTIEVVGKEAHTGTTPYAQRADALMVANSMIRYARYKGEVQGVLVSVGVYQVFPGSVNTIPGRVKFSLDIRSPSDHTLVSFERRLRRKFDVIAERPGFSGLPCSVTWQEDTNSPAQGFDERCCKAVKESALSVLGAETGDLEQALGLVKYQMVSGAGHDSVNTAKRCPTSMIFVPSKGGLSHHPEEFTSEEDCVRGAQVLLESVLRFDREVWREDLNREKAGEQLVRSRKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNQ8</accession>
    <name>A0AAE0MNQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_297624</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678708.1">
        <property type="nucleotide sequence ID" value="XM_062823108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNQ8"/>
    <dbReference type="GeneID" id="87860262"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="19">
        <location>
            <begin position="209"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3339348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="522" mass="56848" checksum="11EA243973FDA916" modified="2024-05-29" version="1">MTIDTDSAEVRNAQRREKFHEADVVIVGAGVFGCAAAYALANQGRSVILLERWMHEPDRIVGELLQPGGLQALQKLGLGHCVEGIDAITCYGYHVVFHGEEVAIPYPVVDDQGKVHSGEAAARVESTTSNGGKTNNGPQKLRRPEGRSFHHGRFISQLRKACASHPNITIFETTVTSVIRGSHSEQVLGVETLTTDRSTGEKQPDFFFGQLTLIADGYDSKFRKQLLPPGPNTTPVVRSKFYALELIDCPFPPSNYGHVVIGKTSPILLYQIGTHETRALIDIPHNLPAASPANGGVRGYIENTVVPTLPASVRPSVLAALEDGKIPRSMPNSYLPASGKANTARTPGVLLLGDAYNMRHPLTGGGMTVAFSDVVLLASLLHPDRVPNLADSAAVETAMKEFHWRRKAWTSIINTLAQALYSLFAADDWQLDALRKGCFAYFQMGGAKTDEPVALMGGLLHEPVVLARHFFTVAFVAIWLHMCERVGSVWGLWKAPLVLVDAVLILWKACVVFLPTIWKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNZ1</accession>
    <name>A0AAE0MNZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fructose-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_476891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678948.1">
        <property type="nucleotide sequence ID" value="XM_062827394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNZ1"/>
    <dbReference type="GeneID" id="87864548"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023079">
        <property type="entry name" value="SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF35">
        <property type="entry name" value="SEDOHEPTULOSE-1,7-BISPHOSPHATASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01958">
        <property type="entry name" value="S17BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="12">
        <location>
            <begin position="235"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3339588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="363" mass="38424" checksum="34D4A87E21A3C418" modified="2024-05-29" version="1">MTTSHSLKAVAPPATPLTAALTTRLASLLPSSSSNSRDSLRTSVLPSLLTAIAATSTALRAAQHVSLAGSSNSFGDDQLNVDVLAEEAIRLCLAQCPSVVTASSEEDPVEKPVQHTGLPFQVVEAEQDRTHGEVYTVAFDPLDGSSIIAPNWTVGTIFSLWDGTSALGASPREKQIGAVLGVYGPRTTAVVALRFPGEERGVCFEVGLSDSSEAGKGQEWDLIRSSVAYAPPPFKTRYFAPANLRSTNTHAAYAKLVSHYMAENYTLRYCGGLVPDVVHALVKGHGVYLSPVTETSKAKLRRLYELFPLALVVECCGGRAVDPVSGEDILGEKGVEGCDERGGVVCGTAEEVEYAREVLCGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPK6</accession>
    <name>A0AAE0MPK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_474721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678200.1">
        <property type="nucleotide sequence ID" value="XM_062827264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPK6"/>
    <dbReference type="GeneID" id="87864418"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="109" mass="12666" checksum="618768DC3369AD15" modified="2024-05-29" version="1">MILIPTEIDCITTAKLLATALPHFHSDSVKQGALALPGGEACKTCYLCLVCRPRRRIIITIRIRRSAKYWERIHKLAWGPEMEVRMGWRVRYNFGRGREEEVPREEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQE4</accession>
    <name>A0AAE0MQE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_495131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680061.1">
        <property type="nucleotide sequence ID" value="XM_062827784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQE4"/>
    <dbReference type="GeneID" id="87864938"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000270">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="133"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3342268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55872" checksum="93785D7C642B87EF" modified="2024-05-29" version="1">MPYITEGEPRPIGSYPDSGIDVLIVGTGLAGLTAAIECRRKGHKVRILEKCPDINTQGDMYFMGLSATKFFKHWPEMAEEFDGISLHNAWIETYKHEGELVIPPIRVAERLREAGLDPDTPPGLFQMRPLVYRMYIRQVERLGIPITFNKKVVDYWEDVQARKGGVVTEDGDRYEADVVIAADGVGSKAQKLVGGQVRAMKSGRAMWRAAFDIRYLDQNPEIKEFFSMHTPEGGGKPEPIVRTWLGPGTYAMSLTRPDTIIWIMNHDVTGSEKESWTHTVEADDVLKNMDNKLTKPWAAELKELIKLTPPKTIINFELFWRNPQPKWASQGGRVINIGDAAHSFLPASGNGATQAIEDAVSLAACLQIGGKENVAQSVRAHVRMRFIRNACAQKLGFSNAELLQDTDWNKTRVDSRHAQPRMPKWVWQHDPEKYAYEVYDRVVDSMKKGIPFDKDFDMPPNYPPGYKYEPWKIEDIRDALRAGRKVELGSGDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQI0</accession>
    <name>A0AAE0MQI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Yeats family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_430090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679819.1">
        <property type="nucleotide sequence ID" value="XM_062824862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQI0"/>
    <dbReference type="GeneID" id="87862016"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="234" mass="27087" checksum="C9165AFD4704C931" modified="2024-05-29" version="1" fragment="single">ICLQRKIKVVTEQHNINKPAAQEGYPMKEWTVELYILDQDGKERPARCFTKVTYNLHPSFANPIQTFNDPPFKCTNEGWGEFEMIIDMYTTEKGGKISIAHDLNFQQSEYENIHTVTFRNPSQALQQLLRETGPLPSDEERKQKKAVDGGSKKKRPYDIERMADGLTKLGEDDLLQVIQMIHDHKDDNTYIQNNLDAGEFSVDLYTLPDNLMKMLWEFLVSCPPSYQILLVICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQZ6</accession>
    <name>A0AAE0MQZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_559251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681017.1">
        <property type="nucleotide sequence ID" value="XM_062830125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQZ6"/>
    <dbReference type="GeneID" id="87867279"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="288" mass="34622" checksum="D8C932E5BC1FF12D" modified="2024-05-29" version="1">MDELKKLEENLPSPPNRGAKICVRIFSDCRGLLSSVRTSKFAASYQSAGKAIVEKSEEFRQNFRNLFGRPDVIVDLAVHWVLGHDKSLKLHVQADKLAGEAREEKENEKEEEKEKRENREREKEKNDENNDEKEEENVDEKVDENVDEKVEEKEEQNYEQNEEQENEQEKEEKEDKEAEHENEKEKEEEQQVETRVDEDEKSNGEQLTWPIPSFHSQTLREEAWRQYEQEPSDRDAYFPDPRRLRQEPYHHQWLDQVQQNPDPFFWDRQRGLGHHFTGRWRWEPASYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR41</accession>
    <name>A0AAE0MR41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_589678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680464.1">
        <property type="nucleotide sequence ID" value="XM_062831042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR41"/>
    <dbReference type="GeneID" id="87868196"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3342671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="447" mass="49815" checksum="71D25BB8DDE2F1AD" modified="2024-05-29" version="1">MRRIIPRIPSTASALCSSSSPVASTSAAPLRALRAQATAAADSSSTCQSCNFSTQISATRNRVWQNTLQTQRRCASTVSETTPEAPVAAAAAEVATESTETVEQQRKRKGGFETPRQVNLVLPGQPTRADAPEKIRDPNYEPATSGAGLQEIGGMSDWWSKPEHFRDGGKQFEYQGFAPQEKITDPRLLKVILRRALVEGLALKKFGANPKNPADMVSIIGNGDHWQKTVAVEMCRGENGELSLKNHSDLQRVWILMRNAAEKADNTLEWQEQVRRLRSLGEKEQADQLLEEGKKLGYRLKGEEGSRVKLTVDEAIELRKSWNNDWKEATIRDPVVKFYAAKRIQKMTGHILSDGKLTSIQTVANFMDALVTPPKPKKLAEQIEQSSILPELPNVKVYPRRVTPVDKEKMVGRWKVIQKELQKRELPVLGTGNIGKYVELKWLGSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR95</accession>
    <name>A0AAE0MR95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation protein RMD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_278389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679940.1">
        <property type="nucleotide sequence ID" value="XM_062822842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR95"/>
    <dbReference type="GeneID" id="87859996"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="325"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3340998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="550" mass="61189" checksum="D7FBB4314EFF7403" modified="2024-05-29" version="1">MENTTASENTPLLPTTTPSSPDVARPARPQRNVTFNPNPVTKTIEPEAAYRQARASHPSLPHPPMSPSSSSAISTGGLGGGPPMLSALNGKLRRRNSGGAIGFNHNSGLPYTSAGNTHLPKIGPQRSTKNAQKLKLLPNPELEEDGVDEESGREVYSQYTRIKDPTARRDAARLGKADRDRLPRVTAYCTASRYQMDGLMRFLKSRSKSRGANPKLIDECIYTPYSYNPKQAAENNRVEAEAQEQQQLGLFDPIHSRRHSTGEVPQGDSSGYQSTEDLISLNLNGGSTSREGVQDMVAQGVISDENAVSDDPLADFDIQVHTPEVFLFEYGVVVIWGMSVAQEQRFLKEIAKFELEKLGPDDMETEYFNFYYTHEYQARIYNDFITLRDKNNYMTKLAISHALAQSVKTSLFEELIASTIETCKDIPTQIALTGKIDLSRQQINMQIGELFILRVNIHLNGSVLDTPELFWVEPQLEPLYKAVRSYLEMDQRVKLLTERMDVIADLLAVLKDQLTHGHGEKLEWIVIVLIAAEILVAAVNIVVDLYAGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRG9</accession>
    <name>A0AAE0MRG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_442446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681603.1">
        <property type="nucleotide sequence ID" value="XM_062825577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRG9"/>
    <dbReference type="GeneID" id="87862731"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="169" mass="18547" checksum="2FFF7981BAC3177B" modified="2024-05-29" version="1">MASDESYLAFLNKANEDPSVGYPRDRPDPATQKVGGNGFKTRDEGVALPSPIAKLLDKGDKFYVSDADEPFEGVALRFGEEVLPDEEKFASLINHPNPADAEIEISDPVDWDRNGQYTDLIDAVTEASEGRDVRVYRVVKDSVRVEYWVVSVSADGKLLVGVRALAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRL7</accession>
    <name>A0AAE0MRL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_523978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681366.1">
        <property type="nucleotide sequence ID" value="XM_062828812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRL7"/>
    <dbReference type="GeneID" id="87865966"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="220" mass="24023" checksum="94CC2BBBF31EB48E" modified="2024-05-29" version="1">MSSPARPNSPTLPPPPGPPPSSPLPLLPPFRLPSGTAKPTATDTARQQGALLGLLSCVCRVTETLYQDFRFLERRFGGDPVRAPKQQLEERRKRVRRVWKTVENYPGLALEGEVVRLCERMFGDVLRGEFPSDGGIAPPMLTTIFPLVYHPFINNGESTTTFMVPWGEYLGTFTGTISDVEEEVDKAVKKLTAKDRKTSGTGGGGDAGTGVRIESLMRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRN4</accession>
    <name>A0AAE0MRN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_427142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681411.1">
        <property type="nucleotide sequence ID" value="XM_062824666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRN4"/>
    <dbReference type="GeneID" id="87861820"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="202"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="703"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3344798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="862" mass="95298" checksum="DCEECFF1857F7040" modified="2024-05-29" version="1">MSQPYPDDDGHQQSQTTQAEEGISRYEERVDSGFLQRHDAPQSSKDKEEPLHRRKSPMPGRFYLGTSSSEDDERHSTGSESFYSYESMNSEQPFHLGESNPPVEESPPPLPMRDNTSAPRTASSPDPATIPISDEHARSSSSSFHEKPTTVEQPRGIPSQLLPRASSITSFGFIDDGEDTIISWEEDDPENPYNWSSGKKAAILFTAVMLILNSSMGSALPSNAIPFIVEEWKIESEQEKVLPISIYLIGYVMGPILWAPLSEQYGRRRLSIGTFAMFTGFTLACALAPHWISFIIFRLFSGIFASAPIALVPGIIADVYNEPRKRGRSMGIFMAVIFGPLIAPILSGYAATTIGWRWAFWIGLMYAGATLLPLFLFLPETYGPILLLQRARHLRSTNPNARVIAPRELEDNQHSLSELTSIVLTRPIRMILMEPIVSTSCAYISLCYAIFYMTFEAYPFIFIDLYGLSPGECGLTYLAIGVGCLIALPIFMTWDSILTRARQRNAAWTRQEEYRRLPLACLGGPMFVVSLFWLGFTARAEIPFWVPVLSGIPFGMGFMCVFQALLNYLTDAYEIFAASANAAASCSRSLLATVLPLATAPMFHRLGIWGACSLLGGMSLLMTMMPFIFLWQGEKIRRGSKFCLLLRERREEMERKIDEQRRRRTGVVSGVGSGAGFRFSAYGEGAARAETRGEGRVVVGAMGDIEEGNEGDEKDTGEMEKGREMEKGREMEKGKEMERKSLSGGSSHNEGGSQAEVAHGGTGDVVNHVNREYGADEVGESSKSFNHDHDPPPGSGSRSGSSATVAVSPPRMSATPDDGGSRMEMGLLEARKQARKEARKEAKKKARKEAKKEARKEVRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSL3</accession>
    <name>A0AAE0MSL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_204449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681994.1">
        <property type="nucleotide sequence ID" value="XM_062821846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSL3"/>
    <dbReference type="GeneID" id="87859000"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="102" mass="11629" checksum="54B3CF124C01332E" modified="2024-05-29" version="1">MMLKSLITTKSFDTKSLPESLSLSNSLPSYPSVLLCFLSFQLSVPLLHLVLNGSHARNTVEVSIRRIDPRKYVVIRYVLRLSLLFQNTIFAMSFLPNSRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTD5</accession>
    <name>A0AAE0MTD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">White collar 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_166481</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683196.1">
        <property type="nucleotide sequence ID" value="XM_062821304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTD5"/>
    <dbReference type="GeneID" id="87858458"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000063">
        <property type="entry name" value="White collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="558"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="695"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="917"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="286"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="903"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="951"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1001"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1076"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3348114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1137" mass="123483" checksum="F25F1BFC16C0D99D" modified="2024-05-29" version="1">MNNYYGSPLSPEELQHQMAAQHQQQQQHQQQQQHQQQHQQQQNTNQHRNAGMMNTPTTSGQGNNTIHASDVTMSGGSESLDEIFQQNLDEMHRRRSVPQPYGGQTDRRLSMLDYANPNDGFSDYQLDNMTGNYGDMTGAMGMPGHSGPYAGQNIMAMSDHTGGYSHMSSNVMGNMMTYPNLNMYHSPPIETPYSSTGLDTINTDFSMDMNLESGPVSTASVHPTPGLNKQDDKMMTVEQGFGGGDDANTPHQAQQNMGGLTPAMTPAMTPAMTPGISNFAQGMATPVSQDAASTPATTFQSPPLSATTRPIQIGPPPPPSVNNAPTPTPSTPSGGAASQAKSIYSKSGFDMLRALWYVASRKDPKLKLGAVDMSCAFVVCDVTLNDCPIIYVSDNFQNLTGYSRHEIVGRNCRFLQAPDGNVEAGTKREFVENNAVYTLKKTIAAGQEIQQSLINYRKGGKPFLNLLTMIPIPWDTEEIRYFIGFQIDLVECPDAIIGQEGNGPMQVNYTHSDIGQYIWTPPTQKQLEPADGQTLGVDDVSTLLQQCNSKGVASDWHKQSWDKMLLENADDVVHVLSLKGLFLYLSPACKKVLEYDASDLVGSSLSSICHPSDIVPVTRELKEAQQHTPVNIVFRIRRKNSGYTWFESHGTLFNEQGKGRKCIILVGRKRPVFALRRKDLELNGGIGDSEIWTKVSTSGMFLFVSSNVRSLLDLLPENLQGTSMQDLMRKESRAEFGRAIEKARKGKIVSCKHEVQNKRGQVLQAYTTFYPGDGGEGQRPTFLLAQTKLLKASSRALAPATVTTKSMSPGGVSLSAMQGVQTDSDSNTLMGGMNSKSGSSDSTGAMVSARSSAAPGQDTALDADNIFDELKTTRCTSWQYELRQMEKVNRMLAEELAQLLSNKKKRKRRKGGGNMVRDCANCHTRNTPEWRRGPSGNRDLCNSCGLRWAKQTGRVSPRTSSRGGNGDSVSKKSNSPSHSSPLHREVSKDSQSTTTTKNEPSLRGGSSTTPPGTVTTDSGPAVASSASGTGSTTISTSANSAASTVSALGPPATGPSGGSPTHHLPPHLQGTHLNAQAMQRIQQHQQLQQQQQQHQQHQFNPPQSQPLLEGGSGFRGSGMEMTSIREEMGEHQQGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTM3</accession>
    <name>A0AAE0MTM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H65DRAFT_163004</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683119.1">
        <property type="nucleotide sequence ID" value="XM_062821270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTM3"/>
    <dbReference type="SMR" id="A0AAE0MTM3"/>
    <dbReference type="GeneID" id="87858424"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="16">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3348037.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MTS6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0H65DRAFT_168357</name>
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    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821332.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87858486"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682805.1">
        <property type="nucleotide sequence ID" value="XM_062821119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU11"/>
    <dbReference type="GeneID" id="87858273"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="472" mass="51200" checksum="93855A3E7C4FC1D1" modified="2024-05-29" version="1">MTDADDQPSRLARSLLPEPTLSFTLPSLHDGLAIDCRVYHPQSLDPSPSSPPWRKHAAVFAHPYAPLGGCYDDPVVDIAAGTLLRLGFLVGTFNFRGAQGSAGRTSWTAKAEQADYTSFVGFLSYYVHFLDPFRPHVFEPVPTTTPIAEASDYMGPHGGSRPVTPSASHDTNKPSLFLMGGYSYGSMITMQLPSLETILHQFDTPACSSHAAEIRLRAQHLAEVQNTTLGSARAAALEHQANTLSHSPTGMRFGGEESSRKHHHSRLSFSHDTEEKIHKGVSELMAKAKSHKRRISGKDHSFVGGDAAHDTRETKQQPAKDCLPSVPDRVVARPAYLLVSPLQGLINNLATFSLLPRRPSWKGLTRSLSSPAATASPMGELGPDSETDLSLEEAEAKLVRNPTLAIYGDNDGFVPVRKLRPWATRLEGIPHSSFRAHEVSGASHFWAQGRSAYTLKDAIKTFAGSILATDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU98</accession>
    <name>A0AAE0MU98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_114236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684618.1">
        <property type="nucleotide sequence ID" value="XM_062820631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU98"/>
    <dbReference type="GeneID" id="87857785"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="123"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="599" mass="65680" checksum="5C96C0B14ABF0E94" modified="2024-05-29" version="1">MTNLLWSGYRSESVDDYPGVLVPLGEAHLHSHSSRSRPPSDLDDALLGQDDEGGHRHKDPADDEDTGMLLEMGTEPEYSIEGFRREVRRGNKGGEKWTDYEMKSKLINKAIQDIGMGRYNWQLFVLCGFGWFADNLWMQGISLTLPSLSAEFDISEKTVRYTTSFLFAGLCVGSFIWGIGSDVLGRRLAFNATLFITAIFGIASAFATSWAGVCFLYAALGFGVGGNLPVDGALFLEFLPDASSSLLTLLSIWWPIGQLCSSLLAWYFIGHLPAEQGWRHFVFSIGIITLIMFLVRFFIFHLYESPKFLLSRGRQAEAVAVVHGIAYRNGRKTWLTEEILDAVVDGLSSPSPATPRRRQHVTRQRLSTANILKQRFASFSGDRLRPLFSNRKLGLTTALIWFCWATIGMGYPLFNAFLPQYLSHGGNNSGQPAPEAETNNPEAISAETYRNYAITSIAGVPGSLLAAYAVDKKSPFLGRRGTLALSTLVSAIFLYLFVKFGTTPGALLTFSCIEAFAQNIMYGVLYAFTPEIFPAPVRGAGTGVASFLNRVTGLVAPILAATVPGDGTTTPVYLSAALILAAFVGMVMIPIETRGRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUM6</accession>
    <name>A0AAE0MUM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_506580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684411.1">
        <property type="nucleotide sequence ID" value="XM_062828071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUM6"/>
    <dbReference type="GeneID" id="87865225"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3351116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54977" checksum="391F1B635C1319A2" modified="2024-05-29" version="1">MKSFLDLLPVEMVDNIVKFLSTRDANSFAQTFIKKAVEAGADINAPDWLSCFHIPKRYNNDPNEWSLAKAASKDANGSPLHFAALTNNLEAAEYLLQKGATLHNTGLANWALNMCSCHYEDEDRVEPQGNYYEDYLALPLHTAVCHGSLEVAKLFLEHGASVHLHSIRRHLAEAAAKQNHPIKSNDNLLHVLVWKGPDYLASIDLIAQSPDTDINAEEAYSRPHNTVVIEKLAEFGAIETCDRHSESWIIEGCIYGCIHFGLYDNALALLKYCLHASDSEVGRLIRSDAVLLFAKAVTFNARLEEHHVKQVKQIIRMLVQDYGLELNTRLPHTCTEKDTPLEHLIVSSPMPEYLIQLLVDLGARLDIRNGEGHNPLVRCLWMEQSVTKAAQKTKARNKARKKGIREGAEAGSSGSSIIRQQTIRALIQACSWANIRIDEKYTWGKAELTLCRILEIRFPGWKPPEGLGNNRALWKDLVRHIEDSLELGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUQ5</accession>
    <name>A0AAE0MUQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_457167</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684501.1">
        <property type="nucleotide sequence ID" value="XM_062826338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUQ5"/>
    <dbReference type="GeneID" id="87863492"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000015">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="370"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3351206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="772" mass="85877" checksum="CDF8306DA179F98B" modified="2024-05-29" version="1">MFLASRVSHTHTFWDFGFSLCFLPQTNPSLPCYHTILPVRTSTTSASVMDHQSVFSARTYAGAASSYVPEEDSNQHIRAQLEAFILDFRLDNSFIYRDQLRENALLKKYYCDVNIGDLIKFNEEIAHRLVTEPAEIIPLFEAALKRCTHRIVFPNEPKIDLPDHQLLLHSNAEDVSIRNLDSLTISRLVRVPGIVIGASVMSSKATELHVQCRNCGHVQHVHVLGGFSGATLPRTCGRIRAPGDPGEKCPMDPYFVQHEKSRFVDQQIIKLQEAPDQVPVGELPRHVLISADRYLTNRVVPGSRCTVMGIFSIYQSGGNKKSTSGAVAIRTPYLRAVGIQTDIDQTAKGLAVFSEEEEQEFLELSRRPDLYNVMAECIAPSIYGNKDIKKAILCLLMGGSKKILPDGMRLRGDINVLMLGDPGTAKSQLLKFVEKVAPIAIYTSGKGSSAAGLTASVQRDASTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTILNARTSVLAAANPIFGRYDDMKTPGENIDFQTTILSRFDMIFIIKDEHERGRDERIAKHVMGIHMGGRGVEERIEAEIPVEKMRRYISYCRSRCAPRLSPEAAEKLSSHFVAIRKQVHASELEANARSSIPITVRQLEAIVRITESLAKLTLSPVATEKHVDEAIRLFLCSTMDAVNQGGSTGSNRELNEETSRVEAELKRRLPIGWSTSLATLRREMVEGKGFSEVALNRALMMLQRRDTIMFRNQGAQVYRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUQ7</accession>
    <name>A0AAE0MUQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_440579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685022.1">
        <property type="nucleotide sequence ID" value="XM_062825478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUQ7"/>
    <dbReference type="GeneID" id="87862632"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="207" mass="22948" checksum="935CF2E71F168912" modified="2024-05-29" version="1">MTPSSPSRHFGCSAVGNRAADEHDSRKTLEGRKNSWIPVAWKYLHLPPRMGRYNTPSVTSVCFFCASVLQFSATSFSSPTGHLPTTDRANKDQLDIVIRGNYHCAHRISTSSSLDDSHKQPRITRVPLARRLPWDTPRVYCGTWVASGDLTAATLSTQKVSQIPMEARTNQAIETITTPQYGCLTLNNAFVVITPKMGSRPPLLTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV77</accession>
    <name>A0AAE0MV77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_2353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685548.1">
        <property type="nucleotide sequence ID" value="XM_062822249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV77"/>
    <dbReference type="GeneID" id="87859403"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1746" evidence="2">
        <location>
            <begin position="65"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="348" mass="37842" checksum="3128905A580E1046" modified="2024-05-29" version="1">MNDDPEPSFAARQQQQRIPPHGPDDEQSTELNTSAQDDDEQTSRQEKRKAGLKKKLQFMSHLQRNLDMIFFAYLCTLYYMECSFLRLFVRIIPHFMFITPKEGPVLLPAERPHVFAILGPNLVCILAHIISALPTAGEATRGYLHGGVIVDFVGQKPPTTRLCPLFFDAVILAVQCLMLAIHTEREKLRKVVNPSLQPLWAGPGQVGQQTGASGSDGVRQPETTQTLDAEERGVNREDEIALGDGDGTETSPLVAEGRGGQEQDDEPRLGSNYSPASAGIDLFDVMRSGNASVGSFHPVHAIRTVGNDYQTAAAYTVQSLGFHAAAVAGNRGVRGIAGIANRAARRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVI8</accession>
    <name>A0AAE0MVI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_136269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685129.1">
        <property type="nucleotide sequence ID" value="XM_062820877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVI8"/>
    <dbReference type="GeneID" id="87858031"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF48">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="697" mass="76127" checksum="1C65FFBFF601202D" modified="2024-05-29" version="1">MVTNSEPASTGNLPAFSISLTQHPYTDHPFSRRYIVLDNQNPTLKIGRSSKLSAKGFVPSSQNGWYDSPVMSRQHAEIVADFAQKRLKLRDLGSLHGTYINENDQRLEKDDLVEIKDGDNIRFGVDIMRKKTFPPTIVKVGLEYIELTKAKPEPDTTRPRASSTFKVPDASDSDMEYQDEDSNIDPSMQGTQSAARGLAGRSWKGEVIDLTHPVGSGNVITNPQKQVIDLDQDDDYEINWCQSDEMDDIHQNNGSQSQPNIAFTQPPKSPIDSNDSNCSNCGSDGENVWPQNVGALQPTASQHPIASQYRAASYDDDWDSEMSSDYEPEYEPESAGSEVSGGNLGGDGDSSERGFEYDYPYSESDSDFSVGQDSDVESEAERVYGMEPSSNWAMPDLSNVVTGPTSKIEAEPNHDKGHGINRLVTPDISGDAINCNTSPINSASPVDMRSAAYPVDHPLFLSFTHPRDVQLATPKSNKSAGDTEAASPIHKPLNGPVAGTAEAPWYPSDKAEFFEARKENKVIVMQSSPVAREYSRLAISDIMDENAPVGKGKRKAEAISSSTEEELAWHASEVQKSEASGANEREEVMELMEVMEVDKDKEVGEPIESSTEDKEVNEPMEGSTEAATKIAVTVESLDLPVSVATSTVRLNDDDSDRPAKRQRLRNIAERVGYVALGGVATGAMMFGALVYTAPTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVT1</accession>
    <name>A0AAE0MVT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_438076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686148.1">
        <property type="nucleotide sequence ID" value="XM_062825348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVT1"/>
    <dbReference type="GeneID" id="87862502"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15102" checksum="522F04BFCA8EDBD9" modified="2024-05-29" version="1">MPRQSRGSARPSVPARKPMAPTNQQQQRPASTYAPPTAAPHAPPAAAAPVSQGPGLFGQMASTAAGVAIGSSIGHAIGGMFSGGGSSAAPEAAAPVQAQAAAAQNSSWGNNCSEATKSFTQCMDQQNGNMQICGWYLEQLKACQAAASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWG7</accession>
    <name>A0AAE0MWG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase Rpc34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_47773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686808.1">
        <property type="nucleotide sequence ID" value="XM_062827443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWG7"/>
    <dbReference type="GeneID" id="87864597"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3355430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="416" mass="45850" checksum="C35DDD170840AA3A" modified="2024-05-29" version="1">MADRDKIQILKDALYEAARDHGSDQRLFTQRDLMDMQVIPQDNIGLLIQVIQILCDEKLFVGNTTASGLSWRWRSREDAKKYTSLPNSETMMVYAMVDEAGADGIWNRTIKNKLNMADHLMKQCIKYLEQKGYIASMKNVEHPNKKMYIKANLRPSDRATGGPWFTEGELDTAFINELQEIVFDFIKQKSTYTSHGGAGVGTTGAAAGAQQREKIPKKGVVQGTIPHSEDVSKGTKRSAGEISNDDTAAAAAAAPATTTTAKKTRPGKPQLLPLPAGYKSYPTVSDIAKFIHHAGITNNTTLSEADIQQLVDVLYYDGLVEPVKVNGRKGYRVTRIPKQDPRTCNQRRLDHDPTKGGVVTSFMGVEPSASGLMEAPCGRCPVYDMCEEGGPVSPSNCVYFKQWLDGDEVKEQVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWM0</accession>
    <name>A0AAE0MWM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_54401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687032.1">
        <property type="nucleotide sequence ID" value="XM_062829265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWM0"/>
    <dbReference type="GeneID" id="87866419"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="542" mass="59744" checksum="BFA61BDA0474D57C" modified="2024-05-29" version="1">MSTPTSPPISPLLFSAQLYPGRALGWLVLGASLHDVLTRLKTEPQRFPNLDVKYSPTSPTTSIIIIDLPANGMRLQFDAPEQRLRLIEVLDFTKNHIFLKAADNKERDLVRPSTASTLSTDNAAGPTFRHIYQRFLGPTYDGEFVDGPKTPDNAVDQYGLYCLSWPGVAFTFLMKKEAYSAKKNVVDLLPSTAVPEVMGIFSGDSWTQARQTLWTDVLPSLKTFTPLTKGKEVFPDEVSLIKIYGAGKLQVFRKWTDQHFWIRLGQTTPQDLVSHLGPPDAIYRKSDHKMFAHNTRTGSDAMKRPDSADLKHQDDLTDTDQSSANAGSDGYHSSDDETSDISTEGGHVSGECFYNYFSHGFDVLVSKPTAPSPVPPSQEQGKNVPNVPKDWLLTANADSLVATKIVLHGNVPGSYPFNRHRRCRWEIPYLSSVSDVVINSESDFPQIEESLRKEWQSLYPSEEEARKAQRGMVLNRGWGDSPGSSIEFLGGWEGDGATAAPDAGGTAKKFDGPADSTTTLYGFPGFVFEVLKNGAVTAVTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWT0</accession>
    <name>A0AAE0MWT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_10632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685760.1">
        <property type="nucleotide sequence ID" value="XM_062820490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWT0"/>
    <dbReference type="GeneID" id="87857644"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="71" mass="8773" checksum="24FB2A6F0EBB9E30" modified="2024-05-29" version="1">MCDYIQREYACRHMRWIASHWCREYTITHKRCKPNVAHFEQKDIDCGECKSRQRGAVPWEHMIRRDKSQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWU9</accession>
    <name>A0AAE0MWU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_555226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687272.1">
        <property type="nucleotide sequence ID" value="XM_062830017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWU9"/>
    <dbReference type="GeneID" id="87867171"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="791"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3355894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1215" mass="135366" checksum="526EFBB4A0250341" modified="2024-05-29" version="1">MSDSDFEQIKKLQQERNAAAAAKNGSRTFDPANQRSDNTTKAKMGEVWDTGLYERDNGDKFAGYHTTLPAADGEDEDMEDADSGRRLVGQYTATRTQIDEFARGDGVEEDDPLAGRGEKSNRITDRETDYQKRRFDRVLTPTRADPFAANRQAGAAEDGESYREIMERRELEREEERVRRAIEQKMKEGGPVEEHQPTLKDSGDKENEEAGSTEAAAGRKRKKRWDVASTEDATPAPEPKKRSRWDQAPSVPAPGAPGAETKKRSRWDQAPSATPVGNVGLATPMHPTQTAVVQPVFGTDAAGRYAPLSDEELDAMLPGPEQGYKILDPPPGYAPVRAPAHKLMQAPAPTTGFMMQEPDSGRMTGQQVPKEIPGVGDLQFFKPEDMAYFGKLTDGADEESLSVEELKERKIMRLLLKVKNGTPPMRKTALRQLTDNARNFGAGPLFNQILPLLMEKTLEDQERHLLVKVIDRILYKLDDMVRPYVHKILVVIEPLLIDQDYYARVEGREIISNLSKAAGLATMISVMRPDIDHVDEYVRNTTARAFAVVASALGIPALLPFLRAVCRSKKSWQARHTGVKIVQQIPILMGCAVLPHLKQLVDCIGPNLNDEQTKVRTVTSLAIAALAEASNPYGIESFDDILNPLWTGARKQRGKGLAGFLKAVGYIIPLMDEDYANYYTSQIMEILLREFASPDEEMKKVVLKVISQCAATDGVTAGYLKEHVLDEFFKSFWVRRMALDKRNYRQVVETTVDIGQKVGVSEILERIVANLKDESEAYRKMTVETVEKIVASLGAADIGERLEERLIDGILHAFQEQSVEDIVMLNGFGSVVNALGTRCKPYLPQIVSTILWRLNNKSATVRQQAADLISRIAMVMKQCGEDALMGKLGIVLYEYLGEEYPEVLGSILGALRSIVTVVGISQMQPPIKDLLPRLTPILRNRHEKVQENTIDLVGRIADRGPESVNAREWMRICFELLDMLKAHKKGIRRAANNTFGFIAKAIGPQDVLATLLNNLRVQERQSRVNTAVAIGIVAETCAPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMAKDYVYAVTPLLEDALIDRDQVHRQTAASVVKHIALGVVGLGCEDAMVHLLNLLYPNLFETSPHVIDRIVEAIEAIRMAVGPGLVLNYVWAGLFHPARKVRTPYWRLYNDAYVQCADAMVPYYPNLIEEGIDRTELAIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MY41</accession>
    <name>A0AAE0MY41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_585399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687155.1">
        <property type="nucleotide sequence ID" value="XM_062830925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MY41"/>
    <dbReference type="GeneID" id="87868079"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="145" mass="16328" checksum="7D9BB824BBD3EE27" modified="2024-05-29" version="1">MSDFPKDTKPFERNAYRGSGYSNTMRNKSKQAYRPKQRGGSQSQHSRNPAKASTSSSGQQAPDADVPHFMTDAEVKQWFKEAEEEYEADKKAGRFDTYELAGGVAPDFSKFKQEFDADGKPFKGLKNSMHAVKVPEADDDQHQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZT1</accession>
    <name>A0AAE0IZT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_553678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676497.1">
        <property type="nucleotide sequence ID" value="XM_062829986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZT1"/>
    <dbReference type="GeneID" id="87867140"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3334331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="211" mass="23315" checksum="2BEDE6E128EF3161" modified="2024-05-29" version="1">MSHSHLNPEATPFLPAITSLPTLPDAALISTLDLLFEPSPELHALALPTLRTISFSSYPDLISTIRDELLAIANAVADPSVPETEKENIKRPLHAILGSHPRLGEPKKETLSAQSKKEQAHLNAAGDSEEVKEDLRKLNKQYEETFPGLRYVVWVNGRPRTEIMVDMRTRIVRGDLRAEEREGIKAMCDIAADRAAKLLKSAQEAVEHSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0Q0</accession>
    <name>A0AAE0J0Q0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_481737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676573.1">
        <property type="nucleotide sequence ID" value="XM_062827638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0Q0"/>
    <dbReference type="GeneID" id="87864792"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="450" mass="49861" checksum="B2E1BE3B7C57E743" modified="2024-05-29" version="1">MSVEAGDVETLPIDGWKVPFFVAYDEETLAKPPDSSHPDLKSKWAELEPGKYSLSRIIMFLGSAPLSSLDWDHAHSPGLSKDSDPDDMKVMFFKMFLTAYLKRLQKDPDALTLGYTIKEAAPDPTDKAPTFPPTAVKIQNYRYQPCSDTQQTINGKAIPPNSRDAFVFMEMTGGSDFPRDELQRKGNLIIGDMPGALVFNRELFFKKYLVENALSTVNVSFLDMANDLMKWVDGGRWESDWLLTNGSRAEAIPDAKWTIDGSKAKLSWKGNKWFSSIGVHRSTDSSLETELSTQPRTNKITLTSKMKLGSSMTVVAGRGPGYNRGTDGEVHLTIEFVILADEDGTLHVQPEEKIDYVGAEDSRDASLIKLIFGKPSTEVGDFIKGKLKDVVRTKHIGDAIAADLNEKKQLVFPGSGTFSYKDPKFSDGGDLLITLDLVGKDIERDRTLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0R6</accession>
    <name>A0AAE0J0R6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome component C5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_533735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676905.1">
        <property type="nucleotide sequence ID" value="XM_062828986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0R6"/>
    <dbReference type="GeneID" id="87866140"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3334739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="265" mass="29191" checksum="011B60CAD5CBAA0B" modified="2024-05-29" version="1">MAAMFSQNPLMNGPNYSFNDAPRTAAPEGARQHRFDPYTDNGGSTLAIAGADFTIMAGDTRLTSGYSINSRYHPKLFKIGGTTADQKDATIVLSVVGFMADGEALKERLDAICKMYRYRHGKPMSVKACAQRLSTILYQKRFFPYYVYAILGGLDEEGKGAVYSYDPVGSYEREQCRAGGAAASLIMPFLDSQVNFKNQYEPGSGVGHALQERERKPLTRFEGEILAKDAFDGAVERHIEVGDGLQMMVITKDGIEEVLLPLKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0U2</accession>
    <name>A0AAE0J0U2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_436784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676756.1">
        <property type="nucleotide sequence ID" value="XM_062825260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0U2"/>
    <dbReference type="GeneID" id="87862414"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="52" mass="5981" checksum="B4B652EDCA3EE96F" modified="2024-05-29" version="1">MAKRALVTERLMRGEWTCSGRYCGVVEQPNTVCAACRQRSRDYRQSLTEAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J1R0</accession>
    <name>A0AAE0J1R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WASP-like pretein las17p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_337910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677098.1">
        <property type="nucleotide sequence ID" value="XM_062823597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J1R0"/>
    <dbReference type="GeneID" id="87860751"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="636"/>
        </location>
    </feature>
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            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
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            <end position="327"/>
        </location>
    </feature>
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        </location>
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            <begin position="370"/>
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        </location>
    </feature>
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            <begin position="566"/>
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        </location>
    </feature>
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            <begin position="588"/>
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        </location>
    </feature>
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            <begin position="627"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3334932.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="636" mass="66094" checksum="ABD36329E6536D13" modified="2024-05-29" version="1">MPSILSDDDKETVKRCVPKQTNKIHAVAVARLYVAYPNPSKWTYTGLQGAVVLANDLVGNTYWIKLVDISPGNRGVIWDQEIFDTWSYNQDRVFFHTFELEECVAGLSFVDEKEAKQFLKKMNDREKNASKATSKTPFGGASQAHHHKHGLFGGLFGGHKHSSPTATPPESPRTAAPASRMSGMNGYKPPSEFATLDAFDPLWREHFGDDLKAQGLDDDFIRENQDFIIEFLKQEQAKQGTHTSTPPPPPPSAPPGGPAMRAPPPPPPGAPRPVSESVTPSTSRRGPAPPPPPPARRSGKLDTENHQEPTPTRDSPPRPRFSVPPPIADAGKFAHSDPPRHTPSAPGPPPPPRPPKTPLEDSDPGHRFGVPPPFTGQRSVPPPPPSRGSVPPPPPPRNSAAPPPMPPRAPGPAPPLPPASSRPPPMLPTRSPAPPQAPPLPTSNAPPPPPLPATQAPPPPPLPATSAPPPPPPAPPAPPAPPLPAAHAPPPPPPMPPMPAPSGGAPPPPPPPPPPPGGMGGVPPPPPPPPPGGMPPPPAAALPPVDGTRSAVLDSIKGAGGIRALKKVDRSLVRDRSAAAVPGGGSDTGPAGSGLPPAGVAPGGGGGMADALALALQKRKEKVSRSDDEDDGDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0J1X6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_512839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062828608.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87865762"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="215"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="227" mass="24981" checksum="526195C968CFBE00" modified="2024-05-29" version="1">MSSPSSNSRQSQMRNNQPPCLQASAASRSQSIAEEAARLTAVTNQVIATFNRNEGARIPAVTNQAMATFDPNNFIESMDAALNAMRAVAGGEPHRVRRIRRIAHDIANVYERNSHLSRGRRHPRNPENGIPNPPPPYTALPSKGEVTIEMALPEPEYTPHYTPSGQGQKRKREEEVENEEDDDVEEEYHGFIRSSAPSPEPTVPQRATRCPGFAVEDDGDVSDEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J2I7</accession>
    <name>A0AAE0J2I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_480690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3335031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677197.1">
        <property type="nucleotide sequence ID" value="XM_062827596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J2I7"/>
    <dbReference type="GeneID" id="87864750"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3335031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="214" mass="23227" checksum="9B940F670BFE75CE" modified="2024-05-29" version="1">MRQDKHLALHRRWALGRWEKRTMDACLRHTAPDCKCSGSHELKAFHFSLLRLKLLCHVSSQSQTPFSYSFPHSSHSAVSPGRYQPSLPPFLPILPLSFPFQLAFQSFTSPLSLTQFLLAPAPALALALLLPVPAVVPAVHVVTVLLLLLSRARNFRTLATLGTLTGRLRRRLNRPNGLGIAARAVVRGVGGIIAVVGVDDAVVVVVSGGRHCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J6J9</accession>
    <name>A0AAE0J6J9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_511838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3337886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677337.1">
        <property type="nucleotide sequence ID" value="XM_062828528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J6J9"/>
    <dbReference type="GeneID" id="87865682"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3337886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="311" mass="33779" checksum="090B858A85D5D44F" modified="2024-05-29" version="1">MSSPPPCRQRRRLVGVSTKMYFSHARTTKFITSFLDLMQHHTSSTTTEQSNSNLAAAALASKIDIFIIPDHLSLQSAINCTANHPPTDGPKILFGAQNCHWEDHGEVSPAVLAEIGCSVVELNHAERRRYFGETDATTAKKAQAVIRNGMIPILCVGEGSPGEVPTPGKTSREAAEKEVVGQVERCLEGVDPTKEVWLAYEPVWAIGAKEPAGVEHVSGVVRAIRRSAVVNGREERGGMTRILYGGSAGPGLFGRLKEEDGVDGLFLGRFGHEEGQFWKTVREVAEVEWEGEVRLGGCQSAGRSCRSPVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J889</accession>
    <name>A0AAE0J889_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_319025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677786.1">
        <property type="nucleotide sequence ID" value="XM_062823391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J889"/>
    <dbReference type="GeneID" id="87860545"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000004">
        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041929968" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3338335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="177" mass="19274" checksum="A78A21DDE751C0E6" modified="2024-05-29" version="1">MRLSAAVIALLSTSATALSVFRENSVSTNGELDVPGKSPLRFCDAAADRKDDIIIIEEVVLTPNPPEAGQTLTIEASGIVKEAIEEGAYVNLQVKYGYIRLINTSADLCKEMKNVELDCPIEKGRISITKNVDLPKEIPPGKYTVEADVYNSDDKHITCLTATVIFPRKGLGFFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8I7</accession>
    <name>A0AAE0J8I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_446321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677921.1">
        <property type="nucleotide sequence ID" value="XM_062825792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8I7"/>
    <dbReference type="GeneID" id="87862946"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="250" mass="28209" checksum="4D950D1439D23BBC" modified="2024-05-29" version="1">MAERIVDAVEEAYKYRDEGVAPPSSNHGGPACGTHETQLPISSHAVCRNLKKILTSLEDGKIVGRMPYIPPLAVWGAIAVLELWQKRGPNSKRNKHMEAPRDVTSGVPIPQLDKNFDYYVNTKKKTPNTAKLDEKDPFWYTMGDKRDFIMPNKRRYPDGAFPEWQPNAQGISWKLPNDISKDWAWPTSANLCCLTSQHDHTEESVFRPDKRTIIRPRDFADGGKFRSIVKISMRYEGEAGPTAGRSAPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8J6</accession>
    <name>A0AAE0J8J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine-specific methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_288447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678402.1">
        <property type="nucleotide sequence ID" value="XM_062822976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8J6"/>
    <dbReference type="GeneID" id="87860130"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF2">
        <property type="entry name" value="HISTIDINE-SPECIFIC METHYLTRANSFERASE SAM-DEPENDENT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="87"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3339042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="444" mass="49154" checksum="C3014D3C8C854976" modified="2024-05-29" version="1">MAQVLPSPGVESHPFHQNTKDGNVSSFSPGAPSSMSVPRTLPSLLYHHHHHQHHHLSTPSSSNTSSASDMLDIRSSSTSLLDTLDTQTLSSLLQPPGRKSLPSLLLWDEKGQSLYDSILATPSYYPYRVENALLQKQIGHIASTIASSTTDILVELGAGNLSKTALLLSALDQCLEDSSSSGSSRAGLKKMVYYALDVDHTLLSSSLHQLRKHTAPALKNIELRSLLGTYEDGARWLSQPDLAPYRKTMVWLGNSIANYEKDEASDLLAKFTTCSQNGYGMQNLAGFLLGVDGCLDQEKVERAYNAPGGENRRWVLHALEAAGEQLQLQPRDSDMFDEKNWKFEGRWDGERQRYENYLVPKRKLEAVVTCKGGKKVPLVLEEGEKVFVLGSGKWTARDVQGICEGPGLKLKKSWHSEGDDYGVYWLQPGKKRLDSGIEMEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J8L1</accession>
    <name>A0AAE0J8L1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_287819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678383.1">
        <property type="nucleotide sequence ID" value="XM_062822969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J8L1"/>
    <dbReference type="GeneID" id="87860123"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055916">
        <property type="entry name" value="DUF7493"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24321">
        <property type="entry name" value="DUF7493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="170"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3339023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="559" mass="60612" checksum="6A3FCC8BF5F4D7F9" modified="2024-05-29" version="1">MGDVRQLQDEHAAAIAKASAQEPSIQALTSQATTSASGKNVNILELPAVTLTCEKDELVIQEHAAATKKSRSCCSVTPPRRLPPGSVPFYNILWAYITPDRNYLCIDFAEETSPKKHQLIVRQLEFPLPSATSHEREPLLSPPSIPPPSAATLDAFVARVLDLAYPSPIQRRKRAWVLVNPQAGPGGADKIFEKKVRPIFEAARMPLTVIRTTYSGEAVTLAQDLDISGYDIAVPCSGDGLPHEVFNGLSERPDAKRALSKVAVCHIPCGSGNAMSCNLYGTHRPSLAALAIVKGVPTKLDLCSVTLQDGERLTSFLSQAYGLIADLDITTEHLRWMGAARFTYGFLTLAIRKKTYPCDVAMKVEVVGKEEIRGHYARGVKGAESEVGNGEASGEGEGEGEGDGMPGLKYGTVNDKLPEDWEVVPHEKLGSFYCGNMAYMAPDANFFSAALANDGLLDVITTDGDISLWKNINLQLGVESGHFFDNPLVSYRKVSAFRLTPRYQDPNGVISIDGEARPFAPFQVEVHKGLGLTLSKRGVFEAPGPHGWDEVTTTERLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J914</accession>
    <name>A0AAE0J914_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Norsolorinic acid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_294044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678594.1">
        <property type="nucleotide sequence ID" value="XM_062823051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J914"/>
    <dbReference type="GeneID" id="87860205"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19146">
        <property type="entry name" value="AKR_AKR9A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3339234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="380" mass="42441" checksum="B4AE6A249CA56F87" modified="2024-05-29" version="1">MALPMAPPPKSPLGRYRLLSPTASVRVSPLCLGAMNFGDAWQDYMGACNQETTESILDFYYENGGNFIDTANNYQKEESEKWIGEWMKKWGNRDELVIATKYTTNFRAGYGETEIMANFGGNGTKSMRTSVEASLKKLQTDYIDLLYVHWWDFTTSIPELMQSLNQLVTSGKVLYLGVSDTPAWVVSKANQYARDHALRQFCVYQGRWSAASRDFEREIIPMCREEGMGLAPWGALGGGSFKSEEQRQQQANDGRKIKATEEQIKISRALEKIAQRKNTAITSVALAYVMHKAPYVFPIVGGRSVEHLKGNIEALKLALSAQDIEEIEGAVPFDIGFPNSFLYGEKVPAHPSQVWLMGMAGTYDYVPVPKPIVPTAEDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J918</accession>
    <name>A0AAE0J918_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_582523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GLYK kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677917.1">
        <property type="nucleotide sequence ID" value="XM_062830853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J918"/>
    <dbReference type="GeneID" id="87868007"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3338466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="320" mass="36203" checksum="A0836B75FDBE4283" modified="2024-05-29" version="1" fragment="single">MMDTIDSISSTSTSTSTSGTADPTPELQSRIIDDKSPLCIPFIFSKIAEYNALHANEANPRPFIIGLNGVQGVGKTTLVKALAETLQEREGLNTLVVSIDDFYLTHEDQLRLAEENSDNALVQYRGEPGTHDIPLLLSFLHSLTHHLPTHLPHYDKSAHHGLGDRLPPSTFPPINDPTLSQPQHTNIRVLLLEGWLTGFRSLPPSVISSKYLDLKSYKTLSHHKLEHLLFINSQLQKYEQVWDQFDAFIHIDAQELGWVYEWRLEQEEQLRREKGTGMSGEMVRRFVDGQGVFRGDETKKGRQLRIVVGRNRGVVEHMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J972</accession>
    <name>A0AAE0J972_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_432557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678313.1">
        <property type="nucleotide sequence ID" value="XM_062825011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J972"/>
    <dbReference type="GeneID" id="87862165"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="313" mass="32438" checksum="0EC2ADB747EEF3F3" modified="2024-05-29" version="1">MEQPQVKMIGGREYAATGSKFGPSYLPVDVMARMNASPHQGLAMSAVVHDKRSLDSEAPAREPLPGVDTDKHLTMPSPKRGPVASTFRPLPKISKANGQGSVHSLSLPVSIANSPAEAAMAHLINTLVDSAKATFEDLLANMAGSASNTVNSGSDSGAADNDNGNDKGNGDGSGDGAASSSTTTTAANTTSATGSNIGTPRRRRAAGGGSGGSGRKPGGTPRKKPASRADVIEKRGSCERCKKSKAKCEPIPECIRCAKDGVECSLKETMMQETGRRLGACQRCKKNKVGCKKIESCGRCHKAEQPCSWAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9F8</accession>
    <name>A0AAE0J9F8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_476731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678884.1">
        <property type="nucleotide sequence ID" value="XM_062827388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9F8"/>
    <dbReference type="GeneID" id="87864542"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3339524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="321" mass="34263" checksum="F0155F17DB4EC6C0" modified="2024-05-29" version="1">MSSIKRESSDRRSTMSTPATSHPKPDRETLTSTVSTAPTTLTTNPDPNPSQLLDLPTLTDTLPQLAHKLSALAAVISRGESIALATGRSSTVTVAEHHSIPGASTLSLAEVAELQTCRKAIDTSAEVQARVRSEVRRLTKEIHECSEVIRSRLVSLQAKNPKSKHYGKEFKGPERAGGGRSESNIPARAGAPVSIGSQLSSSGTELIPKVHGRSRGDLLRGTHLEGVRNSVSTLEGNAANGEDVRLSPSPPQGHRSSATSGQPSPRHYLGDVEQSENRGVLGEKGEQLEGYSCSQGRRHSGVSEQGRRARICCIFLLHNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J9V2</accession>
    <name>A0AAE0J9V2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0H65DRAFT_542086</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3339341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678701.1">
        <property type="nucleotide sequence ID" value="XM_062829198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J9V2"/>
    <dbReference type="GeneID" id="87866352"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000004">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000037">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000003">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="22">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="20">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3339341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="647" mass="72558" checksum="E8A9451DC3184E3C" modified="2024-05-29" version="1">MSWRKDEDERPDGDEGDEELDENDYKTQKDAVLFAIDVSKSMLKPPQAMGDKKADKDSALTAALKCAYQIMQRRIISQPRDMMGVLLFGTEKSKFRDDSGNGTGYPHCYLLSDLDIPGAEDVKKLKALVEDDEDEDEIMVPSKEPVVMSNMLFCANQVFTTNAANFGSRRLFIVTDNDDPHAGDKQAKSSAAVRAKDLYDLGVVIELFPISREDKKFDLSKFYDDIIYRDPAAEAGQSEGPKTSKSGDGLTLLNSLISNINSKQTPKRSYFSNLPFELAPGITISVKGYIPLHRQTPSRSCYVYEGEEQAQVVQSETAQVDFAARTVEKSELRKGYKFGGEHICFKPEELAELKQMGKKTLRIIGFKKRSKIPSWASVKKSVFIFPSEEQYVGSTRVFSALWQKLLKDDKVGIAWFVARENAHPVMVAIFPSGNPDNEEANTPYLPAGLWLCPLPFADDVRSVDHVTAPARPADELTDQMRQVIQNLQLPKAMYDPRKYPNPSLQWHYKILQAKALDEETPNSMDDLTLPKYRQIDKRVGGYLAEWKEMLAQKARDLQNNRAFKREFEDGDDERPAKRAKPTKKATNGGGAGPANSNADLKKAHEQGTLGKMTVAELKDIMASKGISTAGRKAELVERLEQWVEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JAL2</accession>
    <name>A0AAE0JAL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_258288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679350.1">
        <property type="nucleotide sequence ID" value="XM_062822584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JAL2"/>
    <dbReference type="GeneID" id="87859738"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="700"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="813"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3340408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="94064" checksum="5CB741534C08A17B" modified="2024-05-29" version="1">MLKMDSEDGEFFIKQLASFVRTHEKALANALQFRRQNTPRHASSQSVSVLSTSAPTASSLPERPSTSSSPSSTLAAALSLGSLNFTSHNVKSAKLALTAHHLFYLLSRFEELAIPVGPMKVRLENLHDNRNSGNYVSFLSQTQRSKSRGSDVGSIHSVSSIRSVMSGMSALWSSFGIGSSISAARSEKQKAAIQADLKYLYSAFTKIPCLRLAPDFRARLIKGYEEFPFDSAVPLYVFKNVQALEVSDTDFRQFFGWDRLAEQLRSLTLKRASLDDPADVLIDIVLDDMDKRRRRSSKAQSSLTGPWSAPSPRRSPTIPQAAQKSNSPPSSPDARTSNTEIPVGSLNSESGPDQLGAALHNHRRPSVVRVDSDESRTPAKDGRPRSHSPRRPTSSRNGSSNVRGNHKIRRSGSGSSHSSLSDSWYNSRGSSSNLLAMGTLPPSKWRFLKHLSLADNSLASIPAASLGPLANTLHSLDLSANLFTQIPDSLATLTALRALNLAHCMIDSLHSLIRCPLPAITALNLRANRLTSIVGIEKLYPLERLDLRDNQIADPMELARLTGIPELREIYVEGNPFTRTHRDYRITIFNLFRQTPGYTEDITIDGSGPSYSERRYLVERAAEPPAVPVIKPAPQELPAVDVSKPAFVYEPPPREPAVLRKERPMPKSASSELNTASTRRRKAPKRRIVDLATNETPAPVTLVDNRNRPGDRAASGHNEHYRISQPTEVHAPQETLAASPLPDARAPADIPRIESTVIPSIPPLYPSHKGSSESQSWRDNDNWDIDGELYRRKIESLRDKVGSRYLSALNEEGWDHTSLPPNYREGNFGAPSPLLADPTAPRAASVQAIHSGRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JB17</accession>
    <name>A0AAE0JB17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_551110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679620.1">
        <property type="nucleotide sequence ID" value="XM_062829785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JB17"/>
    <dbReference type="GeneID" id="87866939"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3340678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="585" mass="65834" checksum="B8129726E7274D9C" modified="2024-05-29" version="1">MANSKKTARGKPTAAKQKTAEPIATTKAVAPADPTATTDPDATTEPAAPAKPVVAPVNADGEYEVVDELKTIKAYADDHKGIPSHWDVKAIKAARIKFRKGDGVMLKDQLMPYFPEPSIWASMYEEDWCLISYVMGFKPAKGLRLAKNPFNDMKWREQFMEPPINMLKAVRIPVLKKSFNFDVFPRNEVFAEPLPLDEWWYIEGPKFVWHWDGVKATKSSRVTRSTPTAVKKEKASDEVINTKTGENESSSNVDATKPAASKDVAISTETGESKNTINVDVTKPAASKDVAIKTETGKSKIDVTKPAGLKDIAVTTGTETINIDTTISDPVVKQQADKPLITIPNDVIEIIDSDLEWEPPVNIADEVVTVASMNKPFFDFAAVTKKEMKDYVDAAMDGLPNEDDINAEIEKIGRGMKKLKRKYREMEKKNEDLEEECKELNEKLGAALQRITELEGREAKRQKVADMEQKEIEEEQPEKKRLKEEELEKKRLEEQRLEEERLEEQKLEDAKKLEAKVVGRNPNAFITDEVAQRMERQEKQINVDDGHLIVKHGLYSFFYGDGVVVRWVGKPNNVRNGVWVPARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBF5</accession>
    <name>A0AAE0JBF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_272879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679778.1">
        <property type="nucleotide sequence ID" value="XM_062822766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JBF5"/>
    <dbReference type="GeneID" id="87859920"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001444">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="519"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="653"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3340836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="708" mass="80356" checksum="74C7DE6A0F01B27E" modified="2024-05-29" version="1">MSRVANKTKVRKYGKPTTKSRAELLFAELPKTPVKQPCRRPASQILGPEPFQISEPVITESVPAYHEQKAKPSPEAEPESVPKPEPMSDEDDVHDVTEHFDSILLDEEDDHQDAPYASTPRPSIGSYTSYNTSVPPPPQQRQQQQPPPPSRTSLSSQPPRLSPFRKLASPSVQSPATLQPPTTNSPFGRSPFPLKSPRVRQLIQEESNQPQYQQQDEQKQEYSFYDTSSFHTLSWSDICGPPSALNSITKIAEASYAEVYRITNARGISIIKVIRLQSPIRPQTKAQIKSGLVDEEAHAESDLQGELKISEWLADIPGFVIYKERFIVEGKGTKELLETHQVFQRKMKRKDPGRAQFYPSPSRYLESTRFLVVELGDAGTALEDFMAQPEQKMTWTGEMLWDVFLSTAVAMARAEGEVRFEHRDLHEGNLCVRRVRGARQKEKKPSDEEEGRGDGGGAKFGWSGLEVTILDYGLSRATDPETIGPDLELCPASPIGRRTTTDREVKEEAVVFYDLERDPSMFTSTHAPQCDIYRRMRAYLLSNTPEGKPVSWAGYYPYTNVLWLSYIYSYLCQHFKGDKRELEAWREETEEMWKYLDPKQADAVRQEGSIGFGVAGDVVGFAVEKGWITEAQVMDVGDRSTVLFEESRLEVPPMEGIKSGGEKAITESVENQQAGERIESWDEDEEDDQIRRHSKRRRTRRRYVDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JBY9</accession>
    <name>A0AAE0JBY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_216769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680115.1">
        <property type="nucleotide sequence ID" value="XM_062822000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87859154"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1824"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1398"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1832"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1947"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1967"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1979"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2016"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2059"/>
            <end position="2078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="2135" mass="232359" checksum="3EB5FF601FBF7C32" modified="2024-05-29" version="1">MAVKGATEALVAAFTFGLVLYAATAALALYAKGHGTAILRDGQRLVLVGFLSTAALWALSDFISILLKVDNSSTHCQIGIIFATIFDQLARFSIEQYLHWAQNTGEKVSAVQIIAQLLILGRLVAGGVFVGFTRPQTDSFCVAASSELPISIAVISMDAAIFFCLISRALAQNTQLNTESQDARRKALFWVMFGLAVWIATSVTLHLGFRYVALVVRTALPAIGLTILIIILTVCSGTLGSASMLRSKSPEALSPRRVEISRDISSSDPYFPGGNYQDVKDAAIRSETAFINPREAPATNNQPTYGLPTISLPITGVAGMGGVPIEGQLFPPIRANTAPTVRRNRSVKAAVGLHKGSLHKKGASAGARLQISNPILQDTGKSPLDKIPTVDLQDAMRAERERREKLLRQTSQAKREMNMQPSAMDPREGVNRAVSLKRKEVGSPVSSGSSLRPENMGMSSSTQLSPGTSGIRQRSPRQSPKPSEASRQSTFPSRSVSPPEDFEQPLPNLDIRPSRQLPPSPPAPPQERPLTVLQRRPTTGLPSNPKSRALNLEQDAPGAERQQTVLFLNNVIYDDPALVHDILQGSDDRTINKPQSPGTPESVVHRPRPIPRKVADPNPFAGHRRSKSSGSLVKKSVYMSEDMPPPPAPPKSAGAGTRPQPNRTRSMTVTEKIARMYPGEMPNKMPPVPEVPAVASSYLQSPSSVDSEEVRQPSQPTKTTAKTENISTIVEESRNGTESKYETDMAAKRASSPVIPVNPPRESMYSEGSQSPDEADTTWSSVRYTQVTVGLAVAQPMPRPVVKTVRQESETKLQPEVPPASQEPAKEVKRPEVNTAVVNKPAPKQTSPVQARRVGDKCPVFSDRKSRIRMPPPSPLPLNGPRKNTVMVQAEPSPLESPEHALRQIQEQLKKFEEPVTGAYSKDHTERLALLEDLEKEMGIHENHWQEMKHDMGRDSLCSMQTNSPANRNSRYDSTVGSIVIGHGPAVGAMAAERRASRQTMLRNSGSYNPNRLSRDAVKSHMSIWQKRLTEAHIDYMETAAERLRQPSGNFLPIPLPNVQLGSPTPPDSDVSGDDDSVLSAQLDAVSNWLSKKAVKTVSLWAPAPQETTVAANLLWTPVPKASPTSTIATSEVQTFVRPAARKDLSPLRITSMQLWSKPTVNVKKAPSLWTPPVPVQILETNALWAHIPKVASECPTPLPEADAFVRPATRKVLAPLEITSTRLWKKAEHEKKPSLWTPPPKVSAVTTNRLWSPPPKVLEAPSLVLDLPDIFTRPAARKDLAHLQISSKYLWRKPYTSTKETTGLWRPSWASVAPPADFKRLSLQETPQPQPQKAPRPVTQRPPRRNKRVSALPDILENPEPLPDKRGTLGLFQFPWGEKSDTATMPQPRPFGRSMPGTMSSGVPSLRASSTPDYSGTSFFDDYDDEDPESDYEREESDDEDDFDETTLWEIASLLNSTAVPSRNSLFLSATPAYSVDEYYDGGSGSSHQEQSASASATDIDEDDDASSEHSILIGLAEDHPHDDQEHVAEQYDHQGFLQMQDTADSTPSTLDQGAQAVVATRAALADDSAPAPAPPRVETSENQAVETRLQISTGLWSPGESPENKTLSSPRSAETKGLFVLGRESTSDNRTTEQEPAAVNMHRTPQGKAADSWRPLDRLMSDSLWTPEAAAAKGVSRQVFQHWITLSLAANAQVDKAEAARLPRPQATPADLKEALIASGYPLNINKTVSGRITATPADWAAALEEAIQASIIKSAGPVFNSAIRHPVFAGSSLTTTSEWFHPAATGYTYDAACVHPVFFGSLAITCPEESVHPAMSAYAHKKLRRHQRSGSSASRSHSRSASTSSTTSRKNSRSHSSSSGKKRRESIIAQIHAIEAEMGLIPEESAVVPDVPEVPSLDEIEASRKAKIQAQIEALEQEKLFAQQVARESSVARRRGSSSVSHATTASGTTNSENDGPASMDSFPLSQRPSTATSVDLEHDQEEKSIDVPELTISSPSPSTPSQADNGLWTAPSPLPQPTPSPIPTLWTSPPSPASPFESYEDSLPSPKLLWQPKAGKPEIIAKTDEDREAHERRAMGRKGLLTMQRKAEILEQIQALENGDVTAVKGLWTKTEVVKVERDWMATQLSGELSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JCC6</accession>
    <name>A0AAE0JCC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_221813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680310.1">
        <property type="nucleotide sequence ID" value="XM_062822060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JCC6"/>
    <dbReference type="GeneID" id="87859214"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3342517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="434" mass="46901" checksum="E50BA561C3CD65EE" modified="2024-05-29" version="1">MLINGEKWACEACVRGHRVSNCQHHDRPLQHINKKGRPVSQCQHCRSMRKYRASHVKCDCGEKTSKCIHLQVTVEGHKESCCCNHGGRCTCCHKKEHPQLETVPESDSDKSCSSVSRSCSKSASRNRRRANTTNSDAMLSFDANGHHKPTYKHTKPSQKCGPYTLSRGNSMHSTTSSLGARSVDNLDVSGSGIAMQRGAQSESASPLMTGSSTFAQLNGQLPPLDLSGIKYTPYVPNSADFFGSLSDNDQPLFSAGLSATSVDWSHYEGLDLGNKSADFAPSSYGQAQSYGSFDYYGSESLSTLTTNTSTSGDISEVEDFLPALDDWETASGFCATTPGSGFGFGQPQPNLYGAADPFLDFEEFKMMKAGAKFLANNSSLTSEDSSLLTSNLPDFSNFPLEDDPAFWITHYGGLALQDPAPADGTVHPLWDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JD03</accession>
    <name>A0AAE0JD03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_429412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680017.1">
        <property type="nucleotide sequence ID" value="XM_062824822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JD03"/>
    <dbReference type="GeneID" id="87861976"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3342224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32736" checksum="B071DCBCE251DE81" modified="2024-05-29" version="1" fragment="single">ASSPTTIHHHIKQSVILHLEHHQILANGVHSRSLKSNKMDSRSTTPTPFPTLQVQHKQTSTTDHKTTSSPPKPPSPYGSLQWTQYLLRLFTVLTSAALLALTVFIAVKWGQEYMEKIYAVIMAGAVIAIITDLGTIYFLFVRMSQTSTPVAIAVLDAVALVMCAVGIPSVMGSEFKTVYDTAVWALAVVVIVERAASMATCLWVWIFIRRRSNEGMKPVIFKQEMGSTSESALAARRRGKQPAGQGAAMAGADAGAPTGEYLHPESARASSVGGGRPSLVLAGDMSGRASFPSIFVGGEDADDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDI3</accession>
    <name>A0AAE0JDI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_470616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680969.1">
        <property type="nucleotide sequence ID" value="XM_062827051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDI3"/>
    <dbReference type="GeneID" id="87864205"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="6">
        <location>
            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3343176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="400" mass="43516" checksum="7F722A6E0AD64BB7" modified="2024-05-29" version="1">MIVGHRAAAIAFFGIITVILIIQSLRLHGVPTIRHVGSQLSSETSADVLNTTLGFQKIFVINLPERTDRHDAMTLAAALTNLQITWAKGVPGSEVPDKVVLGEDWEKSILRGNKGSWRAHMNVLNTIIDQNLTSALILEDDADWDIRLKSQLHIFARAAQPFTQHNPRTTTPSDDKVTNLPITSIPSPPNQSSSSPYGQNWDVLWLGHCGTNFPTSTTLTTPPTNTSLLRVTIPNDPTVPSPQHLKAHPFALQDQLAELYPPHTRVVHPSSGTICTQAYAVSQQGARKLLWRFGVKEALTKGWDLALGEWCDGAFFGVDGSNGNGKQGKGKGGGAPVCVTVQPPLFSHHFGKGAASDITAPGGGFVNKDKEMTPYVRWSVRLNMGRLVEGGEVRDQWPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDK8</accession>
    <name>A0AAE0JDK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_233512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680698.1">
        <property type="nucleotide sequence ID" value="XM_062822221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDK8"/>
    <dbReference type="GeneID" id="87859375"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3342905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="129" mass="14217" checksum="CEA9494792129F34" modified="2024-05-29" version="1">MTDRLICVGATQQQQPVGTLLLDLSPPEYKTNISIALGGQMHGFTLDLPKMALVCSHWPSQIFISSEWLEPLGLETEHFPDNQPKLFDTPQGPFEACRRVTTTISLPQLQYGPVHVEAIVLEYLGSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JDV1</accession>
    <name>A0AAE0JDV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferredoxin-like iron-sulfur subunit of mitochondrial complex I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_550497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681130.1">
        <property type="nucleotide sequence ID" value="XM_062829741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JDV1"/>
    <dbReference type="GeneID" id="87866895"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3343337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="221" mass="25061" checksum="FEB5EE5891CEC32F" modified="2024-05-29" version="1">MLTTTASSAAAVARQLTTRRVIAPSSFFVAQAIRTYATPAGPPPKGFRIPTPKTWDQEEEHALDKNGRYFLLTEMFRGMYVAMEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLANGDKWEPELAAAIRADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JE43</accession>
    <name>A0AAE0JE43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_523694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681204.1">
        <property type="nucleotide sequence ID" value="XM_062828803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JE43"/>
    <dbReference type="GeneID" id="87865957"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3344591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="267" mass="29409" checksum="52E817F835018A63" modified="2024-05-29" version="1">MFQKLVNKVRLLLGSKRDGDEPGKSPPQQPPPPSYEAATATATIILSSLGRPADALFRKATCDRTNLVLTKEGKSVLFMYYILLEHALLNITGSYQYKKLPQHRAEGTPAASRAMVNAAGNYAFLLALLHASKQYNISEARLSLPVSEAVHAIREDVEGEIVKDLLQGNRYKEERHVMQELVDKVSGNIVTHAHVFDDSGGLWGTGRIRDSVDTGELDVSKVQECWRLFKSVLAETGSRHHNCGDLLPPPGFTRYSGRSQAALRGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JED2</accession>
    <name>A0AAE0JED2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_186164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681420.1">
        <property type="nucleotide sequence ID" value="XM_062821574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JED2"/>
    <dbReference type="GeneID" id="87858728"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3344807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35609" checksum="F31B5C5410D3A6C8" modified="2024-05-29" version="1">MPPRLPGPQGLRSLTLCLRPAVASPAQALQPLIQTANISQKEKKRKMKQDPYGWAQAQQRKAVNVKRQAELQAERDAAWGDPVKGITTPFVESFDSAGQAPVSAPKAGPDGQVVEEPKPLPTSPHLRNYLLNKDEFDSAIQYAEHILKPIKAEDRSTADPEKEDEEAREHAARHAKAVAALERIAKLEHGGAKDRKHANIRRCIETFGRHNTDHTVERPTPPLARGVEPKPQPVRAGPDTGSSEVQIAILTSKIRALTKALEGHGGNRDKNNKRSLRRLCHKRQRLLSYMERKERGSGRWHHMLETLGLTPATWKGQITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JED3</accession>
    <name>A0AAE0JED3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_470928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681103.1">
        <property type="nucleotide sequence ID" value="XM_062827064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JED3"/>
    <dbReference type="GeneID" id="87864218"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03995">
        <property type="entry name" value="Inhibitor_I36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042002365" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3343310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="111" mass="12212" checksum="415B25C82AE805F9" modified="2024-05-29" version="1">MKFTTILLALGTTAPAVLAADMDLVDMWVDTNFNGPKYTGRGDVGQCVNLPSNFNDNLSSGKARPGYKCTIWPDADCKTNRFDSSFDDKGSGASFPDWINDRASSWRCYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEJ6</accession>
    <name>A0AAE0JEJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_426270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681208.1">
        <property type="nucleotide sequence ID" value="XM_062824623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEJ6"/>
    <dbReference type="GeneID" id="87861777"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3344595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="646" mass="70476" checksum="3461653CCB4FA215" modified="2024-05-29" version="1">MAPAVGIDLGTTYSCVGVFREDRCEIIANDQGNRTTPSFVAFTDTERLVGDAAKNQVAMNPANTVFDAKRLIGRKFSDPEVQADMKHFPFKVIDRGGKPVIQVEFKGETKVFTPEEISAMILQKMKETAEAYLGGQVNNAVVTVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDKKVEGERNVLIFDLGGGTFDVSLLTIEEGIFEVKSTAGDTHLGGEDFDNRLVNHFVQEFKRKHKKDLSTNARALRRLRTACERAKRTLSSSAQTSIEIDSLFEGIDFYTSITRARFEELCQDLFRSTIQPVDRVLTDAKIDKSQVHEIVLVGGSTRIPRIQKLISDYFGGKEPNKSINPDEAVAYGAAVQAAILSGDTSSKSTSEILLLDVAPLSLGIETAGGMMTKLIPRNTTIPTKKSEVFSTFSDNQPGVLIQVYEGERQRTKDNNLLGKFELTGIPPAPRGVPQIEVTFDVDANGIMNVSALEKGTGKTNQITITNDKGRLSKEEIERMLAEAEKFKEEDEAEAKRVAAKNGLESYAYSLRNTLSDSKVDEKLDAADKEKLKSEIDKIVAWLDENQQATREEYEDHQKELEAVANPIMMKFYGAGGAPGGMPGAAPGGFPGGAPGSNDNEGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEU6</accession>
    <name>A0AAE0JEU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_539293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681473.1">
        <property type="nucleotide sequence ID" value="XM_062829114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEU6"/>
    <dbReference type="GeneID" id="87866268"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029764">
        <property type="entry name" value="RSM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3344860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="240" mass="27814" checksum="B9BEDC3334E52C8D" modified="2024-05-29" version="1">MGKGRIFQAAKVYQRASEAAATNIVSGLPPRNPPLWLKAIESIPPAEISTRPYPIQHSPPNPRARKPRNLFKPTKIVYPEDELRRDFYRDHPWELARPRMIIELDGKDARFLDWSKGLRQRGMPLSGESVVQRQLWLMERQGMTKQEAYDKARHEFYKLRQLEQMERRIAAEEARMVGGYFGKDLLAVGMELENRTYESWKKWATTEIARQESARASMYTNVVDNSALEGAEEDELLAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEW4</accession>
    <name>A0AAE0JEW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_194893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681705.1">
        <property type="nucleotide sequence ID" value="XM_062821700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JEW4"/>
    <dbReference type="GeneID" id="87858854"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3345092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="209" mass="22913" checksum="B4F13F4B7E708362" modified="2024-05-29" version="1">MSDMSQDESVRRACVDTSTGNAVLHSRVSSGGLAPTGSGSINPANQRLDCFHFAIDNHPRGPHVYAGPMWMGLGDPTSTTHFNTCPPWFGYLKLPFHPSSLFFPFPPWILLTRTTGNCSVEQVCLNHPTVCPTRGSITKATAQVLDHLRLGHLFERRSVQITLYSIPHRPLTSLHQCISEASPSTPTSRLSGFHPDLELPSDLASAFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JEX7</accession>
    <name>A0AAE0JEX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_442372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3344905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681518.1">
        <property type="nucleotide sequence ID" value="XM_062825574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87862728"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000817">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="8">
        <location>
            <begin position="635"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1501"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="496"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1180"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1195"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1502"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1525"/>
            <end position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3344905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1758" mass="191515" checksum="78D3DFC625C1693D" modified="2024-05-29" version="1">MPRRQEAQWKHCLIHWVPPSPEGWLESGLACASQAGLTTVGVNCGRREPTGGRQNQKRPFLMMPNNFNMPGGNVSGDGESDRAAASQLLLAQLRRQQSSTSPNPAAGPNGSNQYGHLAYHGHHGHAHVHDRPQAGQSYYGPDSPALTGSFQNALDPAAFLPEAPTPPIHAFNNSQFPPGLMQPIGAARGLPPAGENRTAQLLNLLKFNGQGSSSNQGQPQFSQEAQPSYNVPPPTLHAPAPSGSDPSGLLAALMRGAHPEQPKQEEAPASSSSWNQPAPPSNTQQYLLNLLSKPKPSQNDTSEIVESSLLIPPPAEDDSKDAGKSADMTLLGTVPSRSEFDFEPQGLESTPPKFSSTPQSQHSQPASAARSGIFGFSGQHDDHSVSSPSQRTPKSSAGSAMDPNASRPPAAPAIQILRKPDPHDPKRPLSDHSSTGSPDHTRRKLEHVSSPHGSAGAPRVAPNIITVSPGSEAKVELGQDHVEGEKKKESVAEAVVGLAEQADREAQEALARAEEESAQAEIAQDLEQMMSAETDEEFARSAQIAAQAIQKQLEKNENKDVLESALDAEVAKEVRDIVDEAAQAAQGAVADSWESAEADEIVVTEETAAPIKVYNFPLKPWITISVQETDEVRPVFREEAILDIARLKKEFDQIDRNLVSASESYMAYGMSKAGGLRVIRQEDGKDAKLFTDTKDRIFNVAISSSASNQHPKEAIIGTGVSGTVYWVQLKNGDRDHLEDAHPEQYGFALPPLSTQEGGDAPGGVLKTRARPSSMHPDYFAVGRGKSINIIWPSFIFENNLFKNAHDRVVDTERLFKQCSLKINTGKAGKDFTFSQDDTLMVTLDKSGRVKFWDVRDLTAVKEGSDPLNPMPAHTSLEIKDPLMTLTTTPEGEKAWPTSVLLLDKYRPYQKRAALRYMIVGMKQNHTLQLWDLALGKAVQEFNFPHNKESDAVCSVMYHARSSMIVVGHPTRNSIYFLHLSAPKYGLKNLSQVDYIQRLVAQDPSIPQPEATAVISGIREYSFANKGVLRSLGILGNPAGSTDGDEANLFELYAMHSKGVTCVFIKNGELGWSKDNKVICPADAEKVGLVKISKLVAPVQPVEVQQAPAPAETSAPPQIRIATRPNKEILQKTPSSQGDDKKGVDSVSTVKPDRKEDTETPVQNNNQPERAEKKGRKKKAAAAAAAAAAAAGDSAVNGQAEQQATPTIGRTSSQVKARSARNADSSALNLPSQFSDLSLNGSGISQEQLNTVIADMESRISNNMNNMPGRMSSVFESSCNDMFKRQREQLHGWLQDWVRNFMDNRDDLFLKNQSAVLKVVADVLNDNTETVLKHLIVDQVNNAVVPAIRSTVEKVAKDQADSSLNKQLPAMQKEIEKRLPSLLTQSLQKADIAPSLVDKLADQVLQKVATRLDVNVANQFAKSFSEQLPVLSKRVAEDVHQRIAGDISTRMGETIARFEERKRDDDAKLDRLIAQNTELSTALAALAASQVHMQKEFSTLKQQLHEQNRDREFVGQEPTHSHTHSRASGSVSSHQQAGGPSRDLVAYAPPQAHQQQHTQSIHGMAQHQQQQFVNQEQQGLFSPTPRENREKMELNNTLETIDRFMSAGQYDQAVMRWLQAEDKSEEVFQQVISKYDPRCLSGLAPIFLLSVGASIVSNLSRRSPKVQAKIALVETVVYAMAQALPHLSVLLQEDQVVEAVPKVMSLIQAKVEELLLAISRESPHDASLKTLSSIAHLAGRISESCQPSRQSLGHPGAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JFI1</accession>
    <name>A0AAE0JFI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H65DRAFT_465337</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681656.1">
        <property type="nucleotide sequence ID" value="XM_062826800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JFI1"/>
    <dbReference type="GeneID" id="87863954"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000168">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg11), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="17">
        <location>
            <begin position="100"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="17">
        <location>
            <begin position="176"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="16">
        <location>
            <begin position="374"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3345043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="579" mass="65091" checksum="1331C19BF0450668" modified="2024-05-29" version="1">MANGLLTYVAIPLFTIGPLLVLFIPFIWRLVGSSLGWYLRRKTDGRRCHILEVVEADERKYRDSKGAKGRKEEKDETEATGTSEQGSKSGKVYDKDWDGIVGFFHPFCNAGGGGERVLWAAIRATQKRWPKAKCVVYTGDHDVSKEAILSRVEVRKRPTVPSSMVFSSVLQPLHPQQHRFNIHLHPPTVNFLYLSTRRWVLASTWPYFTLAGQSFGSLIMAWDAFSLLVPDIFVDTMGYAFALGFSRFLFRDVPTAAYVHYPTISTDMLESLDPASAVGSQGVNAGRGIGAKGRAKKIYWQLFARLYSLMGASVDVVMTNSTWTQAHIEKLWGPVRNLTGAVPGITSKVNPIAVVYPPVAVEELEQEVEVSPESEKRRENVLLYIAQFRPEKNHQLIVQAFAEFLKSGSEAARDAKLVLVGSVRDDYDSKRVYKLRLLVNELHIKDRVEFHLDASWPDILEWLRRASVGVNGMWNEHFGIGVVEYQAAGLISVVHDSGGPKLDIVVEVDGEPTGFHAMTSEEFADGFEKALSLPNPYAVRLRARKSAKRFTEEEFARRWIEQLEKCVAMKAVEKPKSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JG60</accession>
    <name>A0AAE0JG60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Shugoshin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_493764</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681712.1">
        <property type="nucleotide sequence ID" value="XM_062827770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JG60"/>
    <dbReference type="GeneID" id="87864924"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="11">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Shugoshin C-terminal" evidence="10">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="678"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3345099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="84311" checksum="563909CA2B42330A" modified="2024-05-29" version="1">MARLNEQAMSSVSSSTDNLELLRRKFLRQNRDIARVNSTQSLRIRGLENECARLLSENLELHGQVLRLEKELQGNAAQRVADHALEVKAKMETQLAELSSLLASLGEPPSKRRPSEERRYAQPRPSVHRSPPLRRARQEADQELLAEQEGRLPPIYENKTYARATMNSEEILALCMQADDSNDSPDIGPPPVSRFVEDDMVIHRSPSPNKNSEIEETEATEQVEESPRGLQVPPSLSPPKLNYDRRPNMILFSPPKESRIAEPTKMSSPLQMEPPKQSASAVPSETVRAGLKRKFGDENENEPNKATKLQPEKDNGNTTGKKKGLSARDPQKRKSIKETATKPRAPLSAKSTNEHIASPKKATKAHEVDDGFKPVKVHKAQMGKEKADLPLPEENPAVEEAQGTSTSAFTKIEILPPALEPTPEVAEIPEADILITPGTPERASGSTVVTHDTPPPAHISSNGETSRPSRRARAAISYTEPNLRDKMRRPTKELFDAVSGEGKFLHRPAAQQQQQRKGDESAPASVSKVKAEPSPVVDMSGLSSSTLFEKEKEKEPHQEEGILSPTGILPSSVDLGRRRRASSFSTAAGTMTIPPVREQPTPNPPAAEEMDEDAAVEAQIQKELSNSVTTRPRGGKGRQSMSRSAPTILTEKQEDVQLAINPASVDLYDFASCVSPDTAAPQEEATTGDVLGNKKAPKGSRRASSAASTDTTATASAKPRSSRKRASMLVPKKSLWAEEQPQEEEEEEDVGNDSGGSLSKGRASRRRSMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGC2</accession>
    <name>A0AAE0JGC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactose mutarotase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_206512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682061.1">
        <property type="nucleotide sequence ID" value="XM_062821871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JGC2"/>
    <dbReference type="GeneID" id="87859025"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042051500" evidence="4">
        <location>
            <begin position="23"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3345448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="410" mass="45351" checksum="94F4668CFF442194" modified="2024-05-29" version="1">MRLHALFLQGALSLAAAATTSSSKIPSPDANGKYWLNTTRLSLAFIPYGASITNLILADKHGKPLDIVAGYDNATAYTLDTAHPHFGSVPGRYANRIRNSSFTLFADDDSEEETITYHVTPNENPTPSHPQGVDTLHGGPDGWDYRNFSVVAYTNSSITFSIVDPDGKEGFPGEVISYITYTVSGSTWDIKMVAIATTKKTPIMLSSHTYWNLDGFELEDALGHELWMPFAGMRVAVDGILIPTGDLQNNERGGVNDFWSRPKQIGESFEKREKGLEGNCGTNCTGYDNCYLNTLRSSPSSSSSDWRQPSQMIARLSSPHSGIKLEVYSDQDAFQMYSCNQQKGDVPLKWTQGTDERRTIPKYGCMVLEVQDWIDGINHPEWGRTKKQVFAPGGDPYVLQARYVFGVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JGR1</accession>
    <name>A0AAE0JGR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_521720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062828759.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87865913"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="OpdG"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3347578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="347" mass="40558" checksum="9907F432E514679A" modified="2024-05-29" version="1">MSTTLSIPQAALDMGIELDFISDPEDWSDFGLMDLNEESSTPEEAAALREFVQAYNTPNALDAEETARKLMSLNEDHVPCDGDWDKGERIAYLLWDVGIEMAQHQVAILVLVDAAMALPRLDATPEQEVRFGAEKLERWRTMEDFWDVWETRWIRYYEWRYHRRSPDTEYPAYPRANAFVAHHLMLHPPDFYYTSELSTAFARMTMTLEKGYGLDDGIALGSCEAQAAVLKIATDIHGMIPFLVIAGDIMYRYTDRDLISRRFAEAHQENHQHNTSEYWLWLWSSSSERSLWKEEKGDGHEWLTRERWAFWKKRLLWMSEQTELKQRTRDEAIMLVQVMTEIEGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0JIR5_9PEZI</name>
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            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062821428.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87858582"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
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        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3348416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="40891" checksum="1F9B25B696CC40B5" modified="2024-05-29" version="1">MASPAENTSGTDAAITMASPALHAASPTPAAPTPITNKPLPPRPTTTTTTTATTIPNDINTKPGASVYSKPLMLTTYDKYVLGFSMTYLWRCPSSTILVPFFRENFRAEKHLDIGVGTGFFVGDALAERLAKDEYFMPLERDPDSKLVQPKIEITLMDLNGMALEKAKERVLGVVNNARVGGNGKSGNGTSGNGKSAGNGTNVAVNVTTIQADVLDESLTLPEGKLFGPGSALGTSRQFKSVSMFNLLHCLPAAPEPQGQEIKNRAFKLAAECLADDGVLSGCTILGRKYISSSSRPGSSRPGSSGTGSGSGVKKGVGRTGRPSVLSRSMTWTVMKWYNAMGVFGNWTDEREGFEKGLRENFEVVETHVVGCMLIFCAARPKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JIT6</accession>
    <name>A0AAE0JIT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitination network signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_555542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683755.1">
        <property type="nucleotide sequence ID" value="XM_062830033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JIT6"/>
    <dbReference type="GeneID" id="87867187"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="681"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="794"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="957"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="980"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3350460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1172" mass="125242" checksum="663FDE8A2939B857" modified="2024-05-29" version="1">MVPRGFLGHKTSPPPASTVHQPLCACRRHAIHPASSAHARKFKKSQPTTWFPKDRLPDAQIRPKHIAIPPITDCGPPLCHSHPISSSICLPGLGDRSPTAGHASPPREAQARARERTPSVPTLTTTTSTFPVPVRRMPRASNSAKRQQGANNQRDTRHEGGLVGPGKRIPKQQKSHQQLAALDQRPTAAVVDNAAPAAVPQANNNNNITTAANAFPALPDDNNNTMAAESQRRGSLGGAYSESESAESLAFPPLQSAHEENHRQINVNDAKNTNVHRDPGPVEYALTVLKSCPIYDTIAILIILMQLSPAFLAIVYMLFTLLTFVPPVTTSSGLTIADIFDGNQGTPSLTTLVCMDVAVLGIWLFLWAPMQQFILDLAQVVISLTLGGGGSSRTSTSNSIFLCVAIIGASQWTRQARWNGLSHLSTLFGTNRFFPTSHGGPIEHTVRAFEKKGPYGWGLVRYIREWERRDLQSQSQLDPEAGKTVSFSDSCSDAALMAADSDAHLQTSAGTKRRKQSAQPLWAALASTKIVMYELSHAASESAGSNATDIHNLGNAPFNTQPEQIWICYIGSDEFCFNTNFPDDETAGTPGPFYVRVNNAKWQPTRIIPIEGTEEDKHQGTRDIYGLTPLSNYACEFVSTRTDQANAKSRDPEAPAKAAPNNQRVNNVRHDSPVTTLRASIAAAEIKLADEKARLKAARKENNRRVNAAKKEVEKLTAAVQSAGGDDDKLKQKVAQNKIQEKRAEESIAQLEAELKELEAIPEELLAEYRSKQSTWKCEKARYEEARSAFKSFNATLESELKVLKDEQTSLQAKQKKVESRINKVKEEHKRITDANAQGLGEAERRRQNRATLEADIATAERHLTDRINSVRSMNMAKQAQISDMSNQIHAYLSSVQEDMAYGHAAAVAGGQYPQASNASTGWGMPPVGATAAAAAVNSTFANAPAQTLWPAATAAASGSSSLGPQTGPAALLPPPPIGGPFSNPLQQQQQSQQAAIGTPAQQRKARDRSSSMLSDISGFTESTDEDERERLERERLAISYGQNHQHQHSNANTIFGTPGSMRGAPPGFGFPTRQQRLAGNNGTFGPIGGGSSSGFNGFTSGTALGSGSGSGSGTGSAVVSVGSVGSGFASGGSASGSGVDSGRSSVRSAGDSAGSGSAEGSSKDPGSPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JJC7</accession>
    <name>A0AAE0JJC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_455719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684024.1">
        <property type="nucleotide sequence ID" value="XM_062826250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JJC7"/>
    <dbReference type="GeneID" id="87863404"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="196" mass="20607" checksum="5FABDB14DEA59977" modified="2024-05-29" version="1">MTTPSPSGAPKPPPPAMIPVIPLPDTLCVPPPPSTTAQSAKRARTADEEVRPAHATTAIPAASGPIKSFAGPSSLKPSPKRRSTAPSPPSSTPNSPVSPPSRPLTHVKLTASHGPSPPPCRKVLLHLPRLLRILLPQQAKRSPLPLPERERGPFPSPKLPPAVRIPPPPPALLPRPTPASPIRLPYPKVTAVSFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKR2</accession>
    <name>A0AAE0JKR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phthalate 4, 5-dioxygenase oxygenase reductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_555745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684052.1">
        <property type="nucleotide sequence ID" value="XM_062830036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKR2"/>
    <dbReference type="GeneID" id="87867190"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="Tri_helical_YiiM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="YiiM_3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="4">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="250"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="488"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3350757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="573" mass="63180" checksum="921CC75CEE58F138" modified="2024-05-29" version="1">MAESQSKINLYAPFERDTILEVRASKMKKMRGLDVMSGIDKTIIDGPVYVGRTGLEGDESDPTFHGGIDKAVHGYCSSHYPSWASEHPSAAVAFVPGGFGENLVTAHMNERNVCIGDTMIVGSPSALTSNPDSCLLLQVSLPRQPCFKLNHRFQLKKFAPLTWKHSRTGWYYRVLRPGFVQAGDEIRLVSRPHPEWTIERIQEYLHRNQDDEAMNAELAQIEELGAESRDAFKARVARSAAQKKRAEKLARWRDFRVVERHTETPRIVSFVLEAIDPIVPPPGDEKSILLKPGAHARVKLGNDLVRAYSIVGPPDDASINRFQLGIALEPQSRGGSAFLHSQVFKGHVLQVSANFTNAVPNAPGISHHIFVAGGVGITAFLTSLEYLQSIHVSCELHYAVRSSSSDDIPFRDRLSQLNPGTVKIYDKTKGQRLNIEDIVKNIPWNTMLYFCGPSSLVLDAATQVRKYNVPEGEVHFEAFEADISGDPFEVVVANRNDKTLQVQGEETLLEVLQKEFGDEEVGGSCCVGNCGTCKVNLKGGRVEHRGTALTAEEKGSAMLACVSRGVGRIVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JKW5</accession>
    <name>A0AAE0JKW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_124129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684820.1">
        <property type="nucleotide sequence ID" value="XM_062820717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JKW5"/>
    <dbReference type="GeneID" id="87857871"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1041" mass="119140" checksum="58ACD197E509995C" modified="2024-05-29" version="1">MSNLQVPGEQGEGKVRAVSNPLPGLASLNFNNYGSDAQQDYEAAQASRANATIDEIEQRGIVPDVNLVERELLRPKSRIKRAGSTAHKIFSNRAASSRDPSGSSDVNTLNLGLRVYPSNEEQDAVVNTLWEEFANDGGLSGLSHQQVSLLYQHWHQRALAINESAKEWQALNEPSPKATEPRVSTFDLFGSLMTDFELLLEVCKHLRPIDIINLYSVSKSFHDLVNANLQSTILLWTDHMAPSSARIFCHQLYYQYFIDDPSGRDPSTHRDIRYFNREAPNYTVYQNQAGEGQFGPVNPLPPADPQHNIRKVPSLIWFQMVVDREIKVRDILATLARHGHRTPPDTHKTLKKLWLLMDVASCRGRAVLIRSQTLFTDEDLYRARLFFIKLYMLFADPVFGPKSTALAKLFLGQKGFTPLWQFLRRKKYTTEQEIVEMKTRYDVRPTLLQVLDGHPINGVPPNEMGMMHVEGWGRGVRHLLRPDQMVNWEAYKRGLPLHLRAERMMLYGHVDFNTGRPLVPSLDELYMSDDEFDLPADSSWRIMKHHKAHGGCGNVPFERGMWQPKHARKARWKTLTEEEKEDILAAEEEEIKEEKKLRYVEGDLDVALADLEEALYDYAVEKEEGSHEEHGIDGLEFDSRVPMPDDTSHADEEEEFDDTDWENCAKYMKDLDRVPDQLTLIRQDKAYSQLNRSLIMAKQVFDSKAKSNSERQEQDKAWAHAIVHQLPLYTGANPAYRRGVPVAPRNNSPASNQAFFNAHNGNHDWVQPVYPAQAELPDVRAEYLLKGAVALHNARLDTGDLDPATDAMPDDEVAELEDEEITKQIEKNVNYGWMLHMPRKQPNNEAGSSSQDQDDHSGNEGASGVSESMDMDMMDMDDMEEDIDDDFNDLITSDFDDFITTPNFGLHNPNNASPSNTIPLSPTPSASTIDQPSPNPYIPIHKNQPTPNTNPNPHNPDLPYRTQMYHYHHDPDEDFDWRGWLDMQHQNDLLSEAARLDRNLLNGAHEIGPEELRRRVESTIERTRGYKSLRERFLRRYYRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL25</accession>
    <name>A0AAE0JL25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_128801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684939.1">
        <property type="nucleotide sequence ID" value="XM_062820778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL25"/>
    <dbReference type="GeneID" id="87857932"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="157" mass="17350" checksum="FB51A1D22A5AFEC8" modified="2024-05-29" version="1">MASSTTDSRRMPRRDSSTARGTRSPSQRPRLLRASATEPSITTSNASRDALANSYSSRRATELLRVAYISGGSSPDALTRATSRATSPISTRPPPMYDSLGRHSELSSSPISNPDGFDELRDSYSHSHSERYISFPSFDLYESPHQEEDKEPHMKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL51</accession>
    <name>A0AAE0JL51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_420050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684929.1">
        <property type="nucleotide sequence ID" value="XM_062824252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL51"/>
    <dbReference type="GeneID" id="87861406"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3351634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="108" mass="11702" checksum="C48D97C15EBA9BC5" modified="2024-05-29" version="1">MDGNSSTPRITCAYLSQYVGKLVTVVGKVVQLRGEEATIDADGTIHAFLNREAHLSANNGVQIIGKVNPDLSIKVLSSVDLGQGVDYNLANAVVEVTHRYKPLFLYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JL60</accession>
    <name>A0AAE0JL60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_115989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684668.1">
        <property type="nucleotide sequence ID" value="XM_062820651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JL60"/>
    <dbReference type="GeneID" id="87857805"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3351373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="393" mass="41729" checksum="F501D34AD349BFB1" modified="2024-05-29" version="1">MCTSVHTPWCLPLCTNAGAFPASLRLAQVLGDVCTSACISRCPPHGDGMVVTSLLGCEFGSPVQFDSVHFISVFHPEEHLPMSQDWLNFNVGNSTMTRRSVYLTALAAFIAVTTMTLTSILLPRWITYSSVTSSHSPHKHHDSHSPVHVHVSASGSEVFHDYIGLHQRCQTPVTVLAYGKHGKHNGQLKLECFPFPDSRFCSGFHSGPSLGPPPSPSPGPPPPPSDPIPGPNPDPPKPGPDISTGQEKRRFFCTTWKSTAFLMNLSLVLEAATLVGFVVVLVLAGGGQGSGQGGGRGGRGGRRRGNAREMRQERDERKEKEGWKVLAWMIGAVGVGEGLAGGLVVSYSVSFFLSSLFANGYDDGGGSGKGGDEDEDEDDDDGMWATGCGGCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLL6</accession>
    <name>A0AAE0JLL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_418508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="9">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684781.1">
        <property type="nucleotide sequence ID" value="XM_062824148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLL6"/>
    <dbReference type="GeneID" id="87861302"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3351486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="78" mass="8832" checksum="B5A481916BEEE94D" modified="2024-05-29" version="1">MFIILTPVSDGVGVLIQCEPAIKSIIVHLDSVNNDIIIEDLDEQTLVVKENMVQLLKQKLEDRLKETYRPEEPLADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JLM4</accession>
    <name>A0AAE0JLM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_139819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685224.1">
        <property type="nucleotide sequence ID" value="XM_062820919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JLM4"/>
    <dbReference type="GeneID" id="87858073"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="277" mass="33018" checksum="1A082BA0CE12E38D" modified="2024-05-29" version="1">MTTFHPFPQLPWELRAQIWEMAVEPRNVSVVLPLGYNDFEPYEDHPKFELWGPRIWTYTPAPAALHTCQEARNHLQRQRIYEQAFRITPTVRLKRFPNTLKFRVWRYGKKSRRGVVDELDANAEAERARRYVWVNFDMDIINIGVIKFSAFKNFDGAKIQRLQTKIRSRRFEYPESTYLVDTFPNLRELYIECSVGDVENWDEHYEKLDELVGAENVWLYPHWLGPGIFSSVITLAKMREELHEFWRREEEEERERSGDGYPMGCDGRCGMHLPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMB2</accession>
    <name>A0AAE0JMB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_504367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685614.1">
        <property type="nucleotide sequence ID" value="XM_062827908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMB2"/>
    <dbReference type="GeneID" id="87865062"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="507" mass="55675" checksum="EF0108C7E95A0A13" modified="2024-05-29" version="1">MGVHIHQHPTRESDLGHSSTTSEKDEAAVQGNNENVVHKEEFYAGNSIYAKLHQITGRWGVEERGIERLPSDERDARKPITVGITWFSINMTFVSLTLGVLPVTAYGLSFVDAAILIIAFNFLGSLPVALFSSLGPVFGLRQIPLSRFYFGYHGAKLAALINVAVCVSSSAINAVVGAQLFHGINPRMPGWAGILIVSLTTLVICTMGHRFVHTYERYSWLPCFVVLLIVLGVFAHSGNFDPLLPLGTGTAKASGVLSFAASVYTFTAGWAAYAADYSIYQPADPKPSARVFWWTFAGNFFPTVFTELLGAAVMTATVHHTDFAAAYDEAGLGGVFSHVLIPAVGKGFGTFCVVLLALSIIGTNIATVYSVSMSVQVLGRRTQRVPRFLWTLVSTVGYTAFAIPAYQEFATYLENLLLAMSYWISIYLGITLTEHFLFRRGVRGYQPEAYTDAKRVAVGIAQEWYRGPVIKAVGEEFVGDLGCVFGFLFTTVSYMVLRYWEKRYFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMI7</accession>
    <name>A0AAE0JMI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_448084</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685734.1">
        <property type="nucleotide sequence ID" value="XM_062825890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMI7"/>
    <dbReference type="GeneID" id="87863044"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3354356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="213" mass="21427" checksum="7C6348D6FC6F3AF7" modified="2024-05-29" version="1">MASTNKQGKMAGYINYRMRVTLNDGRQMTGQMLAFDKHMNLVLADAEEFRRIKRRQNKPAAPGSSAPAAQTVEQEEKRTLGLTIIRGAHIISLSVESPPPADPSARLGKSTGGGLASTLQAGPGVARPAGRGAAAPISLAGPAAGVGGAAPPPPFPGFPGAAPPGFPGRGGPPPPGFPVFPPAAGFPGAPGFPPSFPPPGAGGPAGFNPPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JMS0</accession>
    <name>A0AAE0JMS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_447383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685556.1">
        <property type="nucleotide sequence ID" value="XM_062825866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JMS0"/>
    <dbReference type="GeneID" id="87863020"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="152" mass="17348" checksum="1F5EB961659685FD" modified="2024-05-29" version="1">MVSTCLIAYRKVPFVRISTPRQLPCCIFWYFFPVISCAFSPCDCRFYIESMLGLSLPSGSLADFIASPNWPVCILSHFCLFDRHVISEFLRAGPPENVDEFGDPQRSTDFRRPTQLRCLCPGPLKPSRRPIARARGNVYAMPIGPRRQAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN74</accession>
    <name>A0AAE0JN74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_415586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685990.1">
        <property type="nucleotide sequence ID" value="XM_062823994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN74"/>
    <dbReference type="GeneID" id="87861148"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3354612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="245" mass="28134" checksum="6E3A8223950DC6F8" modified="2024-05-29" version="1">MWDLWFDIVEESELMEDDDEPVFFGPPRPPAWFHWVAGHGEPPVFPAGLLPIGSEFQVDDLLWDGAFLILPQGPVPEPRDVDDSSGPFWAPPSVTPRQHHFLPREHRTRDEDELSLQMLEEGTAENRVIDPLDNLLLDRPPWAPDFPPPPRATIRDVVNLVESEPPLPPPGWQTALTLLRPWFHEAPWRLEPVTHIPEHIIGQDELGLWVDDAVEVLIRRNRTLLQFINFDIRQEMTAALDVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JN81</accession>
    <name>A0AAE0JN81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_6290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685636.1">
        <property type="nucleotide sequence ID" value="XM_062831181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JN81"/>
    <dbReference type="GeneID" id="87868335"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="72"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3354258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="464" mass="50457" checksum="C5AB4266388762BD" modified="2024-05-29" version="1">MTLRVMPPPKTFTVHSSLLFDPKQKAFRKNISIEIDRDTGSIANVYERDDDDDLRLQIQAGDIDLRGGGKCVLPGVVDSHTHVFLHSYVDRPSIEQMRDASPVERILRATSHVRAALLAGFTTYRDLGTEALGPADAQLRDCINRGLIPGPRLFVATDALASNGSYEIRRENKSLSGSGSGGLLVPRASDPCDGVDGVRAGVRRRVGDGADIIKFYADYRRKVMRFPGPGVSNTSNQPILFPPDDPRKRNPAVPLFGQDEMDAIVREAKLAQLPVAAHAGETKAALMAARAGVTTVEHMFEDTNGLLDEVLKEMKRQGTIWVPTLATVESAAPQFMEACLAAVKKAVDAGVRVVTGGDTGVIDHGLNAREIELFVKAGIPLEEVLEMATVGGWEACGGELTGYRFGWWEKGCRADIIALDADPREDGKALRKVGFVMKDGKVWKRDGRAVDMITVPEFPPSMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JNG7</accession>
    <name>A0AAE0JNG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 90 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_514751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686110.1">
        <property type="nucleotide sequence ID" value="XM_062828648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JNG7"/>
    <dbReference type="GeneID" id="87865802"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="108218" checksum="14FD67C271043E55" modified="2024-05-29" version="1">MASGATGGSQLSAFCAVASFLWLGHSIESHQLIEQPRVSSILVLLTAGAFSYAASHFWQWLPGSNGRFDDEGGSLRPAPASLPKRPRRYFLPVLIAAIIFRLELFHRVTAGLQCSSPGVEAFLPLVILFYELLPGRRARVGSTKEPEEENDPGRTTWDDVADWVAESKQSLTISTFFISLGAYLASSQDMRSTYICTSFDNSTLVRSLQWLGLFLDGVIVILLWRVLAWARTNKSRLISLSVVFLASAVGSGFLYTSLRMFLPSVPLSHHFKGIDALYVFDVVTDGFAVAVLFVSASLLTTEKTPLSLVGIFTFISGLVVGWGKLKLTGGAENTMHGVAYLAIVLICLGTSIFVYANNIQRVVLIHRTILVALMFISLIAATIVAFSNNRNDYLFEHPIETMIFKARTNYDRYLTHAAASKFLPVAVNEYKARYGGRDPPPGFDEWYKYAVDHKSPIIDDFDQVVHDIRPFWGISPSKIREDIRRVAKEPGIALLKVANGTASHSLSRDSEHAMVMDELVKMANKFAQHLPDMDLPINLDDRPRVLTPWEDVRRFTEKAKKKGFGKFLTKREEEEEPTSQPLDLLQPSSSISVRKFQEMTALTCPPGTATRAGIHWDVRDFCLSCVRPHSKGTGIFLSDFAVSQSICHQSDLFHLHSFFFTSPAVPPLRDLVPVFSRSKTSSYSDILIPIPTLDEVLNKANTQPDTSDFDLKTPALYWRGAQAPQVTDELLHGGHQERLVHLVSDNSSSSETLMLIPQNEVRSRAAYERVPTSLLNFLLPFDIGFSSVSSSSSEDSPNEFTTRGSTLPPSPNPLQNQYLLSLDPSPGSSSSSGSIPFTTALKSTAVPLSSTLFVSWYTTRLQPYLHFIPLDIRFHSLHATLAYFTGLKGKASAADRLGNTKGAMINGREVRLKSRTEEAKWIAEQGAKWAGSALRREDEEVYLFRVLVEWGRVVREDRDEAKYVAGAKEAKEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JP00</accession>
    <name>A0AAE0JP00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_450436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686395.1">
        <property type="nucleotide sequence ID" value="XM_062826003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JP00"/>
    <dbReference type="GeneID" id="87863157"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="12"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="973" mass="110604" checksum="A34F85F5F0D6B0ED" modified="2024-05-29" version="1">MMLPSNLYSTYRQYKHDTDIVASWLAQTGKTLGCATELLASNSASPTNVNLKSARLKGKARKSAKAQAHRQADNFSNQSQTRQKYVLALKNFVPLAEFIGTKLNEAKIVEIPAVVPTAIERAITVRKGFAQLLQEHGRALKLESNENHSYFVSVLEKVRHVLEPLFKDCWTKRALPKLPETTATANPFDLLDFYDAPDFDLGGDSTGSSEQAAKGKETVDEGVVVEYEAEDAASSLVAFATLFRDVRALRMQVRSLWAAYAKGELSLPSVAVATNTAINIARYMEEDAGDSIRLNGDKKTAKDWALFYYQMAASSQGIDITKPTPGCNMNLDAFPMFDESMTLSFILLEAWINQARASSEVVTYNGKFGWYEPTIDYDAAPPDVKWQQDKAAFLEVAPQFDLMGRFNTTPPDALPEGLYSGMPVEDELLRGLRLLLTNKDKVLPFWLGFATAIHLDIRRVLGRQSEKPFWAMMRYNMAIDDSITQNLEYYENLTIKGWDQVDGDKRLIRLQNEARWFTENPLYKVIESTGLLTSRNNKEHTFLKMHPLFCGLWIHYIRTTYHLLAAQFERCWGGILYTGHLYNALNNENLINGAAKWDDMDLLHRLQGGKDKFFVGAAPTERDNYHKQLCMMMGFSATSFIASTRNKTRKLVPTKAGPRSLVAQGKVSSMFHNQYRPSMEGIKLSVDDVQAILNKKSPNPQKTPQATPSQLIHQLALDIEAEIPETSVDYLAMHRQCWDFLRSLKTAVDPYFSRVAGPGWIEREHQLPFVVGYIFSTALDPLGGESKMTEFLVLASEVYKEVVAPYRKDVTFFLETIQDYDKMLSHPEDKFLGPMLNELSIEEPEEEEWVDSEFEEMMEYDREMDALCREYDSEWDDEPEDRAAADFRPNDPLLDPRLREGFGPGESFRDPYVEPGEPVTMSVEAMQRWVRASRALERNPNAVSQKDAEWLRLVLRSAEFQNTRQRADRERHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPA0</accession>
    <name>A0AAE0JPA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H65DRAFT_451373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686637.1">
        <property type="nucleotide sequence ID" value="XM_062826048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPA0"/>
    <dbReference type="GeneID" id="87863202"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="867"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3355259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="955" mass="102869" checksum="88EB250CA38C530B" modified="2024-05-29" version="1">MEQQQQKEKAPLRSRVANACEACRFAKVKCQGSSQVGICKRCLASKRECIFKTGPRKRRPRGLRVTADQNSTTTTTNTNPKTSTSTTATTTTTTTNPYSVQSPLPGPPPGPSRTFTIDVPIPTASVDVAISLESLRLDHEGYVDRICPSLGGDGMDSEDDGTYGYEYDYGSDGEPGGSVISSHASHASHASSLPVGASAATPGSSSASASASASASASASASASGVGVGVGVGSRTGNGNGNTRAPGPGPGPGGSSRSLASLSVQPQFNVDSASRLLDIFRKVMVWHFPCVLVDHVVCNDETEVEGKVELEEATVASLARERPFVLLAVLAVASSTRTLQGHSLYDEEFRKILGLKFVAGGERSLELLQGLAVYVAWYPFHLRPKNRQAFQYVRMAVDIANDLELDVDPGVDELCGPRRPSPQRLEEIRTYLATYYVASNFATTWNRTPSMSFTSYTAKCCDILEKYSITKGDRILPWLVRLQRLCEETNDLRKSQRGGLPQQTESQIEMIIKGMEAQLNEWEAKMPPDLQSIPSIRITTLFTRLFLTGAPLLKLPFVKLPGLEKGNPPSFRVDPNRLLGLIPTLHQNYEYFLSLSAHEINAFSMIGWGCLILSTILGFRMSFPIMFCPEWDDYAARRVVRFEGFLERLCRLGTTSTSSTSEETDKDRSNLTPATMPTTKGMDVLSASKVVFAVVRRKFRNRVAKLEGAGLGRGKKDKDTRMGGVGVGVGVGVCPVTGKAVGEGGDNPHDHLGEQHHLQPQQPPPPHHHHHQHQTQHLQTPTSPTDFTTTKNHHQHHQHPQSQQEVLDIHMDLSMLPLEVDISQAAPIPTLHIPSTNISGCPMMDGSLEPYYPYWDETFAFNSTSLTGSGGSPSANSLGSVGSGSADTTRNGVASGEHMSGEGSGGGAGVPVGMPTMGSGIGGMNMGMDMGMGYNDLWAAMTMDWAGGGDVENWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JPA1</accession>
    <name>A0AAE0JPA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H65DRAFT_515791</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686575.1">
        <property type="nucleotide sequence ID" value="XM_062828658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JPA1"/>
    <dbReference type="GeneID" id="87865812"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="631"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3355197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1174" mass="130702" checksum="AC1B7B156602EB24" modified="2024-05-29" version="1">MASVLPDPTIDLDWSGYVGSIQEHFRRNAEAHPERTCVVETKTSTTPERRFTYRQIYEASNTLAWYLHKAGITNGDVVMIWAHRSVDLVVALMGILTSGATMTVLDPAYPPARQQIYLEVAQPSALLRIGRATDENGPLAPLVQKYIDDELKLKTDVPDLRLRDDGILYGGEVDGKDIFAEVRQLASAPPDVIVGPDSNPTLSFTSGSEGRPKGVLGRHYSLVRYFGWMAERFNLSSESRYTLLSGIAHDPVQRDIFTPLFLGAQLLVPSREDIQHEKLAEWMREHNPTVTHLTPAMGQILVGGASAEFPSLEHVFFVGDVLTTRDCRALRRLAENANIINMYGTTETQRAVSYFEIPSRNRDPDFLERELKDTVPAGTGMQNVQLLVVNRENREQQCKVGEVGEIYVRAAGLAEGYLGDKAMNDQKFLNNWFVDNNKWVEADAKLNKNEPWRKYYKGPRDRLYRTGDLGRYLESGDVECVGRADDQVKIRGFRIELNDIDSNLSQSPLIRDCKTLVRRDRNEEATLVSYIVPEHKEWLKWLEVRGLADVEDEGVEMGPVTVYLKKYRRMQAEIRDHLGARLPTYAVPNIYVVLKKMPLNPNGKVDKPNLPFPDVAERVEDASEEDLKNWESLTETERTVAQLWADVISGLNPQTIKRENAFFDLGGHSLLAQQFLLNIRKAIGRDVSINILYEHPSLAGFCAQVDKLLGEETSGVTAEAGQDEYAKSLDELLAQLPEKFLSADPAALGSEELTVFLTGATGFLGSYLVKDVLDRTARTVKLIAHVRGVKDSTAALERLRRSLQGYGLWNDEWTGRLSTVVGDLAKLNLGIDDADWADLAQKVDVVIHNGATVHWVRRYHDMMAANVLSTVDAMKLCNEGKPKAFCFVSSTSVLDTDYYFDLSDKQVSTGRGAIMESDDMEGSRTGLGTGYGQTKWVSEQLVREAGKRGLLGSVVRPGYILGDANTGVCNVDDFLVRMLKGCIQISSRPHIVNTVNAVPVNHVARTVVAAALNPIPSGVHVIHVTAHPRLRMNEYLAILEYYGYKTPETSYEEWKDELEKFVSAGSLVKDQEQHALMPLYHFCMNDLPANTRAPEMDDRNAVAVLKADADKWTGVDDSTGSGIGREEVGKFLAYLSEINYVPKPTEKGRPLPQIQPEVLKALAVGATGGRGGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQ78</accession>
    <name>A0AAE0JQ78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_54848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687044.1">
        <property type="nucleotide sequence ID" value="XM_062829584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQ78"/>
    <dbReference type="GeneID" id="87866738"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041914861" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8177" checksum="60EAA69EBD01A04B" modified="2024-05-29" version="1">MSHEVLLLLFVSDIPGFSLEMGVQETKSRDSNSVSASPVNIGRPSWNIRLVFSSSASVKLLSEQNCTLHSPSCPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQP2</accession>
    <name>A0AAE0JQP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-chitosanase</fullName>
            <ecNumber evidence="10">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_66095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="10"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687404.1">
        <property type="nucleotide sequence ID" value="XM_062831237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQP2"/>
    <dbReference type="GeneID" id="87868391"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF6">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041767337" description="Endo-chitosanase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3356027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="300" mass="31756" checksum="6555DBDC60F296A7" modified="2024-05-29" version="1">MLPAIFLALALASLSLSSARDVPLNLQNLYTKLLKQKSCKHPLASGFYSTEDGPNTFSYCADHLSDFQILYIRGRGKGRLANMDVDCDGVQGGAGDDGRCSIGASPDYQGTTAFQETVASYNVSGGVEDLNTYVHPYVVFGNEADNMETKEWNVFDPGAHGVEPLSVMAVVCGDGGSKLVYGVWGDTNGDDGEKAMVGEASLALATACGGKRMSGSNGIDEEDVLYLAFTGTEAVPGAKGAKWDAGSYEEFERSIEGLGDQLIQRIAADGKASGTVRVSWGLMIWMFAALVGGHLGAYWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JQW1</accession>
    <name>A0AAE0JQW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_564570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687076.1">
        <property type="nucleotide sequence ID" value="XM_062830259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JQW1"/>
    <dbReference type="GeneID" id="87867413"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="83"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3355698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="193" mass="22058" checksum="ED02BEA8AC22055D" modified="2024-05-29" version="1">MFITTKIADLVQIAPEDFSKESFVAIEDNINAKYANKVVQKVGLFVCLWDVTWTSEGQIGHGTGLVNVNVEFEMVVFRPFKHEVILARITHQTEEGIYLGMDFFSDIFVPAAELPDNSEFDTTEKVWVWKEEGQELYFDNNEMVRFRVIGEEWHDQTPTGPVEVDQAANQLLPPYKITGSMKEGGLGCCLWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JR48</accession>
    <name>A0AAE0JR48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_73800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687659.1">
        <property type="nucleotide sequence ID" value="XM_062831345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JR48"/>
    <dbReference type="GeneID" id="87868499"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3356282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="182" mass="20483" checksum="6B7E4A5FC776BF72" modified="2024-05-29" version="1">MIRDFLDRTGLIVQQQPSMLNQLPLTCLLPVVLIILGRTLWILHKHLKAIKSQDDPIPLPSDLYLLIGVLVKASLTSFPPSFWLLTSLSTNALTAISVPCVLFFPEIIYTHRLLQLQELQVQGQAQRMVHPRLQTKTWKNTTQPLPSSSSTPHGCPAAVHWYACLLQPLLWNFGISSSVRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JRA4</accession>
    <name>A0AAE0JRA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated potassium channel beta-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_414460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687432.1">
        <property type="nucleotide sequence ID" value="XM_062823917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JRA4"/>
    <dbReference type="GeneID" id="87861071"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3356055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="354" mass="39569" checksum="FE22B03650C7E85E" modified="2024-05-29" version="1">MASDAPVVPTAYEPKDMKFRYLGNTGLQVSLFSLGGWLTYGGTQKGEVVKKCLQTAWDHGIQTFDTAEIYANGASEVEMGQALKELGWPRDEYVLTTKVFFGTGRKEPNTRGLSRKHVVEGLKASIQRLQTPYVDVVFAHRPDAATPMLEIVEGFTQVIRNLNLAYYWGTSEWSAVQIKEAIHLAEKHNLIAPVVEQPQYNAFHRERFEVEYAPLYKDHGYGTTIWSPLASGLLTGKYNDGIPEDSRFATNKAFFENTIKQLQSEEGQAKIEKVRKLTKIAERLGATVTHLSLAWAAKNPNVSTVILGATKVEQIEDNLKALPLIDKLTPEIMEEIEAVLDNKPTPPATYGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJ28</accession>
    <name>A0AAE0MJ28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_512716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676637.1">
        <property type="nucleotide sequence ID" value="XM_062828597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJ28"/>
    <dbReference type="GeneID" id="87865751"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="87" mass="10540" checksum="B11261591B2B324A" modified="2024-05-29" version="1">MCRVGYTYKYCLNGDRCHSNRGWRSRNGELYPVGRYFERAERVFSRPRCNRSDWRHDTYLDGRTSDEYYSSCLAAGETSGDRWYYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJ59</accession>
    <name>A0AAE0MJ59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_76713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676742.1">
        <property type="nucleotide sequence ID" value="XM_062831385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJ59"/>
    <dbReference type="GeneID" id="87868539"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000016">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000770">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="10">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="616"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3334576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="694" mass="77436" checksum="C098E526B774546E" modified="2024-05-29" version="1">MDSYHLAPSRLNDISNDPTDITDQNCDRKRPEQQARLRSRNSVTNMSSVLMSKTVTPFLREHIPSLYAPIGKPGNQETARAENPNSKYCYRHHPDSKCRRAADKAKMVMIQSELDKLTSADQQAVTHVWSLFSAAPARHRDLMLQGILSQLCFPQLSFVSREVNEALKIDFISALPVELAQKVLCYLDTVSLTKAAQVSQRWRTLADSDAVWVRMCEQHVNRKCTKCGWGLPLLERKKLRNYTRQRQLAKGGPQGRITELADSHDSQHQSVNQHGKRPAETEEEDPIKKRQCIAEASKAVTQPKTRSWKAVYRDRWQVSYNWKNSRYKLSVLKGHENGVTCLQLDDNILATGSYDATIKIWNIETEECIRTLVGHTAGIRALQFDDSKLISGSLDHTIKVWNWHTGECLSTFAAHTDSVISVHFDGHLLASGSSDKTVKIFDFNSKETYCLKGHSDWVNSTHVDIKSRTVFSASDDTTIKLWDLDTRQVIRTYEGHVGHVQQVLMLPPEYEPDEEVLNGALQDNQDAMSVSSTGSGSPTMSHAQIEHAGSPGSHSPSYNPLPSSLPSGDDDVRHLYGSAFAADESRPLPSRYFMTGGLDSTIRLWDSATGRCLRTLFGHLEGVWSLAGDTIRVISGANDGMVKTWEPRSGKCDATYTGHCGPVTCVGLSDSLMASGSEDGTIRLHSFKPRPCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJD2</accession>
    <name>A0AAE0MJD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_553577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676803.1">
        <property type="nucleotide sequence ID" value="XM_062829974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJD2"/>
    <dbReference type="GeneID" id="87867128"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="588" mass="65202" checksum="CFD6C01602423D51" modified="2024-05-29" version="1">MGSPGVASFDDAISPLRQAPPDPTPFTYNLWGLPTRLTVFLLALHLFASVKIILRIDRIPGTTFFSLDQHPDEPHDKQAWVTAGTQPFADARQVSTRSIKSPIATRHTAYEQTRTIHKRAAYERSALIRTVYEPMAGACMTFLCLYTQEHARPIYHCDERFPSNVRMDTTRCHEGAKGVTTDTGNREIEHYQSVTRKNKRRARHRSAEHGKVLIQTQAHTSPRPTPCADEYLCCGFTVNVSTLPRRAPHRGRTLPGFAAVAPVEPREGHAKGSTAYYPVFERPRMNNKEDKTQTSEARMGPKAKGSYYSPDALATMVAMLSSTYTDIVTVTIIPATDLITFTATATLTVSAIKTAQAASSPVSIVPLICKPRNNVIAWQTFTSIPSGTSGALTPTWTLDCNEYLELTELESSTKSHLDAQSTECQDSPAVPVDKRTDAITTLEARKISTSAPQPGRCQEEAQGGGSGWPGDKRVYLGRGSQLYQWRMMSLAGDERICSEREVEKSTIKLPPASQHLNPSTRLPPRYNPYLTRMKLTTHHLLSLFIAIAAAAPIDKRGDDKNVVQGMYLAREKTWVVKVEDEVLFDFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MJH6</accession>
    <name>A0AAE0MJH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_436704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676656.1">
        <property type="nucleotide sequence ID" value="XM_062825252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MJH6"/>
    <dbReference type="GeneID" id="87862406"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3334490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="361" mass="37968" checksum="6244BA1AAF11E06F" modified="2024-05-29" version="1">MRAWTLNSAGLTLSPSHPLPSAGAASSTSPSATTPPTITGNNLLLKIAHASLNPVDLHILRLFPHWLPFRRNPTPGFDFCGRVVSAGPGVDANEFTVGDVVSGALGAADVFWGKGSLAEYLLVSSSLVAKKPKTWGAGGKEVTGQEAVGLFGIAGQTAVLMTQTAGVSSAADWKGKKCLVNGASGGVGNILTQILKGKGAEVWGTTGSAEGEELVTRCGGKVVNYKTHNPVTEHLGRLFGEEKLDFVFDCAGSQEMFTKSPGYLKTEGKFISIVGGASQGVVPYIRNKLRPVWLGGTPRAFELLLLIPGKKTVREVGMLVEEGVIERGVVDGVWEMEELVKAYERLGSGRAKGKVVVRVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MK77</accession>
    <name>A0AAE0MK77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_330415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676909.1">
        <property type="nucleotide sequence ID" value="XM_062823506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MK77"/>
    <dbReference type="GeneID" id="87860660"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="411" mass="47011" checksum="802937B985679D3A" modified="2024-05-29" version="1">MGGSIFSSGDDPLYTPRMPPHIYHHVKAACHAALRTMFMCVAAPIEGPEKKDYGDLDILVVMETRLVFPTSPQHGVPRGLEELAADIKTALNAERSIVNPYTNSMHLAIPWPKDDSQLGEDRDTTQRYIQVDICICKSMDQMFWALFKSAHGDAWTLLGSMIRPFGLTADDEGLWLRIPEIEKLDRKKSRVLLTTDPVEVLHFLGMQVEGYWSEPFPTVDAMFNYIATCRFFTVNESSSDPAQDNSSTKRNMKTRPIFRKWFCDFLPRLRADGRFEQQHQSVSDTSDLRVRVRDEAFRTFNVEPNYWAQLKDWRLKKEPEAVKNLIKLAIPDDLDPQFRGSLLSAIKKIVMAKVSLRNDEGFYNKDMTRAFVEENWEDIGKLAFKKYSDAYSAGLQSKKLKNAHGTAIQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMU1</accession>
    <name>A0AAE0MMU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_552766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677748.1">
        <property type="nucleotide sequence ID" value="XM_062829914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMU1"/>
    <dbReference type="GeneID" id="87867068"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="74"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="292"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3338297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="685" mass="76158" checksum="1DC0E40D5DD24D33" modified="2024-05-29" version="1">MSVAMRRLIRATRTLSLTTPHNSLSRGTSIIHLTPSNCHPRTRFFTSSARLTNALSQQIQLRDYQEECIQSVLAAINQGHKRLGVSLATGAGKTVIFTHLIDRIEPRSEKATQTLIIAHRRELVEQAARHCANTYPHKTVEVEMGNVKASGIADITIASLQSIISGDRLLKFDPSRFKLVLVDEAHHIVAPGYLRTLEHFGLRQKQEDSPHLVGVSATFSRADGLRLGAAIDEIVYHKDYVDMIGDKWLSDVMFTTVDSSVDLRDVKKGAGGDFDIAQLSRAVNSEEANDIAVRTWYAKAGNRKSTLVFCVDLAHVADMTAIFRRYGYDARFVTGDTPAKERAEILDAFKRFEFPVLVNCGVFTEGTDIPNIDCILMARPTRSRNLLIQMIGRGMRLYPGKENCHIIDMVSSLATGIVTTPTLFGLDPDLLVEGASVEDMKEKGERRAEEEARKEIVYHSAGSTNPAPQGEWAVTFTEYESVFDLIADSSGERHIRSISQYSWVMIGQDKYVISGPDSSHVKLDRVAPEEEEQGAPRWVAYEVRTLPVSVTSKSPYATPREILKAETFADAVHGADSFLASPAGQGKFPRNFIHRGMKWRDDPATEGQIKFINRTIRRGQEPVEPKDVTRGAASDMITKFRHGARGRFADLSAVNKRKKKQILLLEKDKRLRESVSVGSVAAMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MMX2</accession>
    <name>A0AAE0MMX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_434669</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677466.1">
        <property type="nucleotide sequence ID" value="XM_062825144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MMX2"/>
    <dbReference type="GeneID" id="87862298"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3338015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="425" mass="48913" checksum="97934CD2A193975A" modified="2024-05-29" version="1">MLGIPNLPNKLPSRNWMIFWTVSASITAAIIYDRREKRRNIAKWRHAVEHLAAEPITDKLGLEQPRKLTIYLSAPPGDGLRVAQDHYTEYVKPVLAASGLDWEFVQGRREGDVRAVVADRVRKVRRGWEKKEEQDPDREPTKDELIEMYRQQRGIKDYEGVRGDVVIGRHTWKEYLRGLHEGWLGPLVAPAEPAPLPPTPAPAAAEGSPSTEEKPAEEKKEEEAPKPKRPPQPKPYNTTSDYPSETLHPLTPQELTPAVPIREPHILGFLNTPTRMVRFFNRRSLADDIGREVAAVCLSTYRDFQQQTNPDAPSADSVQYEQAKELEWEEKDWPKKVWKEDEADADKEVTEKIHTKPVVMDPRIAHRMRRFALTPEVEDRVSKIKVPEEEVEGWIKGSLRQAYRWGYDKAFNKKKLVPLEDKDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNK3</accession>
    <name>A0AAE0MNK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of Vps4 activity in the MVB pathway-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_502077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000008">
        <property type="protein sequence ID" value="KAK3338253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677704.1">
        <property type="nucleotide sequence ID" value="XM_062827854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNK3"/>
    <dbReference type="GeneID" id="87865008"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3338253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="299" mass="32491" checksum="CF1592C937FEAA80" modified="2024-05-29" version="1">MPPAGAAFVAKLKVQLKLAIARLRMVQKRDEALAKTQRRAMAQLLDVGKEDSARIRVENIIRSDITTELHEILELYCELLLARAGLLEAPTCDPGLEEAVKSIIYAAPKTEIKELHQVRTLLAEKFGKEFALQAVENSDGKVSEKVVKKLSVTPPREELVVGYLEEIAKVYGANWPKKKADLGDPPDVMDDDENPSGGQAQKNLEAPLKAEDKEAEAQEELSKATPPVSFGPASPLHVNPPPPSTDNIHPKVTLNHQQLQPKQPPASGGVVKKAPAKGSIADGIPDVDELAKRFAALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNR2</accession>
    <name>A0AAE0MNR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_551729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678336.1">
        <property type="nucleotide sequence ID" value="XM_062829839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNR2"/>
    <dbReference type="GeneID" id="87866993"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3338976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="74" mass="7685" checksum="89E076A2A485E603" modified="2024-05-29" version="1">MLVAVPVVIVGRSDQAVLARDSKRDPAFWNMPPECAATRGTVGVGVVMAVEEKEEGVASADEKVVGPPIVVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MNY7</accession>
    <name>A0AAE0MNY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_282396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000007">
        <property type="protein sequence ID" value="KAK3338764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062678124.1">
        <property type="nucleotide sequence ID" value="XM_062822898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MNY7"/>
    <dbReference type="GeneID" id="87860052"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3338764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="574" mass="62599" checksum="855BF79AE832F63B" modified="2024-05-29" version="1">MPDLIIPPLLSPIPSPVWLRYFSINQSNINSRTAEEMPRHTRGPAAGVLRGIPINDWSEGHFEWHREGCDCVVKLCPQHCRELVGSNDHDEGPEVSGRNDVDDNYDGEDDNDGTRHSDEDHDGRNSIPSTSDDDPKDSIPSVLPSIERGNQSGSGPPSLSASPEEIAQDDPEATISPENRDEMESPVQRPEQQPPPAALTINADYLEALSPGFRARLVTYVEAISEELRAYILPQAPASTASANPPTRLLAVYQPSRHLAREIRHLIREAQALYPLSDSVTPDPRPGPGGHLQRSPSDILAHVLNTSPSPRVKVGPSGSGSASQAVRGGGGEGSVGSSATSRTPAQPQPGPSQPMPQPSMGVFFTSAPKAVARRLFSRSDPSQRPSQRQQPPQLEPRPTSSTPANTTTTTRRRAPDPQPPNVRQPLSEPAPAPAPAPHPARPPPNMSSPPQQQQQQQQQQQQQQQQQQQQQQQQQQQPPRSSTSAHKKTLPASRASSRPINEQDEQEEQDIQGEPSGSNVDSRQLEEESSNLSELEEESAEQDELAPTRPKRGRPKKSGSTVTYGKRGNKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPA6</accession>
    <name>A0AAE0MPA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_472314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679367.1">
        <property type="nucleotide sequence ID" value="XM_062827143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPA6"/>
    <dbReference type="GeneID" id="87864297"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3340425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="184" mass="20352" checksum="2606590ED4B97028" modified="2024-05-29" version="1">MDEAATVQECLGKQHGGHHHRIWHQSGTPGLRTPCSFHTFLLCFLMFFWSSARSGKSTTLLPTIPLLSADPTDIAKPKADHGQIIIAKRSMNGRREDDIQCLSTTSTPHCGHHRRLRSSATYRLQHCFVSGIPNSLHQTDLVSATWTNAIAMGSADEPGQSHQSGSHAPIRIYGLLNRDRLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPU1</accession>
    <name>A0AAE0MPU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose inhibited division protein A-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_444509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3340504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679446.1">
        <property type="nucleotide sequence ID" value="XM_062825686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPU1"/>
    <dbReference type="GeneID" id="87862840"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="10">
        <location>
            <begin position="760"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3340504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="880" mass="97007" checksum="EBF62BED7FCCEAA4" modified="2024-05-29" version="1">MSAFLRPVFGAAARPAVRSFSSTSARGLARVQIIGNLADTPEVRATSTGREMIKYAIASNSGPRSSPLTSWFNITSFAEGKARDFLLTLPKGDRTTVFVEGELSLRNWSDEEGRNRTSVNIVHRSLEVLRRPYTGPRETTETETETEGETQEQQFQQDASFRLHRFHAIRATSAMSKLLISRSLGRPLRRPRYQFWSTGIIKTRTFATVESDARPFDVVVIGGGHAGSEACAAAARAGARTALVTPSVENLGVASCNPSFGGIGKGIMIREIDALDGLAGRIIDKAGVQFRVLNRKKGPAVWGPRAQIDRALYKKHMRAELESYPNLSLVYNSVSDIVVSENDDPSTGARTKITGVRLESGEVLPTSQVIITTGTFLGGEIHIGMEAYPAGRMGEKATFGLSKSLREAGFKLGRLKTGTPPRLDKKSINFDILEKQYGDDPPNPFSYLNDAVAVKDQLHCWATYTNHATHEIVRANLDKTIHIRETVKGPRYCPSLESKIIRFSDKERHLVWLEPEGFDNDIIYPNGLSMTVPAEAQLALLRTIPGLEDVVMTQPGYGVEYDYVDPRSLKRTLETKAIRGLWLAGQINGTTGYEEAAGQGIVAGINAGRAATGLEPVTLSRADGYIGVMIDDLITKGVSEPYRMFTSRSEFRMTTRSDNADSRLTALGRSWGVVGDRRWSHFQSENGQMAELRRILSETILSPQAWQNAGFDVKADSRRRSALEILCFKGASIEKLHESGVVPKLMEFSERVRERTFIEGLYAPQIEKHELERARFEREEDLRLPLDLDYDQIPSLSLAEKGVLKATRPESLAQARRIEGITPAGCMRLLAYVKRRNRLGIASELSSEAPEADLDAVGEALTAAEGDMETVDAKARAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MPW8</accession>
    <name>A0AAE0MPW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_279624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000006">
        <property type="protein sequence ID" value="KAK3341040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062679982.1">
        <property type="nucleotide sequence ID" value="XM_062822860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MPW8"/>
    <dbReference type="GeneID" id="87860014"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="277"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="379"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="517"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="557"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="597"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="639"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3341040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="753" mass="82804" checksum="A8BB8ABF433CEAF1" modified="2024-05-29" version="1">MATHARATASMEEAQSPRAAESSTKTNRRRGHSLSVSPLWHNAKSTTDNHGPRDSTLQHSIFGQNHGPFRSHRQNSAASDDSVPAHHKQGHKLKGMLRRASVSFRSGVKGIVNRRTSVPDTPTFDQDVGAGPSQSAQARPTTAHLTWNKLRQATSFHRHSRRVSAHHGEYPFGFNALESPPLPVPGSGEQPPIIPRNTGAAARQAAASAGHGFEMINIPAPRPWANDGMDDYESGIGIAVTRGGSSESDVFMDGVDSDVDIELNSPSPNDEVDIIKVDFISQLPLELGIHILGQLDATSLASASLVSRSWNRAARNQHIWRESFLREKTTTYATSGAVKPGTGLGVPAIRPGNDWKEIYRVREELDKRWKEGKARPIYLHGHTDSIYCLQFDEHKIITGSRDKTIRVWDMKTYSCKLVLGPPEIINDSDLSLLHDEAGNAIHHATLPELEPHPSANGQLQTPARSHFSSPALISPPIFHRASILCLQYDDEILVTGSSDATCIVYDIASGYQPVRQLRHHSAAVLDLVFDDKHIVTCSKDVSICVWDRATGALLKQLRGHTGPVNAVQMRGNTIVSCSGDFRVKLWNIETGKQIREFLGHTKGLACSQFSEDGRYVASAGNDRVIRIWDANTGECVREMKAHGDLVRSLHVDSVSGRLISGSYDTDIKVWDMDTGAQLLDFPQWHNSWVLSAKSDYRRIVSSGQDPKILIMDFGADVKGIEMLETAGPQIHPPRQQQQQQVVVPSEQGQGGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQ76</accession>
    <name>A0AAE0MQ76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_549682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680268.1">
        <property type="nucleotide sequence ID" value="XM_062829674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQ76"/>
    <dbReference type="GeneID" id="87866828"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3342475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="33904" checksum="5F7A0B1EDD428CB3" modified="2024-05-29" version="1">MSVPVTASPATAPPIDVSNLFSVKGLVALVTGGGSGIGLMLTQSLASAGAKRIYIAGRRLSVLQSAADRINSSLPSTKEPVVVPLECDVTSPTSLSSLVSTISSDPYTGYLNLLLCNAGVGGPQVSAVNKETGEPKTLKEFREQNLAVDFDKEWEQTFRVNVGSVWYTAMACLELLDKGNQVAATEGVKEGVWRESSSQIVVTSSIAGLNKAAPGGWAYGVSKAAATHVGKQLSVLLPRWGIRCNVICPGLFPSEMAAPIVQAAGGSMTGGGVIPLDKKIVPLGRMGDEFDMAGQILYLASRAGAYLNGNVIVVDGGRLTTMPSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQM5</accession>
    <name>A0AAE0MQM5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H65DRAFT_509612</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680316.1">
        <property type="nucleotide sequence ID" value="XM_062828332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQM5"/>
    <dbReference type="GeneID" id="87865486"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="389"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="570"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3342523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="750" mass="79053" checksum="16920E079D8192F1" modified="2024-05-29" version="1">MFRAAAAGPYDEAINKATDENLTSEDWGAIMEVCDRVATDANGAKEAVNSMIKRLAHRNANVQLYTLEVSNALSQNCGKNMHRELSSRAFTDALLKLANDRNTHTQVKAKILERMKEWSDMFKSDPDLGIMYDAYYRVKQSNPTLQPPSAPQKNVLTDADRQKEEDELQMALQLSLQEEERKKRPAGASGATASSSGGAAAGPSNAGAGGASEGRTNSTAGQAEATPQSVPSGTTAATVSRVRALYDFVPSEPGELEFKKGDVIAVLESVYKDWWRGSLKGKTGIFPLNYVEKLTDPTPEELQREAQMEAEVFAEIKNVEKLLTLLSAGNTGPREEDNEEISKLYHQTLAIRPKLIKLIEKYSQKKDDFTQLNEKFIKARRDYEALLESSMSHPPGPTYHQYAMRPPMTNSYGSGGYGAPPPQQQQEPPRFYTPAPVQDAPQYPVTSPSPNPNHFIRPAGTPAPYYMGGAEGPGQHQQQPPYPQQQPQPAYGGPSRPQDQRIPSGSNPMAPAPLNTTSSPPPGNQYAPYQPPGASGANNRTSSYSSANGGAPQELSTSAYDSPIAQHSTNPLSNPSYNAPSAPSYNQGAPGAPTDDPYAPASPTAPAPGAGSSSNVGSAPLPPSGPAPSAPSAPSAPSAPDGYAQGGYHTQNPYHQAAAAAAAAAASSRTHTGYDGAGSEVSSTAPPPAALQPGGGAQHQYKAYVPPGAPSAPGGQGQGGAEGPSAPGLQGQGQGQGQNDGLADYYRSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQP7</accession>
    <name>A0AAE0MQP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_429085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3342969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062680762.1">
        <property type="nucleotide sequence ID" value="XM_062824799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQP7"/>
    <dbReference type="GeneID" id="87861953"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3342969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="514" mass="57296" checksum="F2776698BAF4EBC7" modified="2024-05-29" version="1">MAPSKSKKPKKQTAVTISPVLRRFELEDVFINQRHNNFKDPQLVLKSQLDRSRGMPYNAGVNSQMPIWHHQLMIHVKDKADELAKLDLEDFTPAAKARDPPSQCTAACSPSERAFMFWYPMGPERASLLFSMKSTSDFEAVLREMKRWEVTMASSRHGFGHSFWIRREQQGLPSIPQINPLTVTKSSSRRHRKYITNAHPGLLIDTNNPHLLHSVSSAGQFFASPQPIQHLSQPFYLQQPQQALVPGSLLQRSASTIAVPGVLGEGVYKISKVKSNPIGRSRVRRLSSSKAGEAAPTYLTRPRIARQPSGLSSGIVNFNHDSPAVQLQPRPPINIPKMAKHFMAGLTEATMIWNEHMRRGKEESDLVSDLKEKIRIWMRHARVCQRDLNEVDFATKQRMRGQPVGTGTLRRMSKSGVGSRFHPSVPFTSGKPMVRSTRQPVEIPPASAETFSLGVPSPILSSRSTVISSHSDLASIPNSRFALPTHFPSLTATTQNSPSPTNSWGERAFTGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MQZ3</accession>
    <name>A0AAE0MQZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H65DRAFT_244853</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681063.1">
        <property type="nucleotide sequence ID" value="XM_062822372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MQZ3"/>
    <dbReference type="GeneID" id="87859526"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042211949" description="Extracellular membrane protein CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="26"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="18">
        <location>
            <begin position="136"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="407"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3343270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52220" checksum="30BE548FDEC27B80" modified="2024-05-29" version="1">MGSLRTTVAILGLCLFLFFTNVATAEKIIETPPISIMEALEGLPECALTCLVDTVNSVGTCGTLTHPVPNLADCVCHSQQINDVSAACIHGACTVKESLTAKNITSYLCHEPIRKNNTIIPVLAVFLGLALFAVVLRVLARVLTRAYFWWDDLCNLFAFIGCICFSTLNFESVNHGYGIDIWFVKFDDITTILRLFYANMLLYTVSRFFVRASIILFYLRVFPKDNKLSRILTWTMVFNVVYNFSFLCAVIFQCHPIKEFWLQWSGETKGHCNNVPAIVWSAAATGIIFDVWLLVLPFPQLFALNLHWKKKIMGSLMFSVGASVMIISLIRLKTIPTFTRAENPTKDIADLCIWSGVEIDVGVICPCLPSMRLLFRKLLPSLLGSTNKYELEPVSASASTAINRSLARKSKPMFNEPTTTDHGHDGSSIGTKFTHDDDHPSQRHGASSESVTELVTDSDEDFKKMGSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MR27</accession>
    <name>A0AAE0MR27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_429369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000005">
        <property type="protein sequence ID" value="KAK3343329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681122.1">
        <property type="nucleotide sequence ID" value="XM_062824819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MR27"/>
    <dbReference type="GeneID" id="87861973"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF8">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3343329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="78057" checksum="CFC66579964E6A99" modified="2024-05-29" version="1">MSNLKFDFVQALKGAKGLGASWRLPEFKTLGQKPESEFRVLEDKHHNEEESVFEPDNREIIPPGDFADGGKYRSIVKISMRYEGMGEDDDRWAIGTGYLVAPDVLITAGHCVFHHGDGGQGLGRLTHMRCFIGYDGKNSVGKSSVQFRTAIMVVTTAKFVIDGARSSDVAIVKVDRAFEGNLNLFKYQDTPLKATAFLGIVGYPGDKQMNGERGAQMYGLVDEVTYDLATSQKNMLEYRISTAGGQSGAPVLKFKLRSGQIVPDVVIGTHCYGGSGKNSASVIGGQYGNDYKTLMDGLQKNGSLYITDISKGLPGVEPGPDPSPEPVAEGFLDILKDIGRVVTPIAQQGLSFASPFLGPLGGPVSAIGGIALGALSKVCEESALDEDKTPSYKLQDGVAQRAVLAEAALQTVLRMERSPANKRIMDSMTAKYQGSGFDADKANKLGAKLVPLMSQAGLHLAINENLVTNKKQATGVQKIKPHGPELIVPSADTQVEDFLDAAAQAEVKTWRTIGKEDKSEAEFFNDLTQFLATGSQAPKPALISGNPADLTPGQKQLEAYLSKKSGNEATDLPVRPSPTDKSRPISDAHAAGYLAHRAIVAECALQAVLEAKKTDLQDSVILGDATSAEPESFFDGLLKTVQMMGSAVVKVAPKVLDVALPILIDTVKSHARAESIFDDTPSVPVGPPAPPRFNGVSEAAVKVNGASADGFVNGIEKNPDAPPFIPDHLAPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MRV3</accession>
    <name>A0AAE0MRV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H65DRAFT_442799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682038.1">
        <property type="nucleotide sequence ID" value="XM_062825597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MRV3"/>
    <dbReference type="GeneID" id="87862751"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="717"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3345425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="798" mass="87709" checksum="BE4070E37F8E2EF3" modified="2024-05-29" version="1">MTVVHTLTPQGSSHGIGSGQALEDRFEVLKEIGDGSFGSVVLARVRSSGATVARRGTVIAIKTMKKTFESVGPCMELREVVFLRTLPAHPHLVPALDIFLDPFTKKLHIAMEYMEGNLYQLMKARDHKCLDNSSVKSILFQIMKGLEHIHAHHFFHRDIKPENILVSTSSHMDTQNSFRRYSALMNPPSTPPTYTVKIADFGLARETHSKLPYTTYVSTRWYRAPEVLLRAGEYSAPVDIWAIGAMAVEIATLKPLFPGGNEVDQVWRVCEIMGSPGNWYNKAGARVGGGEWREGTRLAGKLGFSFPKMAPHSMDTILQTPQWPTSLAQFVTWCLMWDPKNRPTSTQALAHDYFTDAVDPLRPKSSASRILGRKQSDISRGKDSATSTPTSSKPSWFRKSLIGRSESSTEVSTVSTTQENAKVNIAPRPSPVQVAPEVPSPKPRPAPAVSKRTTWNNGPSNVAPMPILPTIRPITPLSDAVTAQASSRTPSYNDAYVNGTQRSAADENKASKKIGRQLSVASATNHYAEIHRQQAERALNGQTGLASPTSGTKESFFSHLRKRARRFSGRHQTPMSPAYDDIEAQPHGVGCGPWGSNRSSMVIDNPPPAPVPKDTLESLEKTLRDPQPVAEVPPMPAAHRAPPQSTLKRHHSLPHHQPRSVDNLMMSARGSGPVSSRTRRQQAAQGVNQYDAPDEEDELIDEALTSTRKAIQRLEKDTKHLRQSASNLGLTNPYLTPSPSASGQNIFFADHGKKALTPQSLEQNKRSSEYKWPTPPYNDEGDWAASASASIWAAGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MS99</accession>
    <name>A0AAE0MS99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_465362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062681664.1">
        <property type="nucleotide sequence ID" value="XM_062826803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MS99"/>
    <dbReference type="GeneID" id="87863957"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3345051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="462" mass="48112" checksum="69EA8F82DC79BE01" modified="2024-05-29" version="1">MFMRARRRGGGRGGNGGEKEGGEVVYVGPGSSDGSGRDTVGSRGSSNGRRTETRENVKSYPGPVIWVASTDNTSIAGSGTRVASPSTSTSAIKLSDYEDESVYNDGEAGGPPPSSRGGSLMEGRTALSPPPPAIPPRARSRSRPAPGEAGAPPAAATFPFAAAENPVPPAPAPAPAPAPSASALLSPFPPRPKSVRTGVGTGPVKLKDRRQSSGDEARGVGYAVSYYSPVPPPPVRAAPRVPKWAPPTIPGYGDDAKPLGSGSGFKLDNPPPPTTSMNKKKPRDTRRLSIFPGPSPSPTPSTQGWSSSPLSSSPSTPPVPNRADAAGIDRSQRRTGTEGEEEEEEENERRGRPSQKRQQQTQTQNQGTSSTNGQTKSPSPAPTLEAWLKRGMSSTRVPVRTGTGTGTAGPGVSLPRSASTSNLAVRRQSYTARLREQVQLQHLMDADDGNGGRGEDWPIRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSM3</accession>
    <name>A0AAE0MSM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H65DRAFT_205182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000004">
        <property type="protein sequence ID" value="KAK3345411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682024.1">
        <property type="nucleotide sequence ID" value="XM_062821859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSM3"/>
    <dbReference type="GeneID" id="87859013"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="152"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="252"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3345411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="344" mass="37271" checksum="A667DAA80236DAB7" modified="2024-05-29" version="1">MQAVTTGLGAPSPSDSKYTAASVTKPAAQAIMEKQTTSDKPVVAATTTTTTTTIKSKQQTIHYPFWFGGSASSMAATVTHPLDLVKVRLQMRTGDAPKSMSGTVVHILRHHGITGLYNGLSASLLRQITYSTTRFGIYEELKTRFTTKDSPASFPLLIAMATVSGVAGGLVGNVADVLNVRMQHDAALPPAQRRNYAHAIDGLARMTREEGFRSWFRGVWPNSARAAAMTASQLASYDVFKRILIRHTPLEDNLATHFSASFLAGVAAATVTSPIDVIKTRVMSASGKSSIGQVLGSLYAQEGVRWMFKGWVPSFLRLGPQTICTFIFLEGHRKMYKKVKGIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MSR2</accession>
    <name>A0AAE0MSR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 71-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_587406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3347424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062682506.1">
        <property type="nucleotide sequence ID" value="XM_062830974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MSR2"/>
    <dbReference type="GeneID" id="87868128"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3347424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="502" mass="54443" checksum="32B20FFB5EB337FA" modified="2024-05-29" version="1">MIIGLTLNQTSDQWKRDIRLASAASIDGFALNIGAADHFTFSSLHTAYEAASTFDNNFSLFLSFDFSASSGSTNGGWSVDYIANLTNSFKDEPAQFKIDGKPLVSTFEGVDFREEWREVRKKVEGDIVFVPDWSSVGPEGVRERVGDVDGAFSFDAWPRPSQSTLTTFSDDGYLSALSNSSSPPNSSNSKSTSPNNNNNNNNNNNNNNNNNKIYMMGISPYFYTRVSSYNKNRYSPSDTLWPTRWSQALALKPDLLQIITWNDFAESHYISDLVVPSQILPEAQSYRRRKGLTDEEWPREKLGDGVVAAWYRTTLVNVTACADGGTKWGQSGEKSAKEAVERDVVNVLAVVRRDMEVVVSVEGTRKKVVTKVKKGGARFFQVGFEELGLGPGQGNKKGGRKVRIEMNGEVREGAEVRDECPESGVINFNAATVYIANSTHPDTGSDSGGSGGSDSGSGSGSGPEDGKGDGDEDSDENAAVPGRSVGVTAALMAFIGFALFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTJ5</accession>
    <name>A0AAE0MTJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC-2 type transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_91541</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683868.1">
        <property type="nucleotide sequence ID" value="XM_062831561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87868715"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1109"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1175"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1220"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1253"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1373"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="71"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="772"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3350573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="1402" mass="156003" checksum="52C09B9A043B9857" modified="2024-05-29" version="1">MGVPGDSNSSVAPTQEENEVNNRQWGLQHKVEAQKEREQSSGIPPRELGVTWKDLTVQVISADAAIQENVLSQFNIPKKIQEGRQKPPLKTILDSSHGCVKPGEMLLVLGRPGSGCTTLLNLLANKREGYVAVTGDVHFGSMDAKEAHKYRGQIVMNNEEEVFFPTLTVGQTMDFATRLNIPYKIPDGAASPEEYRKENMDFLLEAMGITHTQDTKVGNEYVRGVSGGERKRVSIIECLASRGSVFCWDNSTRGLDASTALEWAKSLRAMTDVMGLSTIVTLYQASNGIYDLFDKVLVLDYGKEVYYGPMKDARPFIESLGFECQEGANVADYLTGITVPTERVVRSGFEKTFPRNADQLRDAYQKSEIYPRMAAEYNYPTTEEARERTRQFEEGVAVEKNKHLGKNSPYTVSFFEQVKACITRQYQIVLGDKPTLIIKQASTLAQALIAGSLFYNAPDNSGGLFVKSGALFFSLLHNSLISMSEVTDSFSGRPVLLKQKGMGFFHPAAFCIAQVAADIPVILLQVSVWSIVLYFMVGLSMNAGAWFTYWIILIAATMCMTAFFRAIGAAFRTFDAASKVSGFMISALIMYNGYMIQKPKMHPWFGWIYWINPMAYSFDALLSNEFHGNTIPCVGINLVPNGPGYNDLEHQSCAGVGGAIQGDNVVYGDNYLKSLSYAHSHVWRNFGIIWAWWALFVAITIVATTKWRPLSEGGPSLLIPREKAKIVKAIQNTDEEKAGASSSGEETVYDKEASAGEAKDSDKDLVRNTSVFTWKNLTYTVKTPSGDRVLLDNVQGWVKPGMLGALMGSSGAGKTTLLDVLAQRKTDGTIKGSIMVDGRPLPVSFQRSAGYCEQLDVHEPFSTVREALEFSALLRQPREVPREEKLKYVDTIIDLLELHDLADTLIGRVGAGLSVEQRKRVTIGVELVSKPSILIFLDEPTSGLDGQSAYNTVRFLRKLADVGQAVLVTIHQPSQQLFAQFDTLLLLSKGGKTVYFGEIGDNAQTIKDYFGKYGAPCPEETNPAEHMIDVVSGSLSKGKNWNQVWLESPEHQAMTEELDRIIDDAASKPPGTQDDGHEFATPIWEQIKTVTHRNNVALFRNIDYINNKFALHVGSALFNGFSFWMIGDRVSDLQMRLFTVFNFIFVAPGVIAQLQPLFIERRNIFEAREKKSKMYSWIAFVTGLIVSEIPYLCVCAVLYFACWYYTTGAPHASTRAGGTFFVMLMYEFVYTGIGQFIAAYAPNAIFASLANPFVIGLLVSFCGVLVPYQQIQVFWRYWIYYCNPFNYLMGSMLVFNLWDKKIECHAEEFAVFNPPNGTTCGQYLTDYMMGMGRATNLINPEATEGCRVCEYTSGSDYLQTINLKTYGHGWRDAGIVVVFVASSYAMVYALMKLRTKQSKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MTR7</accession>
    <name>A0AAE0MTR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_167318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683239.1">
        <property type="nucleotide sequence ID" value="XM_062821320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTR7"/>
    <dbReference type="GeneID" id="87858474"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF3">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042244567" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="379"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3348157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="486" mass="51449" checksum="DD9927BAF572F9A3" modified="2024-05-29" version="1">MTKDLKTAVTTALCLTAALPASGAVTFSLPSKVGTGGYAYAPLDPAPIGISFEFFAFPSYFINVTATQQCLANWKALTGVWPPIRIGGTTQDRAQYDAKTSAYVVYSVADAKDAPSVLTFGPKFMTLAGMYGGSVVVGLNRGKNNIDNTIAAAKVAVSEVKHLLAIELGNEPEYWVKDGQPITSGVNWTPATDAASQNNWNIRVGSAVDRTNIIQAGNWNDAPPKWGAAQLIATENATVKPHVRHYAHHNYPGGSIQSLMTHSTIAKNIHTFDADIAAARGVGKEYVFGETNSVSGGGAARVSPTFGAGLWTMDYALRATYNNMSRTYFHHGTVGNCQYCFWGRYSMGAPYYGAYAAVALMAGASHLTALDSGSTNYAAYATFDSRGLPLRVLLYNSDYFAGSGTRTAQSFTLTGLTSSMVRAKRLTAASATSRVDQASPPSFGGQQFDNGSCAISGTETFETTPASGGQATFSVKATEALLVYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAE0MTZ8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_567025</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3350456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683751.1">
        <property type="nucleotide sequence ID" value="XM_062830344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MTZ8"/>
    <dbReference type="GeneID" id="87867498"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042168678" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3350456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22414" checksum="CF7788C100BA6806" modified="2024-05-29" version="1">MLNPLLISHTLLATTILQLLPISVAAIPTVPKSTTNRAPFNSANEGPIHDYTIEPITFQIPTSPSLNSPTINVTGTIQQAIQAAEKVNPAWRSDFAQATIQKFKSQNLLAAVEVDHWDCSTGAPTGYNDVSESLWAVALTKGKPSLGPGRCGRGLARKELDSYGTITNAAYEILDNCPVSDEALGPKRLIHGQVYLVGEWHVVIGGDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MU89</accession>
    <name>A0AAE0MU89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spo12 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_546275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684512.1">
        <property type="nucleotide sequence ID" value="XM_062829438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MU89"/>
    <dbReference type="GeneID" id="87866592"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="144" mass="15382" checksum="6737B5BF570FDA12" modified="2024-05-29" version="1">MSSNTVLFPKDANMAMDTTTPGEPMDITTEQKPTLFAAPSADNKATDTSAAINKSDSMKTLEYHRQVLQNKMEIDHTKYVSPSDNIMSPCTAKLSAFRSKQAGKVKPKSLFAQASAKKLEGTTATGNTGTTGTTNTGLFGVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MUH5</accession>
    <name>A0AAE0MUH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H65DRAFT_548022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000003">
        <property type="protein sequence ID" value="KAK3348233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062683315.1">
        <property type="nucleotide sequence ID" value="XM_062829551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MUH5"/>
    <dbReference type="GeneID" id="87866705"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="94"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3348233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="432" mass="48531" checksum="C4E3D0A557C7A830" modified="2024-05-29" version="1">MATAAVQVSAPGPVGQPDIGYTPDHDKYLERVKRRRETEKLEQSLPPGFPQRLDSDLVWDGNNLAETYDWNYRLTEEDINEIESALRHFKSLNKPLGYITQETFPLPHLHHTLRSLSHELHHGHGFKVLRGLPVTAHTREENIIIYAGLSSHVAPLRGRQDNTHLGQPADVVLAHIKDLTPTVSDINKIGAPAYTTEKQVFHTDAGDIVALFCLGEAAEGGQSYLSSSWQVYNELAATRPDLIRTLAEDKWVADEFGKEGRKFSVRPLLHYQPAASGSSSTEGKAEKPERLIIQYARRTFTGYWGLPRSADIPPITEAQAEALDALHFTAEKYAVALDFRKGDVQFVNNLSVFHARAGFRDDPEEDGEKQRHLVRLWLRDPEHAWETPEVLRERWERVYGGVSPEKEVFPLEPRIRSASRGESVGTQGGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MV06</accession>
    <name>A0AAE0MV06_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_418773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062684604.1">
        <property type="nucleotide sequence ID" value="XM_062824160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MV06"/>
    <dbReference type="GeneID" id="87861314"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3351309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="87" mass="9755" checksum="8B9E85735760E90D" modified="2024-05-29" version="1" fragment="single">SSSRTKISASERPSTSSTSYLPHPLLRVSKKLDALFFDPSPNQGPEYSPNRQLPHRTSSAVLPLTEEESRRPRQIAQGSVSYRHRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVA4</accession>
    <name>A0AAE0MVA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_7364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685667.1">
        <property type="nucleotide sequence ID" value="XM_062831340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVA4"/>
    <dbReference type="GeneID" id="87868494"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="233" mass="25801" checksum="B64754ADE1A79B05" modified="2024-05-29" version="1">MAASESIVKHTLLLSRIVSREFREHNNCTRGPDGFIDPDSCYVPFWYTRTGVIVKWSLFLGLSTFFGLYLILGYLHAKRRMTKGQPPMAYHRWLVARHDLARVDPRYPYPQTTFQPYSQGQQQPYGNYGMHPVPPPVYDPDAPRPPMYPGPPPAMAMAMVQPPDGATKVDPMQQALAPASVPVLPPLYSGRNDGNGGGEEQYEAPPGPPPSAQAQVQGPIRQQGTGGTNPFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVH5</accession>
    <name>A0AAE0MVH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_15747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685892.1">
        <property type="nucleotide sequence ID" value="XM_062821179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVH5"/>
    <dbReference type="GeneID" id="87858333"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042143569" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26775" checksum="0A241C24884117CB" modified="2024-05-29" version="1">MGMVGPLSLALVVATIPLMGHPRFFGGIWSTYLRVTETGQPASRFEELVLRVLPNLMFDNCMSVMSVSLDSPWFRRRVMKTRQSMRLALLASQKRKAIQKVHGNSRAKTSKTIPDESSGSSGTSLGAMARMKNRKIRCVRPIVVDPGGSSRRQRKEEPCFLDSTCVQLVISKTKHELVQIMECKPWLEIGVPYCGPRVNDIYTLPEALLTLLSVHGLDLPVGEEGESVFRTREIVSEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVL9</accession>
    <name>A0AAE0MVL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H65DRAFT_139637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685219.1">
        <property type="nucleotide sequence ID" value="XM_062820915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVL9"/>
    <dbReference type="GeneID" id="87858069"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="188"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3351924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="379" mass="42499" checksum="F669F08FAD07A49C" modified="2024-05-29" version="1">MNGYDEKRQLDDDAFGAKGGSIVSAFDAFPKSKPQYVTRTTAGGKWTVFVTLISFILFWSEASRWWRGSESHTFAVEKGVSHSLDINLDIVVKMKCQDIHINVQDAAGDRILAASKLHRDPTVWQHWVDNKGIHKLGRDAHGKVVTGEEYLQGHDEGFGEEHVHDIVALGRRRAKWARTPRLWGATPDSCRVFGSLELNKVQGDFHITAKGHGYMEFGQHLDHSAFNFSHIISELSYGPFLPSLVNPLDQTVNIASANFHKFQYFISVVPTVYSSSGKSIVTNQYAVTEQSQEVTERIIPGIFVKYDIEPILLNIVEERDSFLVFLIKVVNVISGALVAGHWGYRISDWCQEVWGKRRRRAGGPSEGMLGGKGGQERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVP1</accession>
    <name>A0AAE0MVP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_416014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685536.1">
        <property type="nucleotide sequence ID" value="XM_062824017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVP1"/>
    <dbReference type="GeneID" id="87861171"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000103">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="296"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3354158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="449" mass="51723" checksum="DF17C7B6E1B196E8" modified="2024-05-29" version="1">MDQSVFRITKELSDLQKDSDLSLAVACRDVDVRNVRAMIIGPHETPYEFGFFEFAFVFNKDYPRKSPQVQATTTNEGRTRFNPNIYANGKVCLSILGTWRGDRGEQWSAAQGLESILLSIQSLMSMNPYENEPGFEDAKEAQDQKNQKDYIQKIRHETIRISVVHRLEEYLGINPDGTVGPSNVNGEIVSSGSTESDMDILDEESMVPFEPFKDLCKRRFLWYYDSYLAAVEKGKSEVKDNQSFARMPFESHGNGMEGKFNYTELEKRLRVIKAALDAETEGWAAEGLQAKAQETTVAVNLQRQFEQVVEHFKRRDLAHSIELMDGNPFVWVVTYFGKPMTNLDGGLFRIKLCFSPRFPEEQPRARFETKIFHHRIAADGTPCYYAPQNRREDVRTHLEAIIDALEEESPPYDPRTLVNPEAFKLFWGSADDRKMYNRRLRRSVQQSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MVZ6</accession>
    <name>A0AAE0MVZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear architecture-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_29922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686313.1">
        <property type="nucleotide sequence ID" value="XM_062823129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MVZ6"/>
    <dbReference type="GeneID" id="87860283"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1780:FF:000004">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor nar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="9">
        <location>
            <begin position="125"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3354935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="581" mass="62007" checksum="1613217E6DF62061" modified="2024-05-29" version="1">MSAILSVDDLNDFISPGVACIKPIETLPTAAPAASDANPSNEFEVILDGQQPEAKSNAPPAEISLTDCLACSGCVTSAEAVLVSLQSHNEVLNMLDSAPALKLVGPGADGKYSVEGLENSDGKLYVASVSPQSRASLAAACGNGVTEQQASRMIEQLFLGEQGLARGGKWGNKFTWVVDTNTARETTLVLGSDEVLGGSIAPSDRAATPVLTASCPGWVCYAEKTHPYVLPHLSRVKSPQALMGTLLKTSLSRILNISPDRIWHLAVMPCFDKKLEASREELTDAVWAGDGKPGRGVRDVDCVITSKEILMLAASRGLDFFGLPASAPPQTPRFPDPSIHDFLFRPGHRQQSREAGTSGGNMHFILRHLQAKNPGSQIQTVPGRNADVVEYKVVAKSGEVMFKAARYYGFRNIQNLVRKLKPAKASRMPGGKPFGSAKRPAGKGNGLDYGYVEVMACPGGCTNGGGQIKVDDPVVVDRKGLAVKPGPLEQKEWQKEVDEAYFSGGEPDSGAQDDSSDPDVDGISPSHIRNVLTHWSTLTGIKLERLAYTSYREVVSDVGKEKKMTDTERVVQLAGKIGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW11</accession>
    <name>A0AAE0MW11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tho complex subunit 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H65DRAFT_450524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686417.1">
        <property type="nucleotide sequence ID" value="XM_062826008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW11"/>
    <dbReference type="GeneID" id="87863162"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3355039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="394" mass="43273" checksum="A670608423A6A54C" modified="2024-05-29" version="1">MASWGLLDDKEENELHKSRLLNVEEKPFKRVTKRLSTLHSLTLSRARQAHTPPPEGNGATAGTTEQEVQTPTAAGDSATSDLAQLKEDIILDFAAFDSSIARLQFLLTANERERERYVAERERILNTAQAVRNNTVQLRVQLEQARATLEQRKKFDELADKITNNPALRTRAEQAANLRKLEEEIAELKTESETYGITWHERRDQFAKIMDESMRLRRLIRDEKEEVERREGMGDDEGGAGDTEADAGQTPRPGISSGNATPRPDSGLPAKSGAESGDAAGTPHPVSTLGARTPARDTPAPGDENQSFLKPPHDVSGGYSQATSQEASREGSMDRGDGNEAAQGTDVEMTEVKDDEEEVEEPDSPLSPLPDQTPPRPRITVDGPNADEDTMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MW25</accession>
    <name>A0AAE0MW25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H65DRAFT_9720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685744.1">
        <property type="nucleotide sequence ID" value="XM_062831628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MW25"/>
    <dbReference type="GeneID" id="87868782"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="383"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="528"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3354366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="575" mass="63120" checksum="BF940AB230F70B28" modified="2024-05-29" version="1">MEASSPLAAIRPAPPSFSQPEVLGPRNSNLAPPTGLFNFKRSNADLFNTKHAERSSPKGSLAAGSSENFKLNEAGLAFSPRARTTDSIVDSVDQMEICSSPLLPTPRRALFTSTGIENTAEGRGYATTPPPPASSSPAVNRLDMSPVPIRAPFLSRLAVSPSPTPVDSGDEDTLPDSPAAVRQLSQESKGIGAERRKLGLSRPPLARAKGYSTSSIPGRSNGSGSGLPPFRFGGRSLKVPISPSVSLSLSECFEESPPQERRTPVLPGSPCSNAAAARCRTHHGSVSSINSVRKRSPTNTPSNPFARQRKTFRRSLSMFESPGDIVKPKERTSLPSGLKSVVDVDEPQEPLLPHFFPSGENDSIPRISRDTLLEVLDGKYGSQYSHKIIVDCRFEYEYEGGHIDGAINYNDKELLARHLFETPMEGRTLLIFHCEYSAHRAPIMARHIRSEDRTINAEFYPKLTYPDVYILDGGYSGFFQNHRERCCPQAYIEMNAAEHVNTCEREMGRLRQTRKGFSRAQTYAFGQRERKSDKFEAVSPTAPGRKVSRDDEEDMIGASPILGNDRSHSRRMATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWJ2</accession>
    <name>A0AAE0MWJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H65DRAFT_415314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3354097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062685475.1">
        <property type="nucleotide sequence ID" value="XM_062823977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWJ2"/>
    <dbReference type="GeneID" id="87861131"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3354097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="193" mass="21766" checksum="3F3405AC692BD213" modified="2024-05-29" version="1">MRYIHSEETLEVPENVKVSIKSRIVTVEGPRGKLVKDLSHIAVNFSVIKKGIIGLEIHHGNRKNVAALRTVRTLINNLIIGVTKGFKYKMRYVYAHFPINVNVEKNAETGNFEVEIRNFIGEKIVRRVVMQPGVDVEISKAQKDELVLSGNSLEGVSQSAADIQQICRVRNKDIRKFLDGIYVSEKGNIVEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWP7</accession>
    <name>A0AAE0MWP7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H65DRAFT_450570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Neurospora tetraspora</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686434.1">
        <property type="nucleotide sequence ID" value="XM_062826014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWP7"/>
    <dbReference type="GeneID" id="87863168"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041995099" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3355056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11381" checksum="56CD365E2949F701" modified="2024-05-29" version="1">MFFSSSCLLLTCSVCVWYLVFHIQHAAIHTTRYCISPQMFSHPPDDVVFVSTSKLPDTTHATVFSAENTEIVHSQEQRSFPSRATVKRSKKQRPFGLCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MWQ8</accession>
    <name>A0AAE0MWQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_584921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3355208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062686586.1">
        <property type="nucleotide sequence ID" value="XM_062830911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MWQ8"/>
    <dbReference type="GeneID" id="87868065"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3355208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="410" mass="44642" checksum="0CEFDF4294EF3269" modified="2024-05-29" version="1">MFSSSNRHNAAEPSYADVWEDTETESCGSPLPRVMSFSRRPTSEFNRPKRGISAIARLVAAERKQFNPNSKPSLLTALLKPSTIVQPLVSPTTTKDPIIFPTNKPGTTRISRGLESLRSFQDLGTSTASNAPIPAEIQVAEAPSASSTNTREEHDLSPPSPPASLIAEPFDPQEYQYDKRYRPSIPCHQHQWHPIRESQPVYYAFPAYCPREPPSQESPFLAPSLSNSSSPQKECTHTRSDSAIAGIPLGAHHPEAEASTGAITIAGTATATLPPPILRSPTSPTSLLISWTANVDAYPDPPDPDPDQINPSSPASPSAKTAAAPASPSYCTRCVIPFTFDISYLDQDESWECCNCAAKNIKMWIGEQDGIVRVVLGRNLILTEWLVGVEEEEEGADGKGKGAMERVYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MXN8</accession>
    <name>A0AAE0MXN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_505902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000001">
        <property type="protein sequence ID" value="KAK3356121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062687498.1">
        <property type="nucleotide sequence ID" value="XM_062828026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MXN8"/>
    <dbReference type="GeneID" id="87865180"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3356121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="200" mass="21156" checksum="EE714A8C0A054249" modified="2024-05-29" version="1">MCRKLWPVYSCGHEQLPAQNTRTESCGNNCPEYSRGSGYYELPTDCGNVRCSTAIRRMFDKGQVKIADWKWNYGAHAGSSYGGGSSSGMGYDAGGGSDAGYGGYGGFAPIPSGPSMSCPVHGGYNSAGVPLMPPFLQPYPNAGGGGGYYQGYNNPMLRPMSAPPAPFFGQPFFPPFPAFGGGGRGCPPPPPPRIVVRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0IZM3</accession>
    <name>A0AAE0IZM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H65DRAFT_437485</name>
        <name evidence="11" type="ORF">B0H65DRAFT_507305</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000016">
        <property type="protein sequence ID" value="KAK3334253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAUEPP010000002">
        <property type="protein sequence ID" value="KAK3351987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676419.1">
        <property type="nucleotide sequence ID" value="XM_062825315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0IZM3"/>
    <dbReference type="GeneID" id="87862469"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3334253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3351987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="123" mass="14036" checksum="3292E3BF721960B0" modified="2024-05-29" version="1">MSAPSLAQAVAKRGWLSKMLKPVSNWYINAAGYRQMGLRTDDLISEEDENVLAALNRLPPKEAYDRIYRIRRATQLSLTHKLLPKNEWTTQEEDVPYLRPLIEQIEAEAAEKAALDTLTIVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J083</accession>
    <name>A0AAE0J083_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H65DRAFT_481955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="JAUEPP010000015">
        <property type="protein sequence ID" value="KAK3334260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676426.1">
        <property type="nucleotide sequence ID" value="XM_062827652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J083"/>
    <dbReference type="GeneID" id="87864806"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="218"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3334260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="463" mass="52665" checksum="7505CBB1C92A5051" modified="2024-05-29" version="1">MASDHHGAAVELKDNTVIVVLGASGDLAKKKTYPALFGLDIRIVGYARTKMDHDEYIRRIKSYIKTPTKESEQQLEEFCSICTYVSGHVFTIVSQHLKRCCYPSRGVARVIVEKPFGKDLASSRELQKSLEPDWREEELFRIDHYLGKEMVEHSYSAFRQLLPGRYLEQASHRQRPRLHSRNLSAPRVVVVTSTSSASSAMSCRTICCRFLRCLPWSAPSLSPAEDIRDEKVRVLRAIPAIEPKNVIIGQYGRSLDGSKPAYKEDDTVPKDSRCPTFCALVAYIKNERWDGVPFIMKAGKALNEQKTEIRVQFKDVTSGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLILDCLKGDHSNFVRDDELDASWRIFTPLLHYLDDNKEIIPMEYPYGSRGPAVLDDFTASYGYKFSDAAGYQWPTTSAMGSGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0D5</accession>
    <name>A0AAE0J0D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_481302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676824.1">
        <property type="nucleotide sequence ID" value="XM_062827626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0D5"/>
    <dbReference type="GeneID" id="87864780"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="85" mass="9491" checksum="52AC656781C10DBD" modified="2024-05-29" version="1" fragment="single">MLRCGKRCRNAGVSRSVFILSLTPSAAKAMSRASTLKVNSKLGFDILVIWEHTRRGRKVVELAVLFWVITTKFQAAGGILNRRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0P4</accession>
    <name>A0AAE0J0P4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_566504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000011">
        <property type="protein sequence ID" value="KAK3334390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676556.1">
        <property type="nucleotide sequence ID" value="XM_062830327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0P4"/>
    <dbReference type="GeneID" id="87867481"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3334390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="200" mass="22556" checksum="500595A91FC9B023" modified="2024-05-29" version="1">MTNAHSIPLPQESESCNKTLDAIITAPVLSIRAMLFSLYAEGDRDLKSRIEKLASDFTNLPACEDPDAPRIAAGTEGTTTSEEHSDKERATEHLPKDQQKGKETEVVPDLKVCDHCFDDFDANGYHEQDECCYHDGKMVIEHQSNIWELELGVNPMNFTAMVGYDTAYYRAHYPDAFYWDCCGQVGSNEGCIYDVHRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0W1</accession>
    <name>A0AAE0J0W1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H65DRAFT_392256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUEPP010000010">
        <property type="protein sequence ID" value="KAK3334620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062676786.1">
        <property type="nucleotide sequence ID" value="XM_062823752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0W1"/>
    <dbReference type="GeneID" id="87860906"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3334620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="75" mass="8555" checksum="90BB417CB311B23C" modified="2024-05-29" version="1" fragment="single">MDHNDPLGLGFPDEDNWVYSGPAAANSYATESVEVCTLYSIQSRKANMSYFFDEAIGIQDPSDIKRHIKRHIKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J0X7</accession>
    <name>A0AAE0J0X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H65DRAFT_336993</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Neurospora tetraspora</name>
        <dbReference type="NCBI Taxonomy" id="94610"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Sordariaceae</taxon>
            <taxon>Neurospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 560.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUEPP010000009">
        <property type="protein sequence ID" value="KAK3334901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062677067.1">
        <property type="nucleotide sequence ID" value="XM_062823581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0J0X7"/>
    <dbReference type="GeneID" id="87860735"/>
    <dbReference type="Proteomes" id="UP001278500">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="296"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="600"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3334901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001278500"/>
        </source>
    </evidence>
    <sequence length="698" mass="79528" checksum="EA84C4C21DFDC7E6" modified="2024-05-29" version="1">MSSYITNFFPSGGKQDGTRPQTPMKAGTSSFVNPVSTPQGSPSKRTLPPGANELPAAFESMKLSTPTKLATSSKLGTASKLGTPSALDSPIKLGRPQSVATPLSPGKSNLKDVDDDTFEDLTGNGSVVSVIHKQVDKNLPKPYPVPTPRRKEREQNQENTPPVVTRDPRDPASEPTYQRSHAALSRQELYQTRERASPTVKRFNTSRGLTPEERELLNKPNVKRLVNVTQLYFLDYYFDLLTYVGQRQNRLNAFKAEFPPPPETDEETYKQMWHKYAGRERANLRKRRVRLRQGDFQILTQVGQGGYGQVFLAQKKDTKEVCALKVMSKKLLFKLDEVRHVLTERDILTTAKSDWLVRLLYSFQDDKNIYLAMEYVPGGDFRTLLNNTGVLSNRHARFYIAEMFCAVDALHQLGYIHRDLKPENFLVDSTGHVKLTDFGLAAGFLAPAKIESMRIRLEKASETSVPFGKPMDQRTVAERREGYRTMRDRDTNYAKSIVGSPDYMAPEVLRGEEYDYTVDYWSLGCMLFEALTGFPPFAGSTADETWRNLKHWKEVLKRPVWEDPNYFLSNRTWSFITTCINSRSRRFNNIKDIFAHHYFAEVDWAILRETKAPFVPELDSETDAGYFDDFSNEADMAKYKEVHEKQQALEGLAERGEEMNKSLFVGFTFRHRKPATDDGASPRKPIPFEESNTFGTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0J150</accession>
    <name>A0AAE0J150_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H65DRAFT_5346
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